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Search of human proteins with 11056006
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11056006 kelch-like 12 [Homo sapiens]
(568 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11056006 kelch-like 12 [Homo sapiens] 1153 0.0
gi|40807500 kelch-like 20 [Homo sapiens] 485 e-137
gi|166235129 kelch-like 3 [Homo sapiens] 441 e-124
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 437 e-123
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 437 e-123
gi|38194229 kelch-like 17 [Homo sapiens] 429 e-120
gi|55925604 kelch-like 18 [Homo sapiens] 424 e-119
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 415 e-116
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 415 e-116
gi|34101268 kelch-like 8 [Homo sapiens] 409 e-114
gi|14780904 kelch-like 1 protein [Homo sapiens] 408 e-114
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 399 e-111
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 395 e-110
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 395 e-110
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 384 e-106
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 380 e-105
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 365 e-101
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 365 e-101
gi|148664209 kelch-like 10 [Homo sapiens] 350 2e-96
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 337 2e-92
gi|223890235 intracisternal A particle-promoted polypeptide isof... 312 5e-85
gi|40018614 DRE1 protein [Homo sapiens] 302 6e-82
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 293 2e-79
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 288 9e-78
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 274 1e-73
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 274 1e-73
gi|109150407 kelch-like 6 [Homo sapiens] 268 1e-71
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 258 1e-68
gi|24308181 kelch-like 9 [Homo sapiens] 250 3e-66
gi|55925608 kelch-like 21 [Homo sapiens] 249 6e-66
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 1153 bits (2982), Expect = 0.0
Identities = 568/568 (100%), Positives = 568/568 (100%)
Query: 1 MGGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCA 60
MGGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCA
Sbjct: 1 MGGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCA 60
Query: 61 MFTSELSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQ 120
MFTSELSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQ
Sbjct: 61 MFTSELSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQ 120
Query: 121 ACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVE 180
ACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVE
Sbjct: 121 ACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVE 180
Query: 181 KLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEP 240
KLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEP
Sbjct: 181 KLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEP 240
Query: 241 FIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVE 300
FIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVE
Sbjct: 241 FIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVE 300
Query: 301 KYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWY 360
KYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWY
Sbjct: 301 KYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWY 360
Query: 361 SVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAG 420
SVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAG
Sbjct: 361 SVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAG 420
Query: 421 LVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGG 480
LVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGG
Sbjct: 421 LVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGG 480
Query: 481 FDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECY 540
FDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECY
Sbjct: 481 FDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECY 540
Query: 541 DPIIDSWEVVTSMGTQRCDAGVCVLREK 568
DPIIDSWEVVTSMGTQRCDAGVCVLREK
Sbjct: 541 DPIIDSWEVVTSMGTQRCDAGVCVLREK 568
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 485 bits (1248), Expect = e-137
Identities = 251/559 (44%), Positives = 353/559 (63%), Gaps = 7/559 (1%)
Query: 11 MTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKG 70
+++ H + L +N LRK LCDV L V K AHR++L+ACS YF AMFT EL+E
Sbjct: 46 ISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESR 105
Query: 71 KPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQL 130
+ V I+ + ME+L+DF YT + V NVQ LLPAACLLQL +++ACCEFL+ QL
Sbjct: 106 QTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQL 165
Query: 131 DPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQV 190
DPSNCLGIR FA+TH+C +L++ A+ F+Q +F EV++ EEF+LL ++ +I DE+ V
Sbjct: 166 DPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNV 225
Query: 191 DSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRD 250
SEE VF AV+ WVK++ +ER LP +LQ+VR+PLL+P+++ + ++P I+ +CRD
Sbjct: 226 RSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRD 285
Query: 251 LVDEAKKFHLRPELRSQMQGPRTRAR--LGANEVLLVVGGFGSQQSPIDVVEKYDPKTQE 308
LVDEAK + L P+ R MQGPRTR R + EVL VGG+ S + I VE+YDP+T E
Sbjct: 286 LVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDA-ISSVERYDPQTNE 344
Query: 309 WSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYS-VAPMNV 367
W + S++++R V L D +Y +GG+DG S L+SVE D ++ W S VAP +
Sbjct: 345 WRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQ---WSSDVAPTST 401
Query: 368 RRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGV 427
R G LG +Y GG DG +ERYDP ++W+ + M T R G + V G
Sbjct: 402 CRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGF 461
Query: 428 IYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHL 487
+Y +GG DG + LN+VE+Y+P W + PM T+R G A+ D IY VGG D T L
Sbjct: 462 LYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTEL 521
Query: 488 SSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSW 547
SS E YN RT+ W+ V +MT+ R VG V+ G+L A+ G+DG + L +IE +DP ++W
Sbjct: 522 SSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTW 581
Query: 548 EVVTSMGTQRCDAGVCVLR 566
+ M +R GV V++
Sbjct: 582 RLYGGMNYRRLGGGVGVIK 600
Score = 158 bits (400), Expect = 1e-38
Identities = 78/191 (40%), Positives = 117/191 (61%), Gaps = 1/191 (0%)
Query: 378 GDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGL 437
G++++ GG+ +S+ERYDP ++W M+ M R G G+ V ++Y +GG+DG
Sbjct: 317 GEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGS 376
Query: 438 NILNSVEKYDPHTGHWTN-VTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIR 496
+ LNSVE+YDP T W++ V P +T R+ GVA+L +Y VGG DG + L+ VE Y+ +
Sbjct: 377 SYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPK 436
Query: 497 TDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQ 556
+ WT V SM+T R V VL G LYA+ G DG S L+++E Y+P + W + MGT+
Sbjct: 437 ENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTR 496
Query: 557 RCDAGVCVLRE 567
R G V ++
Sbjct: 497 RKHLGCAVYQD 507
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 441 bits (1135), Expect = e-124
Identities = 232/561 (41%), Positives = 335/561 (59%), Gaps = 15/561 (2%)
Query: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
H MN LR LCDV + E + AHR+VLAACS YFCAMFT ++SE +
Sbjct: 32 HMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKI 91
Query: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
+I+ + T+ L+D++YT + VT ENVQ LLPAA LLQL V+Q CC+FL+SQL P+N
Sbjct: 92 EIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTN 151
Query: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194
CLGIR FA+ H C DL+Q A ++++HFPEV+ EEF+ LS +V LI D++ V SEE
Sbjct: 152 CLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEE 211
Query: 195 PVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDE 254
VFEAVI+W+ + K+ R E + L+++VR+PLL Y+ ++ E I+ + C+D + E
Sbjct: 212 KVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIE 271
Query: 255 AKKFHLRP-ELRSQMQGPRTRAR--LGANEVLLVVGGFGSQQSP--IDVVEKYDPKTQEW 309
A K+HL P + R ++ PRT+ R + +V++VVGG Q+P I VE YD + W
Sbjct: 272 AMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGG----QAPKAIRSVECYDFEEDRW 327
Query: 310 SFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRR 369
+ + +R V + +Y +GG++G R+ +V+ D D+ W S+A M RR
Sbjct: 328 DQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQ---WTSIASMQERR 384
Query: 370 GLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIY 429
GA L D++Y GGFDGS S+E Y ++W + M T R G+ V G +Y
Sbjct: 385 STLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLY 444
Query: 430 CLGGYDGLN--ILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHL 487
+GGYDG + L++VE+Y+P T W V M+T+RSGAGV +L+ +Y GG DG
Sbjct: 445 AVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVR 504
Query: 488 SSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSW 547
SVE Y+ T++W V M R G + G LY + G DG+ L+S+E Y+P+ D W
Sbjct: 505 KSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKW 564
Query: 548 EVV-TSMGTQRCDAGVCVLRE 567
++ T+M T R AGV V+ +
Sbjct: 565 TLLPTNMSTGRSYAGVAVIHK 585
Score = 100 bits (248), Expect = 5e-21
Identities = 48/129 (37%), Positives = 73/129 (56%)
Query: 440 LNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDS 499
+ SVE YD W + + ++R AGV + H+Y VGGF+G+ + +V+ Y+ D
Sbjct: 314 IRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQ 373
Query: 500 WTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCD 559
WT++ SM R +GA VL LYA+ G+DG++ L+S+E Y + W V M T+R
Sbjct: 374 WTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSS 433
Query: 560 AGVCVLREK 568
GV V+ K
Sbjct: 434 VGVGVVEGK 442
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 437 bits (1125), Expect = e-123
Identities = 242/559 (43%), Positives = 334/559 (59%), Gaps = 15/559 (2%)
Query: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
H K MN LR N LCDVT+ E + AHR+VLAACS YF AMFT E+SE V
Sbjct: 42 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 101
Query: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
I+ + T+ +L+D+VYT + VT ENVQ LLPAA LLQL+ VK+ CCEFLESQL P N
