Guide to the Human Genome
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Search of human proteins with 154759291

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|154759291 serine (or cysteine) proteinase inhibitor, clade A
(alpha-1 antiproteinase, antitrypsin), member 10 [Homo sapiens]
         (444 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|154759291 serine (or cysteine) proteinase inhibitor, clade A ...   885   0.0  
gi|7705879 serine (or cysteine) proteinase inhibitor, clade A (a...   885   0.0  
gi|27777657 serine (or cysteine) proteinase inhibitor, clade A (...   216   4e-56
gi|189163542 serine proteinase inhibitor, clade A, member 1 [Hom...   213   2e-55
gi|189163540 serine proteinase inhibitor, clade A, member 1 [Hom...   213   2e-55
gi|189163538 serine proteinase inhibitor, clade A, member 1 [Hom...   213   2e-55
gi|189163536 serine proteinase inhibitor, clade A, member 1 [Hom...   213   2e-55
gi|189163534 serine proteinase inhibitor, clade A, member 1 [Hom...   213   2e-55
gi|189163532 serine proteinase inhibitor, clade A, member 1 [Hom...   213   2e-55
gi|189163530 serine proteinase inhibitor, clade A, member 1 [Hom...   213   2e-55
gi|189163528 serine proteinase inhibitor, clade A, member 1 [Hom...   213   2e-55
gi|50363219 serine proteinase inhibitor, clade A, member 1 [Homo...   213   2e-55
gi|50363221 serine proteinase inhibitor, clade A, member 1 [Homo...   213   2e-55
gi|50363217 serine proteinase inhibitor, clade A, member 1 [Homo...   213   2e-55
gi|50659080 serpin peptidase inhibitor, clade A, member 3 precur...   202   5e-52
gi|194018472 serine (or cysteine) proteinase inhibitor, clade A ...   190   2e-48
gi|205277441 serine (or cysteine) proteinase inhibitor, clade A,...   189   4e-48
gi|110225347 serine (or cysteine) proteinase inhibitor, clade A ...   186   3e-47
gi|73858564 corticosteroid binding globulin precursor [Homo sapi...   186   5e-47
gi|73858566 heparin cofactor II precursor [Homo sapiens]              181   9e-46
gi|5453886 serpin peptidase inhibitor, clade I (pancpin), member...   169   6e-42
gi|13489087 serine (or cysteine) proteinase inhibitor, clade B (...   167   2e-41
gi|21361302 serine (or cysteine) proteinase inhibitor, clade A (...   164   1e-40
gi|170295807 neuroserpin precursor [Homo sapiens]                     163   3e-40
gi|4826904 neuroserpin precursor [Homo sapiens]                       163   3e-40
gi|122937297 serpin peptidase inhibitor, clade A (alpha-1 antipr...   162   6e-40
gi|4758906 serpin peptidase inhibitor, clade B, member 9 [Homo s...   159   4e-39
gi|4502261 serpin peptidase inhibitor, clade C, member 1 [Homo s...   158   1e-38
gi|156071456 serpin peptidase inhibitor, clade B, member 11 [Hom...   154   2e-37
gi|41152086 serine (or cysteine) proteinase inhibitor, clade B (...   151   1e-36

>gi|154759291 serine (or cysteine) proteinase inhibitor, clade A
           (alpha-1 antiproteinase, antitrypsin), member 10 [Homo
           sapiens]
          Length = 444

 Score =  885 bits (2288), Expect = 0.0
 Identities = 444/444 (100%), Positives = 444/444 (100%)

Query: 1   MKVVPSLLLSVLLAQVWLVPGLAPSPQSPETPAPQNQTSRVVQAPKEEEEDEQEASEEKA 60
           MKVVPSLLLSVLLAQVWLVPGLAPSPQSPETPAPQNQTSRVVQAPKEEEEDEQEASEEKA
Sbjct: 1   MKVVPSLLLSVLLAQVWLVPGLAPSPQSPETPAPQNQTSRVVQAPKEEEEDEQEASEEKA 60

Query: 61  SEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDGNMVFSPFGMSLAMTGLMLGATGPT 120
           SEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDGNMVFSPFGMSLAMTGLMLGATGPT
Sbjct: 61  SEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDGNMVFSPFGMSLAMTGLMLGATGPT 120

Query: 121 ETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKETFFN 180
           ETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKETFFN
Sbjct: 121 ETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKETFFN 180

Query: 181 LSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKG 240
           LSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKG
Sbjct: 181 LSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKG 240

Query: 241 KWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLV 300
           KWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLV
Sbjct: 241 KWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLV 300

Query: 301 VLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRI 360
           VLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRI
Sbjct: 301 VLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRI 360

Query: 361 FSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMPPVIKVDRPF 420
           FSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMPPVIKVDRPF
Sbjct: 361 FSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMPPVIKVDRPF 420

Query: 421 HFMIYEETSGMLLFLGRVVNPTLL 444
           HFMIYEETSGMLLFLGRVVNPTLL
Sbjct: 421 HFMIYEETSGMLLFLGRVVNPTLL 444


>gi|7705879 serine (or cysteine) proteinase inhibitor, clade A
           (alpha-1 antiproteinase, antitrypsin), member 10 [Homo
           sapiens]
          Length = 444

 Score =  885 bits (2288), Expect = 0.0
 Identities = 444/444 (100%), Positives = 444/444 (100%)

Query: 1   MKVVPSLLLSVLLAQVWLVPGLAPSPQSPETPAPQNQTSRVVQAPKEEEEDEQEASEEKA 60
           MKVVPSLLLSVLLAQVWLVPGLAPSPQSPETPAPQNQTSRVVQAPKEEEEDEQEASEEKA
Sbjct: 1   MKVVPSLLLSVLLAQVWLVPGLAPSPQSPETPAPQNQTSRVVQAPKEEEEDEQEASEEKA 60

Query: 61  SEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDGNMVFSPFGMSLAMTGLMLGATGPT 120
           SEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDGNMVFSPFGMSLAMTGLMLGATGPT
Sbjct: 61  SEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDGNMVFSPFGMSLAMTGLMLGATGPT 120

Query: 121 ETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKETFFN 180
           ETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKETFFN
Sbjct: 121 ETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKETFFN 180

Query: 181 LSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKG 240
           LSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKG
Sbjct: 181 LSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKG 240

Query: 241 KWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLV 300
           KWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLV
Sbjct: 241 KWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLV 300

Query: 301 VLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRI 360
           VLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRI
Sbjct: 301 VLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRI 360

Query: 361 FSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMPPVIKVDRPF 420
           FSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMPPVIKVDRPF
Sbjct: 361 FSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMPPVIKVDRPF 420

Query: 421 HFMIYEETSGMLLFLGRVVNPTLL 444
           HFMIYEETSGMLLFLGRVVNPTLL
Sbjct: 421 HFMIYEETSGMLLFLGRVVNPTLL 444


>gi|27777657 serine (or cysteine) proteinase inhibitor, clade A
           (alpha-1 antiproteinase, antitrypsin), member 12 [Homo
           sapiens]
          Length = 414

 Score =  216 bits (549), Expect = 4e-56
 Identities = 119/385 (30%), Positives = 212/385 (55%), Gaps = 6/385 (1%)

Query: 59  KASEEEKAWLMA-SRQQLAKETSNFGFSLLRKISMRHDGNMVF-SPFGMSLAMTGLMLGA 116
           KA  E + W    + ++LA++  + GF LL+K++  + G  +F SP  +S A + L LGA
Sbjct: 31  KALSEVQGWKQRMAAKELARQNMDLGFKLLKKLAFYNPGRNIFLSPLSISTAFSMLCLGA 90

Query: 117 TGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKE 176
              T  +IK+G + +  K  +  L       + E   +  +L L+ G+  FI +    + 
Sbjct: 91  QDSTLDEIKQGFNFR--KMPEKDLHEGFHYIIHELTQKTQDLKLSIGNTLFIDQRLQPQR 148

Query: 177 TFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYI 236
            F   +K ++  E +  NF+N   A++ +N +I+++T GKI  L + I+P T ++L +YI
Sbjct: 149 KFLEDAKNFYSAETILTNFQNLEMAQKQINDFISQKTHGKINNLIENIDPGTVMLLANYI 208

