Search of human proteins with 66793392

Search of human proteins with 66793392

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|66793392 Na+/H+ exchanger domain containing 1 isoform 1
[Homo sapiens]
         (515 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|66793392 Na+/H+ exchanger domain containing 1 isoform 1 [Homo...  1016   0.0  
gi|154937338 Na+/H+ exchanger domain containing 1 isoform 2 [Hom...   878   0.0  
gi|47271479 Na+/H+ exchanger domain containing 2 [Homo sapiens]       563   e-160
gi|169194717 PREDICTED: similar to Na+/H+ exchanger domain conta...   473   e-133
gi|169194736 PREDICTED: similar to hCG1988827 [Homo sapiens]           86   6e-17
gi|89030918 PREDICTED: similar to hCG1988827 [Homo sapiens]            86   6e-17
gi|239744762 PREDICTED: hypothetical protein XP_002343263 [Homo ...    32   1.1  
gi|239755937 PREDICTED: similar to Os05g0242100 [Homo sapiens]         32   1.4  
gi|239750468 PREDICTED: similar to Os05g0242100 [Homo sapiens]         32   1.4  
gi|4507047 solute carrier family 7 (cationic amino acid transpor...    32   1.8  
gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens]          30   4.0  
gi|59853352 myosin VIIA and Rab interacting protein [Homo sapiens]     29   9.0  

>gi|66793392 Na+/H+ exchanger domain containing 1 isoform 1 [Homo
           sapiens]
          Length = 515

 Score = 1016 bits (2626), Expect = 0.0
 Identities = 515/515 (100%), Positives = 515/515 (100%)

Query: 1   MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAHEETKTVLSDTEEIKPQTKKETYISCPL 60
           MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAHEETKTVLSDTEEIKPQTKKETYISCPL
Sbjct: 1   MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAHEETKTVLSDTEEIKPQTKKETYISCPL 60

Query: 61  RGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLV 120
           RGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLV
Sbjct: 61  RGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLV 120

Query: 121 PPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHL 180
           PPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHL
Sbjct: 121 PPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHL 180

Query: 181 KVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENG 240
           KVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENG
Sbjct: 181 KVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENG 240

Query: 241 YGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVL 300
           YGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVL
Sbjct: 241 YGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVL 300

Query: 301 GFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQ 360
           GFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQ
Sbjct: 301 GFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQ 360

Query: 361 EKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLM 420
           EKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLM
Sbjct: 361 EKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLM 420

Query: 421 CFAGFSFKEKIFIALAWMPKATVQAVLGPLALETARVSAPHLEPYAKDVMTVAFLAILIT 480
           CFAGFSFKEKIFIALAWMPKATVQAVLGPLALETARVSAPHLEPYAKDVMTVAFLAILIT
Sbjct: 421 CFAGFSFKEKIFIALAWMPKATVQAVLGPLALETARVSAPHLEPYAKDVMTVAFLAILIT 480

Query: 481 APNGALLMGILGPKMLTRHYDPSKIKLQLSTLEHH 515
           APNGALLMGILGPKMLTRHYDPSKIKLQLSTLEHH
Sbjct: 481 APNGALLMGILGPKMLTRHYDPSKIKLQLSTLEHH 515


>gi|154937338 Na+/H+ exchanger domain containing 1 isoform 2 [Homo
           sapiens]
          Length = 475

 Score =  878 bits (2268), Expect = 0.0
 Identities = 444/444 (100%), Positives = 444/444 (100%)

Query: 1   MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAHEETKTVLSDTEEIKPQTKKETYISCPL 60
           MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAHEETKTVLSDTEEIKPQTKKETYISCPL
Sbjct: 1   MHTTESKNEHLEDENFQTSTTPQSLIDPNNTAHEETKTVLSDTEEIKPQTKKETYISCPL 60

Query: 61  RGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLV 120
           RGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLV
Sbjct: 61  RGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLV 120

Query: 121 PPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHL 180
           PPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHL
Sbjct: 121 PPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHL 180

Query: 181 KVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENG 240
           KVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENG
Sbjct: 181 KVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENG 240

Query: 241 YGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVL 300
           YGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVL
Sbjct: 241 YGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVL 300

Query: 301 GFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQ 360
           GFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQ
Sbjct: 301 GFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQ 360

