BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|7662254 hephaestin isoform b [Homo sapiens] (891 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|7662254 hephaestin isoform b [Homo sapiens] 1852 0.0 gi|195963313 hephaestin isoform a [Homo sapiens] 1852 0.0 gi|195947365 hephaestin isoform c [Homo sapiens] 1846 0.0 gi|148886707 hephaestin-like 1 [Homo sapiens] 894 0.0 gi|4557485 ceruloplasmin precursor [Homo sapiens] 830 0.0 gi|4503647 coagulation factor VIII isoform a precursor [Homo sap... 387 e-107 gi|105990535 coagulation factor V precursor [Homo sapiens] 367 e-101 gi|22212918 ciliary neurotrophic factor receptor preproprotein [... 32 2.0 gi|4502931 ciliary neurotrophic factor receptor preproprotein [H... 32 2.0 gi|73760405 thymopoietin isoform beta [Homo sapiens] 32 2.6 gi|169203189 PREDICTED: hypothetical protein LOC338667 [Homo sap... 32 3.4 gi|169203683 PREDICTED: hypothetical protein LOC338667 [Homo sap... 31 5.9 gi|169202109 PREDICTED: hypothetical protein LOC338667 [Homo sap... 31 5.9 gi|4505941 DNA directed RNA polymerase II polypeptide B [Homo sa... 30 7.6 gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens] 30 7.6 gi|148613866 tudor domain containing 10 isoform a [Homo sapiens] 30 7.6 gi|148613864 tudor domain containing 10 isoform b [Homo sapiens] 30 7.6 gi|62420886 discoidin domain receptor family, member 2 precursor... 30 10.0 gi|62420884 discoidin domain receptor family, member 2 precursor... 30 10.0 >gi|7662254 hephaestin isoform b [Homo sapiens] Length = 891 Score = 1852 bits (4798), Expect = 0.0 Identities = 891/891 (100%), Positives = 891/891 (100%) Query: 1 MHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFP 60 MHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFP Sbjct: 1 MHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFP 60 Query: 61 ATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAH 120 ATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAH Sbjct: 61 ATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAH 120 Query: 121 EIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHL 180 EIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHL Sbjct: 121 EIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHL 180 Query: 181 EEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGL 240 EEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGL Sbjct: 181 EEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGL 240 Query: 241 VAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGA 300 VAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGA Sbjct: 241 VAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGA 300 Query: 301 DGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFL 360 DGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFL Sbjct: 301 DGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFL 360 Query: 361 FSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIM 420 FSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIM Sbjct: 361 FSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIM 420 Query: 421 QPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYC 480 QPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYC Sbjct: 421 QPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYC 480 Query: 481 PDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHL 540 PDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHL Sbjct: 481 PDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHL 540 Query: 541 GILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAEPGEVVTYQWNIPER 600 GILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAEPGEVVTYQWNIPER Sbjct: 541 GILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAEPGEVVTYQWNIPER 600 Query: 601 SGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLI 660 SGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLI Sbjct: 601 SGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLI 660 Query: 661 FDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVA 720 FDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVA Sbjct: 661 FDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVA 720 Query: 721 WYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCH 780 WYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCH Sbjct: 721 WYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCH 780 Query: 781 VTDHVHAGMETLFTVFSRTEHLSPLTVITKETEKAVPPRDIEEGNVKMLGMQIPIKNVEM 840 VTDHVHAGMETLFTVFSRTEHLSPLTVITKETEKAVPPRDIEEGNVKMLGMQIPIKNVEM Sbjct: 781 VTDHVHAGMETLFTVFSRTEHLSPLTVITKETEKAVPPRDIEEGNVKMLGMQIPIKNVEM 840 Query: 841 LASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ 891 LASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ Sbjct: 841 LASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ 891 >gi|195963313 hephaestin isoform a [Homo sapiens] Length = 1161 Score = 1852 bits (4798), Expect = 0.0 Identities = 891/891 (100%), Positives = 891/891 (100%) Query: 1 MHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFP 60 MHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFP Sbjct: 271 MHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFP 330 Query: 61 ATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAH 120 ATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAH Sbjct: 331 ATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAH 390 Query: 121 EIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHL 180 EIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHL Sbjct: 391 EIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHL 450 Query: 181 EEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGL 240 EEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGL Sbjct: 451 EEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGL 510 Query: 241 VAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGA 300 VAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGA Sbjct: 511 VAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGA 570 Query: 301 DGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFL 360 DGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFL Sbjct: 571 DGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFL 630 Query: 361 FSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIM 420 FSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIM Sbjct: 631 FSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIM 690 Query: 421 QPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYC 480 QPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYC Sbjct: 691 QPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYC 750 Query: 481 PDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHL 540 PDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHL Sbjct: 751 PDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHL 810 Query: 541 GILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAEPGEVVTYQWNIPER 600 GILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAEPGEVVTYQWNIPER Sbjct: 811 GILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAEPGEVVTYQWNIPER 870 Query: 601 SGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLI 660 SGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLI Sbjct: 871 SGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLI 930 Query: 661 FDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVA 720 FDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVA Sbjct: 931 FDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVA 990 Query: 721 WYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCH 780 WYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCH Sbjct: 991 WYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCH 1050 Query: 781 VTDHVHAGMETLFTVFSRTEHLSPLTVITKETEKAVPPRDIEEGNVKMLGMQIPIKNVEM 840 VTDHVHAGMETLFTVFSRTEHLSPLTVITKETEKAVPPRDIEEGNVKMLGMQIPIKNVEM Sbjct: 1051 VTDHVHAGMETLFTVFSRTEHLSPLTVITKETEKAVPPRDIEEGNVKMLGMQIPIKNVEM 1110 Query: 841 LASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ 891 LASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ Sbjct: 1111 LASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ 1161 Score = 529 bits (1362), Expect = e-150 Identities = 287/706 (40%), Positives = 401/706 (56%), Gaps = 27/706 (3%) Query: 107 LLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRY 166 L G R Y++ ++QW+Y P G + T + L + ++ F + +RIGGTY K Y Sbjct: 23 LTDGATRVYYLGIRDVQWNYAPKGRNVITNQPL-DSDIVASSFLKSDKNRIGGTYKKTIY 81 Query: 167 EAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDY 226 + ++D+++ +++ + LG LGPV++AEVGD I + N A++P+++ PHGVFYEKD Sbjct: 82 KEYKDDSYTDEV--AQPAWLGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDS 139 Query: 227 EGTVYNDGSSYPGLV---AKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTN 283 EG++Y DGSS P P Y WT+P PT DPACLTW+Y S D RD Sbjct: 140 EGSLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIA 199 Query: 284 SGLVGPLLVCRAGALGADG--KQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLS 341 +GL+GPL+ C+ GAL + +++ VD +FFLLF+V+DEN SW+ N N A D + Sbjct: 200 TGLIGPLITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVD 259 Query: 342 EDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQ 401 ++ E FQ+SNRMHAINGF+F NLP L+MC VAWHL G+G E DVH F G + + Sbjct: 260 KEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTR 319 Query: 402 GMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQR 461 G A +FP TFV A M P GT+ I CQ SH GM+A+Y V C A P Sbjct: 320 GHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSC--SMAPPVDL 377 Query: 462 YQA-ARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFR 520 R Y+I A E++WDY P N E S F +G Y K + Sbjct: 378 LTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYE 437 Query: 521 EYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVL----- 575 + D TF+ + + HLGILGP+I+ EVGD + VVF N AS+P+S+ HGV Sbjct: 438 AFQDETFQ-EKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDY 496 Query: 576 ------ESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGL 629 + ++ L A+P E VTY+W +P +GP D AC++W+Y+SA DPI+D SGL Sbjct: 497 EGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGL 556 Query: 630 VGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDE 689 VGPL +C+ G L G + +D+EF LLF + DENKSWY N A D ++ E Sbjct: 557 VGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAA-AMLDFRLLSEDIE 615 Query: 690 TFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGEN 749 F +SN+MHAING L++NL L M +G+ VAW++L +G + D+H + F + + Sbjct: 616 GFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQL---QG 672 Query: 750 YRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTV 795 R LFP TF + M N GT+ ++C H AGM ++ V Sbjct: 673 MRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNV 718 >gi|195947365 hephaestin isoform c [Homo sapiens] Length = 1160 Score = 1846 bits (4782), Expect = 0.0 Identities = 890/891 (99%), Positives = 890/891 (99%), Gaps = 1/891 (0%) Query: 1 MHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFP 60 MHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFP Sbjct: 271 MHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFP 330 Query: 61 ATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAH 120 ATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAH Sbjct: 331 ATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAH 390 Query: 121 EIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHL 180 EIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHL Sbjct: 391 EIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHL 450 Query: 181 EEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGL 240 EEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGL Sbjct: 451 EEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGL 510 Query: 241 VAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGA 300 VAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGA Sbjct: 511 VAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGA 570 Query: 301 DGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFL 360 DGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFL Sbjct: 571 DGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFL 630 Query: 361 FSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIM 420 FSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIM Sbjct: 631 FSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIM 690 Query: 421 QPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYC 480 QPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYC Sbjct: 691 QPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYC 750 Query: 481 PDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHL 540 PDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHL Sbjct: 751 PDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHL 810 Query: 541 GILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAEPGEVVTYQWNIPER 600 GILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAEPGEVVTYQWNIPER Sbjct: 811 GILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAEPGEVVTYQWNIPER 870 Query: 601 SGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLI 660 SGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLI Sbjct: 871 SGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLI 930 Query: 661 FDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVA 720 FDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVA Sbjct: 931 FDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVA 990 Query: 721 WYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCH 780 WYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCH Sbjct: 991 WYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCH 1050 Query: 781 VTDHVHAGMETLFTVFSRTEHLSPLTVITKETEKAVPPRDIEEGNVKMLGMQIPIKNVEM 840 VTDHVHAGMETLFTVFSRTEHLSPLTVITKETEK VPPRDIEEGNVKMLGMQIPIKNVEM Sbjct: 1051 VTDHVHAGMETLFTVFSRTEHLSPLTVITKETEK-VPPRDIEEGNVKMLGMQIPIKNVEM 1109 Query: 841 LASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ 891 LASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ Sbjct: 1110 LASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ 1160 Score = 529 bits (1362), Expect = e-150 Identities = 287/706 (40%), Positives = 401/706 (56%), Gaps = 27/706 (3%) Query: 107 LLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRY 166 L G R Y++ ++QW+Y P G + T + L + ++ F + +RIGGTY K Y Sbjct: 23 LTDGATRVYYLGIRDVQWNYAPKGRNVITNQPL-DSDIVASSFLKSDKNRIGGTYKKTIY 81 Query: 167 EAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDY 226 + ++D+++ +++ + LG LGPV++AEVGD I + N A++P+++ PHGVFYEKD Sbjct: 82 KEYKDDSYTDEV--AQPAWLGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDS 139 Query: 227 EGTVYNDGSSYPGLV---AKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTN 283 EG++Y DGSS P P Y WT+P PT DPACLTW+Y S D RD Sbjct: 140 EGSLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIA 199 Query: 284 SGLVGPLLVCRAGALGADG--KQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLS 341 +GL+GPL+ C+ GAL + +++ VD +FFLLF+V+DEN SW+ N N A D + Sbjct: 200 TGLIGPLITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVD 259 Query: 342 EDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQ 401 ++ E FQ+SNRMHAINGF+F NLP L+MC VAWHL G+G E DVH F G + + Sbjct: 260 KEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTR 319 Query: 402 GMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQR 461 G A +FP TFV A M P GT+ I CQ SH GM+A+Y V C A P Sbjct: 320 GHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSC--SMAPPVDL 377 Query: 462 YQA-ARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFR 520 R Y+I A E++WDY P N E S F +G Y K + Sbjct: 378 LTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYE 437 Query: 521 EYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVL----- 575 + D TF+ + + HLGILGP+I+ EVGD + VVF N AS+P+S+ HGV Sbjct: 438 AFQDETFQ-EKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDY 496 Query: 576 ------ESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGL 629 + ++ L A+P E VTY+W +P +GP D AC++W+Y+SA DPI+D SGL Sbjct: 497 EGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGL 556 Query: 630 VGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDE 689 VGPL +C+ G L G + +D+EF LLF + DENKSWY N A D ++ E Sbjct: 557 VGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAA-AMLDFRLLSEDIE 615 Query: 690 TFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGEN 749 F +SN+MHAING L++NL L M +G+ VAW++L +G + D+H + F + + Sbjct: 616 GFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQL---QG 672 Query: 750 YRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTV 795 R LFP TF + M N GT+ ++C H AGM ++ V Sbjct: 673 MRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNV 718 >gi|148886707 hephaestin-like 1 [Homo sapiens] Length = 1159 Score = 894 bits (2311), Expect = 0.0 Identities = 432/869 (49%), Positives = 580/869 (66%), Gaps = 13/869 (1%) Query: 1 MHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFP 60 MHA+NG++FGN PE +MC + V+WHLFGMGNEID+H+ +F+G +RGH TDV N+FP Sbjct: 268 MHALNGYLFGNFPEPDMCVGESVSWHLFGMGNEIDIHSIYFYGNTFISRGHRTDVVNLFP 327 Query: 61 ATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAH 120 ATF+T EM+ PG W+I+CQV+ H + GM Y V +C + G+ R+YFI A Sbjct: 328 ATFLTTEMIAENPGKWMITCQVSDHLQAGMLGQYNVDNCKSDIFYPKMKGQQRRYFIAAE 387 Query: 121 EIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHL 180 +I WDY P G++ +G L GS SD +F + +RIGG YWKVRY F D TF ++ L Sbjct: 388 KILWDYAPQGYNKFSGLPLNASGSDSDLYFTQGDNRIGGKYWKVRYTEFVDATFTKRKRL 447 Query: 181 E-EDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPG 239 E+ HLGILGPVI+AEVGDT+ V F N+A + +S+ PHGV Y+K + DG PG Sbjct: 448 SAEEAHLGILGPVIKAEVGDTLLVTFANKADKVYSILPHGVIYDKASDAAPNLDGFVKPG 507 Query: 240 LVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALG 299 KP E TY+WTVP PTA DP CLT++YFSA DPI+DT+SGLVGPLLVC+ G L Sbjct: 508 AHVKPGETFTYKWTVPESVSPTAGDPPCLTYLYFSAVDPIKDTSSGLVGPLLVCKKGVLN 567 Query: 300 ADGKQKGVDKEFFLLFTVLDENKSWYSNAN-QAAAMLDFRLLSEDIEGFQDSNRMHAING 358 ADG QKG+DKEF+LLFTV DEN S Y + N Q F + ED E F SNRMHA+NG Sbjct: 568 ADGTQKGIDKEFYLLFTVFDENLSRYFDENIQKFIWHPFSIDKEDKE-FVKSNRMHAVNG 626 Query: 359 FLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMA 418 +++ N P L+MCK D V+WHL+GLGT+TD+HG++FQGNT+ L+G + + LFPH A Sbjct: 627 YMYGNQPGLNMCKRDRVSWHLIGLGTDTDMHGIVFQGNTIHLRGTHRDSLALFPHMATTA 686 Query: 419 IMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWD 478 MQPD+ G F ++C H GM IY VS C + QRY R +YI AEEVEWD Sbjct: 687 FMQPDHAGIFRVFCATMPHLSRGMGQIYEVSSCDNRDPS-EQRYGMIRTFYIAAEEVEWD 745 Query: 479 YCPDRSWERE-WHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPE 537 Y P+++WE E H + + +G IF++ + +GS+YKK V+REYTDG F + R E Sbjct: 746 YAPNKNWEFEKQHVDARGERHGDIFMNRTENWIGSQYKKVVYREYTDGEFVEIKARPPRE 805 Query: 538 EHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPL---AAEPGEVVTYQ 594 EHL +LGP+I EVG+ + ++FKN ASRPYS+ A GV E + +PGEV TY+ Sbjct: 806 EHLELLGPMIHAEVGNTVLIIFKNKASRPYSISAQGVEEMDSGKQFQVPMTKPGEVKTYR 865 Query: 595 WNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDMDREF 654 WNIP+RSGPGP+D C+ W+YYS V+ +KD YSGL+GPL C+KG+L G RSD+D EF Sbjct: 866 WNIPKRSGPGPSDPNCIPWVYYSTVNFVKDTYSGLMGPLITCRKGVLNEKGRRSDVDYEF 925 Query: 655 ALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMY 714 ALLFL+F+EN+SWYL++N+ + ++DP D+ F ESN+MHAINGK++ NL GL M Sbjct: 926 ALLFLVFNENESWYLDDNIKKYLNKDPRDFKRTDD-FEESNRMHAINGKIFGNLHGLIMN 984 Query: 715 QGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGT 774 + WY+L +G +VD+HTIH+HAESFL++ ++YR DV DLFPGTF+ +E+ A +PGT Sbjct: 985 EDTMTNWYLLGIGSEVDIHTIHYHAESFLFKIDKSYREDVYDLFPGTFQTIELFADHPGT 