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Search of human proteins with 51702240
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 3 isoform a [Homo sapiens]
(588 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 1207 0.0
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 1153 0.0
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 689 0.0
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 687 0.0
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 417 e-116
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 278 1e-74
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 276 5e-74
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 276 5e-74
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 276 5e-74
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 276 5e-74
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 274 2e-73
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 263 4e-70
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 260 2e-69
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] 207 2e-53
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] 207 2e-53
gi|10190706 CDC-like kinase 4 [Homo sapiens] 204 2e-52
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ... 194 1e-49
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ... 194 1e-49
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [... 192 6e-49
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [... 192 6e-49
gi|47717134 CDC-like kinase 2 [Homo sapiens] 189 5e-48
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ... 188 1e-47
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ... 188 1e-47
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] 187 2e-47
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens] 187 2e-47
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens] 180 4e-45
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 162 1e-39
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 150 2e-36
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ... 143 4e-34
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ... 140 4e-33
>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform a [Homo sapiens]
Length = 588
Score = 1207 bits (3124), Expect = 0.0
Identities = 588/588 (100%), Positives = 588/588 (100%)
Query: 1 MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR 60
MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR
Sbjct: 1 MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR 60
Query: 61 RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS 120
RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS
Sbjct: 61 RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS 120
Query: 121 SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG 180
SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG
Sbjct: 121 SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG 180
Query: 181 VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV 240
VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV
Sbjct: 181 VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV 240
Query: 241 RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK 300
RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK
Sbjct: 241 RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK 300
Query: 301 KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360
KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC
Sbjct: 301 KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC 360
Query: 361 FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC 420
FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC
Sbjct: 361 FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC 420
Query: 421 MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS 480
MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS
Sbjct: 421 MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS 480
Query: 481 KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR 540
KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR
Sbjct: 481 KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR 540
Query: 541 VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS 588
VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS
Sbjct: 541 VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS 588
>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform b [Homo sapiens]
Length = 568
Score = 1153 bits (2983), Expect = 0.0
Identities = 562/565 (99%), Positives = 564/565 (99%)
Query: 24 QRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPRRLNMTTEQFTGDHTQHFLDGGEM 83
+ +LGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPRRLNMTTEQFTGDHTQHFLDGGEM
Sbjct: 4 KEKLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPRRLNMTTEQFTGDHTQHFLDGGEM 63
Query: 84 KVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTP 143
KVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTP
Sbjct: 64 KVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTP 123
Query: 144 EQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRD 203
EQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRD
Sbjct: 124 EQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRD 183
Query: 204 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQ 263
HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQ
Sbjct: 184 HLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQ 243
Query: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 323
DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL
Sbjct: 244 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSL 303
Query: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG 383
DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG
Sbjct: 304 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG 363
Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443
SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI
Sbjct: 364 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 423
Query: 444 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL 503
NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL
Sbjct: 424 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL 483
Query: 504 HWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIAN 563
HWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIAN
Sbjct: 484 HWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIAN 543
Query: 564 KLKANLMSETNGSIPLCSVLPKLIS 588
KLKANLMSETNGSIPLCSVLPKLIS
Sbjct: 544 KLKANLMSETNGSIPLCSVLPKLIS 568
>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 2 isoform 2 [Homo sapiens]
Length = 601
Score = 689 bits (1777), Expect = 0.0
Identities = 345/556 (62%), Positives = 423/556 (76%), Gaps = 21/556 (3%)
Query: 52 NPSEPPPPRRLNMTTEQFTGDHTQHFLDG---------GEMKVEQLFQEFGNRKSN-TIQ 101
+P PP R N T ++H ++ G+++V+QLF++ N+++ T Q
Sbjct: 48 SPIALPPLRASNAAAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQ 107
Query: 102 SDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAP-------KVVPLTPEQALKQYKHHL 154
+G++ K V + D ++ + +S+S K P+TPEQA+KQY L
Sbjct: 108 PNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKL 167
Query: 155 TAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKI 214
TA+E EI +YPEIYF+G NAKKR G+ GGPNNGGYDD G+Y+ VP DH+AYRYEVLK+
Sbjct: 168 TAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKV 227
Query: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHM 274
IGKGSFGQV + YDHK+ Q+VALKMVRNEKRFHRQAAEEIRILEHL+KQDK +MNVIHM
Sbjct: 228 IGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHM 287
Query: 275 LESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHC 334
LE+FTFRNH+CM FELLS++LYELIKKNKFQGFS+ LVRKFA SILQ LDALHKN+IIHC
Sbjct: 288 LENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHC 347
Query: 335 DLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWS 394
DLKPENILLK GRS KVIDFGSSC+E+Q++YTYIQSRFYRAPE+ILG+RY PID+WS
Sbjct: 348 DLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWS 407
Query: 395 FGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSV 454
GCILAELLTG PL PGEDEGDQLACM+ELLGMP KLL+ SKRAK F++SKG PRYC+V
Sbjct: 408 LGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTV 467
Query: 455 TTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPA 514
TT +DG VVL GGRSRRGK RGPP S++WG ALKGCDD LF++FLK+CL WDP+ R+TP
Sbjct: 468 TTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPG 527
Query: 515 QALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLKANL--MSE 572
QALRHPW+ + +P+P T +K S KR+ A + SKLPP A+KL+ NL M++
Sbjct: 528 QALRHPWLRRRLPKP-PTGEKTSVKRITESTGAITSI-SKLPPPSSSASKLRTNLAQMTD 585
Query: 573 TNGSIPLCSVLPKLIS 588
NG+I +VLPKL+S
Sbjct: 586 ANGNIQQRTVLPKLVS 601
>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 1 [Homo sapiens]
Length = 528
Score = 687 bits (1772), Expect = 0.0
Identities = 338/518 (65%), Positives = 411/518 (79%), Gaps = 12/518 (2%)
Query: 81 GEMKVEQLFQEFGNRKSN-TIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAP--- 136
G+++V+QLF++ N+++ T Q +G++ K V + D ++ + +S+S
Sbjct: 13 GQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEG 72
Query: 137 ----KVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDD 192
K P+TPEQA+KQY LTA+E EI +YPEIYF+G NAKKR G+ GGPNNGGYDD
Sbjct: 73 MGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDD 132
Query: 193 ADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE 252
G+Y+ VP DH+AYRYEVLK+IGKGSFGQV + YDHK+ Q+VALKMVRNEKRFHRQAAE
Sbjct: 133 DQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAE 192
Query: 253 EIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLV 312
EIRILEHL+KQDK +MNVIHMLE+FTFRNH+CM FELLS++LYELIKKNKFQGFS+ LV
Sbjct: 193 EIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLV 252
Query: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQS 372
RKFA SILQ LDALHKN+IIHCDLKPENILLK GRS KVIDFGSSC+E+Q++YTYIQS
Sbjct: 253 RKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQS 312
Query: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432
RFYRAPE+ILG+RY PID+WS GCILAELLTG PL PGEDEGDQLACM+ELLGMP KL
Sbjct: 313 RFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKL 372
Query: 433 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492
L+ SKRAK F++SKG PRYC+VTT +DG VVL GGRSRRGK RGPP S++WG ALKGCDD
Sbjct: 373 LDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDD 432
Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLG 552
LF++FLK+CL WDP+ R+TP QALRHPW+ + +P+P T +K S KR+ A +
Sbjct: 433 PLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKP-PTGEKTSVKRITESTGAITSI- 490
Query: 553 SKLPPVVGIANKLKANL--MSETNGSIPLCSVLPKLIS 588
SKLPP A+KL+ NL M++ NG+I +VLPKL+S
Sbjct: 491 SKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS 528
>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 4 [Homo sapiens]
Length = 520
Score = 417 bits (1073), Expect = e-116
Identities = 216/415 (52%), Positives = 283/415 (68%), Gaps = 24/415 (5%)
Query: 124 LNTVKSNSSSKAPKV--VPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGV 181
+ T + K+PK V LT +ALK +K+ L+ YE+ EI+ Y E++F+G AKK
Sbjct: 17 IKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTA 76
Query: 182 IGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR 241
+ +DD G Y+ V DH+AYRYEVL+ IGKGSFGQVA+ DHK + VALK++R
Sbjct: 77 PEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIR 136
Query: 242 NEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK 301
N+KRFH+QA E++ILE L+K+DK + NV+HM + F FRNH C+ FELL I+LYEL+K
Sbjct: 137 NKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKN 196
Query: 302 NKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF 361
N FQGFS+ +VR+F S+L+ L L KIIHCDLKPENI+L G++S KVIDFGSSC+
Sbjct: 197 NNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCY 256
Query: 362 EYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 421
E+QK+YTYIQSRFYR+PE+ILG Y ID+WS GCI AEL TG PLFPGE+E +QLAC+
Sbjct: 257 EHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACI 316
