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Search of human proteins with 55749726
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55749726 kelch domain containing 5 [Homo sapiens]
(505 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55749726 kelch domain containing 5 [Homo sapiens] 1026 0.0
gi|7662260 kelch repeat and BTB (POZ) domain containing 11 [Homo... 125 7e-29
gi|157384932 hypothetical protein LOC390594 [Homo sapiens] 125 7e-29
gi|206597556 kelch domain containing 7B [Homo sapiens] 125 1e-28
gi|116089333 kelch domain containing 7A [Homo sapiens] 111 2e-24
gi|11056006 kelch-like 12 [Homo sapiens] 108 9e-24
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 105 1e-22
gi|45643138 kelch-like 13 [Homo sapiens] 105 1e-22
gi|24308181 kelch-like 9 [Homo sapiens] 105 1e-22
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 103 5e-22
gi|223890235 intracisternal A particle-promoted polypeptide isof... 103 5e-22
gi|55741643 kelch-like 14 [Homo sapiens] 100 3e-21
gi|8922854 kelch-like 26 [Homo sapiens] 100 5e-21
gi|227497736 T-cell activation kelch repeat protein [Homo sapiens] 96 8e-20
gi|31542246 kelch-like 36 [Homo sapiens] 96 1e-19
gi|166235129 kelch-like 3 [Homo sapiens] 94 3e-19
gi|40018614 DRE1 protein [Homo sapiens] 94 4e-19
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 92 1e-18
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 92 1e-18
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 91 3e-18
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 91 3e-18
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 91 3e-18
gi|88196794 kelch-like 35 [Homo sapiens] 91 3e-18
gi|109150407 kelch-like 6 [Homo sapiens] 89 9e-18
gi|24475847 influenza virus NS1A binding protein [Homo sapiens] 88 2e-17
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 88 2e-17
gi|14780904 kelch-like 1 protein [Homo sapiens] 87 3e-17
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 87 3e-17
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 87 3e-17
gi|55925604 kelch-like 18 [Homo sapiens] 84 2e-16
>gi|55749726 kelch domain containing 5 [Homo sapiens]
Length = 505
Score = 1026 bits (2652), Expect = 0.0
Identities = 505/505 (100%), Positives = 505/505 (100%)
Query: 1 MSAEEMVQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAP 60
MSAEEMVQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAP
Sbjct: 1 MSAEEMVQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAP 60
Query: 61 GLRLVLDFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQL 120
GLRLVLDFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQL
Sbjct: 61 GLRLVLDFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQL 120
Query: 121 LLSQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVS 180
LLSQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVS
Sbjct: 121 LLSQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVS 180
Query: 181 LKQRLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDL 240
LKQRLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDL
Sbjct: 181 LKQRLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDL 240
Query: 241 VNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVN 300
VNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVN
Sbjct: 241 VNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVN 300
Query: 301 SKLYAIGGQAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMN 360
SKLYAIGGQAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMN
Sbjct: 301 SKLYAIGGQAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMN 360
Query: 361 ILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQS 420
ILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQS
Sbjct: 361 ILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQS 420
Query: 421 YNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVTLSTSLEHRVFLKYNIFSDSWE 480
YNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVTLSTSLEHRVFLKYNIFSDSWE
Sbjct: 421 YNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVTLSTSLEHRVFLKYNIFSDSWE 480
Query: 481 AFRRFPAFGHNLLVSSLYLPNKAET 505
AFRRFPAFGHNLLVSSLYLPNKAET
Sbjct: 481 AFRRFPAFGHNLLVSSLYLPNKAET 505
>gi|7662260 kelch repeat and BTB (POZ) domain containing 11 [Homo
sapiens]
Length = 623
Score = 125 bits (315), Expect = 7e-29
Identities = 130/460 (28%), Positives = 196/460 (42%), Gaps = 70/460 (15%)
Query: 20 KRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVLDFINAGGAREGWL 79
K L +SDYFRA +V +++G+S LRL+L A G +
Sbjct: 155 KAVLAARSDYFRA-------------RASRDVLRVQGVSLTALRLLL-----ADAYSGRM 196
Query: 80 LGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQLLLS----QVRLNNCLEMYR 135
G R + ++E+V A LQ+ Q Q+ L NC E+
Sbjct: 197 AGVRPDN---------------VAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLS 241
Query: 136 LAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVSLKQRLREARM-TGTP 194
A+ L +L++A FM H+ EVL +P + G A D+ L++RLR R
Sbjct: 242 AAKRQRLNELRDAAYCFMSDHYLEVLREPA--VFGRLSGAERDLLLRRRLRAGRAHLLAA 299
Query: 195 VLVALGDFLGG----PLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLVNVRGYGSAI 250
L G+ G P +G+ ++ + W L P+ RG G +
Sbjct: 300 ALGPAGERAGSRPQSPSGDADARGDA-AVYCFHAAAGEWRELTRL--PEGAPARGCGLCV 356
Query: 251 LDNYLFIVGGYRITSQEISAAHS-----YNPSTNEWLQVASMNQKRSNFKLVAVNSKLYA 305
L NYLF+ GG + A S YNP+T+ W V + Q RS +L+A++ LYA
Sbjct: 357 LYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYA 416
Query: 306 IGGQAVSNVECYNPEQDAWNFVAPLPNP--LAEFSACECKGKIYVIGGYTTRDRNMNILQ 363
+GG+ + +VE Y+P D W VAPLP A C G+IYV GG +L+
Sbjct: 417 VGGECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG----SLFYRLLK 472
Query: 364 YCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQS--EDMLTVQSY 421
Y P D W R MV+++ IY +L +R +Q+ ++V Y
Sbjct: 473 YDPRRDEWQECPCSSSRERSADMVALDGFIY-----RFDLSGSRGEAQAAGPSGVSVSRY 527
Query: 422 NTVTRQW----LYLKENTSKSGLN-LTCALHNDGIYIMSR 456
+ + +QW L+ +GL CA + IY +SR
Sbjct: 528 HCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCVSR 567
>gi|157384932 hypothetical protein LOC390594 [Homo sapiens]
Length = 458
Score = 125 bits (315), Expect = 7e-29
Identities = 125/475 (26%), Positives = 203/475 (42%), Gaps = 76/475 (16%)
Query: 4 EEMVQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLR 63
+ +VQ+ + + + + L+E +FR L+RSGMRE + E +L LSA G R
Sbjct: 6 QTLVQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEV------RLGVLSAGGFR 59
Query: 64 LVLDFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQLLLS 123
L + RG++ EDE L + VE A+FLQ +L + L
Sbjct: 60 ATLQVL-------------RGDRPALAAEDE-------LLQAVECAAFLQAPALARFLEH 99
Query: 124 QVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVSLKQ 183
+ +NC + A +GL D+ + F+ E+ + L P +L+
Sbjct: 100 NLTSDNCALLCDAAAAFGLRDVFHSAALFICDGERELAAE-----LALPEARAYVAALRP 154
Query: 184 RLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLVNV 243
A T TP AP + ++ +E + W LA LP + +
Sbjct: 155 SSYAAVSTHTP-------------APGFLEDASRTLCYLDEEEDAWRTLAA-LPLEASTL 200
Query: 244 RGYGSAILDNYLFIVGGYRITSQEI-SAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSK 302
G A L N L+IVGG R S+E+ Y+P W + S +Q R + L + +
Sbjct: 201 LA-GVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGR 259
Query: 303 LYAIGGQ----AVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRN 358
LYAIGG+ +S+VE Y+P W+FVA LP P A + G+++V + D
Sbjct: 260 LYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVC-LWRPADTT 318
Query: 359 MNILQYCPSSDMWTLFETCDVHIRKQQ-----MVSVEETIYIVGGCLHELGPNRRSSQSE 413
+++Y +D W +R+ Q MV+ +++Y+V R+ S+
Sbjct: 319 A-VVEYAVRTDAWLPV----AELRRPQSYGHCMVAHRDSLYVV-----------RNGPSD 362
Query: 414 DML--TVQSYNTVTRQWLYLK-ENTSKSGLNLTCALHNDGIYIMSRDVTLSTSLE 465
D L + N T QW L + + G T + D +Y ++R TL ++E
Sbjct: 363 DFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIE 417
>gi|206597556 kelch domain containing 7B [Homo sapiens]
Length = 594
Score = 125 bits (313), Expect = 1e-28
Identities = 107/356 (30%), Positives = 152/356 (42%), Gaps = 37/356 (10%)
Query: 121 LLSQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVS 180
L ++ L +CL++ AQ +G P L + M + VL P + S +S
Sbjct: 214 LRRRLDLGSCLDVLAFAQQHGEPGLAQETYALMSDNLLRVLGDPCLYRRLSAADRERILS 273
Query: 181 LKQRLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLR-----------YEEMTERW 229
L+ R + G VL +L L P EPP+ + W
Sbjct: 274 LRTG-RGRAVLGVLVLPSLYQGGRSGLPRGPRGEEPPAAAPVSLPLPAHLHVFNPRENTW 332
Query: 230 FPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHS---YNPSTNEWLQVAS 286
PL P+ +RG G + NYLF+ GG R + + ++ YNP TN W QV
Sbjct: 333 RPLTQ--VPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNIWSQVRP 390
Query: 287 MNQKRSNFKLVAVNSKLYAIGGQAVSNVECYNPEQDAWNFVAPLPN---PLAEFSACECK 343
M Q R+ KLVA++ LYAIGG+ + ++ECY+P DAW APLP P+A A C+
Sbjct: 391 MQQARAQLKLVALDGLLYAIGGECLYSMECYDPRTDAWTPRAPLPAGTFPVAH-EAVACR 449
Query: 344 GKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHEL 403
G IYV GG+ +L+Y P D W H R +V+ +GG L+
Sbjct: 450 GDIYVTGGHLF----YRLLRYSPVKDAWDECPYSASHRRSSDIVA-------LGGFLYRF 498
Query: 404 GPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVT 459
R + V YNTVT W + L C + IY ++ VT
Sbjct: 499 DLLRGVGAA-----VMRYNTVTGSWSRAASLPLPAPAPLHCTTLGNTIYCLNPQVT 549
>gi|116089333 kelch domain containing 7A [Homo sapiens]
Length = 777
Score = 111 bits (277), Expect = 2e-24
Identities = 115/386 (29%), Positives = 170/386 (44%), Gaps = 53/386 (13%)
Query: 124 QVRLN--NCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVSL 181
QVRL+ NC E+ LA+ L L+EA + M ++ +VL P + G A ++ L
Sbjct: 427 QVRLDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQVLRSPDIY--GCLSGAERELIL 484
Query: 182 KQRLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLV 241
++RLR G LV + P G + Y++ + W PLA +PP+ V
Sbjct: 485 QRRLR-----GRQYLVV------ADVCPKEDSG---GLCCYDDEQDVWRPLAR-MPPEAV 529
Query: 242 NVRGYGSAILDNYLFIVGGYRITS-QEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVN 300
+ RG L NYLF+V G + Q S YNP T W +V +NQ R + +LVA++
Sbjct: 530 S-RGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALD 588
Query: 301 SKLYAIGGQAVSNVECYNPEQDAWNFVAPLPN---PLAEFSACECKGKIYVIGGYTTRDR 357
LYAIGG+ +++VE Y+P D W+F PLP+ LA + K +I+V GG
Sbjct: 589 GHLYAIGGECLNSVERYDPRLDRWDFAPPLPSDTFALAHTATVRAK-EIFVTGG----SL 643
Query: 358 NMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLT 417
+ ++ W T R +MV+ V G L+ NR +
Sbjct: 644 RFLLFRFSAQEQRWWAGPTGGSKDRTAEMVA-------VNGFLYRFDLNRSLG-----IA 691
Query: 418 VQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVT---LSTSLEHRVFLKYNI 474
V + TR W + CA+ ++ IY + R T L+ S+ R K
Sbjct: 692 VYRCSASTRLWYECATYRTPYPDAFQCAVVDNLIYCVGRRSTLCFLADSVSPRFVPK--- 748
Query: 475 FSDSWEAFRRFPAFGHNLLVSSLYLP 500
R FPA LL + L LP
Sbjct: 749 ------ELRSFPAPQGTLLPTVLTLP 768
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 108 bits (271), Expect = 9e-24
Identities = 133/516 (25%), Positives = 210/516 (40%), Gaps = 93/516 (18%)
Query: 7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVL 66
V +R+E + +P + L SDYF A++ S + E G P V ++GL+A + ++L
Sbjct: 35 VTLRVEQKDFPAHRIVLAACSDYFCAMFTSEL-----SEKGKPYVD-IQGLTASTMEILL 88
Query: 67 DFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQ----LLL 122
DF+ V + EL+ AA LQ+ + Q L
Sbjct: 89 DFVYTETVHV---------------------TVENVQELLPAACLLQLKGVKQACCEFLE 127
Query: 123 SQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVSLK 182
SQ+ +NCL + A+ + DL +A F HF EV+ +F LL G+V
Sbjct: 128 SQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQ-----GEVEKL 182
Query: 183 QRLREARMTGT-PVLVALGDFLGGPLAPHPYQGEPPSMLRYEEM---TERW--------- 229
+ E ++ PV A+ +++ A + P++L+Y M T R+
Sbjct: 183 IKCDEIQVDSEEPVFEAVINWVKH--AKKEREESLPNLLQYVRMPLLTPRYITDVIDAEP 240
Query: 230 -----------------FPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAH 272
F L L + R + L +VGG+ I
Sbjct: 241 FIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVE 300
Query: 273 SYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGG----QAVSNVEC--YNPEQD-AWN 325
Y+P T EW + S+ +KR V+++ ++Y IGG +S+VEC Y ++D W
Sbjct: 301 KYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWY 360
Query: 326 FVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQ 385
