Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 148664248
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148664248 kelch domain containing 6 [Homo sapiens]
(623 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148664248 kelch domain containing 6 [Homo sapiens] 1272 0.0
gi|40807500 kelch-like 20 [Homo sapiens] 220 3e-57
gi|38194229 kelch-like 17 [Homo sapiens] 218 2e-56
gi|227497736 T-cell activation kelch repeat protein [Homo sapiens] 213 4e-55
gi|166235129 kelch-like 3 [Homo sapiens] 211 2e-54
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 206 7e-53
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 205 9e-53
gi|11056006 kelch-like 12 [Homo sapiens] 204 3e-52
gi|40018614 DRE1 protein [Homo sapiens] 202 6e-52
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 199 6e-51
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 199 6e-51
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 198 1e-50
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 198 1e-50
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 198 1e-50
gi|55925604 kelch-like 18 [Homo sapiens] 197 2e-50
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 195 1e-49
gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Hom... 193 3e-49
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 187 2e-47
gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Hom... 185 9e-47
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 183 4e-46
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 183 4e-46
gi|21359972 kelch repeat and BTB (POZ) domain containing 7 [Homo... 181 1e-45
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 179 7e-45
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 179 7e-45
gi|14780904 kelch-like 1 protein [Homo sapiens] 178 1e-44
gi|223890235 intracisternal A particle-promoted polypeptide isof... 176 4e-44
gi|34101268 kelch-like 8 [Homo sapiens] 174 2e-43
gi|8922854 kelch-like 26 [Homo sapiens] 174 3e-43
gi|156616301 kelch-like 32 [Homo sapiens] 170 3e-42
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 170 4e-42
>gi|148664248 kelch domain containing 6 [Homo sapiens]
Length = 623
Score = 1272 bits (3291), Expect = 0.0
Identities = 623/623 (100%), Positives = 623/623 (100%)
Query: 1 MECKIEGKEKYQHSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMF 60
MECKIEGKEKYQHSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMF
Sbjct: 1 MECKIEGKEKYQHSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMF 60
Query: 61 TCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVC 120
TCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVC
Sbjct: 61 TCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVC 120
Query: 121 QKYMMDHMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTL 180
QKYMMDHMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTL
Sbjct: 121 QKYMMDHMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTL 180
Query: 181 IKSDDLNISREESILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTML 240
IKSDDLNISREESILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTML
Sbjct: 181 IKSDDLNISREESILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTML 240
Query: 241 LCDADCVDIIQNAFKAIKTPQQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFC 300
LCDADCVDIIQNAFKAIKTPQQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFC
Sbjct: 241 LCDADCVDIIQNAFKAIKTPQQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFC 300
Query: 301 YDPVSRKTYFISSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHD 360
YDPVSRKTYFISSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHD
Sbjct: 301 YDPVSRKTYFISSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHD 360
Query: 361 RGNQFWEKLCTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVS 420
RGNQFWEKLCTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVS
Sbjct: 361 RGNQFWEKLCTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVS 420
Query: 421 PLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKY 480
PLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKY
Sbjct: 421 PLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKY 480
Query: 481 SKYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSL 540
SKYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSL
Sbjct: 481 SKYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSL 540
Query: 541 RTNSTNAGAVDGKLYVCGGFHGADRHEVISKEILELDPWENQWNVVAINVLMHDSYDVCL 600
RTNSTNAGAVDGKLYVCGGFHGADRHEVISKEILELDPWENQWNVVAINVLMHDSYDVCL
Sbjct: 541 RTNSTNAGAVDGKLYVCGGFHGADRHEVISKEILELDPWENQWNVVAINVLMHDSYDVCL 600
Query: 601 VARMNPRDLIPPPSDLVEEGNEH 623
VARMNPRDLIPPPSDLVEEGNEH
Sbjct: 601 VARMNPRDLIPPPSDLVEEGNEH 623
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 220 bits (561), Expect = 3e-57
Identities = 162/586 (27%), Positives = 272/586 (46%), Gaps = 63/586 (10%)
Query: 12 QHSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQRE 71
+H L I +++ E+ DVVL +K HR++L+A SPYF+AMFT L E Q E
Sbjct: 49 KHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTE 108
Query: 72 VILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDAS 131
V++ DI ++ +L+++ Y + + + NVQT+ AA +Q+ E+ C +++ +D S
Sbjct: 109 VVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPS 168
Query: 132 NCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISRE 191
NCLGI FA +L + K+ +F EV EE + + +Q + +I SD+LN+ E
Sbjct: 169 NCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSE 228
Query: 192 ESILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQ 251
E + + V+ WV ++ + R L ++L+ VRL L++P FL + + ++ D +C D++
Sbjct: 229 EQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVD 288
Query: 252 NAFKAIKTPQQHSL------NLRYGMETTSLLLCIGNNSSG--IRSRHRSYGDASFCYDP 303
A + PQ+ L R + +L +G SG I S R YDP
Sbjct: 289 EAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVER--------YDP 340
Query: 304 VSRKTYFISS-PKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHDRG 362
+ + ++S K G+G V+++ V G +S L+ + RY +
Sbjct: 341 QTNEWRMVASMSKRRCGVGV----SVLDDLLYAVGGHDGSSYLN-------SVERYDPKT 389
Query: 363 NQFWEKLC-TAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSP 421
NQ+ + T+ R + + LY +GGQ + N V++Y + + W RV+
Sbjct: 390 NQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVS----CLNIVERYDPKENKWTRVAS 445
Query: 422 LPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYS 481
+ + AV + LY +GG L N + +Y+P +++W APM
Sbjct: 446 MSTRRLGVAVAVLGGFLYAVGGSDGTSPL---------NTVERYNPQENRWHTIAPMGTR 496
Query: 482 KYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLR 541
+ AV IY +GG + L E YNP + W SP++++
Sbjct: 497 RKHLGCAVYQDMIYAVGGRDDTTE--------LSSAERYNPRTNQW-------SPVVAMT 541
Query: 542 TNSTNAG--AVDGKLYVCGGFHGADRHEVISKEILELDPWENQWNV 585
+ + G V+G+L GGF G K I DP N W +
Sbjct: 542 SRRSGVGLAVVNGQLMAVGGFDGT----TYLKTIEVFDPDANTWRL 583
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 218 bits (554), Expect = 2e-56
Identities = 164/599 (27%), Positives = 262/599 (43%), Gaps = 54/599 (9%)
Query: 21 IQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAE 80
+ M++ + D+VL ++ H++VLA+ SPYF AMFT + E Q V L+DI +
Sbjct: 82 MSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQ 141
Query: 81 SVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGIYYFA 140
++ L+ + Y A + + NVQT+ AA +Q+ V C K+++ +D SNCLGI FA
Sbjct: 142 ALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFA 201
Query: 141 KQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLR 200
DL + +Y+ QHF +V+ EE + + + Q L L+ SD LN+ EE + VL
Sbjct: 202 DAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLS 261
Query: 201 WVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQNAFKAIKTP 260
WV H+ + R H+ L+K VRL L++ FL + +++ DC D++ A K P
Sbjct: 262 WVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLP 321
Query: 261 QQHSLNLRYGMETTSLLLCIGNN----SSGIRSRHRSYGDASFCYDPVSRKTYFISSPKY 316
+Q + G T C G + G S +GD YD + + + ++S
Sbjct: 322 EQRGV---LGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCE-AYDTRTDRWHVVASMST 377
Query: 317 GEG-LGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEKLCTAEFR 375
+G G N V G S L+ + Y N + ++ R
Sbjct: 378 RRARVGVAAVG----NRLYAVGGYDGTSDLA-------TVESYDPVTNTWQPEVSMGTRR 426
Query: 376 ELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVN 435
+ ++H LY GG + N ++Y W V+ + + V T++
Sbjct: 427 SCLGVAALHGLLYSAGGY----DGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLD 482
Query: 436 NKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIY 495
LY +GG+ L E +Y+P + WS A M + AV+ +Y
Sbjct: 483 GNLYAVGGYDSSSHLATVE---------KYEPQVNVWSPVASMLSRRSSAGVAVLEGALY 533
Query: 496 VLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGAVDGKLY 555
V GG CL+ VE Y+P W PM ++R ++ + A+DG LY
Sbjct: 534 VAGG--------NDGTSCLNSVERYSPKAGAWESVAPM-----NIRRSTHDLVAMDGWLY 580
Query: 556 VCGGFHGADRHEVISKEILELDPWENQWNVVAINVLMHDSYDVCLVARMNPRDLIPPPS 614
GG G+ I K +P N+W + S V ++ +N PPPS
Sbjct: 581 AVGGNDGSSSLNSIEK----YNPRTNKWVAASCMFTRRSSVGVAVLELLN----FPPPS 631
>gi|227497736 T-cell activation kelch repeat protein [Homo sapiens]
Length = 601
Score = 213 bits (542), Expect = 4e-55
Identities = 137/491 (27%), Positives = 233/491 (47%), Gaps = 37/491 (7%)
Query: 13 HSLNLLNKIQNMKELAEMIDVVLTAE-GEKFPCHRLVLAAFSPYFKAMFTCGLLECNQRE 71
H+ ++L +++ M + ++ D+V+ + G+ F CHR VLAA SPYF++MFT GL E Q+E
Sbjct: 31 HACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKE 90
Query: 72 VILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDAS 131
V + + AES+ ++LNY Y + + + ANVQ + AA Q+ + C KYM+ H+D
Sbjct: 91 VRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQ 150
Query: 132 NCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISRE 191
N +G++ FA G ++L DRSK+Y+ + F V+ +E L++ Q ++++ SDDLN+ RE
Sbjct: 151 NSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDRE 210
Query: 192 ESILDLVLRWVNHNKELRTVHLVELL-KQVRLELVNPSFLRQALRRNTMLLCDADCVDII 250
E + + ++RW H + R VHL E+ K +R L+ +F+ + + + + CV+
Sbjct: 211 EHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKS-CVE-- 267
Query: 251 QNAFKAIKTPQQ-HSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSRKTY 309
K P + R GM + +++C +H C D V+ + +
Sbjct: 268 -------KGPSNTNGCTQRLGMTASEMIICF-----DAAHKHSGKKQTVPCLDIVTGRVF 315
Query: 310 FISSPKYGEGLGTVCTGVVMENNTIIVAG-EASASKLSRQKNKNVEIYRYHDRGNQFWEK 368
+ P L V V +N+ I G S+S++S + + Y N++ K
Sbjct: 316 KLCKPP--NDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSK 373
