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Search of human proteins with 82617560
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|82617560 endothelin converting enzyme 2 isoform B [Homo
sapiens]
(736 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|82617560 endothelin converting enzyme 2 isoform B [Homo sapiens] 1497 0.0
gi|153945836 endothelin converting enzyme 2 isoform E [Homo sapi... 1482 0.0
gi|153945761 endothelin converting enzyme 2 isoform A [Homo sapi... 1474 0.0
gi|153945771 endothelin converting enzyme 2 isoform D [Homo sapi... 1473 0.0
gi|164519140 endothelin converting enzyme 1 isoform 2 [Homo sapi... 984 0.0
gi|164519138 endothelin converting enzyme 1 isoform 4 [Homo sapi... 984 0.0
gi|164519136 endothelin converting enzyme 1 isoform 3 [Homo sapi... 984 0.0
gi|4503443 endothelin converting enzyme 1 isoform 1 [Homo sapiens] 984 0.0
gi|239049391 membrane metallo-endopeptidase-like 1 [Homo sapiens] 548 e-156
gi|157426891 endothelin converting enzyme-like 1 [Homo sapiens] 529 e-150
gi|116256333 membrane metallo-endopeptidase [Homo sapiens] 487 e-137
gi|116256331 membrane metallo-endopeptidase [Homo sapiens] 487 e-137
gi|116256327 membrane metallo-endopeptidase [Homo sapiens] 487 e-137
gi|116256329 membrane metallo-endopeptidase [Homo sapiens] 487 e-137
gi|90403592 phosphate-regulating neutral endopeptidase [Homo sap... 461 e-129
gi|4557691 Kell blood group, metallo-endopeptidase [Homo sapiens] 359 4e-99
gi|124487387 ring finger protein 207 [Homo sapiens] 33 1.2
gi|239753431 PREDICTED: similar to endothelin converting enzyme-... 32 2.1
gi|239747995 PREDICTED: hypothetical protein XP_002346505 [Homo ... 32 2.1
gi|239741893 PREDICTED: hypothetical protein XP_002342317 [Homo ... 32 2.1
gi|20544129 DEAH (Asp-Glu-Ala-His) box polypeptide 35 [Homo sapi... 31 3.6
gi|83641876 serine carboxypeptidase vitellogenic-like [Homo sapi... 30 8.0
gi|83641874 serine carboxypeptidase vitellogenic-like [Homo sapi... 30 8.0
gi|148234215 guanylate binding protein 4-like [Homo sapiens] 30 8.0
>gi|82617560 endothelin converting enzyme 2 isoform B [Homo sapiens]
Length = 736
Score = 1497 bits (3876), Expect = 0.0
Identities = 736/736 (100%), Positives = 736/736 (100%)
Query: 1 MNVALQELGAGSNVGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDP 60
MNVALQELGAGSNVGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDP
Sbjct: 1 MNVALQELGAGSNVGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDP 60
Query: 61 SHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWD 120
SHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWD
Sbjct: 61 SHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWD 120
Query: 121 QNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITG 180
QNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITG
Sbjct: 121 QNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITG 180
Query: 181 PWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTA 240
PWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTA
Sbjct: 181 PWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTA 240
Query: 241 NEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKM 300
NEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKM
Sbjct: 241 NEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKM 300
Query: 301 SISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYL 360
SISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYL
Sbjct: 301 SISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYL 360
Query: 361 IWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKA 420
IWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKA
Sbjct: 361 IWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKA 420
Query: 421 TFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPK 480
TFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPK
Sbjct: 421 TFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPK 480
Query: 481 ELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKN 540
ELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKN
Sbjct: 481 ELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKN 540
Query: 541 EIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNES 600
EIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNES
Sbjct: 541 EIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNES 600
Query: 601 LAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQ 660
LAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQ
Sbjct: 601 LAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQ 660
Query: 661 LPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFG 720
LPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFG
Sbjct: 661 LPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFG 720
Query: 721 CPVGSPMNPGQLCEVW 736
CPVGSPMNPGQLCEVW
Sbjct: 721 CPVGSPMNPGQLCEVW 736
>gi|153945836 endothelin converting enzyme 2 isoform E [Homo
sapiens]
Length = 765
Score = 1482 bits (3836), Expect = 0.0
Identities = 736/765 (96%), Positives = 736/765 (96%), Gaps = 29/765 (3%)
Query: 1 MNVALQELGAGSN-----------------------------VGFQKGTRQLLGSRTQLE 31
MNVALQELGAGSN VGFQKGTRQLLGSRTQLE
Sbjct: 1 MNVALQELGAGSNMVEYKRATLRDEDAPETPVEGGASPDAMEVGFQKGTRQLLGSRTQLE 60
Query: 32 LVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDF 91
LVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDF
Sbjct: 61 LVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDF 120
Query: 92 YQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLS 151
YQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLS
Sbjct: 121 YQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLS 180
Query: 152 CLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISAD 211
CLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISAD
Sbjct: 181 CLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISAD 240
Query: 212 SKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQ 271
SKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQ
Sbjct: 241 SKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQ 300
Query: 272 QVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSE 331
QVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSE
Sbjct: 301 QVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSE 360
Query: 332 PVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTK 391
PVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTK
Sbjct: 361 PVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTK 420
Query: 392 KSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWM 451
KSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWM
Sbjct: 421 KSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWM 480
Query: 452 DEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVM 511
DEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVM
Sbjct: 481 DEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVM 540
Query: 512 ADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVM 571
ADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVM
Sbjct: 541 ADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVM 600
Query: 572 GHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTL 631
GHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTL
Sbjct: 601 GHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTL 660
Query: 632 GENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHE 691
GENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHE
Sbjct: 661 GENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHE 720
Query: 692 GLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 736
GLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW
Sbjct: 721 GLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 765
>gi|153945761 endothelin converting enzyme 2 isoform A [Homo
sapiens]
Length = 883
Score = 1474 bits (3817), Expect = 0.0
Identities = 724/725 (99%), Positives = 724/725 (99%)
Query: 12 SNVGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACI 71
S VGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACI
Sbjct: 159 SEVGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACI 218
Query: 72 RVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLE 131
RVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLE
Sbjct: 219 RVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLE 278
Query: 132 NTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVL 191
NTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVL
Sbjct: 279 NTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVL 338
Query: 192 KAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDY 251
KAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDY
Sbjct: 339 KAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDY 398
Query: 252 MEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPS 311
MEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPS
Sbjct: 399 MEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPS 458
Query: 312 MDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSS 371
MDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSS
Sbjct: 459 MDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSS 518
Query: 372 LDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAE 431
LDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAE
Sbjct: 519 LDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAE 578
Query: 432 GMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEI 491
GMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEI
Sbjct: 579 GMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEI 638
Query: 492 SEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQA 551
SEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQA
Sbjct: 639 SEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQA 698
Query: 552 PFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACM 611
PFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACM
Sbjct: 699 PFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACM 758
Query: 612 EEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQL 671
EEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQL
Sbjct: 759 EEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQL 818
Query: 672 FFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQ 731
FFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQ
Sbjct: 819 FFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQ 878
Query: 732 LCEVW 736
LCEVW
Sbjct: 879 LCEVW 883
>gi|153945771 endothelin converting enzyme 2 isoform D [Homo
sapiens]
Length = 811
Score = 1473 bits (3813), Expect = 0.0
Identities = 723/723 (100%), Positives = 723/723 (100%)
Query: 14 VGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRV 73
VGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRV
Sbjct: 89 VGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRV 148
Query: 74 AGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENT 133
AGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENT
Sbjct: 149 AGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENT 208
Query: 134 TFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKA 193
TFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKA
Sbjct: 209 TFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKA 268
Query: 194 VAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYME 253
VAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYME
Sbjct: 269 VAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYME 328
Query: 254 ELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMD 313
ELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMD
Sbjct: 329 ELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMD 388
Query: 314 WLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLD 373
WLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLD
Sbjct: 389 WLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLD 448
Query: 374 RRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGM 433
RRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGM
Sbjct: 449 RRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGM 508
Query: 434 ISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISE 493
ISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISE
Sbjct: 509 ISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISE 568
Query: 494 DSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPF 553
DSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPF
Sbjct: 569 DSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPF 628
Query: 554 YARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEE 613
YARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEE
Sbjct: 629 YARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEE 688
Query: 614 QYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFF 673
QYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFF
Sbjct: 689 QYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFF 748
Query: 674 VGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLC 733
VGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLC
Sbjct: 749 VGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLC 808
Query: 734 EVW 736
EVW
Sbjct: 809 EVW 811
>gi|164519140 endothelin converting enzyme 1 isoform 2 [Homo
sapiens]
Length = 767
Score = 984 bits (2544), Expect = 0.0
Identities = 462/712 (64%), Positives = 577/712 (81%), Gaps = 3/712 (0%)
Query: 26 SRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGV 85
+RTQ+E L +LLAA L+ CL ALG+QY + S S CL+EAC+ V IL S+D V
Sbjct: 58 ARTQVEKRLVVLVVLLAAGLVACLAALGIQY-QTRSPSVCLSEACVSVTSSILSSMDPTV 116
Query: 86 SPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKT 145
PC DF+ ++CGGWI+ NP+PDG SRW TF++LW+ NQAI+KHLLEN+T S SEAE+K
Sbjct: 117 DPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA-SVSEAERKA 175
Query: 146 QRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFT 205
Q +Y +C+ RIEEL A+PL +LIE++GGWNITGPW +DNF + L+ V YR +PFF+
Sbjct: 176 QVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFS 235
Query: 206 VYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTS 265
VY+SADSK+SNSNVIQVDQSGL LPSRDYYLN+T NEKVLT YL+YM +LG LLGG
Sbjct: 236 VYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEE 295
Query: 266 T-REQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSP 324
R QMQQ+L+ E LANIT+PQ++RRDEE IYHK++ +ELQ LAP+++WL FL+ + P
Sbjct: 296 AIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYP 355
Query: 325 LELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLL 384
+E+++SEP+VVY +YL+Q+S LIN T+ +LNNY+IWNLV+KT+S LD+RF+ A EK +
Sbjct: 356 VEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFM 415
Query: 385 ETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEA 444
E +YGTKK+C+PRW+ C+S+T++ LGFALG +FVKATF SK IA +I EI+ AFEE+
Sbjct: 416 EVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEES 475
Query: 445 LGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLY 504
L L WMDE+TR++AKEKADAIY+MIG+P+FI++PKELD V++ Y D +F+N + +
Sbjct: 476 LSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF 535
Query: 505 NFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNF 564
NFS +V ADQLRK P+RDQWSMTP VNAYY PTKNEIVFPAGILQAPFY R+ PKALNF
Sbjct: 536 NFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNF 595
Query: 565 GGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGER 624
GGIGVV+GHELTHAFDDQGREYDK+GNLRPWW+N S+ AF+ T CM EQY+ Y VNGE
Sbjct: 596 GGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEP 655
Query: 625 LNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVR 684
+NGR TLGENIADNGGLKAAY AY+ W++K+G E LP +GLTN+QLFF+GFAQVWCSVR
Sbjct: 656 VNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVR 715
Query: 685 TPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 736
TPESSHEGL+TDPHSP+RFRV+G+LSNS++F HF CP GSPMNP CEVW
Sbjct: 716 TPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 767
>gi|164519138 endothelin converting enzyme 1 isoform 4 [Homo
sapiens]
Length = 754
Score = 984 bits (2544), Expect = 0.0
Identities = 462/712 (64%), Positives = 577/712 (81%), Gaps = 3/712 (0%)
Query: 26 SRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGV 85
+RTQ+E L +LLAA L+ CL ALG+QY + S S CL+EAC+ V IL S+D V
Sbjct: 45 ARTQVEKRLVVLVVLLAAGLVACLAALGIQY-QTRSPSVCLSEACVSVTSSILSSMDPTV 103
Query: 86 SPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKT 145
PC DF+ ++CGGWI+ NP+PDG SRW TF++LW+ NQAI+KHLLEN+T S SEAE+K
Sbjct: 104 DPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA-SVSEAERKA 162
Query: 146 QRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFT 205
Q +Y +C+ RIEEL A+PL +LIE++GGWNITGPW +DNF + L+ V YR +PFF+
Sbjct: 163 QVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFS 222
Query: 206 VYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTS 265
VY+SADSK+SNSNVIQVDQSGL LPSRDYYLN+T NEKVLT YL+YM +LG LLGG
Sbjct: 223 VYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEE 282
Query: 266 T-REQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSP 324
R QMQQ+L+ E LANIT+PQ++RRDEE IYHK++ +ELQ LAP+++WL FL+ + P
Sbjct: 283 AIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYP 342
Query: 325 LELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLL 384
+E+++SEP+VVY +YL+Q+S LIN T+ +LNNY+IWNLV+KT+S LD+RF+ A EK +
Sbjct: 343 VEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFM 402
Query: 385 ETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEA 444
E +YGTKK+C+PRW+ C+S+T++ LGFALG +FVKATF SK IA +I EI+ AFEE+
Sbjct: 403 EVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEES 462
Query: 445 LGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLY 504
L L WMDE+TR++AKEKADAIY+MIG+P+FI++PKELD V++ Y D +F+N + +
Sbjct: 463 LSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF 522
Query: 505 NFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNF 564
NFS +V ADQLRK P+RDQWSMTP VNAYY PTKNEIVFPAGILQAPFY R+ PKALNF
Sbjct: 523 NFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNF 582
Query: 565 GGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGER 624
GGIGVV+GHELTHAFDDQGREYDK+GNLRPWW+N S+ AF+ T CM EQY+ Y VNGE
Sbjct: 583 GGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEP 642
Query: 625 LNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVR 684
+NGR TLGENIADNGGLKAAY AY+ W++K+G E LP +GLTN+QLFF+GFAQVWCSVR
Sbjct: 643 VNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVR 702
Query: 685 TPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 736
TPESSHEGL+TDPHSP+RFRV+G+LSNS++F HF CP GSPMNP CEVW
Sbjct: 703 TPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 754
>gi|164519136 endothelin converting enzyme 1 isoform 3 [Homo
sapiens]
Length = 758
Score = 984 bits (2544), Expect = 0.0