VAP+ A IYV GG+ R+ ++ +Y P+ D W++
Sbjct: 361 SVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAG 420
Query: 386 MVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKE-NTSKSGLNLTC 444
+V IY +GG G N +S V+ Y+ T W + T +SG +
Sbjct: 421 LVVASGVIYCLGG---YDGLNILNS-------VEKYDPHTGHWTNVTPMATKRSGAGV-- 468
Query: 445 ALHNDGIYIMSR-DVTLSTSLEHRVFLKYNIFSDSW 479
AL ND IY++ D T S YNI +DSW
Sbjct: 469 ALLNDHIYVVGGFDGTAHLSSVE----AYNIRTDSW 500
Score = 73.9 bits (180), Expect = 3e-13
Identities = 46/159 (28%), Positives = 71/159 (44%), Gaps = 11/159 (6%)
Query: 218 SMLRYEEMTERWFPLANNLPPDLVNVR-GYGSAILDNYLFIVGGYRITSQEISAAHSYNP 276
SM RY+ ++W L D+ R G G + ++ +GGY + +++ Y+P
Sbjct: 395 SMERYDPNIDQWSMLG-----DMQTAREGAGLVVASGVIYCLGGYDGLNI-LNSVEKYDP 448
Query: 277 STNEWLQVASMNQKRSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWNFVAPLPN 332
T W V M KRS + +N +Y +GG +S+VE YN D+W V +
Sbjct: 449 HTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTT 508
Query: 333 PLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMW 371
P A +G++Y I GY +I Y P D W
Sbjct: 509 PRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSW 547
Score = 67.8 bits (164), Expect = 2e-11
Identities = 38/132 (28%), Positives = 65/132 (49%), Gaps = 9/132 (6%)
Query: 218 SMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPS 277
S+ +Y+ T W N+ P G G A+L++++++VGG+ T+ +S+ +YN
Sbjct: 442 SVEKYDPHTGHW----TNVTPMATKRSGAGVALLNDHIYVVGGFDGTAH-LSSVEAYNIR 496
Query: 278 TNEWLQVASMNQKRSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWNFVAPLPNP 333
T+ W V SM R + +LYAI G +S++ECY+P D+W V +
Sbjct: 497 TDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQ 556
Query: 334 LAEFSACECKGK 345
+ C + K
Sbjct: 557 RCDAGVCVLREK 568
Score = 56.6 bits (135), Expect = 5e-08
Identities = 31/130 (23%), Positives = 59/130 (45%), Gaps = 5/130 (3%)
Query: 247 GSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAI 306
G+ L + +++ GG+ S+ ++ Y+P+ ++W + M R LV + +Y +
Sbjct: 373 GATTLGDMIYVSGGFD-GSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCL 431
Query: 307 GG----QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNIL 362
GG +++VE Y+P W V P+ + IYV+GG+ ++
Sbjct: 432 GGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVE 491
Query: 363 QYCPSSDMWT 372
Y +D WT
Sbjct: 492 AYNIRTDSWT 501
>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
sapiens]
Length = 634
Score = 105 bits (262), Expect = 1e-22
Identities = 64/212 (30%), Positives = 106/212 (50%), Gaps = 21/212 (9%)
Query: 249 AILDNYLFIVGGYRITSQEISAAHS------YNPSTNEWLQVASMNQKRSNFKLVAVNSK 302
A++D +L++ GG A H+ Y+P N W+ +ASMNQKR++F L N
Sbjct: 361 AVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGL 420
Query: 303 LYAIGGQ----AVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRN 358
+YA GG+ +++++ECY P + W PL ++ G++ V GGY +
Sbjct: 421 VYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAYS 480
Query: 359 MNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTV 418
++ Y P+SD W V++ + +Y++GG +LGP + D+LTV
Sbjct: 481 RSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGG--SQLGPR---GERVDVLTV 535
Query: 419 QSYNTVTRQWLY---LKENTSKSGLNLTCALH 447
+ Y+ T QW Y L+ S +G++ ALH
Sbjct: 536 ECYSPATGQWSYAAPLQVGVSTAGVS---ALH 564
Score = 63.9 bits (154), Expect = 3e-10
Identities = 41/171 (23%), Positives = 77/171 (45%), Gaps = 16/171 (9%)
Query: 213 QGEPPSMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAH 272
+G S+ Y T +W P P V + SA+ D + + GGY + S
Sbjct: 430 EGSLASLECYVPSTNQWQPKT----PLEVARCCHASAVADGRVLVTGGYIANAYSRSVC- 484
Query: 273 SYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQA---------VSNVECYNPEQDA 323
+Y+P+++ W ++ +++ R V ++ ++Y +GG V VECY+P
Sbjct: 485 AYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQ 544
Query: 324 WNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMN--ILQYCPSSDMWT 372
W++ APL ++ G+ Y++GG+ ++ I + P + WT
Sbjct: 545 WSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWT 595
Score = 54.7 bits (130), Expect = 2e-07
Identities = 43/187 (22%), Positives = 72/187 (38%), Gaps = 14/187 (7%)
Query: 221 RYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNE 280
RY+ W LA+ + R + S + N L G R +++ Y PSTN+
Sbjct: 391 RYDPRFNTWIHLAS-----MNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQ 445
Query: 281 WLQVASMNQKRSNFKLVAVNSKLYAIGG---QAVSNVEC-YNPEQDAWNFVAPLPNPLAE 336
W + R + ++ GG A S C Y+P D+W + L P
Sbjct: 446 WQPKTPLEVARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGW 505
Query: 337 FSACECKGKIYVIGGYTTRDRN-----MNILQYCPSSDMWTLFETCDVHIRKQQMVSVEE 391
A ++YV+GG R + + Y P++ W+ V + + ++
Sbjct: 506 HCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHG 565
Query: 392 TIYIVGG 398
Y+VGG
Sbjct: 566 RAYLVGG 572
Score = 47.4 bits (111), Expect = 3e-05
Identities = 30/134 (22%), Positives = 61/134 (45%), Gaps = 16/134 (11%)
Query: 218 SMLRYEEMTERWFPLANNLPPDLVNVRGYGSAI-LDNYLFIVGGYRITSQ----EISAAH 272
S+ Y+ ++ W L P+L RG+ A+ L + ++++GG ++ + ++
Sbjct: 482 SVCAYDPASDSWQEL-----PNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVE 536
Query: 273 SYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSN------VECYNPEQDAWNF 326
Y+P+T +W A + S + A++ + Y +GG ++C++PE + W
Sbjct: 537 CYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWTE 596
Query: 327 VAPLPNPLAEFSAC 340
LP S C
Sbjct: 597 DDELPEATVGVSCC 610
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 105 bits (261), Expect = 1e-22
Identities = 72/251 (28%), Positives = 116/251 (46%), Gaps = 23/251 (9%)
Query: 186 REARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLVNVRG 245
R A + T LV LG L L + Y+E W LA P D +
Sbjct: 332 RTAIRSDTTHLVTLGGVLRQQLVVSK------ELRMYDEKAHEWKSLA---PMDAPRYQ- 381
Query: 246 YGSAILDNYLFIVGGYRITSQE----ISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNS 301
+G A++ N+L++VGG + + ++P N+W+QVAS+N+KR+ F L A+
Sbjct: 382 HGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKG 441
Query: 302 KLYAIGGQ----AVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDR 357
LYA+GG+ + VECYNP + W +VA + P + G +Y+ GG T
Sbjct: 442 YLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTF 501
Query: 358 NMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLT 417
++ + P +D W M +V E +Y++GG R +S +D+L+
Sbjct: 502 QKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGG-----NHFRGTSDYDDVLS 556
Query: 418 VQSYNTVTRQW 428
+ Y+ + QW
Sbjct: 557 CEYYSPILDQW 567
Score = 88.2 bits (217), Expect = 2e-17
Identities = 116/500 (23%), Positives = 193/500 (38%), Gaps = 101/500 (20%)
Query: 13 DRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVLDFINAG 72
D +PV + + SDYF+A++ GM+E +L G+S GLR ++DFI
Sbjct: 102 DDAFPVHRVMMASASDYFKAMFTGGMKEQ------DLMCIKLHGVSKVGLRKIIDFIYTA 155
Query: 73 GAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQ----LLLSQVRLN 128
MD L + +EAASFLQ+ +L L+S V L+
Sbjct: 156 KL------------------SLNMDN---LQDTLEAASFLQILPVLDFCKVFLISGVTLD 194
Query: 129 NCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQA--PGDVSLKQ--- 183
NC+E+ R+A Y L ++ + F++ +F +L +F L A SLK
Sbjct: 195 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTE 254
Query: 184 -----------RLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPL 232
RL E RM L+ F PL P ++ Y + + F
Sbjct: 255 LELFKATCRWLRLEEPRMDFAAKLMKNIRF---PLM------TPQELINYVQTVD--FMR 303
Query: 233 ANNLPPDLV------NVRGYGSAILDN----------YLFIVGG----YRITSQEISAAH 272
+N +L+ + Y ++ + +L +GG + S+E+
Sbjct: 304 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKEL---R 360
Query: 273 SYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQ---------AVSNVECYNPEQDA 323
Y+ +EW +A M+ R + + + LY +GGQ AV V ++P +
Sbjct: 361 MYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK 420
Query: 324 WNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRK 383
W VA L F KG +Y +GG + Y P ++ WT
Sbjct: 421 WMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYG 480
Query: 384 QQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLT 443
+YI GG H+ + Q E + ++ T +W+ T+ GL+
Sbjct: 481 HAGTVYGGVMYISGGITHD------TFQKE----LMCFDPDTDKWIQKAPMTTVRGLHCM 530
Query: 444 CALHNDGIYIMSRDVTLSTS 463
C + + +Y++ + TS
Sbjct: 531 CTV-GERLYVIGGNHFRGTS 549
Score = 65.5 bits (158), Expect = 1e-10
Identities = 45/169 (26%), Positives = 73/169 (43%), Gaps = 16/169 (9%)
Query: 214 GEPPSMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHS 273
GE P++ Y T W +A P G+ + ++I GG + +
Sbjct: 453 GELPTVECYNPRTNEWTYVAKMSEPHY----GHAGTVYGGVMYISGGITHDTFQ-KELMC 507
Query: 274 YNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQA---------VSNVECYNPEQDAW 324
++P T++W+Q A M R + V +LY IGG V + E Y+P D W
Sbjct: 508 FDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQW 567
Query: 325 NFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNM--NILQYCPSSDMW 371
+A + ++ + KIYV+GGY+ +R M + +Y P D W
Sbjct: 568 TPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW 616
Score = 57.4 bits (137), Expect = 3e-08
Identities = 37/150 (24%), Positives = 76/150 (50%), Gaps = 19/150 (12%)
Query: 202 FLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLVNVRG-YGSAILDNYLFIVGG 260
++ G + +Q E ++ ++ T++W A + VRG + + L+++GG
Sbjct: 491 YISGGITHDTFQKE---LMCFDPDTDKWIQKA-----PMTTVRGLHCMCTVGERLYVIGG 542
Query: 261 --YRITSQ--EISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSN--- 313
+R TS ++ + Y+P ++W +A+M + +S+ + +K+Y +GG + +N
Sbjct: 543 NHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCM 602
Query: 314 ---VECYNPEQDAWNFVAPLPNPLAEFSAC 340
V+ Y+P++D W+ V LP L AC
Sbjct: 603 VEIVQKYDPDKDEWHKVFDLPESLGGIRAC 632
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 105 bits (261), Expect = 1e-22
Identities = 62/215 (28%), Positives = 108/215 (50%), Gaps = 17/215 (7%)
Query: 222 YEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQE----ISAAHSYNPS 277
Y+E + W LA P D + +G A++ N+L++VGG + + ++P
Sbjct: 320 YDERAQEWRSLA---PMDAPRYQ-HGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPR 375
Query: 278 TNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQA----VSNVECYNPEQDAWNFVAPLPNP 333
N+W+QVAS+N+KR+ F L A+ LYA+GG++ ++ VECYNP + W++VA + P
Sbjct: 376 YNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEP 435
Query: 334 LAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETI 393
+ G +Y+ GG T ++ + P +D W M +V + +
Sbjct: 436 HYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKL 495
Query: 394 YIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQW 428
Y++GG R +S +D+L+ + Y+ QW
Sbjct: 496 YVIGG-----NHFRGTSDYDDVLSCEYYSPTLDQW 525
Score = 85.9 bits (211), Expect = 8e-17
Identities = 112/500 (22%), Positives = 190/500 (38%), Gaps = 101/500 (20%)
Query: 13 DRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVLDFINAG 72
D +PV + + SDYF+A++ GM+E +L G++ GL+ ++DFI
Sbjct: 60 DEIFPVHRAMMASASDYFKAMFTGGMKEQ------DLMCIKLHGVNKVGLKKIIDFIYTA 113
Query: 73 GAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQ----LLLSQVRLN 128
MD L + +EAASFLQ+ +L L+S V L+
Sbjct: 114 KL------------------SLNMDN---LQDTLEAASFLQILPVLDFCKVFLISGVSLD 152
Query: 129 NCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQA--PGDVSLKQ--- 183
NC+E+ R+A Y L ++ + F++ +F +L +F L A SLK
Sbjct: 153 NCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTE 212
Query: 184 -----------RLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPL 232
RL + RM L+ F PL P ++ Y + + F
Sbjct: 213 LELFKAACRWLRLEDPRMDYAAKLMKNIRF---PLM------TPQDLINYVQTVD--FMR 261
Query: 233 ANNLPPDLV------NVRGYGSAILDN----------YLFIVGG----YRITSQEISAAH 272
+N +L+ + Y ++ + +L +GG + S+E+
Sbjct: 262 TDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKEL---R 318
Query: 273 SYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQ---------AVSNVECYNPEQDA 323
Y+ EW +A M+ R + + + LY +GGQ AV V ++P +
Sbjct: 319 MYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK 378
Query: 324 WNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRK 383
W VA L F KG +Y +GG + + Y P + W+
Sbjct: 379 WMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYG 438
Query: 384 QQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLT 443
+YI GG H+ N + ++ T +W+ T+ GL+
Sbjct: 439 HAGTVYGGLMYISGGITHDTFQNE----------LMCFDPDTDKWMQKAPMTTVRGLHCM 488