Query: 422 MELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSK 481
ME+LG+PP ++ + R + F +SKG P+ + + RGKKR P SK
Sbjct: 317 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNIT---------------NNRGKKR-YPDSK 360
Query: 482 DWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKS-----VPRPLT 531
D LK D F++FL+RCL W+PS R+TP QAL+H WI +S PRP T
Sbjct: 361 DLTMVLKTYDT-SFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQT 414
>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 2 [Homo sapiens]
Length = 754
Score = 278 bits (711), Expect = 1e-74
Identities = 165/442 (37%), Positives = 244/442 (55%), Gaps = 13/442 (2%)
Query: 105 ISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQA--LKQYKHHLTAYEKLEI 162
ISD + + + S N + + + P PL +K YKH Y +
Sbjct: 48 ISDQQVSALSYSDQIQQPLTNQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKK 107
Query: 163 INYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQ 222
+ + + KK V N GYDD + YI + RYE+ +IGKGSFGQ
Sbjct: 108 RRHQQGQGDDSSHKKERKVY----NDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQ 163
Query: 223 VARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRN 282
V + YD +++VA+K+++N+K F QA E+R+LE + K D ++H+ F FRN
Sbjct: 164 VVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRN 223
Query: 283 HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD--ALHKNKIIHCDLKPEN 340
H+C+ FE+LS +LY+L++ F+G S+ L RKFAQ + +L A + IIHCDLKPEN
Sbjct: 224 HLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPEN 283
Query: 341 ILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILA 400
ILL + RS+ K++DFGSSC Q++Y YIQSRFYR+PE++LG Y ID+WS GCIL
Sbjct: 284 ILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILV 343
Query: 401 ELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADG 460
E+ TG+PLF G +E DQ+ ++E+LG+PP +L+Q+ +A+ F + T+
Sbjct: 344 EMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGK 403
Query: 461 RVVLVGGRSR----RGKKRGPPGSKDWGTALKGCDDYL-FIEFLKRCLHWDPSARLTPAQ 515
R G + G + G PG + G + DYL F + + R L +DP R+ P
Sbjct: 404 REYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYY 463
Query: 516 ALRHPWISKSVPRPLTTIDKVS 537
AL+H + K+ T + VS
Sbjct: 464 ALQHSFFKKTADEGTNTSNSVS 485
>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 5 [Homo sapiens]
Length = 529
Score = 276 bits (705), Expect = 5e-74
Identities = 157/398 (39%), Positives = 230/398 (57%), Gaps = 11/398 (2%)
Query: 147 LKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLA 206
+K YKH Y + + + + KK V N GYDD + YI +
Sbjct: 101 IKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVY----NDGYDDDNYDYIVKNGEKWM 156
Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266
RYE+ +IGKGSFGQV + YD +++VA+K+++N+K F QA E+R+LE + K D
Sbjct: 157 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 216
Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD-- 324
++H+ F FRNH+C+ FE+LS +LY+L++ F+G S+ L RKFAQ + +L
Sbjct: 217 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 276
Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGS 384
A + IIHCDLKPENILL + RS+ K++DFGSSC Q++Y YIQSRFYR+PE++LG
Sbjct: 277 ATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGM 336
Query: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444
Y ID+WS GCIL E+ TG+PLF G +E DQ+ ++E+LG+PP +L+Q+ +A+ F
Sbjct: 337 PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFE 396
Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSR----RGKKRGPPGSKDWGTALKGCDDYL-FIEFL 499
+ T+ R G + G + G PG + G + DYL F + +
Sbjct: 397 KLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLI 456
Query: 500 KRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVS 537
R L +DP R+ P AL+H + K+ T + VS
Sbjct: 457 LRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVS 494
>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 4 [Homo sapiens]
Length = 540
Score = 276 bits (705), Expect = 5e-74
Identities = 157/398 (39%), Positives = 230/398 (57%), Gaps = 11/398 (2%)
Query: 147 LKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLA 206
+K YKH Y + + + + KK V N GYDD + YI +
Sbjct: 101 IKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVY----NDGYDDDNYDYIVKNGEKWM 156
Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266
RYE+ +IGKGSFGQV + YD +++VA+K+++N+K F QA E+R+LE + K D
Sbjct: 157 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 216
Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD-- 324
++H+ F FRNH+C+ FE+LS +LY+L++ F+G S+ L RKFAQ + +L
Sbjct: 217 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 276
Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGS 384
A + IIHCDLKPENILL + RS+ K++DFGSSC Q++Y YIQSRFYR+PE++LG
Sbjct: 277 ATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGM 336
Query: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444
Y ID+WS GCIL E+ TG+PLF G +E DQ+ ++E+LG+PP +L+Q+ +A+ F
Sbjct: 337 PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFE 396
Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSR----RGKKRGPPGSKDWGTALKGCDDYL-FIEFL 499
+ T+ R G + G + G PG + G + DYL F + +
Sbjct: 397 KLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLI 456
Query: 500 KRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVS 537
R L +DP R+ P AL+H + K+ T + VS
Sbjct: 457 LRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVS 494
>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 3 [Homo sapiens]
Length = 584
Score = 276 bits (705), Expect = 5e-74
Identities = 157/398 (39%), Positives = 230/398 (57%), Gaps = 11/398 (2%)
Query: 147 LKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLA 206
+K YKH Y + + + + KK V N GYDD + YI +
Sbjct: 101 IKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVY----NDGYDDDNYDYIVKNGEKWM 156
Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266
RYE+ +IGKGSFGQV + YD +++VA+K+++N+K F QA E+R+LE + K D
Sbjct: 157 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 216
Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD-- 324