Query: 361 EKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLM 420
           EKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLM
Sbjct: 361 EKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCVRILTTYLLM 420

Query: 421 CFAGFSFKEKIFIALAWMPKATVQ 444
           CFAGFSFKEKIFIALAWMPKATVQ
Sbjct: 421 CFAGFSFKEKIFIALAWMPKATVQ 444


>gi|47271479 Na+/H+ exchanger domain containing 2 [Homo sapiens]
          Length = 537

 Score =  563 bits (1452), Expect = e-160
 Identities = 274/466 (58%), Positives = 357/466 (76%), Gaps = 7/466 (1%)

Query: 34  EETKTVLSDTEEIKPQTKKETYISCPLRGVLNVIITNGVILFVIWCMTWSILGSEALPGG 93
           +ET T  +  + ++        ++CP  G+L+ +ITN  I+ ++W + WSI GSE LPGG
Sbjct: 60  QETPTEANHVQRLRQM------LACPPHGLLDRVITNVTIIVLLWAVVWSITGSECLPGG 113

Query: 94  NLFGLFIIFYSAIIGGKILQLIRIPLVPPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWS 153
           NLFG+ I+FY AIIGGK+L LI++P +PPLP LLGMLLAGF IRN+P IN++V + + WS
Sbjct: 114 NLFGIIILFYCAIIGGKLLGLIKLPTLPPLPSLLGMLLAGFLIRNIPVINDNVQIKHKWS 173

Query: 154 SILRSIALTIILIRAGLGLDPQALRHLKVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQW 213
           S LRSIAL+IIL+RAGLGLD +AL+ LK VC RL++GPC++EA  +A+ +H+++  PWQW
Sbjct: 174 SSLRSIALSIILVRAGLGLDSKALKKLKGVCVRLSMGPCIVEACTSALLAHYLLGLPWQW 233

Query: 214 AFLLGFVLGAVSPAVVVPYMMVLQENGYGVEEGIPTLLMAASSMDDILAITGFNTCLSIV 273
            F+LGFVLGAVSPAVVVP M++LQ  GYGVE+G+PTLLMAA S DDILAITGFNTCL I 
Sbjct: 234 GFILGFVLGAVSPAVVVPSMLLLQGGGYGVEKGVPTLLMAAGSFDDILAITGFNTCLGIA 293

Query: 274 FSSGGILNNAIASIRNVCISLLAGIVLGFFVRYFPSEDQKKLTLKRGFLVLTMCVSAVLG 333
           FS+G  + N +  +  V I +  G VLGFF++YFPS DQ KL  KR FLVL + V AV  
Sbjct: 294 FSTGSTVFNVLRGVLEVVIGVATGSVLGFFIQYFPSRDQDKLVCKRTFLVLGLSVLAVFS 353

Query: 334 SQRIGLHGSGGLCTLVLSFIAGTKWSQEKMKVQKIITTVWDIFQPLLFGLVGAEVSVSSL 393
           S   G  GSGGLCTLV++F+AG  W+ EK +V+KII   WDIFQPLLFGL+GAEVS++SL
Sbjct: 354 SVHFGFPGSGGLCTLVMAFLAGMGWTSEKAEVEKIIAVAWDIFQPLLFGLIGAEVSIASL 413

Query: 394 ESNIVGISVATLSLALCVRILTTYLLMCFAGFSFKEKIFIALAWMPKATVQAVLGPLALE 453
               VG+ VAT+ +A+ +RILTT+L++CFAGF+ KEKIFI+ AW+PKATVQA +G +AL+
Sbjct: 414 RPETVGLCVATVGIAVLIRILTTFLMVCFAGFNLKEKIFISFAWLPKATVQAAIGSVALD 473

Query: 454 TARV-SAPHLEPYAKDVMTVAFLAILITAPNGALLMGILGPKMLTR 498
           TAR      LE Y  DV+TVAFL+ILITAP G+LL+G+LGP++L +
Sbjct: 474 TARSHGEKQLEDYGMDVLTVAFLSILITAPIGSLLIGLLGPRLLQK 519


>gi|169194717 PREDICTED: similar to Na+/H+ exchanger domain
           containing 1 [Homo sapiens]
          Length = 271

 Score =  473 bits (1216), Expect = e-133
 Identities = 246/286 (86%), Positives = 249/286 (87%), Gaps = 23/286 (8%)