Query: 444 CALHNDGIYIMSRDVTLSTS 463
C + D +Y++ + TS
Sbjct: 489 CTV-GDKLYVIGGNHFRGTS 507
Score = 62.4 bits (150), Expect = 9e-10
Identities = 44/169 (26%), Positives = 72/169 (42%), Gaps = 16/169 (9%)
Query: 214 GEPPSMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHS 273
GE ++ Y W +A P G+ + ++I GG + + +
Sbjct: 411 GELATVECYNPRMNEWSYVAKMSEPHY----GHAGTVYGGLMYISGGITHDTFQ-NELMC 465
Query: 274 YNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQA---------VSNVECYNPEQDAW 324
++P T++W+Q A M R + V KLY IGG V + E Y+P D W
Sbjct: 466 FDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQW 525
Query: 325 NFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNM--NILQYCPSSDMW 371
+A + ++ + KIYV+GGY+ +R M + +Y P D W
Sbjct: 526 TPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEW 574
Score = 60.8 bits (146), Expect = 3e-09
Identities = 38/150 (25%), Positives = 78/150 (52%), Gaps = 19/150 (12%)
Query: 202 FLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLVNVRG-YGSAILDNYLFIVGG 260
++ G + +Q E ++ ++ T++W A + VRG + + + L+++GG
Sbjct: 449 YISGGITHDTFQNE---LMCFDPDTDKWMQKA-----PMTTVRGLHCMCTVGDKLYVIGG 500
Query: 261 --YRITSQ--EISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSN--- 313
+R TS ++ + Y+P+ ++W +A+M + +S+ + +K+Y +GG + +N
Sbjct: 501 NHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCM 560
Query: 314 ---VECYNPEQDAWNFVAPLPNPLAEFSAC 340
V+ Y+PE+D W+ V LP L AC
Sbjct: 561 VEIVQKYDPEKDEWHKVFDLPESLGGIRAC 590
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 103 bits (256), Expect = 5e-22
Identities = 111/493 (22%), Positives = 193/493 (39%), Gaps = 90/493 (18%)
Query: 7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVL 66
VQ+++ + + L S YF AL+ GM+E+ +V + G+ A +++L
Sbjct: 39 VQLQVGQESFKAHRLVLAASSPYFAALFTGGMKES------SKDVVPILGIEAGIFQILL 92
Query: 67 DFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQL----LL 122
DFI G G V+ + EL+ AA LQ+T ++ L L
Sbjct: 93 DFIYTGIVNIG---------------------VNNVQELIIAADMLQLTEVVHLCCEFLK 131
Query: 123 SQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAP----GD 178
Q+ NC+ +++ ++ DL E ++ VHF EV +F L +
Sbjct: 132 GQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEE 191
Query: 179 VSLKQRLREARMTGTPVLVALG----------DFLGGPLAPHPYQGEPPSMLRYEEMTER 228
+S++ + +L LG D + PL P P +L+Y E
Sbjct: 192 LSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLP------PQRLLKYIEGVSD 245
Query: 229 W------------------FPLANNLPPDLVNVRGYGSAILDNYLFIVGGYR-------I 263
+ P N L + YL+ VGGY
Sbjct: 246 FNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWS 305
Query: 264 TSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSNV----ECYNP 319
S+ +S ++ + W V+S++Q RS + + +YAIGG+ S + ECY+P
Sbjct: 306 DSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDP 365
Query: 320 EQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDV 379
W VA + +P C C G IY +GG+ + I ++ P + W + V
Sbjct: 366 VTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAV 425
Query: 380 HIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSG 439
++ IY++GG S++ ++ + + Y+ ++++W L ++
Sbjct: 426 SRYYFGCCEMQGLIYVIGGI---------SNEGIELRSFEVYDPLSKRWSPLPPMGTRRA 476
Query: 440 LNLTCALHNDGIY 452
L A ND IY
Sbjct: 477 Y-LGVAALNDCIY 488
Score = 66.2 bits (160), Expect = 6e-11
Identities = 41/139 (29%), Positives = 65/139 (46%), Gaps = 23/139 (16%)
Query: 222 YEEMTERWFPLANNLPPDLVNVRGY-GSAILDNYLFIVGGYRITSQEISAAHSYNPSTNE 280
Y+ +++RW PL P + R Y G A L++ ++ VGG+ T + Y+ +
Sbjct: 458 YDPLSKRWSPL-----PPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEK 512
Query: 281 WLQVASMNQKRSNFKLVAVNSKLYAIGGQAVS----------NVECYNPEQDAWNFVAPL 330
W++VASM R+ +VAVN LY GG++ S +VE YNP D W
Sbjct: 513 WVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTW------ 566
Query: 331 PNPLAEFSACECKGKIYVI 349
+ C+G + V+
Sbjct: 567 -TEIGNMITSRCEGGVAVL 584
Score = 60.1 bits (144), Expect = 5e-09
Identities = 35/138 (25%), Positives = 64/138 (46%), Gaps = 11/138 (7%)
Query: 246 YGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYA 305
+G + ++++GG E+ + Y+P + W + M +R+ + A+N +Y+
Sbjct: 430 FGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYS 489
Query: 306 IGG-----QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNM- 359
+GG A+ VE Y+ E++ W VA + P A G +YV GG ++ +
Sbjct: 490 VGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLA 549
Query: 360 -----NILQYCPSSDMWT 372
++ Y P SD WT
Sbjct: 550 PGTLDSVEVYNPHSDTWT 567
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 103 bits (256), Expect = 5e-22
Identities = 111/493 (22%), Positives = 193/493 (39%), Gaps = 90/493 (18%)
Query: 7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVL 66
VQ+++ + + L S YF AL+ GM+E+ +V + G+ A +++L
Sbjct: 39 VQLQVGQESFKAHRLVLAASSPYFAALFTGGMKES------SKDVVPILGIEAGIFQILL 92
Query: 67 DFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQL----LL 122
DFI G G V+ + EL+ AA LQ+T ++ L L
Sbjct: 93 DFIYTGIVNIG---------------------VNNVQELIIAADMLQLTEVVHLCCEFLK 131
Query: 123 SQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAP----GD 178
Q+ NC+ +++ ++ DL E ++ VHF EV +F L +
Sbjct: 132 GQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEE 191
Query: 179 VSLKQRLREARMTGTPVLVALG----------DFLGGPLAPHPYQGEPPSMLRYEEMTER 228
+S++ + +L LG D + PL P P +L+Y E
Sbjct: 192 LSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLP------PQRLLKYIEGVSD 245
Query: 229 W------------------FPLANNLPPDLVNVRGYGSAILDNYLFIVGGYR-------I 263
+ P N L + YL+ VGGY
Sbjct: 246 FNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWS 305
Query: 264 TSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSNV----ECYNP 319
S+ +S ++ + W V+S++Q RS + + +YAIGG+ S + ECY+P
Sbjct: 306 DSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDP 365
Query: 320 EQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDV 379
W VA + +P C C G IY +GG+ + I ++ P + W + V
Sbjct: 366 VTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAV 425
Query: 380 HIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSG 439
++ IY++GG S++ ++ + + Y+ ++++W L ++
Sbjct: 426 SRYYFGCCEMQGLIYVIGGI---------SNEGIELRSFEVYDPLSKRWSPLPPMGTRRA 476
Query: 440 LNLTCALHNDGIY 452
L A ND IY
Sbjct: 477 Y-LGVAALNDCIY 488
Score = 56.6 bits (135), Expect = 5e-08
Identities = 31/93 (33%), Positives = 51/93 (54%), Gaps = 6/93 (6%)
Query: 222 YEEMTERWFPLANNLPPDLVNVRGY-GSAILDNYLFIVGGYRITSQEISAAHSYNPSTNE 280
Y+ +++RW PL P + R Y G A L++ ++ VGG+ T + Y+ +
Sbjct: 458 YDPLSKRWSPL-----PPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEK 512
Query: 281 WLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSN 313
W++VASM R+ +VAVN LY GG++ S+
Sbjct: 513 WVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSH 545
Score = 55.5 bits (132), Expect = 1e-07
Identities = 29/111 (26%), Positives = 53/111 (47%), Gaps = 5/111 (4%)
Query: 246 YGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYA 305
+G + ++++GG E+ + Y+P + W + M +R+ + A+N +Y+
Sbjct: 430 FGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYS 489
Query: 306 IGG-----QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGG 351
+GG A+ VE Y+ E++ W VA + P A G +YV GG
Sbjct: 490 VGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
Score = 55.1 bits (131), Expect = 1e-07
Identities = 44/196 (22%), Positives = 83/196 (42%), Gaps = 16/196 (8%)
Query: 214 GEPPSMLR-----YEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEI 268
GE SM+ Y+ +T++W +A+ P G G + ++ +GG+ + ++
Sbjct: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRC----GLGVCVCYGAIYALGGW-VGAEIG 404
Query: 269 SAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSNVEC-----YNPEQDA 323
+ ++P N+W V +M R F + +Y IGG + +E Y+P
Sbjct: 405 NTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKR 464
Query: 324 WNFVAPLPNPLAEFSACECKGKIYVIGGYT-TRDRNMNILQYCPSSDMWTLFETCDVHIR 382
W+ + P+ A IY +GG+ T+D + +Y + W + V
Sbjct: 465 WSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRA 524
Query: 383 KQQMVSVEETIYIVGG 398
+V+V +Y+ GG
Sbjct: 525 GMCVVAVNGLLYVSGG 540
>gi|55741643 kelch-like 14 [Homo sapiens]
Length = 628
Score = 100 bits (249), Expect = 3e-21
Identities = 113/478 (23%), Positives = 195/478 (40%), Gaps = 106/478 (22%)
Query: 54 LRGLSAPGLRLVLDFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQ 113
L+G S+ GLRLVL+++ +D EE+ VS + + Q
Sbjct: 127 LQGCSSIGLRLVLEYLYTANVTL------------SLDTVEEVLSVSKILHIP------Q 168
Query: 114 VTSL-LQLLLSQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGS- 171
VT L +Q L Q+ + N ++ ++A ++GL + ++ +++V + + LL S
Sbjct: 169 VTKLCVQFLNDQISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNFEEMRALLDSL 228
Query: 172 PPQAPGDVSLKQRL-------REARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEE 224
PP +++L Q RE RM P L+ F P + + +R +
Sbjct: 229 PPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDP 288
Query: 225 M------------------------------TERWFPLANNLPP---------------- 238
+ ++ L LPP
Sbjct: 289 VCQKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDE 348
Query: 239 ----DLVNVRGYGSA-----ILDNYLFIVGGYRITSQEISAAHS------YNPSTNEWLQ 283
++ + Y SA ++N+LF++GG + HS Y+P N W+Q
Sbjct: 349 KKTWKILTIMPYNSAHHCVVEVENFLFVLGGE--DQWNPNGKHSTNFVSRYDPRFNSWIQ 406
Query: 284 VASMNQKRSNFKLVAVNSKLYAIGGQ----AVSNVECYNPEQDAWNFVAPLPNPLAEFSA 339
+ M ++R++F ++ LY IGG+ +S+VECYN E + W +V+ LP PLA +
Sbjct: 407 LPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAG 466
Query: 340 CECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVE--ETIYIVG 397
GKIY+ GG + + Y P D+W RKQ M + T+ ++
Sbjct: 467 AVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWA---------RKQDMNTKRAIHTLAVMN 517
Query: 398 GCLHELGPNRRSSQSE-DMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIM 454
L+ +G N S D++ V+ Y+ QW L+ + CA+ +D IY++
Sbjct: 518 DRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLV 575
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 99.8 bits (247), Expect = 5e-21
Identities = 134/586 (22%), Positives = 216/586 (36%), Gaps = 133/586 (22%)
Query: 7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVL 66
V + + +P K L SDYFRA++ GMREA +V +L+G+SA GLR ++
Sbjct: 65 VVLTINREAFPAHKVVLAACSDYFRAMFTGGMREA------SQDVIELKGVSARGLRHII 118
Query: 67 -----------------------------------DFINAGGAREGWL-LGPRGEKGGGV 90
+F+ A + E L +G
Sbjct: 119 DFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLA 178
Query: 91 DEDEEMDEVSL--LSELVEAASFLQVT-SLLQLLLSQVRLNNCLEMYRLAQVYGLPDLQE 147
E +D + ++ E FL++ L L RL +C E+ DL
Sbjct: 179 SLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEI----------DLFR 228
Query: 148 ACLRFMV------VHFHEVLCKPQFHLLGSPPQAPG---------DVSLKQRL------- 185
A +R++ VLC +F L+ S DV +Q L
Sbjct: 229 AAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQ 288
Query: 186 ------------REARMTGTPVLVALGDFLGGP-------LAPHPYQGEPPSMLRYEEMT 226
R A + P LV G G P ++ YQ P + E+T
Sbjct: 289 VLPFRQHEMQSPRTAVRSDVPSLVTFG---GTPYTDSDRSVSSKVYQLPEPGARHFRELT 345
Query: 227 ERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGG----YRITSQEISAAHSYNPSTNEWL 282
E ++ A+LDN++++ GG YR + A + Y+P N WL
Sbjct: 346 EMEVGCSHTCV-----------AVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWL 394
Query: 283 QVASMNQKRSNFKLVAVNSKLYAIGGQ----AVSNVECYNPEQDAWNFVAPLPNPLAEFS 338
++ +M + R F+L + +YA GG+ ++++VE Y P ++ W + L +
Sbjct: 395 RLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHA 454
Query: 339 ACECKGKIYVIGGYTTRDRNMNILQ-YCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVG 397
G++Y+ GGY + L Y P +D W MV IY +G
Sbjct: 455 GAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALG 514
Query: 398 GCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLY---LKENTSKSGLNLTCALHNDGIYIM 454
G + + + D+L V+ Y T QW ++ S++G C L IYI+
Sbjct: 515 GRMDHV------DRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAG----CCLLERKIYIV 564
Query: 455 SRDVTLSTSLEHRVFLKYNIFSDSWEAFRRFPAFGHNLLVSSLYLP 500
+ + YN +D WE FP + + + LP
Sbjct: 565 G-GYNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAGIACAPVLLP 609
>gi|227497736 T-cell activation kelch repeat protein [Homo sapiens]
Length = 601
Score = 95.9 bits (237), Expect = 8e-20
Identities = 97/368 (26%), Positives = 158/368 (42%), Gaps = 61/368 (16%)