++H+ F FRNH+C+ FE+LS +LY+L++ F+G S+ L RKFAQ + +L
Sbjct: 217 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 276
Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGS 384
A + IIHCDLKPENILL + RS+ K++DFGSSC Q++Y YIQSRFYR+PE++LG
Sbjct: 277 ATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGM 336
Query: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444
Y ID+WS GCIL E+ TG+PLF G +E DQ+ ++E+LG+PP +L+Q+ +A+ F
Sbjct: 337 PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFE 396
Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSR----RGKKRGPPGSKDWGTALKGCDDYL-FIEFL 499
+ T+ R G + G + G PG + G + DYL F + +
Sbjct: 397 KLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLI 456
Query: 500 KRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVS 537
R L +DP R+ P AL+H + K+ T + VS
Sbjct: 457 LRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVS 494
>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 1 [Homo sapiens]
Length = 763
Score = 276 bits (705), Expect = 5e-74
Identities = 157/398 (39%), Positives = 230/398 (57%), Gaps = 11/398 (2%)
Query: 147 LKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLA 206
+K YKH Y + + + + KK V N GYDD + YI +
Sbjct: 101 IKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVY----NDGYDDDNYDYIVKNGEKWM 156
Query: 207 YRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 266
RYE+ +IGKGSFGQV + YD +++VA+K+++N+K F QA E+R+LE + K D
Sbjct: 157 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 216
Query: 267 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD-- 324
++H+ F FRNH+C+ FE+LS +LY+L++ F+G S+ L RKFAQ + +L
Sbjct: 217 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 276
Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGS 384
A + IIHCDLKPENILL + RS+ K++DFGSSC Q++Y YIQSRFYR+PE++LG
Sbjct: 277 ATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGM 336
Query: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN 444
Y ID+WS GCIL E+ TG+PLF G +E DQ+ ++E+LG+PP +L+Q+ +A+ F
Sbjct: 337 PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFE 396
Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSR----RGKKRGPPGSKDWGTALKGCDDYL-FIEFL 499
+ T+ R G + G + G PG + G + DYL F + +
Sbjct: 397 KLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLI 456
Query: 500 KRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVS 537
R L +DP R+ P AL+H + K+ T + VS
Sbjct: 457 LRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVS 494
>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform a [Homo sapiens]
Length = 629
Score = 274 bits (700), Expect = 2e-73
Identities = 150/355 (42%), Positives = 221/355 (62%), Gaps = 11/355 (3%)
Query: 187 NGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF 246
N GYDD + YI + RYE+ +IGKGSFGQV + YDH+ ++ VA+K+++N+K F
Sbjct: 89 NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAF 148
Query: 247 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQG 306
QA E+R+LE + + D ++H+ F FRNH+C+ FELLS +LY+L++ F+G
Sbjct: 149 LNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG 208
Query: 307 FSVQLVRKFAQSILQSLD--ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ 364
S+ L RK AQ + +L A + IIHCDLKPENILL + RS+ K++DFGSSC Q
Sbjct: 209 VSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ 268
Query: 365 KLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424
++Y YIQSRFYR+PE++LG+ Y ID+WS GCIL E+ TG+PLF G +E DQ+ ++E+
Sbjct: 269 RIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEV 328
Query: 425 LGMPPPKLLEQSKRA-KYFINSKGIPRYCSVTTQADGRVVLVGGRSRR-----GKKRGPP 478
LG+PP +L+Q+ +A KYF G ++ + R G +RR G + G P
Sbjct: 329 LGIPPAAMLDQAPKARKYFERLPG--GGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGP 386
Query: 479 GSKDWGTALKGCDDYL-FIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTT 532
G + G DYL F + + R L ++P+AR++P AL+H + ++ T
Sbjct: 387 GGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNT 441
>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform c [Homo sapiens]
Length = 601
Score = 263 bits (671), Expect = 4e-70
Identities = 144/349 (41%), Positives = 211/349 (60%), Gaps = 27/349 (7%)
Query: 187 NGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF 246
N GYDD + YI + RYE+ +IGKGSFGQV + YDH+ ++ VA+K+++N+K F
Sbjct: 89 NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAF 148
Query: 247 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQG 306
QA E+R+LE + + D ++H+ F FRNH+C+ FELLS +LY+L++ F+G
Sbjct: 149 LNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG 208
Query: 307 FSVQLVRKFAQSILQSLD--ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ 364
S+ L RK AQ + +L A + IIHCDLKPENILL + RS+ K++DFGSSC Q
Sbjct: 209 VSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ 268
Query: 365 KLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424
++Y YIQSRFYR+PE++LG+ Y ID+WS GCIL E+ TG+PLF G +E DQ+ ++E+
Sbjct: 269 RIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEV 328
Query: 425 LGMPPPKLLEQSKRA-KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDW 483
LG+PP +L+Q+ +A KYF G GG + R K +
Sbjct: 329 LGIPPAAMLDQAPKARKYFERLPG------------------GGWTLRRTKELRKDYQGP 370
Query: 484 GTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTT 532
GT L + + R L ++P+AR++P AL+H + ++ T
Sbjct: 371 GTR------RLQEDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNT 413
>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform b [Homo sapiens]
Length = 589
Score = 260 bits (665), Expect = 2e-69
Identities = 142/349 (40%), Positives = 208/349 (59%), Gaps = 39/349 (11%)
Query: 187 NGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF 246
N GYDD + YI + RYE+ +IGKGSFGQV + YDH+ ++ VA+K+++N+K F
Sbjct: 89 NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAF 148
Query: 247 HRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQG 306
QA E+R+LE + + D ++H+ F FRNH+C+ FELLS +LY+L++ F+G
Sbjct: 149 LNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG 208