Sbjct: 102 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 161
Query: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194
CLGIR FA+ H C DL+ A ++++HF +VV EEF+ L +V LI D++ + SEE
Sbjct: 162 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 221
Query: 195 PVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDE 254
VFEAVI WV H K R+E + L+++VR+PLL Y+ ++ E ++ S C+D + E
Sbjct: 222 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 281
Query: 255 AKKFHLRP-ELRSQMQGPRTRARLGAN--EVLLVVGGFGSQQSP--IDVVEKYDPKTQEW 309
A K+HL P E R M+ RTR R N ++++VVGG Q+P I VE YD K + W
Sbjct: 282 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG----QAPKAIRSVECYDFKEERW 337
Query: 310 SFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRR 369
+ + +R V + ++ +GG++G R+ +V+ D D+ W SVA M RR
Sbjct: 338 HQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQ---WTSVANMRDRR 394
Query: 370 GLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIY 429
GA L ++Y GGFDGS +S+E Y+ ++W + M T R G+ V G++Y
Sbjct: 395 STLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLY 454
Query: 430 CLGGYDGLN--ILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHL 487
+GGYDG + L++VE Y+ T WT + M+T+RSGAGV +LN+ +Y VGG DG
Sbjct: 455 AVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVR 514
Query: 488 SSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSW 547
SVE Y+ T++W V M R G + G LY + G DG+ L+S+E Y+P D W
Sbjct: 515 KSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKW 574
Query: 548 EVVTS-MGTQRCDAGVCVL 565
VV+S M T R AGV V+
Sbjct: 575 TVVSSCMSTGRSYAGVTVI 593
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 437 bits (1125), Expect = e-123
Identities = 242/559 (43%), Positives = 334/559 (59%), Gaps = 15/559 (2%)
Query: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
H K MN LR N LCDVT+ E + AHR+VLAACS YF AMFT E+SE V
Sbjct: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
Query: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
I+ + T+ +L+D+VYT + VT ENVQ LLPAA LLQL+ VK+ CCEFLESQL P N
Sbjct: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
Query: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194
CLGIR FA+ H C DL+ A ++++HF +VV EEF+ L +V LI D++ + SEE
Sbjct: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
Query: 195 PVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDE 254
VFEAVI WV H K R+E + L+++VR+PLL Y+ ++ E ++ S C+D + E
Sbjct: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
Query: 255 AKKFHLRP-ELRSQMQGPRTRARLGAN--EVLLVVGGFGSQQSP--IDVVEKYDPKTQEW 309
A K+HL P E R M+ RTR R N ++++VVGG Q+P I VE YD K + W
Sbjct: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG----QAPKAIRSVECYDFKEERW 333
Query: 310 SFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRR 369
+ + +R V + ++ +GG++G R+ +V+ D D+ W SVA M RR
Sbjct: 334 HQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQ---WTSVANMRDRR 390
Query: 370 GLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIY 429
GA L ++Y GGFDGS +S+E Y+ ++W + M T R G+ V G++Y
Sbjct: 391 STLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLY 450
Query: 430 CLGGYDGLN--ILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHL 487
+GGYDG + L++VE Y+ T WT + M+T+RSGAGV +LN+ +Y VGG DG
Sbjct: 451 AVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVR 510
Query: 488 SSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSW 547
SVE Y+ T++W V M R G + G LY + G DG+ L+S+E Y+P D W
Sbjct: 511 KSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKW 570
Query: 548 EVVTS-MGTQRCDAGVCVL 565
VV+S M T R AGV V+
Sbjct: 571 TVVSSCMSTGRSYAGVTVI 589
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 429 bits (1103), Expect = e-120
Identities = 230/553 (41%), Positives = 326/553 (58%), Gaps = 6/553 (1%)
Query: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
H +M+ +R+ LCD+ L V K+ AH++VLA+CS YF AMFT+E+SE + +V
Sbjct: 74 HYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHV 133
Query: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
+ + ++ L+ F YT + V NVQ LLPAA LLQL GV+ ACC+FL SQLDPSN
Sbjct: 134 TLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSN 193
Query: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194
CLGIR FA+ H+C DL++AA + +HF +V + EEF+LL +V +L+ D + V SEE
Sbjct: 194 CLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEE 253
Query: 195 PVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDE 254
V+ AV++WVKH R + +P L++ VR+PLL+ ++ +DAE +R C+DL+ E
Sbjct: 254 EVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIE 313
Query: 255 AKKFHLRPELRSQMQGPRTRARL--GANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFL 312
A KFHL PE R + RTR R GA VL VGG GS + E YD +T W +
Sbjct: 314 ALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGG-GSLFAIHGDCEAYDTRTDRWHVV 372
Query: 313 PSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLA 372
S++ +R V ++ +R+Y +GGYDG S L++VE D + W M RR
Sbjct: 373 ASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTN---TWQPEVSMGTRRSCL 429
Query: 373 GATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLG 432
G L ++Y +GG+DG+ S ERYDP W+ + M T R + G +Y +G
Sbjct: 430 GVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVG 489
Query: 433 GYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEA 492
GYD + L +VEKY+P W+ V M ++RS AGVA+L +YV GG DGT+ L+SVE
Sbjct: 490 GYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVER 549
Query: 493 YNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTS 552
Y+ + +W +V M R + G LYA+ G DG+S L+SIE Y+P + W +
Sbjct: 550 YSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASC 609
Query: 553 MGTQRCDAGVCVL 565
M T+R GV VL
Sbjct: 610 MFTRRSSVGVAVL 622
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 424 bits (1091), Expect = e-119
Identities = 224/542 (41%), Positives = 305/542 (56%), Gaps = 5/542 (0%)
Query: 23 MNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTAS 82
M +R+ LCDVTL++ F AHRIVLAA YF AMFT+++ E + + +QG+ S
Sbjct: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
Query: 83 TMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFA 142
+E L++F Y + + +NVQ LL A LQL+ +K ACC FL +L P NCLG+R FA
Sbjct: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
Query: 143 ETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVIN 202
ET C L AA F +HF EV EEF+ L +V +L+ DE+ V SEE VFEA +
Sbjct: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALA 207
Query: 203 WVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLRP 262
WV++ +++R LP LL +R+PL P++++D + + +RC +CRDLVDEAK +HL P
Sbjct: 208 WVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMP 267
Query: 263 ELRSQMQGPRTRARLGAN--EVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRR 320
E R + RTR R + ++ VGG S ++VVE +DP W +T R
Sbjct: 268 ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARS 327
Query: 321 YVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDM 380
V ++ +Y IGGYDG+ RLS+VE + E W V MN +R G L
Sbjct: 328 RVGVAVVNGLLYAIGGYDGQLRLSTVEAYN---PETDTWTRVGSMNSKRSAMGTVVLDGQ 384
Query: 381 IYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNIL 440
IYV GG+DG+ +S+E Y P D+W+++ M + R AG+ V G IY GG+DGL I
Sbjct: 385 IYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIF 444
Query: 441 NSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSW 500
+SVE Y+ HT W M KR G A L ++V GG+DG+ LS E Y+ D W
Sbjct: 445 SSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQW 504
Query: 501 TTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDA 560
+ M T R V GRLYA+ GYDG S LSS+E YDP D W + M
Sbjct: 505 CLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACHEGGV 564
Query: 561 GV 562
GV
Sbjct: 565 GV 566
Score = 155 bits (391), Expect = 1e-37
Identities = 79/195 (40%), Positives = 111/195 (56%), Gaps = 1/195 (0%)
Query: 375 TTLGDMIYVSGGFDGSRRHTSM-ERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGG 433
T++ +IY GG + + ++ E +DP + W M TAR G+ V +G++Y +GG
Sbjct: 284 TSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGG 343
Query: 434 YDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAY 493
YDG L++VE Y+P T WT V M +KRS G +L+ IYV GG+DG + LSSVE Y
Sbjct: 344 YDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETY 403
Query: 494 NIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSM 553
+ TD WT VTSM++ R G TV GR+Y G+DG + SS+E Y+ +W M
Sbjct: 404 SPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGM 463
Query: 554 GTQRCDAGVCVLREK 568
+RC G L K
Sbjct: 464 LNKRCRHGAASLGSK 478
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 415 bits (1067), Expect = e-116
Identities = 213/560 (38%), Positives = 323/560 (57%), Gaps = 13/560 (2%)
Query: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
HA+ M + + LCDV L + PAHR+VL++ SDYF AMFT+++ E + +
Sbjct: 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI 215
Query: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
++G+ +++ L+ + YT + + +N++ LL ACLLQL V +ACC+FL QL PSN
Sbjct: 216 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 275
Query: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194
CLGIR FA+ C DL + A ++ +HF EV++++EF+LL E+ KL+ D++ + +EE
Sbjct: 276 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEE 335
Query: 195 PVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDE 254
+ A++ WV+H ++R + L LL Y+R+PLL P+++ D ++ R ++C+ L+ E
Sbjct: 336 TILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIME 394
Query: 255 AKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPS 314
A K+HL PE R +Q PRT+ R L VGG S + +EKYD +T W+ + +
Sbjct: 395 AMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATS-IEKYDLRTNMWTPVAN 453
Query: 315 ITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGA 374
+ +R L D++YV+GG DG L++VEC + + W + PM+ R G
Sbjct: 454 MNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYN---PKTKTWSVMPPMSTHRHGLGV 510
Query: 375 TTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGY 434
L +Y GG DG ++ER+DP QW+ + M T R G+ V SG +Y +GG
Sbjct: 511 AVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGR 570
Query: 435 DGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDG-----TAHLSS 489
DG + L SVE +DPHT WT M+ +R G GV N +Y +GG D T+ LS
Sbjct: 571 DGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSD 630