Query: 369 LCTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLAC 428
R L +Y IGG++ + V+ Y + W V +P+ +
Sbjct: 374 PSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEF 433
Query: 429 HAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTA 488
H V K+YV+ G L Y+P +D W PM + + A
Sbjct: 434 HNAVEYKEKIYVLQG----------------EFFLFYEPQKDYWGFLTPMTVPRIQGLAA 477
Query: 489 VVNSEIYVLGG 499
V IY + G
Sbjct: 478 VYKDSIYYIAG 488
Score = 36.6 bits (83), Expect = 0.071
Identities = 33/125 (26%), Positives = 56/125 (44%), Gaps = 11/125 (8%)
Query: 354 EIYRYHDRGNQFWEKLCTAEFRELYALGSIHND-LYVIGGQMKIKNQYLITNCVDKYSVE 412
E + +++ +W L + L +++ D +Y I G +Q + T V+ Y +E
Sbjct: 449 EFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCG-NHQRMFT--VEAYDIE 505
Query: 413 RDNWKRVSPLPLQLACHA---VVTVNNKLYVIGGWTPQMDLPDEEPDRLS--NKLLQYDP 467
+ W R P + + +V NKL++ T Q+ + +E R S N L QYD
Sbjct: 506 LNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRAT-QVTV-EEHVFRTSRKNSLYQYDD 563
Query: 468 SQDQW 472
DQW
Sbjct: 564 IADQW 568
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 211 bits (536), Expect = 2e-54
Identities = 155/589 (26%), Positives = 257/589 (43%), Gaps = 90/589 (15%)
Query: 14 SLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVI 73
+ ++N++++ + L DV++ AE + HR+VLAA SPYF AMFT + E +++
Sbjct: 36 AFKVMNELRSKQLLC---DVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIE 92
Query: 74 LYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNC 133
+ D+ +++S L++Y+Y A +E+ NVQ + AA +Q+ +V C ++ + +NC
Sbjct: 93 IKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNC 152
Query: 134 LGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREES 193
LGI FA DL ++ Y QHF EV L EE L + + Q +LI SD L +S EE
Sbjct: 153 LGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEK 212
Query: 194 ILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQNA 253
+ + V+ W+N+ KE R H+ +L++ VRL L+ +L Q + ++ + C D + A
Sbjct: 213 VFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEA 272
Query: 254 FKAIKTPQQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSRKTYFISS 313
K P L ++ +P ++ +S
Sbjct: 273 MKYHLLPLDQRLLIK---------------------------------NPRTKPRTPVSL 299
Query: 314 PKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEKLCTAE 373
PK I+V G+A + ++VE Y + + W+++
Sbjct: 300 PKV----------------MIVVGGQAPKAI------RSVECYDFEE---DRWDQIAELP 334
Query: 374 FRELYA-LGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVV 432
R A + + +Y +GG N L VD Y +D W ++ + + +
Sbjct: 335 SRRCRAGVVFMAGHVYAVGGF----NGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAA 390
Query: 433 TVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNS 492
+N+ LY +GG+ L E Y ++W APM + VV
Sbjct: 391 VLNDLLYAVGGFDGSTGLASVEA---------YSYKTNEWFFVAPMNTRRSSVGVGVVEG 441
Query: 493 EIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGAVDG 552
++Y +GG G R+CL VE YNP + W M S R + G + G
Sbjct: 442 KLYAVGGYD------GASRQCLSTVEQYNPATNEWIYVADM-----STRRSGAGVGVLSG 490
Query: 553 KLYVCGGFHGADRHEVISKEILELDPWENQWNVVAINVLMHDSYDVCLV 601
+LY GG G ++ K + DP N W VA + + VC V
Sbjct: 491 QLYATGGHDG----PLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAV 535
Score = 52.0 bits (123), Expect = 2e-06
Identities = 45/176 (25%), Positives = 71/176 (40%), Gaps = 21/176 (11%)
Query: 352 NVEIYRYHDRGNQFWEKLCTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSV 411
+VE Y Y + N+++ R +G + LY +GG Q L T V++Y+
Sbjct: 410 SVEAYSY--KTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLST--VEQYNP 465
Query: 412 ERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQ 471
+ W V+ + + + V ++ +LY GG + + + YDP +
Sbjct: 466 ATNEWIYVADMSTRRSGAGVGVLSGQLYATGG---------HDGPLVRKSVEVYDPGTNT 516
Query: 472 WSVRAPMKYSKYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFW 527
W A M + VN +YV+GG D G L VE YNP D W
Sbjct: 517 WKQVADMNMCRRNAGVCAVNGLLYVVGG------DDGSCN--LASVEYYNPVTDKW 564
Score = 38.9 bits (89), Expect = 0.014
Identities = 38/147 (25%), Positives = 60/147 (40%), Gaps = 18/147 (12%)
Query: 328 VMENNTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEKLCTAEFRELYALGSIHNDL 387
V+E V G AS RQ VE +Y+ N++ + R +G + L
Sbjct: 438 VVEGKLYAVGGYDGAS---RQCLSTVE--QYNPATNEWIYVADMSTRRSGAGVGVLSGQL 492
Query: 388 YVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQ 447
Y GG + L+ V+ Y + WK+V+ + + V VN LYV+GG
Sbjct: 493 YATGGH----DGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGS 548
Query: 448 MDLPDEEPDRLSNKLLQYDPSQDQWSV 474
+L E Y+P D+W++
Sbjct: 549 CNLASVE---------YYNPVTDKWTL 566
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 206 bits (523), Expect = 7e-53
Identities = 154/584 (26%), Positives = 261/584 (44%), Gaps = 48/584 (8%)
Query: 13 HSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREV 72
H+ L K++N + ++ DV+L A + P HRLVL+A S YF AMFT +LE Q EV
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
Query: 73 ILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASN 132
+ + +++ L+ Y Y L++ ++++ AA +Q+ +V VC +++ + SN
Sbjct: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
Query: 133 CLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREE 192
CLGI F G +L + + KY +HF EV ++E L + ++ L+ SDD+N+ EE
Sbjct: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
Query: 193 SILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQN 252
+I +++WV H+ + R L LL +RL L+ P L L ++M D +C ++
Sbjct: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLME 402
Query: 253 AFKAIKTPQQHSL----NLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSRKT 308
A K P++ S+ + T L +G + G + + +
Sbjct: 403 AMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDA-------MKGTTTIEKYDLRTNS 455
Query: 309 YFISSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEK 368
+ G L GV + +N + V G R K + + + W
Sbjct: 456 WLHIGTMNGRRLQ---FGVAVIDNKLYVVG-------GRDGLKTLNTVECFNPVGKIWTV 505
Query: 369 L-CTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLA 427
+ + R + ++ +Y +GG + + N V+++ E W V+ + +
Sbjct: 506 MPPMSTHRHGLGVATLEGPMYAVGGH----DGWSYLNTVERWDPEGRQWNYVASMSTPRS 561
Query: 428 CHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFST 487
VV +NNKLY IGG L E +DP ++WS+ APM +
Sbjct: 562 TVGVVALNNKLYAIGGRDGSSCLKSME---------YFDPHTNKWSLCAPMSKRRGGVGV 612
Query: 488 AVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNA 547
A N +YV+GG + + D VE Y+P GD W P LS+ ++
Sbjct: 613 ATYNGFLYVVGGHDAPASN--HCSRLSDCVERYDPKGDSWSTVAP-----LSVPRDAVAV 665
Query: 548 GAVDGKLYVCGGFHGADRHEVISKEILELDPWENQW-NVVAINV 590
+ KLYV GG+ G H ++ + D N+W V +N+
Sbjct: 666 CPLGDKLYVVGGYDG---HTYLN-TVESYDAQRNEWKEEVPVNI 705
Score = 56.6 bits (135), Expect = 7e-08
Identities = 46/194 (23%), Positives = 81/194 (41%), Gaps = 25/194 (12%)
Query: 301 YDPVSRKTYFISSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHD 360
+DP R+ +++S GVV NN + G R + ++ Y D
Sbjct: 543 WDPEGRQWNYVASMSTPRST----VGVVALNNKLYAIG-------GRDGSSCLKSMEYFD 591
Query: 361 RGNQFWEKLCTAEFRELYALG--SIHNDLYVIGGQMKIKNQYL--ITNCVDKYSVERDNW 416
W LC + +G + + LYV+GG + + +++CV++Y + D+W
Sbjct: 592 PHTNKWS-LCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSW 650
Query: 417 KRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRA 476
V+PL + AV + +KLYV+GG+ L N + YD +++W
Sbjct: 651 STVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYL---------NTVESYDAQRNEWKEEV 701
Query: 477 PMKYSKYRFSTAVV 490
P+ + VV
Sbjct: 702 PVNIGRAGACVVVV 715
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 205 bits (522), Expect = 9e-53
Identities = 152/576 (26%), Positives = 257/576 (44%), Gaps = 47/576 (8%)
Query: 13 HSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREV 72
H+ L K++N + ++ DV+L A + P HRLVL+A S YF AMFT +LE Q EV
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
Query: 73 ILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASN 132
+ + +++ L+ Y Y L++ ++++ AA +Q+ +V VC +++ + SN
Sbjct: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
Query: 133 CLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREE 192
CLGI F G +L + + KY +HF EV ++E L + ++ L+ SDD+N+ EE
Sbjct: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
Query: 193 SILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQN 252
+I +++WV H+ + R L LL +RL L+ P L L ++M D +C ++
Sbjct: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLME 402
Query: 253 AFKAIKTPQQHSL----NLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSRKT 308
A K P++ S+ + T L +G + G + + +
Sbjct: 403 AMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDA-------MKGTTTIEKYDLRTNS 455
Query: 309 YFISSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEK 368
+ G L GV + +N + V G R K + + + W
Sbjct: 456 WLHIGTMNGRRLQ---FGVAVIDNKLYVVG-------GRDGLKTLNTVECFNPVGKIWTV 505
Query: 369 L-CTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLA 427
+ + R + ++ +Y +GG + + N V+++ E W V+ + +
Sbjct: 506 MPPMSTHRHGLGVATLEGPMYAVGGH----DGWSYLNTVERWDPEGRQWNYVASMSTPRS 561
Query: 428 CHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFST 487
VV +NNKLY IGG L E +DP ++WS+ APM +
Sbjct: 562 TVGVVALNNKLYAIGGRDGSSCLKSME---------YFDPHTNKWSLCAPMSKRRGGVGV 612
Query: 488 AVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNA 547
A N +YV+GG + + D VE Y+P GD W P LS+ ++
Sbjct: 613 ATYNGFLYVVGGHDAPASN--HCSRLSDCVERYDPKGDSWSTVAP-----LSVPRDAVAV 665
Query: 548 GAVDGKLYVCGGFHGADRHEVISKEILELDPWENQW 583
+ KLYV GG+ G H ++ + D N+W
Sbjct: 666 CPLGDKLYVVGGYDG---HTYLN-TVESYDAQRNEW 697
Score = 65.9 bits (159), Expect = 1e-10
Identities = 48/201 (23%), Positives = 86/201 (42%), Gaps = 30/201 (14%)
Query: 387 LYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTP 446
LY +GG +K T ++KY + ++W + + + V ++NKLYV+GG
Sbjct: 431 LYAVGGMDAMKG----TTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGG--- 483
Query: 447 QMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGIGCVGQD 506
+ + N + ++P W+V PM ++ A + +Y +GG
Sbjct: 484 ------RDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGG------- 530
Query: 507 KGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGAVDGKLYVCGGFHGADRH 566
L+ VE ++P+G W M +P ++ A++ KLY GG G+
Sbjct: 531 -HDGWSYLNTVERWDPEGRQWNYVASMSTP-----RSTVGVVALNNKLYAIGGRDGSS-- 582
Query: 567 EVISKEILELDPWENQWNVVA 587
K + DP N+W++ A
Sbjct: 583 --CLKSMEYFDPHTNKWSLCA 601
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 204 bits (518), Expect = 3e-52
Identities = 151/593 (25%), Positives = 254/593 (42%), Gaps = 46/593 (7%)
