Search of human proteins with 13899221

Search of human proteins with 13899221

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13899221 melanoma-derived leucine zipper, extra-nuclear
factor [Homo sapiens]
         (508 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13899221 melanoma-derived leucine zipper, extra-nuclear facto...  1004   0.0  
gi|150456463 gasdermin 1 [Homo sapiens]                               176   4e-44
gi|83320070 gasdermin D [Homo sapiens]                                174   1e-43
gi|109689711 gasdermin-like isoform 2 [Homo sapiens]                   49   1e-05
gi|109689703 gasdermin-like isoform 1 [Homo sapiens]                   48   2e-05
gi|148886654 polydom [Homo sapiens]                                    33   0.80 
gi|157426887 dedicator of cytokinesis 6 [Homo sapiens]                 32   1.8  
gi|11968009 SIL1 protein precursor [Homo sapiens]                      31   3.0  
gi|83641896 SIL1 protein precursor [Homo sapiens]                      31   3.0  
gi|13384602 hypothetical protein LOC63895 [Homo sapiens]               30   6.8  
gi|38348286 tumor protein p63 regulated 1 [Homo sapiens]               29   8.8  

>gi|13899221 melanoma-derived leucine zipper, extra-nuclear factor
           [Homo sapiens]
          Length = 508

 Score = 1004 bits (2596), Expect = 0.0
 Identities = 508/508 (100%), Positives = 508/508 (100%)

Query: 1   MPSMLERISKNLVKEIGSKDLTPVKYLLSATKLRQFVILRKKKDSRSSFWEQSDYVPVEF 60
           MPSMLERISKNLVKEIGSKDLTPVKYLLSATKLRQFVILRKKKDSRSSFWEQSDYVPVEF
Sbjct: 1   MPSMLERISKNLVKEIGSKDLTPVKYLLSATKLRQFVILRKKKDSRSSFWEQSDYVPVEF 60

Query: 61  SLNDILEPSSSVLETVVTGPFHFSDIMIQKHKADMGVNVGIEVSVSGEASVDHGCSLEFQ 120
           SLNDILEPSSSVLETVVTGPFHFSDIMIQKHKADMGVNVGIEVSVSGEASVDHGCSLEFQ
Sbjct: 61  SLNDILEPSSSVLETVVTGPFHFSDIMIQKHKADMGVNVGIEVSVSGEASVDHGCSLEFQ 120

Query: 121 IVTIPSPNLEDFQKRKLLDPEPSFLKECRRRGDNLYVVTEAVELINNTVLYDSSSVNILG 180
           IVTIPSPNLEDFQKRKLLDPEPSFLKECRRRGDNLYVVTEAVELINNTVLYDSSSVNILG
Sbjct: 121 IVTIPSPNLEDFQKRKLLDPEPSFLKECRRRGDNLYVVTEAVELINNTVLYDSSSVNILG 180

Query: 181 KIALWITYGKGQGQGESLRVKKKALTLQKGMVMAYKRKQLVIKEKAILISDDDEQRTFQD 240
           KIALWITYGKGQGQGESLRVKKKALTLQKGMVMAYKRKQLVIKEKAILISDDDEQRTFQD
Sbjct: 181 KIALWITYGKGQGQGESLRVKKKALTLQKGMVMAYKRKQLVIKEKAILISDDDEQRTFQD 240

Query: 241 EYEISEMVGYCAARSEGLLPSFHTISPTLFNASSNDMKLKPELFLTQQFLSGHLPKYEQV 300
           EYEISEMVGYCAARSEGLLPSFHTISPTLFNASSNDMKLKPELFLTQQFLSGHLPKYEQV
Sbjct: 241 EYEISEMVGYCAARSEGLLPSFHTISPTLFNASSNDMKLKPELFLTQQFLSGHLPKYEQV 300