Query: 490 -VEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWE 548
VE Y+ +TD WT V SM+ R VG +L +LYA+ GYDG + L+++E YDP + W
Sbjct: 631 CVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWT 690
Query: 549 VVTSMGTQRCDAGVCVLREK 568
V + R AG CV+ K
Sbjct: 691 QVAPLCLGR--AGACVVTVK 708
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 415 bits (1067), Expect = e-116
Identities = 213/560 (38%), Positives = 323/560 (57%), Gaps = 13/560 (2%)
Query: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
HA+ M + + LCDV L + PAHR+VL++ SDYF AMFT+++ E + +
Sbjct: 202 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI 261
Query: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
++G+ +++ L+ + YT + + +N++ LL ACLLQL V +ACC+FL QL PSN
Sbjct: 262 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 321
Query: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194
CLGIR FA+ C DL + A ++ +HF EV++++EF+LL E+ KL+ D++ + +EE
Sbjct: 322 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEE 381
Query: 195 PVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDE 254
+ A++ WV+H ++R + L LL Y+R+PLL P+++ D ++ R ++C+ L+ E
Sbjct: 382 TILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIME 440
Query: 255 AKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPS 314
A K+HL PE R +Q PRT+ R L VGG S + +EKYD +T W+ + +
Sbjct: 441 AMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATS-IEKYDLRTNMWTPVAN 499
Query: 315 ITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGA 374
+ +R L D++YV+GG DG L++VEC + + W + PM+ R G
Sbjct: 500 MNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYN---PKTKTWSVMPPMSTHRHGLGV 556
Query: 375 TTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGY 434
L +Y GG DG ++ER+DP QW+ + M T R G+ V SG +Y +GG
Sbjct: 557 AVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGR 616
Query: 435 DGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDG-----TAHLSS 489
DG + L SVE +DPHT WT M+ +R G GV N +Y +GG D T+ LS
Sbjct: 617 DGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSD 676
Query: 490 -VEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWE 548
VE Y+ +TD WT V SM+ R VG +L +LYA+ GYDG + L+++E YDP + W
Sbjct: 677 CVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWT 736
Query: 549 VVTSMGTQRCDAGVCVLREK 568
V + R AG CV+ K
Sbjct: 737 QVAPLCLGR--AGACVVTVK 754
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 409 bits (1050), Expect = e-114
Identities = 210/551 (38%), Positives = 320/551 (58%), Gaps = 6/551 (1%)
Query: 17 KSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDI 76
K S+ ++ LCDVTL+V K H++VLA YF AMF SE++E + ++I
Sbjct: 51 KDFHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEI 110
Query: 77 QGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCL 136
+ +E L+ FVY+ + +TV+NVQ LL AAC+LQ++ V +ACCE+++ PSNCL
Sbjct: 111 RDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCL 170
Query: 137 GIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPV 196
+R FAE+HN +DLM A+ ++ HF EVV+ E+F+ +S + KL+ ++ +++E+ V
Sbjct: 171 AVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQV 230
Query: 197 FEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAK 256
+ A I W+ + + L L VR+PLL ++ V+ E ++ +L+CRDL+DEA+
Sbjct: 231 YNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEAR 290
Query: 257 KFHLRPELRSQMQ---GPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLP 313
+HL R+ RT R VL VGG G P +E Y W F P
Sbjct: 291 NYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGP 350
Query: 314 SITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAG 373
+ +RR+V +S+ ++Y +GG+DG L S+E D ++ W A MN +R
Sbjct: 351 EMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNK---WMMKASMNTKRRGIA 407
Query: 374 ATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGG 433
+LG IY GG D + +ERYD DQWS + M T R G G V +Y +GG
Sbjct: 408 LASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGG 467
Query: 434 YDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAY 493
DG+ L+SVE+YDPH W V M +R+G GV+ L+ +YVVGGFD + LSSVE Y
Sbjct: 468 NDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERY 527
Query: 494 NIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSM 553
+ R++ W V ++TTPR VG + G+++A+ G++GN+ L+++E +DP+++ WE+V S+
Sbjct: 528 DPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSV 587
Query: 554 GTQRCDAGVCV 564
R AGV V
Sbjct: 588 SHCRAGAGVAV 598
Score = 85.5 bits (210), Expect = 1e-16
Identities = 53/160 (33%), Positives = 81/160 (50%), Gaps = 9/160 (5%)
Query: 271 PRTRARLGANEVLLV-----VGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASV 325
P R G V LV VGG S + VE+YDP +W + + ++R
Sbjct: 445 PMNTPRGGVGSVALVNHVYAVGGNDGMAS-LSSVERYDPHLDKWIEVKEMGQRRAGNGVS 503
Query: 326 SLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSG 385
LH +YV+GG+D S LSSVE D +++ W VA + RG G T+ I+ G
Sbjct: 504 KLHGCLYVVGGFDDNSPLSSVERYDPRSNK---WDYVAALTTPRGGVGIATVMGKIFAVG 560
Query: 386 GFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVAS 425
G +G+ ++E +DP +++W ++G + R GAG+ V S
Sbjct: 561 GHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCS 600
Score = 59.3 bits (142), Expect = 9e-09
Identities = 38/126 (30%), Positives = 67/126 (53%), Gaps = 5/126 (3%)
Query: 259 HLRPELRSQMQGPRTRARLGANEV---LLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSI 315
HL + + G R RA G +++ L VVGGF SP+ VE+YDP++ +W ++ ++
Sbjct: 483 HLDKWIEVKEMGQR-RAGNGVSKLHGCLYVVGGF-DDNSPLSSVERYDPRSNKWDYVAAL 540
Query: 316 TRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGAT 375
T R V ++ +I+ +GG++G + L++VE D + + SV+ G+A +
Sbjct: 541 TTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCS 600
Query: 376 TLGDMI 381
L I
Sbjct: 601 CLTSQI 606
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 408 bits (1049), Expect = e-114
Identities = 212/559 (37%), Positives = 317/559 (56%), Gaps = 11/559 (1%)
Query: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
HA+ M S K LCDV L V + PAHR+VL++ SDYF AMFTS++ E + +
Sbjct: 194 HAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEI 253
Query: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
++G+ + + L+ F YT + + + ++ LL AACLLQL V + CC FL L PSN
Sbjct: 254 KMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSN 313
Query: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194
CLGIR FA+ C++LM+ A ++ ++ EV++++EF+LL E+ KL+ D++ V EE
Sbjct: 314 CLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEE 373
Query: 195 PVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDE 254
+F A++ WVK+ + R L LL ++R+PLL P+ + D ++ + L+C+ L+ E
Sbjct: 374 TIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQKLILE 432
Query: 255 AKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPS 314
A K+HL PE R+ MQ PRT+ R L VGG + + +EKYD +T W
Sbjct: 433 AMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKG-ATTIEKYDLRTNLWIQAGM 491
Query: 315 ITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGA 374
+ +R + D+++VIGG DG L++VEC + + W + PM+ R G
Sbjct: 492 MNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYN---PKTKTWTVLPPMSTHRHGLGV 548
Query: 375 TTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGY 434
T L IY GG DG ++ER+DP QW+ + M AR G+ +G +Y +GG
Sbjct: 549 TVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGR 608
Query: 435 DGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAH------LS 488
DG + L+S+E YDPHT W PM +R G GVA + +Y VGG D A L
Sbjct: 609 DGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLD 668
Query: 489 SVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWE 548
VE Y+ +TD+WT V ++ PR VG +L RLYA+ GYDG + L+++E YDP + W
Sbjct: 669 YVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWT 728
Query: 549 VVTSMGTQRCDAGVCVLRE 567
+ S+ R A V V+++
Sbjct: 729 QMASLNIGRAGACVVVIKQ 747
Score = 114 bits (286), Expect = 2e-25
Identities = 57/143 (39%), Positives = 82/143 (57%)
Query: 426 GVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA 485
G +Y +GG D ++EKYD T W M +R GVA+++D ++V+GG DG
Sbjct: 459 GTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLK 518
Query: 486 HLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIID 545
L++VE YN +T +WT + M+T R +G TVL G +YA+ G+DG S L+++E +DP
Sbjct: 519 TLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQ 578
Query: 546 SWEVVTSMGTQRCDAGVCVLREK 568
W V SM R GV L K
Sbjct: 579 QWTFVASMSIARSTVGVAALNGK 601
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 399 bits (1025), Expect = e-111
Identities = 212/559 (37%), Positives = 314/559 (56%), Gaps = 17/559 (3%)
Query: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
HA+ L M + K LCDV L PAHR+VL+A SDYF AMFT+++ E + V
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
Query: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
++G+ + + L+ + YT + + + ++ LL AACLLQL V C FL QL PSN
Sbjct: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
Query: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194
CLGIR F + C +L+ A ++ +HF EV++++EF+LL E+ KL+ D+I V EE
Sbjct: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
Query: 195 PVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDE 254
+F A++ WV H + R+ L LL Y+R+PLL P+ + D ++ L+C+ L+ E
Sbjct: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLME 402
Query: 255 AKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPS 314
A K+HL PE RS MQ PRT+ R L VGG + + +EKYD +T W + +
Sbjct: 403 AMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKG-TTTIEKYDLRTNSWLHIGT 461
Query: 315 ITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGA 374
+ +R + +++YV+GG DG L++VEC + +W + PM+ R G
Sbjct: 462 MNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGK---IWTVMPPMSTHRHGLGV 518
Query: 375 TTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGY 434
TL +Y GG DG ++ER+DP QW+ + M T R G+V + +Y +GG
Sbjct: 519 ATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGR 578
Query: 435 DGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA--HLS---- 488
DG + L S+E +DPHT W+ PM+ +R G GVA N +YVVGG D A H S
Sbjct: 579 DGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSD 638
Query: 489 SVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSW- 547
