Search of human proteins with 157266337

Search of human proteins with 157266337

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|157266337 betaine-homocysteine methyltransferase [Homo
sapiens]
         (406 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|157266337 betaine-homocysteine methyltransferase [Homo sapiens]    832   0.0  
gi|13162290 betaine-homocysteine methyltransferase 2 [Homo sapiens]   584   e-167
gi|169790923 5-methyltetrahydrofolate-homocysteine methyltransfe...    56   7e-08
gi|24497462 Shaw-related voltage-gated potassium channel protein...    32   1.0  
gi|31652264 RNA binding motif protein 26 [Homo sapiens]                30   5.1  
gi|4757900 calreticulin precursor [Homo sapiens]                       29   8.7  
gi|4557255 adenylate cyclase 7 [Homo sapiens]                          29   8.7  
gi|24308113 KIF1 binding protein [Homo sapiens]                        29   8.7  

>gi|157266337 betaine-homocysteine methyltransferase [Homo sapiens]
          Length = 406

 Score =  832 bits (2149), Expect = 0.0
 Identities = 406/406 (100%), Positives = 406/406 (100%)

Query: 1   MPPVGGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLH 60
           MPPVGGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLH
Sbjct: 1   MPPVGGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLH 60

Query: 61  REFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIARQVADEGDALVAG 120
           REFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIARQVADEGDALVAG
Sbjct: 61  REFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIARQVADEGDALVAG 120

Query: 121 GVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKP 180
           GVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKP
Sbjct: 121 GVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKP 180

Query: 181 VAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARL 240
           VAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARL
Sbjct: 181 VAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARL 240

Query: 241 KAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCC 300
           KAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCC
Sbjct: 241 KAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCC 300

Query: 301 GFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASG 360
           GFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASG
Sbjct: 301 GFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASG 360

Query: 361 RPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFEKQKFKSQ 406
           RPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFEKQKFKSQ
Sbjct: 361 RPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFEKQKFKSQ 406


>gi|13162290 betaine-homocysteine methyltransferase 2 [Homo sapiens]
          Length = 363

 Score =  584 bits (1506), Expect = e-167
 Identities = 282/371 (76%), Positives = 312/371 (84%), Gaps = 9/371 (2%)

Query: 1   MPPVGGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLH 60
           M P G   AKKGILERL +GE+VIGDG F+  LEKRGYVKAG WTPEA +EHP+AVRQLH
Sbjct: 1   MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVIEHPDAVRQLH 60

Query: 61  REFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIARQVADEGDALVAG 120
            EFLRAGSNVMQTFTF ASED +E++          ++VN AACD+AR+VA +GDALVAG
Sbjct: 61  MEFLRAGSNVMQTFTFSASEDNMESKW---------EDVNAAACDLAREVAGKGDALVAG 111

Query: 121 GVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKP 180
           G+ QT  Y   K E  +KK+F QQLEVF  KNVDFLIAEYFEHVEEAVWAVE L  S +P
Sbjct: 112 GICQTSIYKYQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRP 171

Query: 181 VAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARL 240
           VA TMCIGPEGD+H + PGECAVRLVKAGASI+GVNC F P  SLKT++LMKEGLE A L
Sbjct: 172 VAVTMCIGPEGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGL 231

Query: 241 KAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCC 300
           KAHLM QPL +H PDC K+GF+DLPE+PFGLE RVATRWDIQKYAREAYNLGVRYIGGCC
Sbjct: 232 KAHLMVQPLGFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCC 291

Query: 301 GFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASG 360
           GFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPW+RARAR+EYWENL  ASG
Sbjct: 292 GFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASG 351

Query: 361 RPYNPSMSKPD 371
           RP+ PS+SKPD
Sbjct: 352 RPFCPSLSKPD 362


>gi|169790923 5-methyltetrahydrofolate-homocysteine
           methyltransferase [Homo sapiens]
          Length = 1265

 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 70/306 (22%), Positives = 132/306 (43%), Gaps = 48/306 (15%)

Query: 49  AVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIAR 108
           ++  P+ + Q+H+E+L AG+++++T TF ++      + +Y LE ++   +N  +  +AR
Sbjct: 71  SITQPDVIYQIHKEYLLAGADIIETNTFSSTSIA---QADYGLEHLA-YRMNMCSAGVAR 126

Query: 109 QVADEG------DALVAGGVSQTPSYLSCKSET-----------EVKKVFLQQLEVFMKK 151
           + A+E          VAG +  T   LS                E+ + + +Q +  +  
Sbjct: 127 KAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDG 186

Query: 152 NVDFLIAEYF---EHVEEAVWAVETLIA---SGKPV-AATMCIGPEGDLHGVPPGECAVR 204
            VD L+ E      + + A++A++ L     + +P+  +   +   G       GE  V 
Sbjct: 187 GVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVI 246