Query: 301 HILPVGRIEEPFWQNFKHLQEEVFQKIKTLAQLSKDVQDVMFYSILAMLRDRGALQDLMN 360
           HILPVGRIEEPFWQNFKHLQEEVFQKIKTLAQLSKDVQDVMFYSILAMLRDRGALQDLMN
Sbjct: 301 HILPVGRIEEPFWQNFKHLQEEVFQKIKTLAQLSKDVQDVMFYSILAMLRDRGALQDLMN 360

Query: 361 MLELDSSGHLDGPGGAILKKLQQDSNHAWFNPKDPILYLLEAIMVLSDFQHDLLACSMEK 420
           MLELDSSGHLDGPGGAILKKLQQDSNHAWFNPKDPILYLLEAIMVLSDFQHDLLACSMEK
Sbjct: 361 MLELDSSGHLDGPGGAILKKLQQDSNHAWFNPKDPILYLLEAIMVLSDFQHDLLACSMEK 420

Query: 421 RILLQQQELVRSILEPNFRYPWSIPFTLKPELLAPLQSEGLAITYGLLEECGLRMELDNP 480
           RILLQQQELVRSILEPNFRYPWSIPFTLKPELLAPLQSEGLAITYGLLEECGLRMELDNP
Sbjct: 421 RILLQQQELVRSILEPNFRYPWSIPFTLKPELLAPLQSEGLAITYGLLEECGLRMELDNP 480

Query: 481 RSTWDVEAKMPLSALYGTLSLLQQLAEA 508
           RSTWDVEAKMPLSALYGTLSLLQQLAEA
Sbjct: 481 RSTWDVEAKMPLSALYGTLSLLQQLAEA 508


>gi|150456463 gasdermin 1 [Homo sapiens]
          Length = 445

 Score =  176 bits (446), Expect = 4e-44
 Identities = 155/510 (30%), Positives = 244/510 (47%), Gaps = 71/510 (13%)

Query: 3   SMLERISKNLVKEIGSK-DLTPVKYLLSATKLRQFVILRKKKDSRSSFWEQSDYVPVEFS 61
           +M E +++ L +++  + DLTP+  L+   +   F ++ +K+ S + FW  + YV  +++
Sbjct: 2   TMFENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRKS-TLFWG-ARYVRTDYT 59

Query: 62  LNDILEPSSSVLETVVTGPFHFSDIMIQKHKADMGVNVGIEVSVSGEASVDHGCSLEFQI 121
           L D+LEP SS  +   TG F F +++  + + D  V+V   V V G A +    +LE Q 
Sbjct: 60  LLDVLEPGSSPSDPTDTGNFGFKNMLDTRVEGD--VDVPKTVKVKGTAGLSQNSTLEVQT 117

Query: 122 VTIPSPNLEDFQKRKLLDPEPSFLKECRRRGDNLYVVTEAVELINNTVLYDSSSVNILGK 181
           +++    LE  Q+RKL    P FLKE + +G+NLYVV E VE +    L  +        
Sbjct: 118 LSVAPKALETVQERKLAADHP-FLKEMQDQGENLYVVMEVVETVQEVTLERAGKAEACFS 176

Query: 182 IALWITYGKGQGQGESLRVKKKALTLQKGMVMAYKRKQLVIKEKAILISDDDEQRTFQDE 241
           +  +   G  QG        K+A+T+ KG V+A++ +QL++K K              DE
Sbjct: 177 LPFFAPLGL-QGSIN----HKEAVTIPKGCVLAFRVRQLMVKGK--------------DE 217

Query: 242 YEISEMVGYCAARSEGLLPSFHTISPTLFNASSNDMKLKPELFLTQQFLSGHLPKYEQVH 301
           ++I                      P + N +             Q F  G     E+V 
Sbjct: 218 WDI----------------------PHICNDN------------MQTFPPGEKSGEEKVI 243