Query: 307 FSVQLVRKFAQSILQSLD--ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQ 364
S+ L RK AQ + +L A + IIHCDLKPENILL + RS+ K++DFGSSC Q
Sbjct: 209 VSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ 268
Query: 365 KLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMEL 424
++Y YIQSRFYR+PE++LG+ Y ID+WS GCIL E+ TG+PLF G +E DQ+ ++E+
Sbjct: 269 RIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEV 328
Query: 425 LGMPPPKLLEQSKRA-KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDW 483
LG+PP +L+Q+ +A KYF G GG + R K
Sbjct: 329 LGIPPAAMLDQAPKARKYFERLPG------------------GGWTLRRTKE-------- 362
Query: 484 GTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTT 532
L + + R L ++P+AR++P AL+H + ++ T
Sbjct: 363 ----------LRKDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNT 401
>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
Length = 526
Score = 207 bits (527), Expect = 2e-53
Identities = 125/349 (35%), Positives = 192/349 (55%), Gaps = 33/349 (9%)
Query: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQ 249
DD +G I D L+ RYE++ +G+G+FG+V DHK ++VA+K+V+N R+
Sbjct: 185 DDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEA 244
Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309
A EI++LEHL D + + MLE F H+C+ FELL + Y+ IK+N F F +
Sbjct: 245 ARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRL 304
Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENIL-------------LKHHGRS----STK 352
+RK A I +S++ LH NK+ H DLKPENIL +K R+ K
Sbjct: 305 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 364
Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412
V+DFGS+ ++ + T + +R YRAPE+IL +S P D+WS GCIL E G +FP
Sbjct: 365 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTH 424
Query: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472
D + LA M +LG P +++++++ KYF + R + GR V SRR
Sbjct: 425 DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHD----RLDWDEHSSAGRYV-----SRRC 475
Query: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPW 521
K K++ + + LF + +++ L +DP+ R+T +AL+HP+
Sbjct: 476 KPL-----KEFMLSQDVEHERLF-DLIQKMLEYDPAKRITLREALKHPF 518
>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
Length = 484
Score = 207 bits (527), Expect = 2e-53
Identities = 125/349 (35%), Positives = 192/349 (55%), Gaps = 33/349 (9%)
Query: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQ 249
DD +G I D L+ RYE++ +G+G+FG+V DHK ++VA+K+V+N R+
Sbjct: 143 DDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEA 202
Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309
A EI++LEHL D + + MLE F H+C+ FELL + Y+ IK+N F F +
Sbjct: 203 ARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRL 262
Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENIL-------------LKHHGRS----STK 352
+RK A I +S++ LH NK+ H DLKPENIL +K R+ K
Sbjct: 263 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 322
Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412
V+DFGS+ ++ + T + +R YRAPE+IL +S P D+WS GCIL E G +FP
Sbjct: 323 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTH 382
Query: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472
D + LA M +LG P +++++++ KYF + R + GR V SRR
Sbjct: 383 DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHD----RLDWDEHSSAGRYV-----SRRC 433
Query: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPW 521
K K++ + + LF + +++ L +DP+ R+T +AL+HP+
Sbjct: 434 KPL-----KEFMLSQDVEHERLF-DLIQKMLEYDPAKRITLREALKHPF 476
>gi|10190706 CDC-like kinase 4 [Homo sapiens]
Length = 481
Score = 204 bits (519), Expect = 2e-52
Identities = 123/349 (35%), Positives = 189/349 (54%), Gaps = 33/349 (9%)
Query: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQ 249
DD +G I D L RYE++ +G+G+FG+V DH + +VA+K+V+N R+
Sbjct: 141 DDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREA 200
Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309
A EI++LEHL D + MLE F HVC+ FELL + Y+ IK+N F F +
Sbjct: 201 ARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQI 260
Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENIL-------LKHHGR----------SSTK 352
+R+ A I QS++ LH NK+ H DLKPENIL +K++ + + K
Sbjct: 261 DHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIK 320
Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412
V+DFGS+ ++ + T + +R YRAPE+IL +S P D+WS GCIL E G +F
Sbjct: 321 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTH 380
Query: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472
D + LA M +LG P +++++++ KYF ++ Q D GR R
Sbjct: 381 DSKEHLAMMERILGPIPQHMIQKTRKRKYFHHN-----------QLDWDEHSSAGRYVR- 428
Query: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPW 521
+R P K++ + LF + ++R L +DP+ R+T +AL+HP+
Sbjct: 429 -RRCKP-LKEFMLCHDEEHEKLF-DLVRRMLEYDPTQRITLDEALQHPF 474
>gi|164420691 homeodomain interacting protein kinase 2 isoform 2
[Homo sapiens]
Length = 1171
Score = 194 bits (494), Expect = 1e-49
Identities = 119/355 (33%), Positives = 182/355 (51%), Gaps = 18/355 (5%)
Query: 186 NNGGYDDADGAYI-HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK 244
N+G + D + H + YEVL+ +G+G+FGQV + + + VA+K+++N
Sbjct: 175 NSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHP 234
Query: 245 RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF 304
+ RQ E+ IL L + N + E F +NH C+ FE+L +LY+ +K+NKF
Sbjct: 235 SYARQGQIEVSILARLSTES-ADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293
Query: 305 QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFE 362
++ +R Q + +L L +IH DLKPENI+L R KVIDFGS+
Sbjct: 294 SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353
Query: 363 YQKLY-TYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 421
+ + TY+QSR+YRAPEIILG + ID+WS GC++AEL G PL+PG E DQ+ +
Sbjct: 354 SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYI 413
Query: 422 MELLGMPPPKLLEQ-SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK-----R 475
+ G+P LL +K ++F P D G +S+ +K
Sbjct: 414 SQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCL 473