Query: 142 LPDLQEACLRFMVVH--FHEVLCKPQF-HLLGSPPQAPGDVSLKQRLREARMTGTPVLVA 198
LP++ C+RF ++ F E + PQF + G + + MT + +++
Sbjct: 232 LPEIFAKCIRFPLMEDTFIEKI-PPQFAQAIAKSCVEKGPSNTNGCTQRLGMTASEMIIC 290
Query: 199 LGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLVNVRGYGSAIL-DNYLFI 257
A H + G+ ++ + +T R F L PP+ ++R G + DN ++I
Sbjct: 291 FD-------AAHKHSGKKQTVPCLDIVTGRVFKLCK--PPN--DLREVGILVSPDNDIYI 339
Query: 258 VGGYRITSQEISAAHS-------YNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQ- 309
GGYR +S E+S H Y+ STN WL S+ + R KLV K+YAIGG+
Sbjct: 340 AGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRV 399
Query: 310 -------AVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNIL 362
++ +VECY+ ++ W V +P + +A E K KIYV+ G L
Sbjct: 400 YEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQGEF-------FL 452
Query: 363 QYCPSSDMWTLFETCDV-HIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSY 421
Y P D W V I+ V + YI G C G ++R M TV++Y
Sbjct: 453 FYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTC----GNHQR------MFTVEAY 502
Query: 422 NTVTRQWLYLKENTSKSGLN--LTCALHNDGIYIMSRDVTLSTSLEHRVF--------LK 471
+ +W K+ +N L L + +++ R ++E VF +
Sbjct: 503 DIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVR--ATQVTVEEHVFRTSRKNSLYQ 560
Query: 472 YNIFSDSW 479
Y+ +D W
Sbjct: 561 YDDIADQW 568
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 95.5 bits (236), Expect = 1e-19
Identities = 74/244 (30%), Positives = 118/244 (48%), Gaps = 22/244 (9%)
Query: 249 AILDNYLFIVGGYRITSQEISAA----HSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLY 304
A+L ++FI GG AA + Y+P +W++VASMNQ+R +F L ++ L
Sbjct: 341 AVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLV 400
Query: 305 AIGGQ----AVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGG--YTTRDRN 358
AIGG+ A+S+VE Y+P+ D+W++VA LP + K +Y+ GG Y
Sbjct: 401 AIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDFVYISGGHDYQIGPYR 460
Query: 359 MNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTV 418
N+L Y +D+W M S+ ++IY +GG N S + D+L V
Sbjct: 461 KNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGS----DDNIESMERFDVLGV 516
Query: 419 QSYNTVTRQWLY---LKENTSKSGLNLTCALHNDGIYIMSRDVTLSTSLEHRVFLKYNIF 475
++Y+ QW L S+SG+ A+ IYI+ +T+ V + Y+
Sbjct: 517 EAYSPQCNQWTRVAPLLHANSESGV----AVWEGRIYILGGYSWENTAFSKTVQV-YDRE 571
Query: 476 SDSW 479
+D W
Sbjct: 572 ADKW 575
Score = 69.7 bits (169), Expect = 6e-12
Identities = 111/481 (23%), Positives = 185/481 (38%), Gaps = 77/481 (16%)
Query: 12 EDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVLDFINA 71
+++ P + L SDYF +++ GMREA +E +L G S GL+ V+DF+
Sbjct: 53 DEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEV------ELIGASYIGLKAVVDFLYG 106
Query: 72 GGAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLL----QLLLSQVRL 127
G GG +D ++E A LQ+ +++ + L +V
Sbjct: 107 ---------GELVLDGGNID------------YVLETAHLLQIWTVVDFCCEYLEQEVSE 145
Query: 128 NNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQF-----------HLLGSPPQAP 176
+N L + LA +Y L L F++ HF + P F +L S Q
Sbjct: 146 DNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRE 205
Query: 177 GDVSLKQRLREARMTGTPVLVA----LGDFLGGPLAP-----HPYQGEPPSMLRYEEMTE 227
+ L Q + +T P A + + + PL P H + S+L E E
Sbjct: 206 CEHDLLQAALQ-WLTQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCE 264
Query: 228 RWFPLA----NNL--PPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSY-NPSTNE 280
+ A NNL P + R + LF+ G E+S Y + + +
Sbjct: 265 GFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCYLDAKSEQ 324
Query: 281 WLQVASMNQKRSN--------FKLVAVNSKLYAIGGQAVSN-VECYNPEQDAWNFVAPLP 331
W++ + +RS+ F +A S GG A SN + Y+P W VA +
Sbjct: 325 WVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMN 384
Query: 332 NPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEE 391
+F + + IGG ++ Y P +D W+ ++
Sbjct: 385 QRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKD 444
Query: 392 TIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGI 451
+YI GG +++GP R++ + Y+ T W + T+ G + C+L D I
Sbjct: 445 FVYISGGHDYQIGPYRKN--------LLCYDHRTDVWEERRPMTTARGWHSMCSL-GDSI 495
Query: 452 Y 452
Y
Sbjct: 496 Y 496
Score = 52.4 bits (124), Expect = 1e-06
Identities = 41/147 (27%), Positives = 66/147 (44%), Gaps = 19/147 (12%)
Query: 210 HPYQGEP--PSMLRYEEMTERWFPLANNLPPDLVNVRGYGSAI-LDNYLFIVGGY--RIT 264
H YQ P ++L Y+ T+ W P + RG+ S L + ++ +GG I
Sbjct: 452 HDYQIGPYRKNLLCYDHRTDVW---EERRP--MTTARGWHSMCSLGDSIYSIGGSDDNIE 506
Query: 265 SQE---ISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSN------VE 315
S E + +Y+P N+W +VA + S + ++Y +GG + N V+
Sbjct: 507 SMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQ 566
Query: 316 CYNPEQDAWNFVAPLPNPLAEFSACEC 342
Y+ E D W+ LP +A SAC C
Sbjct: 567 VYDREADKWSRGVDLPKAIAGGSACVC 593
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 94.0 bits (232), Expect = 3e-19
Identities = 59/196 (30%), Positives = 97/196 (49%), Gaps = 17/196 (8%)
Query: 247 GSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAI 306
G+A+L++ L+ VGG+ S +++ +Y+ TNEW VA MN +RS+ + V KLYA+
Sbjct: 388 GAAVLNDLLYAVGGFD-GSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAV 446
Query: 307 GG------QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMN 360
GG Q +S VE YNP + W +VA + + G++Y GG+ +
Sbjct: 447 GGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKS 506
Query: 361 ILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQS 420
+ Y P ++ W ++ R + +V +Y+VGG S ++ +V+
Sbjct: 507 VEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGG----------DDGSCNLASVEY 556
Query: 421 YNTVTRQWLYLKENTS 436
YN VT +W L N S
Sbjct: 557 YNPVTDKWTLLPTNMS 572
Score = 85.5 bits (210), Expect = 1e-16
Identities = 52/164 (31%), Positives = 78/164 (47%), Gaps = 9/164 (5%)
Query: 218 SMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQE-ISAAHSYNP 276
S+ Y T WF +A P G +++ L+ VGGY S++ +S YNP
Sbjct: 410 SVEAYSYKTNEWFFVA----PMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNP 465
Query: 277 STNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQ----AVSNVECYNPEQDAWNFVAPLPN 332
+TNEW+ VA M+ +RS + ++ +LYA GG +VE Y+P + W VA +
Sbjct: 466 ATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNM 525
Query: 333 PLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFET 376
C G +YV+GG ++ Y P +D WTL T
Sbjct: 526 CRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPT 569
Score = 75.9 bits (185), Expect = 8e-14
Identities = 68/276 (24%), Positives = 115/276 (41%), Gaps = 29/276 (10%)
Query: 214 GEPPSMLR----YEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEIS 269
G+ P +R Y+ +RW +A LP G + +++ VGG+ S +
Sbjct: 308 GQAPKAIRSVECYDFEEDRWDQIAE-LPSRRCRA---GVVFMAGHVYAVGGFN-GSLRVR 362
Query: 270 AAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWN 325
Y+ ++W +ASM ++RS +N LYA+GG +++VE Y+ + + W
Sbjct: 363 TVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWF 422
Query: 326 FVAPLPNPLAEFSACECKGKIYVIGGYTTRDRN--MNILQYCPSSDMWTLFETCDVHIRK 383
FVAP+ + +GK+Y +GGY R + QY P+++ W
Sbjct: 423 FVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSG 482
Query: 384 QQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLT 443
+ + +Y GG H+ GP R S V+ Y+ T W + +
Sbjct: 483 AGVGVLSGQLYATGG--HD-GPLVRKS-------VEVYDPGTNTWKQVADMNMCRRNAGV 532
Query: 444 CALHNDGIYIMSRDVTLSTSLEHRVFLKYNIFSDSW 479
CA+ N +Y++ D S YN +D W
Sbjct: 533 CAV-NGLLYVVGGD---DGSCNLASVEYYNPVTDKW 564
Score = 63.2 bits (152), Expect = 5e-10
Identities = 85/364 (23%), Positives = 137/364 (37%), Gaps = 76/364 (20%)
Query: 105 LVEAASFLQVTSLLQ----LLLSQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEV 160
L+ AAS LQ+ + Q L SQ+ NCL + A V+ DL + + HF EV
Sbjct: 123 LLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEV 182
Query: 161 LCKPQF---------HLLGSPPQAPGDVSLKQRLREA--------RMTGTPVLVALGDFL 203
+ +F L+ S VS ++++ EA + T + L + +
Sbjct: 183 MLGEEFLSLSLDQVCSLISSDKLT---VSSEEKVFEAVISWINYEKETRLEHMAKLMEHV 239
Query: 204 GGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPD-LVNVRGYGSAILDNYLFIVGGYR 262
PL P Y + + E NN D L+ Y LD L I
Sbjct: 240 RLPLLPRDYL--------VQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIK---- 287
Query: 263 ITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQA---VSNVECYNP 319
NP T + R+ L V + +GGQA + +VECY+
Sbjct: 288 ------------NPRT----------KPRTPVSLPKV---MIVVGGQAPKAIRSVECYDF 322
Query: 320 EQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDV 379
E+D W+ +A LP+ G +Y +GG+ R + Y D WT +
Sbjct: 323 EEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQE 382
Query: 380 HIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKE-NTSKS 438
+ + +Y VGG S + +V++Y+ T +W ++ NT +S
Sbjct: 383 RRSTLGAAVLNDLLYAVGG----------FDGSTGLASVEAYSYKTNEWFFVAPMNTRRS 432
Query: 439 GLNL 442
+ +
Sbjct: 433 SVGV 436
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 93.6 bits (231), Expect = 4e-19
Identities = 83/301 (27%), Positives = 135/301 (44%), Gaps = 52/301 (17%)
Query: 165 QFHLLGSPPQAPGDVSLKQRLREARMTG-TPVLVALG--DFLGGPLAPHPYQGEPPSMLR 221
++H+LG+ +P R R R TG + V+V +G + +GG P+
Sbjct: 290 RYHILGNEMMSP-------RTRPRRSTGYSEVIVVVGGCERVGGFNLPYTEC-------- 334
Query: 222 YEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEW 281
Y+ +T W LA P+ Y L N + + GG RI S+++ YN N W
Sbjct: 335 YDPVTGEWKSLAKL--PEFTKSE-YAVCALRNDILVSGG-RINSRDVWI---YNSQLNIW 387
Query: 282 LQVASMNQKRSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWNFVAPLPNPLAEF 337
++VAS+N+ R K+ + K+Y +GG +S+VECY+ + W VAPL ++
Sbjct: 388 IRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSP 447
Query: 338 SACECKGKIYVIGG----YTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETI 393
+ C GK++VIGG T D+ + Y P ++ W L + R VS+ I
Sbjct: 448 AVTSCVGKLFVIGGGPDDNTCSDK---VQSYDPETNSWLLRAAIPIAKRCITAVSLNNLI 504
Query: 394 YIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYI 453
Y+ GG + Y+ V W+++ +NT N ++ N IYI
Sbjct: 505 YVAGGLTK---------------AIYCYDPVEDYWMHV-QNTFSRQENCGMSVCNGKIYI 548
Query: 454 M 454
+
Sbjct: 549 L 549
Score = 72.4 bits (176), Expect = 9e-13
Identities = 103/455 (22%), Positives = 176/455 (38%), Gaps = 71/455 (15%)
Query: 7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVL 66
V I +E + +P + L S YFRA++ + RE+ + ++ G+ A + L
Sbjct: 68 VIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREM------LVEINGILAEAMECFL 121
Query: 67 DFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQLLLSQVR 126
++ G + E + E + ++S+L + A FL+ Q+
Sbjct: 122 QYVYTGKVK------ITTENVQYLFETSSLFQISVLRD--ACAKFLE---------EQLD 164
Query: 127 LNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQF------HLLGSPPQAPGDVS 180
NCL + R A + L L C F + F +V +F L+ +
Sbjct: 165 PCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIG 224
Query: 181 LKQRLREARMTGT--------PVLVALGDFLGGPLAPHP------------YQGEPPSML 220
++ + EA M P+L L + PL HP Q P
Sbjct: 225 KEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLL-HPNYFVQTVEVDQLIQNSPECYQ 283
Query: 221 RYEEMTERWFPLANNLPPDLVNVR---GYGSAILDNYLFIVGG-YRITSQEISAAHSYNP 276
E R+ L N + R GY I+ +VGG R+ + Y+P
Sbjct: 284 LLHE-ARRYHILGNEMMSPRTRPRRSTGYSEVIV-----VVGGCERVGGFNLPYTECYDP 337
Query: 277 STNEWLQVASMNQ-KRSNFKLVAVNSKLYAIGGQAVS-NVECYNPEQDAWNFVAPLPNPL 334
T EW +A + + +S + + A+ + + GG+ S +V YN + + W VA L
Sbjct: 338 VTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGR 397
Query: 335 AEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIY 394
GK+YV+GGY ++R ++ Y S+ WT + + S ++
Sbjct: 398 WRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLF 457
Query: 395 IVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWL 429
++GG GP+ + + VQSY+ T WL
Sbjct: 458 VIGG-----GPDDNTCSDK----VQSYDPETNSWL 483
Score = 57.8 bits (138), Expect = 2e-08
Identities = 35/119 (29%), Positives = 57/119 (47%), Gaps = 2/119 (1%)
Query: 255 LFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSNV 314
LF++GG + SY+P TN WL A++ + V++N+ +Y GG + +
Sbjct: 456 LFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKA-I 514
Query: 315 ECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTR-DRNMNILQYCPSSDMWT 372
CY+P +D W V + C GKIY++GG + IL Y P++ + T
