Guide to the Human Genome
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Search of human proteins with 56117836

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|56117836 speckle-type POZ protein [Homo sapiens]
         (374 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|56117834 speckle-type POZ protein [Homo sapiens]                   758   0.0  
gi|56117832 speckle-type POZ protein [Homo sapiens]                   758   0.0  
gi|56117830 speckle-type POZ protein [Homo sapiens]                   758   0.0  
gi|56117828 speckle-type POZ protein [Homo sapiens]                   758   0.0  
gi|4507183 speckle-type POZ protein [Homo sapiens]                    758   0.0  
gi|56117836 speckle-type POZ protein [Homo sapiens]                   758   0.0  
gi|48717263 speckle-type POZ protein-like [Homo sapiens]              647   0.0  
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]                     89   5e-18
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]                     88   1e-17
gi|109150407 kelch-like 6 [Homo sapiens]                               84   2e-16
gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Hom...    80   2e-15
gi|38194229 kelch-like 17 [Homo sapiens]                               80   4e-15
gi|151108413 BTB (POZ) domain containing 9 isoform a [Homo sapiens]    78   1e-14
gi|151108411 BTB (POZ) domain containing 9 isoform a [Homo sapiens]    78   1e-14
gi|55925608 kelch-like 21 [Homo sapiens]                               77   3e-14
gi|166235129 kelch-like 3 [Homo sapiens]                               76   4e-14
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]             74   3e-13
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]             74   3e-13
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]                74   3e-13
gi|209571547 kelch repeat and BTB (POZ) domain containing 4 isof...    73   4e-13
gi|209693446 kelch repeat and BTB (POZ) domain containing 4 isof...    73   4e-13
gi|8922528 kelch-like 11 [Homo sapiens]                                72   6e-13
gi|40018614 DRE1 protein [Homo sapiens]                                72   1e-12
gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens]       71   1e-12
gi|156616301 kelch-like 32 [Homo sapiens]                              70   3e-12
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo...    69   5e-12
gi|45593142 kelch repeat and BTB (POZ) domain containing 5 [Homo...    69   7e-12
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]         68   1e-11
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]         68   1e-11
gi|40255071 kelch-like 23 [Homo sapiens]                               68   1e-11

>gi|56117834 speckle-type POZ protein [Homo sapiens]
          Length = 374

 Score =  758 bits (1958), Expect = 0.0
 Identities = 374/374 (100%), Positives = 374/374 (100%)

Query: 1   MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG 60
           MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG
Sbjct: 1   MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG 60

Query: 61  ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ 120
           ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ
Sbjct: 61  ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ 120

Query: 121 RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK 180
           RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK
Sbjct: 121 RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK 180

Query: 181 VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR 240
           VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR
Sbjct: 181 VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR 240

Query: 241 VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE 300
           VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE
Sbjct: 241 VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE 300

Query: 301 NAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQ 360
           NAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQ
Sbjct: 301 NAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQ 360

Query: 361 CPFLGPPRKRLKQS 374
           CPFLGPPRKRLKQS
Sbjct: 361 CPFLGPPRKRLKQS 374


>gi|56117832 speckle-type POZ protein [Homo sapiens]
          Length = 374

 Score =  758 bits (1958), Expect = 0.0
 Identities = 374/374 (100%), Positives = 374/374 (100%)

Query: 1   MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG 60
           MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG
Sbjct: 1   MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG 60

Query: 61  ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ 120
           ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ
Sbjct: 61  ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ 120

Query: 121 RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK 180
           RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK
Sbjct: 121 RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK 180

Query: 181 VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR 240
           VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR
Sbjct: 181 VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR 240

Query: 241 VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE 300
           VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE
Sbjct: 241 VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE 300

Query: 301 NAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQ 360
           NAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQ
Sbjct: 301 NAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQ 360

Query: 361 CPFLGPPRKRLKQS 374
           CPFLGPPRKRLKQS
Sbjct: 361 CPFLGPPRKRLKQS 374


>gi|56117830 speckle-type POZ protein [Homo sapiens]
          Length = 374

 Score =  758 bits (1958), Expect = 0.0
 Identities = 374/374 (100%), Positives = 374/374 (100%)