Identities = 462/712 (64%), Positives = 577/712 (81%), Gaps = 3/712 (0%)
Query: 26 SRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGV 85
+RTQ+E L +LLAA L+ CL ALG+QY + S S CL+EAC+ V IL S+D V
Sbjct: 49 ARTQVEKRLVVLVVLLAAGLVACLAALGIQY-QTRSPSVCLSEACVSVTSSILSSMDPTV 107
Query: 86 SPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKT 145
PC DF+ ++CGGWI+ NP+PDG SRW TF++LW+ NQAI+KHLLEN+T S SEAE+K
Sbjct: 108 DPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA-SVSEAERKA 166
Query: 146 QRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFT 205
Q +Y +C+ RIEEL A+PL +LIE++GGWNITGPW +DNF + L+ V YR +PFF+
Sbjct: 167 QVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFS 226
Query: 206 VYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTS 265
VY+SADSK+SNSNVIQVDQSGL LPSRDYYLN+T NEKVLT YL+YM +LG LLGG
Sbjct: 227 VYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEE 286
Query: 266 T-REQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSP 324
R QMQQ+L+ E LANIT+PQ++RRDEE IYHK++ +ELQ LAP+++WL FL+ + P
Sbjct: 287 AIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYP 346
Query: 325 LELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLL 384
+E+++SEP+VVY +YL+Q+S LIN T+ +LNNY+IWNLV+KT+S LD+RF+ A EK +
Sbjct: 347 VEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFM 406
Query: 385 ETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEA 444
E +YGTKK+C+PRW+ C+S+T++ LGFALG +FVKATF SK IA +I EI+ AFEE+
Sbjct: 407 EVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEES 466
Query: 445 LGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLY 504
L L WMDE+TR++AKEKADAIY+MIG+P+FI++PKELD V++ Y D +F+N + +
Sbjct: 467 LSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF 526
Query: 505 NFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNF 564
NFS +V ADQLRK P+RDQWSMTP VNAYY PTKNEIVFPAGILQAPFY R+ PKALNF
Sbjct: 527 NFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNF 586
Query: 565 GGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGER 624
GGIGVV+GHELTHAFDDQGREYDK+GNLRPWW+N S+ AF+ T CM EQY+ Y VNGE
Sbjct: 587 GGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEP 646
Query: 625 LNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVR 684
+NGR TLGENIADNGGLKAAY AY+ W++K+G E LP +GLTN+QLFF+GFAQVWCSVR
Sbjct: 647 VNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVR 706
Query: 685 TPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 736
TPESSHEGL+TDPHSP+RFRV+G+LSNS++F HF CP GSPMNP CEVW
Sbjct: 707 TPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 758
>gi|4503443 endothelin converting enzyme 1 isoform 1 [Homo sapiens]
Length = 770
Score = 984 bits (2544), Expect = 0.0
Identities = 462/712 (64%), Positives = 577/712 (81%), Gaps = 3/712 (0%)
Query: 26 SRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGV 85
+RTQ+E L +LLAA L+ CL ALG+QY + S S CL+EAC+ V IL S+D V
Sbjct: 61 ARTQVEKRLVVLVVLLAAGLVACLAALGIQY-QTRSPSVCLSEACVSVTSSILSSMDPTV 119
Query: 86 SPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKT 145
PC DF+ ++CGGWI+ NP+PDG SRW TF++LW+ NQAI+KHLLEN+T S SEAE+K
Sbjct: 120 DPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA-SVSEAERKA 178
Query: 146 QRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFT 205
Q +Y +C+ RIEEL A+PL +LIE++GGWNITGPW +DNF + L+ V YR +PFF+
Sbjct: 179 QVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFS 238
Query: 206 VYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTS 265
VY+SADSK+SNSNVIQVDQSGL LPSRDYYLN+T NEKVLT YL+YM +LG LLGG
Sbjct: 239 VYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEE 298
Query: 266 T-REQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSP 324
R QMQQ+L+ E LANIT+PQ++RRDEE IYHK++ +ELQ LAP+++WL FL+ + P
Sbjct: 299 AIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYP 358
Query: 325 LELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLL 384
+E+++SEP+VVY +YL+Q+S LIN T+ +LNNY+IWNLV+KT+S LD+RF+ A EK +
Sbjct: 359 VEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFM 418
Query: 385 ETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEA 444
E +YGTKK+C+PRW+ C+S+T++ LGFALG +FVKATF SK IA +I EI+ AFEE+
Sbjct: 419 EVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEES 478
Query: 445 LGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLY 504
L L WMDE+TR++AKEKADAIY+MIG+P+FI++PKELD V++ Y D +F+N + +
Sbjct: 479 LSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF 538
Query: 505 NFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNF 564
NFS +V ADQLRK P+RDQWSMTP VNAYY PTKNEIVFPAGILQAPFY R+ PKALNF
Sbjct: 539 NFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNF 598
Query: 565 GGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGER 624
GGIGVV+GHELTHAFDDQGREYDK+GNLRPWW+N S+ AF+ T CM EQY+ Y VNGE
Sbjct: 599 GGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEP 658
Query: 625 LNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVR 684
+NGR TLGENIADNGGLKAAY AY+ W++K+G E LP +GLTN+QLFF+GFAQVWCSVR
Sbjct: 659 VNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVR 718
Query: 685 TPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 736
TPESSHEGL+TDPHSP+RFRV+G+LSNS++F HF CP GSPMNP CEVW
Sbjct: 719 TPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 770
>gi|239049391 membrane metallo-endopeptidase-like 1 [Homo sapiens]
Length = 779
Score = 548 bits (1412), Expect = e-156
Identities = 298/757 (39%), Positives = 429/757 (56%), Gaps = 56/757 (7%)
Query: 34 LAGASLLLAALLLGCLVALGVQY-------------------------HRDPS------- 61
L G LLL L+ LVALGV Y R P
Sbjct: 25 LEGGLLLLLLLVTAALVALGVLYADRRGKQLPRLASRLCFLQEERTFVKRKPRGIPEAQE 84
Query: 62 -HSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWD 120
C T C+ A +IL+++D PC+DFYQF+CGGW+RR+ +P+ SR++ F+ L D
Sbjct: 85 VSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDVLRD 144
Query: 121 QNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNIT- 179
+ + ILK +LEN+T E K + Y SC+ IE+ G+QPL D++E +GGW +
Sbjct: 145 ELEVILKAVLENSTAKDRPAVE-KARTLYRSCMNQSVIEKRGSQPLLDILEVVGGWPVAM 203
Query: 180 GPWDQDNFME-----VLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDY 234
W++ +E L + + ++I D ++S+ ++I +DQ L +PSR+Y
Sbjct: 204 DRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREY 263