Sbjct: 515 YCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIIT 573
Score = 45.4 bits (106), Expect = 1e-04
Identities = 23/90 (25%), Positives = 43/90 (47%), Gaps = 11/90 (12%)
Query: 251 LDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIG--- 307
L+N +++ GG A + Y+P + W+ V + ++ N + N K+Y +G
Sbjct: 500 LNNLIYVAGGLT------KAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRR 553
Query: 308 --GQAVSNVECYNPEQDAWNFVAPLPNPLA 335
G+A + CY+P VA +P P++
Sbjct: 554 ENGEATDTILCYDPATSIITGVAAMPRPVS 583
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 92.0 bits (227), Expect = 1e-18
Identities = 106/505 (20%), Positives = 194/505 (38%), Gaps = 78/505 (15%)
Query: 13 DRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVLDFINAG 72
DR P + L SDYF A++ + +REA +E ++ G+ L ++ + G
Sbjct: 182 DRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI------KMEGVEPNSLWSLIQYAYTG 235
Query: 73 GAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQ----LLLSQVRLN 128
+ ED + L+ A LQ++ +++ L+ Q+ +
Sbjct: 236 RLE--------------LKEDN-------IECLLSTACLLQLSQVVEACCKFLMKQLHPS 274
Query: 129 NCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQA----------PGD 178
NCL + A G DL + + + HF EV+ +F LL + A P +
Sbjct: 275 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNE 334
Query: 179 VSLKQRLR-------EARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEE------- 224
++ L E R L+A ++ PL + + + + + +
Sbjct: 335 ETILNALLTWVRHDLEQRRKDLSKLLA---YIRLPLLAPQFLADMENNVLFRDDIECQKL 391
Query: 225 -MTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQ 283
M + L P L + R LF VGG T S Y+ TN W
Sbjct: 392 IMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSI-EKYDLRTNMWTP 450
Query: 284 VASMNQKRSNFKLVAVNSKLYAIGGQ----AVSNVECYNPEQDAWNFVAPLPNPLAEFSA 339
VA+MN +R F + ++ KLY +GG+ ++ VECYNP+ W+ + P+
Sbjct: 451 VANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGV 510
Query: 340 CECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGC 399
+G +Y +GG+ + ++ P + W T + + +Y VGG
Sbjct: 511 AVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG- 569
Query: 400 LHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVT 459
S + +V+ ++ T +W + + + G + N +Y +
Sbjct: 570 ---------RDGSSCLKSVECFDPHTNKWTLCAQMSKRRG-GVGVTTWNGLLYAIGGHDA 619
Query: 460 LSTSLEHRV---FLKYNIFSDSWEA 481
+++L R+ +Y+ +D W A
Sbjct: 620 PASNLTSRLSDCVERYDPKTDMWTA 644
Score = 84.0 bits (206), Expect = 3e-16
Identities = 54/217 (24%), Positives = 98/217 (45%), Gaps = 25/217 (11%)
Query: 222 YEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEW 281
Y T+ W + +PP + G G A+L+ ++ VGG+ S ++ ++P +W
Sbjct: 488 YNPKTKTW----SVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSY-LNTVERWDPQARQW 542
Query: 282 LQVASMNQKRSNFKLVAVNSKLYAIGGQ----AVSNVECYNPEQDAWNFVAPLPNPLAEF 337
VA+M+ RS + ++ KLYA+GG+ + +VEC++P + W A +
Sbjct: 543 NFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGV 602
Query: 338 SACECKGKIYVIGGYTTRDRNMN------ILQYCPSSDMWTLFETCDVHIRKQQMVSVEE 391
G +Y IGG+ N+ + +Y P +DMWT + + + + +
Sbjct: 603 GVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGD 662
Query: 392 TIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQW 428
+Y VGG + N TV++Y+ T +W
Sbjct: 663 KLYAVGGYDGQAYLN----------TVEAYDPQTNEW 689
Score = 71.6 bits (174), Expect = 2e-12
Identities = 51/164 (31%), Positives = 72/164 (43%), Gaps = 14/164 (8%)
Query: 222 YEEMTERWFPLAN--NLPPDLVNVRG-YGSAILDNYLFIVGGYRITSQEISAAHSYNPST 278
Y ERW P A N + R G A+L L+ VGG R S + + ++P T
Sbjct: 528 YLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG-RDGSSCLKSVECFDPHT 586
Query: 279 NEWLQVASMNQKRSNFKLVAVNSKLYAIGGQ--AVSN--------VECYNPEQDAWNFVA 328
N+W A M+++R + N LYAIGG SN VE Y+P+ D W VA
Sbjct: 587 NKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVA 646
Query: 329 PLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWT 372
+ C K+Y +GGY + + Y P ++ WT
Sbjct: 647 SMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWT 690
Score = 56.6 bits (135), Expect = 5e-08
Identities = 34/95 (35%), Positives = 49/95 (51%), Gaps = 9/95 (9%)
Query: 245 GYGSAILDNYLFIVGGY-----RITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAV 299
G G + L+ +GG+ +TS+ Y+P T+ W VASM+ R + +
Sbjct: 601 GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLL 660
Query: 300 NSKLYAIGG---QAVSN-VECYNPEQDAWNFVAPL 330
KLYA+GG QA N VE Y+P+ + W VAPL
Sbjct: 661 GDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 695
Score = 40.4 bits (93), Expect = 0.004
Identities = 26/80 (32%), Positives = 43/80 (53%), Gaps = 7/80 (8%)
Query: 221 RYEEMTERWFPLAN-NLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTN 279
RY+ T+ W +A+ ++ D V V +L + L+ VGGY + ++ +Y+P TN
Sbjct: 634 RYDPKTDMWTAVASMSISRDAVGV-----CLLGDKLYAVGGYDGQAY-LNTVEAYDPQTN 687
Query: 280 EWLQVASMNQKRSNFKLVAV 299
EW QVA + R+ +V V
Sbjct: 688 EWTQVAPLCLGRAGACVVTV 707
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 92.0 bits (227), Expect = 1e-18
Identities = 106/505 (20%), Positives = 194/505 (38%), Gaps = 78/505 (15%)
Query: 13 DRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVLDFINAG 72
DR P + L SDYF A++ + +REA +E ++ G+ L ++ + G
Sbjct: 228 DRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI------KMEGVEPNSLWSLIQYAYTG 281
Query: 73 GAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQ----LLLSQVRLN 128
+ ED + L+ A LQ++ +++ L+ Q+ +
Sbjct: 282 RLE--------------LKEDN-------IECLLSTACLLQLSQVVEACCKFLMKQLHPS 320
Query: 129 NCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQA----------PGD 178
NCL + A G DL + + + HF EV+ +F LL + A P +
Sbjct: 321 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNE 380
Query: 179 VSLKQRLR-------EARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEE------- 224
++ L E R L+A ++ PL + + + + + +
Sbjct: 381 ETILNALLTWVRHDLEQRRKDLSKLLA---YIRLPLLAPQFLADMENNVLFRDDIECQKL 437
Query: 225 -MTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQ 283
M + L P L + R LF VGG T S Y+ TN W
Sbjct: 438 IMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSI-EKYDLRTNMWTP 496
Query: 284 VASMNQKRSNFKLVAVNSKLYAIGGQ----AVSNVECYNPEQDAWNFVAPLPNPLAEFSA 339
VA+MN +R F + ++ KLY +GG+ ++ VECYNP+ W+ + P+
Sbjct: 497 VANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGV 556
Query: 340 CECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGC 399
+G +Y +GG+ + ++ P + W T + + +Y VGG
Sbjct: 557 AVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG- 615
Query: 400 LHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVT 459
S + +V+ ++ T +W + + + G + N +Y +
Sbjct: 616 ---------RDGSSCLKSVECFDPHTNKWTLCAQMSKRRG-GVGVTTWNGLLYAIGGHDA 665
Query: 460 LSTSLEHRV---FLKYNIFSDSWEA 481
+++L R+ +Y+ +D W A
Sbjct: 666 PASNLTSRLSDCVERYDPKTDMWTA 690
Score = 84.0 bits (206), Expect = 3e-16
Identities = 54/217 (24%), Positives = 98/217 (45%), Gaps = 25/217 (11%)
Query: 222 YEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEW 281
Y T+ W + +PP + G G A+L+ ++ VGG+ S ++ ++P +W
Sbjct: 534 YNPKTKTW----SVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSY-LNTVERWDPQARQW 588
Query: 282 LQVASMNQKRSNFKLVAVNSKLYAIGGQ----AVSNVECYNPEQDAWNFVAPLPNPLAEF 337
VA+M+ RS + ++ KLYA+GG+ + +VEC++P + W A +
Sbjct: 589 NFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGV 648
Query: 338 SACECKGKIYVIGGYTTRDRNMN------ILQYCPSSDMWTLFETCDVHIRKQQMVSVEE 391
G +Y IGG+ N+ + +Y P +DMWT + + + + +
Sbjct: 649 GVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGD 708
Query: 392 TIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQW 428
+Y VGG + N TV++Y+ T +W
Sbjct: 709 KLYAVGGYDGQAYLN----------TVEAYDPQTNEW 735
Score = 71.6 bits (174), Expect = 2e-12
Identities = 51/164 (31%), Positives = 72/164 (43%), Gaps = 14/164 (8%)
Query: 222 YEEMTERWFPLAN--NLPPDLVNVRG-YGSAILDNYLFIVGGYRITSQEISAAHSYNPST 278
Y ERW P A N + R G A+L L+ VGG R S + + ++P T
Sbjct: 574 YLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG-RDGSSCLKSVECFDPHT 632
Query: 279 NEWLQVASMNQKRSNFKLVAVNSKLYAIGGQ--AVSN--------VECYNPEQDAWNFVA 328
N+W A M+++R + N LYAIGG SN VE Y+P+ D W VA
Sbjct: 633 NKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVA 692
Query: 329 PLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWT 372
+ C K+Y +GGY + + Y P ++ WT
Sbjct: 693 SMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWT 736
Score = 56.6 bits (135), Expect = 5e-08
Identities = 34/95 (35%), Positives = 49/95 (51%), Gaps = 9/95 (9%)
Query: 245 GYGSAILDNYLFIVGGY-----RITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAV 299
G G + L+ +GG+ +TS+ Y+P T+ W VASM+ R + +
Sbjct: 647 GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLL 706
Query: 300 NSKLYAIGG---QAVSN-VECYNPEQDAWNFVAPL 330
KLYA+GG QA N VE Y+P+ + W VAPL
Sbjct: 707 GDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 741
Score = 40.4 bits (93), Expect = 0.004
Identities = 26/80 (32%), Positives = 43/80 (53%), Gaps = 7/80 (8%)
Query: 221 RYEEMTERWFPLAN-NLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTN 279
RY+ T+ W +A+ ++ D V V +L + L+ VGGY + ++ +Y+P TN
Sbjct: 680 RYDPKTDMWTAVASMSISRDAVGV-----CLLGDKLYAVGGYDGQAY-LNTVEAYDPQTN 733
Query: 280 EWLQVASMNQKRSNFKLVAV 299
EW QVA + R+ +V V
Sbjct: 734 EWTQVAPLCLGRAGACVVTV 753
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 90.5 bits (223), Expect = 3e-18
Identities = 57/213 (26%), Positives = 100/213 (46%), Gaps = 21/213 (9%)
Query: 222 YEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEW 281
Y+ + ++W +AN G+A+L+ L+ VGG+ S +S+ +YN +NEW
Sbjct: 285 YDPVKDQWTSVANMRDRRST----LGAAVLNGLLYAVGGFD-GSTGLSSVEAYNIKSNEW 339
Query: 282 LQVASMNQKRSNFKLVAVNSKLYAIGG------QAVSNVECYNPEQDAWNFVAPLPNPLA 335
VA MN +RS+ + V LYA+GG Q +S VECYN + W ++A + +
Sbjct: 340 FHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRS 399
Query: 336 EFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYI 395
+Y +GG+ ++ Y P+++ W ++ R + +V +Y+
Sbjct: 400 GAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYV 459
Query: 396 VGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQW 428
VGG S ++ +V+ YN T +W
Sbjct: 460 VGG----------DDGSCNLASVEYYNPTTDKW 482
Score = 85.1 bits (209), Expect = 1e-16
Identities = 50/165 (30%), Positives = 79/165 (47%), Gaps = 9/165 (5%)
Query: 218 SMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQE-ISAAHSYNP 276
S+ Y + WF +A P G ++ L+ VGGY S++ +S YN
Sbjct: 328 SVEAYNIKSNEWFHVA----PMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNA 383
Query: 277 STNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQ----AVSNVECYNPEQDAWNFVAPLPN 332
+TNEW +A M+ +RS + +N+ LYA+GG +VE Y+P +AW VA +
Sbjct: 384 TTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNM 443
Query: 333 PLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETC 377
C G +YV+GG ++ Y P++D WT+ +C
Sbjct: 444 CRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSC 488
Score = 78.6 bits (192), Expect = 1e-14
Identities = 72/276 (26%), Positives = 112/276 (40%), Gaps = 29/276 (10%)
Query: 214 GEPPSMLR----YEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEIS 269
G+ P +R Y+ ERW +A LP G + +F VGG+ S +
Sbjct: 226 GQAPKAIRSVECYDFKEERWHQVAE-LPSRRCRA---GMVYMAGLVFAVGGFN-GSLRVR 280
Query: 270 AAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWN 325
SY+P ++W VA+M +RS +N LYA+GG +S+VE YN + + W
Sbjct: 281 TVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWF 340
Query: 326 FVAPLPNPLAEFSACECKGKIYVIGGYTTRDRN--MNILQYCPSSDMWTLFETCDVHIRK 383
VAP+ + G +Y +GGY R + Y +++ WT
Sbjct: 341 HVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSG 400
Query: 384 QQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLT 443
+ + +Y VGG H+ GP R S V+ Y+ T W + +
Sbjct: 401 AGVGVLNNLLYAVGG--HD-GPLVRKS-------VEVYDPTTNAWRQVADMNMCRRNAGV 450
Query: 444 CALHNDGIYIMSRDVTLSTSLEHRVFLKYNIFSDSW 479
CA+ N +Y++ D S YN +D W
Sbjct: 451 CAV-NGLLYVVGGD---DGSCNLASVEYYNPTTDKW 482
Score = 53.5 bits (127), Expect = 4e-07
Identities = 75/352 (21%), Positives = 135/352 (38%), Gaps = 52/352 (14%)
Query: 105 LVEAASFLQVTSL----LQLLLSQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEV 160
L+ AA LQ+ + + L SQ+ NCL + A ++ DL + HF +V
Sbjct: 41 LLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADV 100