Query: 13 HSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREV 72
H+ ++LN + ++++ + DV L E + FP HR+VLAA S YF AMFT L E + V
Sbjct: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
Query: 73 ILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASN 132
+ +TA ++ +LL+++Y + + NVQ + AA +Q++ V C +++ +D SN
Sbjct: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
Query: 133 CLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREE 192
CLGI FA+ DL ++ + +HF EV HEE + + + LIK D++ + EE
Sbjct: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194
Query: 193 SILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQN 252
+ + V+ WV H K+ R L LL+ VR+ L+ P ++ + + C C D++
Sbjct: 195 PVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDE 254
Query: 253 AFKAIKTP----QQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSRKT 308
A K P Q R + +LL +G S +S D YDP +++
Sbjct: 255 AKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGS-----QQSPIDVVEKYDPKTQEW 309
Query: 309 YFISSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEK 368
F+ S V + + ++ G S+LS +VE Y + W
Sbjct: 310 SFLPSITRKR---RYVASVSLHDRIYVIGGYDGRSRLS-----SVECLDYTADEDGVWYS 361
Query: 369 LCTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLAC 428
+ R A + D+ + G ++ +++Y D W + +
Sbjct: 362 VAPMNVRRGLAGATTLGDMIYVSGGFDGSRRH---TSMERYDPNIDQWSMLGDMQTAREG 418
Query: 429 HAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTA 488
+V + +Y +GG+ + + N + +YDP W+ PM + A
Sbjct: 419 AGLVVASGVIYCLGGY---------DGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVA 469
Query: 489 VVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAG 548
++N IYV+GG L VE YN D W M +P + A
Sbjct: 470 LLNDHIYVVGGFDGTAH--------LSSVEAYNIRTDSWTTVTSMTTPRCYV-----GAT 516
Query: 549 AVDGKLYVCGGFHGADRHEVISKEILELDPWENQWNVVAINVLMHDSYDVCLV 601
+ G+LY G+ G + I DP + W VV VC++
Sbjct: 517 VLRGRLYAIAGYDG----NSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVL 565
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 202 bits (515), Expect = 6e-52
Identities = 150/550 (27%), Positives = 258/550 (46%), Gaps = 49/550 (8%)
Query: 13 HSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREV 72
H+ N+L ++ DV++ EG++FPCHR VL+A S YF+AMF E + V
Sbjct: 48 HAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLV 107
Query: 73 ILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASN 132
+ I AE++ L Y+Y ++I NVQ + + Q+ + C K++ + +D N
Sbjct: 108 EINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCN 167
Query: 133 CLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREE 192
CLGI FA + L + K + Q F +VS HEE LE++ + + I SD+L I +EE
Sbjct: 168 CLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEE 227
Query: 193 SILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQN 252
+ + V+RWV +LR L ELL VRL L++P++ Q + + ++ +C ++
Sbjct: 228 MVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHE 287
Query: 253 AFK-AIKTPQQHSLNLRYGMET-TSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSRKTYF 310
A + I + S R T S ++ + + + Y + CYDPV+ +
Sbjct: 288 ARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTE---CYDPVTGEWKS 344
Query: 311 ISS-PKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEKL 369
++ P++ + VC N I+V+G S+ +++ Y+ + N +
Sbjct: 345 LAKLPEFTKSEYAVCA----LRNDILVSGGRINSR---------DVWIYNSQLNIWIRVA 391
Query: 370 CTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACH 429
+ R + + + +YV+GG +N+ C D +S + W V+PL ++
Sbjct: 392 SLNKGRWRHKMAVLLGKVYVVGG-YDGQNRLSSVECYDSFS---NRWTEVAPLKEAVSSP 447
Query: 430 AVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAV 489
AV + KL+VIGG PD+ + S+K+ YDP + W +RA + +K +
Sbjct: 448 AVTSCVGKLFVIGGG------PDD--NTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVS 499
Query: 490 VNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGA 549
+N+ IYV GG+ + Y+P D+W M R +
Sbjct: 500 LNNLIYVAGGL-------------TKAIYCYDPVEDYW-----MHVQNTFSRQENCGMSV 541
Query: 550 VDGKLYVCGG 559
+GK+Y+ GG
Sbjct: 542 CNGKIYILGG 551
Score = 34.3 bits (77), Expect = 0.35
Identities = 33/131 (25%), Positives = 52/131 (39%), Gaps = 35/131 (26%)
Query: 465 YDPSQDQWSVRAPM-KYSKYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPD 523
YDP +W A + +++K ++ + ++I V GG R V IYN
Sbjct: 335 YDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGG-----------RINSRDVWIYNSQ 383
Query: 524 GDFWREGPPMPSPLLSLRTNSTNAG-------AVDGKLYVCGGFHGADRHEVISKEILEL 576
+ W +R S N G + GK+YV GG+ G +R +
Sbjct: 384 LNIW------------IRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVEC----Y 427
Query: 577 DPWENQWNVVA 587
D + N+W VA
Sbjct: 428 DSFSNRWTEVA 438
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 199 bits (506), Expect = 6e-51
Identities = 151/590 (25%), Positives = 255/590 (43%), Gaps = 92/590 (15%)
Query: 14 SLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVI 73
+ ++N++++ L DV + AE + HR+VLAA SPYF AMFT + E + V
Sbjct: 46 AFKVMNELRSQNLLC---DVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVR 102
Query: 74 LYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNC 133
+ ++ ++ +L++Y+Y A +++ NVQ + AA +Q+++V C +++ + NC
Sbjct: 103 IKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNC 162
Query: 134 LGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREES 193
LGI FA DL +++ Y QHFA+V L EE L + + Q +LI SD L IS EE
Sbjct: 163 LGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEK 222
Query: 194 ILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQNA 253
+ + V+ WVNH+K++R + L++ VRL L+ +L Q + ++ + C D + A
Sbjct: 223 VFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEA 282
Query: 254 FKAIKTPQQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSRKTYFISS 313
K P + + ++ +R+R R
Sbjct: 283 MKYHLLPTEQRILMK-----------------SVRTRLR--------------------- 304
Query: 314 PKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEKLCTAE 373
T + + ++V G+A + ++VE Y + + + W ++
Sbjct: 305 -----------TPMNLPKLMVVVGGQAP------KAIRSVECYDFKE---ERWHQVAELP 344
Query: 374 FRELYALGSIH--NDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAV 431
R A G ++ ++ +GG N L VD Y +D W V+ + + +
Sbjct: 345 SRRCRA-GMVYMAGLVFAVGG----FNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGA 399
Query: 432 VTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVN 491
+N LY +GG+ L E Y+ ++W APM + VV
Sbjct: 400 AVLNGLLYAVGGFDGSTGLSSVE---------AYNIKSNEWFHVAPMNTRRSSVGVGVVG 450
Query: 492 SEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGAVD 551
+Y +GG G R+CL VE YN + W M S R + G ++
Sbjct: 451 GLLYAVGGY------DGASRQCLSTVECYNATTNEWTYIAEM-----STRRSGAGVGVLN 499
Query: 552 GKLYVCGGFHGADRHEVISKEILELDPWENQWNVVAINVLMHDSYDVCLV 601
LY GG G ++ K + DP N W VA + + VC V
Sbjct: 500 NLLYAVGGHDG----PLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAV 545
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 199 bits (506), Expect = 6e-51
Identities = 151/590 (25%), Positives = 255/590 (43%), Gaps = 92/590 (15%)
Query: 14 SLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVI 73
+ ++N++++ L DV + AE + HR+VLAA SPYF AMFT + E + V
Sbjct: 42 AFKVMNELRSQNLLC---DVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVR 98
Query: 74 LYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNC 133
+ ++ ++ +L++Y+Y A +++ NVQ + AA +Q+++V C +++ + NC
Sbjct: 99 IKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNC 158
Query: 134 LGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREES 193
LGI FA DL +++ Y QHFA+V L EE L + + Q +LI SD L IS EE
Sbjct: 159 LGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEK 218
Query: 194 ILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQNA 253
+ + V+ WVNH+K++R + L++ VRL L+ +L Q + ++ + C D + A
Sbjct: 219 VFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEA 278
Query: 254 FKAIKTPQQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSRKTYFISS 313
K P + + ++ +R+R R
Sbjct: 279 MKYHLLPTEQRILMK-----------------SVRTRLR--------------------- 300
Query: 314 PKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEKLCTAE 373
T + + ++V G+A + ++VE Y + + + W ++
Sbjct: 301 -----------TPMNLPKLMVVVGGQAP------KAIRSVECYDFKE---ERWHQVAELP 340
Query: 374 FRELYALGSIH--NDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAV 431
R A G ++ ++ +GG N L VD Y +D W V+ + + +
Sbjct: 341 SRRCRA-GMVYMAGLVFAVGG----FNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGA 395
Query: 432 VTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVN 491
+N LY +GG+ L E Y+ ++W APM + VV
Sbjct: 396 AVLNGLLYAVGGFDGSTGLSSVE---------AYNIKSNEWFHVAPMNTRRSSVGVGVVG 446
Query: 492 SEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGAVD 551
+Y +GG G R+CL VE YN + W M S R + G ++
Sbjct: 447 GLLYAVGGY------DGASRQCLSTVECYNATTNEWTYIAEM-----STRRSGAGVGVLN 495
Query: 552 GKLYVCGGFHGADRHEVISKEILELDPWENQWNVVAINVLMHDSYDVCLV 601
LY GG G ++ K + DP N W VA + + VC V
Sbjct: 496 NLLYAVGGHDG----PLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAV 541
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 198 bits (503), Expect = 1e-50
Identities = 149/581 (25%), Positives = 250/581 (43%), Gaps = 49/581 (8%)
Query: 13 HSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREV 72
H+ K++N ++ DV+L A + P HRLVL++ S YF AMFT + E Q E+
Sbjct: 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI 215
Query: 73 ILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASN 132
+ + S+ L+ Y Y LE+ N++ + A +Q+ +V C K++M + SN
Sbjct: 216 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 275
Query: 133 CLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREE 192
CLGI FA G DL + Y +HF EV ++E + + + L+ SDD+NI EE
Sbjct: 276 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEE 335
Query: 193 SILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQN 252
+IL+ +L WV H+ E R L +LL +RL L+ P FL + N + D +C +I
Sbjct: 336 TILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIME 394
Query: 253 AFK----AIKTPQQHSLNLRYGMETTSLLLCIG--NNSSGIRSRHRSYGDASFCYDPVSR 306
A K + P S + T L +G +++ G S + Y + + PV+
Sbjct: 395 AMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEK-YDLRTNMWTPVAN 453
Query: 307 KTYFISSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFW 366
++ + G+ V+++ +V G L+ VE Y +
Sbjct: 454 ----MNGRRLQFGV------AVLDDKLYVVGGRDGLKTLN-----TVECYNPKTKTWSVM 498
Query: 367 EKLCTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQL 426
+ T R + + +Y +GG + + N V+++ + W V+ +
Sbjct: 499 PPMST--HRHGLGVAVLEGPMYAVGGH----DGWSYLNTVERWDPQARQWNFVATMSTPR 552