Query: 1   MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG 60
           MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG
Sbjct: 1   MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG 60

Query: 61  ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ 120
           ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ
Sbjct: 61  ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ 120

Query: 121 RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK 180
           RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK
Sbjct: 121 RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK 180

Query: 181 VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR 240
           VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR
Sbjct: 181 VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR 240

Query: 241 VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE 300
           VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE
Sbjct: 241 VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE 300

Query: 301 NAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQ 360
           NAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQ
Sbjct: 301 NAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQ 360

Query: 361 CPFLGPPRKRLKQS 374
           CPFLGPPRKRLKQS
Sbjct: 361 CPFLGPPRKRLKQS 374


>gi|56117828 speckle-type POZ protein [Homo sapiens]
          Length = 374

 Score =  758 bits (1958), Expect = 0.0
 Identities = 374/374 (100%), Positives = 374/374 (100%)

Query: 1   MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG 60
           MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG
Sbjct: 1   MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG 60

Query: 61  ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ 120
           ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ
Sbjct: 61  ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ 120

Query: 121 RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK 180
           RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK
Sbjct: 121 RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK 180

Query: 181 VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR 240
           VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR
Sbjct: 181 VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR 240

Query: 241 VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE 300
           VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE
Sbjct: 241 VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE 300

Query: 301 NAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQ 360
           NAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQ
Sbjct: 301 NAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQ 360

Query: 361 CPFLGPPRKRLKQS 374
           CPFLGPPRKRLKQS
Sbjct: 361 CPFLGPPRKRLKQS 374


>gi|4507183 speckle-type POZ protein [Homo sapiens]
          Length = 374

 Score =  758 bits (1958), Expect = 0.0
 Identities = 374/374 (100%), Positives = 374/374 (100%)

Query: 1   MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG 60
           MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG
Sbjct: 1   MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG 60

Query: 61  ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ 120
           ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ
Sbjct: 61  ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ 120

Query: 121 RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK 180
           RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK
Sbjct: 121 RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK 180

Query: 181 VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR 240
           VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR
Sbjct: 181 VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR 240

Query: 241 VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE 300
           VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE
Sbjct: 241 VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE 300

Query: 301 NAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQ 360
           NAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQ
Sbjct: 301 NAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQ 360

Query: 361 CPFLGPPRKRLKQS 374
           CPFLGPPRKRLKQS
Sbjct: 361 CPFLGPPRKRLKQS 374


>gi|56117836 speckle-type POZ protein [Homo sapiens]
          Length = 374

 Score =  758 bits (1958), Expect = 0.0
 Identities = 374/374 (100%), Positives = 374/374 (100%)

Query: 1   MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG 60
           MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG
Sbjct: 1   MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG 60

Query: 61  ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ 120
           ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ
Sbjct: 61  ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ 120

Query: 121 RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK 180
           RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK
Sbjct: 121 RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK 180

Query: 181 VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR 240
           VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR
Sbjct: 181 VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR 240

Query: 241 VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE 300
           VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE
Sbjct: 241 VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE 300

Query: 301 NAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQ 360
           NAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQ
Sbjct: 301 NAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQ 360

Query: 361 CPFLGPPRKRLKQS 374
           CPFLGPPRKRLKQS
Sbjct: 361 CPFLGPPRKRLKQS 374


>gi|48717263 speckle-type POZ protein-like [Homo sapiens]
          Length = 392

 Score =  647 bits (1670), Expect = 0.0
 Identities = 316/392 (80%), Positives = 349/392 (89%), Gaps = 18/392 (4%)

Query: 1   MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSG 60
           MSR P+PP P +MS+GP+AESWCYTQ+KVVKFSYMWTINNFSFCREEMGEV+KSSTFSSG
Sbjct: 1   MSREPTPPLPGDMSTGPIAESWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSSG 60