Query: 235 YLNRTANEKVLTAYLDYMEELGMLLGGRPTSTR------EQMQQVLELEIQLANITVPQD 288
Y N +N KV AYL +M + LL R E M QVLELE QLA TVPQ+
Sbjct: 264 YFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQE 323
Query: 289 QRRDEEKIYHKMSISELQAL--APSMDWLEFLSFLLSP--LELSDSEPVVVYGMDYLQQV 344
+R D +YH+M + ELQ+ +W F+ +LS ++L E VVVYG+ YLQ +
Sbjct: 324 ERHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNL 383
Query: 345 SELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISN 404
+I+ + NYL+W LV SL +RF+ + + L+GT V RW+ C+
Sbjct: 384 ENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEV-RWRECVGY 442
Query: 405 TDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKAD 464
+ + A+GSL+V+ F SK + +I ++RT F E L +L WMDE++++ A+EKA
Sbjct: 443 VNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEESKKKAQEKAM 502
Query: 465 AIYDMIGFPDFILEP--KELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRD 522
+I + IG PD+ILE + LD+ Y SED +F+N L A+ +LR+ +
Sbjct: 503 SIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENSLQNLKVGAQRSLRKLREKVDPN 562
Query: 523 QWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQ 582
W + VNA+Y P +N+IVFPAGILQ PF+++ P+ALNFGGIG+V+GHE+TH FDD
Sbjct: 563 LWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGFDDN 622
Query: 583 GREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQ---VNGERLNGRQTLGENIADNG 639
GR +DK GN+ WW N S FR + CM QY Y + + +NG TLGENIADNG
Sbjct: 623 GRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSWDLADEQNVNGFNTLGENIADNG 682
Query: 640 GLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHS 699
G++ AY AY W+ + G++QQLP + LT+ QLFF+ +AQVWC PE + + + TD HS
Sbjct: 683 GVRQAYKAYLKWMAEGGKDQQLPGLDLTHEQLFFINYAQVWCGSYRPEFAIQSIKTDVHS 742
Query: 700 PARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 736
P ++RVLG+L N F F C G+PM+P + C VW
Sbjct: 743 PLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW 779
>gi|157426891 endothelin converting enzyme-like 1 [Homo sapiens]
Length = 775
Score = 529 bits (1362), Expect = e-150
Identities = 267/681 (39%), Positives = 408/681 (59%), Gaps = 20/681 (2%)
Query: 68 EACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILK 127
+A R A + +LD + PC+DFY F+CGGW+RR+ +PD + + T ++ +QN+ L+
Sbjct: 103 KAFARAARFLAANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLR 162
Query: 128 HLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGP------ 181
LL A++K + F+ SCL + IE LG +P+ ++IE GGW++ G
Sbjct: 163 RLLARPGGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAEERPGV 222
Query: 182 ---WDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNR 238
WD + +L G Y A F++ +S D ++S+ VI++DQ GL LP R YL +
Sbjct: 223 AARWDLNR---LLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQ 279
Query: 239 TAN-EKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQ--DQRRDEEK 295
+ EK+L AY +ME + LLG + ++ Q++L++E QLANITV + D RRD
Sbjct: 280 DEDSEKILAAYRVFMERVLSLLGA--DAVEQKAQEILQVEQQLANITVSEHDDLRRDVSS 337
Query: 296 IYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSI 355
+Y+K+++ +LQ + P + W L + + S+ E VV+ DY+QQVS+LI T +
Sbjct: 338 MYNKVTLGQLQKITPHLRWKWLLDQIFQE-DFSEEEEVVLLATDYMQQVSQLIRSTPHRV 396
Query: 356 LNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGS 415
L+NYL+W +V + L F A +L + + G+ K + C+ + G ALG+
Sbjct: 397 LHNYLVWRVVVVLSEHLSPPFREALHELAQEMEGSDKP-QELARVCLGQANRHFGMALGA 455
Query: 416 LFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDF 475
LFV F SK + ++ +I+ + L +L WMD +TR AA+ K + M+G+PDF
Sbjct: 456 LFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAETRAAARAKLQYMMVMVGYPDF 515
Query: 476 ILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYY 535
+L+P +D Y+ +E+ E ++F+N+LN FS ++ ++R+ + W + PQ +NAYY
Sbjct: 516 LLKPDAVDKEYE-FEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSTWLLPPQALNAYY 574
Query: 536 LPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPW 595
LP KN++VFPAGILQ Y + P++LN+GGIG ++GHELTH +DD G +YD+ GNL W
Sbjct: 575 LPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHW 634
Query: 596 WQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKH 655
W S + F C+ Y+ + V +R+NG+ TLGENIAD GGLK AY+AY+ W+R+H
Sbjct: 635 WTEASYSRFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKLAYHAYQKWVREH 694
Query: 656 GEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDF 715
G E LP + T+ QLFF+ FAQ WC R +S + ++TD H+P +RVLG++S +F
Sbjct: 695 GPEHPLPRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEF 754
Query: 716 LRHFGCPVGSPMNPGQLCEVW 736
R F CP SPMNP C VW
Sbjct: 755 GRAFHCPKDSPMNPAHKCSVW 775
>gi|116256333 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 487 bits (1254), Expect = e-137
Identities = 263/733 (35%), Positives = 412/733 (56%), Gaps = 31/733 (4%)
Query: 28 TQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSP 87
T LE+ L+ LLL + + ++AL Y C + CI+ A ++++++D P
Sbjct: 25 TPLEISLSVLVLLLTIIAV-TMIALYATY----DDGICKSSDCIKSAARLIQNMDATTEP 79
Query: 88 CEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQR 147
C DF++++CGGW++RN +P+ SR+ F+ L D+ + +LK +L+ A QK +
Sbjct: 80 CTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPK-TEDIVAVQKAKA 138
Query: 148 FYLSCLQVERIEELGAQPLRDLIEKIGGWNI-TGPWDQDNFME--VLKAVA---GTYRAT 201
Y SC+ I+ G +PL L+ I GW + T W+Q KA+A Y
Sbjct: 139 LYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKK 198
Query: 202 PFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGG 261
+++ D K+S ++VI +DQ L LPSRDYY ++ TAY+D+M + L+
Sbjct: 199 VLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQ 258
Query: 262 R---PTSTRE---QMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQ------ALA 309
P + +M +V+ELE ++AN T + R D +Y+KM+++++Q
Sbjct: 259 EERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEING 318
Query: 310 PSMDWLEFLSFLLSPLELS--DSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQK 367
WL F + ++S + +S + E VVVY +YL ++ ++ + L N + W +
Sbjct: 319 KPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMD 378
Query: 368 TTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSK 427
SSL R ++ ++ + LYGT W+ C + + + A+G L+V+A F +SK
Sbjct: 379 LVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAVGRLYVEAAFAGESK 437
Query: 428 EIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILE-PKELDDVY 486