Query: 427 ACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFS 486
+ V ++ KLY +GG L E +DP ++W++ A M +
Sbjct: 553 STVGVAVLSGKLYAVGGRDGSSCLKSVE---------CFDPHTNKWTLCAQMSKRRGGVG 603
Query: 487 TAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTN 546
N +Y +GG + + D VE Y+P D W M S+ ++
Sbjct: 604 VTTWNGLLYAIGGHDAPASN--LTSRLSDCVERYDPKTDMWTAVASM-----SISRDAVG 656
Query: 547 AGAVDGKLYVCGGFHGADRHEVISKEILELDPWENQWNVVA 587
+ KLY GG+ G + + DP N+W VA
Sbjct: 657 VCLLGDKLYAVGGYDG----QAYLNTVEAYDPQTNEWTQVA 693
Score = 47.8 bits (112), Expect = 3e-05
Identities = 46/185 (24%), Positives = 80/185 (43%), Gaps = 31/185 (16%)
Query: 301 YDPVSRKTYFI---SSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYR 357
+DP +R+ F+ S+P+ G+ V+ V G +S L K+VE +
Sbjct: 535 WDPQARQWNFVATMSTPRSTVGVA------VLSGKLYAVGGRDGSSCL-----KSVECFD 583
Query: 358 YHDRGNQFWEKLCTAEFRELYALG--SIHNDLYVIGGQMKIKNQYL--ITNCVDKYSVER 413
H W LC + +G + + LY IGG + +++CV++Y +
Sbjct: 584 PHTNK---WT-LCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKT 639
Query: 414 DNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWS 473
D W V+ + + V + +KLY +GG+ Q L N + YDP ++W+
Sbjct: 640 DMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYL---------NTVEAYDPQTNEWT 690
Query: 474 VRAPM 478
AP+
Sbjct: 691 QVAPL 695
Score = 37.4 bits (85), Expect = 0.042
Identities = 36/138 (26%), Positives = 57/138 (41%), Gaps = 14/138 (10%)
Query: 300 CYDPVSRKTYFISSPKYGEGLGTVCTGVVMENNTIIVAG--EASASKLSRQKNKNVEIYR 357
C+DP + K + G GV N + G +A AS L+ + + VE Y
Sbjct: 581 CFDPHTNKWTLCAQMSKRRG----GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERY- 635
Query: 358 YHDRGNQFWEKLCTAEF-RELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNW 416
D W + + R+ + + + LY +GG + N V+ Y + + W
Sbjct: 636 --DPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGY----DGQAYLNTVEAYDPQTNEW 689
Query: 417 KRVSPLPLQLACHAVVTV 434
+V+PL L A VVTV
Sbjct: 690 TQVAPLCLGRAGACVVTV 707
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 198 bits (503), Expect = 1e-50
Identities = 149/581 (25%), Positives = 250/581 (43%), Gaps = 49/581 (8%)
Query: 13 HSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREV 72
H+ K++N ++ DV+L A + P HRLVL++ S YF AMFT + E Q E+
Sbjct: 202 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI 261
Query: 73 ILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASN 132
+ + S+ L+ Y Y LE+ N++ + A +Q+ +V C K++M + SN
Sbjct: 262 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 321
Query: 133 CLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREE 192
CLGI FA G DL + Y +HF EV ++E + + + L+ SDD+NI EE
Sbjct: 322 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEE 381
Query: 193 SILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQN 252
+IL+ +L WV H+ E R L +LL +RL L+ P FL + N + D +C +I
Sbjct: 382 TILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIME 440
Query: 253 AFK----AIKTPQQHSLNLRYGMETTSLLLCIG--NNSSGIRSRHRSYGDASFCYDPVSR 306
A K + P S + T L +G +++ G S + Y + + PV+
Sbjct: 441 AMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEK-YDLRTNMWTPVAN 499
Query: 307 KTYFISSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFW 366
++ + G+ V+++ +V G L+ VE Y +
Sbjct: 500 ----MNGRRLQFGV------AVLDDKLYVVGGRDGLKTLN-----TVECYNPKTKTWSVM 544
Query: 367 EKLCTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQL 426
+ T R + + +Y +GG + + N V+++ + W V+ +
Sbjct: 545 PPMST--HRHGLGVAVLEGPMYAVGGH----DGWSYLNTVERWDPQARQWNFVATMSTPR 598
Query: 427 ACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFS 486
+ V ++ KLY +GG L E +DP ++W++ A M +
Sbjct: 599 STVGVAVLSGKLYAVGGRDGSSCLKSVE---------CFDPHTNKWTLCAQMSKRRGGVG 649
Query: 487 TAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTN 546
N +Y +GG + + D VE Y+P D W M S+ ++
Sbjct: 650 VTTWNGLLYAIGGHDAPASN--LTSRLSDCVERYDPKTDMWTAVASM-----SISRDAVG 702
Query: 547 AGAVDGKLYVCGGFHGADRHEVISKEILELDPWENQWNVVA 587
+ KLY GG+ G + + DP N+W VA
Sbjct: 703 VCLLGDKLYAVGGYDG----QAYLNTVEAYDPQTNEWTQVA 739
Score = 47.8 bits (112), Expect = 3e-05
Identities = 46/185 (24%), Positives = 80/185 (43%), Gaps = 31/185 (16%)
Query: 301 YDPVSRKTYFI---SSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYR 357
+DP +R+ F+ S+P+ G+ V+ V G +S L K+VE +
Sbjct: 581 WDPQARQWNFVATMSTPRSTVGVA------VLSGKLYAVGGRDGSSCL-----KSVECFD 629
Query: 358 YHDRGNQFWEKLCTAEFRELYALG--SIHNDLYVIGGQMKIKNQYL--ITNCVDKYSVER 413
H W LC + +G + + LY IGG + +++CV++Y +
Sbjct: 630 PHTNK---WT-LCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKT 685
Query: 414 DNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWS 473
D W V+ + + V + +KLY +GG+ Q L N + YDP ++W+
Sbjct: 686 DMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYL---------NTVEAYDPQTNEWT 736
Query: 474 VRAPM 478
AP+
Sbjct: 737 QVAPL 741
Score = 37.4 bits (85), Expect = 0.042
Identities = 36/138 (26%), Positives = 57/138 (41%), Gaps = 14/138 (10%)
Query: 300 CYDPVSRKTYFISSPKYGEGLGTVCTGVVMENNTIIVAG--EASASKLSRQKNKNVEIYR 357
C+DP + K + G GV N + G +A AS L+ + + VE Y
Sbjct: 627 CFDPHTNKWTLCAQMSKRRG----GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERY- 681
Query: 358 YHDRGNQFWEKLCTAEF-RELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNW 416
D W + + R+ + + + LY +GG + N V+ Y + + W
Sbjct: 682 --DPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGY----DGQAYLNTVEAYDPQTNEW 735
Query: 417 KRVSPLPLQLACHAVVTV 434
+V+PL L A VVTV
Sbjct: 736 TQVAPLCLGRAGACVVTV 753
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 198 bits (503), Expect = 1e-50
Identities = 152/586 (25%), Positives = 250/586 (42%), Gaps = 64/586 (10%)
Query: 13 HSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREV 72
HS LL + +++ E+ D++L K H++VLA+ SPYFKAMFT L E EV
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
Query: 73 ILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASN 132
I ++ ++ Y Y + I+ V+++ AA +Q++ V C ++ +D N
Sbjct: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
Query: 133 CLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREE 192
C+GI FA+ G DL + KY+ Q+F V EE E+ ++ +D LN++ EE
Sbjct: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
Query: 193 SILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQN 252
++ + W+ ++ + R +L +LL VRL L++ FL + N ++ D C ++
Sbjct: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
Query: 253 AFKAIKTPQ---QHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSRKTY 309
A K P+ H L +LC SG+ + C D V + Y
Sbjct: 257 ALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFA----------CLDSV--EMY 304
Query: 310 F-----------ISSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRY 358
F ++ P+Y G+ V++ ++ G A+ + K+
Sbjct: 305 FPQNDSWIGLAPLNIPRYEFGI------CVLDQKVYVIGGIATNVRPGVTIRKHENSVEC 358
Query: 359 HDRGNQFWEKL-CTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWK 417
+ W L E R + + +LY +GG YL V+KY + W+
Sbjct: 359 WNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGY--DGQSYL--QSVEKYIPKIRKWQ 414
Query: 418 RVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAP 477
V+P+ +C A ++ +Y IGG+ P N + +YDPS+D W + A
Sbjct: 415 PVAPMTTTRSCFAAAVLDGMIYAIGGYGPAH----------MNSVERYDPSKDSWEMVAS 464
Query: 478 MKYSKYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPL 537
M + F V+ I+V+GG V L +E Y+P + W PM P
Sbjct: 465 MADKRIHFGVGVMLGFIFVVGGHNGVSH--------LSSIERYDPHQNQWTVCRPMKEP- 515
Query: 538 LSLRTNSTNAGAVDGKLYVCGGFHGADRHEVISKEILELDPWENQW 583
A +D LYV GG G+ + K DP + W
Sbjct: 516 ----RTGVGAAVIDNYLYVVGGHSGSSYLNTVQK----YDPISDTW 553
Score = 43.5 bits (101), Expect = 6e-04
Identities = 29/128 (22%), Positives = 55/128 (42%), Gaps = 14/128 (10%)
Query: 359 HDRGNQFWEKLCT-AEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWK 417
+D WE + + A+ R + +G + ++V+GG + + + +++Y ++ W
Sbjct: 452 YDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSH----LSSIERYDPHQNQWT 507
Query: 418 RVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAP 477
P+ ++N LYV+GG + L N + +YDP D W A
Sbjct: 508 VCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYL---------NTVQKYDPISDTWLDSAG 558
Query: 478 MKYSKYRF 485
M Y + F
Sbjct: 559 MIYCRCNF 566
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 197 bits (502), Expect = 2e-50
Identities = 145/570 (25%), Positives = 252/570 (44%), Gaps = 57/570 (10%)
Query: 21 IQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAE 80
++ ++ ++ DV L KF HR+VLAA PYF AMFT ++EC Q E+++ +
Sbjct: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
Query: 81 SVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGIYYFA 140
++ L+N+ YN L I+ NVQ++ M A F+Q++ + C ++ + + NCLG+ FA
Sbjct: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
Query: 141 KQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLR 200
+ + L D + +++QHF EVS+ EE L + + L L+ D+LN+ EE + + L
Sbjct: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALA 207
Query: 201 WVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQNAFKAIKTP 260
WV +++E R +L ELL +RL L P FL ++++ ++ C C D++ A P
Sbjct: 208 WVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMP 267
Query: 261 QQH------SLNLRYGMETTSLLLCIGNNSSGIRSRH--RSYGDASFCYDPVSRKTYFIS 312
++ R L+ +G +S S + + + C++ T S
Sbjct: 268 ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARS 327
Query: 313 SPKYGEGLGTVCTGVVMENNTI-IVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEKLCT 371
GV + N + + G +LS + N E W ++ +
Sbjct: 328 R-----------VGVAVVNGLLYAIGGYDGQLRLSTVEAYNPE--------TDTWTRVGS 368
Query: 372 AEFRELYALGSIHND--LYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACH 429
+ A+G++ D +YV GG + + V+ YS E D W V+ + +
Sbjct: 369 MNSKR-SAMGTVVLDGQIYVCGGY----DGNSSLSSVETYSPETDKWTVVTSMSSNRSAA 423
Query: 430 AVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAV 489
V ++YV GG + ++ + + Y+ W A M + R A
Sbjct: 424 GVTVFEGRIYVSGG---------HDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAAS 474
Query: 490 VNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGA 549
+ S+++V GG G L + E+Y+ D W PM + R + + A
Sbjct: 475 LGSKMFVCGGYDGSG--------FLSIAEMYSSVADQWCLIVPMHT-----RRSRVSLVA 521
Query: 550 VDGKLYVCGGFHGADRHEVISKEILELDPW 579
G+LY GG+ G + E D W
Sbjct: 522 SCGRLYAVGGYDGQSNLSSVEMYDPETDCW 551
Score = 45.4 bits (106), Expect = 2e-04
Identities = 37/147 (25%), Positives = 59/147 (40%), Gaps = 21/147 (14%)
Query: 387 LYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTP 446
+YV GG ++ I + V+ Y+ W + + + H ++ +K++V GG+