Query: 161 LCKPQFHLLGSPPQAPGDVSLKQRLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSML 220
+ +F LG S K + V+ + H M
Sbjct: 101 VLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVN---------HDKDVRQEFMA 151
Query: 221 RYEEMTERWFPLANNLPPDLVNVRGYGSAILDN------YLFIVGGYRITSQEISAAHSY 274
R E PL LP + + R A++ N YL Y +
Sbjct: 152 RLMEHVR--LPL---LPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLL---------- 196
Query: 275 NPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQA---VSNVECYNPEQDAWNFVAPLP 331
P+ L + + R+ L + + +GGQA + +VECY+ +++ W+ VA LP
Sbjct: 197 -PTEQRILMKSVRTRLRTPMNLPKL---MVVVGGQAPKAIRSVECYDFKEERWHQVAELP 252
Query: 332 NPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEE 391
+ G ++ +GG+ R + Y P D WT ++ R+ + +
Sbjct: 253 SRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWT--SVANMRDRRSTLGAA-- 308
Query: 392 TIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKE-NTSKSGLNL 442
++ G L+ +G S + +V++YN + +W ++ NT +S + +
Sbjct: 309 ---VLNGLLYAVG---GFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGV 354
Score = 30.0 bits (66), Expect = 5.1
Identities = 22/83 (26%), Positives = 40/83 (48%), Gaps = 9/83 (10%)
Query: 222 YEEMTERWFPLANNLPPDLVNV--RGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTN 279
Y+ T W +A+ +N+ R G ++ L++VGG S +++ YNP+T+
Sbjct: 428 YDPTTNAWRQVAD------MNMCRRNAGVCAVNGLLYVVGGDD-GSCNLASVEYYNPTTD 480
Query: 280 EWLQVASMNQKRSNFKLVAVNSK 302
+W V+S ++ V V K
Sbjct: 481 KWTVVSSCMSTGRSYAGVTVIDK 503
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 90.5 bits (223), Expect = 3e-18
Identities = 57/213 (26%), Positives = 100/213 (46%), Gaps = 21/213 (9%)
Query: 222 YEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEW 281
Y+ + ++W +AN G+A+L+ L+ VGG+ S +S+ +YN +NEW
Sbjct: 377 YDPVKDQWTSVANMRDRRST----LGAAVLNGLLYAVGGFD-GSTGLSSVEAYNIKSNEW 431
Query: 282 LQVASMNQKRSNFKLVAVNSKLYAIGG------QAVSNVECYNPEQDAWNFVAPLPNPLA 335
VA MN +RS+ + V LYA+GG Q +S VECYN + W ++A + +
Sbjct: 432 FHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRS 491
Query: 336 EFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYI 395
+Y +GG+ ++ Y P+++ W ++ R + +V +Y+
Sbjct: 492 GAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYV 551
Query: 396 VGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQW 428
VGG S ++ +V+ YN T +W
Sbjct: 552 VGG----------DDGSCNLASVEYYNPTTDKW 574
Score = 85.1 bits (209), Expect = 1e-16
Identities = 50/165 (30%), Positives = 79/165 (47%), Gaps = 9/165 (5%)
Query: 218 SMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQE-ISAAHSYNP 276
S+ Y + WF +A P G ++ L+ VGGY S++ +S YN
Sbjct: 420 SVEAYNIKSNEWFHVA----PMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNA 475
Query: 277 STNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQ----AVSNVECYNPEQDAWNFVAPLPN 332
+TNEW +A M+ +RS + +N+ LYA+GG +VE Y+P +AW VA +
Sbjct: 476 TTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNM 535
Query: 333 PLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETC 377
C G +YV+GG ++ Y P++D WT+ +C
Sbjct: 536 CRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSC 580
Score = 78.6 bits (192), Expect = 1e-14
Identities = 72/276 (26%), Positives = 112/276 (40%), Gaps = 29/276 (10%)
Query: 214 GEPPSMLR----YEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEIS 269
G+ P +R Y+ ERW +A LP G + +F VGG+ S +
Sbjct: 318 GQAPKAIRSVECYDFKEERWHQVAE-LPSRRCRA---GMVYMAGLVFAVGGFN-GSLRVR 372
Query: 270 AAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWN 325
SY+P ++W VA+M +RS +N LYA+GG +S+VE YN + + W
Sbjct: 373 TVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWF 432
Query: 326 FVAPLPNPLAEFSACECKGKIYVIGGYTTRDRN--MNILQYCPSSDMWTLFETCDVHIRK 383
VAP+ + G +Y +GGY R + Y +++ WT
Sbjct: 433 HVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSG 492
Query: 384 QQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLT 443
+ + +Y VGG H+ GP R S V+ Y+ T W + +
Sbjct: 493 AGVGVLNNLLYAVGG--HD-GPLVRKS-------VEVYDPTTNAWRQVADMNMCRRNAGV 542
Query: 444 CALHNDGIYIMSRDVTLSTSLEHRVFLKYNIFSDSW 479
CA+ N +Y++ D S YN +D W
Sbjct: 543 CAV-NGLLYVVGGD---DGSCNLASVEYYNPTTDKW 574
Score = 55.8 bits (133), Expect = 9e-08
Identities = 93/450 (20%), Positives = 171/450 (38%), Gaps = 79/450 (17%)
Query: 7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVL 66
V I ED + L S YF A++ M E+ ++ ++++ G + LR+++
Sbjct: 62 VTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV---RIKEVDGWT---LRMLI 115
Query: 67 DFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSL----LQLLL 122
D++ + EE +V L+ AA LQ+ + + L
Sbjct: 116 DYVYTAE----------------IQVTEENVQV-----LLPAAGLLQLQDVKKTCCEFLE 154
Query: 123 SQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVSLK 182
SQ+ NCL + A ++ DL + HF +V+ +F LG S K
Sbjct: 155 SQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDK 214
Query: 183 QRLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLVN 242
+ V+ + H M R E PL LP + +
Sbjct: 215 LTISSEEKVFEAVIAWVN---------HDKDVRQEFMARLMEHVR--LPL---LPREYLV 260
Query: 243 VRGYGSAILDN------YLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKL 296
R A++ N YL Y + P+ L + + R+ L
Sbjct: 261 QRVEEEALVKNSSACKDYLIEAMKYHLL-----------PTEQRILMKSVRTRLRTPMNL 309
Query: 297 VAVNSKLYAIGGQA---VSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYT 353
+ + +GGQA + +VECY+ +++ W+ VA LP+ G ++ +GG+
Sbjct: 310 PKL---MVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFN 366
Query: 354 TRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSE 413
R + Y P D WT ++ R+ + + ++ G L+ +G S
Sbjct: 367 GSLRVRTVDSYDPVKDQWT--SVANMRDRRSTLGAA-----VLNGLLYAVG---GFDGST 416
Query: 414 DMLTVQSYNTVTRQWLYLKE-NTSKSGLNL 442
+ +V++YN + +W ++ NT +S + +
Sbjct: 417 GLSSVEAYNIKSNEWFHVAPMNTRRSSVGV 446
Score = 30.0 bits (66), Expect = 5.1
Identities = 22/83 (26%), Positives = 40/83 (48%), Gaps = 9/83 (10%)
Query: 222 YEEMTERWFPLANNLPPDLVNV--RGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTN 279
Y+ T W +A+ +N+ R G ++ L++VGG S +++ YNP+T+
Sbjct: 520 YDPTTNAWRQVAD------MNMCRRNAGVCAVNGLLYVVGGDD-GSCNLASVEYYNPTTD 572
Query: 280 EWLQVASMNQKRSNFKLVAVNSK 302
+W V+S ++ V V K
Sbjct: 573 KWTVVSSCMSTGRSYAGVTVIDK 595
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 90.5 bits (223), Expect = 3e-18
Identities = 57/213 (26%), Positives = 100/213 (46%), Gaps = 21/213 (9%)
Query: 222 YEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEW 281
Y+ + ++W +AN G+A+L+ L+ VGG+ S +S+ +YN +NEW
Sbjct: 373 YDPVKDQWTSVANMRDRRST----LGAAVLNGLLYAVGGFD-GSTGLSSVEAYNIKSNEW 427
Query: 282 LQVASMNQKRSNFKLVAVNSKLYAIGG------QAVSNVECYNPEQDAWNFVAPLPNPLA 335
VA MN +RS+ + V LYA+GG Q +S VECYN + W ++A + +
Sbjct: 428 FHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRS 487
Query: 336 EFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYI 395
+Y +GG+ ++ Y P+++ W ++ R + +V +Y+
Sbjct: 488 GAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYV 547
Query: 396 VGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQW 428
VGG S ++ +V+ YN T +W
Sbjct: 548 VGG----------DDGSCNLASVEYYNPTTDKW 570
Score = 85.1 bits (209), Expect = 1e-16
Identities = 50/165 (30%), Positives = 79/165 (47%), Gaps = 9/165 (5%)
Query: 218 SMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQE-ISAAHSYNP 276
S+ Y + WF +A P G ++ L+ VGGY S++ +S YN
Sbjct: 416 SVEAYNIKSNEWFHVA----PMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNA 471
Query: 277 STNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQ----AVSNVECYNPEQDAWNFVAPLPN 332
+TNEW +A M+ +RS + +N+ LYA+GG +VE Y+P +AW VA +
Sbjct: 472 TTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNM 531
Query: 333 PLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETC 377
C G +YV+GG ++ Y P++D WT+ +C
Sbjct: 532 CRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSC 576
Score = 78.6 bits (192), Expect = 1e-14
Identities = 72/276 (26%), Positives = 112/276 (40%), Gaps = 29/276 (10%)
Query: 214 GEPPSMLR----YEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEIS 269
G+ P +R Y+ ERW +A LP G + +F VGG+ S +
Sbjct: 314 GQAPKAIRSVECYDFKEERWHQVAE-LPSRRCRA---GMVYMAGLVFAVGGFN-GSLRVR 368
Query: 270 AAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWN 325
SY+P ++W VA+M +RS +N LYA+GG +S+VE YN + + W
Sbjct: 369 TVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWF 428
Query: 326 FVAPLPNPLAEFSACECKGKIYVIGGYTTRDRN--MNILQYCPSSDMWTLFETCDVHIRK 383
VAP+ + G +Y +GGY R + Y +++ WT
Sbjct: 429 HVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSG 488
Query: 384 QQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLT 443
+ + +Y VGG H+ GP R S V+ Y+ T W + +
Sbjct: 489 AGVGVLNNLLYAVGG--HD-GPLVRKS-------VEVYDPTTNAWRQVADMNMCRRNAGV 538
Query: 444 CALHNDGIYIMSRDVTLSTSLEHRVFLKYNIFSDSW 479
CA+ N +Y++ D S YN +D W
Sbjct: 539 CAV-NGLLYVVGGD---DGSCNLASVEYYNPTTDKW 570
Score = 55.8 bits (133), Expect = 9e-08
Identities = 93/450 (20%), Positives = 171/450 (38%), Gaps = 79/450 (17%)
Query: 7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVL 66
V I ED + L S YF A++ M E+ ++ ++++ G + LR+++
Sbjct: 58 VTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV---RIKEVDGWT---LRMLI 111
Query: 67 DFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSL----LQLLL 122
D++ + EE +V L+ AA LQ+ + + L
Sbjct: 112 DYVYTAE----------------IQVTEENVQV-----LLPAAGLLQLQDVKKTCCEFLE 150
Query: 123 SQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVSLK 182
SQ+ NCL + A ++ DL + HF +V+ +F LG S K
Sbjct: 151 SQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDK 210
Query: 183 QRLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLVN 242
+ V+ + H M R E PL LP + +
Sbjct: 211 LTISSEEKVFEAVIAWVN---------HDKDVRQEFMARLMEHVR--LPL---LPREYLV 256
Query: 243 VRGYGSAILDN------YLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKL 296
R A++ N YL Y + P+ L + + R+ L
Sbjct: 257 QRVEEEALVKNSSACKDYLIEAMKYHLL-----------PTEQRILMKSVRTRLRTPMNL 305
Query: 297 VAVNSKLYAIGGQA---VSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYT 353
+ + +GGQA + +VECY+ +++ W+ VA LP+ G ++ +GG+
Sbjct: 306 PKL---MVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFN 362
Query: 354 TRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSE 413
R + Y P D WT ++ R+ + + ++ G L+ +G S
Sbjct: 363 GSLRVRTVDSYDPVKDQWT--SVANMRDRRSTLGAA-----VLNGLLYAVG---GFDGST 412
Query: 414 DMLTVQSYNTVTRQWLYLKE-NTSKSGLNL 442
+ +V++YN + +W ++ NT +S + +
Sbjct: 413 GLSSVEAYNIKSNEWFHVAPMNTRRSSVGV 442
Score = 30.0 bits (66), Expect = 5.1
Identities = 22/83 (26%), Positives = 40/83 (48%), Gaps = 9/83 (10%)
Query: 222 YEEMTERWFPLANNLPPDLVNV--RGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTN 279
Y+ T W +A+ +N+ R G ++ L++VGG S +++ YNP+T+
Sbjct: 516 YDPTTNAWRQVAD------MNMCRRNAGVCAVNGLLYVVGGDD-GSCNLASVEYYNPTTD 568
Query: 280 EWLQVASMNQKRSNFKLVAVNSK 302
+W V+S ++ V V K
Sbjct: 569 KWTVVSSCMSTGRSYAGVTVIDK 591
>gi|88196794 kelch-like 35 [Homo sapiens]
Length = 363
Score = 90.5 bits (223), Expect = 3e-18
Identities = 56/187 (29%), Positives = 100/187 (53%), Gaps = 12/187 (6%)
Query: 222 YEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEW 281
Y ++RW PL + LP + + L N +++ GG+ I S ++ S+ + W
Sbjct: 102 YHPESQRWTPLPS-LPG--YTRSEFAACALRNDVYVSGGH-INSHDVWMFSSH---LHTW 154
Query: 282 LQVASMNQKRSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWNFVAPLPNPLAEF 337
++VAS+++ R K+ V +L+A+GG + + +VE Y+P + W APLP ++
Sbjct: 155 IKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSA 214
Query: 338 SACECKGKIYVIGGYTTRDRNMNILQ-YCPSSDMWTLFETCDVHIRKQQMVSVEETIYIV 396
+ C GK++VIGG N + +Q + P D W+L R + VS+E+TIY++
Sbjct: 215 AVASCAGKLFVIGGARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVM 274
Query: 397 GGCLHEL 403
GG + ++
Sbjct: 275 GGLMSKI 281
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/152 (24%), Positives = 67/152 (44%), Gaps = 6/152 (3%)
Query: 218 SMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPS 277
S+ RY+ + W A P+ V+ S LF++GG R ++P
Sbjct: 190 SVERYDPFSNTWAAAAPL--PEAVSSAAVASCA--GKLFVIGGARQGGVNTDKVQCFDPK 245
Query: 278 TNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSNVECYNPEQDAWNFVAPLPNPLAEF 337
+ W + + + V++ +Y +GG +S + Y+P D W A LP+P+
