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Search of human proteins with 156616301
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156616301 kelch-like 32 [Homo sapiens]
(620 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156616301 kelch-like 32 [Homo sapiens] 1268 0.0
gi|24308181 kelch-like 9 [Homo sapiens] 345 9e-95
gi|45643138 kelch-like 13 [Homo sapiens] 343 3e-94
gi|31542246 kelch-like 36 [Homo sapiens] 326 3e-89
gi|8922854 kelch-like 26 [Homo sapiens] 291 2e-78
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 274 2e-73
gi|24432026 kelch-like [Homo sapiens] 249 7e-66
gi|40807500 kelch-like 20 [Homo sapiens] 241 1e-63
gi|226442729 kelch-like 15 [Homo sapiens] 241 1e-63
gi|23397572 kelch-like 34 [Homo sapiens] 238 9e-63
gi|55741643 kelch-like 14 [Homo sapiens] 223 5e-58
gi|38194229 kelch-like 17 [Homo sapiens] 218 1e-56
gi|14780904 kelch-like 1 protein [Homo sapiens] 213 3e-55
gi|166235129 kelch-like 3 [Homo sapiens] 210 4e-54
gi|55925604 kelch-like 18 [Homo sapiens] 204 3e-52
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 203 4e-52
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 203 4e-52
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 202 6e-52
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 201 1e-51
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 201 1e-51
gi|11056006 kelch-like 12 [Homo sapiens] 201 2e-51
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 198 1e-50
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 195 9e-50
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 187 3e-47
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 187 3e-47
gi|109150407 kelch-like 6 [Homo sapiens] 186 7e-47
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 185 1e-46
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 178 2e-44
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 175 1e-43
gi|40018614 DRE1 protein [Homo sapiens] 174 2e-43
>gi|156616301 kelch-like 32 [Homo sapiens]
Length = 620
Score = 1268 bits (3281), Expect = 0.0
Identities = 620/620 (100%), Positives = 620/620 (100%)
Query: 1 MPSERCLSIQEMLTGQRLCHSESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVL 60
MPSERCLSIQEMLTGQRLCHSESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVL
Sbjct: 1 MPSERCLSIQEMLTGQRLCHSESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVL 60
Query: 61 AACSDYFRAMFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGS 120
AACSDYFRAMFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGS
Sbjct: 61 AACSDYFRAMFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGS 120
Query: 121 HLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPE 180
HLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPE
Sbjct: 121 HLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPE 180
Query: 181 EVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMDELLQYIRFGLMDVDT 240
EVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMDELLQYIRFGLMDVDT
Sbjct: 181 EVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMDELLQYIRFGLMDVDT 240
Query: 241 LHTVALSHPLVQASETATALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKRE 300
LHTVALSHPLVQASETATALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKRE
Sbjct: 241 LHTVALSHPLVQASETATALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKRE 300
Query: 301 VCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASG 360
VCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASG
Sbjct: 301 VCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASG 360
Query: 361 RTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYC 420
RTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYC
Sbjct: 361 RTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYC 420
Query: 421 PKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPM 480
PKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPM
Sbjct: 421 PKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPM 480
Query: 481 LQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNES 540
LQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNES
Sbjct: 481 LQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNES 540
Query: 541 GVAVHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAP 600
GVAVHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAP
Sbjct: 541 GVAVHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAP 600
Query: 601 YFTCPNLQTLQVPHHRIGTI 620
YFTCPNLQTLQVPHHRIGTI
Sbjct: 601 YFTCPNLQTLQVPHHRIGTI 620
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 345 bits (884), Expect = 9e-95
Identities = 217/586 (37%), Positives = 326/586 (55%), Gaps = 23/586 (3%)
Query: 17 RLCHSESHNDSVLAALNQQRSDGILCDITLIAEE--QKFHAHKAVLAACSDYFRAMFSLC 74
R S +H+ VL +Q R +G+LCD+TL+ + + F H+A++A+ SDYF+AMF+
Sbjct: 25 RFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGG 84
Query: 75 MVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHY 134
M E + LHGV +GLK+ ++F YT ++ L +QD L A S LQ+L +L+ C +
Sbjct: 85 MKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVF 144
Query: 135 LIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVL 194
LI ++ N +++ R+A+ +NL ++K V +F++K+ LL + E L LP+ L VL
Sbjct: 145 LISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLST--GEFLKLPFERLAFVL 202
Query: 195 KSDRLTSLSEEQIWQLAVRWLE-HNCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQA 253
S+ L +E ++++ A RWL + Y +L++ IRF LM L + ++
Sbjct: 203 SSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRT 262
Query: 254 SETATALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKV-KELRYFNP 312
T L+ EA Y Y QPV Q+ RT R S L +GG R+ V KELR ++
Sbjct: 263 DNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDE 322
Query: 313 VDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYD 372
QE W LAPM R H +AV+G+FL+V GG+ + + AV T R+D
Sbjct: 323 RAQE---------WRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFD 373
Query: 373 PRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSF 432
PR N W ++A + R F L A++ +LYAVGGR+ + L TVE Y P+ N+W++V
Sbjct: 374 PRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGE-LATVECYNPRMNEWSYVAKM 432
Query: 433 DRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAV 492
HAG V GL++ISGG+T+ +QN LM ++P+ +KW+ ++PM R H M V
Sbjct: 433 SEPHYGHAGTVYGGLMYISGGITHDT-FQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTV 491
Query: 493 QRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLV 552
KLYV+GGN +D V + Y+ DQWT +L GQ++ GVAV +IY+V
Sbjct: 492 GDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPI-AAMLRGQSDVGVAVFENKIYVV 550
Query: 553 GGYSIWTNEPLA-CIQVLDVSREGKEEVFYGPTLPFASNGIAACFL 597
GGYS W N + +Q D ++ +VF LP + GI AC L
Sbjct: 551 GGYS-WNNRCMVEIVQKYDPEKDEWHKVF---DLPESLGGIRACTL 592
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 343 bits (880), Expect = 3e-94
Identities = 214/586 (36%), Positives = 322/586 (54%), Gaps = 23/586 (3%)
Query: 17 RLCHSESHNDSVLAALNQQRSDGILCDITLIA--EEQKFHAHKAVLAACSDYFRAMFSLC 74
R+ S +H+ VL +Q R +G+LCD+TL+ + F H+ ++A+ SDYF+AMF+
Sbjct: 67 RIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGG 126
Query: 75 MVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHY 134
M E + LHGV+ +GL++ ++F YT ++ L +QD L A S LQ+L +L+ C +
Sbjct: 127 MKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVF 186
Query: 135 LIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVL 194
LI + N +++ R+A+ +NLT ++K V F++K+ LL + E L LP+ L VL
Sbjct: 187 LISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLST--GEFLKLPFERLAFVL 244
Query: 195 KSDRLTSLSEEQIWQLAVRWLE-HNCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQA 253
S+ L +E ++++ RWL + +L++ IRF LM L + ++
Sbjct: 245 SSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRT 304
Query: 254 SETATALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKV-KELRYFNP 312
T L+ EA Y Y QPV Q+ RT R + L +GG R+ V KELR ++
Sbjct: 305 DNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDE 364
Query: 313 VDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYD 372
E W LAPM R H +AV+G+FL+V GG+ + + AV T R+D
Sbjct: 365 KAHE---------WKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFD 415
Query: 373 PRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSF 432
PR N W ++A + R F L A++ YLYAVGGRN + LPTVE Y P+ N+WT+V
Sbjct: 416 PRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGE-LPTVECYNPRTNEWTYVAKM 474
Query: 433 DRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAV 492
HAG V G+++ISGG+T+ +Q LM ++P+ +KWI ++PM R H M V
Sbjct: 475 SEPHYGHAGTVYGGVMYISGGITHDT-FQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTV 533
Query: 493 QRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLV 552
+LYV+GGN +D V + Y+ DQWT +L GQ++ GVAV +IY+V
Sbjct: 534 GERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPI-AAMLRGQSDVGVAVFENKIYVV 592
Query: 553 GGYSIWTNEPLA-CIQVLDVSREGKEEVFYGPTLPFASNGIAACFL 597
GGYS W N + +Q D ++ +VF LP + GI AC L
Sbjct: 593 GGYS-WNNRCMVEIVQKYDPDKDEWHKVF---DLPESLGGIRACTL 634
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 326 bits (836), Expect = 3e-89
Identities = 205/578 (35%), Positives = 308/578 (53%), Gaps = 20/578 (3%)
Query: 24 HNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADEV 83
H+ +VL LN+QR G+ CD+ L+A+EQ+ AH+ +LA CSDYF +MF++ M E+ EV
Sbjct: 28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEV 87
Query: 84 NLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFN 143
L G + +GLK ++F Y G+++L+ G I VL LQ+ +++ C YL QE++ N
Sbjct: 88 ELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Query: 144 YLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLS 203
YL L LA +++L L+ + F++ H L P+ + + L L S +
Sbjct: 148 YLYLQELASIYSLKRLDAFIDGFILNHFG-TLSFTPDFLQNVSMQKLCVYLSSSEVQREC 206