Sbjct: 432 IYVSGGHDGLQ----IFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDG 487
Query: 447 QMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGIGCVGQD 506
L E Y DQW + PM + R S +Y +GG GQ
Sbjct: 488 SGFLSIAE---------MYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYD--GQS 536
Query: 507 KGQVRKCLDVVEIYNPDGDFWREGPPM 533
L VE+Y+P+ D W PM
Sbjct: 537 N------LSSVEMYDPETDCWTFMAPM 557
Score = 38.5 bits (88), Expect = 0.019
Identities = 25/101 (24%), Positives = 44/101 (43%), Gaps = 13/101 (12%)
Query: 378 YALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNK 437
+ S+ + ++V GG + + + YS D W + P+ + + ++V +
Sbjct: 470 HGAASLGSKMFVCGGY----DGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGR 525
Query: 438 LYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPM 478
LY +GG+ Q +L E YDP D W+ APM
Sbjct: 526 LYAVGGYDGQSNLSSVE---------MYDPETDCWTFMAPM 557
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 195 bits (495), Expect = 1e-49
Identities = 146/585 (24%), Positives = 257/585 (43%), Gaps = 51/585 (8%)
Query: 2 ECKIEGKEKYQHSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFT 61
E K+ +E+ + + + NM++ + DV+L + K P HR+VLAA S +F MFT
Sbjct: 15 EKKLAAREEAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFT 74
Query: 62 CGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQ 121
+LE EV L D + + L+ + Y A + +N+ NVQ++ AA Q+E V +C
Sbjct: 75 TNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCV 134
Query: 122 KYMMDHMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLI 181
++ + +DASNCLGI A+ + +L + +++QHF EV +E L+++V + L+
Sbjct: 135 DFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLL 194
Query: 182 KSDDLNISREESILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLL 241
D L + E+ + D +RW+ +++ R +V++L +VR L++ +FL + ++ ++
Sbjct: 195 NQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQ 254
Query: 242 CDADCVDIIQNAFKAIKTPQQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCY 301
+ +C+ ++ I + H L+ E + + R + Y A F
Sbjct: 255 DNPECLKMV------ISGMRYHLLSPEDREELV--------DGTRPRRKKHDYRIALFGG 300
Query: 302 DPVSRKTYFISSPKYGEGLGTVC-------TGVVMENNTIIVAGEASASKLSRQKNKNVE 354
YF +PK C V +N + + G + + R NV
Sbjct: 301 SQPQSCRYF--NPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFPIKRMDCYNVV 358
Query: 355 IYRYHDRGNQFWEKLCTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERD 414
+ ++ KL R+ A + +Y GG + + C Y +
Sbjct: 359 -------KDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFEC---YDTRTE 408
Query: 415 NWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSV 474
+W + Q H +V N +YV GG L + R+ N YDP+ + W+
Sbjct: 409 SWHTKPSMLTQRCSHGMVEANGLIYVCGG-----SLGNNVSGRVLNSCEVYDPATETWTE 463
Query: 475 RAPMKYSKYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMP 534
PM ++ V +I+ +GG +G LD VE Y+ + W+ PMP
Sbjct: 464 LCPMIEARKNHGLVFVKDKIFAVGGQNGLGG--------LDNVEYYDIKLNEWKMVSPMP 515
Query: 535 SPLLSLRTNSTNAGAVDGKLYVCGGFHGADRHEVISKEILELDPW 579
++++ AV +YV GF G R I + E D W
Sbjct: 516 WKGVTVK-----CAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555
>gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Homo
sapiens]
Length = 623
Score = 193 bits (491), Expect = 3e-49
Identities = 159/634 (25%), Positives = 283/634 (44%), Gaps = 60/634 (9%)
Query: 1 MECKIEGKEKYQHSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMF 60
M + E + +++++LL +++ E D+VL EG +FPCH++VLA S YF+AMF
Sbjct: 1 MSTQDERQINTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMF 60
Query: 61 TCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVC 120
GL E Q V L ++ A ++ +++ Y Y L +N++ V+ + A F+Q+E+V C
Sbjct: 61 MSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRC 120
Query: 121 QKYMMDHMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTL 180
++Y++ ++A NC+ + FA E+L +K+ + F V + +++ + +
Sbjct: 121 REYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDI 180
Query: 181 IKSDDLNISREESILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLR---QALRRN 237
+ SD+LN+ +EE++ + + W+ +N E R+ +L +L Q+R++ ++ R Q L N
Sbjct: 181 LSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPN 240
Query: 238 TMLLCDADCVDIIQNAFKAIKTPQQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDA 297
D ++Q +K++ R GM +++ I +S S + +
Sbjct: 241 -------DKSVVVQGLYKSM----PKFFKPRLGMTKEEMMIFIEASSENPCSLY-----S 284
Query: 298 SFCYDPVSRKTYFISSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEI-- 355
S CY P + K Y + SP L V T V +N+ I G+ +K ++
Sbjct: 285 SVCYSPQAEKVYKLCSPP--ADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQT 342
Query: 356 --------YRYHDRGNQFWEKLCTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVD 407
Y + + N ++ K R +L +Y IGG L V+
Sbjct: 343 AFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDS--VGGELNRRTVE 400
Query: 408 KYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDP 467
+Y E+D W VSPLP A V V++ +YV+ N + Y P
Sbjct: 401 RYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVM----------------TLNLMYCYFP 444
Query: 468 SQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGI-----GCVGQDKGQVRKCLDVVEIYNP 522
D W A + S+ S A +I+ +GG+ + G V VEIY+
Sbjct: 445 RSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTVEIYDV 504
Query: 523 DGDFWREGPPMPSPLLSLRTNSTNAGAVDGKLYV-CGGFHGADRHEVISKEI-LELDPWE 580
+ + W+ +P+ S A + L V H +R + ++ + LELD W
Sbjct: 505 NKNEWKMAANIPAKRYS--DPCVRAVVISNSLCVFMRETHLNERAKYVTYQYDLELDRWS 562
Query: 581 NQWNVVAINVLMHDSYDV-CLVARMNPRDLIPPP 613
+ + ++ VL D C V ++ P L P
Sbjct: 563 LRQH-ISERVLWDLGRDFRCTVGKLYPSCLEESP 595
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 187 bits (475), Expect = 2e-47
Identities = 141/557 (25%), Positives = 244/557 (43%), Gaps = 51/557 (9%)
Query: 30 MIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYM 89
+ DV+L + K P HR+VLAA S +F MFT +LE EV L D + + L+ +
Sbjct: 21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFA 80
Query: 90 YNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGIYYFAKQIGAEDLS 149
Y A + +N+ NVQ++ AA Q+E V +C ++ + +DASNCLGI A+ + +L
Sbjct: 81 YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELK 140
Query: 150 DRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELR 209
+ +++QHF EV +E L+++V + L+ D L + E+ + D +RW+ +++ R
Sbjct: 141 ATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNR 200
Query: 210 TVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQNAFKAIKTPQQHSLNLRY 269
+V++L +VR L++ +FL + ++ ++ + +C+ ++ I + H L+
Sbjct: 201 QPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMV------ISGMRYHLLSPED 254
Query: 270 GMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSRKTYFISSPKYGEGLGTVC----- 324
E + + R + Y A F YF +PK C
Sbjct: 255 REELV--------DGTRPRRKKHDYRIALFGGSQPQSCRYF--NPKDYSWTDIRCPFEKR 304
Query: 325 --TGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEKLCTAEFRELYALGS 382
V +N + + G + + R NV + ++ KL R+ A +
Sbjct: 305 RDAACVFWDNVVYILGGSQLFPIKRMDCYNVV-------KDSWYSKLGPPTPRDSLAACA 357
Query: 383 IHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIG 442
+Y GG + + C Y ++W + Q H +V N +YV G
Sbjct: 358 AEGKIYTSGGSEVGNSALYLFEC---YDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCG 414
Query: 443 GWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGIGC 502
G L + R+ N YDP+ + W+ PM ++ V +I+ +GG
Sbjct: 415 G-----SLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNG 469
Query: 503 VGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGAVDGKLYVCGGFHG 562
+G LD VE Y+ + W+ PMP ++++ AV +YV GF G
Sbjct: 470 LGG--------LDNVEYYDIKLNEWKMVSPMPWKGVTVK-----CAAVGSIVYVLAGFQG 516
Query: 563 ADRHEVISKEILELDPW 579
R I + E D W
Sbjct: 517 VGRLGHILEYNTETDKW 533
>gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Homo
sapiens]
Length = 606
Score = 185 bits (470), Expect = 9e-47
Identities = 134/628 (21%), Positives = 283/628 (45%), Gaps = 75/628 (11%)
Query: 11 YQHSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQR 70
YQ +L L + ++++ + + ID L A + PCHRL+L+A SPYF+ F + E ++
Sbjct: 14 YQSTL-LQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKK 72
Query: 71 EVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDA 130
EV+L ++ + +++ Y+Y+A++++N+ NVQ + A Q+ VF+VC Y+ +
Sbjct: 73 EVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAP 132
Query: 131 SNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISR 190
NCL I + L+ +++++ F ++ E+ +++ + +++I +D LN+ +
Sbjct: 133 GNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEK 192
Query: 191 EESILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADC---V 247
EE++ + V++WV +KE R +L E+ +R L+ + + + ++ ++ + D +
Sbjct: 193 EEAVFEAVMKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKI 252
Query: 248 DIIQNAFKA-IKTPQQHSLNL-----------------------RYGMETTSLLLCIGNN 283
++++AF + P +++ R+GM L+L + +
Sbjct: 253 KVLKDAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDT 312
Query: 284 SSGIRSRHRSYGDASFCYDPVSRKTYFISSPKYGEGLGTVCTGVVMENNTIIVAGEASAS 343
A+ YDP + Y + E + + +V + N I V G
Sbjct: 313 -------------AAVAYDPTENECYLTA---LAEQIPRNHSSIVTQQNQIYVVGGLYVD 356
Query: 344 KLSRQKNKNVEIYRYHDRGNQFWEKLCTAEFRELYALGSIHNDLYVIGGQ-MKIKNQYLI 402
+ ++ + ++ +++ R L+ LG + + +YV+ G+ ++ +
Sbjct: 357 EENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDS 416
Query: 403 TNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKL 462
C D + + W V LP+++ H V++ +Y +GG T + + +N++
Sbjct: 417 VLCYDPVAAK---WNEVKKLPIKVYGHNVISHKGMIYCLGGKT--------DDKKCTNRV 465
Query: 463 LQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNP 522
++P + W APMK + F AV +I + GG+ G VE ++
Sbjct: 466 FIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSAS--------VEAFDL 517
Query: 523 DGDFWREGPPMPSPLLSLRTNSTNAGAVDGKLYVCGGFH--GADRHEVISKEILELDPWE 580
+ W P +S + ++ G LY GGF + E E+ ++ +E
Sbjct: 518 TTNKWDVMTEFPQ-----ERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYE 572
Query: 581 N---QWNVVAINVLMHDSYDVCLVARMN 605
+ +W + + + S CL R+N
Sbjct: 573 DDKKEW-AGMLKEIRYASGASCLATRLN 599
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 183 bits (465), Expect = 4e-46
Identities = 153/577 (26%), Positives = 256/577 (44%), Gaps = 55/577 (9%)
Query: 2 ECKIE------GKEKYQHSLNLLNK----IQNMKELAEMI-DVVLT-----AEGEKFPCH 45
ECK E G + ++L K I N L++ + DV L A +F H
Sbjct: 37 ECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAH 96
Query: 46 RLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVA 105
++VLA+ SP FKAMFT GL E V + I + + L+ + Y A++ + V V