VE Y+ + DSW+TV ++ PR V L +LY + GYDG++ L+++E YD + W
Sbjct: 639 CVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 698
Query: 548 -EVVTSMGTQRCDAGVCVL 565
EV ++G AG CV+
Sbjct: 699 EEVPVNIGR----AGACVV 713
Score = 123 bits (308), Expect = 5e-28
Identities = 68/195 (34%), Positives = 103/195 (52%), Gaps = 10/195 (5%)
Query: 283 LLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSR 342
+ VGG S ++ VE++DP+ ++W+++ S++ R V V+L++++Y IGG DG S
Sbjct: 525 MYAVGGHDGW-SYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSC 583
Query: 343 LSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDG------SRRHTSM 396
L S+E D ++ W APM+ RRG G T +YV GG D SR +
Sbjct: 584 LKSMEYFDPHTNK---WSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCV 640
Query: 397 ERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNV 456
ERYDP D WS + + R+ + +Y +GGYDG LN+VE YD W
Sbjct: 641 ERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEE 700
Query: 457 TPMATKRSGAGVALL 471
P+ R+GA V ++
Sbjct: 701 VPVNIGRAGACVVVV 715
Score = 110 bits (274), Expect = 5e-24
Identities = 55/143 (38%), Positives = 81/143 (56%)
Query: 426 GVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA 485
G +Y +GG D + ++EKYD T W ++ M +R GVA++++ +YVVGG DG
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
Query: 486 HLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIID 545
L++VE +N WT + M+T R +G L G +YA+ G+DG S L+++E +DP
Sbjct: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGR 548
Query: 546 SWEVVTSMGTQRCDAGVCVLREK 568
W V SM T R GV L K
Sbjct: 549 QWNYVASMSTPRSTVGVVALNNK 571
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 395 bits (1016), Expect = e-110
Identities = 205/540 (37%), Positives = 305/540 (56%), Gaps = 11/540 (2%)
Query: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
HA+ L M + K LCDV L PAHR+VL+A SDYF AMFT+++ E + V
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
Query: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
++G+ + + L+ + YT + + + ++ LL AACLLQL V C FL QL PSN
Sbjct: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
Query: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194
CLGIR F + C +L+ A ++ +HF EV++++EF+LL E+ KL+ D+I V EE
Sbjct: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
Query: 195 PVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDE 254
+F A++ WV H + R+ L LL Y+R+PLL P+ + D ++ L+C+ L+ E
Sbjct: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLME 402
Query: 255 AKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPS 314
A K+HL PE RS MQ PRT+ R L VGG + + +EKYD +T W + +
Sbjct: 403 AMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKG-TTTIEKYDLRTNSWLHIGT 461
Query: 315 ITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGA 374
+ +R + +++YV+GG DG L++VEC + +W + PM+ R G
Sbjct: 462 MNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGK---IWTVMPPMSTHRHGLGV 518
Query: 375 TTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGY 434
TL +Y GG DG ++ER+DP QW+ + M T R G+V + +Y +GG
Sbjct: 519 ATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGR 578
Query: 435 DGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA--HLS---- 488
DG + L S+E +DPHT W+ PM+ +R G GVA N +YVVGG D A H S
Sbjct: 579 DGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSD 638
Query: 489 SVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWE 548
VE Y+ + DSW+TV ++ PR V L +LY + GYDG++ L+++E YD + W+
Sbjct: 639 CVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 698
Score = 144 bits (362), Expect = 3e-34
Identities = 73/182 (40%), Positives = 103/182 (56%)
Query: 381 IYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNIL 440
+Y GG D + T++E+YD + W +G M R G+ V +Y +GG DGL L
Sbjct: 431 LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTL 490
Query: 441 NSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSW 500
N+VE ++P WT + PM+T R G GVA L +Y VGG DG ++L++VE ++ W
Sbjct: 491 NTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQW 550
Query: 501 TTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDA 560
V SM+TPR VG L +LYAI G DG+S L S+E +DP + W + M +R
Sbjct: 551 NYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGV 610
Query: 561 GV 562
GV
Sbjct: 611 GV 612
Score = 110 bits (274), Expect = 5e-24
Identities = 55/143 (38%), Positives = 81/143 (56%)
Query: 426 GVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA 485
G +Y +GG D + ++EKYD T W ++ M +R GVA++++ +YVVGG DG
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
Query: 486 HLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIID 545
L++VE +N WT + M+T R +G L G +YA+ G+DG S L+++E +DP
Sbjct: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGR 548
Query: 546 SWEVVTSMGTQRCDAGVCVLREK 568
W V SM T R GV L K
Sbjct: 549 QWNYVASMSTPRSTVGVVALNNK 571
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 395 bits (1015), Expect = e-110
Identities = 203/534 (38%), Positives = 311/534 (58%), Gaps = 13/534 (2%)
Query: 41 QKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTV 100
+ D + R+VL++ SDYF AMFT+++ E + + ++G+ +++ L+ + YT + +
Sbjct: 167 ESDSSSCRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKE 226
Query: 101 ENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQK 160
+N++ LL ACLLQL V +ACC+FL QL PSNCLGIR FA+ C DL + A ++ +
Sbjct: 227 DNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTME 286
Query: 161 HFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQ 220
HF EV++++EF+LL E+ KL+ D++ + +EE + A++ WV+H ++R + L LL
Sbjct: 287 HFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLA 346
Query: 221 YVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTRARLGAN 280
Y+R+PLL P+++ D ++ R ++C+ L+ EA K+HL PE R +Q PRT+ R
Sbjct: 347 YIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTV 405
Query: 281 EVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGR 340
L VGG S + +EKYD +T W+ + ++ +R L D++YV+GG DG
Sbjct: 406 GTLFAVGGMDSTKGATS-IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGL 464
Query: 341 SRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYD 400
L++VEC + + W + PM+ R G L +Y GG DG ++ER+D
Sbjct: 465 KTLNTVECYN---PKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWD 521
Query: 401 PNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMA 460
P QW+ + M T R G+ V SG +Y +GG DG + L SVE +DPHT WT M+
Sbjct: 522 PQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMS 581
Query: 461 TKRSGAGVALLNDHIYVVGGFDG-----TAHLSS-VEAYNIRTDSWTTVTSMTTPRCYVG 514
+R G GV N +Y +GG D T+ LS VE Y+ +TD WT V SM+ R VG
Sbjct: 582 KRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG 641
Query: 515 ATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLREK 568
+L +LYA+ GYDG + L+++E YDP + W V + R AG CV+ K
Sbjct: 642 VCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGR--AGACVVTVK 693
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 384 bits (986), Expect = e-106
Identities = 215/563 (38%), Positives = 314/563 (55%), Gaps = 12/563 (2%)
Query: 11 MTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKG 70
+T+ H++ +L +N LR+ + LCD+ LRV AH++VLA+ S YF AMFT LSEK
Sbjct: 13 LTHLHSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKE 72
Query: 71 KPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQL 130
V+ Q + + ++ ++++ YT TV ++ + V+ LLPAA LLQ+K V + CC FLESQL
Sbjct: 73 NSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQL 132
Query: 131 DPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQV 190
DP NC+GI FAET+ C DL AA + ++F V Q EEF L+ ++++++ D + V
Sbjct: 133 DPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNV 192
Query: 191 DSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRD 250
+EE VF A+ +W+K+ +ER++ L LL VR+PLL+ +++T + +A IR C+
Sbjct: 193 ATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKH 252
Query: 251 LVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWS 310
L++EA K+H PE R Q A +VL VGG + +D VE Y P+ W
Sbjct: 253 LLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWI 312
Query: 311 FLPSITRKRRYVASVSLHDRIYVIGGYDG--------RSRLSSVECLDYTADEDGVWYSV 362
L + R L ++YVIGG R +SVEC + + W S+
Sbjct: 313 GLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWN---PDTNTWTSL 369
Query: 363 APMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLV 422
MN R G L +Y GG+DG S+E+Y P I +W + M T R
Sbjct: 370 ERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAA 429
Query: 423 VASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFD 482
V G+IY +GGY G +NSVE+YDP W V MA KR GV ++ I+VVGG +
Sbjct: 430 VLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHN 488
Query: 483 GTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDP 542
G +HLSS+E Y+ + WT M PR VGA V+ LY + G+ G+S L++++ YDP
Sbjct: 489 GVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDP 548
Query: 543 IIDSWEVVTSMGTQRCDAGVCVL 565
I D+W M RC+ G+ L
Sbjct: 549 ISDTWLDSAGMIYCRCNFGLTAL 571
Score = 35.4 bits (80), Expect = 0.14
Identities = 23/64 (35%), Positives = 31/64 (48%), Gaps = 7/64 (10%)
Query: 506 MTTPRCYVGATVLRGRLYAIAGYDGN-SLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCV 564
MT PRC L A+ G G + L S+E Y P DSW + + R + G+CV
Sbjct: 275 MTRPRCAPKV------LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICV 328
Query: 565 LREK 568
L +K
Sbjct: 329 LDQK 332
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 380 bits (976), Expect = e-105
Identities = 213/508 (41%), Positives = 302/508 (59%), Gaps = 15/508 (2%)
Query: 66 LSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEF 125
+SE V I+ + T+ +L+D+VYT + VT ENVQ LLPAA LLQL+ VK+ CCEF
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 126 LESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKC 185
LESQL P NCLGIR FA+ H C DL+ A ++++HF +VV EEF+ L +V LI
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 186 DEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCS 245
D++ + SEE VFEAVI WV H K R+E + L+++VR+PLL Y+ ++ E ++ S
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
Query: 246 LQCRDLVDEAKKFHLRP-ELRSQMQGPRTRARLGAN--EVLLVVGGFGSQQSP--IDVVE 300
C+D + EA K+HL P E R M+ RTR R N ++++VVGG Q+P I VE
Sbjct: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG----QAPKAIRSVE 236
Query: 301 KYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWY 360