Query: 61  ANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQ 120
            +DK+KWCLRVNPKGLD+ESKDYLSLYLLLVSCPKSEVRAKFKFS+LNAK EETKAMESQ
Sbjct: 61  PSDKMKWCLRVNPKGLDDESKDYLSLYLLLVSCPKSEVRAKFKFSLLNAKREETKAMESQ 120

Query: 121 RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVK 180
           RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISG    N +K
Sbjct: 121 RAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGHTNTNTLK 180

Query: 181 VPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR 240
           VPECRLA++LG LWEN+RFTDC   V GQEF+AHK++LAARSPVF+AMFEHEMEESKKNR
Sbjct: 181 VPECRLAEDLGNLWENTRFTDCSFFVRGQEFKAHKSVLAARSPVFNAMFEHEMEESKKNR 240

Query: 241 VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVE 300
           VEIND++PEVFKEMM FIYTG+APNLDKMAD+LLAAADKYALERLKVMCE+ALCSNLSVE
Sbjct: 241 VEINDLDPEVFKEMMRFIYTGRAPNLDKMADNLLAAADKYALERLKVMCEEALCSNLSVE 300

Query: 301 NAAEILILADLHSADQLKTQAVDFIN------------------YHASDVLETSGWKSMV 342
           N A+ L+LADLHSA+QLK QA+DFIN                    A+D++ETSGWKSM+
Sbjct: 301 NVADTLVLADLHSAEQLKAQAIDFINRCSVLRQLGCKDGKNWNSNQATDIMETSGWKSMI 360

Query: 343 VSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS 374
            SHPHLVAEA+R+LASAQCP  G PRKRLKQS
Sbjct: 361 QSHPHLVAEAFRALASAQCPQFGIPRKRLKQS 392


>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
          Length = 586

 Score = 89.4 bits (220), Expect = 5e-18
 Identities = 53/157 (33%), Positives = 80/157 (50%), Gaps = 4/157 (2%)

Query: 183 ECRLADELGGLWENSR----FTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKK 238
           E +L     G+  N R      D  L V  ++  AH+ +LAA S  F+ MF   M ESK 
Sbjct: 23  EAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKS 82

Query: 239 NRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLS 298
             VE+ D EP++ ++++ F YT +          LL AA++Y +E +K MC D L   + 
Sbjct: 83  FEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVD 142

Query: 299 VENAAEILILADLHSADQLKTQAVDFINYHASDVLET 335
             N   I +LA+     +LK  A DFI+ H ++V +T
Sbjct: 143 ASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKT 179


>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
          Length = 564

 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 48/135 (35%), Positives = 73/135 (54%)

Query: 201 DCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYT 260
           D  L V  ++  AH+ +LAA S  F+ MF   M ESK   VE+ D EP++ ++++ F YT
Sbjct: 23  DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYT 82

Query: 261 GKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQ 320
            +          LL AA++Y +E +K MC D L   +   N   I +LA+     +LK  
Sbjct: 83  ARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKAT 142

Query: 321 AVDFINYHASDVLET 335
           A DFI+ H ++V +T
Sbjct: 143 ADDFIHQHFTEVYKT 157


>gi|109150407 kelch-like 6 [Homo sapiens]
          Length = 621

 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 53/167 (31%), Positives = 82/167 (49%)

Query: 186 LADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEIND 245
           L + L  L   +  TD  LCV  QEF  H+ +LAA S  F AMF ++++E  + R+ I  
Sbjct: 58  LQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKG 117

Query: 246 VEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEI 305
           V+ E    ++ + YT KA    +    +L AA+ +   R+   C   L   L+ EN   I
Sbjct: 118 VDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGI 177

Query: 306 LILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEA 352
           L LAD HS D LK Q   +I  +   +L +  +  + V   H + ++
Sbjct: 178 LRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKS 224


>gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Homo
           sapiens]
          Length = 623

 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 49/164 (29%), Positives = 77/164 (46%), Gaps = 2/164 (1%)

Query: 186 LADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEIND 245
           L ++L   +E   FTD  L V G EF  HK +LA  S  F AMF   + ESK+  V + +
Sbjct: 17  LLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRN 76