Sbjct: 97 KVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVM 156
Query: 106 MAAYFMQMEEVFSVCQKYMMDHMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSL 165
A Q++ V C +++ +D SN +GI FA+QIG +L R+++Y+Y HF EV+
Sbjct: 157 NGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAK 216
Query: 166 HEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRTVHLVELLKQVRLELV 225
EE + Q +TLI DDLN+ E + + WV ++ E R ++ LL+ VR +
Sbjct: 217 QEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSL 276
Query: 226 NPSFLRQALRRNTMLLCDADCVDIIQNAFKAIKTPQQHSLNLRYGMETTSLLLCIGNNSS 285
P+FL+ L++ +L D+ C D + F+ + + + + L+ G
Sbjct: 277 TPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAG---- 332
Query: 286 GIRSRHRSYGDASFCYDPVSRKTYFISSPKYGEGLGTVCTGVVMENNTIIVAGEASASKL 345
G + SY +A D + + P+ G G V+ V G ++
Sbjct: 333 GYFRQSLSYLEAYNPSDGTWLRLADLQVPRSG------LAGCVVGGLLYAVGGRNNSPDG 386
Query: 346 SRQKNKNVEIYRYHDRGNQFWEKLCTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNC 405
+ + + Y+ NQ+ + R +G I +Y +GG + + N
Sbjct: 387 NTDSS---ALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGG----SHGCIHHNS 439
Query: 406 VDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQY 465
V++Y ERD W V+P+ + V +N LY +GG+ + +RL N Y
Sbjct: 440 VERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGF--------DGTNRL-NSAECY 490
Query: 466 DPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGD 525
P +++W + M + V+++ IY GG GQD+ L+ VE Y+ + +
Sbjct: 491 YPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYD--GQDQ------LNSVERYDVETE 542
Query: 526 FWREGPPMPSPLLSLRTNSTNAGAVDGKLYVCGGFHG 562
W PM R ++ G++YV GG+ G
Sbjct: 543 TWTFVAPMKH-----RRSALGITVHQGRIYVLGGYDG 574
Score = 71.6 bits (174), Expect = 2e-12
Identities = 59/216 (27%), Positives = 94/216 (43%), Gaps = 29/216 (13%)
Query: 387 LYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTP 446
+Y GG + YL + Y+ W R++ L + + A V LY +GG
Sbjct: 328 IYTAGGYFRQSLSYL-----EAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGG--- 379
Query: 447 QMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGI-GCVGQ 505
+ + PD D S+ L Y+P +QWS APM + R V++ IY +GG GC+
Sbjct: 380 RNNSPDGNTD--SSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHH 437
Query: 506 DKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGAVDGKLYVCGGFHGADR 565
+ VE Y P+ D W + +P+L+ R ++ LY GGF G +R
Sbjct: 438 NS---------VERYEPERDEWH----LVAPMLTRRI-GVGVAVLNRLLYAVGGFDGTNR 483
Query: 566 HEVISKEILELDPWENQWNVVAINVLMHDSYDVCLV 601
+ S E P N+W ++ + VC++
Sbjct: 484 --LNSAECYY--PERNEWRMITAMNTIRSGAGVCVL 515
Score = 61.2 bits (147), Expect = 3e-09
Identities = 42/195 (21%), Positives = 84/195 (43%), Gaps = 26/195 (13%)
Query: 387 LYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTP 446
LY +GG+ + ++ +D Y+ + W +P+ + V ++ +Y +GG
Sbjct: 374 LYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHG 433
Query: 447 QMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGIGCVGQD 506
+ N + +Y+P +D+W + APM + AV+N +Y +GG +
Sbjct: 434 CIH---------HNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR- 483
Query: 507 KGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGA--VDGKLYVCGGFHGAD 564
L+ E Y P+ + WR + ++ T + AG + +Y GG+ G D
Sbjct: 484 -------LNSAECYYPERNEWRM-------ITAMNTIRSGAGVCVLHNCIYAAGGYDGQD 529
Query: 565 RHEVISKEILELDPW 579
+ + + +E + W
Sbjct: 530 QLNSVERYDVETETW 544
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 183 bits (465), Expect = 4e-46
Identities = 153/577 (26%), Positives = 256/577 (44%), Gaps = 55/577 (9%)
Query: 2 ECKIE------GKEKYQHSLNLLNK----IQNMKELAEMI-DVVLT-----AEGEKFPCH 45
ECK E G + ++L K I N L++ + DV L A +F H
Sbjct: 37 ECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAH 96
Query: 46 RLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVA 105
++VLA+ SP FKAMFT GL E V + I + + L+ + Y A++ + V V
Sbjct: 97 KVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVM 156
Query: 106 MAAYFMQMEEVFSVCQKYMMDHMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSL 165
A Q++ V C +++ +D SN +GI FA+QIG +L R+++Y+Y HF EV+
Sbjct: 157 NGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAK 216
Query: 166 HEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRTVHLVELLKQVRLELV 225
EE + Q +TLI DDLN+ E + + WV ++ E R ++ LL+ VR +
Sbjct: 217 QEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSL 276
Query: 226 NPSFLRQALRRNTMLLCDADCVDIIQNAFKAIKTPQQHSLNLRYGMETTSLLLCIGNNSS 285
P+FL+ L++ +L D+ C D + F+ + + + + L+ G
Sbjct: 277 TPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAG---- 332
Query: 286 GIRSRHRSYGDASFCYDPVSRKTYFISSPKYGEGLGTVCTGVVMENNTIIVAGEASASKL 345
G + SY +A D + + P+ G G V+ V G ++
Sbjct: 333 GYFRQSLSYLEAYNPSDGTWLRLADLQVPRSG------LAGCVVGGLLYAVGGRNNSPDG 386
Query: 346 SRQKNKNVEIYRYHDRGNQFWEKLCTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNC 405
+ + + Y+ NQ+ + R +G I +Y +GG + + N
Sbjct: 387 NTDSS---ALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGG----SHGCIHHNS 439
Query: 406 VDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQY 465
V++Y ERD W V+P+ + V +N LY +GG+ + +RL N Y
Sbjct: 440 VERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGF--------DGTNRL-NSAECY 490
Query: 466 DPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGD 525
P +++W + M + V+++ IY GG GQD+ L+ VE Y+ + +
Sbjct: 491 YPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYD--GQDQ------LNSVERYDVETE 542
Query: 526 FWREGPPMPSPLLSLRTNSTNAGAVDGKLYVCGGFHG 562
W PM R ++ G++YV GG+ G
Sbjct: 543 TWTFVAPMKH-----RRSALGITVHQGRIYVLGGYDG 574
Score = 71.6 bits (174), Expect = 2e-12
Identities = 59/216 (27%), Positives = 94/216 (43%), Gaps = 29/216 (13%)
Query: 387 LYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTP 446
+Y GG + YL + Y+ W R++ L + + A V LY +GG
Sbjct: 328 IYTAGGYFRQSLSYL-----EAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGG--- 379
Query: 447 QMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGI-GCVGQ 505
+ + PD D S+ L Y+P +QWS APM + R V++ IY +GG GC+
Sbjct: 380 RNNSPDGNTD--SSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHH 437
Query: 506 DKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGAVDGKLYVCGGFHGADR 565
+ VE Y P+ D W + +P+L+ R ++ LY GGF G +R
Sbjct: 438 NS---------VERYEPERDEWH----LVAPMLTRRI-GVGVAVLNRLLYAVGGFDGTNR 483
Query: 566 HEVISKEILELDPWENQWNVVAINVLMHDSYDVCLV 601
+ S E P N+W ++ + VC++
Sbjct: 484 --LNSAECYY--PERNEWRMITAMNTIRSGAGVCVL 515
Score = 61.2 bits (147), Expect = 3e-09
Identities = 42/195 (21%), Positives = 84/195 (43%), Gaps = 26/195 (13%)
Query: 387 LYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTP 446
LY +GG+ + ++ +D Y+ + W +P+ + V ++ +Y +GG
Sbjct: 374 LYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHG 433
Query: 447 QMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGIGCVGQD 506
+ N + +Y+P +D+W + APM + AV+N +Y +GG +
Sbjct: 434 CIH---------HNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR- 483
Query: 507 KGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGA--VDGKLYVCGGFHGAD 564
L+ E Y P+ + WR + ++ T + AG + +Y GG+ G D
Sbjct: 484 -------LNSAECYYPERNEWRM-------ITAMNTIRSGAGVCVLHNCIYAAGGYDGQD 529
Query: 565 RHEVISKEILELDPW 579
+ + + +E + W
Sbjct: 530 QLNSVERYDVETETW 544
>gi|21359972 kelch repeat and BTB (POZ) domain containing 7 [Homo
sapiens]
Length = 684
Score = 181 bits (460), Expect = 1e-45
Identities = 167/650 (25%), Positives = 282/650 (43%), Gaps = 104/650 (16%)
Query: 13 HSLNLLNKIQNMKELAEMIDVVLTA--------EGEKFPCHRLVLAAFSPYFKAMFTCGL 64
HS LL ++++ + + DV + G F C+R VLAA PYFK+MFT G+
Sbjct: 45 HSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGM 104
Query: 65 LECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
E Q V ++D+ AES VL++Y Y + ++ ANVQ + A+ +Q+E V C ++
Sbjct: 105 YESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
Query: 125 MDHMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEV----SLHEEIL-EIEVHQFLT 179
+D +NC I FA L +++ Y+ +F ++ S+ EE L ++ + Q L
Sbjct: 165 ARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLA 224
Query: 180 LIKSDDLNISREESILDLVLRWVNHNKELRTVHLVELLKQVR---LELVNPSFLRQALRR 236
+++ D L+I E ++ + ++W+ + R E+ K VR + +L L
Sbjct: 225 VLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLL-- 282
Query: 237 NTMLLCDADCVDIIQNAFKAIKTPQQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYG- 295
T + C+D+I+ A L +RYG L+ + N+SS S +
Sbjct: 283 -TKPIVKKYCLDVIEGA-----------LQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSA 330
Query: 296 -----------------------DASFCYDPVSRKTYFISSPKYGEGLGTVCTGVVMENN 332
D CYDP S Y + SP L + + ++
Sbjct: 331 AENPPQRLGMCAKEMVIFFGHPRDPFLCYDPYSGDIYTMPSP-----LTSFAHTKTVTSS 385
Query: 333 TIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEKLCTAEF-RELYALGSIHNDLYVIG 391
+ V+ + L+ Q K++ +Y+ W++L RE + ++ +Y++G
Sbjct: 386 AVCVSPDHDI-YLAAQPRKDLWVYK---PAQNSWQQLADRLLCREGMDVAYLNGYIYILG 441
Query: 392 GQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLP 451
G+ I L V+ YSV+R+ W V+P+P ++ V N LY +
Sbjct: 442 GRDPITGVKL--KEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVN--------- 490
Query: 452 DEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGIGCVGQDKGQVR 511
S ++L YDPS + W A +K S ++ V N EIY + I
Sbjct: 491 -------SKRMLCYDPSHNMWLNCASLKRSDFQ-EACVFNDEIYCICDI----------- 531
Query: 512 KCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGAVDGKLYVCGGFHGADRHEVISK 571
V+++YNP WR +P L T++ D KL + + ++
Sbjct: 532 ---PVMKVYNPARGEWRRISNIP---LDSETHNYQIVNHDQKLLLITSTTPQWKKNRVT- 584
Query: 572 EILELDPWENQW-NV-VAINVLMHDSYDVCLVARMNPRDLIPPPSDLVEE 619
+ E D E+QW N+ + +L DS +CL AR+ P L P S + EE
Sbjct: 585 -VYEYDTREDQWINIGTMLGLLQFDSGFICLCARVYPSCLEPGQSFITEE 633
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 179 bits (454), Expect = 7e-45
Identities = 153/624 (24%), Positives = 264/624 (42%), Gaps = 91/624 (14%)
Query: 12 QHSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQRE 71
+H+ +L +I M+ DV L E F HRLVLAA SPYF A+FT G+ E ++
Sbjct: 18 KHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDV 77
Query: 72 VILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDAS 131
V + I A +LL+++Y + I NVQ + +AA +Q+ EV +C +++ +D
Sbjct: 78 VPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPL 137
Query: 132 NCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISRE 191
NC+GI+ F++QI DL + S+ Y++ HF EV EE L + Q + +++S++L+I E
Sbjct: 138 NCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDE 197