Query: 237 LFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNA 296
            F+ +W   FDP  T+ + F L+K  ++KVPMM+ +G +   +D    C +L++PYQ N 
Sbjct: 209 FFRARWKHEFDPNVTKEEDFFLEKNSSVKVPMMFRSGIYQVGYDDKLSCTILEIPYQKNI 268

Query: 297 TMLVVLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMG 356
           T + +L ++ G    LE  L  D    W   +  R ++V  P+  +   +++ + L  +G
Sbjct: 269 TAIFILPDE-GKLKHLEKGLQVDTFSRWKTLLSRRVVDVSVPRLHMTGTFDLKKTLSYIG 327

Query: 357 IRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMPPVIKV 416
           + +IF    DL+++ A  R+L+V   + +  +++DERGTE  AG  ++      P V+K+
Sbjct: 328 VSKIFEEHGDLTKI-APHRSLKVGEAVHKAELKMDERGTEGAAGTGAQTLPMETPLVVKI 386

Query: 417 DRPFHFMIYEETSGMLLFLGRVVNP 441
           D+P+  +IY E    +LFLG++VNP
Sbjct: 387 DKPYLLLIYSEKIPSVLFLGKIVNP 411


>gi|189163542 serine proteinase inhibitor, clade A, member 1 [Homo
           sapiens]
          Length = 418

 Score =  213 bits (543), Expect = 2e-55
 Identities = 127/399 (31%), Positives = 211/399 (52%), Gaps = 3/399 (0%)

Query: 45  PKEEEEDEQEASEEKASEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDG-NMVFSPF 103
           P    ED Q  + +K           +  ++    + F FSL R+++ + +  N+ FSP 
Sbjct: 20  PVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPV 79

Query: 104 GMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQG 163
            ++ A   L LG    T  +I  GL+    +  +  +     + LR     + +L LT G
Sbjct: 80  SIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTG 139

Query: 164 SFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDE 223
           +  F+ +   + + F    K+ + +E   +NF +  +AK+ +N Y+ K T+GKI  L  E
Sbjct: 140 NGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKE 199

Query: 224 INPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNF 283
           ++ +T   LV+YI FKGKW  PF+   TE + FH+D+  T+KVPMM   G F     K  
Sbjct: 200 LDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKL 259

Query: 284 RCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLD 343
              VL + Y GNAT +  L ++ G    LE+ LT D++  +L N   R+  +  PK  + 
Sbjct: 260 SSWVLLMKYLGNATAIFFLPDE-GKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318

Query: 344 QKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILS 403
             Y++  +L Q+GI ++FS  ADLS ++     L++S+ + + V+ +DE+GTEA   +  
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEA-PLKLSKAVHKAVLTIDEKGTEAAGAMFL 377

Query: 404 EITAYSMPPVIKVDRPFHFMIYEETSGMLLFLGRVVNPT 442
           E    S+PP +K ++PF F++ E+ +   LF+G+VVNPT
Sbjct: 378 EAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPT 416


>gi|189163540 serine proteinase inhibitor, clade A, member 1 [Homo
           sapiens]
          Length = 418

 Score =  213 bits (543), Expect = 2e-55
 Identities = 127/399 (31%), Positives = 211/399 (52%), Gaps = 3/399 (0%)

Query: 45  PKEEEEDEQEASEEKASEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDG-NMVFSPF 103
           P    ED Q  + +K           +  ++    + F FSL R+++ + +  N+ FSP 
Sbjct: 20  PVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPV 79

Query: 104 GMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQG 163
            ++ A   L LG    T  +I  GL+    +  +  +     + LR     + +L LT G
Sbjct: 80  SIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTG 139

Query: 164 SFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDE 223
           +  F+ +   + + F    K+ + +E   +NF +  +AK+ +N Y+ K T+GKI  L  E
Sbjct: 140 NGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKE 199

Query: 224 INPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNF 283
           ++ +T   LV+YI FKGKW  PF+   TE + FH+D+  T+KVPMM   G F     K  
Sbjct: 200 LDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKL 259

Query: 284 RCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLD 343
              VL + Y GNAT +  L ++ G    LE+ LT D++  +L N   R+  +  PK  + 
Sbjct: 260 SSWVLLMKYLGNATAIFFLPDE-GKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318

Query: 344 QKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILS 403
             Y++  +L Q+GI ++FS  ADLS ++     L++S+ + + V+ +DE+GTEA   +  
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEA-PLKLSKAVHKAVLTIDEKGTEAAGAMFL 377

Query: 404 EITAYSMPPVIKVDRPFHFMIYEETSGMLLFLGRVVNPT 442
           E    S+PP +K ++PF F++ E+ +   LF+G+VVNPT
Sbjct: 378 EAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPT 416


>gi|189163538 serine proteinase inhibitor, clade A, member 1 [Homo
           sapiens]
          Length = 418

 Score =  213 bits (543), Expect = 2e-55
 Identities = 127/399 (31%), Positives = 211/399 (52%), Gaps = 3/399 (0%)

Query: 45  PKEEEEDEQEASEEKASEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDG-NMVFSPF 103
           P    ED Q  + +K           +  ++    + F FSL R+++ + +  N+ FSP 
Sbjct: 20  PVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPV 79

Query: 104 GMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQG 163
            ++ A   L LG    T  +I  GL+    +  +  +     + LR     + +L LT G
Sbjct: 80  SIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTG 139

Query: 164 SFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDE 223
           +  F+ +   + + F    K+ + +E   +NF +  +AK+ +N Y+ K T+GKI  L  E
Sbjct: 140 NGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKE 199

Query: 224 INPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNF 283
           ++ +T   LV+YI FKGKW  PF+   TE + FH+D+  T+KVPMM   G F     K  
Sbjct: 200 LDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKL 259

Query: 284 RCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLD 343
              VL + Y GNAT +  L ++ G    LE+ LT D++  +L N   R+  +  PK  + 
Sbjct: 260 SSWVLLMKYLGNATAIFFLPDE-GKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318

Query: 344 QKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILS 403
             Y++  +L Q+GI ++FS  ADLS ++     L++S+ + + V+ +DE+GTEA   +  
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEA-PLKLSKAVHKAVLTIDEKGTEAAGAMFL 377

Query: 404 EITAYSMPPVIKVDRPFHFMIYEETSGMLLFLGRVVNPT 442
           E    S+PP +K ++PF F++ E+ +   LF+G+VVNPT
Sbjct: 378 EAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPT 416


>gi|189163536 serine proteinase inhibitor, clade A, member 1 [Homo
           sapiens]
          Length = 418

 Score =  213 bits (543), Expect = 2e-55
 Identities = 127/399 (31%), Positives = 211/399 (52%), Gaps = 3/399 (0%)

Query: 45  PKEEEEDEQEASEEKASEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDG-NMVFSPF 103
           P    ED Q  + +K           +  ++    + F FSL R+++ + +  N+ FSP 
Sbjct: 20  PVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPV 79

Query: 104 GMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQG 163
            ++ A   L LG    T  +I  GL+    +  +  +     + LR     + +L LT G
Sbjct: 80  SIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTG 139

Query: 164 SFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDE 223
           +  F+ +   + + F    K+ + +E   +NF +  +AK+ +N Y+ K T+GKI  L  E
Sbjct: 140 NGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKE 199

Query: 224 INPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNF 283
           ++ +T   LV+YI FKGKW  PF+   TE + FH+D+  T+KVPMM   G F     K  
Sbjct: 200 LDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKL 259

Query: 284 RCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLD 343
              VL + Y GNAT +  L ++ G    LE+ LT D++  +L N   R+  +  PK  + 
Sbjct: 260 SSWVLLMKYLGNATAIFFLPDE-GKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318

Query: 344 QKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILS 403
             Y++  +L Q+GI ++FS  ADLS ++     L++S+ + + V+ +DE+GTEA   +  
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEA-PLKLSKAVHKAVLTIDEKGTEAAGAMFL 377

Query: 404 EITAYSMPPVIKVDRPFHFMIYEETSGMLLFLGRVVNPT 442
           E    S+PP +K ++PF F++ E+ +   LF+G+VVNPT
Sbjct: 378 EAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPT 416


>gi|189163534 serine proteinase inhibitor, clade A, member 1 [Homo
           sapiens]
          Length = 418