Query: 246 VEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEI 305
           V+    + ++ + YTG     D   + L   A    +E +   C + L   ++ EN   +
Sbjct: 77  VDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRL 136

Query: 306 LILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLV 349
           L  ADL S ++LK  A   + +  + V     +  M +SH  L+
Sbjct: 137 LSFADLFSCEELKQSAKRMVEHKFTAVYHQDAF--MQLSHDLLI 178


>gi|38194229 kelch-like 17 [Homo sapiens]
          Length = 642

 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 47/135 (34%), Positives = 69/135 (51%)

Query: 201 DCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYT 260
           D  L VA +E +AHK +LA+ SP F AMF +EM ES++  V ++D++P+   +++ F YT
Sbjct: 93  DIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYT 152

Query: 261 GKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQ 320
            +    +     LL AA    L  ++  C   L S L   N   I   AD HS   L   
Sbjct: 153 AEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADAHSCSDLLKA 212

Query: 321 AVDFINYHASDVLET 335
           A  ++  H  DV +T
Sbjct: 213 AHRYVLQHFVDVAKT 227


>gi|151108413 BTB (POZ) domain containing 9 isoform a [Homo sapiens]
          Length = 612

 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 47/160 (29%), Positives = 80/160 (50%), Gaps = 4/160 (2%)

Query: 186 LADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKN-RVEIN 244
           L++ +G L     + D    V  + F AH+ ILAAR   F A+    M ES+    + + 
Sbjct: 22  LSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQ 81

Query: 245 DVEPEVFKEMMCFIYTGKAPNLDKMAD---DLLAAADKYALERLKVMCEDALCSNLSVEN 301
           D   E F  ++ +IYTG+A   D+  +   D L+ A KY    L+    + LC+ L+++N
Sbjct: 82  DTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQN 141

Query: 302 AAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSM 341
                 +A L+S  +L      F++ +A +VL + G+ S+
Sbjct: 142 VCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSL 181


>gi|151108411 BTB (POZ) domain containing 9 isoform a [Homo sapiens]
          Length = 612

 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 47/160 (29%), Positives = 80/160 (50%), Gaps = 4/160 (2%)

Query: 186 LADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKN-RVEIN 244
           L++ +G L     + D    V  + F AH+ ILAAR   F A+    M ES+    + + 
Sbjct: 22  LSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQ 81

Query: 245 DVEPEVFKEMMCFIYTGKAPNLDKMAD---DLLAAADKYALERLKVMCEDALCSNLSVEN 301
           D   E F  ++ +IYTG+A   D+  +   D L+ A KY    L+    + LC+ L+++N
Sbjct: 82  DTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQN 141

Query: 302 AAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSM 341
                 +A L+S  +L      F++ +A +VL + G+ S+
Sbjct: 142 VCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSL 181


>gi|55925608 kelch-like 21 [Homo sapiens]
          Length = 597

 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 48/144 (33%), Positives = 73/144 (50%), Gaps = 1/144 (0%)

Query: 190 LGGLWENSRFTDCCLCVAG-QEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEP 248
           L  L    +F D  L  AG ++F AH+A+LAA SP F AMF  ++ ES+  RV ++ V P
Sbjct: 25  LSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPP 84

Query: 249 EVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILIL 308
           ++ + ++ F YTG+       A+ LL AAD      +K  C   L   L + N  ++   
Sbjct: 85  DMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDF 144

Query: 309 ADLHSADQLKTQAVDFINYHASDV 332
           A+  S   L + A  FI  H  ++
Sbjct: 145 AEAFSCSGLASAAQRFILRHVGEL 168


>gi|166235129 kelch-like 3 [Homo sapiens]
          Length = 587

 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 44/133 (33%), Positives = 67/133 (50%)

Query: 201 DCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYT 260
           D  +     E +AH+ +LAA SP F AMF  +M ESK  ++EI DV+ +   +++ +IYT
Sbjct: 51  DVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYT 110

Query: 261 GKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQ 320
            +    ++    LL AA    L  ++  C D L S L   N   I   AD+H+   L  Q
Sbjct: 111 AEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQ 170