YD K + W + + +R V + ++ +GG++G R+ +V+ D D+ W
Sbjct: 237 CYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQ---WT 293
Query: 361 SVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAG 420
SVA M RR GA L ++Y GGFDGS +S+E Y+ ++W + M T R G
Sbjct: 294 SVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVG 353
Query: 421 LVVASGVIYCLGGYDGLN--ILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVV 478
+ V G++Y +GGYDG + L++VE Y+ T WT + M+T+RSGAGV +LN+ +Y V
Sbjct: 354 VGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAV 413
Query: 479 GGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIE 538
GG DG SVE Y+ T++W V M R G + G LY + G DG+ L+S+E
Sbjct: 414 GGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVE 473
Query: 539 CYDPIIDSWEVVTS-MGTQRCDAGVCVL 565
Y+P D W VV+S M T R AGV V+
Sbjct: 474 YYNPTTDKWTVVSSCMSTGRSYAGVTVI 501
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 365 bits (938), Expect = e-101
Identities = 209/562 (37%), Positives = 306/562 (54%), Gaps = 18/562 (3%)
Query: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPA-----HRIVLAACSDYFCAMFTSELSEK 69
H K MN LR S LCDVTL+V+ +D PA H++VLA+ S F AMFT+ L E+
Sbjct: 59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
Query: 70 GKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQ 129
G V I+G+ ME L++F YT ++ + + V ++ A + Q+ V +AC +FL Q
Sbjct: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
Query: 130 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQ 189
LDPSN +GI +FAE CV+L Q A + HF EV + EEF LS ++ LI D++
Sbjct: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
Query: 190 VDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCR 249
V E VF A INWVK+ ++R + LL+ VR LTP ++ + ++ +C+
Sbjct: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
Query: 250 DLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEW 309
D + K F + P ++G ++ GG+ Q + +E Y+P W
Sbjct: 299 DYL--VKIFEELTLHKPTQVMPCRAPKVG--RLIYTAGGYFRQS--LSYLEAYNPSDGTW 352
Query: 310 SFLPSITRKRRYVASVSLHDRIYVIGGY----DGRSRLSSVECLDYTADEDGVWYSVAPM 365
L + R +A + +Y +GG DG + S+++C + ++ W APM
Sbjct: 353 LRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQ---WSPCAPM 409
Query: 366 NVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVAS 425
+V R G + IY GG G H S+ERY+P D+W ++ M T R G G+ V +
Sbjct: 410 SVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLN 469
Query: 426 GVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA 485
++Y +GG+DG N LNS E Y P W +T M T RSGAGV +L++ IY GG+DG
Sbjct: 470 RLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQD 529
Query: 486 HLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIID 545
L+SVE Y++ T++WT V M R +G TV +GR+Y + GYDG++ L S+ECYDP D
Sbjct: 530 QLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589
Query: 546 SWEVVTSMGTQRCDAGVCVLRE 567
+W VT M + R GV V E
Sbjct: 590 TWSEVTRMTSGRSGVGVAVTME 611
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 365 bits (938), Expect = e-101
Identities = 209/562 (37%), Positives = 306/562 (54%), Gaps = 18/562 (3%)
Query: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPA-----HRIVLAACSDYFCAMFTSELSEK 69
H K MN LR S LCDVTL+V+ +D PA H++VLA+ S F AMFT+ L E+
Sbjct: 59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
Query: 70 GKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQ 129
G V I+G+ ME L++F YT ++ + + V ++ A + Q+ V +AC +FL Q
Sbjct: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
Query: 130 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQ 189
LDPSN +GI +FAE CV+L Q A + HF EV + EEF LS ++ LI D++
Sbjct: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
Query: 190 VDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCR 249
V E VF A INWVK+ ++R + LL+ VR LTP ++ + ++ +C+
Sbjct: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
Query: 250 DLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEW 309
D + K F + P ++G ++ GG+ Q + +E Y+P W
Sbjct: 299 DYL--VKIFEELTLHKPTQVMPCRAPKVG--RLIYTAGGYFRQS--LSYLEAYNPSDGTW 352
Query: 310 SFLPSITRKRRYVASVSLHDRIYVIGGY----DGRSRLSSVECLDYTADEDGVWYSVAPM 365
L + R +A + +Y +GG DG + S+++C + ++ W APM
Sbjct: 353 LRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQ---WSPCAPM 409
Query: 366 NVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVAS 425
+V R G + IY GG G H S+ERY+P D+W ++ M T R G G+ V +
Sbjct: 410 SVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLN 469
Query: 426 GVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA 485
++Y +GG+DG N LNS E Y P W +T M T RSGAGV +L++ IY GG+DG
Sbjct: 470 RLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQD 529
Query: 486 HLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIID 545
L+SVE Y++ T++WT V M R +G TV +GR+Y + GYDG++ L S+ECYDP D
Sbjct: 530 QLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589
Query: 546 SWEVVTSMGTQRCDAGVCVLRE 567
+W VT M + R GV V E
Sbjct: 590 TWSEVTRMTSGRSGVGVAVTME 611
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 350 bits (899), Expect = 2e-96
Identities = 187/548 (34%), Positives = 295/548 (53%), Gaps = 11/548 (2%)
Query: 24 NSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTAST 83
N LR LCDV ++V +F AH+ +L +CS YF A+FTS + K +I G++
Sbjct: 30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDM 89
Query: 84 MEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAE 143
M++++++ YT TV +T +NV++LL AA + G+ + CCEFL+S+L NC+GI F +
Sbjct: 90 MKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTD 149
Query: 144 THNCVDLMQAAEVFSQKHFPEVVQ-HEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVIN 202
+ C +L Q A +F +F E+V+ EF+ LS E++ +I+ DE+ V E+ VFEA++
Sbjct: 150 YYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILK 209
Query: 203 WVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKK----F 258
W+ H + R++ + LL VR+ L+ Y + + +++ S +C+ ++ A K
Sbjct: 210 WISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDL 269
Query: 259 HLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRK 318
++ S P TR RL +L +GG+ S SP + +E YD + W +
Sbjct: 270 NMNGPSNSDFTNPLTRPRL-PYAILFAIGGW-SGGSPTNAIEAYDARADRWVNVTCEEES 327
Query: 319 -RRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTL 377
R Y + L +Y+IGG+D +SV+ D W+ VAPM+ RR T L
Sbjct: 328 PRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKK---TWHQVAPMHSRRCYVSVTVL 384
Query: 378 GDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGL 437
G+ IY GGFDG R + ERY+P +QW+++ M R A G +Y GG++G
Sbjct: 385 GNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGN 444
Query: 438 NILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRT 497
L + E Y+ + WT + PM ++RSG GV +H+Y VGGFDG L S EAY+
Sbjct: 445 ECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVA 504
Query: 498 DSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQR 557
++W T+ +M PR G V+ L+ + G++G + ++ECYD D W M R
Sbjct: 505 NTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYR 564
Query: 558 CDAGVCVL 565
CV+
Sbjct: 565 SALSCCVV 572
Score = 124 bits (310), Expect = 3e-28
Identities = 60/189 (31%), Positives = 99/189 (52%), Gaps = 1/189 (0%)
Query: 380 MIYVSGGFDGSRRHTSMERYDPNIDQW-SMLGDMQTAREGAGLVVASGVIYCLGGYDGLN 438
+++ GG+ G ++E YD D+W ++ + ++ R G G +Y +GG+D ++
Sbjct: 292 ILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVD 351
Query: 439 ILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTD 498
NSV+++DP W V PM ++R V +L + IY +GGFDG L++ E Y T+
Sbjct: 352 YFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETN 411
Query: 499 SWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRC 558
WT + M R AT L G++Y G++GN L + E Y+ + W V+ M ++R
Sbjct: 412 QWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRS 471
Query: 559 DAGVCVLRE 567
GV E
Sbjct: 472 GIGVIAYGE 480
Score = 101 bits (252), Expect = 2e-21
Identities = 49/143 (34%), Positives = 79/143 (55%), Gaps = 1/143 (0%)
Query: 427 VIYCLGGYDGLNILNSVEKYDPHTGHWTNVT-PMATKRSGAGVALLNDHIYVVGGFDGTA 485
+++ +GG+ G + N++E YD W NVT + R+ G A L ++Y++GGFD
Sbjct: 292 ILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVD 351
Query: 486 HLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIID 545
+ +SV+ ++ +W V M + RCYV TVL +YA+ G+DG L++ E Y+P +
Sbjct: 352 YFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETN 411
Query: 546 SWEVVTSMGTQRCDAGVCVLREK 568
W ++ M QR DA L K
Sbjct: 412 QWTLIAPMHEQRSDASATTLYGK 434
Score = 71.2 bits (173), Expect = 2e-12
Identities = 37/143 (25%), Positives = 68/143 (47%), Gaps = 4/143 (2%)
Query: 285 VVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLS 344
+ GGF + + E Y+ ++ +W+ + + +R + ++ + +Y +GG+DG +RL
Sbjct: 437 ICGGFNGNEC-LFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLR 495
Query: 345 SVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNID 404
S E A+ W ++ M R G + D+++V GGF+G ++E YD D
Sbjct: 496 SAEAYSPVAN---TWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTD 552
Query: 405 QWSMLGDMQTAREGAGLVVASGV 427
+W DM R V G+
Sbjct: 553 EWYDAHDMSIYRSALSCCVVPGL 575
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 337 bits (863), Expect = 2e-92
Identities = 201/578 (34%), Positives = 302/578 (52%), Gaps = 21/578 (3%)
Query: 6 APKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSE 65
A ++ HA+ IL +N +R CDV L+V Q+ F AHR+VLAA S YF A+FT
Sbjct: 10 ADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGG 69
Query: 66 LSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEF 125
+ E K V I G+ A +ILLDF+YT V++ V NVQEL+ AA +LQL V CCEF
Sbjct: 70 MKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEF 129
Query: 126 LESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKC 185
L+ Q+DP NC+GI F+E C DL++ +E + HF EV EEF+ L++ ++ K+++
Sbjct: 130 LKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRS 189
Query: 186 DEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCS 245
+E+ ++ E VF A + W+ +R + + +L +R PLL P+ + I+
Sbjct: 190 EELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLR 249
Query: 246 LQCRDLVDEAKKFHLRP---ELRSQMQGPRTRARLGANEVLLVVGGF-------GSQQSP 295
+ + L+ E + P + S +Q + R R A + L VGG+ S
Sbjct: 250 VALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRA 309
Query: 296 IDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADE 355