Query: 204 EEQIWQLAVRWLEHNCHYQ-YMDELLQYIRFGLMDV-DTLHTVALS-HPLVQASETATAL 260
E + Q A++WL + + ++L+ I F L+ D LH V + L+
Sbjct: 207 EHDLLQAALQWLTQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGF 266
Query: 261 VNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENALI 320
+ EA+ YH ++ AQPV QT+RT R + L +GG+ E C D L
Sbjct: 267 IEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERC-------LELSDDTCYLD 319
Query: 321 AAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAE 380
A W + P+P RSHHCVAV+G F+F+AGG +G A RYDPR W +
Sbjct: 320 AKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIK 379
Query: 381 IAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHA 440
+A M R F L ++E+ L A+GGRNE L +VE Y PK + W++V R HA
Sbjct: 380 VASMNQRRVDFYLASIEDMLVAIGGRNE-NGALSSVETYSPKTDSWSYVAGLPRFTYGHA 438
Query: 441 GYVADGLLWISGGVT-NTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVL 499
G + ++ISGG Y+ L+ Y+ + W R PM R +HSM ++ +Y +
Sbjct: 439 GTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSI 498
Query: 500 GGNDLDYNN-DRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYSIW 558
GG+D + + +R V +++Y+ +QWTR LL +ESGVAV GRIY++GGYS W
Sbjct: 499 GGSDDNIESMERFDVLGVEAYSPQCNQWTRV-APLLHANSESGVAVWEGRIYILGGYS-W 556
Query: 559 TNEPLA-CIQVLDVSREGKEEVFYGPTLPFASNGIAAC 595
N + +QV D RE ++ G LP A G +AC
Sbjct: 557 ENTAFSKTVQVYD--REA-DKWSRGVDLPKAIAGGSAC 591
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 291 bits (744), Expect = 2e-78
Identities = 192/578 (33%), Positives = 298/578 (51%), Gaps = 14/578 (2%)
Query: 23 SHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADE 82
SH+ S+L L R+ G L D+ L + F AHK VLAACSDYFRAMF+ M E+ D
Sbjct: 44 SHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDV 103
Query: 83 VNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSF 142
+ L GV++ GL+ ++FAY+ ++ L+ +QDVL A LQ+L ++ LC +L ++
Sbjct: 104 IELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVE 163
Query: 143 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSL 202
L++ ++A F+L L ++V F +H ++ + E+ L LP L L+S+RL S
Sbjct: 164 TCLNIGQMATTFSLASLRESVDAFTFRHFLQI--AEEEDFLRLPLERLVFFLQSNRLQSC 221
Query: 203 SEEQIWQLAVRWLEHN-CHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALV 261
+E +++ AVRWL+H+ +L +IRF LM L + ++ +
Sbjct: 222 AEIDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYL 281
Query: 262 NEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENALIA 321
EA Y + Q Q+ RT R +L GG + + A
Sbjct: 282 LEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGA--- 338
Query: 322 AIANWSELAPMPVGRSHHCVAVMGDFLFVAGGE-VEHASGRTCAVRTACRYDPRSNSWAE 380
++ EL M VG SH CVAV+ +F++VAGG+ +++ SG AV RYDP N W
Sbjct: 339 --RHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEG-AVDACYRYDPHLNRWLR 395
Query: 381 IAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHA 440
+ M+ R F L + +YA GGRN L +VERYCP++N+W + S R HA
Sbjct: 396 LQAMQESRIQFQLNVLCGMVYATGGRNRAGS-LASVERYCPRRNEWGYACSLKRRTWGHA 454
Query: 441 GYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLG 500
G + G L+ISGG + + + L Y+P ++W ++PM + RV H+M ++Y LG
Sbjct: 455 GAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALG 514
Query: 501 GNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYSIWTN 560
G +D+ + V ++ Y +TDQWT + + GQ+E+G + +IY+VGGY+ N
Sbjct: 515 GR-MDHVDRCFDVLAVEYYVPETDQWTSVS-PMRAGQSEAGCCLLERKIYIVGGYNWRLN 572
Query: 561 EPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLP 598
+QV + + E + P FA A LP
Sbjct: 573 NVTGIVQVYNTDTDEWERDLHFPE-SFAGIACAPVLLP 609
>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
sapiens]
Length = 634
Score = 274 bits (700), Expect = 2e-73
Identities = 178/583 (30%), Positives = 294/583 (50%), Gaps = 26/583 (4%)
Query: 23 SHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADE 82
S+ ++L L++ R + LCD+ + + + F HK+V+A+CS+YF +++ +
Sbjct: 54 SYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYF---YNILKKDPSIQR 110
Query: 83 VNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSF 142
V+L+ ++ LGL + +AYTG++ L I +++A +LQ+ L+ +CS +LI+E++
Sbjct: 111 VDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVE 170
Query: 143 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSL 202
N + + +A+ ++L + A F+ + E +S ++ + L + + E+L D L
Sbjct: 171 NCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAES--DQFMKLTFEQINELLIDDDLQLP 228
Query: 203 SEEQIWQLAVRWLEHN-CHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALV 261
SE +Q+A++WLE + +Y +LL IRFG + L S P + L+
Sbjct: 229 SEIVAFQIAMKWLEFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLL 288
Query: 262 NEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKK--REVCKVKELRYFNPVDQENAL 319
+A+ YH Y Q Q+RRT+ R L +GG+ E +++ Y +P EN
Sbjct: 289 VDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDP---EN-- 343
Query: 320 IAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTC--AVRTACRYDPRSNS 377
WS+L MP + CVAVM FL+VAGGE ++ + AV CRYDPR N+
Sbjct: 344 -----GWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNT 398
Query: 378 WAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLS 437
W +A M R HF L +YA GGRN L ++E Y P N+W + +
Sbjct: 399 WIHLASMNQKRTHFSLSVFNGLVYAAGGRN-AEGSLASLECYVPSTNQWQPKTPLEVARC 457
Query: 438 CHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLY 497
CHA VADG + ++GG A Y + Y+P + W + R +H + ++Y
Sbjct: 458 CHASAVADGRVLVTGGYIANA-YSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVY 516
Query: 498 VLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYSI 557
V+GG+ L +R+ V ++ Y+ T QW+ L G + +GV+ +GR YLVGG++
Sbjct: 517 VMGGSQLGPRGERVDVLTVECYSPATGQWSYA-APLQVGVSTAGVSALHGRAYLVGGWNE 575
Query: 558 WTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAP 600
+ CIQ E LP A+ G++ C L P
Sbjct: 576 GEKKYKKCIQCFSPELNEWTE---DDELPEATVGVSCCTLSMP 615
>gi|24432026 kelch-like [Homo sapiens]
Length = 634
Score = 249 bits (635), Expect = 7e-66
Identities = 180/597 (30%), Positives = 288/597 (48%), Gaps = 48/597 (8%)
Query: 21 SESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGA 80
S H+ ++L L R GIL D+ L+ E + AH+ +LAA DYFR MF+ + E
Sbjct: 29 SAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQ 88
Query: 81 DEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELN 140
+EV +HGV+ + Q L F YT ++ L +Q+ L A LQ+ E+++ C +L+ ++
Sbjct: 89 EEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVD 148
Query: 141 SFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLT 200
N LD+YRLA+LF+L+ L + + +++K+ + SR ++ LP + +L S+RL
Sbjct: 149 EENILDVYRLAELFDLSRLTEQLDTYILKNF--VAFSRTDKYRQLPLEKVYSLLSSNRLE 206
Query: 201 SLSEEQIWQLAVRWLEHNCHYQYMD------------ELLQYIRFGLMDVDTLHTVALSH 248
E ++++ A+ + HY +LL+ +RF LM+ + L + H
Sbjct: 207 VSCETEVYEGALLY-----HYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRL---H 258
Query: 249 PLVQASETATALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKV--KE 306
+ S V AL YH++ QP Q+ +T+ R + GG V +
Sbjct: 259 DKLDPSPLRDT-VASALMYHRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQ 317
Query: 307 LRYFNPVDQENALIAAIANWSEL-APMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAV 365
+Y NP+ + W A + S+ +AV+ +F+++ GG+ R A
Sbjct: 318 AKYLNPL---------LGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFR--AE 366
Query: 366 RTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNK 425
RYDPR N W +I ++ + + Y+YAV GR + L VERY P N
Sbjct: 367 SRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGR-DYHNDLNAVERYDPATNS 425
Query: 426 WTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRV 485
W +V R + HAG +G ++I+ G Y Y+P N W + + RR
Sbjct: 426 WAYVAPLKREVYAHAGATLEGKMYITCG-RRGEDYLKETHCYDPGSNTWHTLADGPVRRA 484
Query: 486 YHSMAAVQRKLYVLGG--NDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVA 543
+H MA + KLYV+GG ND Y D V + Y+ + QW+ L G E G+A
Sbjct: 485 WHGMATLLNKLYVIGGSNNDAGYRRD---VHQVACYSCTSGQWSSV-CPLPAGHGEPGIA 540
Query: 544 VHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAP 600
V + RIY++GG S + + DV ++ EE GP L + +G+AAC L P
Sbjct: 541 VLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEE---GPQLDNSISGLAACVLTLP 594
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 241 bits (616), Expect = 1e-63
Identities = 171/559 (30%), Positives = 277/559 (49%), Gaps = 39/559 (6%)
Query: 21 SESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGA 80
S+ H L +N R LCD+ L+ +K +AH+ +L+ACS YFRAMF+ + ES
Sbjct: 47 SDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQ 106
Query: 81 DEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELN 140
EV + + ++ ++FAYT QI +E G +Q +L A LQL E+ C +L ++L+
Sbjct: 107 TEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLD 166
Query: 141 SFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLT 200
N L + AD + L + F + E+++S EE + LP L +++ SD L
Sbjct: 167 PSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMES--EEFMLLPANQLIDIISSDELN 224
Query: 201 SLSEEQIWQLAVRWLEHNCHYQ--YMDELLQYIRFGLMDVDTLHTVALSHPLVQASETAT 258
SEEQ++ + W++++ + + ++LQ++R L+ L S PL+++ E
Sbjct: 225 VRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECR 284
Query: 259 ALVNEALEYHQSIYAQPVWQTRRTKPRFQ---SDTLYIIGGKKREVCK---VKELRYFNP 312
LV+EA Y +P+ Q RT+PR + L+ +GG C + + ++P
Sbjct: 285 DLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGG----WCSGDAISSVERYDP 340
Query: 313 VDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYD 372
E W +A M R V+V+ D L+ GG + + + RYD
Sbjct: 341 QTNE---------WRMVASMSKRRCGVGVSVLDDLLYAVGGH-----DGSSYLNSVERYD 386
Query: 373 PRSNSW-AEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQS 431
P++N W +++AP CR + + +LYAVGG++ + L VERY PK+NKWT V S
Sbjct: 387 PKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGV-SCLNIVERYDPKENKWTRVAS 445
Query: 432 FDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAA 491
A V G L+ GG T+ N + Y P +N+W + +PM RR + A