1044 Query: 775 WLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITK--ETEKAVPPRDIEEGNVKM--LG 830 WL+HCHV+DH+HAGMET +TV ++ P + + + A P + G ++ G Sbjct: 1045 WLLHCHVSDHIHAGMETTYTVLRNIDNRIPYSTTSPGVASHPATVPSNERPGKEQLYFFG 1104 Query: 831 MQIPIKNVEMLASVLVAISVTLLLVVLAL 859 + + +L I + LL+ + L Sbjct: 1105 KNLGPTGAKAALVILFIIGLLLLITTVIL 1133 Score = 511 bits (1317), Expect = e-145 Identities = 281/706 (39%), Positives = 393/706 (55%), Gaps = 24/706 (3%) Query: 108 LTGKV-RQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRY 166 L G V R Y+I E W+Y P G + TGK+ E ++ F ++ +RIG Y K Y Sbjct: 21 LVGTVTRTYYIGIVEEYWNYVPQGKNVITGKSFTED-KLATLFLERGPNRIGSIYKKAVY 79 Query: 167 EAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDY 226 F D T+ + + + LG LGP++RAEVGD I + N AS+P+S+ PHGVFY KD Sbjct: 80 RRFTDGTYS--IEIPKPPWLGFLGPILRAEVGDVIVIHLKNFASRPYSLHPHGVFYNKDS 137 Query: 227 EGTVYNDGSSYPGL---VAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTN 283 EG +Y DG+S + P + TY W V PT D CLTW+Y S D +D Sbjct: 138 EGALYPDGTSGRNKNDDMVPPGKNYTYVWPVREEYAPTPADANCLTWVYHSHIDAPKDIC 197 Query: 284 SGLVGPLLVCRAGALGA-DGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSE 342 SGL+GPLLVC+ G L G + VD+EF ++FT++DEN+SWY N N + + + Sbjct: 198 SGLIGPLLVCKEGILNRYSGTRNDVDREFVIMFTLVDENQSWYLNENIKHFCTNPDSVDK 257 Query: 343 DIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQG 402 FQ SN+MHA+NG+LF N P DMC G++V+WHL G+G E D+H + F GNT +G Sbjct: 258 KDAVFQRSNKMHALNGYLFGNFPEPDMCVGESVSWHLFGMGNEIDIHSIYFYGNTFISRG 317 Query: 403 MRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRY 462 R LFP TF+ M +N G + I CQ H +AGM YNV C P+ + Sbjct: 318 HRTDVVNLFPATFLTTEMIAENPGKWMITCQVSDHLQAGMLGQYNVDNCKSDIFYPKMKG 377 Query: 463 QAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREY 522 Q R Y+I AE++ WDY P + + S ++ + D +G +Y K + E+ Sbjct: 378 QQRR-YFIAAEKILWDYAPQGYNKFSGLPLNASGSDSDLYFTQGDNRIGGKYWKVRYTEF 436 Query: 523 TDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTT--- 579 D TF + + E HLGILGP+IK EVGD L V F N A + YS+ HGV+ Sbjct: 437 VDATFTKRKRLSAEEAHLGILGPVIKAEVGDTLLVTFANKADKVYSILPHGVIYDKASDA 496 Query: 580 -------VWPLA-AEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVG 631 V P A +PGE TY+W +PE P D C++++Y+SAVDPIKD SGLVG Sbjct: 497 APNLDGFVKPGAHVKPGETFTYKWTVPESVSPTAGDPPCLTYLYFSAVDPIKDTSSGLVG 556 Query: 632 PLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETF 691 PL +C+KG+L G + +D+EF LLF +FDEN S Y +EN+ P SI+ +D+ F Sbjct: 557 PLLVCKKGVLNADGTQKGIDKEFYLLFTVFDENLSRYFDENIQKF-IWHPFSIDKEDKEF 615 Query: 692 LESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYR 751 ++SN+MHA+NG +Y N GL M + +RV+W+++ +G D D+H I F + R Sbjct: 616 VKSNRMHAVNGYMYGNQPGLNMCKRDRVSWHLIGLGTDTDMHGIVFQGNTIHLRGTHR-- 673 Query: 752 ADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFS 797 D + LFP M + G + + C H+ GM ++ V S Sbjct: 674 -DSLALFPHMATTAFMQPDHAGIFRVFCATMPHLSRGMGQIYEVSS 718 >gi|4557485 ceruloplasmin precursor [Homo sapiens] Length = 1065 Score = 830 bits (2145), Expect = 0.0 Identities = 403/810 (49%), Positives = 537/810 (66%), Gaps = 17/810 (2%) Query: 1 MHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFP 60 M+++NG+ FG+LP L+MCA+ RV W+LFGMGNE+DVH AFFHGQ LT + + D N+FP Sbjct: 259 MYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFP 318 Query: 61 ATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGK-VRQYFIEA 119 AT A MV PG W++SCQ +H + G+QA ++V+ C+ + D + GK VR Y+I A Sbjct: 319 ATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGKHVRHYYIAA 378 Query: 120 HEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETF-QEKM 178 EI W+Y P G D T +NL PGS S FF++ ++RIGG+Y K+ Y + D +F K Sbjct: 379 EEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNRKE 438 Query: 179 HLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYN-----D 233 E+ HLGILGPVI AEVGDTI+V F+N+ + P S++P GV + K+ EGT Y+ Sbjct: 439 RGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQ 498 Query: 234 GSSYPGLVAK--PFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLL 291 S P + P E TY WTVP GPT DP CL MY+SA DP +D +GL+GP+ Sbjct: 499 SRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFTGLIGPMK 558 Query: 292 VCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSN 351 +C+ G+L A+G+QK VDKEF+L TV DEN+S N + ++ E FQ+SN Sbjct: 559 ICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQESN 618 Query: 352 RMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLF 411 +MH++NGF++ N P L MCKGD+V W+L G E DVHG+ F GNT +G R+ A LF Sbjct: 619 KMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTANLF 678 Query: 412 PHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIM 471 P T + M PD GTF + C H GM+ Y V+QC Q+ Y R YYI Sbjct: 679 PQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCR-RQSEDSTFYLGERTYYIA 737 Query: 472 AEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPR 531 A EVEWDY P R WE+E H+ E++ FL + +GS+YKK V+R+YTD TFR+P Sbjct: 738 AVEVEWDYSPQREWEKELHHLQEQN-VSNAFLDKGEFYIGSKYKKVVYRQYTDSTFRVPV 796 Query: 532 PRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGV-LESTTVWPLAAEPGEV 590 R EEHLGILGP + +VGD + ++FKN A+RPYS+HAHGV ES+TV P PGE Sbjct: 797 ERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTESSTVTPTL--PGET 854 Query: 591 VTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDM 650 +TY W IPERSG G DSAC+ W YYS VD +KD+YSGL+GPL +C++ L+ R + Sbjct: 855 LTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFNPRRKL 914 Query: 651 DREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRG 710 EFALLFL+FDEN+SWYL++N+ T+ S P +N DE F+ESNKMHAING+++ NL+G Sbjct: 915 --EFALLFLVFDENESWYLDDNIKTY-SDHPEKVNKDDEEFIESNKMHAINGRMFGNLQG 971 Query: 711 LTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVAS 770 LTM+ G+ V WY++ MG ++DLHT+HFH SF Y++ Y +DV D+FPGT++ +EM Sbjct: 972 LTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPR 1031 Query: 771 NPGTWLMHCHVTDHVHAGMETLFTVFSRTE 800 PG WL+HCHVTDH+HAGMET +TV + Sbjct: 1032 TPGIWLLHCHVTDHIHAGMETTYTVLQNED 1061 Score = 476 bits (1225), Expect = e-134 Identities = 267/712 (37%), Positives = 386/712 (54%), Gaps = 43/712 (6%) Query: 111 KVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQ 170 K + Y+I E WDY D K + S+ + Q RIG Y K Y + Sbjct: 20 KEKHYYIGIIETTWDYAS---DHGEKKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYT 76 Query: 171 DETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTV 230 DETF+ +E+ LG LGP+I+AE GD + V N AS+P++ HG+ Y K++EG + Sbjct: 77 DETFRTT--IEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAI 134 Query: 