Query: 321 AVDFINYHASDVL 333
           A  +   H  +V+
Sbjct: 171 ANAYAEQHFPEVM 183


>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
          Length = 597

 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 43/133 (32%), Positives = 66/133 (49%)

Query: 201 DCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYT 260
           D  +     E  AH+ +LAA SP F AMF  EM ES+  RV I +V+    + ++ ++YT
Sbjct: 61  DVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYT 120

Query: 261 GKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQ 320
            +    ++    LL AA    L+ +K  C + L S L   N   I   AD+H+   L  +
Sbjct: 121 AEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNK 180

Query: 321 AVDFINYHASDVL 333
           A  +   H +DV+
Sbjct: 181 ANTYAEQHFADVV 193


>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
          Length = 593

 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 43/133 (32%), Positives = 66/133 (49%)

Query: 201 DCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYT 260
           D  +     E  AH+ +LAA SP F AMF  EM ES+  RV I +V+    + ++ ++YT
Sbjct: 57  DVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYT 116

Query: 261 GKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQ 320
            +    ++    LL AA    L+ +K  C + L S L   N   I   AD+H+   L  +
Sbjct: 117 AEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNK 176

Query: 321 AVDFINYHASDVL 333
           A  +   H +DV+
Sbjct: 177 ANTYAEQHFADVV 189


>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
          Length = 589

 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 53/187 (28%), Positives = 88/187 (47%), Gaps = 7/187 (3%)

Query: 161 VSVVQDSVNISGQNTMNMVKV-----PECRLADELGGLWENSRFTDCCLCVAGQEFQAHK 215
           VSV +   + S   +MN+        P+C LA  L  L ++  FTD  L    + F  H+
Sbjct: 3   VSVHETRKSRSSTGSMNVTLFHKASHPDCVLA-HLNTLRKHCMFTDVTLWAGDRAFPCHR 61

Query: 216 AILAARSPVFSAMFEHEMEESKKNRVEIND-VEPEVFKEMMCFIYTGKAPNLDKMADDLL 274
           A+LAA S  F AMF H + ES+ + V   D + PEV + ++ F Y+ +    ++ A+ LL
Sbjct: 62  AVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLL 121

Query: 275 AAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLE 334
            A D      ++    + L  NL   N   +++L+D H   +L   +      H   V +
Sbjct: 122 EAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQ 181

Query: 335 TSGWKSM 341
           +  + S+
Sbjct: 182 SEDFNSL 188


>gi|209571547 kelch repeat and BTB (POZ) domain containing 4 isoform
           a [Homo sapiens]
          Length = 534

 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 41/141 (29%), Positives = 68/141 (48%)

Query: 195 ENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEM 254
           E   F D  + V G+EFQ H+ +L+A+S  F +MF   ++E+    + + DV   VF+ +
Sbjct: 56  EEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQLL 115

Query: 255 MCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSA 314
           + +IY G      +   ++   +D Y L  L   C   L   + V N  +++ LAD HS 
Sbjct: 116 VDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSD 175

Query: 315 DQLKTQAVDFINYHASDVLET 335
            +L T A      H + +  T
Sbjct: 176 PELYTAAKHCAKTHLAQLQNT 196


>gi|209693446 kelch repeat and BTB (POZ) domain containing 4 isoform
           b [Homo sapiens]
          Length = 518

 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 41/141 (29%), Positives = 68/141 (48%)

Query: 195 ENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEM 254
           E   F D  + V G+EFQ H+ +L+A+S  F +MF   ++E+    + + DV   VF+ +
Sbjct: 40  EEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQLL 99

Query: 255 MCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSA 314
           + +IY G      +   ++   +D Y L  L   C   L   + V N  +++ LAD HS 
Sbjct: 100 VDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSD 159

Query: 315 DQLKTQAVDFINYHASDVLET 335
            +L T A      H + +  T
Sbjct: 160 PELYTAAKHCAKTHLAQLQNT 180


>gi|8922528 kelch-like 11 [Homo sapiens]
          Length = 708

 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 44/141 (31%), Positives = 73/141 (51%), Gaps = 11/141 (7%)