Query: 476 GPPGSKDWGTALKGCDDYL-------FIEFLKRCLHWDPSARLTPAQALRHPWIS 523
+ T L+G D + FI+ LK+ L D R+TP + L HP+++
Sbjct: 474 DDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVT 528
>gi|164420685 homeodomain interacting protein kinase 2 isoform 1
[Homo sapiens]
Length = 1198
Score = 194 bits (494), Expect = 1e-49
Identities = 119/355 (33%), Positives = 182/355 (51%), Gaps = 18/355 (5%)
Query: 186 NNGGYDDADGAYI-HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK 244
N+G + D + H + YEVL+ +G+G+FGQV + + + VA+K+++N
Sbjct: 175 NSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHP 234
Query: 245 RFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF 304
+ RQ E+ IL L + N + E F +NH C+ FE+L +LY+ +K+NKF
Sbjct: 235 SYARQGQIEVSILARLSTES-ADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKF 293
Query: 305 QGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFE 362
++ +R Q + +L L +IH DLKPENI+L R KVIDFGS+
Sbjct: 294 SPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHV 353
Query: 363 YQKLY-TYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 421
+ + TY+QSR+YRAPEIILG + ID+WS GC++AEL G PL+PG E DQ+ +
Sbjct: 354 SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYI 413
Query: 422 MELLGMPPPKLLEQ-SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK-----R 475
+ G+P LL +K ++F P D G +S+ +K
Sbjct: 414 SQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCL 473
Query: 476 GPPGSKDWGTALKGCDDYL-------FIEFLKRCLHWDPSARLTPAQALRHPWIS 523
+ T L+G D + FI+ LK+ L D R+TP + L HP+++
Sbjct: 474 DDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVT 528
>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
[Homo sapiens]
Length = 1210
Score = 192 bits (489), Expect = 6e-49
Identities = 115/333 (34%), Positives = 178/333 (53%), Gaps = 21/333 (6%)
Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268
YEVL+ +G+G+FGQVA+ + ++ VA+K+++N + RQ E+ IL L ++
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSEN-ADE 248
Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328
N + E F +NH C+ FE+L +LY+ +K+NKF ++ +R Q + +L L
Sbjct: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308
Query: 329 NKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFEYQKLY-TYIQSRFYRAPEIILGSR 385
+IH DLKPENI+L R KVIDFGS+ + + TY+QSR+YRAPEIILG
Sbjct: 309 LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP 368
Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN- 444
+ ID+WS GC++AEL G PL+PG E DQ+ + + G+P LL + F N
Sbjct: 369 FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNR 428
Query: 445 --SKGIPRYCSVTTQADGRVVLVGGRSRRGKK-----RGPPGSKDWGTALKGCDDYL--- 494
+ G P + T + + G +S+ +K + T L+G D
Sbjct: 429 DPNLGYPLWRLKTPEE--HELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKA 486
Query: 495 ----FIEFLKRCLHWDPSARLTPAQALRHPWIS 523
+I+ LK+ L D R+TP + L H +++
Sbjct: 487 DRREYIDLLKKMLTIDADKRITPLKTLNHQFVT 519
>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
[Homo sapiens]
Length = 1075
Score = 192 bits (489), Expect = 6e-49
Identities = 115/333 (34%), Positives = 178/333 (53%), Gaps = 21/333 (6%)
Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268
YEVL+ +G+G+FGQVA+ + ++ VA+K+++N + RQ E+ IL L ++
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSEN-ADE 248
Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328
N + E F +NH C+ FE+L +LY+ +K+NKF ++ +R Q + +L L
Sbjct: 249 YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS 308
Query: 329 NKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFEYQKLY-TYIQSRFYRAPEIILGSR 385
+IH DLKPENI+L R KVIDFGS+ + + TY+QSR+YRAPEIILG
Sbjct: 309 LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP 368
Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFIN- 444
+ ID+WS GC++AEL G PL+PG E DQ+ + + G+P LL + F N
Sbjct: 369 FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNR 428
Query: 445 --SKGIPRYCSVTTQADGRVVLVGGRSRRGKK-----RGPPGSKDWGTALKGCDDYL--- 494
+ G P + T + + G +S+ +K + T L+G D
Sbjct: 429 DPNLGYPLWRLKTPEE--HELETGIKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKA 486
Query: 495 ----FIEFLKRCLHWDPSARLTPAQALRHPWIS 523
+I+ LK+ L D R+TP + L H +++
Sbjct: 487 DRREYIDLLKKMLTIDADKRITPLKTLNHQFVT 519
>gi|47717134 CDC-like kinase 2 [Homo sapiens]
Length = 498
Score = 189 bits (481), Expect = 5e-48
Identities = 110/357 (30%), Positives = 185/357 (51%), Gaps = 33/357 (9%)
Query: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQ 249
DDA+G I+ D L RYE++ +G+G+FG+V + DH+ VALK+++N +++
Sbjct: 144 DDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEA 203
Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309
A EI +LE + ++D + M + F + H+C++FELL + ++ +K N + + +
Sbjct: 204 ARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPI 263
Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILL-------------KHHGRS----STK 352
VR A + Q++ LH NK+ H DLKPENIL K RS + +
Sbjct: 264 HQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVR 323
Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412
V+DFGS+ F+++ T + +R YRAPE+IL +S P D+WS GCI+ E G LF
Sbjct: 324 VVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTH 383
Query: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472
D + LA M +LG P +++ ++++ KYF R + GR V + R
Sbjct: 384 DNREHLAMMERILGPIPSRMIRKTRKQKYFYRG----RLDWDENTSAGRYVRENCKPLRR 439
Query: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRP 529
+ + + + ++ L ++P+ RLT +AL+HP+ ++ P
Sbjct: 440 Y-----------LTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEP 485
>gi|114796630 homeodomain interacting protein kinase 3 isoform 2
[Homo sapiens]
Length = 1194
Score = 188 bits (478), Expect = 1e-47
Identities = 114/331 (34%), Positives = 174/331 (52%), Gaps = 17/331 (5%)
Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268
YEVL +G+G+FGQV + + + VA+K+++N + RQ E+ IL L ++
Sbjct: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTEN-ADE 255
Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328
N + E F RNH C+ FE+L +LY+ +K+NKF ++++R Q + +L L