Query: 80  MTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLIRIPLVPPLPPLLGMLLAGFTIRNV 139
           MTWSILGSEALPGGNLFGL IIFYSAIIGGK LQLIRIPLVPP PPLLGMLLAGFTIRNV
Sbjct: 1   MTWSILGSEALPGGNLFGLLIIFYSAIIGGKNLQLIRIPLVPPFPPLLGMLLAGFTIRNV 60

Query: 140 PFINEHVHVPNTWSSILRSIALTIILIRAGLGLDPQALRHLKVVCFRLAVGPCLMEASAA 199
           PFINEHVHVPN WSSILRSIAL IILIRAGLGLDPQA RHLKVVCFRLAVGPCLMEASAA
Sbjct: 61  PFINEHVHVPNAWSSILRSIALNIILIRAGLGLDPQAWRHLKVVCFRLAVGPCLMEASAA 120

Query: 200 AVFSHFIMKFPWQWAFLLGFVLGAVSPAVVVPYMMVLQENGYGVEEGIPTLLMAASSMDD 259
           AVFSHFIMKFPWQWA LLGFVLGAVSP VVV YMMVLQENGYGVEE IPTLLMAASSMDD
Sbjct: 121 AVFSHFIMKFPWQWAILLGFVLGAVSPVVVVLYMMVLQENGYGVEEDIPTLLMAASSMDD 180

Query: 260 ILAITGFNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVLGFFVRYFPSEDQKKLTLKR 319
           ILAITGFNTCLSIVF SGG+LNNAIASIRN                       KKLTLKR
Sbjct: 181 ILAITGFNTCLSIVFFSGGMLNNAIASIRN-----------------------KKLTLKR 217

Query: 320 GFLVLTMCVSAVLGSQRIGLHGSGGLCTLVLSFIAGTKWSQEKMKV 365
           GFLVLT CVSAVL SQRIGLHGSGGLCTLVLSFIAGTKWSQEK+ +
Sbjct: 218 GFLVLTTCVSAVLSSQRIGLHGSGGLCTLVLSFIAGTKWSQEKVNI 263


>gi|169194736 PREDICTED: similar to hCG1988827 [Homo sapiens]
          Length = 92

 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 43/44 (97%), Positives = 43/44 (97%)

Query: 234 MVLQENGYGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSG 277
           MVLQENGYGVEE IPTLLMAASSMDDILAITGFNTCLSIVFSSG
Sbjct: 1   MVLQENGYGVEEDIPTLLMAASSMDDILAITGFNTCLSIVFSSG 44


>gi|89030918 PREDICTED: similar to hCG1988827 [Homo sapiens]
          Length = 92

 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 43/44 (97%), Positives = 43/44 (97%)

Query: 234 MVLQENGYGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSG 277
           MVLQENGYGVEE IPTLLMAASSMDDILAITGFNTCLSIVFSSG
Sbjct: 1   MVLQENGYGVEEDIPTLLMAASSMDDILAITGFNTCLSIVFSSG 44


>gi|239744762 PREDICTED: hypothetical protein XP_002343263 [Homo
           sapiens]
          Length = 761

 Score = 32.3 bits (72), Expect = 1.1
 Identities = 15/37 (40%), Positives = 21/37 (56%)

Query: 307 FPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSG 343
           FPS+DQ  L  +  FLVL +C+  + G  R+ L   G
Sbjct: 306 FPSKDQPLLVRRDAFLVLDLCLDILNGVTRLHLESDG 342



 Score = 30.8 bits (68), Expect = 3.1
 Identities = 14/37 (37%), Positives = 20/37 (54%)

Query: 307 FPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSG 343
           FPS+DQ  L  +  FLVL +C+  + G  R+     G
Sbjct: 154 FPSKDQPLLVRRDAFLVLDLCLDILNGVTRLHFESDG 190



 Score = 30.8 bits (68), Expect = 3.1
 Identities = 14/37 (37%), Positives = 20/37 (54%)

Query: 307 FPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSG 343
           FPS+DQ  L  +  FLVL +C+  + G  R+     G
Sbjct: 230 FPSKDQPLLVRRDAFLVLDLCLDILNGVTRLHFESDG 266


>gi|239755937 PREDICTED: similar to Os05g0242100 [Homo sapiens]
          Length = 609