+ VE++D +Q W+ + S+ + R + L +Y IGG EC D +
Sbjct: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQ 369
Query: 356 DGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTA 415
W +VA MN R G IY GG+ G+ ++ER+DP+ ++W ++G+M +
Sbjct: 370 ---WTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVS 426
Query: 416 REGAGLVVASGVIYCLGGYDGLNI-LNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDH 474
R G G+IY +GG I L S E YDP + W+ + PM T+R+ GVA LND
Sbjct: 427 RYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDC 486
Query: 475 IYVVGGFDGTAH-LSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGN-- 531
IY VGG++ T L +VE Y+ + W V SM PR + + G LY G +
Sbjct: 487 IYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHD 546
Query: 532 ----SLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVL 565
L S+E Y+P D+W + +M T RC+ GV VL
Sbjct: 547 FLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
Score = 114 bits (284), Expect = 3e-25
Identities = 60/184 (32%), Positives = 90/184 (48%), Gaps = 1/184 (0%)
Query: 385 GGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVE 444
G + SR + +ER+D W+ + + AR G G+ V G++Y +GG I + E
Sbjct: 302 GRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTE 361
Query: 445 KYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVT 504
YDP T WT V M R G GV + IY +GG+ G +++E ++ + W V
Sbjct: 362 CYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVG 421
Query: 505 SMTTPRCYVGATVLRGRLYAIAGYDGNSL-LSSIECYDPIIDSWEVVTSMGTQRCDAGVC 563
+M R Y G ++G +Y I G + L S E YDP+ W + MGT+R GV
Sbjct: 422 NMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVA 481
Query: 564 VLRE 567
L +
Sbjct: 482 ALND 485
Score = 100 bits (248), Expect = 5e-21
Identities = 52/147 (35%), Positives = 78/147 (53%), Gaps = 8/147 (5%)
Query: 428 IYCLGGYDGLN--------ILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVG 479
+Y +GGY L L+ VE++D + +WT V+ + RSG GV +L +Y +G
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
Query: 480 GFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIEC 539
G + E Y+ T WTTV SM PRC +G V G +YA+ G+ G + ++IE
Sbjct: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
Query: 540 YDPIIDSWEVVTSMGTQRCDAGVCVLR 566
+DP + WEVV +M R G C ++
Sbjct: 410 FDPDENKWEVVGNMAVSRYYFGCCEMQ 436
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 312 bits (800), Expect = 5e-85
Identities = 186/534 (34%), Positives = 280/534 (52%), Gaps = 15/534 (2%)
Query: 6 APKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSE 65
A ++ HA+ IL +N +R CDV L+V Q+ F AHR+VLAA S YF A+FT
Sbjct: 10 ADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGG 69
Query: 66 LSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEF 125
+ E K V I G+ A +ILLDF+YT V++ V NVQEL+ AA +LQL V CCEF
Sbjct: 70 MKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEF 129
Query: 126 LESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKC 185
L+ Q+DP NC+GI F+E C DL++ +E + HF EV EEF+ L++ ++ K+++
Sbjct: 130 LKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRS 189
Query: 186 DEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCS 245
+E+ ++ E VF A + W+ +R + + +L +R PLL P+ + I+
Sbjct: 190 EELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLR 249
Query: 246 LQCRDLVDEAKKFHLRP---ELRSQMQGPRTRARLGANEVLLVVGGF-------GSQQSP 295
+ + L+ E + P + S +Q + R R A + L VGG+ S
Sbjct: 250 VALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRA 309
Query: 296 IDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADE 355
+ VE++D +Q W+ + S+ + R + L +Y IGG EC D +
Sbjct: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQ 369
Query: 356 DGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTA 415
W +VA MN R G IY GG+ G+ ++ER+DP+ ++W ++G+M +
Sbjct: 370 ---WTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVS 426
Query: 416 REGAGLVVASGVIYCLGGYDGLNI-LNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDH 474
R G G+IY +GG I L S E YDP + W+ + PM T+R+ GVA LND
Sbjct: 427 RYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDC 486
Query: 475 IYVVGGFDGTAH-LSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAG 527
IY VGG++ T L +VE Y+ + W V SM PR + + G LY G
Sbjct: 487 IYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
Score = 114 bits (284), Expect = 3e-25
Identities = 60/184 (32%), Positives = 90/184 (48%), Gaps = 1/184 (0%)
Query: 385 GGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVE 444
G + SR + +ER+D W+ + + AR G G+ V G++Y +GG I + E
Sbjct: 302 GRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTE 361
Query: 445 KYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVT 504
YDP T WT V M R G GV + IY +GG+ G +++E ++ + W V
Sbjct: 362 CYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVG 421
Query: 505 SMTTPRCYVGATVLRGRLYAIAGYDGNSL-LSSIECYDPIIDSWEVVTSMGTQRCDAGVC 563
+M R Y G ++G +Y I G + L S E YDP+ W + MGT+R GV
Sbjct: 422 NMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVA 481
Query: 564 VLRE 567
L +
Sbjct: 482 ALND 485
Score = 100 bits (248), Expect = 5e-21
Identities = 52/147 (35%), Positives = 78/147 (53%), Gaps = 8/147 (5%)
Query: 428 IYCLGGYDGLN--------ILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVG 479
+Y +GGY L L+ VE++D + +WT V+ + RSG GV +L +Y +G
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
Query: 480 GFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIEC 539
G + E Y+ T WTTV SM PRC +G V G +YA+ G+ G + ++IE
Sbjct: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
Query: 540 YDPIIDSWEVVTSMGTQRCDAGVCVLR 566
+DP + WEVV +M R G C ++
Sbjct: 410 FDPDENKWEVVGNMAVSRYYFGCCEMQ 436
Score = 61.2 bits (147), Expect = 2e-09
Identities = 35/110 (31%), Positives = 58/110 (52%), Gaps = 4/110 (3%)
Query: 282 VLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGY-DGR 340
++ V+GG ++ + E YDP ++ WS LP + +R Y+ +L+D IY +GG+ + +
Sbjct: 438 LIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ 497
Query: 341 SRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGS 390
L +VE + E+ W VA M V R + ++YVSGG S
Sbjct: 498 DALHTVEKYSF---EEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 302 bits (773), Expect = 6e-82
Identities = 191/540 (35%), Positives = 282/540 (52%), Gaps = 28/540 (5%)
Query: 13 NTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKP 72
++HA++IL N R S DV + VE K+FP HR VL+ACS YF AMF ++ E +
Sbjct: 46 SSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREM 105
Query: 73 YVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDP 132
V+I G+ A ME L +VYT V +T ENVQ L + L Q+ ++ AC +FLE QLDP
Sbjct: 106 LVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDP 165
Query: 133 SNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDS 192
NCLGI+ FA+TH+ L + F+ + F +V QHEEF+ L + E+ I DE+ +
Sbjct: 166 CNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGK 225
Query: 193 EEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLV 252
EE VFEAV+ WV A R L LL +VR+PLL P Y ++ + I+ S +C L+
Sbjct: 226 EEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLL 285
Query: 253 DEAKKFHLRPELRSQMQGPRTRAR--LGANEVLLVVGG---FGSQQSPIDVVEKYDPKTQ 307
EA+++H+ L ++M PRTR R G +EV++VVGG G P E YDP T
Sbjct: 286 HEARRYHI---LGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLP--YTECYDPVTG 340
Query: 308 EW---SFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAP 364
EW + LP T+ A +L + I V GG R++S + Y + + +W VA
Sbjct: 341 EWKSLAKLPEFTKSE--YAVCALRNDILVSGG-----RINSRDVWIYNS-QLNIWIRVAS 392
Query: 365 MNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVA 424
+N R L +YV GG+DG R +S+E YD ++W+ + ++ A +
Sbjct: 393 LNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSC 452
Query: 425 SGVIYCL-GGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDG 483
G ++ + GG D + V+ YDP T W + + LN+ IYV GG
Sbjct: 453 VGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGL-- 510
Query: 484 TAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAG-YDGNSLLSSIECYDP 542
++ Y+ D W V + + + G +V G++Y + G + +I CYDP
Sbjct: 511 ---TKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDP 567
Score = 70.9 bits (172), Expect = 3e-12
Identities = 49/133 (36%), Positives = 65/133 (48%), Gaps = 8/133 (6%)
Query: 425 SGVIYCLGGYDGLNILNS--VEKYDPHTGHWTNVT--PMATKRSGAGVALLNDHIYVVGG 480
S VI +GG + + N E YDP TG W ++ P TK A AL ND I V GG
Sbjct: 312 SEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRND-ILVSGG 370
Query: 481 FDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECY 540
+ V YN + + W V S+ R VL G++Y + GYDG + LSS+ECY
Sbjct: 371 ---RINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECY 427
Query: 541 DPIIDSWEVVTSM 553
D + W V +
Sbjct: 428 DSFSNRWTEVAPL 440
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 293 bits (751), Expect = 2e-79
Identities = 183/533 (34%), Positives = 280/533 (52%), Gaps = 19/533 (3%)
Query: 23 MNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTAS 82
MN++RK TLCDV L V+++ PAHR+VLAA S +F MFT+ + E V+++
Sbjct: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93
Query: 83 TMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFA 142
+E L++F YT + V NVQ LL AA Q++ VK+ C +FL+ Q+D SNCLGI A
Sbjct: 94 IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153
Query: 143 ETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVIN 202
E +C +L A+ F +HF EV + +EF+ L V L+ D + V +E+ V++A +
Sbjct: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213
Query: 203 WVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFH-LR 261
W+K+ + R+ + ++L VR PL++ +++ + AEP I+ + +C +V ++H L
Sbjct: 214 WLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLS 273
Query: 262 PELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRY 321
PE R ++ TR R ++ + + G QS ++PK W+ + KRR
Sbjct: 274 PEDREELV-DGTRPRRKKHDYRIALFGGSQPQS----CRYFNPKDYSWTDIRCPFEKRRD 328
Query: 322 VASVSLHDRIYVIGGYDGRSRLSSVECLD-YTADEDGVWYS-VAPMNVRRGLAGATTLGD 379
A V + +Y++GG S+L ++ +D Y +D WYS + P R LA G
Sbjct: 329 AACVFWDNVVYILGG----SQLFPIKRMDCYNVVKDS-WYSKLGPPTPRDSLAACAAEG- 382
Query: 380 MIYVSGGFD-GSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLN 438
IY SGG + G+ E YD + W M T R G+V A+G+IY GG G N
Sbjct: 383 KIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNN 442