 Score =  213 bits (543), Expect = 2e-55
 Identities = 127/399 (31%), Positives = 211/399 (52%), Gaps = 3/399 (0%)

Query: 45  PKEEEEDEQEASEEKASEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDG-NMVFSPF 103
           P    ED Q  + +K           +  ++    + F FSL R+++ + +  N+ FSP 
Sbjct: 20  PVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPV 79

Query: 104 GMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQG 163
            ++ A   L LG    T  +I  GL+    +  +  +     + LR     + +L LT G
Sbjct: 80  SIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTG 139

Query: 164 SFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDE 223
           +  F+ +   + + F    K+ + +E   +NF +  +AK+ +N Y+ K T+GKI  L  E
Sbjct: 140 NGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKE 199

Query: 224 INPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNF 283
           ++ +T   LV+YI FKGKW  PF+   TE + FH+D+  T+KVPMM   G F     K  
Sbjct: 200 LDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKL 259

Query: 284 RCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLD 343
              VL + Y GNAT +  L ++ G    LE+ LT D++  +L N   R+  +  PK  + 
Sbjct: 260 SSWVLLMKYLGNATAIFFLPDE-GKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318

Query: 344 QKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILS 403
             Y++  +L Q+GI ++FS  ADLS ++     L++S+ + + V+ +DE+GTEA   +  
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEA-PLKLSKAVHKAVLTIDEKGTEAAGAMFL 377

Query: 404 EITAYSMPPVIKVDRPFHFMIYEETSGMLLFLGRVVNPT 442
           E    S+PP +K ++PF F++ E+ +   LF+G+VVNPT
Sbjct: 378 EAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPT 416


>gi|189163532 serine proteinase inhibitor, clade A, member 1 [Homo
           sapiens]
          Length = 418

 Score =  213 bits (543), Expect = 2e-55
 Identities = 127/399 (31%), Positives = 211/399 (52%), Gaps = 3/399 (0%)

Query: 45  PKEEEEDEQEASEEKASEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDG-NMVFSPF 103
           P    ED Q  + +K           +  ++    + F FSL R+++ + +  N+ FSP 
Sbjct: 20  PVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPV 79

Query: 104 GMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQG 163
            ++ A   L LG    T  +I  GL+    +  +  +     + LR     + +L LT G
Sbjct: 80  SIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTG 139

Query: 164 SFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDE 223
           +  F+ +   + + F    K+ + +E   +NF +  +AK+ +N Y+ K T+GKI  L  E
Sbjct: 140 NGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKE 199

Query: 224 INPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNF 283
           ++ +T   LV+YI FKGKW  PF+   TE + FH+D+  T+KVPMM   G F     K  
Sbjct: 200 LDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKL 259

Query: 284 RCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLD 343
              VL + Y GNAT +  L ++ G    LE+ LT D++  +L N   R+  +  PK  + 
Sbjct: 260 SSWVLLMKYLGNATAIFFLPDE-GKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318

Query: 344 QKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILS 403
             Y++  +L Q+GI ++FS  ADLS ++     L++S+ + + V+ +DE+GTEA   +  
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEA-PLKLSKAVHKAVLTIDEKGTEAAGAMFL 377

Query: 404 EITAYSMPPVIKVDRPFHFMIYEETSGMLLFLGRVVNPT 442
           E    S+PP +K ++PF F++ E+ +   LF+G+VVNPT
Sbjct: 378 EAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPT 416


>gi|189163530 serine proteinase inhibitor, clade A, member 1 [Homo
           sapiens]
          Length = 418

 Score =  213 bits (543), Expect = 2e-55
 Identities = 127/399 (31%), Positives = 211/399 (52%), Gaps = 3/399 (0%)

Query: 45  PKEEEEDEQEASEEKASEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDG-NMVFSPF 103
           P    ED Q  + +K           +  ++    + F FSL R+++ + +  N+ FSP 
Sbjct: 20  PVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPV 79

Query: 104 GMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQG 163
            ++ A   L LG    T  +I  GL+    +  +  +     + LR     + +L LT G
Sbjct: 80  SIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTG 139

Query: 164 SFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDE 223
           +  F+ +   + + F    K+ + +E   +NF +  +AK+ +N Y+ K T+GKI  L  E
Sbjct: 140 NGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKE 199

Query: 224 INPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNF 283
           ++ +T   LV+YI FKGKW  PF+   TE + FH+D+  T+KVPMM   G F     K  
Sbjct: 200 LDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKL 259

Query: 284 RCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLD 343
              VL + Y GNAT +  L ++ G    LE+ LT D++  +L N   R+  +  PK  + 
Sbjct: 260 SSWVLLMKYLGNATAIFFLPDE-GKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318

Query: 344 QKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILS 403
             Y++  +L Q+GI ++FS  ADLS ++     L++S+ + + V+ +DE+GTEA   +  
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEA-PLKLSKAVHKAVLTIDEKGTEAAGAMFL 377

Query: 404 EITAYSMPPVIKVDRPFHFMIYEETSGMLLFLGRVVNPT 442
           E    S+PP +K ++PF F++ E+ +   LF+G+VVNPT
Sbjct: 378 EAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPT 416


>gi|189163528 serine proteinase inhibitor, clade A, member 1 [Homo
           sapiens]
          Length = 418

 Score =  213 bits (543), Expect = 2e-55
 Identities = 127/399 (31%), Positives = 211/399 (52%), Gaps = 3/399 (0%)

Query: 45  PKEEEEDEQEASEEKASEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDG-NMVFSPF 103
           P    ED Q  + +K           +  ++    + F FSL R+++ + +  N+ FSP 
Sbjct: 20  PVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPV 79

Query: 104 GMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQG 163
            ++ A   L LG    T  +I  GL+    +  +  +     + LR     + +L LT G
Sbjct: 80  SIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTG 139

Query: 164 SFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDE 223
           +  F+ +   + + F    K+ + +E   +NF +  +AK+ +N Y+ K T+GKI  L  E
Sbjct: 140 NGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKE 199

Query: 224 INPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNF 283
           ++ +T   LV+YI FKGKW  PF+   TE + FH+D+  T+KVPMM   G F     K  
Sbjct: 200 LDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKL 259

Query: 284 RCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLD 343
              VL + Y GNAT +  L ++ G    LE+ LT D++  +L N   R+  +  PK  + 
Sbjct: 260 SSWVLLMKYLGNATAIFFLPDE-GKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318

Query: 344 QKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILS 403
             Y++  +L Q+GI ++FS  ADLS ++     L++S+ + + V+ +DE+GTEA   +  
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEA-PLKLSKAVHKAVLTIDEKGTEAAGAMFL 377

Query: 404 EITAYSMPPVIKVDRPFHFMIYEETSGMLLFLGRVVNPT 442
           E    S+PP +K ++PF F++ E+ +   LF+G+VVNPT
Sbjct: 378 EAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPT 416


>gi|50363219 serine proteinase inhibitor, clade A, member 1 [Homo
           sapiens]
          Length = 418

 Score =  213 bits (543), Expect = 2e-55
 Identities = 127/399 (31%), Positives = 211/399 (52%), Gaps = 3/399 (0%)

Query: 45  PKEEEEDEQEASEEKASEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDG-NMVFSPF 103
           P    ED Q  + +K           +  ++    + F FSL R+++ + +  N+ FSP 
Sbjct: 20  PVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPV 79

Query: 104 GMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQG 163
            ++ A   L LG    T  +I  GL+    +  +  +     + LR     + +L LT G
Sbjct: 80  SIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTG 139

Query: 164 SFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDE 223
           +  F+ +   + + F    K+ + +E   +NF +  +AK+ +N Y+ K T+GKI  L  E
Sbjct: 140 NGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKE 199

Query: 224 INPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNF 283
           ++ +T   LV+YI FKGKW  PF+   TE + FH+D+  T+KVPMM   G F     K  
Sbjct: 200 LDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKL 259

Query: 284 RCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLD 343
              VL + Y GNAT +  L ++ G    LE+ LT D++  +L N   R+  +  PK  + 
Sbjct: 260 SSWVLLMKYLGNATAIFFLPDE-GKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318

Query: 344 QKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILS 403
             Y++  +L Q+GI ++FS  ADLS ++     L++S+ + + V+ +DE+GTEA   +  
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEA-PLKLSKAVHKAVLTIDEKGTEAAGAMFL 377