+ E +I++IR F + L L WMD +T++ A+EKA AI + IG+PD I+ +L++ Y
Sbjct: 438 HVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEY 497
Query: 487 DGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPA 546
ED +F+N++ FS +LR+ +D+W VNA+Y +N+IVFPA
Sbjct: 498 LELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPA 557
Query: 547 GILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRN 606
GILQ PF++ +LN+GGIG+V+GHE+TH FDD GR ++K+G+L WW +S + F+
Sbjct: 558 GILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKE 617
Query: 607 HTACMEEQYNQYQ---VNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPA 663
+ CM QY + G+ LNG TLGENIADNGGL AY AY+ +++K+GEE+ LP
Sbjct: 618 QSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPG 677
Query: 664 VGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPV 723
+ L + QLFF+ FAQVWC PE + + TD HSP FR++GTL NS +F F C
Sbjct: 678 LDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRK 737
Query: 724 GSPMNPGQLCEVW 736
S MNP + C VW
Sbjct: 738 NSYMNPEKKCRVW 750
>gi|116256331 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 487 bits (1254), Expect = e-137
Identities = 263/733 (35%), Positives = 412/733 (56%), Gaps = 31/733 (4%)
Query: 28 TQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSP 87
T LE+ L+ LLL + + ++AL Y C + CI+ A ++++++D P
Sbjct: 25 TPLEISLSVLVLLLTIIAV-TMIALYATY----DDGICKSSDCIKSAARLIQNMDATTEP 79
Query: 88 CEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQR 147
C DF++++CGGW++RN +P+ SR+ F+ L D+ + +LK +L+ A QK +
Sbjct: 80 CTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPK-TEDIVAVQKAKA 138
Query: 148 FYLSCLQVERIEELGAQPLRDLIEKIGGWNI-TGPWDQDNFME--VLKAVA---GTYRAT 201
Y SC+ I+ G +PL L+ I GW + T W+Q KA+A Y
Sbjct: 139 LYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKK 198
Query: 202 PFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGG 261
+++ D K+S ++VI +DQ L LPSRDYY ++ TAY+D+M + L+
Sbjct: 199 VLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQ 258
Query: 262 R---PTSTRE---QMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQ------ALA 309
P + +M +V+ELE ++AN T + R D +Y+KM+++++Q
Sbjct: 259 EERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEING 318
Query: 310 PSMDWLEFLSFLLSPLELS--DSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQK 367
WL F + ++S + +S + E VVVY +YL ++ ++ + L N + W +
Sbjct: 319 KPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMD 378
Query: 368 TTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSK 427
SSL R ++ ++ + LYGT W+ C + + + A+G L+V+A F +SK
Sbjct: 379 LVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAVGRLYVEAAFAGESK 437
Query: 428 EIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILE-PKELDDVY 486
+ E +I++IR F + L L WMD +T++ A+EKA AI + IG+PD I+ +L++ Y
Sbjct: 438 HVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEY 497
Query: 487 DGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPA 546
ED +F+N++ FS +LR+ +D+W VNA+Y +N+IVFPA
Sbjct: 498 LELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPA 557
Query: 547 GILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRN 606
GILQ PF++ +LN+GGIG+V+GHE+TH FDD GR ++K+G+L WW +S + F+
Sbjct: 558 GILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKE 617
Query: 607 HTACMEEQYNQYQ---VNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPA 663
+ CM QY + G+ LNG TLGENIADNGGL AY AY+ +++K+GEE+ LP
Sbjct: 618 QSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPG 677
Query: 664 VGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPV 723
+ L + QLFF+ FAQVWC PE + + TD HSP FR++GTL NS +F F C
Sbjct: 678 LDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRK 737
Query: 724 GSPMNPGQLCEVW 736
S MNP + C VW
Sbjct: 738 NSYMNPEKKCRVW 750
>gi|116256327 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 487 bits (1254), Expect = e-137
Identities = 263/733 (35%), Positives = 412/733 (56%), Gaps = 31/733 (4%)
Query: 28 TQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSP 87
T LE+ L+ LLL + + ++AL Y C + CI+ A ++++++D P
Sbjct: 25 TPLEISLSVLVLLLTIIAV-TMIALYATY----DDGICKSSDCIKSAARLIQNMDATTEP 79
Query: 88 CEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQR 147
C DF++++CGGW++RN +P+ SR+ F+ L D+ + +LK +L+ A QK +
Sbjct: 80 CTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPK-TEDIVAVQKAKA 138
Query: 148 FYLSCLQVERIEELGAQPLRDLIEKIGGWNI-TGPWDQDNFME--VLKAVA---GTYRAT 201
Y SC+ I+ G +PL L+ I GW + T W+Q KA+A Y
Sbjct: 139 LYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKK 198
Query: 202 PFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGG 261
+++ D K+S ++VI +DQ L LPSRDYY ++ TAY+D+M + L+
Sbjct: 199 VLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQ 258
Query: 262 R---PTSTRE---QMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQ------ALA 309
P + +M +V+ELE ++AN T + R D +Y+KM+++++Q
Sbjct: 259 EERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEING 318
Query: 310 PSMDWLEFLSFLLSPLELS--DSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQK 367
WL F + ++S + +S + E VVVY +YL ++ ++ + L N + W +
Sbjct: 319 KPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMD 378
Query: 368 TTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSK 427
SSL R ++ ++ + LYGT W+ C + + + A+G L+V+A F +SK
Sbjct: 379 LVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAVGRLYVEAAFAGESK 437
Query: 428 EIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILE-PKELDDVY 486
+ E +I++IR F + L L WMD +T++ A+EKA AI + IG+PD I+ +L++ Y
Sbjct: 438 HVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEY 497
Query: 487 DGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPA 546
ED +F+N++ FS +LR+ +D+W VNA+Y +N+IVFPA
Sbjct: 498 LELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPA 557
Query: 547 GILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRN 606
GILQ PF++ +LN+GGIG+V+GHE+TH FDD GR ++K+G+L WW +S + F+
Sbjct: 558 GILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKE 617
Query: 607 HTACMEEQYNQYQ---VNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPA 663
+ CM QY + G+ LNG TLGENIADNGGL AY AY+ +++K+GEE+ LP
Sbjct: 618 QSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPG 677
Query: 664 VGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPV 723
+ L + QLFF+ FAQVWC PE + + TD HSP FR++GTL NS +F F C