Sbjct: 446 MSTRRLGVAVAVLGGFLYAVGGSDGTSPL-NTVERYNPQENRWHTIAPMGTRRKHLGCAV 504
Query: 492 VQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYL 551
Q +Y +GG D D + + YN T+QW+ + + ++ G+AV NG++
Sbjct: 505 YQDMIYAVGGRD-----DTTELSSAERYNPRTNQWSPV-VAMTSRRSGVGLAVVNGQLMA 558
Query: 552 VGGYSIWTNEPLACIQVLD 570
VGG+ T L I+V D
Sbjct: 559 VGGFDGTTY--LKTIEVFD 575
>gi|226442729 kelch-like 15 [Homo sapiens]
Length = 604
Score = 241 bits (615), Expect = 1e-63
Identities = 169/600 (28%), Positives = 296/600 (49%), Gaps = 36/600 (6%)
Query: 21 SESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGA 80
S H+ SV A +G+L D+TL+ E+ +F AHKA+LA SDYFR MF+ M E
Sbjct: 10 SSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQ 69
Query: 81 DEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELN 140
D+++L G+T+ G L+F Y G I L + ++L A ++QL+E++ C +L+ ++
Sbjct: 70 DKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKIC 129
Query: 141 SFNYLDLYRLADLF--NLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDR 198
N ++ RL D F N+ + + + FL+ + L+ SRP+ + L + L L +D
Sbjct: 130 LENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLM-SRPDFLSYLSFEKLMSYLDNDH 188
Query: 199 LTSLSEEQIWQLAVRWLEHN-CHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETA 257
L+ E ++++ WL H+ +++ D ++Q IRF LM ++ + + S
Sbjct: 189 LSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQL 248
Query: 258 TALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQEN 317
V++AL Y Q+++ QP+ + ++ I K + + + + V+ +
Sbjct: 249 RYEVDQALNYFQNVHQQPLLDMKSSR----------IRSAKPQTTVFRGMIGHSMVNSKI 298
Query: 318 ALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNS 377
L+ W EL V C+A++ +F+F+ GGE G A RYDPR NS
Sbjct: 299 LLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNS 358
Query: 378 WAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLS 437
W ++A M R F +G + +++YAV GR + + ERY +KW FV + +
Sbjct: 359 WLQMADMSVPRSEFAVGVIGKFIYAVAGRTR-DETFYSTERYDITNDKWEFVDPYPVNKY 417
Query: 438 CHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQ---------------NKWISRSPMLQ 482
H G V + L+I+GG+T+++ ++ V++P++ N W ++S M
Sbjct: 418 GHEGTVLNNKLFITGGITSSST-SKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNY 476
Query: 483 RRVYHSMAAVQRKLYVLGG--NDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNES 540
R +H M + KLYV GG L + + + YN +TDQWT ++ G++
Sbjct: 477 ARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWT-ILASMPIGRSGH 535
Query: 541 GVAVHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAP 600
GV V + +I ++GG + + + + KE+ + P +P +G+ C L P
Sbjct: 536 GVTVLDKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEY--PRMPCKLDGLQVCNLHFP 593
>gi|23397572 kelch-like 34 [Homo sapiens]
Length = 644
Score = 238 bits (608), Expect = 9e-63
Identities = 187/629 (29%), Positives = 289/629 (45%), Gaps = 61/629 (9%)
Query: 18 LCHSESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVE 77
L + ++H ++L R++G LCD+TL E +F AH+++LA SDYFRA+F E
Sbjct: 5 LSYCKAHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQE 64
Query: 78 SGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQ 137
S A ++LH ++ GL++ L+F YT + L ++D L A S+LQ+ E L LC YL +
Sbjct: 65 SRARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLER 124
Query: 138 ELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLK--SRPEEVLTLPYCLLQEVLK 195
+L N +A F L A +V HL ELL + P +L L L+ VL
Sbjct: 125 QLAPENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLG 184
Query: 196 SDRLTSLSEEQIWQLAVRWLEHNC---HYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQ 252
+ + + E ++ LA+ WL + ELL+ +RFGL+ D L V LV
Sbjct: 185 APDVARVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPADVLRRVYSGSGLVL 244
Query: 253 ASETATALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKEL----- 307
+ L+ +AL YH + QP+ Q +T R + ++GG++ ++E+
Sbjct: 245 PAR-VKGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQR 303
Query: 308 ----RYFNPVDQE------------------NALIAAIAN--WSELAPMPVGRSHHCVAV 343
+ P +E N + + N W L +P H V
Sbjct: 304 AARGQVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCT 363
Query: 344 MGDFLFVAGGEVEHASGRT-------CAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAM 396
G+FLFV GGE S + RYDPR ++W E+ M+ R HF GA+
Sbjct: 364 AGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAV 423
Query: 397 EEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVAD-GLLWISGGVT 455
E L AVGG +VL +VE Y ++++WT + R+L HAG V D G+++ISGG
Sbjct: 424 GERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKA 483
Query: 456 NT----AQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRI 511
A L V P + W ++PM R H MA ++ ++ G ++
Sbjct: 484 GRGEGGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFS---- 539
Query: 512 LVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYSIWTNE---PLACIQV 568
I+ Y+ DQWTR L + G+AV L+GG W + P +
Sbjct: 540 ---EIERYDPGADQWTRLR-PLPYDRFCYGLAVVEETALLLGGLK-WRDSRQVPTRNVVG 594
Query: 569 LDVSREGKEEVFYGPTLPFASNGIAACFL 597
D+ + E++ G LP+A +G+ L
Sbjct: 595 YDLDLDRWEDI--GCALPWAWSGLRCAVL 621
>gi|55741643 kelch-like 14 [Homo sapiens]
Length = 628
Score = 223 bits (567), Expect = 5e-58
Identities = 145/476 (30%), Positives = 240/476 (50%), Gaps = 27/476 (5%)
Query: 85 LHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNY 144
L G +S+GL+ LE+ YT + L +++VL+ L + ++ LC +L +++ NY
Sbjct: 127 LQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNY 186
Query: 145 LDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSE 204
+ ++A L L +K +LV E+VL L + ++ +L S SE
Sbjct: 187 KQVCKIAALHGLEETKKLANKYLV-----------EDVLLLNFEEMRALLDSLPPPVESE 235
Query: 205 EQIWQLAVRWLEHN--CHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALVN 262
++Q++V WLEH+ QY +L++ +RF L+ L S ++ L+
Sbjct: 236 LALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLL 295
Query: 263 EALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKE--LRYFNPVDQENALI 320
+A+ YH + Q Q+ ++ R L ++GG ++ ++Y++ D++
Sbjct: 296 DAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYD--DEKKT-- 351
Query: 321 AAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAE 380
W L MP +HHCV + +FLFV GGE + + RYDPR NSW +
Sbjct: 352 -----WKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQ 406
Query: 381 IAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHA 440
+ PM+ R F ++++LY +GGRNE L +VE Y + N+W +V S + L+ HA
Sbjct: 407 LPPMQERRASFYACRLDKHLYVIGGRNE-TGYLSSVECYNLETNEWRYVSSLPQPLAAHA 465
Query: 441 GYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLG 500
G V +G ++ISGGV N +Y L Y+P + W + M +R H++A + +LY +G
Sbjct: 466 GAVHNGKIYISGGVHN-GEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIG 524
Query: 501 GNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYS 556
GN L + V ++ Y+ DQW +L G++ G AV + IYLVGGYS
Sbjct: 525 GNHLK-GFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYS 579
Score = 61.6 bits (148), Expect = 2e-09
Identities = 27/50 (54%), Positives = 37/50 (74%)
Query: 23 SHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFS 72
SH+D++L LN + CD+TL A+ Q+FH HKAVLA+CS YFR++FS
Sbjct: 14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Score = 43.9 bits (102), Expect = 4e-04
Identities = 28/104 (26%), Positives = 45/104 (43%), Gaps = 3/104 (2%)
Query: 326 WSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAEI-APM 384
W+ M R+ H +AVM D L+ GG + C YDP+ + W + P+
Sbjct: 498 WARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVEC-YDPKGDQWNILQTPI 556
Query: 385 KNCREHFVLGAMEEYLYAVGGRN-ELRQVLPTVERYCPKKNKWT 427
R +++ +Y VGG + + + YCP+K WT
Sbjct: 557 LEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWT 600
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 218 bits (555), Expect = 1e-56
Identities = 168/578 (29%), Positives = 269/578 (46%), Gaps = 68/578 (11%)
Query: 15 GQRLCH-SESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSL 73
G + H S+ H A+++ R G+LCDI L ++ AHK VLA+CS YF AMF+
Sbjct: 64 GHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTN 123
Query: 74 CMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSH 133
M ES V LH + L Q ++FAYT +I++ G +Q +L A S LQL + + C
Sbjct: 124 EMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCK 183
Query: 134 YLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEV 193
+L+ +L+ N L + AD + + L KA ++++H ++ K+ EE + LP + E+
Sbjct: 184 FLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKT--EEFMLLPLKQVLEL 241
Query: 194 LKSDRLTSLSEEQIWQLAVRWLEH--NCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLV 251
+ SD L SEE++++ + W++H + Q++ L++ +R L+ D L + LV
Sbjct: 242 VSSDSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLV 301
Query: 252 QASETATALVNEALEYHQSIYAQPVWQTRRTKPR---FQSDTLYIIGGKKREVCKVKELR 308
+ L+ EAL++H + V T RT+PR L+ +GG
Sbjct: 302 RHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEA 361
Query: 309 YFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGG--------------- 353
Y D+ W +A M R+ VA +G+ L+ GG
Sbjct: 362 YDTRTDR----------WHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDP 411
Query: 354 -------EVEHASGRTC--------------------AVRTACRYDPRSNSWAEIAPMKN 386
EV + R+C + +A RYDP + +W +A M
Sbjct: 412 VTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMST 471
Query: 387 CREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADG 446
R + + ++ LYAVGG + L TVE+Y P+ N W+ V S S V +G
Sbjct: 472 RRRYVRVATLDGNLYAVGGYDSSSH-LATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEG 530
Query: 447 LLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDY 506
L+++GG T+ N + Y P W S +PM RR H + A+ LY +GGND
Sbjct: 531 ALYVAGGNDGTS-CLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSS 589
Query: 507 NNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAV 544
+ + I+ YN T++W + + T ++ GVAV