Query: 404 EITAYSMPPVIKVDRPFHFMIYEETSGMLLFLGRVVNPT 442
           E    S+PP +K ++PF F++ E+ +   LF+G+VVNPT
Sbjct: 378 EAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPT 416


>gi|50363221 serine proteinase inhibitor, clade A, member 1 [Homo
           sapiens]
          Length = 418

 Score =  213 bits (543), Expect = 2e-55
 Identities = 127/399 (31%), Positives = 211/399 (52%), Gaps = 3/399 (0%)

Query: 45  PKEEEEDEQEASEEKASEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDG-NMVFSPF 103
           P    ED Q  + +K           +  ++    + F FSL R+++ + +  N+ FSP 
Sbjct: 20  PVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPV 79

Query: 104 GMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQG 163
            ++ A   L LG    T  +I  GL+    +  +  +     + LR     + +L LT G
Sbjct: 80  SIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTG 139

Query: 164 SFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDE 223
           +  F+ +   + + F    K+ + +E   +NF +  +AK+ +N Y+ K T+GKI  L  E
Sbjct: 140 NGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKE 199

Query: 224 INPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNF 283
           ++ +T   LV+YI FKGKW  PF+   TE + FH+D+  T+KVPMM   G F     K  
Sbjct: 200 LDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKL 259

Query: 284 RCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLD 343
              VL + Y GNAT +  L ++ G    LE+ LT D++  +L N   R+  +  PK  + 
Sbjct: 260 SSWVLLMKYLGNATAIFFLPDE-GKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318

Query: 344 QKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILS 403
             Y++  +L Q+GI ++FS  ADLS ++     L++S+ + + V+ +DE+GTEA   +  
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEA-PLKLSKAVHKAVLTIDEKGTEAAGAMFL 377

Query: 404 EITAYSMPPVIKVDRPFHFMIYEETSGMLLFLGRVVNPT 442
           E    S+PP +K ++PF F++ E+ +   LF+G+VVNPT
Sbjct: 378 EAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPT 416


>gi|50363217 serine proteinase inhibitor, clade A, member 1 [Homo
           sapiens]
          Length = 418

 Score =  213 bits (543), Expect = 2e-55
 Identities = 127/399 (31%), Positives = 211/399 (52%), Gaps = 3/399 (0%)

Query: 45  PKEEEEDEQEASEEKASEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDG-NMVFSPF 103
           P    ED Q  + +K           +  ++    + F FSL R+++ + +  N+ FSP 
Sbjct: 20  PVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPV 79

Query: 104 GMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGLTQG 163
            ++ A   L LG    T  +I  GL+    +  +  +     + LR     + +L LT G
Sbjct: 80  SIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTG 139

Query: 164 SFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDE 223
           +  F+ +   + + F    K+ + +E   +NF +  +AK+ +N Y+ K T+GKI  L  E
Sbjct: 140 NGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKE 199

Query: 224 INPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNF 283
           ++ +T   LV+YI FKGKW  PF+   TE + FH+D+  T+KVPMM   G F     K  
Sbjct: 200 LDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKL 259

Query: 284 RCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLD 343
              VL + Y GNAT +  L ++ G    LE+ LT D++  +L N   R+  +  PK  + 
Sbjct: 260 SSWVLLMKYLGNATAIFFLPDE-GKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318

Query: 344 QKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILS 403
             Y++  +L Q+GI ++FS  ADLS ++     L++S+ + + V+ +DE+GTEA   +  
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEA-PLKLSKAVHKAVLTIDEKGTEAAGAMFL 377

Query: 404 EITAYSMPPVIKVDRPFHFMIYEETSGMLLFLGRVVNPT 442
           E    S+PP +K ++PF F++ E+ +   LF+G+VVNPT
Sbjct: 378 EAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPT 416


>gi|50659080 serpin peptidase inhibitor, clade A, member 3 precursor
           [Homo sapiens]
          Length = 423

 Score =  202 bits (514), Expect = 5e-52
 Identities = 127/377 (33%), Positives = 212/377 (56%), Gaps = 15/377 (3%)

Query: 75  LAKETSNFGFSLLRKISMRH-DGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQAL 133
           LA    +F FSL +++ ++  D N++FSP  +S A+  L LGA   T T+I +GL    L
Sbjct: 49  LASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFN-L 107

Query: 134 KPTKPGLLPSLFKGLRETLSRNL-ELGLTQGSFAFIHKDFDVKETFFNLSKRYFDTECVP 192
             T    +   F+ L  TL+++  EL L+ G+  F+ +   + + F   +KR + +E   
Sbjct: 108 TETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFA 167

Query: 193 MNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKGKWLTPFDPVFTE 252
            +F++++ AK+L+N Y+   TRGKI  L  +++ +T ++LV+YI FK KW  PFDP  T 
Sbjct: 168 TDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKWEMPFDPQDTH 227

Query: 253 VDTFHLDKYKTIKVPMMYGAGKFASTF-DKNFRCHVLKLPYQGNATMLVVL--MEKMGDH 309
              F+L K K + VPMM         F D+   C V++L Y GNA+ L +L   +KM + 
Sbjct: 228 QSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVELKYTGNASALFILPDQDKMEE- 286

Query: 310 LALEDYLTTDLVETWLRNMKTRNM-EVFFPKFKLDQKYEMHELLRQMGIRRIFSPFADLS 368
             +E  L  + ++ W  +++ R + E++ PKF + + Y ++++L Q+GI   F+  ADLS
Sbjct: 287 --VEAMLLPETLKRWRDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLS 344

Query: 369 ELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYS----MPPVIKVDRPFHFMI 424
            ++   RNL VS+V+ + V++V E GTEA A    +IT  S       +++ +RPF  +I
Sbjct: 345 GITG-ARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRFNRPFLMII 403

Query: 425 YEETSGMLLFLGRVVNP 441
               +  + F+ +V NP
Sbjct: 404 VPTDTQNIFFMSKVTNP 420


>gi|194018472 serine (or cysteine) proteinase inhibitor, clade A
           (alpha-1 antiproteinase, antitrypsin), member 5 [Homo
           sapiens]
          Length = 406

 Score =  190 bits (483), Expect = 2e-48
 Identities = 118/365 (32%), Positives = 195/365 (53%), Gaps = 9/365 (2%)

Query: 81  NFGFSLLRKI-SMRHDGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPG 139
           +F F L R + S     ++ FSP  +S+++  L LGA   T+ QI  GL L   K ++  
Sbjct: 47  DFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKE 106

Query: 140 LLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNAS 199
           L     + L+E         L+ G+  F     D+++TF +  K  +  +  P NFR+++
Sbjct: 107 LHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSA 166

Query: 200 QAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLD 259
            A + +N Y+ K+T+GKI  L   ++    +I+V+YI FK KW T F+   T+   F++ 
Sbjct: 167 GAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVT 226

Query: 260 KYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTTD 319
               ++VPMM    ++    D+N  C V+ +PYQGNAT L +L  + G    +E+ L+  
Sbjct: 227 SETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSE-GKMQQVENGLSEK 285

Query: 320 LVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQV 379
            +  WL+  K R +E++ PKF ++  Y++ ++L  +GI  +F+  ADLS +S    N+QV
Sbjct: 286 TLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGIS-NHSNIQV 344

Query: 380 SRVLQRTVIEVDERGTEAVAG---ILSEITAYSMPPVIKVDRPFHFMIYEETSGMLLFLG 436
           S ++ + V+EVDE GT A A    I +  +A      +  +RPF   I +     +LFLG
Sbjct: 345 SEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNN---ILFLG 401

Query: 437 RVVNP 441
           +V  P
Sbjct: 402 KVNRP 406


>gi|205277441 serine (or cysteine) proteinase inhibitor, clade A,
           member 7 [Homo sapiens]
          Length = 415

 Score =  189 bits (480), Expect = 4e-48
 Identities = 125/382 (32%), Positives = 205/382 (53%), Gaps = 14/382 (3%)

Query: 70  ASRQQLAKETSNFGFSLLRKISMRH-DGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGL 128
           A+  +++   ++F F+L R+ ++   D N+ FSP  +S A+  L  GA   T+T+I   L
Sbjct: 37  ATLYKMSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETL 96