231 YNDGSS---------YPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRD 281 Y D ++ YPG E+ TY P D C+T +Y S D +D Sbjct: 135 YPDNTTDFQRADDKVYPG------EQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKD 188 Query: 282 TNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLS 341 SGL+GPL++C+ +L + K+K +D+EF ++F+V+DEN SWY N + + Sbjct: 189 IASGLIGPLIICKKDSLDKE-KEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVD 247 Query: 342 EDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQ 401 +D E FQ+SNRM+++NG+ F +LP L MC D V W+L G+G E DVH F G + + Sbjct: 248 KDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNK 307 Query: 402 GMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQR 461 R LFP T A M N G + + CQ +H +AG++A + V +C + R Sbjct: 308 NYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIR 367 Query: 462 YQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFRE 521 + R YYI AEE+ W+Y P N + S +F +G YKK V+RE Sbjct: 368 GKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYRE 427 Query: 522 YTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVL------ 575 YTD +F + R EEHLGILGP+I EVGD + V F N + P S+ GV Sbjct: 428 YTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNE 487 Query: 576 ----------ESTTVWPLAAE--PGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIK 623 +S +V P A+ P E TY+W +P+ GP D C++ +YYSAVDP K Sbjct: 488 GTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTK 547 Query: 624 DMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGS 683 D+++GL+GP+ IC+KG L +G + D+D+EF L +FDEN+S LE+N+ + P Sbjct: 548 DIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMF-TTAPDQ 606 Query: 684 INLQDETFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFL 743 ++ +DE F ESNKMH++NG +Y N GLTM +G+ V WY+ + G + D+H I+F ++L Sbjct: 607 VDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYL 666 Query: 744 YRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTV 795 +R GE R D +LFP T + M GT+ + C TDH GM+ +TV Sbjct: 667 WR-GE--RRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTV 715 >gi|4503647 coagulation factor VIII isoform a precursor [Homo sapiens] Length = 2351 Score = 387 bits (994), Expect = e-107 Identities = 250/751 (33%), Positives = 366/751 (48%), Gaps = 109/751 (14%) Query: 113 RQYFIEAHEIQWDYGPMGHD-GSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQD 171 R+Y++ A E+ WDY M D G + R P + F +S Y K + F D Sbjct: 22 RRYYLGAVELSWDY--MQSDLGELPVDARFPPRVPKSFPFNTSV----VYKKTLFVEFTD 75 Query: 172 ETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVY 231 F + +G+LGP I+AEV DT+ + N AS P S+ GV Y K EG Y Sbjct: 76 HLFN--IAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEY 133 Query: 232 NDGSSYPGLVAKPFEKV------TYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSG 285 +D +S K +KV TY W V GP A DP CLT+ Y S D ++D NSG Sbjct: 134 DDQTSQR---EKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSG 190 Query: 286 LVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIE 345 L+G LLVCR G+L + Q +F LLF V DE KSW+S + + D Sbjct: 191 LIGALLVCREGSLAKEKTQ--TLHKFILLFAVFDEGKSWHSETKNSL------MQDRDAA 242 Query: 346 GFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRK 405 + +MH +NG++ +LP L C +V WH++G+GT +VH + +G+T ++ R+ Sbjct: 243 SARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQ 302 Query: 406 GAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAA 465 + + P TF+ A +LG F ++C SH+ GM A V CP + + A Sbjct: 303 ASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNEEA 362 Query: 466 R--------------------------------------IYYIMAEEVEWDYCP------ 481 ++YI AEE +WDY P Sbjct: 363 EDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVLAPD 422 Query: 482 DRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHLG 541 DRS++ + +L+N +G +YKK F YTD TF + R + G Sbjct: 423 DRSYKSQ-------------YLNNGPQRIGRKYKKVRFMAYTDETF---KTREAIQHESG 466 Query: 542 ILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAE--------------- 586 ILGPL+ GEVGD L ++FKN ASRPY+++ HG+ T V PL + Sbjct: 467 ILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGI---TDVRPLYSRRLPKGVKHLKDFPIL 523 Query: 587 PGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGG 646 PGE+ Y+W + GP +D C++ Y S V+ +D+ SGL+GPL IC K ++ G Sbjct: 524 PGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGN 583 Query: 647 RSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYA 706 + D+ +LF +FDEN+SWYL EN+ +P + L+D F SN MH+ING ++ Sbjct: 584 QIMSDKRNVILFSVFDENRSWYLTENIQRF-LPNPAGVQLEDPEFQASNIMHSINGYVFD 642 Query: 707 NLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVE 766 +L+ L++ E WY+L++G D ++ F +F ++ D + LFP + E V Sbjct: 643 SLQ-LSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKHK---MVYEDTLTLFPFSGETVF 698 Query: 767 MVASNPGTWLMHCHVTDHVHAGMETLFTVFS 797 M NPG W++ CH +D + GM L V S Sbjct: 699 MSMENPGLWILGCHNSDFRNRGMTALLKVSS 729 Score = 263 bits (673), Expect = 4e-70 Identities = 161/491 (32%), Positives = 237/491 (48%), Gaps = 50/491 (10%) Query: 1 MHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFP 60 MH +NG+V +LP L C +K V WH+ GMG +VH+ F G R H I P Sbjct: 250 MHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISP 309 Query: 61 ATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPV------------DLL 108 TF+TA+ + + G +L+ C ++SH DGM+A KV SC P + D L Sbjct: 310 ITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNEEAEDYDDDL 369 Query: 109 TG---------------------------KVRQYFIEAHEIQWDYGPMGHDGSTGKNLRE 141 T K ++I A E WDY P+ + Sbjct: 370 TDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPL-------VLAPD 422 Query: 142 PGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTI 201 S ++ RIG Y KVR+ A+ DETF+ + ++ + GILGP++ EVGDT+ Sbjct: 423 DRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHES--GILGPLLYGEVGDTL 480 Query: 202 QVVFYNRASQPFSMQPHGVFYEKD-YEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGP 260 ++F N+AS+P+++ PHG+ + Y + P E Y+WTV GP Sbjct: 481 LIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGP 540 Query: 261 TAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDE 320 T DP CLT Y S + RD SGL+GPLL+C ++ G Q DK +LF+V DE Sbjct: 541 TKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDE 600 Query: 321 NKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLL 380 N+SWY N + + + + FQ SN MH+ING++F +L +L +C + W++L Sbjct: 601 NRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSL-QLSVCLHEVAYWYIL 659 Query: 381 GLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREA 440 +G +TD V F G T + + + + LFP + M +N G + + C R