Sbjct: 590 S-----LNSIEKYNPRTNKWVAASC-MFTRRSSVGVAV 621
Score = 75.5 bits (184), Expect = 1e-13
Identities = 50/168 (29%), Positives = 77/168 (45%), Gaps = 7/168 (4%)
Query: 326 WSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMK 385
W+ +A M R + VA + L+ GG + + T +Y+P+ N W+ +A M
Sbjct: 463 WTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSH-----LATVEKYEPQVNVWSPVASML 517
Query: 386 NCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVAD 445
+ R + +E LY GG N+ L +VERY PK W V + S H D
Sbjct: 518 SRRSSAGVAVLEGALYVAGG-NDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMD 576
Query: 446 GLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQ 493
G L+ GG ++ N + Y P NKW++ S M RR +A ++
Sbjct: 577 GWLYAVGGNDGSSSL-NSIEKYNPRTNKWVAASCMFTRRSSVGVAVLE 623
Score = 38.9 bits (89), Expect = 0.014
Identities = 26/89 (29%), Positives = 46/89 (51%), Gaps = 6/89 (6%)
Query: 467 YEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQW 526
Y+ ++W + M RR +AAV +LY +GG D + + ++SY+ T+ W
Sbjct: 362 YDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSD-----LATVESYDPVTNTW 416
Query: 527 TRCNFNLLTGQNESGVAVHNGRIYLVGGY 555
+ ++ T ++ GVA +G +Y GGY
Sbjct: 417 -QPEVSMGTRRSCLGVAALHGLLYSAGGY 444
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 213 bits (543), Expect = 3e-55
Identities = 165/544 (30%), Positives = 267/544 (49%), Gaps = 29/544 (5%)
Query: 16 QRLCHSESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCM 75
Q + H+E + + L QQ+ LCD+ LI +K AH+ VL++ SDYF AMF+ +
Sbjct: 190 QAVHHAEQTFRKMESYLKQQQ----LCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDV 245
Query: 76 VESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYL 135
E+ +E+ + G+ L ++FAYTG + L+ I+++LAA LQL +++ +C H+L
Sbjct: 246 CEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFL 305
Query: 136 IQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLK 195
++ L+ N L + AD L K + ++++ E++ R +E L LP L ++L
Sbjct: 306 MKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVI--RNQEFLLLPAEELHKLLA 363
Query: 196 SDRLTSLSEEQIWQLAVRWLEHNCHYQYMD--ELLQYIRFGLMDVDTLHTVALSHPLVQA 253
SD + EE I+ + W++++ + D LL +IR L+ L + +H L +
Sbjct: 364 SDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLE-NHALFKN 422
Query: 254 SETATALVNEALEYHQSIYAQPVWQTRRTKPRFQS-DTLYIIGGKKREVCKVKELRYFNP 312
L+ EA++YH + + Q+ RTKPR + TLY +GG K
Sbjct: 423 DLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNN----KGATTIEK 478
Query: 313 VDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYD 372
D L W + M R VAV+ D LFV GG G C Y+
Sbjct: 479 YDLRTNL------WIQAGMMNGRRLQFGVAVIDDKLFVIGGR----DGLKTLNTVEC-YN 527
Query: 373 PRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSF 432
P++ +W + PM R + +E +YAVGG + L TVER+ P+ +WTFV S
Sbjct: 528 PKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGW-SYLNTVERWDPQSQQWTFVASM 586
Query: 433 DRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAV 492
+ S +G L+ GG + + + + Y+P+ NKW +PM +RR +A
Sbjct: 587 SIARSTVGVAALNGKLYSVGG-RDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATC 645
Query: 493 QRKLYVLGGNDLDYNND-RILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYL 551
LY +GG+D +N L+ +++ Y+ TD WT L ++ GV + R+Y
Sbjct: 646 DGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMV-APLSMPRDAVGVCLLGDRLYA 704
Query: 552 VGGY 555
VGGY
Sbjct: 705 VGGY 708
Score = 63.9 bits (154), Expect = 4e-10
Identities = 43/144 (29%), Positives = 70/144 (48%), Gaps = 12/144 (8%)
Query: 291 LYIIGGKKREVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFV 350
LY +GG+ C + + Y++P + W+ APM R VA FL+
Sbjct: 602 LYSVGGRDGSSC-LSSMEYYDPHTNK---------WNMCAPMCKRRGGVGVATCDGFLYA 651
Query: 351 AGGEVEHASGRTCAVRTAC-RYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNEL 409
GG AS + RYDP++++W +AP+ R+ + + + LYAVGG +
Sbjct: 652 VGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDG- 710
Query: 410 RQVLPTVERYCPKKNKWTFVQSFD 433
+ L T+E Y P+ N+WT + S +
Sbjct: 711 QTYLNTMESYDPQTNEWTQMASLN 734
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 210 bits (534), Expect = 4e-54
Identities = 161/565 (28%), Positives = 265/565 (46%), Gaps = 56/565 (9%)
Query: 23 SHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADE 82
+H +N+ RS +LCD+ ++AE+ + AH+ VLAACS YF AMF+ M ES A +
Sbjct: 31 AHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKK 90
Query: 83 VNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSF 142
+ + V L + +++ YT +I + +Q +L A S LQL+++ C +L +L+
Sbjct: 91 IEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPT 150
Query: 143 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSL 202
N L + AD+ T L + + +H E++ EE L+L + ++ SD+LT
Sbjct: 151 NCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLG--EEFLSLSLDQVCSLISSDKLTVS 208
Query: 203 SEEQIWQLAVRWL--EHNCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATAL 260
SEE++++ + W+ E ++M +L++++R L+ D L L++ + T
Sbjct: 209 SEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDF 268
Query: 261 VNEALEYHQSIYAQPVW-QTRRTKPRFQ---SDTLYIIGGKKREVCKVKELRYFN----- 311
+ EA++YH Q + + RTKPR + ++GG+ + + E F
Sbjct: 269 LIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWD 328
Query: 312 -----PVDQENALIAAIA--------------------------NWSELAPMPVGRSHHC 340
P + A + +A W+ +A M RS
Sbjct: 329 QIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLG 388
Query: 341 VAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYL 400
AV+ D L+ GG G T + + Y ++N W +APM R +G +E L
Sbjct: 389 AAVLNDLLYAVGG----FDGST-GLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKL 443
Query: 401 YAVGGRN-ELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQ 459
YAVGG + RQ L TVE+Y P N+W +V S V G L+ +GG +
Sbjct: 444 YAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGG-HDGPL 502
Query: 460 YQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSY 519
+ + VY+P N W + M R + AV LYV+GG+D N + ++ Y
Sbjct: 503 VRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN-----LASVEYY 557
Query: 520 NIDTDQWTRCNFNLLTGQNESGVAV 544
N TD+WT N+ TG++ +GVAV
Sbjct: 558 NPVTDKWTLLPTNMSTGRSYAGVAV 582
Score = 50.8 bits (120), Expect = 4e-06
Identities = 42/174 (24%), Positives = 86/174 (49%), Gaps = 11/174 (6%)
Query: 395 AMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYV-ADGLLWISGG 453
++ + + VGG + + + +VE Y ++++W + S C AG V G ++ GG
Sbjct: 298 SLPKVMIVVGG--QAPKAIRSVECYDFEEDRWDQIAELP-SRRCRAGVVFMAGHVYAVGG 354
Query: 454 VTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILV 513
+ + + + VY+ +++W S + M +RR A + LY +GG D +
Sbjct: 355 FNGSLRVRT-VDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTG-----L 408
Query: 514 RHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYSIWTNEPLACIQ 567
+++Y+ T++W + T ++ GV V G++Y VGGY + + L+ ++
Sbjct: 409 ASVEAYSYKTNEWFFVA-PMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVE 461
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 204 bits (518), Expect = 3e-52
Identities = 155/545 (28%), Positives = 251/545 (46%), Gaps = 33/545 (6%)
Query: 32 LNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADEVNLHGVTSL 91
+ + R G LCD+TL + KF AH+ VLAA YF AMF+ M+E DE+ + G+
Sbjct: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
Query: 92 GLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLA 151
L+ + FAY G + ++ +Q +L S LQL + + C +L + L+ N L + + A
Sbjct: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
Query: 152 DLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLA 211
+ +L A F+ +H E+ S EE L LP + E++ D L SEEQ+++ A
Sbjct: 148 ETMMCAVLYDAANSFIHQHFVEV--SMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAA 205
Query: 212 VRWLEHNCHYQ--YMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALVNEALEYHQ 269
+ W+ ++ + Y+ ELL IR L L LV+ LV+EA +YH
Sbjct: 206 LAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHL 265
Query: 270 SIYAQPVWQTRRTKPRFQSD---TLYIIGGKKREVCKVKELRYFNPVDQENALIAAIAN- 325
+P RT+PR + +Y +GG + + F+P IAN
Sbjct: 266 MPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDP----------IANC 315
Query: 326 WSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMK 385
W PM RS VAV+ L+ GG + T Y+P +++W + M
Sbjct: 316 WERCRPMTTARSRVGVAVVNGLLYAIGG-----YDGQLRLSTVEAYNPETDTWTRVGSMN 370
Query: 386 NCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVAD 445
+ R ++ +Y GG + L +VE Y P+ +KWT V S + S V +
Sbjct: 371 SKRSAMGTVVLDGQIYVCGGYDG-NSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFE 429
Query: 446 GLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLD 505
G +++SGG + Q + + Y + W + ML +R H A++ K++V GG D
Sbjct: 430 GRIYVSGG-HDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYD-- 486
Query: 506 YNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYSIWTNEPLAC 565
+ + Y+ DQW + T ++ + GR+Y VGGY +N L+
Sbjct: 487 ---GSGFLSIAEMYSSVADQWCLI-VPMHTRRSRVSLVASCGRLYAVGGYDGQSN--LSS 540
Query: 566 IQVLD 570
+++ D
Sbjct: 541 VEMYD 545
Score = 51.6 bits (122), Expect = 2e-06
Identities = 46/142 (32%), Positives = 63/142 (44%), Gaps = 13/142 (9%)
Query: 307 LRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVR 366
L+ F+ V+ N A W A M R H A +G +FV GG SG +
Sbjct: 441 LQIFSSVEHYNH---HTATWHPAAGMLNKRCRHGAASLGSKMFVCGGY--DGSG---FLS 492
Query: 367 TACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKW 426
A Y ++ W I PM R L A LYAVGG + + L +VE Y P+ + W
Sbjct: 493 IAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDG-QSNLSSVEMYDPETDCW 551
Query: 427 TFVQSFDRSLSCHAGYVADGLL 448
TF+ ++CH G V G +
Sbjct: 552 TFM----APMACHEGGVGVGCI 569
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 203 bits (516), Expect = 4e-52
Identities = 152/549 (27%), Positives = 265/549 (48%), Gaps = 25/549 (4%)
Query: 11 EMLTGQRLCHSESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAM 70
E T + +H + + LCD+ L+A +++ AH+ VL++ SDYF AM