Query: 129 HLQALKPTKPGLLPSLFKGLRETLS-RNLELGLTQGSFAFIHKDFDVKETFFNLSKRYFD 187
               L  T    +   F+ L  +L+    EL L  G+  FI K       F N  K  ++
Sbjct: 97  GFN-LTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYE 155

Query: 188 TECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKGKWLTPFD 247
           TE    +F N S AK+ +N ++  +T+GK+  L  ++ P T ++LV+YI FK +W  PFD
Sbjct: 156 TEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFD 215

Query: 248 PVFTE-VDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLVVLMEKM 306
           P  TE   +F +DK  T++VPMM+   ++    D    C VL++ Y  NA  L VL  K 
Sbjct: 216 PSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVL-PKE 274

Query: 307 GDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFSPFAD 366
           G   ++E  +++  ++ W R ++   +++F PKF +   Y++   L +MGI+  +S  AD
Sbjct: 275 GQMESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENAD 334

Query: 367 LSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMP------PVIKVDRPF 420
            S L+     L++S    + V+ + E+GTEA A  + E+     P      P+I++DR F
Sbjct: 335 FSGLT-EDNGLKLSNAAHKAVLHIGEKGTEAAA--VPEVELSDQPENTFLHPIIQIDRSF 391

Query: 421 HFMIYEETSGMLLFLGRVVNPT 442
             +I E ++  +LFLG+VVNPT
Sbjct: 392 MLLILERSTRSILFLGKVVNPT 413


>gi|110225347 serine (or cysteine) proteinase inhibitor, clade A
           (alpha-1 antiproteinase, antitrypsin), member 9 isoform
           A [Homo sapiens]
          Length = 435

 Score =  186 bits (473), Expect = 3e-47
 Identities = 120/376 (31%), Positives = 197/376 (52%), Gaps = 10/376 (2%)

Query: 74  QLAKETSNFGFSLLRKISMRHDG-NMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQA 132
           Q+    ++F F L R++ +     N+ FSP  +S ++  L LGA   T+TQI +GL    
Sbjct: 61  QVYSLNTDFAFRLYRRLVLETPSQNIFFSPVSVSTSLAMLSLGAHSVTKTQILQGLGFN- 119

Query: 133 LKPTKPGLLPSLFKGLRETLS-RNLELGLTQGSFAFIHKDFDVKETFFNLSKRYFDTECV 191
           L  T    +   F+ L  +L+  + +L L  GS  F+ K+  ++  F    KR ++ E  
Sbjct: 120 LTHTPESAIHQGFQHLVHSLTVPSKDLTLKMGSALFVKKELQLQANFLGNVKRLYEAEVF 179

Query: 192 PMNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKGKWLTPFDPVFT 251
             +F N S A+  +N ++ K+T+GK+  +   ++  T ++LV++I FK KW  PF P +T
Sbjct: 180 STDFSNPSIAQARINSHVKKKTQGKVVDIIQGLDLLTAMVLVNHIFFKAKWEKPFHPEYT 239

Query: 252 EVD-TFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLVVLMEKMGDHL 310
             +  F + +  T+ VPMM+   +FA   D    C VL++ Y+G+A    VL  K G   
Sbjct: 240 RKNFPFLVGEQVTVHVPMMHQKEQFAFGVDTELNCFVLQMDYKGDAVAFFVLPSK-GKMR 298

Query: 311 ALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFSPFADLSEL 370
            LE  L+   +  W  +++ R +EVF P+F +   Y +  +L +MGI+ +F   AD S +
Sbjct: 299 QLEQALSARTLRKWSHSLQKRWIEVFIPRFSISASYNLETILPKMGIQNVFDKNADFSGI 358

Query: 371 SATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMPP----VIKVDRPFHFMIYE 426
            A   +LQVS+   + V++V E GTEA A   ++    S        +  +R F  MI  
Sbjct: 359 -AKRDSLQVSKATHKAVLDVSEEGTEATAATTTKFIVRSKDGPSYFTVSFNRTFLMMITN 417

Query: 427 ETSGMLLFLGRVVNPT 442
           + +  +LFLG+V NPT
Sbjct: 418 KATDGILFLGKVENPT 433


>gi|73858564 corticosteroid binding globulin precursor [Homo
           sapiens]
          Length = 405

 Score =  186 bits (471), Expect = 5e-47
 Identities = 104/369 (28%), Positives = 199/369 (53%), Gaps = 5/369 (1%)

Query: 75  LAKETSNFGFSLLRK-ISMRHDGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQAL 133
           LA    +F FSL +  +++    N+  SP  +S+A+  L LG  G T  Q+ +GL     
Sbjct: 39  LASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLT 98

Query: 134 KPTKPGLLPSLFKGLRETLSRN-LELGLTQGSFAFIHKDFDVKETFFNLSKRYFDTECVP 192
           + ++  +    F+ L +  +++   L +T G+  F+    ++ E+F    K Y+++E + 
Sbjct: 99  ERSETEIHQG-FQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLA 157

Query: 193 MNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKGKWLTPFDPVFTE 252
           MNF++ + A R +N Y+  +T+GKI  LF  ++    L+LV+YI FKG W  PFD   T 
Sbjct: 158 MNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTR 217

Query: 253 VDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLVVLMEKMGDHLAL 312
            + F++D+   +KVPMM  +   +   D    C ++++ Y GN T+  +L +K G    +
Sbjct: 218 EENFYVDETTVVKVPMMLQSSTISYLHDAELPCQLVQMNYVGNGTVFFILPDK-GKMNTV 276

Query: 313 EDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFSPFADLSELSA 372
              L+ D +  W   + +  ++++ PK  +   Y++ ++L +MGI  +F+  A+ S ++ 
Sbjct: 277 IAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQ 336

Query: 373 TGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMPPVIKVDRPFHFMIYEETSGML 432
             + L+ S+V+ + V++++E G +        +   S P +++ ++PF  MI++  +   
Sbjct: 337 DAQ-LKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFIIMIFDHFTWSS 395

Query: 433 LFLGRVVNP 441
           LFL RV+NP
Sbjct: 396 LFLARVMNP 404


>gi|73858566 heparin cofactor II precursor [Homo sapiens]
          Length = 499

 Score =  181 bits (460), Expect = 9e-46
 Identities = 120/377 (31%), Positives = 186/377 (49%), Gaps = 10/377 (2%)

Query: 73  QQLAKETSNFGFSLLR--KISMRHDGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHL 130
           Q+L    + F F+L R  K  +    N+  +P G+S AM  + LG  G T  Q+   LH 
Sbjct: 124 QRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHF 183

Query: 131 Q----ALKPTKPGLLPSLFKGLRETL-SRNLELGLTQGSFAFIHKDFDVKETFFNLSKRY 185
           +    A    +   + +LF+ L   L  RN    L   +  +I K F +   F    + Y
Sbjct: 184 KDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREY 243

Query: 186 FDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKGKWLTP 245
           +  E    +F + +   +  NH I K T+G I    + I+P T++++++ I FKG W+  
Sbjct: 244 YFAEAQIADFSDPAFISKTNNH-IMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNK 302

Query: 246 FDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLVVLMEK 305
           F    T    F L++ + +KV MM   G F +  D+   C +L+L Y G  +ML+V+  K
Sbjct: 303 FPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHK 362

Query: 306 MGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFSPFA 365
           M     LE  LT  +VE W ++M  R  EV  PKFKL++ Y + E L+ MGIR +F    
Sbjct: 363 MSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNG 422

Query: 366 DLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMPPVIKVDRPFHFMIY 425
           +++ +S   + + +     +  I V+E GT+A           S      VDRPF F+IY
Sbjct: 423 NMAGIS--DQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIY 480

Query: 426 EETSGMLLFLGRVVNPT 442
           E  +  LLF+GRV NP+
Sbjct: 481 EHRTSCLLFMGRVANPS 497


>gi|5453886 serpin peptidase inhibitor, clade I (pancpin), member 2
           [Homo sapiens]
          Length = 405

 Score =  169 bits (427), Expect = 6e-42
 Identities = 105/374 (28%), Positives = 193/374 (51%), Gaps = 12/374 (3%)