Query: 205 LVKAGASI-IGVNCHFDPTISLKTVKLMKEGLEAARLKAHLMSQPLAYHTPDCNKQGFID 263
            V  G  + IG+NC          ++++          A+++  P A   P+     F D
Sbjct: 247 SVSHGEPLCIGLNCALGAAEMRPFIEII-----GKCTTAYVLCYPNA-GLPNT----FGD 296

Query: 264 LPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPP 323
             E P  +         ++ +A +     V  +GGCCG  P HIR IAE +   +  +PP
Sbjct: 297 YDETPSMMAKH------LKDFAMDGL---VNIVGGCCGSTPDHIREIAEAVKNCKPRVPP 347

Query: 324 ASEKHG 329
           A+   G
Sbjct: 348 ATAFEG 353


>gi|24497462 Shaw-related voltage-gated potassium channel protein 4
           isoform a [Homo sapiens]
          Length = 635

 Score = 32.0 bits (71), Expect = 1.0
 Identities = 30/100 (30%), Positives = 43/100 (43%), Gaps = 9/100 (9%)

Query: 10  KKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLR---- 65
           ++G++ER  A     GD   V + E+     AG   P A+   PE  R L R   R    
Sbjct: 529 EEGMIERKRADSKQNGDANAVLSDEEG----AGLTQPLASSPTPEERRALRRSTTRDRNK 584

Query: 66  -AGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAAC 104
            A +  + +   YA  D    +G +VL  +  Q   EAAC
Sbjct: 585 KAAACFLLSTGDYACADGSVRKGTFVLRDLPLQHSPEAAC 624


>gi|31652264 RNA binding motif protein 26 [Homo sapiens]
          Length = 980

 Score = 29.6 bits (65), Expect = 5.1
 Identities = 12/33 (36%), Positives = 21/33 (63%)

Query: 132 KSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHV 164
           KSE E+K + + QL+VF++K     + + F+ V
Sbjct: 44  KSEKELKALCIDQLDVFLQKETQIFVEKLFDAV 76


>gi|4757900 calreticulin precursor [Homo sapiens]
          Length = 417

 Score = 28.9 bits (63), Expect = 8.7
 Identities = 18/55 (32%), Positives = 28/55 (50%), Gaps = 2/55 (3%)

Query: 352 WENLRIASGRPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFEKQKFKSQ 406
           ++N  I +   Y       + WGVTK   + M+ K+   EQ+LKE  E +K K +
Sbjct: 327 FDNFLITNDEAYAEEFGN-ETWGVTKAAEKQMKDKQ-DEEQRLKEEEEDKKRKEE 379


>gi|4557255 adenylate cyclase 7 [Homo sapiens]
          Length = 1080

 Score = 28.9 bits (63), Expect = 8.7
 Identities = 23/69 (33%), Positives = 29/69 (42%), Gaps = 2/69 (2%)

Query: 234 GLEAARLKAHLMSQPLAYHTPDCNKQGFIDLPEF-PFGLEPRVATRWDIQKYAREAYNLG 292
           GL AA  K   + +PL Y+T  C   GFI    F    LEP+V             +NL 
Sbjct: 704 GLLAASSKTRALCEPLPYYTCSC-VLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLS 762

Query: 293 VRYIGGCCG 301
             +   CCG
Sbjct: 763 PCWQWDCCG 771


>gi|24308113 KIF1 binding protein [Homo sapiens]
          Length = 621

 Score = 28.9 bits (63), Expect = 8.7
 Identities = 43/165 (26%), Positives = 66/165 (40%), Gaps = 27/165 (16%)

Query: 17  LNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTF 76
           L+A  ++ G  G + A E          TPEA  E PE   Q   E  R       T   
Sbjct: 273 LSAANVIFGQTGKISATED---------TPEAEGEVPELYHQRKGEIARCWIKYCLTLMQ 323

Query: 77  YASEDKLENRGNYVLEK------ISGQEVNEAACDIARQVADEG-----DALVAGGVSQT 125
            A     +N G   L+K      +  +E++E    I ++    G     DA+ A  V + 
Sbjct: 324 NAQLSMQDNIGELDLDKQSELRALRKKELDEEE-SIRKKAVQFGTGELCDAISA--VEEK 380

Query: 126 PSYLSCKSETEVKKVF-LQQLEVFMKK---NVDFLIAEYFEHVEE 166
            SYL      E +++F L Q  VF  K    +D  + ++ E V++
Sbjct: 381 VSYLRPLDFEEARELFLLGQHYVFEAKEFFQIDGYVTDHIEVVQD 425


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,265,316
Number of Sequences: 37866
Number of extensions: 733446
Number of successful extensions: 1881
Number of sequences better than 10.0: 8
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1874
Number of HSP's gapped (non-prelim): 10
length of query: 406
length of database: 18,247,518
effective HSP length: 105
effective length of query: 301
effective length of database: 14,271,588
effective search space: 4295747988
effective search space used: 4295747988
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.