Query: 302 ILPVGRIEEPFWQNFKHLQEEVFQKIKTLAQLSKDVQDVMFYSILAMLRDRGALQDLMNM 361
           ++    + +   + F+ L+EEV ++ + + +LS+  Q  +  S+  +L  +  LQD    
Sbjct: 244 LIQASDVGD-VHEGFRTLKEEVQRETQQVEKLSRVGQSSLLSSLSKLLGKKKELQD---- 298

Query: 362 LELDSSGHLDGPGGAILKKLQQD---SNHAWFNPKDPILYLLEAIMVLSDFQHDLLACSM 418
           LEL   G LD      L+ L +D   S  A       ILY + A+  LS+ Q  LL  SM
Sbjct: 299 LELALEGALDKGHEVTLEALPKDVLLSKEA----VGAILYFVGALTELSEAQQKLLVKSM 354

Query: 419 EKRILLQQQELVRSILEPNFRYPWSIPFTLKPELLAPLQSEGLAITYGLLEECGLRMELD 478
           EK+IL  Q +LV S +E NF       F L+PELL+ L  E L +T  L+   GL ++  
Sbjct: 355 EKKILPVQLKLVESTMEQNFLLDKEGVFPLQPELLSSLGDEELTLTEALVGLSGLEVQRS 414

Query: 479 NPRSTWDVEAKMPLSALYGTLSLLQQLAEA 508
            P+  WD +    L ALY  LSLLQQL +A
Sbjct: 415 GPQYMWDPDTLPRLCALYAGLSLLQQLTKA 444


>gi|83320070 gasdermin D [Homo sapiens]
          Length = 484

 Score =  174 bits (442), Expect = 1e-43
 Identities = 157/520 (30%), Positives = 251/520 (48%), Gaps = 52/520 (10%)

Query: 1   MPSMLERISKNLVKEIG-SKDLTPVKYLLSATKLRQFVILRKKKDSRSSFWEQSDYVPVE 59
           M S  ER+ + +V+E+    +  PV  L S+T  + + ++ +K  S S FW+   Y  V 
Sbjct: 1   MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSS-SWFWKPR-YKCVN 58

Query: 60  FSLNDILEPSSSVLETVVTGPFHFSDIMIQKHKADMGVNVGIEVSVSGEASVDHGCSLEF 119
            S+ DILEP ++  +      FHF D M  + +  + +    +  ++G A+V    S   
Sbjct: 59  LSIKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSM 118

Query: 120 QIVTIP-SPNLED--FQKRKLLDPEPSFLKECRRRGDNLYVVTEAVELINNTVLYDSSSV 176
            + ++   PN       +R L  PE   L++ R RGDN+YVVTE ++      +  +   
Sbjct: 119 NVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKR 178

Query: 177 NILGKIAL-WITYGKGQGQGESLRVKKKALTLQKGMVMAYKRKQLVI-KEKAILISDDDE 234
              G+ +L   T  +G+GQG   +  KK +T+  G  +A++  QLVI  +  +L+  D +
Sbjct: 179 EGSGRFSLPGATCLQGEGQGHLSQ--KKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKK 236

Query: 235 QRTFQDEYEISEMVGYCAARSEGL---LPSFHTISPTLFNASSNDMKLKPELFLTQQFLS 291
           QRTFQ         G+  + SEG    LPS  ++   L N                 FL+
Sbjct: 237 QRTFQPP-----ATGHKRSTSEGAWPQLPSGLSMMRCLHN-----------------FLT 274

Query: 292 GHLPKYEQVHILPVGRIEEPFWQNFKHLQEEVFQKIKTLAQLSKDVQDVMFYSILAMLRD 351
             +P             E  F ++F+ L+ EV    K L  L +++  ++   +  +LRD
Sbjct: 275 DGVPA------------EGAFTEDFQGLRAEVETISKELELLDRELCQLLLEGLEGVLRD 322