Query: 192 ESILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQ 251
+ ++W+ + R H+VE+L +R L+ P L + + + +++
Sbjct: 198 YQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLK 257
Query: 252 NAFKAIKTPQQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSRKTYFI 311
+ K+P+++ C +S +R R +
Sbjct: 258 EYCEVCKSPKENK-------------FCSFLQTSKVRPRKK------------------- 285
Query: 312 SSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEKLCT 371
+ KY +G T + G S S+ + D +Q+W + +
Sbjct: 286 -ARKYLYAVG---------GYTRLQGGRWSDSRA-------LSCVERFDTFSQYWTTVSS 328
Query: 372 A-EFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHA 430
+ R + + +Y IGG+ +I +C + Y W V+ +
Sbjct: 329 LHQARSGLGVTVLGGMVYAIGGE----KDSMIFDCTECYDPVTKQWTTVASMNHPRCGLG 384
Query: 431 VVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVV 490
V +Y +GGW + N + ++DP +++W V M S+Y F +
Sbjct: 385 VCVCYGAIYALGGWVGA---------EIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEM 435
Query: 491 NSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGAV 550
IYV+GGI G + L E+Y+P W PPM R A+
Sbjct: 436 QGLIYVIGGISNEGIE-------LRSFEVYDPLSKRWSPLPPM-----GTRRAYLGVAAL 483
Query: 551 DGKLYVCGGFHGA-DRHEVISKEILELDPWENQWN---------VVAINVLMHDSYDVCL 600
+ +Y GG++ D + K E + W + VVA+N L++ S
Sbjct: 484 NDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVS----- 538
Query: 601 VARMNPRDLIPPPS-DLVEEGNEH 623
R + D + P + D VE N H
Sbjct: 539 GGRSSSHDFLAPGTLDSVEVYNPH 562
Score = 65.5 bits (158), Expect = 1e-10
Identities = 61/237 (25%), Positives = 97/237 (40%), Gaps = 29/237 (12%)
Query: 296 DASFCYDPVSRKTYFISSPKYGE-GLGT-VCTGVVMENNTIIVAGEASASKLSRQKNKNV 353
D + CYDPV+++ ++S + GLG VC G + A + + +
Sbjct: 358 DCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIY----------ALGGWVGAEIGNTI 407
Query: 354 EIYRYHDRGNQFWEKLCT-AEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVE 412
E + D WE + A R + + +YVIGG I N+ + + Y
Sbjct: 408 ERF---DPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGG---ISNEGIELRSFEVYDPL 461
Query: 413 RDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQW 472
W + P+ + A V +N+ +Y +GGW +E D L + + +Y +++W
Sbjct: 462 SKRWSPLPPMGTRRAYLGVAALNDCIYSVGGW-------NETQDAL-HTVEKYSFEEEKW 513
Query: 473 SVRAPMKYSKYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWRE 529
A MK + VN +YV GG LD VE+YNP D W E
Sbjct: 514 VEVASMKVPRAGMCVVAVNGLLYVSGGRS--SSHDFLAPGTLDSVEVYNPHSDTWTE 568
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 179 bits (454), Expect = 7e-45
Identities = 142/556 (25%), Positives = 237/556 (42%), Gaps = 50/556 (8%)
Query: 38 EGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVLLNYMYNAALEIN 97
E + C RLVL++ S YF AMFT + E Q E+ + + S+ L+ Y Y LE+
Sbjct: 167 ESDSSSC-RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELK 225
Query: 98 NANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGIYYFAKQIGAEDLSDRSKKYLY 157
N++ + A +Q+ +V C K++M + SNCLGI FA G DL + Y
Sbjct: 226 EDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTM 285
Query: 158 QHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHNKELRTVHLVELL 217
+HF EV ++E + + + L+ SDD+NI EE+IL+ +L WV H+ E R L +LL
Sbjct: 286 EHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLL 345
Query: 218 KQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQNAFK----AIKTPQQHSLNLRYGMET 273
+RL L+ P FL + N + D +C +I A K + P S + T
Sbjct: 346 AYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKST 404
Query: 274 TSLLLCIG--NNSSGIRSRHRSYGDASFCYDPVSRKTYFISSPKYGEGLGTVCTGVVMEN 331
L +G +++ G S + Y + + PV+ ++ + G+ V+++
Sbjct: 405 VGTLFAVGGMDSTKGATSIEK-YDLRTNMWTPVAN----MNGRRLQFGV------AVLDD 453
Query: 332 NTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEKLCTAEFRELYALGSIHNDLYVIG 391
+V G L+ VE Y + + T R + + +Y +G
Sbjct: 454 KLYVVGGRDGLKTLN-----TVECYNPKTKTWSVMPPMST--HRHGLGVAVLEGPMYAVG 506
Query: 392 GQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLP 451
G + + N V+++ + W V+ + + V ++ KLY +GG L
Sbjct: 507 GH----DGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLK 562
Query: 452 DEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGIGCVGQDKGQVR 511
E +DP ++W++ A M + N +Y +GG +
Sbjct: 563 SVE---------CFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASN--LTS 611
Query: 512 KCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGAVDGKLYVCGGFHGADRHEVISK 571
+ D VE Y+P D W M S+ ++ + KLY GG+ G +
Sbjct: 612 RLSDCVERYDPKTDMWTAVASM-----SISRDAVGVCLLGDKLYAVGGYDG----QAYLN 662
Query: 572 EILELDPWENQWNVVA 587
+ DP N+W VA
Sbjct: 663 TVEAYDPQTNEWTQVA 678
Score = 47.8 bits (112), Expect = 3e-05
Identities = 46/185 (24%), Positives = 80/185 (43%), Gaps = 31/185 (16%)
Query: 301 YDPVSRKTYFI---SSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYR 357
+DP +R+ F+ S+P+ G+ V+ V G +S L K+VE +
Sbjct: 520 WDPQARQWNFVATMSTPRSTVGVA------VLSGKLYAVGGRDGSSCL-----KSVECFD 568
Query: 358 YHDRGNQFWEKLCTAEFRELYALG--SIHNDLYVIGGQMKIKNQYL--ITNCVDKYSVER 413
H W LC + +G + + LY IGG + +++CV++Y +
Sbjct: 569 PHTNK---WT-LCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKT 624
Query: 414 DNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWS 473
D W V+ + + V + +KLY +GG+ Q L N + YDP ++W+
Sbjct: 625 DMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYL---------NTVEAYDPQTNEWT 675
Query: 474 VRAPM 478
AP+
Sbjct: 676 QVAPL 680
Score = 37.4 bits (85), Expect = 0.042
Identities = 36/138 (26%), Positives = 57/138 (41%), Gaps = 14/138 (10%)
Query: 300 CYDPVSRKTYFISSPKYGEGLGTVCTGVVMENNTIIVAG--EASASKLSRQKNKNVEIYR 357
C+DP + K + G GV N + G +A AS L+ + + VE Y
Sbjct: 566 CFDPHTNKWTLCAQMSKRRG----GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERY- 620
Query: 358 YHDRGNQFWEKLCTAEF-RELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNW 416
D W + + R+ + + + LY +GG + N V+ Y + + W
Sbjct: 621 --DPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGY----DGQAYLNTVEAYDPQTNEW 674
Query: 417 KRVSPLPLQLACHAVVTV 434
+V+PL L A VVTV
Sbjct: 675 TQVAPLCLGRAGACVVTV 692
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 178 bits (452), Expect = 1e-44
Identities = 143/590 (24%), Positives = 255/590 (43%), Gaps = 54/590 (9%)
Query: 8 KEKYQ---HSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGL 64
+E YQ H+ K+++ + ++ DV+L K P HRLVL++ S YF AMFT +
Sbjct: 186 EEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDV 245
Query: 65 LECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
E Q E+ + I ++ L+ + Y LE+ ++ + AA +Q+ +V VC ++
Sbjct: 246 CEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFL 305
Query: 125 MDHMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSD 184
M + SNCLGI FA G +L + Y ++ EV ++E L + + L+ SD
Sbjct: 306 MKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASD 365
Query: 185 DLNISREESILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDA 244
D+N+ EE+I ++ WV ++ + R L LL +RL L+ P L L + + D
Sbjct: 366 DVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDL 424
Query: 245 DCVDIIQNAFKAIKTPQQHSL----NLRYGMETTSLLLCIG--NNSSGIRSRHRSYGDAS 298
+C +I A K P++ +L + T L +G +N+ G + +
Sbjct: 425 ECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEK------ 478
Query: 299 FCYDPVSRKTYFISSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRY 358
YD + + + G L GV + ++ + V G R K +
Sbjct: 479 --YD-LRTNLWIQAGMMNGRRLQ---FGVAVIDDKLFVIG-------GRDGLKTLNTVEC 525
Query: 359 HDRGNQFWEKL-CTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWK 417
++ + W L + R + + +Y +GG + + N V+++ + W
Sbjct: 526 YNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGH----DGWSYLNTVERWDPQSQQWT 581
Query: 418 RVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAP 477
V+ + + + V +N KLY +GG + + + YDP ++W++ AP
Sbjct: 582 FVASMSIARSTVGVAALNGKLYSVGG---------RDGSSCLSSMEYYDPHTNKWNMCAP 632
Query: 478 MKYSKYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPL 537
M + A + +Y +GG + + LD VE Y+P D W P
Sbjct: 633 MCKRRGGVGVATCDGFLYAVGGHDAPASN--HCSRLLDYVERYDPKTDTWTMVAP----- 685
Query: 538 LSLRTNSTNAGAVDGKLYVCGGFHGADRHEVISKEILELDPWENQWNVVA 587
LS+ ++ + +LY GG+ G + + DP N+W +A
Sbjct: 686 LSMPRDAVGVCLLGDRLYAVGGYDG----QTYLNTMESYDPQTNEWTQMA 731
Score = 47.8 bits (112), Expect = 3e-05
Identities = 43/187 (22%), Positives = 76/187 (40%), Gaps = 27/187 (14%)
Query: 301 YDPVSRKTYFISSPKYGEGLGTVCTGVVMENNTII-VAGEASASKLSRQKNKNVEIYRYH 359
+DP S++ F++S GV N + V G +S LS + Y+
Sbjct: 573 WDPQSQQWTFVASMSIARST----VGVAALNGKLYSVGGRDGSSCLSSME--------YY 620
Query: 360 DRGNQFWEKLCTAEFRELYALGSIHND--LYVIGGQMKIKNQYL--ITNCVDKYSVERDN 415
D W +C + +G D LY +GG + + + + V++Y + D
Sbjct: 621 DPHTNKWN-MCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDT 679
Query: 416 WKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVR 475
W V+PL + V + ++LY +GG+ Q L N + YDP ++W+
Sbjct: 680 WTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYL---------NTMESYDPQTNEWTQM 730
Query: 476 APMKYSK 482
A + +
Sbjct: 731 ASLNIGR 737
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 176 bits (447), Expect = 4e-44
Identities = 145/595 (24%), Positives = 253/595 (42%), Gaps = 85/595 (14%)
Query: 12 QHSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQRE 71
+H+ +L +I M+ DV L E F HRLVLAA SPYF A+FT G+ E ++
Sbjct: 18 KHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDV 77
Query: 72 VILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDAS 131
V + I A +LL+++Y + I NVQ + +AA +Q+ EV +C +++ +D
Sbjct: 78 VPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPL 137
Query: 132 NCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISRE 191
NC+GI+ F++QI DL + S+ Y++ HF EV EE L + Q + +++S++L+I E
Sbjct: 138 NCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDE 197
Query: 192 ESILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQ 251
+ ++W+ + R H+VE+L +R L+ P L + + + +++
Sbjct: 198 YQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLK 257
Query: 252 NAFKAIKTPQQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSRKTYFI 311
+ K+P+++ C +S +R R +
Sbjct: 258 EYCEVCKSPKENK-------------FCSFLQTSKVRPRKK------------------- 285
Query: 312 SSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEKLCT 371
+ KY +G T + G S S+ + D +Q+W + +
Sbjct: 286 -ARKYLYAVG---------GYTRLQGGRWSDSRA-------LSCVERFDTFSQYWTTVSS 328
Query: 372 A-EFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHA 430
+ R + + +Y IGG+ +I +C + Y W V+ +
Sbjct: 329 LHQARSGLGVTVLGGMVYAIGGE----KDSMIFDCTECYDPVTKQWTTVASMNHPRCGLG 384