Sbjct: 660 SIGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNR 719 Query: 441 GMRAIYNVSQC 451 GM A+ VS C Sbjct: 720 GMTALLKVSSC 730 Score = 254 bits (650), Expect = 2e-67 Identities = 137/347 (39%), Positives = 193/347 (55%), Gaps = 21/347 (6%) Query: 457 TPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKK 516 +PR + R Y+I A E WDY S N+++ S ++KK Sbjct: 1706 SPRSFQKKTRHYFIAAVERLWDYGMSSS-PHVLRNRAQSGSV-------------PQFKK 1751 Query: 517 AVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLE 576 VF+E+TDG+F P R EHLG+LGP I+ EV D + V F+N ASRPYS ++ + Sbjct: 1752 VVFQEFTDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISY 1811 Query: 577 STTVWPLA------AEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLV 630 A +P E TY W + P ++ C +W Y+S VD KD++SGL+ Sbjct: 1812 EEDQRQGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLI 1871 Query: 631 GPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDET 690 GPL +C L P GR +EFAL F IFDE KSWY EN+ + + P +I ++D T Sbjct: 1872 GPLLVCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERN-CRAPCNIQMEDPT 1930 Query: 691 FLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENY 750 F E+ + HAING + L GL M Q +R+ WY+L+MG + ++H+IHF F R E Y Sbjct: 1931 FKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEY 1990 Query: 751 RADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFS 797 + + +L+PG FE VEM+ S G W + C + +H+HAGM TLF V+S Sbjct: 1991 KMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYS 2037 Score = 195 bits (496), Expect = 1e-49 Identities = 123/343 (35%), Positives = 171/343 (49%), Gaps = 25/343 (7%) Query: 111 KVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQ 170 K R YFI A E WDYG M +N + GS+ + KV ++ F Sbjct: 1713 KTRHYFIAAVERLWDYG-MSSSPHVLRNRAQSGSVPQ-------------FKKVVFQEFT 1758 Query: 171 DETFQEKMHLEE-DRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGT 229 D +F + ++ E + HLG+LGP IRAEV D I V F N+AS+P+S + YE+D Sbjct: 1759 DGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEEDQR-- 1816 Query: 230 VYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGP 289 G+ KP E TY W V H PT + C W YFS D +D +SGL+GP Sbjct: 1817 ---QGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGP 1873 Query: 290 LLVCRAGALG-ADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQ 348 LLVC L A G+Q V +EF L FT+ DE KSWY N + + F+ Sbjct: 1874 LLVCHTNTLNPAHGRQVTV-QEFALFFTIFDETKSWYFTENMERNCRAPCNIQMEDPTFK 1932 Query: 349 DSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGN--TVQLQGMRKG 406 ++ R HAING++ LP L M + + W+LL +G+ ++H + F G+ TV+ + K Sbjct: 1933 ENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKM 1992 Query: 407 AAM-LFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNV 448 A L+P F M P G + + C G H AGM ++ V Sbjct: 1993 ALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLV 2035 Score = 166 bits (421), Expect = 7e-41 Identities = 114/357 (31%), Positives = 172/357 (48%), Gaps = 42/357 (11%) Query: 462 YQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFRE 521 + A R YY+ A E+ WDY E + F N + YKK +F E Sbjct: 18 FSATRRYYLGAVELSWDYMQSDLGELPVDARFPP-RVPKSFPFNTSVV----YKKTLFVE 72 Query: 522 YTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVW 581 +TD F I +PR +G+LGP I+ EV D + + KN AS P S+HA GV + W Sbjct: 73 FTDHLFNIAKPRP---PWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGV----SYW 125 Query: 582 PLA--AE----------------PGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIK 623 + AE PG TY W + + +GP +D C+++ Y S VD +K Sbjct: 126 KASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVK 185 Query: 624 DMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGS 683 D+ SGL+G L +C++G L ++ +F LLF +FDE KSW+ E + +D S Sbjct: 186 DLNSGLIGALLVCREGSLAKE--KTQTLHKFILLFAVFDEGKSWHSETKNSLMQDRDAAS 243 Query: 684 INLQDETFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFL 743 KMH +NG + +L GL + V W+++ MG ++H+I +FL Sbjct: 244 ARAWP-------KMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFL 296 Query: 744 YRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTE 800 RN +R +++ P TF + + + G +L+ CH++ H H GME V S E Sbjct: 297 VRN---HRQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPE 350 Score = 87.4 bits (215), Expect = 5e-17 Identities = 40/121 (33%), Positives = 64/121 (52%), Gaps = 3/121 (2%) Query: 2 HAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRG---HHTDVANI 58 HAING++ LP L M +R+ W+L MG+ ++H+ F G + T R + + N+ Sbjct: 1938 HAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMALYNL 1997 Query: 59 FPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIE 118 +P F T EM+P + G W + C + H GM L+ V S P+ + +G +R + I Sbjct: 1998 YPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNKCQTPLGMASGHIRDFQIT 2057 Query: 119 A 119 A Sbjct: 2058 A 2058 >gi|105990535 coagulation factor V precursor [Homo sapiens] Length = 2224 Score = 367 bits (943), Expect = e-101 Identities = 230/693 (33%), Positives = 344/693 (49%), Gaps = 85/693 (12%) Query: 111 KVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQ 170 ++RQ+++ A I W Y P + S ++ ++ K+ Y ++ Sbjct: 30 QLRQFYVAAQGISWSYRPEPTNSSLNLSVT-------------------SFKKIVYREYE 70 Query: 171 DETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTV 230 +EK + G+LGP + AEVGD I+V F N+A +P S+ P G+ Y K EG Sbjct: 71 PYFKKEK---PQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGAS 127 Query: 231 YNDGSSYPGL----VAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGL 286 Y D ++P P + TY W++ +GPT DP CLT +Y+S + I D NSGL Sbjct: 128 YLD-HTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGL 186 Query: 287 VGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEG 346 +GPLL+C+ G L G QK DK+ LLF V DE+KSW Sbjct: 187 IGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSW---------------------- 224 Query: 347 FQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKG 406 Q S+ M+ +NG++ +P + +C D ++WHLLG+ + ++ + F G ++ + Sbjct: 225 SQSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVS 284 Query: 407 AAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPG-----HQATPRQR 461 A L T A M G + I H +AGM+A ++ CP + T QR Sbjct: 285 AITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQR 344 Query: 462 YQAAR-IYYIMAEEVEWDYCP--DRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAV 518 R Y+I AEEV WDY P + ++++ +Q L N +G YKK + Sbjct: 345 RHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQ---------HLDNFSNQIGKHYKKVM 395 Query: 519 FREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLES- 577 + +Y D +F +E GILGP+I+ +V D L +VFKN ASRPYS++ HGV S Sbjct: 396 YTQYEDESFTKHTVNPNMKED-GILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSP 454 Query: 578 -------------TTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKD 624 A +PGE TY+WNI E P ND+ C++ YYS VD ++D Sbjct: 455 YEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRD 514 Query: 625 MYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSI 684 + SGL+G L IC+ L+ G + D E +F +FDENKSWYLE+N+ ++P + Sbjct: 515 IASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNI-NKFCENPDEV 573 Query: 685 NLQDETFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLY 744 D F ESN M ING + ++ L + V W+ ++G ++ TIHF SF+Y Sbjct: 574 KRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIY 633 Query: 745 RNGENYRADVVDLFPGTFEVVEMVASNPGTWLM 777 G+ + D + LFP E V + N GTW++ Sbjct: 634 --GKRHE-DTLTLFPMRGESVTVTMDNVGTWML 663 Score = 257 bits (657), Expect = 3e-68 Identities = 144/347 (41%), Positives = 193/347 (55%), Gaps = 35/347 (10%) Query: 466 RIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDG 525 R YYI AEE+ WDY E + + + + YKK VFR+Y D Sbjct: 1580 RNYYIAAEEISWDYSEFVQRETDIEDSDDIPE-------------DTTYKKVVFRKYLDS 1626 Query: 526 TFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVL---------- 575 TF PR EEHLGILGP+I+ EV D++ V FKN ASRPYS+HAHG+ Sbjct: 1627 TFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTY 1686 Query: 576 -ESTTVW---PLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVG 631 + + W A +P TY W+ ERSGP SAC +W YYSAV+P KD++SGL+G Sbjct: 1687 EDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIG 1746 Query: 632 PLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETF 691 PL ICQKGIL REF LLF+ FDE KSWY E+ + S L Sbjct: 1747 PLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEK-------KSRSSWRLTSSEM 1799 Query: 692 LESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYR 751 +S++ HAING +Y +L GL MY+ E V ++L +G D+H +HFH ++ L + ++ Sbjct: 1800 KKSHEFHAINGMIY-SLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQ 1858 Query: 752 ADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSR 798 V L PG+F+ +EM AS PG WL++ V ++ AGM+T F + R Sbjct: 1859 LGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDR 1905 Score = 254 bits (650), Expect = 2e-67 Identities = 149/465 (32%), Positives = 232/465 (49%), Gaps = 25/465 (5%) Query: 1 MHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFP 60 M+ +NG+V G +P++ +CA ++WHL GM + ++ + F+GQ+L H + Sbjct: 231 MYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVSAITLVS 290 Query: 61 ATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSC-SMAPPVDLLTGKVR------ 113 AT TA M G W+IS H + GMQA +K+C + +T + R Sbjct: 291 ATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQRRHMKRW 350 Query: 114 QYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKF----FQKSSSRIGGTYWKVRYEAF 169 +YFI A E+ WDY P+ P ++ K+ S++IG Y KV Y + Sbjct: 351 EYFIAAEEVIWDYAPV-----------IPANMDKKYRSQHLDNFSNQIGKHYKKVMYTQY 399 Query: 170 QDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVF---YEKDY 226 +DE+F + + GILGP+IRA+V DT+++VF N AS+P+S+ PHGV YE + Sbjct: 400 EDESFTKHTVNPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDEV 459 Query: 227 EGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGL 286 + + ++ +P E TY+W + PT D CLT Y+S D +RD SGL Sbjct: 460 NSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGL 519 Query: 287 VGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEG 346 +G LL+C++ +L G Q+ D E +F V DENKSWY N + + D Sbjct: 520 IGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPK 579 Query: 347 FQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKG 406 F +SN M ING++ ++ L C DTV WH +GT+ ++ + F G++ + Sbjct: 580 FYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKRHED 639 Query: 407 AAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQC 451 LFP + DN+GT+ + S R +R + +C Sbjct: 640 TLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDVKC 684 Score = 197 bits (500), Expect = 5e-50 Identities = 124/341 (36%), Positives = 173/341 (50%), Gaps = 27/341 (7%) Query: 110 GKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAF 169 G R Y+I A EI WDY ++ I D + TY KV + + Sbjct: 1577 GNRRNYYIAAEEISWDYSEF---------VQRETDIEDSDDIPEDT----TYKKVVFRKY 1623 Query: 170 QDETFQEK-MHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEG 228 D TF ++ E + HLGILGP+IRAEV D IQV F N AS+P+S+ HG+ YEK EG Sbjct: 1624 LDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEG 1683 Query: 229 TVYNDGSSY---PGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSG 285 Y D S +P TY W +GP + AC W Y+SA +P +D +SG Sbjct: 1684 KTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSG 1743 Query: 286 LVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIE 345 L+GPLL+C+ G L D +EF LLF DE KSWY ++ +RL S ++ Sbjct: 1744 LIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKSRSS---WRLTSSEM- 1799 Query: 346 GFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRK 405 + S+ HAING ++S LP L M + + V HLL +G D+H V F G T+ G ++ Sbjct: 1800 --KKSHEFHAINGMIYS-LPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQ 1856 Query: 406 ---GAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMR 443 G L P +F M+ G + + + G ++ AGM+ Sbjct: 1857 HQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQ 1897 Score = 161 bits (408), Expect = 2e-39 Identities = 105/363 (28%), Positives = 172/363 (47%), Gaps = 63/363 (17%) Query: 466 RIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDG 525 R +Y+ A+ + W Y P+ + ++ L + +KK V+REY + Sbjct: 32 RQFYVAAQGISWSYRPEPT-------------------NSSLNLSVTSFKKIVYREY-EP 71 Query: 526 TFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTT------ 579 F+ +P++ G+LGP + EVGDI+ V FKN A +P S+H G+ S Sbjct: 72 YFKKEKPQSTIS---GLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGASY 128 Query: 580 ---VWPL-----AAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVG 631 +P A PG TY+W+I E SGP +D C++ IYYS + I+D SGL+G Sbjct: 129 LDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGLIG 188 Query: 632 PLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETF 691 PL IC+KG L G + D++ LLF +FDE+KSW SQ Sbjct: 189 PLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSW----------SQS----------- 227 Query: 692 LESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYR 751 S+ M+ +NG + + +T+ + ++W++L M +L +IHF+ + L +N +++ Sbjct: 228 --SSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQ-VLEQN--HHK 282 Query: 752 ADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITKE 811 + L