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Search of human proteins with 51479184
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|51479184 kelch repeat and BTB (POZ) domain containing 1
[Homo sapiens]
(634 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 1282 0.0
gi|24308181 kelch-like 9 [Homo sapiens] 383 e-106
gi|45643138 kelch-like 13 [Homo sapiens] 379 e-105
gi|8922854 kelch-like 26 [Homo sapiens] 369 e-102
gi|55741643 kelch-like 14 [Homo sapiens] 328 1e-89
gi|31542246 kelch-like 36 [Homo sapiens] 310 2e-84
gi|156616301 kelch-like 32 [Homo sapiens] 274 2e-73
gi|24432026 kelch-like [Homo sapiens] 269 7e-72
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 266 6e-71
gi|38194229 kelch-like 17 [Homo sapiens] 247 2e-65
gi|40807500 kelch-like 20 [Homo sapiens] 241 2e-63
gi|226442729 kelch-like 15 [Homo sapiens] 234 1e-61
gi|55925604 kelch-like 18 [Homo sapiens] 233 3e-61
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 232 7e-61
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 232 7e-61
gi|166235129 kelch-like 3 [Homo sapiens] 229 8e-60
gi|14780904 kelch-like 1 protein [Homo sapiens] 227 3e-59
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 224 2e-58
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 224 2e-58
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 220 3e-57
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 214 3e-55
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 208 1e-53
gi|40018614 DRE1 protein [Homo sapiens] 205 9e-53
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 204 2e-52
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 204 2e-52
gi|11056006 kelch-like 12 [Homo sapiens] 203 4e-52
gi|23397572 kelch-like 34 [Homo sapiens] 203 4e-52
gi|148664209 kelch-like 10 [Homo sapiens] 201 2e-51
gi|34101268 kelch-like 8 [Homo sapiens] 199 5e-51
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 198 1e-50
>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
sapiens]
Length = 634
Score = 1282 bits (3317), Expect = 0.0
Identities = 634/634 (100%), Positives = 634/634 (100%)
Query: 1 MAPKKKIVKKNKGDINEMTIIVEDSPLNKLNALNGLLEGGNGLSCISSELTDASYGPNLL 60
MAPKKKIVKKNKGDINEMTIIVEDSPLNKLNALNGLLEGGNGLSCISSELTDASYGPNLL
Sbjct: 1 MAPKKKIVKKNKGDINEMTIIVEDSPLNKLNALNGLLEGGNGLSCISSELTDASYGPNLL 60
Query: 61 EGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSIQRVDLNDISPLG 120
EGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSIQRVDLNDISPLG
Sbjct: 61 EGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSIQRVDLNDISPLG 120
Query: 121 LATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIAE 180
LATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIAE
Sbjct: 121 LATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIAE 180
Query: 181 TYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMKW 240
TYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMKW
Sbjct: 181 TYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMKW 240
Query: 241 LEFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYHLLPYH 300
LEFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYHLLPYH
Sbjct: 241 LEFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYHLLPYH 300
Query: 301 QNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCV 360
QNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCV
Sbjct: 301 QNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCV 360
Query: 361 AVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGL 420
AVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGL
Sbjct: 361 AVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGL 420
Query: 421 VYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAYS 480
VYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAYS
Sbjct: 421 VYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAYS 480
Query: 481 RSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSP 540
RSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSP
Sbjct: 481 RSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSP 540
Query: 541 ATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWTEDDEL 600
ATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWTEDDEL
Sbjct: 541 ATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWTEDDEL 600
Query: 601 PEATVGVSCCTLSMPNNVTRESRASSVSSVPVSI 634
PEATVGVSCCTLSMPNNVTRESRASSVSSVPVSI
Sbjct: 601 PEATVGVSCCTLSMPNNVTRESRASSVSSVPVSI 634
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 383 bits (983), Expect = e-106
Identities = 216/613 (35%), Positives = 335/613 (54%), Gaps = 28/613 (4%)