Sbjct: 143 EPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAM 202
Query: 71 FSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNL 130
F+ + E+ +E+ + GV L +++AYTG++ L+ I+ +L+ LQL +++
Sbjct: 203 FTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEA 262
Query: 131 CSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLL 190
C +L+++L+ N L + AD T L K ++ ++H E++ R +E + LP +
Sbjct: 263 CCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVI--RNQEFVLLPASEI 320
Query: 191 QEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMD--ELLQYIRFGLMDVDTLHTVALSH 248
++L SD + +EE I + W+ H+ + D +LL YIR L+ L + ++
Sbjct: 321 AKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADME-NN 379
Query: 249 PLVQASETATALVNEALEYHQSIYAQPVWQTRRTKPRFQS-DTLYIIGGKKREVCKVKEL 307
L + L+ EA++YH +P+ Q+ RTKPR + TL+ +GG + K
Sbjct: 380 VLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGG----MDSTKGA 435
Query: 308 RYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRT 367
D + W+ +A M R VAV+ D L+V GG G
Sbjct: 436 TSIEKYDLRTNM------WTPVANMNGRRLQFGVAVLDDKLYVVGGR----DGLKTLNTV 485
Query: 368 ACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWT 427
C Y+P++ +W+ + PM R + +E +YAVGG + L TVER+ P+ +W
Sbjct: 486 EC-YNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGW-SYLNTVERWDPQARQWN 543
Query: 428 FVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYH 487
FV + S V G L+ GG ++ ++ + ++P+ NKW + M +RR
Sbjct: 544 FVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKS-VECFDPHTNKWTLCAQMSKRRGGV 602
Query: 488 SMAAVQRKLYVLGGNDLDYNN-DRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHN 546
+ LY +GG+D +N L ++ Y+ TD WT ++ ++ GV +
Sbjct: 603 GVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAV-ASMSISRDAVGVCLLG 661
Query: 547 GRIYLVGGY 555
++Y VGGY
Sbjct: 662 DKLYAVGGY 670
Score = 68.6 bits (166), Expect = 2e-11
Identities = 49/160 (30%), Positives = 68/160 (42%), Gaps = 11/160 (6%)
Query: 326 WSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMK 385
W+ +A M RS VAV+ L+ GG G +C C +DP +N W A M
Sbjct: 542 WNFVATMSTPRSTVGVAVLSGKLYAVGGR----DGSSCLKSVEC-FDPHTNKWTLCAQMS 596
Query: 386 NCREHFVLGAMEEYLYAVGGR-----NELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHA 440
R + LYA+GG N ++ VERY PK + WT V S S
Sbjct: 597 KRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG 656
Query: 441 GYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPM 480
+ L+ GG A Y N + Y+P N+W +P+
Sbjct: 657 VCLLGDKLYAVGGYDGQA-YLNTVEAYDPQTNEWTQVAPL 695
Score = 47.4 bits (111), Expect = 4e-05
Identities = 34/114 (29%), Positives = 55/114 (48%), Gaps = 7/114 (6%)
Query: 446 GLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLD 505
G L+ GG+ +T + + Y+ N W + M RR+ +A + KLYV+GG D
Sbjct: 421 GTLFAVGGMDST-KGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD-- 477
Query: 506 YNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYSIWT 559
+ ++ YN T W+ + T ++ GVAV G +Y VGG+ W+
Sbjct: 478 ---GLKTLNTVECYNPKTKTWSVMP-PMSTHRHGLGVAVLEGPMYAVGGHDGWS 527
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 203 bits (516), Expect = 4e-52
Identities = 152/549 (27%), Positives = 265/549 (48%), Gaps = 25/549 (4%)
Query: 11 EMLTGQRLCHSESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAM 70
E T + +H + + LCD+ L+A +++ AH+ VL++ SDYF AM
Sbjct: 189 EPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAM 248
Query: 71 FSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNL 130
F+ + E+ +E+ + GV L +++AYTG++ L+ I+ +L+ LQL +++
Sbjct: 249 FTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEA 308
Query: 131 CSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLL 190
C +L+++L+ N L + AD T L K ++ ++H E++ R +E + LP +
Sbjct: 309 CCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVI--RNQEFVLLPASEI 366
Query: 191 QEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMD--ELLQYIRFGLMDVDTLHTVALSH 248
++L SD + +EE I + W+ H+ + D +LL YIR L+ L + ++
Sbjct: 367 AKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADME-NN 425
Query: 249 PLVQASETATALVNEALEYHQSIYAQPVWQTRRTKPRFQS-DTLYIIGGKKREVCKVKEL 307
L + L+ EA++YH +P+ Q+ RTKPR + TL+ +GG + K
Sbjct: 426 VLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGG----MDSTKGA 481
Query: 308 RYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRT 367
D + W+ +A M R VAV+ D L+V GG G
Sbjct: 482 TSIEKYDLRTNM------WTPVANMNGRRLQFGVAVLDDKLYVVGGR----DGLKTLNTV 531
Query: 368 ACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWT 427
C Y+P++ +W+ + PM R + +E +YAVGG + L TVER+ P+ +W
Sbjct: 532 EC-YNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGW-SYLNTVERWDPQARQWN 589
Query: 428 FVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYH 487
FV + S V G L+ GG ++ ++ + ++P+ NKW + M +RR
Sbjct: 590 FVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKS-VECFDPHTNKWTLCAQMSKRRGGV 648
Query: 488 SMAAVQRKLYVLGGNDLDYNN-DRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHN 546
+ LY +GG+D +N L ++ Y+ TD WT ++ ++ GV +
Sbjct: 649 GVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAV-ASMSISRDAVGVCLLG 707
Query: 547 GRIYLVGGY 555
++Y VGGY
Sbjct: 708 DKLYAVGGY 716
Score = 68.6 bits (166), Expect = 2e-11
Identities = 49/160 (30%), Positives = 68/160 (42%), Gaps = 11/160 (6%)
Query: 326 WSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMK 385
W+ +A M RS VAV+ L+ GG G +C C +DP +N W A M
Sbjct: 588 WNFVATMSTPRSTVGVAVLSGKLYAVGGR----DGSSCLKSVEC-FDPHTNKWTLCAQMS 642
Query: 386 NCREHFVLGAMEEYLYAVGGR-----NELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHA 440
R + LYA+GG N ++ VERY PK + WT V S S
Sbjct: 643 KRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG 702
Query: 441 GYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPM 480
+ L+ GG A Y N + Y+P N+W +P+
Sbjct: 703 VCLLGDKLYAVGGYDGQA-YLNTVEAYDPQTNEWTQVAPL 741
Score = 47.4 bits (111), Expect = 4e-05
Identities = 34/114 (29%), Positives = 55/114 (48%), Gaps = 7/114 (6%)
Query: 446 GLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLD 505
G L+ GG+ +T + + Y+ N W + M RR+ +A + KLYV+GG D
Sbjct: 467 GTLFAVGGMDST-KGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD-- 523
Query: 506 YNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYSIWT 559
+ ++ YN T W+ + T ++ GVAV G +Y VGG+ W+
Sbjct: 524 ---GLKTLNTVECYNPKTKTWSVMP-PMSTHRHGLGVAVLEGPMYAVGGHDGWS 573
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 202 bits (515), Expect = 6e-52
Identities = 144/546 (26%), Positives = 259/546 (47%), Gaps = 40/546 (7%)
Query: 24 HNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADEV 83
H++ +L LN R LCDI L + K HAHK VLA+ S YF+AMF+ + E EV
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
Query: 84 NLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFN 143
+ L+ +E+AYTG + + ++ +L A + LQ+ +L C +L +L+ N
Sbjct: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
Query: 144 YLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLS 203
+ + R A+ + L A ++ ++ + ++ EE L + L E++ +D L +
Sbjct: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQT--EEFFELTHADLDEIVSNDCLNVAT 194
Query: 204 EEQIWQLAVRWLEHNC--HYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALV 261
EE ++ W++++ +Y+ +LL +R L+ V L + ++ L++ T L+
Sbjct: 195 EETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLL 254
Query: 262 NEALEYHQSIYAQPVWQT-RRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENALI 320
NEAL+YH + QT T+PR L +GGK + + + P +
Sbjct: 255 NEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQND----- 309
Query: 321 AAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEV----------EHASGRTCAVRTACR 370
+W LAP+ + R + V+ ++V GG +H + C
Sbjct: 310 ----SWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVEC------- 358
Query: 371 YDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQ 430
++P +N+W + M R + + LYA+GG + + L +VE+Y PK KW V
Sbjct: 359 WNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDG-QSYLQSVEKYIPKIRKWQPVA 417
Query: 431 SFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMA 490
+ SC A V DG+++ GG + N + Y+P+++ W + M +R++ +
Sbjct: 418 PMTTTRSCFAAAVLDGMIYAIGGY--GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVG 475
Query: 491 AVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIY 550
+ ++V+GG +N + I+ Y+ +QWT C + + G AV + +Y
Sbjct: 476 VMLGFIFVVGG-----HNGVSHLSSIERYDPHQNQWTVCR-PMKEPRTGVGAAVIDNYLY 529
Query: 551 LVGGYS 556
+VGG+S
Sbjct: 530 VVGGHS 535
Score = 85.5 bits (210), Expect = 1e-16
Identities = 50/173 (28%), Positives = 83/173 (47%), Gaps = 8/173 (4%)
Query: 320 IAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWA 379
I I W +APM RS AV+ ++ GG + + RYDP +SW
Sbjct: 407 IPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY------GPAHMNSVERYDPSKDSWE 460
Query: 380 EIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCH 439
+A M + R HF +G M +++ VGG N + L ++ERY P +N+WT + +
Sbjct: 461 MVASMADKRIHFGVGVMLGFIFVVGGHNGVSH-LSSIERYDPHQNQWTVCRPMKEPRTGV 519
Query: 440 AGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAV 492
V D L++ GG + ++ Y N + Y+P + W+ + M+ R + A+
Sbjct: 520 GAAVIDNYLYVVGGHSGSS-YLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571
Score = 40.0 bits (92), Expect = 0.006
Identities = 29/106 (27%), Positives = 52/106 (49%), Gaps = 15/106 (14%)
Query: 291 LYIIGGKKREVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFV 350
++++GG V + + ++P + W+ PM R+ AV+ ++L+V
Sbjct: 481 IFVVGGHNG-VSHLSSIERYDPHQNQ---------WTVCRPMKEPRTGVGAAVIDNYLYV 530
Query: 351 AGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAM 396
GG SG + + T +YDP S++W + A M CR +F L A+
Sbjct: 531 VGGH----SGSSY-LNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 201 bits (512), Expect = 1e-51
Identities = 159/565 (28%), Positives = 259/565 (45%), Gaps = 58/565 (10%)