Query: 352 RGALQDLMNMLELDSS----GHLDGPGGAILKKLQQDSNHAWFNPKDPILYLLEAIMVLS 407
           + AL+ L   LE   S      LDGP GA+L+ L   S         P++YLL A+ +LS
Sbjct: 323 QLALRALEEALEQGQSLGPVEPLDGPAGAVLECLVLSSGMLVPELAIPVVYLLGALTMLS 382

Query: 408 DFQHDLLACSMEKRILLQQQELVRSILEPNFRYPWSIPFTLKPELLAPLQSEGLAITYGL 467
           + QH LLA ++E + LL   ELV S+LE +  +      +L P LL     EG A  + L
Sbjct: 383 ETQHKLLAEALESQTLLGPLELVGSLLEQSAPWQERSTMSLPPGLLGNSWGEG-APAWVL 441

Query: 468 LEECGLRMELDNPRSTWDVEAKMPLSALYGTLSLLQQLAE 507
           L+ECGL +  D P   W+ +A+  + ALY +L+LL  L++
Sbjct: 442 LDECGLELGEDTPHVCWEPQAQGRMCALYASLALLSGLSQ 481


>gi|109689711 gasdermin-like isoform 2 [Homo sapiens]
          Length = 394

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 60/256 (23%), Positives = 110/256 (42%), Gaps = 22/256 (8%)

Query: 1   MPSMLERISKNLVKEIGSK-DLTPVKYLLSATKLRQFVILRKKKDSRSSFWEQSDYVPVE 59
           M S+ E I++ +VKE+ +  D+  V+ L+ A + R F ++ +K+    +F+    Y    
Sbjct: 1   MFSVFEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKR----TFFGCRHYT-TG 55

Query: 60  FSLNDILEPSSSV----LETVVTGP-FHFSDIMIQKHKADMGVNVGIEVSVSGEASVDHG 114
            +L DIL+         L++ + G    F  +       ++ V +  E+++SG     H 
Sbjct: 56  LTLMDILDTDGDKWLDELDSGLQGQKAEFQILDNVDSTGELIVRLPKEITISGSFQGFHH 115

Query: 115 CSLEFQIVTIPSPNLEDFQKRKLLDPEPSFLKECRRRGDNLYVVTEAVELINNTVLYDSS 174
             ++     I    L   + RKL    P   +    R +NLY+VTE +E +    L    
Sbjct: 116 QKIKISENRISQQYLATLENRKLKRELPFSFRSINTR-ENLYLVTETLETVKEETLKSDR 174

Query: 175 SVNILGKIALWITYGKGQGQGESLRVKKKALTLQKGMVMAYKRKQLVIKEKAILISD--D 232
                 +I+      K +GQ E        +T+    V++Y+ KQLV   K  +      
Sbjct: 175 QYKFWSQISQGHLSYKHKGQRE--------VTIPPNRVLSYRVKQLVFPNKETMRKSLGS 226

Query: 233 DEQRTFQDEYEISEMV 248
           ++ R  +++ E  E V
Sbjct: 227 EDSRNMKEKLEDMESV 242


>gi|109689703 gasdermin-like isoform 1 [Homo sapiens]
          Length = 403

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 57/237 (24%), Positives = 102/237 (43%), Gaps = 20/237 (8%)

Query: 1   MPSMLERISKNLVKEIGSK-DLTPVKYLLSATKLRQFVILRKKKDSRSSFWEQSDYVPVE 59
           M S+ E I++ +VKE+ +  D+  V+ L+ A + R F ++ +K+    +F+    Y    
Sbjct: 1   MFSVFEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKR----TFFGCRHYT-TG 55

Query: 60  FSLNDILEPSSSV----LETVVTGP-FHFSDIMIQKHKADMGVNVGIEVSVSGEASVDHG 114
            +L DIL+         L++ + G    F  +       ++ V +  E+++SG     H 
Sbjct: 56  LTLMDILDTDGDKWLDELDSGLQGQKAEFQILDNVDSTGELIVRLPKEITISGSFQGFHH 115