Query: 439 ----ILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYN 494
+LNS E YDP T WT + PM R G+ + D I+ VGG +G L +VE Y+
Sbjct: 443 VSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYD 502
Query: 495 IRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSW 547
I+ + W V+ M V + +Y +AG+ G L I Y+ D W
Sbjct: 503 IKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555
Score = 72.4 bits (176), Expect = 1e-12
Identities = 52/185 (28%), Positives = 79/185 (42%), Gaps = 6/185 (3%)
Query: 389 GSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDP 448
G + S ++P W+ + R A V V+Y LGG L + ++ Y+
Sbjct: 299 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFPIKRMDCYNV 357
Query: 449 HTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFD-GTAHLSSVEAYNIRTDSWTTVTSMT 507
W + T R IY GG + G + L E Y+ RT+SW T SM
Sbjct: 358 VKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSML 417
Query: 508 TPRCYVGATVLRGRLYAIAGYDGNSL----LSSIECYDPIIDSWEVVTSMGTQRCDAGVC 563
T RC G G +Y G GN++ L+S E YDP ++W + M R + G+
Sbjct: 418 TQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLV 477
Query: 564 VLREK 568
+++K
Sbjct: 478 FVKDK 482
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 288 bits (737), Expect = 9e-78
Identities = 184/546 (33%), Positives = 285/546 (52%), Gaps = 21/546 (3%)
Query: 10 IMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEK 69
++ T ++ L S +L+K TLCDV L V+++ PAHR+VLAA S +F MFT+ + E
Sbjct: 1 MLGGTDCRTFLTSHINLKK--TLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLES 58
Query: 70 GKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQ 129
V+++ +E L++F YT + V NVQ LL AA Q++ VK+ C +FL+ Q
Sbjct: 59 KSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQ 118
Query: 130 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQ 189
+D SNCLGI AE +C +L A+ F +HF EV + +EF+ L V L+ D +
Sbjct: 119 VDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLT 178
Query: 190 VDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCR 249
V +E+ V++A + W+K+ + R+ + ++L VR PL++ +++ + AEP I+ + +C
Sbjct: 179 VRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECL 238
Query: 250 DLVDEAKKFH-LRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQE 308
+V ++H L PE R ++ TR R ++ + + G QS ++PK
Sbjct: 239 KMVISGMRYHLLSPEDREELV-DGTRPRRKKHDYRIALFGGSQPQS----CRYFNPKDYS 293
Query: 309 WSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLD-YTADEDGVWYS-VAPMN 366
W+ + KRR A V + +Y++GG S+L ++ +D Y +D WYS + P
Sbjct: 294 WTDIRCPFEKRRDAACVFWDNVVYILGG----SQLFPIKRMDCYNVVKDS-WYSKLGPPT 348
Query: 367 VRRGLAGATTLGDMIYVSGGFD-GSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVAS 425
R LA G IY SGG + G+ E YD + W M T R G+V A+
Sbjct: 349 PRDSLAACAAEG-KIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEAN 407
Query: 426 GVIYCLGGYDGLN----ILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGF 481
G+IY GG G N +LNS E YDP T WT + PM R G+ + D I+ VGG
Sbjct: 408 GLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQ 467
Query: 482 DGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYD 541
+G L +VE Y+I+ + W V+ M V + +Y +AG+ G L I Y+
Sbjct: 468 NGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYN 527
Query: 542 PIIDSW 547
D W
Sbjct: 528 TETDKW 533
Score = 72.4 bits (176), Expect = 1e-12
Identities = 52/185 (28%), Positives = 79/185 (42%), Gaps = 6/185 (3%)
Query: 389 GSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDP 448
G + S ++P W+ + R A V V+Y LGG L + ++ Y+
Sbjct: 277 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFPIKRMDCYNV 335
Query: 449 HTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFD-GTAHLSSVEAYNIRTDSWTTVTSMT 507
W + T R IY GG + G + L E Y+ RT+SW T SM
Sbjct: 336 VKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSML 395
Query: 508 TPRCYVGATVLRGRLYAIAGYDGNSL----LSSIECYDPIIDSWEVVTSMGTQRCDAGVC 563
T RC G G +Y G GN++ L+S E YDP ++W + M R + G+
Sbjct: 396 TQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLV 455
Query: 564 VLREK 568
+++K
Sbjct: 456 FVKDK 460
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 274 bits (701), Expect = 1e-73
Identities = 173/553 (31%), Positives = 268/553 (48%), Gaps = 21/553 (3%)
Query: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKG---- 70
H + +L +N R++ D+ + VE ++F H+ VLA+CS YF + + + G
Sbjct: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
Query: 71 -KPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQ 129
K + + L A +E+LL+FVYT ++ + N + LL AA Q + C FLE Q
Sbjct: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
Query: 130 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQ 189
L SNCLG+ AE C +L A+ F+ + FPEV EE + +S+ + + D +
Sbjct: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
Query: 190 VDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCR 249
+EE V+E VI W+K R + LL VR+P + P Y+ +V+D E I+ S CR
Sbjct: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
Query: 250 DLVDEAKKFHLRPELRSQMQGPRTRARL--GANEVLLVVGG---FGSQQSPIDVVEKYDP 304
DLV+EAK++H+ P R +MQ PRTR RL G EV+++VGG G Q + V ++P
Sbjct: 551 DLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNP 610
Query: 305 KTQEWSFLPSIT-RKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVA 363
+ +W L S+ R + + VS D IY+ GG + L+ V C D W V+
Sbjct: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDN---WNLVS 667
Query: 364 PMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVV 423
M V R + IY GG + +ERYD +QW + + A A V
Sbjct: 668 RMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATV 727
Query: 424 ASGVIYCLGGYDGLNILNSV-EKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFD 482
G IY GG + V + Y P T W+ + A LN ++++GG
Sbjct: 728 CGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG-- 785
Query: 483 GTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNS--LLSSIECY 540
A+ + Y+ + +M R + A VL G++YA G + L ++E Y
Sbjct: 786 --AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAY 843
Query: 541 DPIIDSWEVVTSM 553
+P ++W ++ M
Sbjct: 844 EPTTNTWTLLPHM 856
Score = 41.2 bits (95), Expect = 0.003
Identities = 32/128 (25%), Positives = 55/128 (42%), Gaps = 11/128 (8%)
Query: 438 NILNSVEKYD--PHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA----HLSSVE 491
+++N ++Y PH TP R AGVA + I +VGG L +V
Sbjct: 551 DLVNEAKRYHMLPHARQEMQ-TPRTRPRLSAGVA---EVIVLVGGRQMVGMTQRSLVAVT 606
Query: 492 AYNIRTDSWTTVTSMTT-PRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVV 550
+N + + W + S+ R + +Y G + L+ + CY ++D+W +V
Sbjct: 607 CWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLV 666
Query: 551 TSMGTQRC 558
+ M RC
Sbjct: 667 SRMTVPRC 674
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 274 bits (701), Expect = 1e-73
Identities = 173/553 (31%), Positives = 268/553 (48%), Gaps = 21/553 (3%)
Query: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKG---- 70
H + +L +N R++ D+ + VE ++F H+ VLA+CS YF + + + G
Sbjct: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
Query: 71 -KPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQ 129
K + + L A +E+LL+FVYT ++ + N + LL AA Q + C FLE Q
Sbjct: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
Query: 130 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQ 189
L SNCLG+ AE C +L A+ F+ + FPEV EE + +S+ + + D +
Sbjct: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
Query: 190 VDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCR 249
+EE V+E VI W+K R + LL VR+P + P Y+ +V+D E I+ S CR
Sbjct: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
Query: 250 DLVDEAKKFHLRPELRSQMQGPRTRARL--GANEVLLVVGG---FGSQQSPIDVVEKYDP 304
DLV+EAK++H+ P R +MQ PRTR RL G EV+++VGG G Q + V ++P
Sbjct: 551 DLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNP 610
Query: 305 KTQEWSFLPSIT-RKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVA 363
+ +W L S+ R + + VS D IY+ GG + L+ V C D W V+
Sbjct: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDN---WNLVS 667
Query: 364 PMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVV 423
M V R + IY GG + +ERYD +QW + + A A V
Sbjct: 668 RMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATV 727
Query: 424 ASGVIYCLGGYDGLNILNSV-EKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFD 482
G IY GG + V + Y P T W+ + A LN ++++GG
Sbjct: 728 CGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG-- 785
Query: 483 GTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNS--LLSSIECY 540
A+ + Y+ + +M R + A VL G++YA G + L ++E Y
Sbjct: 786 --AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAY 843
Query: 541 DPIIDSWEVVTSM 553
+P ++W ++ M
Sbjct: 844 EPTTNTWTLLPHM 856
Score = 41.2 bits (95), Expect = 0.003
Identities = 32/128 (25%), Positives = 55/128 (42%), Gaps = 11/128 (8%)
Query: 438 NILNSVEKYD--PHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA----HLSSVE 491
+++N ++Y PH TP R AGVA + I +VGG L +V
Sbjct: 551 DLVNEAKRYHMLPHARQEMQ-TPRTRPRLSAGVA---EVIVLVGGRQMVGMTQRSLVAVT 606
Query: 492 AYNIRTDSWTTVTSMTT-PRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVV 550
+N + + W + S+ R + +Y G + L+ + CY ++D+W +V
Sbjct: 607 CWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLV 666
Query: 551 TSMGTQRC 558
+ M RC
Sbjct: 667 SRMTVPRC 674
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 268 bits (685), Expect = 1e-71
Identities = 171/536 (31%), Positives = 272/536 (50%), Gaps = 28/536 (5%)
Query: 21 NSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLT 80
N + +LR N L DV L V+ ++F HR+VLAA S+YF AMF ++L EK + + I+G+
Sbjct: 60 NGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVD 119
Query: 81 ASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRD 140
A TM LLD+ YT +T +NVQ +L AA L Q + AC FL L+P NC+GI
Sbjct: 120 AETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILR 179
Query: 141 FAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAV 200
A+TH+ L + + + ++F +++ EEF+ L + ++K D++ V E VFE V
Sbjct: 180 LADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETV 239
Query: 201 INWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHL 260
++WV+H ER LP +L+ VR+PLL P Y + ++A+P IR + L+ EA+ +HL
Sbjct: 240 MSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHL 299
Query: 261 RPELRSQMQGPRTRARLG--ANEVLLVVGGFGSQQSPIDVVEKYDPKTQ---EWSFLP-- 313
+++ RT+ R+ +EV +++GG + + V DP + E + LP