Query: 40 GNGLSCISSEL-----------TDASYGPNLLEGLSKMRQENFLCD--LVIGTKTKSFDV 86
GNG +S+ L T ++ +L+G ++R E LCD LV G + F V
Sbjct: 6 GNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPV 65
Query: 87 HKSVMASCSEYFYNILK---KDPSIQRVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSI 143
H+++MAS S+YF + K+ + + L+ ++ +GL +I + YT KL+L++ +
Sbjct: 66 HRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDT 125
Query: 144 ISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFA 203
+ AA +LQI ++ C FLI +S++NC+ V IA TY+L FI NF
Sbjct: 126 LEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALL 185
Query: 204 ESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMKWLEFDQKRVKYAADLLSNIRFGTI 263
+ +F+KL FE++ +L + L+ +E+ F+ A +WL + R+ YAA L+ NIRF +
Sbjct: 186 STGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLM 245
Query: 264 SAQDLVNYVQSVPRMMQDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGG 323
+ QDL+NYVQ+V M D C LL++A NY ++PY Q +QS RT IR LVT+GG
Sbjct: 246 TPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGG 305
Query: 324 --RPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQ 381
R L R +Y + W L M A + +AV+ FLYV GG+ D +
Sbjct: 306 VLRQQLVVSKELR--MYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKG- 362
Query: 382 AKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVP 441
K AV R+DPR+N W+ +AS+N+KRT F LS G +YA GGR+A G LA++ECY P
Sbjct: 363 -KTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNP 421
Query: 442 STNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLST 501
N+W + HA V G + ++GG + + + +DP +D W + ++T
Sbjct: 422 RMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTT 481
Query: 502 PRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVS 561
RG HC T+ D++YV+GG+ + DVL+ E YSP QW+ A + G S GV+
Sbjct: 482 VRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVA 541
Query: 562 ALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWTEDDELPEATVGVSCCTLSM------P 615
+ Y+VGG++ + + +Q + PE +EW + +LPE+ G+ CTL++ P
Sbjct: 542 VFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEENP 601
Query: 616 NNVTRESRASSVS 628
+ +RES S+ S
Sbjct: 602 GSPSRESPLSAPS 614
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 379 bits (973), Expect = e-105
Identities = 210/613 (34%), Positives = 333/613 (54%), Gaps = 25/613 (4%)
Query: 39 GGNGLSCISSELTDASYGPN-----------LLEGLSKMRQENFLCDLVI--GTKTKSFD 85
GG+ + +SS L + GP +L+G ++R E LCD+ + G +F
Sbjct: 48 GGSEMG-LSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFP 106
Query: 86 VHKSVMASCSEYFYNILK---KDPSIQRVDLNDISPLGLATVIAYAYTGKLTLSLYTIGS 142
VH+ +MAS S+YF + K+ + + L+ +S +GL +I + YT KL+L++ +
Sbjct: 107 VHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQD 166
Query: 143 IISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEF 202
+ AA +LQI ++ C FLI ++++NC+ V IA TY+L F+ NF
Sbjct: 167 TLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPAL 226
Query: 203 AESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMKWLEFDQKRVKYAADLLSNIRFGT 262
+ +F+KL FE++ +L + L+ +E+ F+ +WL ++ R+ +AA L+ NIRF
Sbjct: 227 LSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPL 286
Query: 263 ISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVG 322
++ Q+L+NYVQ+V M D C LL++A NY ++PY Q +QS RT IR LVT+G
Sbjct: 287 MTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLG 346
Query: 323 G--RPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARN 380
G R L R +Y + + W L M A + +AV+ FLYV GG+ D +
Sbjct: 347 GVLRQQLVVSKELR--MYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKG 404
Query: 381 QAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYV 440
K AV R+DPR+N W+ +AS+N+KRT F LS G +YA GGRNA G L ++ECY
Sbjct: 405 --KTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYN 462
Query: 441 PSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLS 500
P TN+W + HA V G + ++GG + + + + +DP +D W + ++
Sbjct: 463 PRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMT 522
Query: 501 TPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGV 560
T RG HC T+ +R+YV+GG+ + DVL+ E YSP QW+ A + G S GV
Sbjct: 523 TVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGV 582
Query: 561 SALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWTEDDELPEATVGVSCCTLSM--PNNV 618
+ + Y+VGG++ + + +Q + P+ +EW + +LPE+ G+ CTL++ P
Sbjct: 583 AVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEET 642
Query: 619 TRESRASSVSSVP 631
T S S P
Sbjct: 643 TPSPSRESPLSAP 655
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 369 bits (946), Expect = e-102
Identities = 210/595 (35%), Positives = 336/595 (56%), Gaps = 15/595 (2%)