Sbjct: 246 EDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG-LMSKIFTYDPGTDVWGEAAVLPSPVESC 304
Query: 338 SACECKGKIYVIGGYTTRDRNMN-ILQYCPSS 368
C GK++++GG R + + + + PSS
Sbjct: 305 GVTVCDGKVHILGGRDDRGESTDKVFTFDPSS 336
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 89.0 bits (219), Expect = 9e-18
Identities = 55/163 (33%), Positives = 85/163 (52%), Gaps = 9/163 (5%)
Query: 246 YGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYA 305
+ L N ++I GG + T ++ YN S N+W+Q+ +N R K+V + K+Y
Sbjct: 370 FACVTLKNEVYISGG-KETQHDV---WKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYV 425
Query: 306 IGG----QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNI 361
IGG Q ++NVE Y+P + W+ APL ++ F+A K K+YVIGG +
Sbjct: 426 IGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDK 485
Query: 362 LQ-YCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHEL 403
Q Y PS++ W+L V + VS + IY+VGG + L
Sbjct: 486 TQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRAL 528
Score = 60.8 bits (146), Expect = 3e-09
Identities = 37/142 (26%), Positives = 63/142 (44%), Gaps = 6/142 (4%)
Query: 238 PDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLV 297
P LV+V + + L+++GG Y+PSTN+W A+M + V
Sbjct: 453 PLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAV 512
Query: 298 AVNSKLYAIGGQAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDR 357
+ ++Y +GG A+ + Y+P +D+W V L + A C ++Y+ GG RD
Sbjct: 513 SFRDRIYVVGG-AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGG---RDE 568
Query: 358 NMNILQ--YCPSSDMWTLFETC 377
++ C + L E C
Sbjct: 569 KNEVIATVLCWDPEAQKLTEEC 590
Score = 60.5 bits (145), Expect = 4e-09
Identities = 104/501 (20%), Positives = 183/501 (36%), Gaps = 96/501 (19%)
Query: 23 LIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVLDFINAGGAREGWLLGP 82
L S+YFRA++ + ++E + ++G+ A + +LD+ A
Sbjct: 90 LAAASNYFRAMFCNDLKEKYEKRI------IIKGVDAETMHTLLDYTYTSKA-------- 135
Query: 83 RGEKGGGVDEDEEMDEVSLLSELVEAASFLQ----VTSLLQLLLSQVRLNNCLEMYRLAQ 138
+ + ++EAA+ Q V + L + NC+ + RLA
Sbjct: 136 -------------LITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLAD 182
Query: 139 VYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVSLKQRL---REARMTGTPV 195
+ L L++ +++ +F ++L +F L P + L EA++ T V
Sbjct: 183 THSLDSLKKQVQSYIIQNFVQILNSEEF--LDLPVDTLHHILKSDDLYVTEEAQVFET-V 239
Query: 196 LVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWF--------PLANNLP---PDLVNVR 244
+ + L PY E + + + W+ PL P P L R
Sbjct: 240 MSWVRHKPSERLCLLPYVLENVRL----PLLDPWYFVETVEADPLIRQCPEVFPLLQEAR 295
Query: 245 GY---GSAIL------------DNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVA---- 285
Y G+ I+ I+GG + ++ +P L+VA
Sbjct: 296 MYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPL 355
Query: 286 ------SMNQKRSNFKLVAVNSKLYAIGGQAVS-NVECYNPEQDAWNFVAPLPNPLAEFS 338
S N+K F V + +++Y GG+ +V YN + W + L
Sbjct: 356 TEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHK 415
Query: 339 ACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGG 398
GK+YVIGG+ R N+ Y P + W+ VH+ S ++ +Y++GG
Sbjct: 416 MVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGG 475
Query: 399 CLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDV 458
GPN + + + Q Y+ T +W LK + D IY++ +
Sbjct: 476 -----GPNGKLATDK----TQCYDPSTNKW-SLKAAMPVEAKCINAVSFRDRIYVVGGAM 525
Query: 459 TLSTSLEHRVFLKYNIFSDSW 479
R Y+ DSW
Sbjct: 526 --------RALYAYSPLEDSW 538
>gi|24475847 influenza virus NS1A binding protein [Homo sapiens]
Length = 642
Score = 88.2 bits (217), Expect = 2e-17
Identities = 65/277 (23%), Positives = 114/277 (41%), Gaps = 32/277 (11%)
Query: 222 YEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEW 281
Y T+ W LA P + A+L L++VGG S ++S Y+ + ++W
Sbjct: 388 YNPHTDHWSFLAPMRTPRA----RFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDW 443
Query: 282 LQVASMNQKRSNFKLVAVNSKLYAIGG------QAVSNVECYNPEQDAWNFVAPLPNPLA 335
+ V + R N + A+N KLY +GG + + N + ++P W APL
Sbjct: 444 IPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRH 503
Query: 336 EFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYI 395
+ + CE G +Y+IGG + + + +Y P ++ WTL +V R + + +++
Sbjct: 504 QSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFV 563
Query: 396 VGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMS 455
GG S + V+ Y+ +W K N+T N GI +
Sbjct: 564 CGG----------FDGSHAISCVEMYDPTRNEW--------KMMGNMTSPRSNAGIATVG 605
Query: 456 RDVTLSTSLEHRVFLK----YNIFSDSWEAFRRFPAF 488
+ + FL YN+ S+ W + + F
Sbjct: 606 NTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKIFQF 642
Score = 64.3 bits (155), Expect = 2e-10
Identities = 39/142 (27%), Positives = 69/142 (48%), Gaps = 7/142 (4%)
Query: 264 TSQEISAAHSYNPSTNEWLQ--VASMNQKRSNFKLVAVNSKLYAIGG----QAVSNVECY 317
++ ++S + S+ +E ++ ++ M RS +N KL A GG + + VECY
Sbjct: 329 STPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECY 388
Query: 318 NPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQ-YCPSSDMWTLFET 376
NP D W+F+AP+ P A F G++YV+GG +++ + Y + D W
Sbjct: 389 NPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPE 448
Query: 377 CDVHIRKQQMVSVEETIYIVGG 398
+ + ++ +YIVGG
Sbjct: 449 LRTNRCNAGVCALNGKLYIVGG 470
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 87.8 bits (216), Expect = 2e-17
Identities = 102/491 (20%), Positives = 189/491 (38%), Gaps = 78/491 (15%)
Query: 27 SDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVLDFINAGGAREGWLLGPRGEK 86
SDYF A++ + +REA +E ++ G+ L ++ + G
Sbjct: 181 SDYFAAMFTNDVREARQEEI------KMEGVEPNSLWSLIQYAYTGRLE----------- 223
Query: 87 GGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQ----LLLSQVRLNNCLEMYRLAQVYGL 142
+ ED + L+ A LQ++ +++ L+ Q+ +NCL + A G
Sbjct: 224 ---LKEDN-------IECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGC 273
Query: 143 PDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQA----------PGDVSLKQRLR------ 186
DL + + + HF EV+ +F LL + A P + ++ L
Sbjct: 274 TDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHD 333
Query: 187 -EARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEE--------MTERWFPLANNLP 237
E R L+A ++ PL + + + + + + M + L
Sbjct: 334 LEQRRKDLSKLLA---YIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERR 390
Query: 238 PDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLV 297
P L + R LF VGG T S Y+ TN W VA+MN +R F +
Sbjct: 391 PMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSI-EKYDLRTNMWTPVANMNGRRLQFGVA 449
Query: 298 AVNSKLYAIGGQ----AVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYT 353
++ KLY +GG+ ++ VECYNP+ W+ + P+ +G +Y +GG+
Sbjct: 450 VLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD 509
Query: 354 TRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSE 413
+ ++ P + W T + + +Y VGG S
Sbjct: 510 GWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG----------RDGSS 559
Query: 414 DMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVTLSTSLEHRV---FL 470
+ +V+ ++ T +W + + + G + N +Y + +++L R+
Sbjct: 560 CLKSVECFDPHTNKWTLCAQMSKRRG-GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVE 618
Query: 471 KYNIFSDSWEA 481
+Y+ +D W A
Sbjct: 619 RYDPKTDMWTA 629
Score = 84.0 bits (206), Expect = 3e-16
Identities = 54/217 (24%), Positives = 98/217 (45%), Gaps = 25/217 (11%)
Query: 222 YEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEW 281
Y T+ W + +PP + G G A+L+ ++ VGG+ S ++ ++P +W
Sbjct: 473 YNPKTKTW----SVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSY-LNTVERWDPQARQW 527
Query: 282 LQVASMNQKRSNFKLVAVNSKLYAIGGQ----AVSNVECYNPEQDAWNFVAPLPNPLAEF 337
VA+M+ RS + ++ KLYA+GG+ + +VEC++P + W A +
Sbjct: 528 NFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGV 587
Query: 338 SACECKGKIYVIGGYTTRDRNMN------ILQYCPSSDMWTLFETCDVHIRKQQMVSVEE 391
G +Y IGG+ N+ + +Y P +DMWT + + + + +
Sbjct: 588 GVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGD 647
Query: 392 TIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQW 428
+Y VGG + N TV++Y+ T +W
Sbjct: 648 KLYAVGGYDGQAYLN----------TVEAYDPQTNEW 674
Score = 71.6 bits (174), Expect = 2e-12
Identities = 51/164 (31%), Positives = 72/164 (43%), Gaps = 14/164 (8%)
Query: 222 YEEMTERWFPLAN--NLPPDLVNVRG-YGSAILDNYLFIVGGYRITSQEISAAHSYNPST 278
Y ERW P A N + R G A+L L+ VGG R S + + ++P T
Sbjct: 513 YLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG-RDGSSCLKSVECFDPHT 571
Query: 279 NEWLQVASMNQKRSNFKLVAVNSKLYAIGGQ--AVSN--------VECYNPEQDAWNFVA 328
N+W A M+++R + N LYAIGG SN VE Y+P+ D W VA
Sbjct: 572 NKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVA 631
Query: 329 PLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWT 372
+ C K+Y +GGY + + Y P ++ WT
Sbjct: 632 SMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWT 675
Score = 56.6 bits (135), Expect = 5e-08
Identities = 34/95 (35%), Positives = 49/95 (51%), Gaps = 9/95 (9%)
Query: 245 GYGSAILDNYLFIVGGY-----RITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAV 299
G G + L+ +GG+ +TS+ Y+P T+ W VASM+ R + +
Sbjct: 586 GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLL 645
Query: 300 NSKLYAIGG---QAVSN-VECYNPEQDAWNFVAPL 330
KLYA+GG QA N VE Y+P+ + W VAPL
Sbjct: 646 GDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 680
Score = 40.4 bits (93), Expect = 0.004
Identities = 26/80 (32%), Positives = 43/80 (53%), Gaps = 7/80 (8%)
Query: 221 RYEEMTERWFPLAN-NLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTN 279
RY+ T+ W +A+ ++ D V V +L + L+ VGGY + ++ +Y+P TN
Sbjct: 619 RYDPKTDMWTAVASMSISRDAVGV-----CLLGDKLYAVGGYDGQAY-LNTVEAYDPQTN 672
Query: 280 EWLQVASMNQKRSNFKLVAV 299
EW QVA + R+ +V V
Sbjct: 673 EWTQVAPLCLGRAGACVVTV 692
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 87.4 bits (215), Expect = 3e-17
Identities = 59/229 (25%), Positives = 104/229 (45%), Gaps = 26/229 (11%)
Query: 222 YEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEW 281
Y T+ W LPP + G G +L+ ++ VGG+ S ++ ++P + +W
Sbjct: 526 YNPKTKTW----TVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSY-LNTVERWDPQSQQW 580
Query: 282 LQVASMNQKRSNFKLVAVNSKLYAIGGQ----AVSNVECYNPEQDAWNFVAPLPNPLAEF 337
VASM+ RS + A+N KLY++GG+ +S++E Y+P + WN AP+
Sbjct: 581 TFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGV 640
Query: 338 SACECKGKIYVIGGYTTRDRNM------NILQYCPSSDMWTLFETCDVHIRKQQMVSVEE 391
C G +Y +GG+ N + +Y P +D WT+ + + + +
Sbjct: 641 GVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGD 700
Query: 392 TIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKE-NTSKSG 439
+Y VGG + N T++SY+ T +W + N ++G
Sbjct: 701 RLYAVGGYDGQTYLN----------TMESYDPQTNEWTQMASLNIGRAG 739
Score = 77.0 bits (188), Expect = 4e-14
Identities = 89/422 (21%), Positives = 161/422 (38%), Gaps = 70/422 (16%)
Query: 13 DRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVLDFINAG 72
+R P + L SDYF A++ S + EA +E ++ G+ L ++ F G
Sbjct: 220 NRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEI------KMEGIDPNALWDLVQFAYTG 273
Query: 73 GAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQL----LLSQVRLN 128
+ ED + L+ AA LQ+ ++++ L+ + +
Sbjct: 274 CLE--------------LKEDT-------IENLLAAACLLQLPQVVEVCCHFLMKLLHPS 312
Query: 129 NCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPP----------QAPGD 178
NCL + A G +L + + + + EV+ +F LL + P +
Sbjct: 313 NCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDE 372
Query: 179 VSLKQRLR-------EARMTGTPVLVALGDFLGGPLAPHPYQGEPPS-----------ML 220
++ L ++R +L+A F+ PL P + + L
Sbjct: 373 ETIFHALMMWVKYDMQSRCNDLSMLLA---FIRLPLLPPQILADLENHALFKNDLECQKL 429
Query: 221 RYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNE 280
E M P L + + R L+ VGG ++ + Y+ TN
Sbjct: 430 ILEAMKYHLLPERRTL---MQSPRTKPRKSTVGTLYAVGGMD-NNKGATTIEKYDLRTNL 485
Query: 281 WLQVASMNQKRSNFKLVAVNSKLYAIGGQ----AVSNVECYNPEQDAWNFVAPLPNPLAE 336
W+Q MN +R F + ++ KL+ IGG+ ++ VECYNP+ W + P+
Sbjct: 486 WIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHG 545
Query: 337 FSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIV 396
+G IY +GG+ + ++ P S WT + + + ++ +Y V
Sbjct: 546 LGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSV 605
Query: 397 GG 398
GG
Sbjct: 606 GG 607
Score = 72.0 bits (175), Expect = 1e-12
Identities = 48/190 (25%), Positives = 87/190 (45%), Gaps = 15/190 (7%)