Query: 199 FTDCCLC---VAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEIND------VEPE 249
           F D  LC     G+EF+AH+++LAA +  F+ +   +  ES+  RVE+         EP+
Sbjct: 93  FCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPGPEPD 152

Query: 250 VFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILA 309
             + ++ ++YTG+         ++L  AD++ L RLK  C + L   L + N   I  LA
Sbjct: 153 TVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLA 212

Query: 310 DLHSADQLKTQAVDFI--NYH 328
            +++  QL  +A D I  N+H
Sbjct: 213 HMYTLSQLALKAADMIRRNFH 233


>gi|40018614 DRE1 protein [Homo sapiens]
          Length = 600

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 44/134 (32%), Positives = 65/134 (48%)

Query: 199 FTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFI 258
           FTD  +CV G+EF  H+A+L+A S  F AMF ++  ES++  VEIN +  E  +  + ++
Sbjct: 65  FTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYV 124

Query: 259 YTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLK 318
           YTGK     +    L   +  + +  L+  C   L   L   N   I   AD HS   L 
Sbjct: 125 YTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLF 184

Query: 319 TQAVDFINYHASDV 332
           T+  +F      DV
Sbjct: 185 TKCKNFALQTFEDV 198


>gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens]
          Length = 1353

 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 54/201 (26%), Positives = 95/201 (47%), Gaps = 18/201 (8%)

Query: 166 DSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCL-CVAGQEFQAHKAILAARSPV 224
           + +N+  +NT N +K+ + +           S   D  +  V G+EF  HK +L AR   
Sbjct: 744 EKINVIAKNTGNKLKLSQKKC----------SFLCDVTMKSVDGKEFPCHKCVLCARLEY 793

Query: 225 FSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKA------PNLDKMADDLLAAAD 278
           F +M      E+         +  ++ K ++ ++YT +A       N+D +   +L  AD
Sbjct: 794 FHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICS-VLVVAD 852

Query: 279 KYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLETSGW 338
           +  + RLK +CE AL   L+++NAA +L  A ++SA QLK   + FI  + + +LE    
Sbjct: 853 QLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSL 912

Query: 339 KSMVVSHPHLVAEAYRSLASA 359
             +       ++E YR +  A
Sbjct: 913 DVLSDGVLKDLSEFYRKMIPA 933



 Score = 30.4 bits (67), Expect = 2.7
 Identities = 25/89 (28%), Positives = 37/89 (41%), Gaps = 19/89 (21%)

Query: 185 RLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEIN 244
           R ADE+  +       D    V  + F AHK ILA  S  F  +F  +   S+   +   
Sbjct: 555 READEMDSIH------DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQK 608

Query: 245 D-------------VEPEVFKEMMCFIYT 260
           D             V P++F+ ++ FIYT
Sbjct: 609 DEDSAGCHLFVVEKVHPDMFEYLLQFIYT 637


>gi|156616301 kelch-like 32 [Homo sapiens]
          Length = 620

 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 46/135 (34%), Positives = 68/135 (50%)

Query: 201 DCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYT 260
           D  L    Q+F AHKA+LAA S  F AMF   M ES  + V ++ V     K+ + F YT
Sbjct: 43  DITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADEVNLHGVTSLGLKQALEFAYT 102

Query: 261 GKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQ 320
           G+      +  D+LAA     L  L  +C   L   L+  N  ++  LADL +   L+  
Sbjct: 103 GQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKA 162

Query: 321 AVDFINYHASDVLET 335
            +DF+  H S++L++
Sbjct: 163 VIDFLVKHLSELLKS 177


>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
           sapiens]
          Length = 589

 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 46/162 (28%), Positives = 80/162 (49%), Gaps = 5/162 (3%)

Query: 161 VSVVQDSVNISGQNTMNMVKVPECRLADE----LGGLWENSRFTDCCLCVAGQEFQAHKA 216
           VSV ++  + +   ++N+    +   AD     L  L +   FTD  L    + F  H+A
Sbjct: 3   VSVHENRKSRASSGSINIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRA 62