Query: 431 VVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVV 490
V +Y +GGW + N + ++DP +++W V M S+Y F +
Sbjct: 385 VCVCYGAIYALGGWVGA---------EIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEM 435
Query: 491 NSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGAV 550
IYV+GGI G + L E+Y+P W PPM R A+
Sbjct: 436 QGLIYVIGGISNEGIE-------LRSFEVYDPLSKRWSPLPPM-----GTRRAYLGVAAL 483
Query: 551 DGKLYVCGGFHGA-DRHEVISKEILELDPWENQWN---------VVAINVLMHDS 595
+ +Y GG++ D + K E + W + VVA+N L++ S
Sbjct: 484 NDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVS 538
Score = 53.9 bits (128), Expect = 4e-07
Identities = 51/207 (24%), Positives = 86/207 (41%), Gaps = 27/207 (13%)
Query: 296 DASFCYDPVSRKTYFISSPKYGE-GLGT-VCTGVVMENNTIIVAGEASASKLSRQKNKNV 353
D + CYDPV+++ ++S + GLG VC G + A + + +
Sbjct: 358 DCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIY----------ALGGWVGAEIGNTI 407
Query: 354 EIYRYHDRGNQFWEKLCT-AEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVE 412
E + D WE + A R + + +YVIGG I N+ + + Y
Sbjct: 408 ERF---DPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGG---ISNEGIELRSFEVYDPL 461
Query: 413 RDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQW 472
W + P+ + A V +N+ +Y +GGW +E D L + + +Y +++W
Sbjct: 462 SKRWSPLPPMGTRRAYLGVAALNDCIYSVGGW-------NETQDAL-HTVEKYSFEEEKW 513
Query: 473 SVRAPMKYSKYRFSTAVVNSEIYVLGG 499
A MK + VN +YV GG
Sbjct: 514 VEVASMKVPRAGMCVVAVNGLLYVSGG 540
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 174 bits (442), Expect = 2e-43
Identities = 145/569 (25%), Positives = 236/569 (41%), Gaps = 54/569 (9%)
Query: 26 ELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREVILYDITAESVSVL 85
E E+ DV L + CH+LVLA PYF+AMF + E Q + + D +++ L
Sbjct: 62 ENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDL 121
Query: 86 LNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASNCLGIYYFAKQIGA 145
+ ++Y++ L + NVQ + AA +Q+E V C +YM H SNCL + FA+
Sbjct: 122 VKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNR 181
Query: 146 EDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREESILDLVLRWVNHN 205
DL D + +Y HF EV E+ + + L+ S DLNI E+ + + ++W+ N
Sbjct: 182 IDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLAN 241
Query: 206 KELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQNA------FKAIKT 259
+ + L E L QVRL L+ FL + + ++ + C D++ A +
Sbjct: 242 PQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAV 301
Query: 260 PQ-QHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSRKTYFISSPKYGE 318
P ++S+ T +L C+G G RS CY +++ ++F P+
Sbjct: 302 PDFEYSIRTTPRKHTAGVLFCVGGR-GGSGDPFRSIE----CYS-INKNSWFF-GPEMNS 354
Query: 319 GLGTVCTGVV-MENNTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEKLCTAEFREL 377
V GV+ +E V G L + + N++ K R
Sbjct: 355 RRRHV--GVISVEGKVYAVGGHDGNEHLGSME-------MFDPLTNKWMMKASMNTKRRG 405
Query: 378 YALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNK 437
AL S+ +Y IGG + N V++Y +E D W V+P+ V + N
Sbjct: 406 IALASLGGPIYAIGG----LDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNH 461
Query: 438 LYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVL 497
+Y +GG L E +YDP D+W M + + ++ +YV+
Sbjct: 462 VYAVGGNDGMASLSSVE---------RYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVV 512
Query: 498 GGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGAVDGKLYVC 557
GG L VE Y+P + W + +P V GK++
Sbjct: 513 GGF--------DDNSPLSSVERYDPRSNKWDYVAALTTP-----RGGVGIATVMGKIFAV 559
Query: 558 GGFHGADRHEVISKEILELDPWENQWNVV 586
GG +G + DP N+W +V
Sbjct: 560 GGHNG----NAYLNTVEAFDPVLNRWELV 584
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 174 bits (440), Expect = 3e-43
Identities = 139/554 (25%), Positives = 242/554 (43%), Gaps = 35/554 (6%)
Query: 13 HSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREV 72
HS +LL + ++ +++DVVLT E FP H++VLAA S YF+AMFT G+ E +Q +
Sbjct: 45 HSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVI 104
Query: 73 ILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASN 132
L ++A + ++++ Y+A + ++ VQ V AA F+QM V +C++++ M
Sbjct: 105 ELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVET 164
Query: 133 CLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREE 192
CL I A L + + ++HF +++ E+ L + + + + ++S+ L E
Sbjct: 165 CLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEI 224
Query: 193 SILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQN 252
+ +RW+ H+ R +L +R L+ S L +++ +++ D C +
Sbjct: 225 DLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLLE 283
Query: 253 AFKAIKTP-QQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSRKTYFI 311
AF P +QH + + + + + RS + P +F
Sbjct: 284 AFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQL-PEPGARHFR 342
Query: 312 SSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEKLCT 371
+ G C V+ +N + VAG S + + YRY N++
Sbjct: 343 ELTEMEVGCSHTCVAVL--DNFVYVAGGQHLQYRSGEGAVDA-CYRYDPHLNRWLRLQAM 399
Query: 372 AEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAV 431
E R + L + +Y GG +N+ V++Y R+ W L + HA
Sbjct: 400 QESRIQFQLNVLCGMVYATGG----RNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAG 455
Query: 432 VTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVN 491
+LY+ GG+ + + D++ L YDP DQW +APM + +
Sbjct: 456 AASGGRLYISGGY--GISVEDKK------ALHCYDPVADQWEFKAPMSEPRVLHAMVGAG 507
Query: 492 SEIYVLGGIGCVGQDKGQVRKCLDV--VEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGA 549
IY LGG V +C DV VE Y P+ D W PM R + AG
Sbjct: 508 GRIYALGG------RMDHVDRCFDVLAVEYYVPETDQWTSVSPM-------RAGQSEAGC 554
Query: 550 --VDGKLYVCGGFH 561
++ K+Y+ GG++
Sbjct: 555 CLLERKIYIVGGYN 568
>gi|156616301 kelch-like 32 [Homo sapiens]
Length = 620
Score = 170 bits (431), Expect = 3e-42
Identities = 134/561 (23%), Positives = 250/561 (44%), Gaps = 42/561 (7%)
Query: 13 HSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREV 72
H+ ++L + + + D+ L AE +KF H+ VLAA S YF+AMF+ ++E EV
Sbjct: 24 HNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADEV 83
Query: 73 ILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASN 132
L+ +T+ + L + Y + + +Q V A +Q+ E+ ++C Y++ +++ N
Sbjct: 84 NLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFN 143
Query: 133 CLGIYYFAKQIGAEDLSDRSKKYLYQHFAEV--SLHEEILEIEVHQFLTLIKSDDLNISR 190
L +Y A L +L +H +E+ S EE+L + ++KSD L
Sbjct: 144 YLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLS 203
Query: 191 EESILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDII 250
EE I L +RW+ HN + ++ ELL+ +R L++ L + ++ ++
Sbjct: 204 EEQIWQLAVRWLEHNCHYQ--YMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALV 261
Query: 251 QNAFKAIKT----PQQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSR 306
A + ++ P + + ++ +L + G + + Y ++PV +
Sbjct: 262 NEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRY------FNPVDQ 315
Query: 307 KTYFISSPKYGEGLGTVCTG-----VVMENNTIIVAGEASASKLSRQKNKNVEIYRYHDR 361
+ I++ L + G V + + + VAG S + RY R
Sbjct: 316 ENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAG-GEVEHASGRTCAVRTACRYDPR 374
Query: 362 GNQFWEKLCTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSP 421
N + E RE + LG++ LY +GG+ +++ + V++Y +++ W V
Sbjct: 375 SNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQ---VLPTVERYCPKKNKWTFVQS 431
Query: 422 LPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYS 481
L+CHA + L++ GG T + N+L+ Y+P+Q++W R+PM
Sbjct: 432 FDRSLSCHAGYVADGLLWISGGVT--------NTAQYQNRLMVYEPNQNKWISRSPMLQR 483
Query: 482 KYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLR 541
+ S A V ++YVLGG D R + ++ YN D D W +L
Sbjct: 484 RVYHSMAAVQRKLYVLGGNDL---DYNNDRILVRHIDSYNIDTDQWTRCN------FNLL 534
Query: 542 TNSTNAGAV--DGKLYVCGGF 560
T +G +G++Y+ GG+
Sbjct: 535 TGQNESGVAVHNGRIYLVGGY 555
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 170 bits (430), Expect = 4e-42
Identities = 143/588 (24%), Positives = 252/588 (42%), Gaps = 59/588 (10%)
Query: 13 HSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQR-- 70
H +L ++ + D+ + EG +F H+ VLA+ S YFK + + + Q
Sbjct: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
Query: 71 ---EVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDH 127
E++L ++ A+ + +LL ++Y +L I++AN +T+ AA Q VC ++
Sbjct: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
Query: 128 MDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLN 187
+ ASNCLG+ A+ + +L +K + Q F EV+ EEIL I F+ + +D LN
Sbjct: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
Query: 188 ISREESILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCV 247
EE + + V++W+ + RT + ELL VRL ++PS+L + ++ C
Sbjct: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
Query: 248 DIIQNAFKAIKTP------QQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCY 301
D++ A + P Q R +++ +G + RS A C+
Sbjct: 551 DLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQM-VGMTQRSL-VAVTCW 608
Query: 302 DPVSRKTYFISS-PKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHD 360
+P + K Y ++S P Y +V V +N + G S L+ +++ Y
Sbjct: 609 NPQNNKWYPLASLPFYDREFFSV---VSAGDNIYLSGGMESGVTLA-------DVWCYMS 658
Query: 361 RGNQFWEKLCTAEFRELYALGSIHN-DLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRV 419
+ W + +++ +Y +GG N + V++Y + W+ V
Sbjct: 659 LLDN-WNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGN----VDHVERYDTITNQWEAV 713
Query: 420 SPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWS-VRAPM 478
+PLP + A K+YV GG E R + L Y P + WS + +PM
Sbjct: 714 APLPKAVHSAAATVCGGKIYVFGG--------VNEAGRAAGVLQSYVPQTNTWSFIESPM 765
Query: 479 KYSKYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLL 538
+KY +N +++LGG IY+P+ + GP M
Sbjct: 766 IDNKYA-PAVTLNGFVFILGG------------AYARATTIYDPEKGNIKAGPNM----- 807
Query: 539 SLRTNSTNAGAVDGKLYVCGGFHGADRHEVISKEILELDPWENQWNVV 586
+ +A +DGK+Y GG ++ + + E E P N W ++
Sbjct: 808 NHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYE--PTTNTWTLL 853
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,377,369
Number of Sequences: 37866
Number of extensions: 1021986
Number of successful extensions: 3142
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 157
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 2164
Number of HSP's gapped (non-prelim): 401
length of query: 623
length of database: 18,247,518
effective HSP length: 108
effective length of query: 515
effective length of database: 14,157,990
effective search space: 7291364850
effective search space used: 7291364850
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.