Query: 24 HNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADEV 83
H +N+ RS +LCD+T++AE+ + AH+ VLAACS YF AMF+ M ES A V
Sbjct: 42 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 101
Query: 84 NLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFN 143
+ V L+ +++ YT +I + +Q +L A LQL ++ C +L +L+ N
Sbjct: 102 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 161
Query: 144 YLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLS 203
L + AD+ T L + +H ++++ S EE L L + ++ SD+LT S
Sbjct: 162 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLS--EEFLNLGIEQVCSLISSDKLTISS 219
Query: 204 EEQIWQLAVRWLEH--NCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALV 261
EE++++ + W+ H + ++M L++++R L+ + L LV+ S +
Sbjct: 220 EEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYL 279
Query: 262 NEALEYH-----QSIYAQPVWQTRRTKPRFQSDTLYIIGG------KKREVCKVKELRYF 310
EA++YH Q I + V +TR P + ++GG + E KE R+
Sbjct: 280 IEAMKYHLLPTEQRILMKSV-RTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWH 338
Query: 311 NPVDQEN-----------ALIAAIA-------------------NWSELAPMPVGRSHHC 340
+ + L+ A+ W+ +A M RS
Sbjct: 339 QVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLG 398
Query: 341 VAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYL 400
AV+ L+ GG G T + + Y+ +SN W +APM R +G + L
Sbjct: 399 AAVLNGLLYAVGG----FDGST-GLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLL 453
Query: 401 YAVGGRN-ELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQ 459
YAVGG + RQ L TVE Y N+WT++ S V + LL+ GG +
Sbjct: 454 YAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG-HDGPL 512
Query: 460 YQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSY 519
+ + VY+P N W + M R + AV LYV+GG+D N + ++ Y
Sbjct: 513 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN-----LASVEYY 567
Query: 520 NIDTDQWTRCNFNLLTGQNESGVAV 544
N TD+WT + + TG++ +GV V
Sbjct: 568 NPTTDKWTVVSSCMSTGRSYAGVTV 592
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 201 bits (512), Expect = 1e-51
Identities = 159/565 (28%), Positives = 259/565 (45%), Gaps = 58/565 (10%)
Query: 24 HNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADEV 83
H +N+ RS +LCD+T++AE+ + AH+ VLAACS YF AMF+ M ES A V
Sbjct: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
Query: 84 NLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFN 143
+ V L+ +++ YT +I + +Q +L A LQL ++ C +L +L+ N
Sbjct: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
Query: 144 YLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLS 203
L + AD+ T L + +H ++++ S EE L L + ++ SD+LT S
Sbjct: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLS--EEFLNLGIEQVCSLISSDKLTISS 215
Query: 204 EEQIWQLAVRWLEH--NCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALV 261
EE++++ + W+ H + ++M L++++R L+ + L LV+ S +
Sbjct: 216 EEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYL 275
Query: 262 NEALEYH-----QSIYAQPVWQTRRTKPRFQSDTLYIIGG------KKREVCKVKELRYF 310
EA++YH Q I + V +TR P + ++GG + E KE R+
Sbjct: 276 IEAMKYHLLPTEQRILMKSV-RTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWH 334
Query: 311 NPVDQEN-----------ALIAAIA-------------------NWSELAPMPVGRSHHC 340
+ + L+ A+ W+ +A M RS
Sbjct: 335 QVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLG 394
Query: 341 VAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYL 400
AV+ L+ GG G T + + Y+ +SN W +APM R +G + L
Sbjct: 395 AAVLNGLLYAVGG----FDGST-GLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLL 449
Query: 401 YAVGGRN-ELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQ 459
YAVGG + RQ L TVE Y N+WT++ S V + LL+ GG +
Sbjct: 450 YAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG-HDGPL 508
Query: 460 YQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSY 519
+ + VY+P N W + M R + AV LYV+GG+D N + ++ Y
Sbjct: 509 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN-----LASVEYY 563
Query: 520 NIDTDQWTRCNFNLLTGQNESGVAV 544
N TD+WT + + TG++ +GV V
Sbjct: 564 NPTTDKWTVVSSCMSTGRSYAGVTV 588
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 201 bits (511), Expect = 2e-51
Identities = 149/553 (26%), Positives = 261/553 (47%), Gaps = 26/553 (4%)
Query: 21 SESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGA 80
+ +H S+L ++N R LCD+TL E++ F AH+ VLAACSDYF AMF+ + E G
Sbjct: 12 TNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGK 71
Query: 81 DEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELN 140
V++ G+T+ ++ L+F YT + + +Q++L A LQL + C +L +L+
Sbjct: 72 PYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLD 131
Query: 141 SFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLT 200
N L + A+ N L +A F KH E+++ EE + L +++++K D +
Sbjct: 132 PSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQH--EEFILLSQGEVEKLIKCDEIQ 189
Query: 201 SLSEEQIWQLAVRWLEH--NCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETAT 258
SEE +++ + W++H + + LLQY+R L+ + V + P ++ S
Sbjct: 190 VDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCR 249
Query: 259 ALVNEALEYHQSIYAQPVWQTRRTKPRF-QSDTLYIIGGKKREVCKVKELRYFNPVDQEN 317
LV+EA ++H + Q RT+ R ++ L ++GG + + + ++P QE
Sbjct: 250 DLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQE- 308
Query: 318 ALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNS 377
WS L + R + + D ++V GG R +V
Sbjct: 309 --------WSFLPSITRKRRYVASVSLHDRIYVIGG--YDGRSRLSSVECLDYTADEDGV 358
Query: 378 WAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLS 437
W +APM R + + +Y GG + R+ ++ERY P ++W+ + +
Sbjct: 359 WYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRR-HTSMERYDPNIDQWSMLGDMQTARE 417
Query: 438 CHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLY 497
VA G+++ GG + N + Y+P+ W + +PM +R +A + +Y
Sbjct: 418 GAGLVVASGVIYCLGGY-DGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIY 476
Query: 498 VLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYSI 557
V+GG D + +++YNI TD WT ++ T + G V GR+Y + GY
Sbjct: 477 VVGGFD-----GTAHLSSVEAYNIRTDSWTTVT-SMTTPRCYVGATVLRGRLYAIAGYD- 529
Query: 558 WTNEPLACIQVLD 570
N L+ I+ D
Sbjct: 530 -GNSLLSSIECYD 541
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 198 bits (504), Expect = 1e-50
Identities = 160/565 (28%), Positives = 270/565 (47%), Gaps = 28/565 (4%)
Query: 20 HSESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESG 79
H +H + L + + LCD+ LIA + AH+ VL+A SDYF AMF+ ++E+
Sbjct: 160 HVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAK 219
Query: 80 ADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQEL 139
+EV + GV L +++AYTG + L+ I+ +LAA LQL +++++CS++LI++L
Sbjct: 220 QEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQL 279
Query: 140 NSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRL 199
+ N L + D T L + ++H E++K+ +E L LP + ++L SD +
Sbjct: 280 HPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKN--QEFLLLPANEISKLLCSDDI 337
Query: 200 TSLSEEQIWQLAVRWLEHNCHYQY--MDELLQYIRFGLMDVDTLHTVALSHPLVQASETA 257
EE I+ ++W+ H+ + + LL YIR L+ L + S E
Sbjct: 338 NVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLE-C 396
Query: 258 TALVNEALEYHQSIYAQPVWQTRRTKPRFQS-DTLYIIGGKKREVCKVKELRYFNPVDQE 316
L+ EA++YH + + Q+ RTKPR + LY +GG + ++ +++
Sbjct: 397 QKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGG-------MDAMKGTTTIEKY 449
Query: 317 NALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSN 376
+ +W + M R VAV+ + L+V GG G C ++P
Sbjct: 450 D---LRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGR----DGLKTLNTVEC-FNPVGK 501
Query: 377 SWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSL 436
W + PM R + +E +YAVGG + L TVER+ P+ +W +V S
Sbjct: 502 IWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGW-SYLNTVERWDPEGRQWNYVASMSTPR 560
Query: 437 SCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKL 496
S + L+ GG ++ ++ + ++P+ NKW +PM +RR +A L
Sbjct: 561 STVGVVALNNKLYAIGGRDGSSCLKS-MEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFL 619
Query: 497 YVLGGNDLDYNND-RILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGY 555
YV+GG+D +N L ++ Y+ D W+ L ++ V ++Y+VGGY
Sbjct: 620 YVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTV-APLSVPRDAVAVCPLGDKLYVVGGY 678
Query: 556 SIWTNEPLACIQVLDVSR-EGKEEV 579
T L ++ D R E KEEV
Sbjct: 679 DGHTY--LNTVESYDAQRNEWKEEV 701
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 195 bits (496), Expect = 9e-50
Identities = 151/540 (27%), Positives = 259/540 (47%), Gaps = 25/540 (4%)
Query: 20 HSESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESG 79
H +H + L + + LCD+ LIA + AH+ VL+A SDYF AMF+ ++E+
Sbjct: 160 HVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAK 219
Query: 80 ADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQEL 139
+EV + GV L +++AYTG + L+ I+ +LAA LQL +++++CS++LI++L
Sbjct: 220 QEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQL 279
Query: 140 NSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRL 199
+ N L + D T L + ++H E++K+ +E L LP + ++L SD +
Sbjct: 280 HPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKN--QEFLLLPANEISKLLCSDDI 337
Query: 200 TSLSEEQIWQLAVRWLEHNCHYQY--MDELLQYIRFGLMDVDTLHTVALSHPLVQASETA 257
EE I+ ++W+ H+ + + LL YIR L+ L + S E
Sbjct: 338 NVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLE-C 396
Query: 258 TALVNEALEYHQSIYAQPVWQTRRTKPRFQS-DTLYIIGGKKREVCKVKELRYFNPVDQE 316
L+ EA++YH + + Q+ RTKPR + LY +GG + ++ +++
Sbjct: 397 QKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGG-------MDAMKGTTTIEKY 449
Query: 317 NALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSN 376
+ +W + M R VAV+ + L+V GG G C ++P
Sbjct: 450 D---LRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGR----DGLKTLNTVEC-FNPVGK 501
Query: 377 SWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSL 436
W + PM R + +E +YAVGG + L TVER+ P+ +W +V S