Sbjct: 678 LDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRK 737
Query: 724 GSPMNPGQLCEVW 736
S MNP + C VW
Sbjct: 738 NSYMNPEKKCRVW 750
>gi|116256329 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 487 bits (1254), Expect = e-137
Identities = 263/733 (35%), Positives = 412/733 (56%), Gaps = 31/733 (4%)
Query: 28 TQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSP 87
T LE+ L+ LLL + + ++AL Y C + CI+ A ++++++D P
Sbjct: 25 TPLEISLSVLVLLLTIIAV-TMIALYATY----DDGICKSSDCIKSAARLIQNMDATTEP 79
Query: 88 CEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQR 147
C DF++++CGGW++RN +P+ SR+ F+ L D+ + +LK +L+ A QK +
Sbjct: 80 CTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPK-TEDIVAVQKAKA 138
Query: 148 FYLSCLQVERIEELGAQPLRDLIEKIGGWNI-TGPWDQDNFME--VLKAVA---GTYRAT 201
Y SC+ I+ G +PL L+ I GW + T W+Q KA+A Y
Sbjct: 139 LYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKK 198
Query: 202 PFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGG 261
+++ D K+S ++VI +DQ L LPSRDYY ++ TAY+D+M + L+
Sbjct: 199 VLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQ 258
Query: 262 R---PTSTRE---QMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQ------ALA 309
P + +M +V+ELE ++AN T + R D +Y+KM+++++Q
Sbjct: 259 EERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEING 318
Query: 310 PSMDWLEFLSFLLSPLELS--DSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQK 367
WL F + ++S + +S + E VVVY +YL ++ ++ + L N + W +
Sbjct: 319 KPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMD 378
Query: 368 TTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSK 427
SSL R ++ ++ + LYGT W+ C + + + A+G L+V+A F +SK
Sbjct: 379 LVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAVGRLYVEAAFAGESK 437
Query: 428 EIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILE-PKELDDVY 486
+ E +I++IR F + L L WMD +T++ A+EKA AI + IG+PD I+ +L++ Y
Sbjct: 438 HVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEY 497
Query: 487 DGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPA 546
ED +F+N++ FS +LR+ +D+W VNA+Y +N+IVFPA
Sbjct: 498 LELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPA 557
Query: 547 GILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRN 606
GILQ PF++ +LN+GGIG+V+GHE+TH FDD GR ++K+G+L WW +S + F+
Sbjct: 558 GILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKE 617
Query: 607 HTACMEEQYNQYQ---VNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPA 663
+ CM QY + G+ LNG TLGENIADNGGL AY AY+ +++K+GEE+ LP
Sbjct: 618 QSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPG 677
Query: 664 VGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPV 723
+ L + QLFF+ FAQVWC PE + + TD HSP FR++GTL NS +F F C
Sbjct: 678 LDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRK 737
Query: 724 GSPMNPGQLCEVW 736
S MNP + C VW
Sbjct: 738 NSYMNPEKKCRVW 750
>gi|90403592 phosphate-regulating neutral endopeptidase [Homo
sapiens]
Length = 749
Score = 461 bits (1186), Expect = e-129
Identities = 266/756 (35%), Positives = 412/756 (54%), Gaps = 34/756 (4%)
Query: 7 ELGAGSNVGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCL 66
E GS+V + G + G+R L +V G +L+L +L LV+ G+ CL
Sbjct: 2 EAETGSSV--ETGKKANRGTRIAL-VVFVGGTLVLGTILF--LVSQGL-LSLQAKQEYCL 55
Query: 67 TEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAIL 126
CI A IL ++ V PC++F++F+C GWI NP+P+ + + L L
Sbjct: 56 KPECIEAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKL 115
Query: 127 KHLLENT-TFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIG-GWNIT----- 179
K LLE + + +EA QK + Y SC+ + IE+ A+PL ++ W +
Sbjct: 116 KELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIG 175
Query: 180 --GPWDQDNF--MEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYY 235
G W + F ++ L G Y + F +Y+S D K+SN +++++DQ+ L L R+ Y
Sbjct: 176 PEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDY 235
Query: 236 L-NRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEE 294
L N T + A +M + +LLG + M+ VL LEI++A I +P + R E
Sbjct: 236 LDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEA 295
Query: 295 KIYHKMSISELQALAPSMDWLEFLSFLLSPL------ELSDSEPVVVYGMDYLQQVSELI 348
+Y+KM+ISEL A+ P DWL ++ ++ ++S SE VVV Y + + ++
Sbjct: 296 -MYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRIL 354
Query: 349 NRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDA 408
+ NYL+W +V +L RRF+ + + GT + +P+W C++ + A
Sbjct: 355 GSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTT-TLLPQWDKCVNFIESA 413
Query: 409 LGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALG-QLVWMDEKTRQAAKEKADAIY 467
L + +G +FV F KE+ E ++ +R AF + L + WMD T++ AKEKA A+
Sbjct: 414 LPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVL 473
Query: 468 DMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMT 527
+G+P+FI+ +++ + SE +F N+L + A+ LRK + +W
Sbjct: 474 AKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTN 533
Query: 528 PQTVNAYYLPTKNEIVFPAGILQAPFY-ARNHPKALNFGGIGVVMGHELTHAFDDQGREY 586
P TVNA+Y + N+I FPAG LQ PF+ +P++L++G IGV++GHE TH FD+ GR+Y
Sbjct: 534 PTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKY 593
Query: 587 DKEGNLRPWWQNESLAAFRNHTACMEEQYNQY--QVNGERLNGRQTLGENIADNGGLKAA 644
DK GNL PWW ES F+ T CM QY+ Y + G + G++TLGENIADNGGL+ A
Sbjct: 594 DKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREA 653
Query: 645 YNAYKAWL--RKHG-EEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPA 701
+ AY+ W+ R+ G EE LP + TN+QLFF+ +A V C+ PE++ E + HSP
Sbjct: 654 FRAYRKWINDRRQGLEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPP 713
Query: 702 RFRVLGTLSNSRDFLRHFGCPVGSPMNPG-QLCEVW 736
+FRV G +SN +F + F CP S MN G C +W
Sbjct: 714 QFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCRLW 749
>gi|4557691 Kell blood group, metallo-endopeptidase [Homo sapiens]
Length = 732
Score = 359 bits (922), Expect = 4e-99
Identities = 224/718 (31%), Positives = 355/718 (49%), Gaps = 53/718 (7%)
Query: 39 LLLAALLLGCLVALGVQYH---RDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFS 95
+L A L+LG L+ V ++ C T C+ + L S + V+PC DF+ F+
Sbjct: 48 VLTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFA 107
Query: 96 CGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQV 155
CG N N+F L +N+ L+ +LE E+K +FY SC+