Query: 217 ILAARSPVFSAMFEHEMEESKKNRVEI-NDVEPEVFKEMMCFIYTGKAPNLDKMADDLLA 275
           +LAA S  F AMF   ++ES+ + V   N + PEV + ++ + Y+ +    ++ A+ LL 
Sbjct: 63  VLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLE 122

Query: 276 AADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQL 317
           A D    + ++  C + L  NL   N   +L+L+D H   +L
Sbjct: 123 AGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKL 164


>gi|45593142 kelch repeat and BTB (POZ) domain containing 5 [Homo
           sapiens]
          Length = 621

 Score = 68.9 bits (167), Expect = 7e-12
 Identities = 41/143 (28%), Positives = 69/143 (48%), Gaps = 2/143 (1%)

Query: 186 LADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEIND 245
           L D L  + ++ +F DC +    +EF  H+ +LAA SP F A F  E E +    + + +
Sbjct: 19  LQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERA--GELHLEE 76

Query: 246 VEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEI 305
           V P+V  +++ ++YT +    +    DL AAA ++ +  +  +C   L   L + N   +
Sbjct: 77  VSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAV 136

Query: 306 LILADLHSADQLKTQAVDFINYH 328
             L  L    +L   A DFI  H
Sbjct: 137 FRLGLLLDCARLAVAARDFICAH 159


>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
          Length = 624

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 48/179 (26%), Positives = 81/179 (45%), Gaps = 6/179 (3%)

Query: 183 ECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVE 242
           E RL+ +L  +    ++ D        +F AHK +LA+ SPVF AMF + + E     V 
Sbjct: 69  ELRLSQQLCDVTLQVKYQDA----PAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVS 124

Query: 243 INDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENA 302
           I  + P+V + ++ F YT      +K    ++  A  Y ++ +   C D L   L   NA
Sbjct: 125 IEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNA 184

Query: 303 AEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQC 361
             I   A+     +L  +A ++I  H  +V +   + ++  SH  LV    R   + +C
Sbjct: 185 IGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNL--SHCQLVTLISRDDLNVRC 241


>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
          Length = 624

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 48/179 (26%), Positives = 81/179 (45%), Gaps = 6/179 (3%)

Query: 183 ECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVE 242
           E RL+ +L  +    ++ D        +F AHK +LA+ SPVF AMF + + E     V 
Sbjct: 69  ELRLSQQLCDVTLQVKYQDA----PAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVS 124

Query: 243 INDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENA 302
           I  + P+V + ++ F YT      +K    ++  A  Y ++ +   C D L   L   NA
Sbjct: 125 IEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNA 184

Query: 303 AEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQC 361
             I   A+     +L  +A ++I  H  +V +   + ++  SH  LV    R   + +C
Sbjct: 185 IGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNL--SHCQLVTLISRDDLNVRC 241


>gi|40255071 kelch-like 23 [Homo sapiens]
          Length = 558

 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 37/124 (29%), Positives = 66/124 (53%), Gaps = 1/124 (0%)

Query: 199 FTDCCL-CVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCF 257
           FTD  L C +G  F  H+A+LAA S  F AMF  +M+E  KN+++++ +  ++ + ++ +
Sbjct: 35  FTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNY 94

Query: 258 IYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQL 317
            YT +     +    LL AAD      +K  CE  L  +L ++N   +   A+ H   +L
Sbjct: 95  AYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHLDIDNCIGMHSFAEFHVCPEL 154

Query: 318 KTQA 321
           + ++
Sbjct: 155 EKES 158


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.132    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,995,573
Number of Sequences: 37866
Number of extensions: 565006
Number of successful extensions: 2015
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 140
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 1779
Number of HSP's gapped (non-prelim): 202
length of query: 374
length of database: 18,247,518
effective HSP length: 104
effective length of query: 270
effective length of database: 14,309,454
effective search space: 3863552580
effective search space used: 3863552580
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press