Sbjct: 502 IWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGW-SYLNTVERWDPEGRQWNYVASMSTPR 560
Query: 437 SCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKL 496
S + L+ GG ++ ++ + ++P+ NKW +PM +RR +A L
Sbjct: 561 STVGVVALNNKLYAIGGRDGSSCLKS-MEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFL 619
Query: 497 YVLGGNDLDYNND-RILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGY 555
YV+GG+D +N L ++ Y+ D W+ L ++ V ++Y+VGGY
Sbjct: 620 YVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTV-APLSVPRDAVAVCPLGDKLYVVGGY 678
Score = 43.1 bits (100), Expect = 8e-04
Identities = 31/114 (27%), Positives = 52/114 (45%), Gaps = 7/114 (6%)
Query: 446 GLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLD 505
G L+ GG+ + + + Y+ N W+ M RR+ +A + KLYV+GG D
Sbjct: 429 GALYAVGGM-DAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRD-- 485
Query: 506 YNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYSIWT 559
+ ++ +N WT + T ++ GVA G +Y VGG+ W+
Sbjct: 486 ---GLKTLNTVECFNPVGKIWTVMP-PMSTHRHGLGVATLEGPMYAVGGHDGWS 535
Score = 36.6 bits (83), Expect = 0.071
Identities = 20/56 (35%), Positives = 27/56 (48%), Gaps = 5/56 (8%)
Query: 325 NWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAE 380
+WS +AP+ V R V +GD L+V GG H + T YD + N W E
Sbjct: 649 SWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHT-----YLNTVESYDAQRNEWKE 699
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 187 bits (474), Expect = 3e-47
Identities = 140/544 (25%), Positives = 244/544 (44%), Gaps = 38/544 (6%)
Query: 22 ESHNDSVLAALNQQRSDGILCDITLIAEEQ-----KFHAHKAVLAACSDYFRAMFSLCMV 76
E H +N+ R LCD+TL + Q +F AHK VLA+ S F+AMF+ +
Sbjct: 57 EDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLR 116
Query: 77 ESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLI 136
E G + V++ G+ +++ +EFAYT I + + V+ Q+ ++ CS +L+
Sbjct: 117 EQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLV 176
Query: 137 QELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKS 196
Q+L+ N + + A+ L + +++ H E+ K EE L +C L ++
Sbjct: 177 QQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQ--EEFFNLSHCQLVTLISR 234
Query: 197 DRLTSLSEEQIWQLAVRWLEHNCHYQ--YMDELLQYIRFGLMDVDTLHTVALSHPLVQAS 254
D L E +++ + W++++C + Y+ LL+ +R + + L ++Q+
Sbjct: 235 DDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSD 294
Query: 255 ETA---TALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFN 311
+ E L H+ P + + +Y GG R+ + L +N
Sbjct: 295 SRCKDYLVKIFEELTLHKPTQVMPCRAPKVGR------LIYTAGGYFRQ--SLSYLEAYN 346
Query: 312 PVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRY 371
P D W LA + V RS V+G L+ GG G T + C Y
Sbjct: 347 PSD---------GTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDC-Y 396
Query: 372 DPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQS 431
+P +N W+ APM R +G ++ ++YAVGG + +VERY P++++W V
Sbjct: 397 NPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIH-HNSVERYEPERDEWHLVAP 455
Query: 432 FDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAA 491
V + LL+ GG T + N Y P +N+W + M R +
Sbjct: 456 MLTRRIGVGVAVLNRLLYAVGGFDGTNRL-NSAECYYPERNEWRMITAMNTIRSGAGVCV 514
Query: 492 VQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYL 551
+ +Y GG D D++ ++ Y+++T+ WT + ++ G+ VH GRIY+
Sbjct: 515 LHNCIYAAGGYD---GQDQL--NSVERYDVETETWTFV-APMKHRRSALGITVHQGRIYV 568
Query: 552 VGGY 555
+GGY
Sbjct: 569 LGGY 572
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 187 bits (474), Expect = 3e-47
Identities = 140/544 (25%), Positives = 244/544 (44%), Gaps = 38/544 (6%)
Query: 22 ESHNDSVLAALNQQRSDGILCDITLIAEEQ-----KFHAHKAVLAACSDYFRAMFSLCMV 76
E H +N+ R LCD+TL + Q +F AHK VLA+ S F+AMF+ +
Sbjct: 57 EDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLR 116
Query: 77 ESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLI 136
E G + V++ G+ +++ +EFAYT I + + V+ Q+ ++ CS +L+
Sbjct: 117 EQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLV 176
Query: 137 QELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKS 196
Q+L+ N + + A+ L + +++ H E+ K EE L +C L ++
Sbjct: 177 QQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQ--EEFFNLSHCQLVTLISR 234
Query: 197 DRLTSLSEEQIWQLAVRWLEHNCHYQ--YMDELLQYIRFGLMDVDTLHTVALSHPLVQAS 254
D L E +++ + W++++C + Y+ LL+ +R + + L ++Q+
Sbjct: 235 DDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSD 294
Query: 255 ETA---TALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFN 311
+ E L H+ P + + +Y GG R+ + L +N
Sbjct: 295 SRCKDYLVKIFEELTLHKPTQVMPCRAPKVGR------LIYTAGGYFRQ--SLSYLEAYN 346
Query: 312 PVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRY 371
P D W LA + V RS V+G L+ GG G T + C Y
Sbjct: 347 PSD---------GTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDC-Y 396
Query: 372 DPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQS 431
+P +N W+ APM R +G ++ ++YAVGG + +VERY P++++W V
Sbjct: 397 NPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIH-HNSVERYEPERDEWHLVAP 455
Query: 432 FDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAA 491
V + LL+ GG T + N Y P +N+W + M R +
Sbjct: 456 MLTRRIGVGVAVLNRLLYAVGGFDGTNRL-NSAECYYPERNEWRMITAMNTIRSGAGVCV 514
Query: 492 VQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYL 551
+ +Y GG D D++ ++ Y+++T+ WT + ++ G+ VH GRIY+
Sbjct: 515 LHNCIYAAGGYD---GQDQL--NSVERYDVETETWTFV-APMKHRRSALGITVHQGRIYV 568
Query: 552 VGGY 555
+GGY
Sbjct: 569 LGGY 572
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 186 bits (471), Expect = 7e-47
Identities = 151/574 (26%), Positives = 259/574 (45%), Gaps = 60/574 (10%)
Query: 2 PSERCLSIQEMLTGQRLCHSESHNDSVLA-ALNQQRSDGILCDITLIAEEQKFHAHKAVL 60
PS++ + E+L G+++ ++ +L L R + L D+ L + Q+F H+ VL
Sbjct: 31 PSQKTGDLVEILNGEKVKFDDAGLSLILQNGLETLRMENALTDVILCVDIQEFSCHRVVL 90
Query: 61 AACSDYFRAMFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGS 120
AA S+YFRAMF + E + + GV + + L++ YT + L+ +Q VL A +
Sbjct: 91 AAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAAN 150
Query: 121 HLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPE 180
Q L +++ C+ +L + LN N + + RLAD +L L+K V +++++ ++L S E
Sbjct: 151 LFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNS--E 208
Query: 181 EVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN-----CHYQYMDELLQYIRFGL 235
E L LP L +LKSD L E Q+++ + W+ H C Y +L+ +R L
Sbjct: 209 EFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPY---VLENVRLPL 265
Query: 236 MDVDTLHTVALSHPLVQASETATALVNEALEYHQSIYAQPVWQTRRTKPR---FQSDTLY 292
+D + PL++ L+ EA YH S + RTKPR FQS+
Sbjct: 266 LDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLS---GNEIISERTKPRMHEFQSEVFM 322
Query: 293 IIGGKKREVCKVKELRYFNPVDQENALIAAI-----------ANWSELAPMPVGRSHHCV 341
IIGG ++ V E+ +P+ + +A + W E A CV
Sbjct: 323 IIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFA---------CV 373
Query: 342 AVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLY 401
+ + G E +H +Y+ N W +I + R + + +Y
Sbjct: 374 TLKNEVYISGGKETQH---------DVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVY 424
Query: 402 AVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQ 461
+GG + L+++ VE Y P N W+ +S A L++ GG N
Sbjct: 425 VIGGFDGLQRI-NNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLAT 483
Query: 462 NRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNI 521
++ Y+P+ NKW ++ M + + + ++YV+GG +R + +Y+
Sbjct: 484 DKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG----------AMRALYAYSP 533
Query: 522 DTDQWTRCNFNLLTGQNES-GVAVHNGRIYLVGG 554
D W C L+ + S G+A N R+Y+ GG
Sbjct: 534 LEDSW--CLVTQLSHERASCGIAPCNNRLYITGG 565
Score = 50.1 bits (118), Expect = 6e-06
Identities = 48/207 (23%), Positives = 83/207 (40%), Gaps = 14/207 (6%)
Query: 291 LYIIGGKKREVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFV 350
+ ++GGK + L+ N V+ + WSE AP+ V S L+V
Sbjct: 416 MVVLGGKVYVIGGFDGLQRINNVETYDPFHNC---WSEAAPLLVHVSSFAATSHKKKLYV 472
Query: 351 AGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELR 410
GG +G+ +T C YDP +N W+ A M + + + +Y VGG
Sbjct: 473 IGGG---PNGKLATDKTQC-YDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG----- 523
Query: 411 QVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPN 470
+ + Y P ++ W V + + L+I+GG + ++ ++P
Sbjct: 524 -AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPE 582
Query: 471 QNKWISRSPMLQRRVYHSMAAVQRKLY 497
K ++ +L R V H + RK Y
Sbjct: 583 AQK-LTEECVLPRGVSHHGSVTIRKSY 608
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 185 bits (469), Expect = 1e-46
Identities = 142/503 (28%), Positives = 246/503 (48%), Gaps = 25/503 (4%)
Query: 57 KAVLAACSDYFRAMFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVL 116
+ VL++ SDYF AMF+ + E+ +E+ + GV L +++AYTG++ L+ I+ +L
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 117 AAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLK 176
+ LQL +++ C +L+++L+ N L + AD T L K ++ ++H E++
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVI- 292
Query: 177 SRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMD--ELLQYIRFG 234
R +E + LP + ++L SD + +EE I + W+ H+ + D +LL YIR
Sbjct: 293 -RNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLP 351
Query: 235 LMDVDTLHTVALSHPLVQASETATALVNEALEYHQSIYAQPVWQTRRTKPRFQS-DTLYI 293
L+ L + ++ L + L+ EA++YH +P+ Q+ RTKPR + TL+
Sbjct: 352 LLAPQFLADME-NNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFA 410
Query: 294 IGGKKREVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGG 353
+GG + K D + W+ +A M R VAV+ D L+V GG
Sbjct: 411 VGG----MDSTKGATSIEKYDLRTNM------WTPVANMNGRRLQFGVAVLDDKLYVVGG 460
Query: 354 EVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVL 413
G C Y+P++ +W+ + PM R + +E +YAVGG + L
Sbjct: 461 R----DGLKTLNTVEC-YNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGW-SYL 514
Query: 414 PTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNK 473