T M G W++ H+ AGM+ + + + L IT+E Sbjct: 283 VSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITRE 342 Query: 812 TEK 814 + Sbjct: 343 QRR 345 Score = 78.2 bits (191), Expect = 3e-14 Identities = 45/123 (36%), Positives = 63/123 (51%), Gaps = 4/123 (3%) Query: 2 HAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRG---HHTDVANI 58 HAING ++ +LP L M Q+ V HL +G D+H FHGQ L G H V + Sbjct: 1806 HAINGMIY-SLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLGVWPL 1864 Query: 59 FPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIE 118 P +F T EM +PG WL++ +V + R GMQ + + P+ L TG + I+ Sbjct: 1865 LPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISDSQIK 1924 Query: 119 AHE 121 A E Sbjct: 1925 ASE 1927 >gi|22212918 ciliary neurotrophic factor receptor preproprotein [Homo sapiens] Length = 372 Score = 32.3 bits (72), Expect = 2.0 Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 10/85 (11%) Query: 227 EGTVYNDGSSYPG------LVAKPFEKVTYR-WTVPPHAGPTAQDPACLTWMYFSAADPI 279 +GT + +Y G + AK E T+ W+V HA P ++P LT AA+ Sbjct: 261 DGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLT-TEAQAAETT 319 Query: 280 RDTNSGLVGP--LLVCRAGALGADG 302 T S L P +C G LG+ G Sbjct: 320 TSTTSSLAPPPTTKICDPGELGSGG 344 >gi|4502931 ciliary neurotrophic factor receptor preproprotein [Homo sapiens] Length = 372 Score = 32.3 bits (72), Expect = 2.0 Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 10/85 (11%) Query: 227 EGTVYNDGSSYPG------LVAKPFEKVTYR-WTVPPHAGPTAQDPACLTWMYFSAADPI 279 +GT + +Y G + AK E T+ W+V HA P ++P LT AA+ Sbjct: 261 DGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLT-TEAQAAETT 319 Query: 280 RDTNSGLVGP--LLVCRAGALGADG 302 T S L P +C G LG+ G Sbjct: 320 TSTTSSLAPPPTTKICDPGELGSGG 344 >gi|73760405 thymopoietin isoform beta [Homo sapiens] Length = 454 Score = 32.0 bits (71), Expect = 2.6 Identities = 18/49 (36%), Positives = 25/49 (51%) Query: 516 KAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNAS 564 +A+ RE T G+ R PR R EH I GP+I T++ +N S Sbjct: 244 QALTRESTRGSRRTPRKRVETSEHFRIDGPVISESTPIAETIMASSNES 292 >gi|169203189 PREDICTED: hypothetical protein LOC338667 [Homo sapiens] Length = 859 Score = 31.6 bits (70), Expect = 3.4 Identities = 26/99 (26%), Positives = 44/99 (44%), Gaps = 15/99 (15%) Query: 555 LTVVFKNNASRPYSVHAHGVLESTTV---WPLAAEPGEVVTYQWNIPERSGPGPNDSACV 611 LT+ + +VH E+ T+ WP P ++ QW P+ GPGP + V Sbjct: 380 LTIYYPPEGQPSCAVHPSS--EAVTLLCAWPGGLPPAQL---QWEGPQ--GPGPTAPSNV 432 Query: 612 SWIYYSAVDPIKDMYS-----GLVGPLAICQKGILEPHG 645 +W + +A P +++ + P A+C + EP G Sbjct: 433 TWSHAAAQLPSGSVFTCTGQHPALAPPALCTVMLWEPLG 471 >gi|169203683 PREDICTED: hypothetical protein LOC338667 [Homo sapiens] Length = 859 Score = 30.8 bits (68), Expect = 5.9 Identities = 20/70 (28%), Positives = 33/70 (47%), Gaps = 10/70 (14%) Query: 581 WPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYS-----GLVGPLAI 635 WP P ++ QW P+ GPGP + V+W + +A P +++ + P A+ Sbjct: 407 WPGGLPPAQL---QWEGPQ--GPGPTAPSNVTWSHAAAQLPSGSVFTCTGQHPALAPPAL 461 Query: 636 CQKGILEPHG 645 C + EP G Sbjct: 462 CTVMLWEPLG 471 >gi|169202109 PREDICTED: hypothetical protein LOC338667 [Homo sapiens] Length = 859 Score = 30.8 bits (68), Expect = 5.9 Identities = 20/70 (28%), Positives = 33/70 (47%), Gaps = 10/70 (14%) Query: 581 WPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYS-----GLVGPLAI 635 WP P ++ QW P+ GPGP + V+W + +A P +++ + P A+ Sbjct: 407 WPGGLPPAQL---QWEGPQ--GPGPTAPSNVTWSHAAAQLPSGSVFTCTGQHPALAPPAL 461 Query: 636 CQKGILEPHG 645 C + EP G Sbjct: 462 CTVMLWEPLG 471 >gi|4505941 DNA directed RNA polymerase II polypeptide B [Homo sapiens] Length = 1174 Score = 30.4 bits (67), Expect = 7.6 Identities = 20/55 (36%), Positives = 25/55 (45%), Gaps = 5/55 (9%) Query: 416 VMAIMQPDNLGTFEI-YCQAGSHREAGMRAIYNVSQC----PGHQATPRQRYQAA 465 VM M PD+L E+ YC +H E I V P H +PR YQ+A Sbjct: 673 VMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSA 727 >gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens] Length = 825 Score = 30.4 bits (67), Expect = 7.6 Identities = 17/47 (36%), Positives = 22/47 (46%), Gaps = 4/47 (8%) Query: 69 VPWEPGTWLIS----CQVNSHFRDGMQALYKVKSCSMAPPVDLLTGK 111 VP P WL S C++N F G K+ SC+ +LLT K Sbjct: 415 VPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAK 461 >gi|148613866 tudor domain containing 10 isoform a [Homo sapiens] Length = 366 Score = 30.4 bits (67), Expect = 7.6 Identities = 14/41 (34%), Positives = 21/41 (51%), Gaps = 2/41 (4%) Query: 764 VVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSP 804 V +V P W MH VT+ +H M+ LF+ ++ E P Sbjct: 200 VTSIVPKTPFFWAMH--VTEALHQNMQALFSTLAQAEEQQP 238 >gi|148613864 tudor domain containing 10 isoform b [Homo sapiens] Length = 351 Score = 30.4 bits (67), Expect = 7.6 Identities = 14/41 (34%), Positives = 21/41 (51%), Gaps = 2/41 (4%) Query: 764 VVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSP 804 V +V P W MH VT+ +H M+ LF+ ++ E P Sbjct: 200 VTSIVPKTPFFWAMH--VTEALHQNMQALFSTLAQAEEQQP 238 >gi|62420886 discoidin domain receptor family, member 2 precursor [Homo sapiens] Length = 855 Score = 30.0 bits (66), Expect = 10.0 Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 3/52 (5%) Query: 831 MQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDD 882 +++ N +L LVAI LL +++ ++W Q Q+ L + R +LDD Sbjct: 391 LKVDDSNTRILIGCLVAIIFILLAIIVI---ILWRQFWQKMLEKASRRMLDD 439 >gi|62420884 discoidin domain receptor family, member 2 precursor [Homo sapiens] Length = 855 Score = 30.0 bits (66), Expect = 10.0 Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 3/52 (5%) Query: 831 MQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDD 882 +++ N +L LVAI LL +++ ++W Q Q+ L + R +LDD Sbjct: 391 LKVDDSNTRILIGCLVAIIFILLAIIVI---ILWRQFWQKMLEKASRRMLDD 439 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.137 0.431 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 36,837,131 Number of Sequences: 37866 Number of extensions: 1719015 Number of successful extensions: 3378 Number of sequences better than 10.0: 19 Number of HSP's better than 10.0 without gapping: 8 Number of HSP's successfully gapped in prelim test: 11 Number of HSP's that attempted gapping in prelim test: 3166 Number of HSP's gapped (non-prelim): 40 length of query: 891 length of database: 18,247,518 effective HSP length: 111 effective length of query: 780 effective length of database: 14,044,392 effective search space: 10954625760 effective search space used: 10954625760 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.