Sbjct: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
Query: 329 NKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFEYQKLY-TYIQSRFYRAPEIILGSR 385
+IH DLKPENI+L R KVIDFGS+ + + TY+QSR+YRAPEIILG
Sbjct: 316 LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLP 375
Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE-QSKRAKYFIN 444
+ ID+WS GC++AEL G PL+PG E DQ+ + + G+P +LL +K ++F
Sbjct: 376 FCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCK 435
Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA-----LKG-------CDD 492
+ + G +S+ +K D L+G D
Sbjct: 436 ETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADR 495
Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523
F+ LK+ L D R+TPA+ L HP+++
Sbjct: 496 REFVSLLKKMLLIDADLRITPAETLNHPFVN 526
>gi|114796624 homeodomain interacting protein kinase 3 isoform 1
[Homo sapiens]
Length = 1215
Score = 188 bits (478), Expect = 1e-47
Identities = 114/331 (34%), Positives = 174/331 (52%), Gaps = 17/331 (5%)
Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268
YEVL +G+G+FGQV + + + VA+K+++N + RQ E+ IL L ++
Sbjct: 197 YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTEN-ADE 255
Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328
N + E F RNH C+ FE+L +LY+ +K+NKF ++++R Q + +L L
Sbjct: 256 YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS 315
Query: 329 NKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFEYQKLY-TYIQSRFYRAPEIILGSR 385
+IH DLKPENI+L R KVIDFGS+ + + TY+QSR+YRAPEIILG
Sbjct: 316 LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLP 375
Query: 386 YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE-QSKRAKYFIN 444
+ ID+WS GC++AEL G PL+PG E DQ+ + + G+P +LL +K ++F
Sbjct: 376 FCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCK 435
Query: 445 SKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA-----LKG-------CDD 492
+ + G +S+ +K D L+G D
Sbjct: 436 ETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADR 495
Query: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523
F+ LK+ L D R+TPA+ L HP+++
Sbjct: 496 REFVSLLKKMLLIDADLRITPAETLNHPFVN 526
>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
Length = 638
Score = 187 bits (475), Expect = 2e-47
Identities = 114/355 (32%), Positives = 183/355 (51%), Gaps = 33/355 (9%)
Query: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDH-KLRQYVALKMVRNEKRFHRQ 249
DD +G + D L RYE++ +G+G+FG+V DH + + VALK++RN ++
Sbjct: 286 DDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREA 345
Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309
A EI +L+ +K++DK + M + F F H+C+AFELL + +E +K+N FQ + +
Sbjct: 346 ARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPL 405
Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILL-----------------KHHGRSSTK 352
VR A + +L LH+N++ H DLKPENIL K +S +
Sbjct: 406 PHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIR 465
Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412
V DFGS+ F+++ T + +R YR PE+IL ++ P D+WS GCIL E G LF
Sbjct: 466 VADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTH 525
Query: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472
+ + L M ++LG P ++ ++++ KYF + S +DGR V
Sbjct: 526 ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENS----SDGRYV--------- 572
Query: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVP 527
K K + + + ++R L +DP+ R+T A+AL HP+ + P
Sbjct: 573 -KENCKPLKSY-MLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTP 625
>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
Length = 490
Score = 187 bits (475), Expect = 2e-47
Identities = 114/355 (32%), Positives = 183/355 (51%), Gaps = 33/355 (9%)
Query: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDH-KLRQYVALKMVRNEKRFHRQ 249
DD +G + D L RYE++ +G+G+FG+V DH + + VALK++RN ++
Sbjct: 138 DDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREA 197
Query: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309
A EI +L+ +K++DK + M + F F H+C+AFELL + +E +K+N FQ + +
Sbjct: 198 ARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPL 257
Query: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILL-----------------KHHGRSSTK 352
VR A + +L LH+N++ H DLKPENIL K +S +
Sbjct: 258 PHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIR 317
Query: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412
V DFGS+ F+++ T + +R YR PE+IL ++ P D+WS GCIL E G LF
Sbjct: 318 VADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTH 377
Query: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472
+ + L M ++LG P ++ ++++ KYF + S +DGR V
Sbjct: 378 ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENS----SDGRYV--------- 424
Query: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVP 527
K K + + + ++R L +DP+ R+T A+AL HP+ + P
Sbjct: 425 -KENCKPLKSY-MLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTP 477
>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
Length = 616
Score = 180 bits (456), Expect = 4e-45
Identities = 114/343 (33%), Positives = 179/343 (52%), Gaps = 33/343 (9%)
Query: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268
Y++++++GKG+FG+VA+ + + VA+K+++N+ +R E+++L ++ D +
Sbjct: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEA 70
Query: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328
+VI LE F + FELL +L+E K+N F + +R +L +L L +
Sbjct: 71 -HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKE 129
Query: 329 NKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFEYQKLYT---YIQSRFYRAPEIILG 383
IIH DLKPENI+L R KVIDFGS+ + Y YIQSRFYRAPEI+LG
Sbjct: 130 LAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLG 189
Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443
+ +D+WS GC++AEL G PL+PG +E DQ+ + E G+P P LL + +A +F
Sbjct: 190 LPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFF 249
Query: 444 NSKGIPRYCS---VTTQAD--------------------GRVVLVGGRSRRGKKRGPPGS 480
P + + + AD ++ V G S + P
Sbjct: 250 KRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFP--- 306