Query: 115 CSLEFQIVTIPSPNLEDFQKRKLLDPEPSFLKECRRRGDNLYVVTEAVELINNTVLYDSS 174
             ++     I    L   + RKL    P   +    R +NLY+VTE +E +    L    
Sbjct: 116 QKIKISENRISQQYLATLENRKLKRELPFSFRSINTR-ENLYLVTETLETVKEETLKSDR 174

Query: 175 SVNILGKIALWITYGKGQGQGESLRVKKKALTLQKGMVMAYKRKQLVIKEKAILISD 231
                 +I+      K +GQ E        +T+    V++Y+ KQLV   K  +  D
Sbjct: 175 QYKFWSQISQGHLSYKHKGQRE--------VTIPPNRVLSYRVKQLVFPNKETMKKD 223


>gi|148886654 polydom [Homo sapiens]
          Length = 3571

 Score = 32.7 bits (73), Expect = 0.80
 Identities = 18/47 (38%), Positives = 29/47 (61%), Gaps = 3/47 (6%)

Query: 232  DDEQRT-FQDEYEISEMVGYCAARSEGLLPSFHTISPTLFNASSNDM 277
            + EQ T F  ++E+S + GY     +G+LPS H ++ T +  SS+DM
Sbjct: 1419 ETEQSTGFNLDFEVSGIYGYVML--DGMLPSLHALTCTFWMKSSDDM 1463


>gi|157426887 dedicator of cytokinesis 6 [Homo sapiens]
          Length = 2047

 Score = 31.6 bits (70), Expect = 1.8
 Identities = 39/190 (20%), Positives = 76/190 (40%), Gaps = 28/190 (14%)

Query: 157  VVTEAVELINNTVLYDSSSVNILGKIALWITYGKGQGQGESLRVKKKALTLQKGMVMAYK 216
            VV + +E+I  TV+   +  ++LG +   + Y  G  Q         AL LQ G+     
Sbjct: 1391 VVLDTLEIIVQTVMLSEARESVLGAVLKVVLYSLGSAQ--------SALFLQHGLA---T 1439

Query: 217  RKQLVIKEKAILISDDDEQRTFQDEYEISEMVGYCAARSEGL----LPSFHTISPTLFNA 272
            ++ LV K   +L  +D E            ++ +C +R   +      S + +    F  
Sbjct: 1440 QRALVSKFPELLFEEDTELCADL----CLRLLRHCGSRISTIRTHASASLYLLMRQNFEI 1495

Query: 273  SSNDMKLKPELFLTQQFLSGHLPKYEQVHILPVGRIEEPFWQNFKHLQEEVFQKIKTLAQ 332
              N  ++K ++ ++   L G    + + H      +         + +E++  +  T A+
Sbjct: 1496 GHNFARVKMQVTMSLSSLVGTTQNFSEEH------LRRSLKTILTYAEEDMGLRDSTFAE 1549

Query: 333  LSKDVQDVMF 342
                VQD+MF
Sbjct: 1550 ---QVQDLMF 1556


>gi|11968009 SIL1 protein precursor [Homo sapiens]
          Length = 461

 Score = 30.8 bits (68), Expect = 3.0
 Identities = 33/127 (25%), Positives = 58/127 (45%), Gaps = 14/127 (11%)

Query: 269 LFNASSNDMKLKPELFLTQQFLSGHLPKYEQVHILPVGRIEEPFWQNFKHL--------Q 320
           L++  +  M  + E  LTQ+     L +Y QVH+LP G  E+ + +   HL        +
Sbjct: 336 LYDLVTEKMFAEEEAELTQEMSPEKLQQYRQVHLLP-GLWEQGWCEITAHLLALPEHDAR 394

Query: 321 EEVFQKIKTLAQLSKD--VQDVMFYSILAMLRDRGALQDLMNMLELDSSGH---LDGPGG 375
           E+V Q +  L    +D   QD      LA L+    +   + + + +  G+   L G   
Sbjct: 395 EKVLQTLGVLLTTCRDRYRQDPQLGRTLASLQAEYQVLASLELQDGEDEGYFQELLGSVN 454