Query: 76  AKETSNFGFSLLRKISMRHDGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQALKP 135
           A++ + F   L +++S+ H  N++FSP G++L +  + LGA G  + QI++ L  Q    
Sbjct: 23  AQKNTEFAVDLYQEVSLSHKDNIIFSPLGITLVLEMVQLGAKGKAQQQIRQTLKQQETSA 82

Query: 136 TKPG-LLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKETFFNLSKRYFDTECVPMN 194
            +   +L S F  + E   +  E      +  ++ + F VKE + + +K +F +    ++
Sbjct: 83  GEEFFVLKSFFSAISE---KKQEFTFNLANALYLQEGFTVKEQYLHGNKEFFQSAIKLVD 139

Query: 195 FRNASQAKRLMNHYINKETRGKIPKLF--DEINPETKLILVDYILFKGKWLTPFDPVFTE 252
           F++A     +++ ++ ++T GKI  +F  +E  P T+L+LV+ I FKG W   F    T+
Sbjct: 140 FQDAKACAEMISTWVERKTDGKIKDMFSGEEFGPLTRLVLVNAIYFKGDWKQKFRKEDTQ 199

Query: 253 VDTFHLDKYKTIKVPMMYGA--GKFASTFDKNFRCHVLKLPYQGNATMLVVLMEKMG-DH 309
           +  F      T+K+PMM      K+    + +    VL+L Y+G+   L++++   G D 
Sbjct: 200 LINFTKKNGSTVKIPMMKALLRTKYGYFSESSLNYQVLELSYKGDEFSLIIILPAEGMDI 259

Query: 310 LALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFSPFADLSE 369
             +E  +T   +  WL  M+   +E+  P+FK++QK +  ++L  + I  IFS   DLS 
Sbjct: 260 EEVEKLITAQQILKWLSEMQEEEVEISLPRFKVEQKVDFKDVLYSLNITEIFSGGCDLSG 319

Query: 370 LSATGRNLQVSRVLQRTVIEVDERGTEAV--AGILSEITAYSMPPVIKVDRPFHFMIYEE 427
           ++ +   + VS+V Q+   E++E G+EA    GI   +           + PF F++   
Sbjct: 320 ITDSS-EVYVSQVTQKVFFEINEDGSEAATSTGIHIPVIMSLAQSQFIANHPFLFIMKHN 378

Query: 428 TSGMLLFLGRVVNP 441
            +  +LF+GRV NP
Sbjct: 379 PTESILFMGRVTNP 392


>gi|13489087 serine (or cysteine) proteinase inhibitor, clade B
           (ovalbumin), member 1 [Homo sapiens]
          Length = 379

 Score =  167 bits (423), Expect = 2e-41
 Identities = 114/384 (29%), Positives = 197/384 (51%), Gaps = 21/384 (5%)

Query: 73  QQLAKETSNFGFSLLRKISMRHD-GNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQ 131
           +QL+   + F   L   +S  +  GN+  SPF +S AM  + LG  G T  Q+ +  H  
Sbjct: 2   EQLSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHFN 61

Query: 132 ALKPTKPGLLPSLFKGLRETLS-RNLELGLTQGSFAFIHKDFDVKETFFNLSKRYFDTEC 190
            ++        S F+ L   ++ R     L   +  +  K ++    F   +++ +  + 
Sbjct: 62  TVEEVH-----SRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADL 116

Query: 191 VPMNFRNASQ-AKRLMNHYINKETRGKIPKLFDE--INPETKLILVDYILFKGKWLTPFD 247
             ++F++AS+ A++ +N ++  +T GKIP+L     ++  TKL+LV+ I FKG W   F 
Sbjct: 117 ASVDFQHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFM 176

Query: 248 PVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLVVLM---- 303
              T    F L+K     V MMY   KFA  + ++ +C VL+LPYQG    +V+L+    
Sbjct: 177 KEATTNAPFRLNKKDRKTVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDI 236

Query: 304 -EKMGDHLALEDYLTTDLVETWLR--NMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRI 360
            ++      +E+ LT + +  W +  N+    + V  P+FKL++ Y ++  L ++G++ +
Sbjct: 237 EDESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDL 296

Query: 361 F-SPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMPPV--IKVD 417
           F S  ADLS +S   R++ +S+++ ++ +EV+E GTEA A      T   + P      D
Sbjct: 297 FNSSKADLSGMSG-ARDIFISKIVHKSFVEVNEEGTEAAAATAGIATFCMLMPEENFTAD 355

Query: 418 RPFHFMIYEETSGMLLFLGRVVNP 441
            PF F I   +SG +LFLGR  +P
Sbjct: 356 HPFLFFIRHNSSGSILFLGRFSSP 379


>gi|21361302 serine (or cysteine) proteinase inhibitor, clade A
           (alpha-1 antiproteinase, antitrypsin), member 4 [Homo
           sapiens]
          Length = 427

 Score =  164 bits (416), Expect = 1e-40
 Identities = 113/381 (29%), Positives = 195/381 (51%), Gaps = 17/381 (4%)

Query: 74  QLAKETSNFGFSLLRKISMRHDG-NMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQA 132
           ++A   ++F F     I+    G N+ FSP  +S A   L LGA   + +QI  GL    
Sbjct: 50  KIAPANADFAFRFYYLIASETPGKNIFFSPLSISAAYAMLSLGACSHSRSQILEGLGFNL 109

Query: 133 LKPTKPGLLPSLFKGLRETLS---RNLELGLTQGSFAFIHKDFDVKETFFNLSKRYFDTE 189
            + ++  +    F+ L  TL+     LE  +  GS  F+  +      F N +   ++ +
Sbjct: 110 TELSESDVHRG-FQHLLHTLNLPGHGLETRV--GSALFLSHNLKFLAKFLNDTMAVYEAK 166

Query: 190 CVPMNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKGKWLTPFDPV 249
               NF +     +L+N ++ KETRGKI  L  E+  +  ++LV+YI FK  W  PF   
Sbjct: 167 LFHTNFYDTVGTIQLINDHVKKETRGKIVDLVSELKKDVLMVLVNYIYFKALWEKPFISS 226

Query: 250 FTEVDTFHLDKYKTIKVPMMYGAGKFA-STFDKNFRCHVLKLPYQGNATMLVVLMEKMGD 308
            T    F++D+  T++VPMM    +      D+   C VL++ Y+G+AT+  +L    G 
Sbjct: 227 RTTPKDFYVDENTTVRVPMMLQDQEHHWYLHDRYLPCSVLRMDYKGDATVFFIL-PNQGK 285

Query: 309 HLALEDYLTTDLVETWLRNMKTRN----MEVFFPKFKLDQKYEMHELLRQMGIRRIFSPF 364
              +E+ LT +++  W   ++ RN    +E+  PKF +   Y + ++L ++G   +FS +
Sbjct: 286 MREIEEVLTPEMLMRWNNLLRKRNFYKKLELHLPKFSISGSYVLDQILPRLGFTDLFSKW 345

Query: 365 ADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMPP---VIKVDRPFH 421
           ADLS ++   + L+ S+   +  ++VDE GTEA A     I  +S      +++ +RPF 
Sbjct: 346 ADLSGITKQ-QKLEASKSFHKATLDVDEAGTEAAAATSFAIKFFSAQTNRHILRFNRPFL 404

Query: 422 FMIYEETSGMLLFLGRVVNPT 442
            +I+  ++  +LFLG+VV+PT
Sbjct: 405 VVIFSTSTQSVLFLGKVVDPT 425


>gi|170295807 neuroserpin precursor [Homo sapiens]
          Length = 410

 Score =  163 bits (412), Expect = 3e-40
 Identities = 98/358 (27%), Positives = 188/358 (52%), Gaps = 14/358 (3%)

Query: 95  DGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSR 154
           D N++FSP  ++LAM  + LGA G T+ +I+  +   +LK  +       F  +    ++
Sbjct: 43  DENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLKNGEEFSFLKEFSNM--VTAK 100

Query: 155 NLELGLTQGSFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETR 214
             +  +   +  F+   F V E F  + K+YF+     ++F         +N ++   T 
Sbjct: 101 ESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAAVNHVDFSQNVAVANYINKWVENNTN 160

Query: 215 GKIPKLFD--EINPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGA 272
             +  L    + +  T L L++ + FKG W + F P  T   +F  D    +++PMMY  
Sbjct: 161 NLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQ 220