Sbjct: 300 S---GNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLT 356
Query: 314 -----SITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVR 368
S +K A V+L + +Y+ GG + + + Y + + W + +N+
Sbjct: 357 EHELESENKKWVEFACVTLKNEVYISGGKE-----TQHDVWKYNSSIN-KWIQIEYLNIG 410
Query: 369 RGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVI 428
R LG +YV GGFDG +R ++E YDP + WS + +
Sbjct: 411 RWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKL 470
Query: 429 YCL-GGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHL 487
Y + GG +G + + YDP T W+ M + D IYVVGG +
Sbjct: 471 YVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG-----AM 525
Query: 488 SSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYD-GNSLLSSIECYDP 542
++ AY+ DSW VT ++ R G RLY G D N +++++ C+DP
Sbjct: 526 RALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDP 581
Score = 46.2 bits (108), Expect = 8e-05
Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 3/77 (3%)
Query: 471 LNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDG 530
L + +Y+ GG + T H V YN + W + + R VL G++Y I G+DG
Sbjct: 375 LKNEVYISGGKE-TQH--DVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDG 431
Query: 531 NSLLSSIECYDPIIDSW 547
++++E YDP + W
Sbjct: 432 LQRINNVETYDPFHNCW 448
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 258 bits (658), Expect = 1e-68
Identities = 171/558 (30%), Positives = 269/558 (48%), Gaps = 31/558 (5%)
Query: 14 THAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPY 73
+H +L +N+LRK DVTL + FP HR VLAA S YF AMF+ L E
Sbjct: 27 SHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDT 86
Query: 74 VDIQ-GLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDP 132
V+ Q L +E+LLDF Y+ + + EN + LL A +LQ V+ A EFLE L P
Sbjct: 87 VNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFP 146
Query: 133 SNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDS 192
SNCLG+ ++ H C L + + HF V Q E+F LS+ + LI DE++ +
Sbjct: 147 SNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETED 206
Query: 193 EEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLV 252
E VFEA++ WVKH + R+ LP LL+ VR+ LL + + + +E + + + ++
Sbjct: 207 ERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIM 266
Query: 253 DEAKKFHLR-PELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSF 311
DEA + R + + P R R A LL++GG Q D + + D K +E
Sbjct: 267 DEALRCKTRILQNDGVVTSPCARPR-KAGHTLLILGG---QTFMCDKIYQVDHKAKEIIP 322
Query: 312 LPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGL 371
+ R+ ++ ++ ++YV GG + +S + T E+ W APM + R
Sbjct: 323 KADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEE--WSKAAPMLIARFG 380
Query: 372 AGATTLGDMIYVSGGFDGSRRHTSM---------------ERYDPNIDQWSMLGDMQTAR 416
G+ L + +YV GG HTS+ E+YDP ++W M+ ++
Sbjct: 381 HGSAELENCLYVVGG------HTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGV 434
Query: 417 EGAGLVVASGVIYCLGGYD-GLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHI 475
A +V A ++ GG ++++ V+ YDP WT A+L I
Sbjct: 435 SNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQI 494
Query: 476 YVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLS 535
+++GG D +S ++ T+ WT + MT R A +LY + GY G
Sbjct: 495 FIMGG-DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCK 553
Query: 536 SIECYDPIIDSWEVVTSM 553
+++CYDP D+W +T++
Sbjct: 554 TLDCYDPTSDTWNCITTV 571
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 250 bits (638), Expect = 3e-66
Identities = 158/567 (27%), Positives = 273/567 (48%), Gaps = 16/567 (2%)
Query: 12 TNTHAKSILNSMNSLRKSNTLCDVTLRVEQKD--FPAHRIVLAACSDYFCAMFTSELSEK 69
+NTH+ +L + LR LCDVTL D FP HR ++A+ SDYF AMFT + E+
Sbjct: 29 SNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQ 88
Query: 70 GKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQ 129
+ + G+ ++ ++DF+YT + + ++N+Q+ L AA LQ+ V C FL S
Sbjct: 89 DLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISG 148
Query: 130 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQ 189
+ NC+ + A T+N +++ + F K+FP ++ EF+ L + ++ + ++
Sbjct: 149 VSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLK 208
Query: 190 VDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCR 249
+E +F+A W++ + R + L++ +R PL+TP+ + + + F+R C
Sbjct: 209 HCTELELFKAACRWLR-LEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCV 267
Query: 250 DLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPID-VVEKYDPKTQE 308
+L+ EA + + P ++ MQ RT R + L+ +GG QQ + + YD + QE
Sbjct: 268 NLLLEASNYQMMPYMQPVMQSDRTAIRSDSTH-LVTLGGVLRQQLVVSKELRMYDERAQE 326
Query: 309 WSFLPSITRKRRYVASVSLHDRIYVIGG---YDGRSRLSSVECLDYTADEDGVWYSVAPM 365
W L + R + + +YV+GG YD + + ++V+ + W VA +
Sbjct: 327 WRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGK-TAVDTVFRFDPRYNKWMQVASL 385
Query: 366 NVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVAS 425
N +R + L +Y GG + ++E Y+P +++WS + M G V
Sbjct: 386 NEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYG 445
Query: 426 GVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGG--FDG 483
G++Y GG N + +DP T W PM T R + + D +YV+GG F G
Sbjct: 446 GLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRG 505
Query: 484 TAHLSSV---EAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNS--LLSSIE 538
T+ V E Y+ D WT + +M + VG V ++Y + GY N+ ++ ++
Sbjct: 506 TSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQ 565
Query: 539 CYDPIIDSWEVVTSMGTQRCDAGVCVL 565
YDP D W V + C L
Sbjct: 566 KYDPEKDEWHKVFDLPESLGGIRACTL 592
Score = 93.6 bits (231), Expect = 4e-19
Identities = 52/178 (29%), Positives = 81/178 (45%), Gaps = 5/178 (2%)
Query: 396 MERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGG---YD--GLNILNSVEKYDPHT 450
+ YD +W L M R G+ V +Y +GG YD G +++V ++DP
Sbjct: 317 LRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRY 376
Query: 451 GHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPR 510
W V + KR+ ++ L H+Y VGG L++VE YN R + W+ V M+ P
Sbjct: 377 NKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPH 436
Query: 511 CYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLREK 568
TV G +Y G ++ + + C+DP D W M T R +C + +K
Sbjct: 437 YGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDK 494
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 249 bits (635), Expect = 6e-66
Identities = 181/544 (33%), Positives = 258/544 (47%), Gaps = 25/544 (4%)
Query: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQ-KDFPAHRIVLAACSDYFCAMFTSELSEKGKPY 73
HA S+L ++ LR DVTL +DFPAHR VLAA S YF AMF +L E
Sbjct: 17 HALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAER 76
Query: 74 VDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPS 133
V + G+ +++LLDF YT V V+ +N + LL AA LLQ VK+AC FL+ QLD +
Sbjct: 77 VRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLA 136
Query: 134 NCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSE 193
NCL ++DFAE +C L AA+ F +H E + E+ L + + ++ D + V E
Sbjct: 137 NCLDMQDFAEAFSCSGLASAAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPKE 195
Query: 194 EPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVD 253
E ++ + WV+ R P LL+ VR+P + Y+ ++AEP + C L+
Sbjct: 196 EAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLR 255
Query: 254 EAKKFH-LRPELRSQMQGPRTRAR--LGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWS 310
EA+ F R + + PR R R G E+L++VGG + V+ Y+P+T +W
Sbjct: 256 EARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWR 315
Query: 311 FLPSI-TRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRR 369
+L + V+L + IYV GG DG SRL +C+ W VAPM R
Sbjct: 316 YLAEFPDHLGGGYSIVALGNDIYVTGGSDG-SRL--YDCVWRYNSSVNEWAEVAPMLKAR 372
Query: 370 GLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIY 429
++ L ++YV S ERYD D W L M + G +Y
Sbjct: 373 EYHSSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLY 425
Query: 430 CLGGYDGLNILNSVEKYDPHTGHWTNVT--PMATKRSGAGVALLNDHIYVVGGFDGTAHL 487
+G G + ++ YDP T W+ V + A LN +Y V D +A
Sbjct: 426 AIGSLAGKETM-VMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVR--DDSA-- 480
Query: 488 SSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSS-IECYDPIIDS 546
V+ YN + W + SM VL G+LY GYD LS +E YDP +
Sbjct: 481 -EVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRA 539
Query: 547 WEVV 550
W VV
Sbjct: 540 WSVV 543
Score = 65.1 bits (157), Expect = 2e-10
Identities = 42/129 (32%), Positives = 58/129 (44%), Gaps = 9/129 (6%)
Query: 427 VIYCLGGYD-GLNILNSVEKYDPHTGHWTNVTPMATKRSGA-GVALLNDHIYVVGGFDGT 484
++ +GG D + L +V+ Y+P TG W + G + L + IYV GG DG+
Sbjct: 287 ILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGS 346
Query: 485 AHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPII 544
V YN + W V M R Y ++VL G LY +A S E YD
Sbjct: 347 RLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAA-------DSTERYDHTT 399
Query: 545 DSWEVVTSM 553
DSWE + M
Sbjct: 400 DSWEALQPM 408
Score = 33.9 bits (76), Expect = 0.41
Identities = 17/45 (37%), Positives = 25/45 (55%)
Query: 283 LLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSL 327
L V GG+ + DVVE YDP+T+ WS + + + SVS+
Sbjct: 514 LYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSI 558
Score = 32.0 bits (71), Expect = 1.6
Identities = 28/114 (24%), Positives = 45/114 (39%), Gaps = 14/114 (12%)
Query: 445 KYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA-HLSSVEAYNIRTDSWTTV 503
+YD H P R G+A + + +VGG D L +V+ YN +T W +
Sbjct: 264 RYDRHD---RGPCPRMRPRPSTGLAEI---LVLVGGCDQDCDELVTVDCYNPQTGQWRYL 317
Query: 504 TSMTTPRCYVGA----TVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSM 553
++G L +Y G DG+ L + Y+ ++ W V M
Sbjct: 318 AEFPD---HLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPM 368
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,971,356
Number of Sequences: 37866
Number of extensions: 901187
Number of successful extensions: 3324
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 177
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 1856
Number of HSP's gapped (non-prelim): 398
length of query: 568
length of database: 18,247,518
effective HSP length: 108
effective length of query: 460
effective length of database: 14,157,990
effective search space: 6512675400
effective search space used: 6512675400
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.