Query: 481 KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523
D + D +E +KR L W+ R++P+ ALRHP++S
Sbjct: 307 -DREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVS 348
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 162 bits (409), Expect = 1e-39
Identities = 109/349 (31%), Positives = 171/349 (48%), Gaps = 21/349 (6%)
Query: 190 YDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDH-KLRQYVALKMVRNEKRFHR 248
+ DA+G Y + L RY V G+G F V R D+ + Q VA+K++RN + +
Sbjct: 668 WTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQK 727
Query: 249 QAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK-NKFQGF 307
+E+ L+ L D + + + F + H+C+ FE LS++L E++KK K G
Sbjct: 728 TGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGL 787
Query: 308 SVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLY 367
++ VR ++Q + +L L + I+H D+KP+NIL+ + ++ K+ DFGS+
Sbjct: 788 HIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILV-NESKTILKLCDFGSASHVADNDI 846
Query: 368 T-YIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLG 426
T Y+ SRFYRAPEII+G Y ID+WS GC L EL TG+ LFPG+ L M+L G
Sbjct: 847 TPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKG 906
Query: 427 MPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA 486
P K++ + + Y V + V V +KD
Sbjct: 907 KMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTIN--------PTKDLLAD 958
Query: 487 LKGCDD---------YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSV 526
L GC + + L + L DP+ R++ QAL+H +I + +
Sbjct: 959 LIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 1007
>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
Length = 364
Score = 150 bits (380), Expect = 2e-36
Identities = 110/350 (31%), Positives = 177/350 (50%), Gaps = 47/350 (13%)
Query: 182 IGGPNNGGY-DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV 240
+ GP G Y + + VP+ R + L+ +G G++G V YD +LRQ VA+K +
Sbjct: 1 MSGPRAGFYRQELNKTVWEVPQ-----RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKL 55
Query: 241 RN--EKRFH-RQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYE 297
+ H R+ E+R+L+HLK ++ G ++V S + V + L+ DL
Sbjct: 56 SRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNN 115
Query: 298 LIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG 357
++K Q S + V+ +L+ L +H IIH DLKP N+ + +++DFG
Sbjct: 116 IVK---CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNED--CELRILDFG 170
Query: 358 SSCFEYQKLYTYIQSRFYRAPEIILG-SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD 416
+ +++ Y+ +R+YRAPEI+L Y+ +DIWS GCI+AELL G+ LFPG D D
Sbjct: 171 LARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID 230
Query: 417 QLACMMELLGMPPPKLLEQ--SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK 474
QL +ME++G P P++L + S+ A+ +I S +P
Sbjct: 231 QLKRIMEVVGTPSPEVLAKISSEHARTYIQS--LP------------------------- 263
Query: 475 RGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISK 524
P KD + +G + L I+ L R L D R++ A+AL H + S+
Sbjct: 264 --PMPQKDLSSIFRGANP-LAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 310
>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
sapiens]
Length = 360
Score = 143 bits (361), Expect = 4e-34
Identities = 99/321 (30%), Positives = 158/321 (49%), Gaps = 37/321 (11%)
Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN--EKRFH-RQAAEEIRILEHLKKQD 264
RY+ L +G G++G V +D K VA+K + + H ++ E+R+L+H+K ++
Sbjct: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82
Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324
G ++V S N V + L+ DL ++K K VQ + IL+ L
Sbjct: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL---IYQILRGLK 139
Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG- 383
+H IIH DLKP N+ + K++DFG + ++ Y+ +R+YRAPEI+L
Sbjct: 140 YIHSADIIHRDLKPSNLAVNED--CELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNW 197
Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443
Y+ +DIWS GCI+AELLTG+ LFPG D DQL ++ L+G P +LL++ I
Sbjct: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK-------I 250
Query: 444 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL 503
+S+ Y TQ ++ G + L ++ L++ L
Sbjct: 251 SSESARNYIQSLTQMP--------------------KMNFANVFIGANP-LAVDLLEKML 289
Query: 504 HWDPSARLTPAQALRHPWISK 524
D R+T AQAL H + ++
Sbjct: 290 VLDSDKRITAAQALAHAYFAQ 310
>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
sapiens]
Length = 297
Score = 140 bits (352), Expect = 4e-33
Identities = 86/244 (35%), Positives = 135/244 (55%), Gaps = 11/244 (4%)
Query: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRN--EKRFH-RQAAEEIRILEHLKKQD 264
RY+ L +G G++G V +D K VA+K + + H ++ E+R+L+H+K ++
Sbjct: 23 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 82
Query: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324
G ++V S N V + L+ DL ++K K VQ + IL+ L
Sbjct: 83 VIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFL---IYQILRGLK 139
Query: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG- 383
+H IIH DLKP N+ + K++DFG + ++ Y+ +R+YRAPEI+L
Sbjct: 140 YIHSADIIHRDLKPSNLAVNED--CELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNW 197
Query: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ--SKRAKY 441
Y+ +DIWS GCI+AELLTG+ LFPG D DQL ++ L+G P +LL++ S+ A+
Sbjct: 198 MHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARN 257
Query: 442 FINS 445
+I S
Sbjct: 258 YIQS 261
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,295,670
Number of Sequences: 37866
Number of extensions: 1353525
Number of successful extensions: 6271
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 593
Number of HSP's successfully gapped in prelim test: 198
Number of HSP's that attempted gapping in prelim test: 4097
Number of HSP's gapped (non-prelim): 1254
length of query: 588
length of database: 18,247,518
effective HSP length: 108
effective length of query: 480
effective length of database: 14,157,990
effective search space: 6795835200
effective search space used: 6795835200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.