Query: 246 YGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYA 305
+G A++D+ LF++GG R + ++ YNP T W + M+ R + + +YA
Sbjct: 499 FGVAVIDDKLFVIGG-RDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYA 557
Query: 306 IGGQA----VSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNI 361
+GG ++ VE ++P+ W FVA + + GK+Y +GG ++
Sbjct: 558 VGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSM 617
Query: 362 LQYCPSSDMWTLFETCDVHIRKQQMVSV---EETIYIVGGCLHELGPNRRSSQSEDMLTV 418
Y P ++ W + C +++ V V + +Y VGG H+ + S+ D V
Sbjct: 618 EYYDPHTNKWNM---CAPMCKRRGGVGVATCDGFLYAVGG--HDAPASNHCSRLLDY--V 670
Query: 419 QSYNTVTRQW 428
+ Y+ T W
Sbjct: 671 ERYDPKTDTW 680
Score = 46.2 bits (108), Expect = 7e-05
Identities = 28/80 (35%), Positives = 45/80 (56%), Gaps = 7/80 (8%)
Query: 221 RYEEMTERWFPLAN-NLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTN 279
RY+ T+ W +A ++P D V V +L + L+ VGGY + ++ SY+P TN
Sbjct: 672 RYDPKTDTWTMVAPLSMPRDAVGV-----CLLGDRLYAVGGYDGQTY-LNTMESYDPQTN 725
Query: 280 EWLQVASMNQKRSNFKLVAV 299
EW Q+AS+N R+ +V +
Sbjct: 726 EWTQMASLNIGRAGACVVVI 745
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 87.4 bits (215), Expect = 3e-17
Identities = 51/159 (32%), Positives = 85/159 (53%), Gaps = 9/159 (5%)
Query: 218 SMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPS 277
S+ RYE + W +A P L G G A+L+ L+ VGG+ T++ +++A Y P
Sbjct: 439 SVERYEPERDEWHLVA----PMLTRRIGVGVAVLNRLLYAVGGFDGTNR-LNSAECYYPE 493
Query: 278 TNEWLQVASMNQKRSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWNFVAPLPNP 333
NEW + +MN RS + +++ +YA GG +++VE Y+ E + W FVAP+ +
Sbjct: 494 RNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHR 553
Query: 334 LAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWT 372
+ +G+IYV+GGY ++ Y P +D W+
Sbjct: 554 RSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWS 592
Score = 74.3 bits (181), Expect = 2e-13
Identities = 56/241 (23%), Positives = 98/241 (40%), Gaps = 24/241 (9%)
Query: 222 YEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRIT---SQEISAAHSYNPST 278
Y W LA+ P G ++ L+ VGG + + + SA YNP T
Sbjct: 345 YNPSDGTWLRLADLQVPR----SGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMT 400
Query: 279 NEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAV----SNVECYNPEQDAWNFVAPLPNPL 334
N+W A M+ R+ + ++ +YA+GG ++VE Y PE+D W+ VAP+
Sbjct: 401 NQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRR 460
Query: 335 AEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIY 394
+Y +GG+ +R + Y P + W + + + + IY
Sbjct: 461 IGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIY 520
Query: 395 IVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKE-NTSKSGLNLTCALHNDGIYI 453
GG + + +V+ Y+ T W ++ +S L +T +H IY+
Sbjct: 521 AAGG----------YDGQDQLNSVERYDVETETWTFVAPMKHRRSALGIT--VHQGRIYV 568
Query: 454 M 454
+
Sbjct: 569 L 569
Score = 73.9 bits (180), Expect = 3e-13
Identities = 57/203 (28%), Positives = 85/203 (41%), Gaps = 22/203 (10%)
Query: 255 LFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQA---- 310
++ GGY Q +S +YNPS WL++A + RS V LYA+GG+
Sbjct: 328 IYTAGGY--FRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPD 385
Query: 311 ----VSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCP 366
S ++CYNP + W+ AP+ P G IY +GG + ++ +Y P
Sbjct: 386 GNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEP 445
Query: 367 SSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTR 426
D W L + + +Y VGG G NR +S + Y
Sbjct: 446 ERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGF---DGTNRLNS-------AECYYPERN 495
Query: 427 QW-LYLKENTSKSGLNLTCALHN 448
+W + NT +SG + C LHN
Sbjct: 496 EWRMITAMNTIRSGAGV-CVLHN 517
Score = 53.5 bits (127), Expect = 4e-07
Identities = 27/87 (31%), Positives = 44/87 (50%), Gaps = 5/87 (5%)
Query: 245 GYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLY 304
G G +L N ++ GGY Q +++ Y+ T W VA M +RS + ++Y
Sbjct: 509 GAGVCVLHNCIYAAGGYDGQDQ-LNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIY 567
Query: 305 AIGGQA----VSNVECYNPEQDAWNFV 327
+GG + +VECY+P+ D W+ V
Sbjct: 568 VLGGYDGHTFLDSVECYDPDTDTWSEV 594
Score = 30.8 bits (68), Expect = 3.0
Identities = 21/80 (26%), Positives = 35/80 (43%), Gaps = 5/80 (6%)
Query: 213 QGEPPSMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAH 272
Q + S+ RY+ TE W +A P G + ++++GGY + +
Sbjct: 528 QDQLNSVERYDVETETWTFVA----PMKHRRSALGITVHQGRIYVLGGYD-GHTFLDSVE 582
Query: 273 SYNPSTNEWLQVASMNQKRS 292
Y+P T+ W +V M RS
Sbjct: 583 CYDPDTDTWSEVTRMTSGRS 602
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 87.4 bits (215), Expect = 3e-17
Identities = 51/159 (32%), Positives = 85/159 (53%), Gaps = 9/159 (5%)
Query: 218 SMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPS 277
S+ RYE + W +A P L G G A+L+ L+ VGG+ T++ +++A Y P
Sbjct: 439 SVERYEPERDEWHLVA----PMLTRRIGVGVAVLNRLLYAVGGFDGTNR-LNSAECYYPE 493
Query: 278 TNEWLQVASMNQKRSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWNFVAPLPNP 333
NEW + +MN RS + +++ +YA GG +++VE Y+ E + W FVAP+ +
Sbjct: 494 RNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHR 553
Query: 334 LAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWT 372
+ +G+IYV+GGY ++ Y P +D W+
Sbjct: 554 RSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWS 592
Score = 74.3 bits (181), Expect = 2e-13
Identities = 56/241 (23%), Positives = 98/241 (40%), Gaps = 24/241 (9%)
Query: 222 YEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRIT---SQEISAAHSYNPST 278
Y W LA+ P G ++ L+ VGG + + + SA YNP T
Sbjct: 345 YNPSDGTWLRLADLQVPR----SGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMT 400
Query: 279 NEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAV----SNVECYNPEQDAWNFVAPLPNPL 334
N+W A M+ R+ + ++ +YA+GG ++VE Y PE+D W+ VAP+
Sbjct: 401 NQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRR 460
Query: 335 AEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIY 394
+Y +GG+ +R + Y P + W + + + + IY
Sbjct: 461 IGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIY 520
Query: 395 IVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKE-NTSKSGLNLTCALHNDGIYI 453
GG + + +V+ Y+ T W ++ +S L +T +H IY+
Sbjct: 521 AAGG----------YDGQDQLNSVERYDVETETWTFVAPMKHRRSALGIT--VHQGRIYV 568
Query: 454 M 454
+
Sbjct: 569 L 569
Score = 73.9 bits (180), Expect = 3e-13
Identities = 57/203 (28%), Positives = 85/203 (41%), Gaps = 22/203 (10%)
Query: 255 LFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQA---- 310
++ GGY Q +S +YNPS WL++A + RS V LYA+GG+
Sbjct: 328 IYTAGGY--FRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPD 385
Query: 311 ----VSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCP 366
S ++CYNP + W+ AP+ P G IY +GG + ++ +Y P
Sbjct: 386 GNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEP 445
Query: 367 SSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTR 426
D W L + + +Y VGG G NR +S + Y
Sbjct: 446 ERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGF---DGTNRLNS-------AECYYPERN 495
Query: 427 QW-LYLKENTSKSGLNLTCALHN 448
+W + NT +SG + C LHN
Sbjct: 496 EWRMITAMNTIRSGAGV-CVLHN 517
Score = 53.5 bits (127), Expect = 4e-07
Identities = 27/87 (31%), Positives = 44/87 (50%), Gaps = 5/87 (5%)
Query: 245 GYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLY 304
G G +L N ++ GGY Q +++ Y+ T W VA M +RS + ++Y
Sbjct: 509 GAGVCVLHNCIYAAGGYDGQDQ-LNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIY 567
Query: 305 AIGGQA----VSNVECYNPEQDAWNFV 327
+GG + +VECY+P+ D W+ V
Sbjct: 568 VLGGYDGHTFLDSVECYDPDTDTWSEV 594
Score = 30.8 bits (68), Expect = 3.0
Identities = 21/80 (26%), Positives = 35/80 (43%), Gaps = 5/80 (6%)
Query: 213 QGEPPSMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAH 272
Q + S+ RY+ TE W +A P G + ++++GGY + +
Sbjct: 528 QDQLNSVERYDVETETWTFVA----PMKHRRSALGITVHQGRIYVLGGYD-GHTFLDSVE 582
Query: 273 SYNPSTNEWLQVASMNQKRS 292
Y+P T+ W +V M RS
Sbjct: 583 CYDPDTDTWSEVTRMTSGRS 602
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 84.3 bits (207), Expect = 2e-16
Identities = 95/433 (21%), Positives = 159/433 (36%), Gaps = 76/433 (17%)
Query: 7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVL 66
V +++ D + + L YF A++ + M E E ++G+ L ++
Sbjct: 40 VTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEI------VMQGMDPSALEALI 93
Query: 67 DFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQ----LLL 122
+F G +D+ + L+ ASFLQ+ S+ L
Sbjct: 94 NFAYNGNL--------------AIDQQN-------VQSLLMGASFLQLQSIKDACCTFLR 132
Query: 123 SQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQF------HLLGSPPQAP 176
++ NCL + + A+ L +A F+ HF EV +F +L +
Sbjct: 133 ERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDE 192
Query: 177 GDVSLKQRLREARMTGT--------PVLVALGDFLGGPLAPHPYQGE---PPSMLR---- 221
+V ++++ EA + P L L + PL + + ++R
Sbjct: 193 LNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHK 252
Query: 222 ----------YEEMTER--WFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEIS 269
Y M ER P P ++ G ++ VGG ++
Sbjct: 253 CRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGL--------IYAVGGLNSAGDSLN 304
Query: 270 AAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQ----AVSNVECYNPEQDAWN 325
++P N W + M RS + VN LYAIGG +S VE YNPE D W
Sbjct: 305 VVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWT 364
Query: 326 FVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQ 385
V + + + G+IYV GGY ++ Y P +D WT+ + +
Sbjct: 365 RVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAG 424
Query: 386 MVSVEETIYIVGG 398
+ E IY+ GG
Sbjct: 425 VTVFEGRIYVSGG 437
Score = 75.9 bits (185), Expect = 8e-14
Identities = 54/209 (25%), Positives = 96/209 (45%), Gaps = 26/209 (12%)
Query: 247 GSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAI 306
G A+++ L+ +GGY +S +YNP T+ W +V SMN KRS V ++ ++Y
Sbjct: 330 GVAVVNGLLYAIGGYD-GQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVC 388
Query: 307 GG----QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNIL 362
GG ++S+VE Y+PE D W V + + + +G+IYV GG+ ++
Sbjct: 389 GGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVE 448
Query: 363 QYCPSSDMW-----TLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLT 417
Y + W L + C + S+ +++ GG S +
Sbjct: 449 HYNHHTATWHPAAGMLNKRC-----RHGAASLGSKMFVCGG----------YDGSGFLSI 493
Query: 418 VQSYNTVTRQW-LYLKENTSKSGLNLTCA 445
+ Y++V QW L + +T +S ++L +
Sbjct: 494 AEMYSSVADQWCLIVPMHTRRSRVSLVAS 522
Score = 63.2 bits (152), Expect = 5e-10
Identities = 40/167 (23%), Positives = 68/167 (40%), Gaps = 9/167 (5%)
Query: 218 SMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPS 277
S+ Y T++W + + N G + + +++ GG+ Q S+ YN
Sbjct: 399 SVETYSPETDKWTVVTSMSS----NRSAAGVTVFEGRIYVSGGHD-GLQIFSSVEHYNHH 453
Query: 278 TNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQA----VSNVECYNPEQDAWNFVAPLPNP 333
T W A M KR ++ SK++ GG +S E Y+ D W + P+
Sbjct: 454 TATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTR 513
Query: 334 LAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVH 380
+ S G++Y +GGY + ++ Y P +D WT H
Sbjct: 514 RSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACH 560
Score = 31.2 bits (69), Expect = 2.3
Identities = 28/111 (25%), Positives = 48/111 (43%), Gaps = 12/111 (10%)
Query: 344 GKIYVIGGYTTRDRNMNILQ-YCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHE 402
G IY +GG + ++N+++ + P ++ W E C + V V +V G L+
Sbjct: 288 GLIYAVGGLNSAGDSLNVVEVFDPIANCW---ERCRPMTTARSRVGVA----VVNGLLYA 340
Query: 403 LGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYI 453
+G + + TV++YN T W + SK T L IY+
Sbjct: 341 IGGYDGQLR---LSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQ-IYV 387
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,980,651
Number of Sequences: 37866
Number of extensions: 941019
Number of successful extensions: 3059
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 2199
Number of HSP's gapped (non-prelim): 351
length of query: 505
length of database: 18,247,518
effective HSP length: 107
effective length of query: 398
effective length of database: 14,195,856
effective search space: 5649950688
effective search space used: 5649950688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.