Query: 273 GKFA------STFDKNFRCHVLKLPYQGNATMLVVLMEKMGDHLA-LEDYLTTDLVETWL 325
           G+F        + +      VL++PY+G+   +++++ +    LA LE  +   LVE W 
Sbjct: 221 GEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVPLATLEPLVKAQLVEEWA 280

Query: 326 RNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQR 385
            ++K + +EV+ P+F ++Q+ ++ ++L+ +GI  IF   A+L+ LS   + + +S+ + +
Sbjct: 281 NSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEIFIKDANLTGLS-DNKEIFLSKAIHK 339

Query: 386 TVIEVDERGTE--AVAGILSEITAYSMPPVIKVDRPFHFMIYEETSGMLLFLGRVVNP 441
           + +EV+E G+E  AV+G+++      + P + VD PF F+I    +G +LF+GRV++P
Sbjct: 340 SFLEVNEEGSEAAAVSGMIAISRMAVLYPQVIVDHPFFFLIRNRRTGTILFMGRVMHP 397


>gi|4826904 neuroserpin precursor [Homo sapiens]
          Length = 410

 Score =  163 bits (412), Expect = 3e-40
 Identities = 98/358 (27%), Positives = 188/358 (52%), Gaps = 14/358 (3%)

Query: 95  DGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSR 154
           D N++FSP  ++LAM  + LGA G T+ +I+  +   +LK  +       F  +    ++
Sbjct: 43  DENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLKNGEEFSFLKEFSNM--VTAK 100

Query: 155 NLELGLTQGSFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETR 214
             +  +   +  F+   F V E F  + K+YF+     ++F         +N ++   T 
Sbjct: 101 ESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAAVNHVDFSQNVAVANYINKWVENNTN 160

Query: 215 GKIPKLFD--EINPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGA 272
             +  L    + +  T L L++ + FKG W + F P  T   +F  D    +++PMMY  
Sbjct: 161 NLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQ 220

Query: 273 GKFA------STFDKNFRCHVLKLPYQGNATMLVVLMEKMGDHLA-LEDYLTTDLVETWL 325
           G+F        + +      VL++PY+G+   +++++ +    LA LE  +   LVE W 
Sbjct: 221 GEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVPLATLEPLVKAQLVEEWA 280

Query: 326 RNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQR 385
            ++K + +EV+ P+F ++Q+ ++ ++L+ +GI  IF   A+L+ LS   + + +S+ + +
Sbjct: 281 NSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEIFIKDANLTGLS-DNKEIFLSKAIHK 339

Query: 386 TVIEVDERGTE--AVAGILSEITAYSMPPVIKVDRPFHFMIYEETSGMLLFLGRVVNP 441
           + +EV+E G+E  AV+G+++      + P + VD PF F+I    +G +LF+GRV++P
Sbjct: 340 SFLEVNEEGSEAAAVSGMIAISRMAVLYPQVIVDHPFFFLIRNRRTGTILFMGRVMHP 397


>gi|122937297 serpin peptidase inhibitor, clade A (alpha-1
           antiproteinase, antitrypsin), member 11 [Homo sapiens]
          Length = 422

 Score =  162 bits (410), Expect = 6e-40
 Identities = 107/369 (28%), Positives = 192/369 (52%), Gaps = 11/369 (2%)

Query: 80  SNFGFSLLRKISMRHDGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPG 139
           +NF   L ++++    GN+ FSP  +S  +  L LGA   T   I  GL    L  T   
Sbjct: 55  TNFALRLYKELAADAPGNIFFSPVSISTTLALLSLGAQANTSALILEGLGFN-LTETPEA 113

Query: 140 LLPSLFKGLRETLSR-NLELGLTQGSFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNA 198
            +   F+ L  TL+  + +L L  G+  F+ K    ++ + +  K  +       NF ++
Sbjct: 114 DIHQGFRSLLHTLALPSPKLELKVGNSLFLDKRLKPRQHYLDSIKELYGAFAFSANFTDS 173

Query: 199 SQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKGKWLTPFDPVFTE-VDTFH 257
               R +N Y+ ++T G++     E + +T ++L +YI FK KW  PF    T+  ++F 
Sbjct: 174 VTTGRQINDYLRRQTYGQVVDCLPEFSQDTFMVLANYIFFKAKWKHPFSRYQTQKQESFF 233

Query: 258 LDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLT 317
           +D+  +++VPMM+        +D++  C VL++ Y+GNA  L+VL +  G    +E  L 
Sbjct: 234 VDERTSLQVPMMHQKEMHRFLYDQDLACTVLQIEYRGNALALLVLPDP-GKMKQVEAALQ 292

Query: 318 TDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFSPFADLSELSATGR-N 376
              +  W + +    +++  P+F +   Y + ++L Q+G+  I +  AD S    TG+ N
Sbjct: 293 PQTLRKWGQLLLPSLLDLHLPRFSISGTYNLEDILPQIGLTNILNLEADFS--GVTGQLN 350

Query: 377 LQVSRVLQRTVIEVDERGTE--AVAGILSEITAYS--MPPVIKVDRPFHFMIYEETSGML 432
             +S+V  + ++++ E+GTE  A +G+LS+  + +    P    +RPF  +++E T+  L
Sbjct: 351 KTISKVSHKAMVDMSEKGTEAGAASGLLSQPPSLNTMSDPHAHFNRPFLLLLWEVTTQSL 410

Query: 433 LFLGRVVNP 441
           LFLG+VVNP
Sbjct: 411 LFLGKVVNP 419


>gi|4758906 serpin peptidase inhibitor, clade B, member 9 [Homo
           sapiens]
          Length = 376

 Score =  159 bits (403), Expect = 4e-39
 Identities = 119/380 (31%), Positives = 189/380 (49%), Gaps = 16/380 (4%)

Query: 73  QQLAKETSNFGFSLLRKISMRHDGNMVF-SPFGMSLAMTGLMLGATGPTETQIKRGLHLQ 131
           + L+  +  F   LL+ +   +  + VF SP  +S A+  ++LGA G T TQ+ + L L 
Sbjct: 2   ETLSNASGTFAIRLLKILCQDNPSHNVFCSPVSISSALAMVLLGAKGNTATQMAQALSLN 61

Query: 132 ALKPTKPGLLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKETFFNLSKRYFDTECV 191
               T+  +  +    L E      +  L   +  F  K      TF     +++  E  
Sbjct: 62  ----TEEDIHRAFQSLLTEVNKAGTQYLLRTANRLFGEKTCQFLSTFKESCLQFYHAELK 117

Query: 192 PMNF-RNASQAKRLMNHYINKETRGKIPKLF--DEINPETKLILVDYILFKGKWLTPFDP 248
            ++F R A ++++ +N +++K+T GKI +L     I+ ET+L+LV+ I FKGKW  PFD 
Sbjct: 118 ELSFIRAAEESRKHINTWVSKKTEGKIEELLPGSSIDAETRLVLVNAIYFKGKWNEPFDE 177

Query: 249 VFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLVVLMEKMGD 308
            +T    F +++ +   V MMY    F        R  +L+LPY      L+VL+   G 
Sbjct: 178 TYTREMPFKINQEEQRPVQMMYQEATFKLAHVGEVRAQLLELPYARKELSLLVLLPDDGV 237

Query: 309 HLA-LEDYLTTDLVETWLRN--MKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFSP-F 364
            L+ +E  LT + +  W +   MK+  +EV  PKFKL + Y+M  +LR +GI   F    
Sbjct: 238 ELSTVEKSLTFEKLTAWTKPDCMKSTEVEVLLPKFKLQEDYDMESVLRHLGIVDAFQQGK 297

Query: 365 ADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITA---YSMPPVIKVDRPFH 421
           ADLS +SA  R+L +S+ + ++ +EV+E GTEA A     + A       P    D PF 
Sbjct: 298 ADLSAMSAE-RDLCLSKFVHKSFVEVNEEGTEAAAASSCFVVAECCMESGPRFCADHPFL 356

Query: 422 FMIYEETSGMLLFLGRVVNP 441
           F I    +  +LF GR  +P
Sbjct: 357 FFIRHNRANSILFCGRFSSP 376


>gi|4502261 serpin peptidase inhibitor, clade C, member 1 [Homo
           sapiens]
          Length = 464