TVER+ P+ +W FV + S V G L+ GG ++ ++ + ++P+ NK
Sbjct: 515 NTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKS-VECFDPHTNK 573
Query: 474 WISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNN-DRILVRHIDSYNIDTDQWTRCNFN 532
W + M +RR + LY +GG+D +N L ++ Y+ TD WT +
Sbjct: 574 WTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAV-AS 632
Query: 533 LLTGQNESGVAVHNGRIYLVGGY 555
+ ++ GV + ++Y VGGY
Sbjct: 633 MSISRDAVGVCLLGDKLYAVGGY 655
Score = 68.6 bits (166), Expect = 2e-11
Identities = 49/160 (30%), Positives = 68/160 (42%), Gaps = 11/160 (6%)
Query: 326 WSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMK 385
W+ +A M RS VAV+ L+ GG G +C C +DP +N W A M
Sbjct: 527 WNFVATMSTPRSTVGVAVLSGKLYAVGGR----DGSSCLKSVEC-FDPHTNKWTLCAQMS 581
Query: 386 NCREHFVLGAMEEYLYAVGGR-----NELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHA 440
R + LYA+GG N ++ VERY PK + WT V S S
Sbjct: 582 KRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG 641
Query: 441 GYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPM 480
+ L+ GG A Y N + Y+P N+W +P+
Sbjct: 642 VCLLGDKLYAVGGYDGQA-YLNTVEAYDPQTNEWTQVAPL 680
Score = 47.4 bits (111), Expect = 4e-05
Identities = 34/114 (29%), Positives = 55/114 (48%), Gaps = 7/114 (6%)
Query: 446 GLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLD 505
G L+ GG+ +T + + Y+ N W + M RR+ +A + KLYV+GG D
Sbjct: 406 GTLFAVGGMDST-KGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD-- 462
Query: 506 YNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYSIWT 559
+ ++ YN T W+ + T ++ GVAV G +Y VGG+ W+
Sbjct: 463 ---GLKTLNTVECYNPKTKTWSVMP-PMSTHRHGLGVAVLEGPMYAVGGHDGWS 512
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 178 bits (451), Expect = 2e-44
Identities = 150/551 (27%), Positives = 250/551 (45%), Gaps = 39/551 (7%)
Query: 18 LCHSESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVE 77
L H SH D VLA LN R + D+TL A ++ F H+AVLAA S YF AMFS + E
Sbjct: 22 LFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRE 81
Query: 78 SGADEVNLH-GVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLI 136
S D VN + L+ L+FAY+ +I + + +L AG LQ ++ + + +L
Sbjct: 82 SRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Query: 137 QELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKS 196
+ L N L + L+D L + + H + +S E+ +L L +++ S
Sbjct: 142 KNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQS--EDFNSLSKDTLLDLISS 199
Query: 197 DRLTSLSEEQIWQLAVRWLEHNCHYQ--YMDELLQYIRFGLMDVDTLHTVALSHPLVQAS 254
D L + E +++ ++W++H+ + ++ ELL+ +R L+ D L S L+ A
Sbjct: 200 DELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMAD 259
Query: 255 ETATALVNEALEYHQSIYAQP-VWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPV 313
E +++EAL I V + +PR TL I+GG+ K+ + V
Sbjct: 260 ERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQ------V 313
Query: 314 DQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDP 373
D + I A+ +P R + +G ++V GG + YD
Sbjct: 314 DHKAKEIIPKAD------LPSPRKEFSASAIGCKVYVTGGR----GSENGVSKDVWVYDT 363
Query: 374 RSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPT--------VERYCPKKNK 425
W++ APM R +E LY VGG L V P VE+Y P NK
Sbjct: 364 VHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANK 423
Query: 426 WTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRV 485
W V +S A A L++ GG + +++ Y+P++N+W ++ Q
Sbjct: 424 WMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWR 483
Query: 486 YHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVH 545
Y + A + +++++GG + ++ +T+QWTR +T + S A+
Sbjct: 484 YTAAAVLGSQIFIMGG------DTEFTAASAYRFDCETNQWTR--IGDMTAKRMSCHALA 535
Query: 546 NG-RIYLVGGY 555
+G ++Y+VGGY
Sbjct: 536 SGNKLYVVGGY 546
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 175 bits (444), Expect = 1e-43
Identities = 129/506 (25%), Positives = 230/506 (45%), Gaps = 36/506 (7%)
Query: 29 LAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADEVNLHGV 88
+ +N R LCD+ L+ +E+K AH+ VLAA S +F MF+ M+ES + EV L
Sbjct: 31 MGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDA 90
Query: 89 TSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLY 148
++Q +EFAYT +I + +Q +L A + Q+ + +C +L +++++ N L +
Sbjct: 91 EPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGIS 150
Query: 149 RLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIW 208
LA+ + L+ DF+ +H +E+ K+ +E L L + +L D LT +E+Q++
Sbjct: 151 VLAECLDCPELKATADDFIHQHFTEVYKT--DEFLQLDVKRVTHLLNQDTLTVRAEDQVY 208
Query: 209 QLAVRWLEHN--CHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALVNEALE 266
AVRWL+++ +M ++L +RF L+ + L + PL+Q + +V +
Sbjct: 209 DAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMR 268
Query: 267 YHQSIYAQPVWQTRRTKPRFQSD--TLYIIGGKKREVCKVKELRYFNPVDQENALIAAIA 324
YH T+PR + + + GG + + C RYFNP D
Sbjct: 269 YHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSC-----RYFNPKDY--------- 314
Query: 325 NWSEL-APMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAP 383
+W+++ P R CV + +++ GG + ++ Y+ +SW
Sbjct: 315 SWTDIRCPFEKRRDAACV-FWDNVVYILGG------SQLFPIKRMDCYNVVKDSWYSKLG 367
Query: 384 MKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYV 443
R+ A E +Y GG L E Y + W S H
Sbjct: 368 PPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVE 427
Query: 444 ADGLLWISGGVTN---TAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLG 500
A+GL+++ GG + + N VY+P W PM++ R H + V+ K++ +G
Sbjct: 428 ANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVG 487
Query: 501 GNDLDYNNDRILVRHIDSYNIDTDQW 526
G N + +++ Y+I ++W
Sbjct: 488 G-----QNGLGGLDNVEYYDIKLNEW 508
Score = 34.7 bits (78), Expect = 0.27
Identities = 32/134 (23%), Positives = 58/134 (43%), Gaps = 7/134 (5%)
Query: 421 PKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPM 480
PK WT ++ A D +++I GG + R+ Y ++ W S+
Sbjct: 311 PKDYSWTDIRCPFEKRRDAACVFWDNVVYILGG--SQLFPIKRMDCYNVVKDSWYSKLGP 368
Query: 481 LQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNES 540
R + A + K+Y GG+++ N + + + Y+ T+ W ++LT +
Sbjct: 369 PTPRDSLAACAAEGKIYTSGGSEV--GNSALYL--FECYDTRTESW-HTKPSMLTQRCSH 423
Query: 541 GVAVHNGRIYLVGG 554
G+ NG IY+ GG
Sbjct: 424 GMVEANGLIYVCGG 437
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 174 bits (441), Expect = 2e-43
Identities = 136/536 (25%), Positives = 245/536 (45%), Gaps = 35/536 (6%)
Query: 23 SHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADE 82
SH +++L N+ R + D+ + E ++F H+AVL+ACS YFRAMF ES
Sbjct: 47 SHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREML 106
Query: 83 VNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSF 142
V ++G+ + ++ L++ YTG++ + +Q + S Q+ L + C+ +L ++L+
Sbjct: 107 VEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPC 166
Query: 143 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSL 202
N L + R AD +L L +F ++ ++ S+ EE L L L + + SD L
Sbjct: 167 NCLGIQRFADTHSLKTLFTKCKNFALQTFEDV--SQHEEFLELDKDELIDYICSDELVIG 224
Query: 203 SEEQIWQLAVRWLEH--NCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATAL 260
EE +++ +RW+ + + ELL ++R L+ + L+Q S L
Sbjct: 225 KEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQL 284
Query: 261 VNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKR-EVCKVKELRYFNPVDQENAL 319
++EA YH +TR + S+ + ++GG +R + ++PV E
Sbjct: 285 LHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGE--- 341
Query: 320 IAAIANWSELAPMP-VGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSW 378
W LA +P +S + V + + + V+GG + R Y+ + N W
Sbjct: 342 ------WKSLAKLPEFTKSEYAVCALRNDILVSGGRINS--------RDVWIYNSQLNIW 387
Query: 379 AEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSC 438
+A + R + + +Y VGG + + L +VE Y N+WT V ++S
Sbjct: 388 IRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNR-LSSVECYDSFSNRWTEVAPLKEAVSS 446
Query: 439 HAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYV 498
A G L++ GG + +++ Y+P N W+ R+ + + + ++ +YV
Sbjct: 447 PAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYV 506
Query: 499 LGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGG 554
GG L + I Y+ D W N + Q G++V NG+IY++GG
Sbjct: 507 AGG----------LTKAIYCYDPVEDYWMHVQ-NTFSRQENCGMSVCNGKIYILGG 551
Score = 37.7 bits (86), Expect = 0.032
Identities = 30/149 (20%), Positives = 60/149 (40%), Gaps = 19/149 (12%)
Query: 291 LYIIGGKKREVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFV 350
L++IGG + +++ ++P +W A +P+ + + + ++V
Sbjct: 456 LFVIGGGPDDNTCSDKVQSYDPETN---------SWLLRAAIPIAKRCITAVSLNNLIYV 506
Query: 351 AGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELR 410
AGG + YDP + W + + +E+ + +Y +GGR E
Sbjct: 507 AGG----------LTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENG 556
Query: 411 QVLPTVERYCPKKNKWTFVQSFDRSLSCH 439
+ T+ Y P + T V + R +S H
Sbjct: 557 EATDTILCYDPATSIITGVAAMPRPVSYH 585
Score = 33.1 bits (74), Expect = 0.78
Identities = 26/91 (28%), Positives = 45/91 (49%), Gaps = 12/91 (13%)
Query: 467 YEPNQNKW--ISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTD 524
Y+P +W +++ P + Y ++ A++ + V GG RI R + YN +
Sbjct: 335 YDPVTGEWKSLAKLPEFTKSEY-AVCALRNDILVSGG--------RINSRDVWIYNSQLN 385
Query: 525 QWTRCNFNLLTGQNESGVAVHNGRIYLVGGY 555
W R +L G+ +AV G++Y+VGGY
Sbjct: 386 IWIRVA-SLNKGRWRHKMAVLLGKVYVVGGY 415
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,596,337
Number of Sequences: 37866
Number of extensions: 1024546
Number of successful extensions: 3324
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 164
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 2065
Number of HSP's gapped (non-prelim): 371
length of query: 620
length of database: 18,247,518
effective HSP length: 108
effective length of query: 512
effective length of database: 14,157,990
effective search space: 7248890880
effective search space used: 7248890880
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.