 Score = 32.0 bits (71), Expect = 1.4
 Identities = 15/37 (40%), Positives = 21/37 (56%)

Query: 307 FPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSG 343
           FPS+DQ  L  +  FLVL +C+  + G  R+ L   G
Sbjct: 154 FPSKDQPLLIRRDAFLVLDLCLDILNGVTRLHLESDG 190


>gi|239750468 PREDICTED: similar to Os05g0242100 [Homo sapiens]
          Length = 758

 Score = 32.0 bits (71), Expect = 1.4
 Identities = 15/37 (40%), Positives = 21/37 (56%)

Query: 307 FPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSG 343
           FPS+DQ  L  +  FLVL +C+  + G  R+ L   G
Sbjct: 442 FPSKDQPLLIRRDAFLVLDLCLDILNGVTRLHLESDG 478



 Score = 30.8 bits (68), Expect = 3.1
 Identities = 14/37 (37%), Positives = 21/37 (56%)

Query: 307 FPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSG 343
           FPS+DQ  L  +  FL+L +C+  + G   + L G G
Sbjct: 214 FPSKDQPLLIRRDAFLILDLCLDILDGVTGLHLEGDG 250



 Score = 30.8 bits (68), Expect = 3.1
 Identities = 14/37 (37%), Positives = 20/37 (54%)

Query: 307 FPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSG 343
           FPS+DQ  L  +  FLVL +C+  + G  R+     G
Sbjct: 290 FPSKDQPLLVRRDAFLVLDLCLDILNGVTRLHFESDG 326



 Score = 30.8 bits (68), Expect = 3.1
 Identities = 14/37 (37%), Positives = 20/37 (54%)

Query: 307 FPSEDQKKLTLKRGFLVLTMCVSAVLGSQRIGLHGSG 343
           FPS+DQ  L  +  FLVL +C+  + G  R+     G
Sbjct: 366 FPSKDQPLLVRRDAFLVLDLCLDILNGVTRLHFESDG 402


>gi|4507047 solute carrier family 7 (cationic amino acid
           transporter, y+ system), member 1 [Homo sapiens]
          Length = 629

 Score = 31.6 bits (70), Expect = 1.8
 Identities = 32/126 (25%), Positives = 56/126 (44%), Gaps = 22/126 (17%)

Query: 13  DENFQTSTTPQSLIDPNNTAHEETKTVLSDTEEIKPQTKKETYISCPLRGVLNVIITNGV 72
           D+N   ST    L           KT+LS      P+  + + IS    G++  I T+ +
Sbjct: 454 DQNELASTNDSQLGFLPEAEMFSLKTILS------PKNMEPSKIS----GLIVNISTSLI 503

Query: 73  ILFVIWCMTWSILGSEALPGGNLFGLFIIFYSAIIGGKILQLI------------RIPLV 120
            + +I     ++LG EAL  G L+ +F++  SA++   +  +I            ++P +
Sbjct: 504 AVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCAVVTGVIWRQPESKTKLSFKVPFL 563

Query: 121 PPLPPL 126
           P LP L
Sbjct: 564 PVLPIL 569


>gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens]
          Length = 4967

 Score = 30.4 bits (67), Expect = 4.0
 Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 9/54 (16%)

Query: 41   SDTEEIKPQTKKETYISCPLRGV--------LNVIITNGVILFVIWCMTWSILG 86
            SD  E K + KK++ +S  L  +        L V+ T+   L++ W MT S+LG
Sbjct: 4680 SDARE-KKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLG 4732


>gi|59853352 myosin VIIA and Rab interacting protein [Homo sapiens]
          Length = 859

 Score = 29.3 bits (64), Expect = 9.0
 Identities = 12/27 (44%), Positives = 20/27 (74%)

Query: 386 AEVSVSSLESNIVGISVATLSLALCVR 412
           AE+ +S +ES I  +++A L++A CVR
Sbjct: 751 AELQISDIESRISALTIAGLNIAPCVR 777


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.140    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,497,456
Number of Sequences: 37866
Number of extensions: 770388
Number of successful extensions: 2493
Number of sequences better than 10.0: 12
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 2459
Number of HSP's gapped (non-prelim): 34
length of query: 515
length of database: 18,247,518
effective HSP length: 107
effective length of query: 408
effective length of database: 14,195,856
effective search space: 5791909248
effective search space used: 5791909248
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.