Sbjct: 108 CGRAKETN---------NSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDT 158
Query: 156 ERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSS 215
IE G PLR +IE++GGW I+G W NF L+ + Y PFF Y+ S
Sbjct: 159 LAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASP 218
Query: 216 NSNVIQVDQSGLFLPSRDYYLNRTANEK----VLTAYLDYMEELGMLLGGRPTSTREQMQ 271
++ VIQ+DQ P D L + +K + YL Y+ +LG LLGG P+ +E
Sbjct: 219 HTPVIQIDQ-----PEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSS 273
Query: 272 QVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSE 331
+ + +L P +QRR + K++ ++I +L+ +AP++DWL L +P+ LS S+
Sbjct: 274 LSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQ 333
Query: 332 PVVVYGMDYLQQVSELINR---TEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLY 388
+VV+ ++YL+ +S+L+ + L +++I LV + +LD +F+ A+ KL + L
Sbjct: 334 SLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLR 393
Query: 389 GTKKS----CVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEA 444
+ PRW C+ T L +LFV+ F ++ A + + IR A
Sbjct: 394 ELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITR 453
Query: 445 LGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLY 504
L L WM+E+T+ A++K + +G ++ L+P+ Y+ ++ SF Q++L+
Sbjct: 454 LRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLG-SSFLQSVLSCV 512
Query: 505 NFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNF 564
+ +P + +W ++P VNAYY + + +VFPAG+LQ PF+ +P+A+NF
Sbjct: 513 RSLRARIVQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNF 572
Query: 565 GGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHT-----ACMEEQYNQYQ 619
G G +M HEL H F L P A NH C++ Y +
Sbjct: 573 GAAGSIMAHELLHIFYQL---------LLP----GGCLACDNHALQEAHLCLKRHYAAFP 619
Query: 620 V-NGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQ 678
+ + N T EN AD GGL A AY L +H E LP++ L+ Q+FF +AQ
Sbjct: 620 LPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQ 679
Query: 679 VWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 736
V C +P+ SH D HSP RV G LS++ F R+F C G+ +NP C++W
Sbjct: 680 VMCRKPSPQDSH-----DTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 732
>gi|124487387 ring finger protein 207 [Homo sapiens]
Length = 634
Score = 32.7 bits (73), Expect = 1.2
Identities = 23/73 (31%), Positives = 38/73 (52%), Gaps = 3/73 (4%)
Query: 434 ISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIG-FPDFILEPKE--LDDVYDGYE 490
+ ++TA EA+ L M E+ R +A E+ DAI+ + G D + E K L V YE
Sbjct: 211 VKALQTATREAIALLQAMVEEVRHSAAEEEDAIHALFGSMQDRLAERKALLLQAVQSQYE 270
Query: 491 ISEDSFFQNMLNL 503
+ +F + + +L
Sbjct: 271 EKDKAFKEQLSHL 283
>gi|239753431 PREDICTED: similar to endothelin converting
enzyme-like 1 [Homo sapiens]
Length = 97
Score = 32.0 bits (71), Expect = 2.1
Identities = 19/66 (28%), Positives = 32/66 (48%), Gaps = 1/66 (1%)
Query: 353 PSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFA 412
P +L+NYL+W++V + L F KL + + G+ K + + + G A
Sbjct: 13 PRVLHNYLVWDVVVVLSEHLFLPFHEVLHKLAQEMEGSGK-LQELARVSLGQANHHYGMA 71
Query: 413 LGSLFV 418
L +LFV
Sbjct: 72 LRALFV 77
>gi|239747995 PREDICTED: hypothetical protein XP_002346505 [Homo
sapiens]
Length = 97
Score = 32.0 bits (71), Expect = 2.1
Identities = 19/66 (28%), Positives = 32/66 (48%), Gaps = 1/66 (1%)
Query: 353 PSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFA 412
P +L+NYL+W++V + L F KL + + G+ K + + + G A
Sbjct: 13 PRVLHNYLVWDVVVVLSEHLFLPFHEVLHKLAQEMEGSGK-LQELARVSLGQANHHYGMA 71
Query: 413 LGSLFV 418
L +LFV
Sbjct: 72 LRALFV 77
>gi|239741893 PREDICTED: hypothetical protein XP_002342317 [Homo
sapiens]
Length = 97
Score = 32.0 bits (71), Expect = 2.1
Identities = 19/66 (28%), Positives = 32/66 (48%), Gaps = 1/66 (1%)
Query: 353 PSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFA 412
P +L+NYL+W++V + L F KL + + G+ K + + + G A
Sbjct: 13 PRVLHNYLVWDVVVVLSEHLFLPFHEVLHKLAQEMEGSGK-LQELARVSLGQANHHYGMA 71
Query: 413 LGSLFV 418
L +LFV
Sbjct: 72 LRALFV 77
>gi|20544129 DEAH (Asp-Glu-Ala-His) box polypeptide 35 [Homo
sapiens]
Length = 703
Score = 31.2 bits (69), Expect = 3.6
Identities = 15/42 (35%), Positives = 23/42 (54%), Gaps = 1/42 (2%)
Query: 633 ENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFV 674
+++A+N G YN Y A L + Q+LP L NH L+ +
Sbjct: 27 QSLAENSGTTVVYNPYAA-LSIEQQRQKLPVFKLRNHILYLI 67
>gi|83641876 serine carboxypeptidase vitellogenic-like [Homo
sapiens]
Length = 476
Score = 30.0 bits (66), Expect = 8.0
Identities = 20/69 (28%), Positives = 36/69 (52%), Gaps = 3/69 (4%)
Query: 441 FEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNM 500
+ E L Q+ +DEK ++ +++ + I ++ + LD + DG S+ S+FQN+
Sbjct: 249 YAEFLYQIGLLDEKQKKYFQKQCHECIEHIRKQNWFEAFEILDKLLDGDLTSDPSYFQNV 308
Query: 501 L---NLYNF 506
N YNF
Sbjct: 309 TGCSNYYNF 317
>gi|83641874 serine carboxypeptidase vitellogenic-like [Homo
sapiens]
Length = 476
Score = 30.0 bits (66), Expect = 8.0
Identities = 20/69 (28%), Positives = 36/69 (52%), Gaps = 3/69 (4%)
Query: 441 FEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNM 500
+ E L Q+ +DEK ++ +++ + I ++ + LD + DG S+ S+FQN+
Sbjct: 249 YAEFLYQIGLLDEKQKKYFQKQCHECIEHIRKQNWFEAFEILDKLLDGDLTSDPSYFQNV 308
Query: 501 L---NLYNF 506
N YNF
Sbjct: 309 TGCSNYYNF 317
>gi|148234215 guanylate binding protein 4-like [Homo sapiens]
Length = 638
Score = 30.0 bits (66), Expect = 8.0
Identities = 24/74 (32%), Positives = 38/74 (51%), Gaps = 9/74 (12%)
Query: 439 TAFEEALGQLVWMDEKT---RQAAKEKADAIYD----MIGFPDFILEPKE--LDDVYDGY 489
T +AL QL ++ E T R + + D + D + FPDFI ++ L+ DG+
Sbjct: 133 TINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGH 192
Query: 490 EISEDSFFQNMLNL 503
I+ED + +N L L
Sbjct: 193 PITEDEYLENALKL 206
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,032,411
Number of Sequences: 37866
Number of extensions: 1269051
Number of successful extensions: 3034
Number of sequences better than 10.0: 24
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 2943
Number of HSP's gapped (non-prelim): 27
length of query: 736
length of database: 18,247,518
effective HSP length: 110
effective length of query: 626
effective length of database: 14,082,258
effective search space: 8815493508
effective search space used: 8815493508
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.