Query: 376 AILKKLQ 382
           ++LK+L+
Sbjct: 455 SLLKELR 461


>gi|83641896 SIL1 protein precursor [Homo sapiens]
          Length = 461

 Score = 30.8 bits (68), Expect = 3.0
 Identities = 33/127 (25%), Positives = 58/127 (45%), Gaps = 14/127 (11%)

Query: 269 LFNASSNDMKLKPELFLTQQFLSGHLPKYEQVHILPVGRIEEPFWQNFKHL--------Q 320
           L++  +  M  + E  LTQ+     L +Y QVH+LP G  E+ + +   HL        +
Sbjct: 336 LYDLVTEKMFAEEEAELTQEMSPEKLQQYRQVHLLP-GLWEQGWCEITAHLLALPEHDAR 394

Query: 321 EEVFQKIKTLAQLSKD--VQDVMFYSILAMLRDRGALQDLMNMLELDSSGH---LDGPGG 375
           E+V Q +  L    +D   QD      LA L+    +   + + + +  G+   L G   
Sbjct: 395 EKVLQTLGVLLTTCRDRYRQDPQLGRTLASLQAEYQVLASLELQDGEDEGYFQELLGSVN 454

Query: 376 AILKKLQ 382
           ++LK+L+
Sbjct: 455 SLLKELR 461


>gi|13384602 hypothetical protein LOC63895 [Homo sapiens]
          Length = 544

 Score = 29.6 bits (65), Expect = 6.8
 Identities = 21/76 (27%), Positives = 35/76 (46%), Gaps = 3/76 (3%)

Query: 2   PSMLERISKNLVKEIGSKDLTPVKYLLSATKLRQFVILRKKKDSRSSFWEQSDYVPVEFS 61
           P  +E+I    VK     +  P+K LLS        I+   +D+ + +   S++  +  +
Sbjct: 372 PVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITII-LSRDNTTKY--NSEWWVLNLT 428

Query: 62  LNDILEPSSSVLETVV 77
            N I  P+S  LE VV
Sbjct: 429 GNRIYNPNSQALELVV 444


>gi|38348286 tumor protein p63 regulated 1 [Homo sapiens]
          Length = 275

 Score = 29.3 bits (64), Expect = 8.8
 Identities = 37/133 (27%), Positives = 56/133 (42%), Gaps = 19/133 (14%)

Query: 353 GALQDLMNMLELDSSGHLDGPGGAILKK--LQQDSNHAWFNPKDPILYLLEAIMVLSDFQ 410
           GA++  M     D  GH+    G  ++   L    +H W N K+ IL + +  +++  + 
Sbjct: 72  GAIETAME----DLKGHVAETSGETIQGFWLLTKIDH-WNNEKERILLVTDKTLLICKYD 126

Query: 411 HDLLACSMEKRILLQQQELVRSILEPNFRYPWSIPFTLKPELLAPLQSEGLAITYGLLEE 470
             +L+C   +RI L     V  I    F +P           L   Q EGL I +G  EE
Sbjct: 127 FIMLSCVQLQRIPL---SAVYRICLGKFTFPGM--------SLDKRQGEGLRIYWGSPEE 175

Query: 471 CGLRMELDNPRST 483
             L +   NP ST
Sbjct: 176 QSL-LSRWNPWST 187


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,518,084
Number of Sequences: 37866
Number of extensions: 810256
Number of successful extensions: 1959
Number of sequences better than 10.0: 11
Number of HSP's better than 10.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 1948
Number of HSP's gapped (non-prelim): 12
length of query: 508
length of database: 18,247,518
effective HSP length: 107
effective length of query: 401
effective length of database: 14,195,856
effective search space: 5692538256
effective search space used: 5692538256
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.