 Score =  158 bits (399), Expect = 1e-38
 Identities = 127/451 (28%), Positives = 210/451 (46%), Gaps = 24/451 (5%)

Query: 8   LLSVLLAQVWLVPGLAPSPQSPETPAPQN--QTSRVVQAPKEEEEDEQEASEEKASE--E 63
           LLS+LL   W       SP    T  P++       +    E++  E E SE+K  E   
Sbjct: 18  LLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATN 77

Query: 64  EKAWLMASRQQLAKETSNFGFSLLRKI--SMRHDGNMVFSPFGMSLAMTGLMLGATGPTE 121
            + W      +L+K  S F  +  + +  S   + N+  SP  +S A     LGA   T 
Sbjct: 78  RRVW------ELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTL 131

Query: 122 TQIKRGLHLQALKPTKPGLLPSLFKGLRETLSR--NLELGLTQGSFAFIHKDFDVKETFF 179
            Q+        +       +   F  L   L R  N    L   +  F  K     ET+ 
Sbjct: 132 QQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQ 191

Query: 180 NLSKRYFDTECVPMNFR-NASQAKRLMNHYINKETRGKIPKLF--DEINPETKLILVDYI 236
           ++S+  +  +  P++F+ NA Q++  +N +++ +T G+I  +   + IN  T L+LV+ I
Sbjct: 192 DISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTI 251

Query: 237 LFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNA 296
            FKG W + F P  T  + F+    ++    MMY  GKF           VL+LP++G+ 
Sbjct: 252 YFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAE-GTQVLELPFKGDD 310

Query: 297 TMLVVLMEKMGDHLA-LEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQM 355
             +V+++ K    LA +E  LT ++++ WL  ++   + V  P+F+++  + + E L+ M
Sbjct: 311 ITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDM 370

Query: 356 GIRRIFSP-FADLSELSATGR-NLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMPP- 412
           G+  +FSP  + L  + A GR +L VS    +  +EV+E G+EA A     I   S+ P 
Sbjct: 371 GLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPN 430

Query: 413 --VIKVDRPFHFMIYEETSGMLLFLGRVVNP 441
               K +RPF   I E     ++F+GRV NP
Sbjct: 431 RVTFKANRPFLVFIREVPLNTIIFMGRVANP 461


>gi|156071456 serpin peptidase inhibitor, clade B, member 11 [Homo
           sapiens]
          Length = 392

 Score =  154 bits (389), Expect = 2e-37
 Identities = 111/390 (28%), Positives = 200/390 (51%), Gaps = 30/390 (7%)

Query: 79  TSNFGFSL--LRKISMRHDG-NMVFSPFGMSLAMTGLMLGATGPTETQIKRGLH----LQ 131
           T+N  F L   ++++  + G N+ FS   +  A++ ++LGA G TE Q+++ LH    + 
Sbjct: 6   TANVEFCLDVFKELNSNNIGDNIFFSSLSLLYALSMVLLGARGETEEQLEKVLHFSHTVD 65

Query: 132 ALKP--------TKPGLLPSLFKGLRETLSR---NLELGLTQGSFAFIHKDFDVKETFFN 180
           +LKP        ++ G + S F      +++   N  L +    +    K     + + +
Sbjct: 66  SLKPGFKDSPKCSQAGRIHSEFGVEFSQINQPDSNCTLSIANRLYGT--KTMAFHQQYLS 123

Query: 181 LSKRYFDTECVPMNFRNASQ-AKRLMNHYINKETRGKIPKLFDE--INPETKLILVDYIL 237
            S++++      ++F  +++  ++ +N ++  +T GK+  LF +  I+P + ++LV+ I 
Sbjct: 124 CSEKWYQARLQTVDFEQSTEETRKTINAWVENKTNGKVANLFGKSTIDPSSVMVLVNAIY 183

Query: 238 FKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGN-A 296
           FKG+W   F    T    F L + K + V MMY  G F   F K  +  VL+LPY  N  
Sbjct: 184 FKGQWQNKFQVRETVKSPFQLSEGKNVTVEMMYQIGTFKLAFVKEPQMQVLELPYVNNKL 243

Query: 297 TMLVVLMEKMGDHLALEDYLTTDLVETWL--RNMKTRNMEVFFPKFKLDQKYEMHELLRQ 354
           +M+++L   + +   +E  L +     W    NM  R +EV  P+FKL+ KYE++ LL+ 
Sbjct: 244 SMIILLPVGIANLKQIEKQLNSGTFHEWTSSSNMMEREVEVHLPRFKLETKYELNSLLKS 303

Query: 355 MGIRRIFSPF-ADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAYSMP-- 411
           +G+  +F+   ADLS +S T + L +S+ + ++ ++V E GTEA A     I   S+P  
Sbjct: 304 LGVTDLFNQVKADLSGMSPT-KGLYLSKAIHKSYLDVSEEGTEAAAATGDSIAVKSLPMR 362

Query: 412 PVIKVDRPFHFMIYEETSGMLLFLGRVVNP 441
              K + PF F I    +  +LF G++ +P
Sbjct: 363 AQFKANHPFLFFIRHTHTNTILFCGKLASP 392


>gi|41152086 serine (or cysteine) proteinase inhibitor, clade B
           (ovalbumin), member 6 [Homo sapiens]
          Length = 376

 Score =  151 bits (382), Expect = 1e-36
 Identities = 110/380 (28%), Positives = 186/380 (48%), Gaps = 20/380 (5%)

Query: 75  LAKETSNFGFSLLRKISMRHDGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQALK 134
           LA+    F  +LL+ +   +  N+ FSP  MS A+  + +GA G T  Q+      Q L 
Sbjct: 4   LAEANGTFALNLLKTLGKDNSKNVFFSPMSMSCALAMVYMGAKGNTAAQMA-----QILS 58

Query: 135 PTKPGLLPSLFKGLRETLSRNLELG----LTQGSFAFIHKDFDVKETFFNLSKRYFDTEC 190
             K G    + +G +  L+   + G    L   +  F  K  D   +F +  ++++  E 
Sbjct: 59  FNKSGGGGDIHQGFQSLLTEVNKTGTQYLLRMANRLFGEKSCDFLSSFRDSCQKFYQAEM 118

Query: 191 VPMNFRNA-SQAKRLMNHYINKETRGKIPKLFD--EINPETKLILVDYILFKGKWLTPFD 247
             ++F +A  ++++ +N ++ ++T GKI +L     ++P T+L+LV+ + F+G W   FD
Sbjct: 119 EELDFISAVEKSRKHINTWVAEKTEGKIAELLSPGSVDPLTRLVLVNAVYFRGNWDEQFD 178

Query: 248 PVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQG-NATMLVVLMEKM 306
              TE   F + K +   V MM+    F  T+       +L LPY G    M+++L ++ 
Sbjct: 179 KENTEERLFKVSKNEEKPVQMMFKQSTFKKTYIGEIFTQILVLPYVGKELNMIIMLPDET 238

Query: 307 GDHLALEDYLTTDLVETWLR--NMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFS-P 363
            D   +E  LT +    W R   M    +EV  P+FKL++ Y+M  +LR +G+   F   
Sbjct: 239 TDLRTVEKELTYEKFVEWTRLDMMDEEEVEVSLPRFKLEESYDMESVLRNLGMTDAFELG 298

Query: 364 FADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVA--GILSEITAYSMPPVIKVDRPFH 421
            AD S +S T  +L +S+V+ ++ +EV+E GTEA A    +  +      P    D PF 
Sbjct: 299 KADFSGMSQT--DLSLSKVVHKSFVEVNEEGTEAAAATAAIMMMRCARFVPRFCADHPFL 356

Query: 422 FMIYEETSGMLLFLGRVVNP 441
           F I    +  +LF GR  +P
Sbjct: 357 FFIQHSKTNGILFCGRFSSP 376


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,251,439
Number of Sequences: 37866
Number of extensions: 745704
Number of successful extensions: 11254
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 183
Number of HSP's successfully gapped in prelim test: 73
Number of HSP's that attempted gapping in prelim test: 8955
Number of HSP's gapped (non-prelim): 1394
length of query: 444
length of database: 18,247,518
effective HSP length: 105
effective length of query: 339
effective length of database: 14,271,588
effective search space: 4838068332
effective search space used: 4838068332
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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