Query: 34 NGLLEGGNGLSCISSELTDASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMAS 93
N + L C S S+ +LL+GL+ +R + L D+V+ ++F HK V+A+
Sbjct: 27 NSTADKNGALKCTFSA---PSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAA 83
Query: 94 CSEYFYNILK---KDPSIQRVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYL 150
CS+YF + ++ S ++L +S GL +I +AY+ ++TL L + ++ AAV+L
Sbjct: 84 CSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFL 143
Query: 151 QIHTLVKMCSDFLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMK 210
Q+ +V++C +FL MSVE C+ + +A T+SL + + + F +FL+ AE + F++
Sbjct: 144 QMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLR 203
Query: 211 LTFEQINELLIDDDLQLPSEIVAFQIAMKWLEFDQKRVKYAADLLSNIRFGTISAQDLVN 270
L E++ L + LQ +EI F+ A++WL+ D R A+ +L +IRF + + +LV+
Sbjct: 204 LPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVD 263
Query: 271 YVQSVPRMMQDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGL-TE 329
VQ++ M++D C + L++A NY +LP+ Q+ +QS RT +R LVT GG P ++
Sbjct: 264 SVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSD 323
Query: 330 KSLSRDILYRDPENG---WSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAV 386
+S+S + Y+ PE G + +LTEM + CVAV+D F+YVAGG Q+ + AV
Sbjct: 324 RSVSSKV-YQLPEPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGG--QHLQYRSGEGAV 380
Query: 387 SNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQW 446
RYDP N W+ L +M + R F L+V G+VYA GGRN GSLAS+E Y P N+W
Sbjct: 381 DACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEW 440
Query: 447 QPKTPLEVARCCHASAVADGRVLVTGGY-IANAYSRSVCAYDPASDSWQELPNLSTPRGW 505
L+ HA A + GR+ ++GGY I+ +++ YDP +D W+ +S PR
Sbjct: 441 GYACSLKRRTWGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVL 500
Query: 506 HCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHG 565
H V R+Y +GG ++ DVL VE Y P T QW+ +P++ G S AG L
Sbjct: 501 HAMVGAGGRIYALGG-RMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLER 559
Query: 566 RAYLVGGWNEGEKKYKKCIQCFSPELNEWTEDDELPEATVGVSCCTLSMPNNVTR 620
+ Y+VGG+N +Q ++ + +EW D PE+ G++C + +P TR
Sbjct: 560 KIYIVGGYNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAGIACAPVLLPRAGTR 614
>gi|55741643 kelch-like 14 [Homo sapiens]
Length = 628
Score = 328 bits (840), Expect = 1e-89
Identities = 191/523 (36%), Positives = 285/523 (54%), Gaps = 18/523 (3%)
Query: 101 ILKKDPSIQRVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCS 160
+L +I + L S +GL V+ Y YT +TLSL T+ ++S + L I + K+C
Sbjct: 115 LLTSPRAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCV 174
Query: 161 DFLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELL 220
FL ++SV+N V IA + L+ K A K++ ++ L L FE++ LL
Sbjct: 175 QFLNDQISVQNYKQVCKIAALHGLEETKKLANKYLVEDVL---------LLNFEEMRALL 225
Query: 221 IDDDLQLPSEIVAFQIAMKWLEFDQK-RVKYAADLLSNIRFGTISAQDLVNYVQSVPRMM 279
+ SE+ FQ+++ WLE D++ R++YA DL+ +RF I A +LV VQSV M
Sbjct: 226 DSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMR 285
Query: 280 QDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYR 339
D C +LL+DAMNYHL+P+ Q+ QS +RIR ++L+ VGG P ++ S + Y
Sbjct: 286 TDPVCQKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYY 345
Query: 340 DPENG-WSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNT 398
D E W LT MP S + CV ++ FL+V GGEDQ + KH+ + RYDPRFN+
Sbjct: 346 DDEKKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNG--KHSTNFVSRYDPRFNS 403
Query: 399 WIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCC 458
WI L M ++R F + +Y GGRN G L+S+ECY TN+W+ + L
Sbjct: 404 WIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAA 463
Query: 459 HASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVM 518
HA AV +G++ ++GG Y + YDP D W +++T R H ++DR+Y +
Sbjct: 464 HAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAI 523
Query: 519 GGSQLGPRG-ERVDVLTVECYSPATGQWS-YAAPLQVGVSTAGVSALHGRAYLVGGWNEG 576
GG+ L +G +DV+ VECY P QW+ P+ G S G + L YLVGG++
Sbjct: 524 GGNHL--KGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWS 581
Query: 577 EKKYKKCIQCFSPELNEWTE-DDELPEATVGVSCCTLSMPNNV 618
YK C+ PE WTE + ++ E G +C T+ +P+ V
Sbjct: 582 MGAYKSSTICYCPEKGTWTELEGDVAEPLAGPACVTVILPSCV 624
Score = 50.1 bits (118), Expect = 6e-06
Identities = 20/57 (35%), Positives = 35/57 (61%)
Query: 52 DASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSI 108
D S+ NLL GL+ + ++ CD+ + + + F HK+V+ASCS+YF ++ P +
Sbjct: 12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPL 68
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 310 bits (795), Expect = 2e-84
Identities = 185/572 (32%), Positives = 300/572 (52%), Gaps = 12/572 (2%)
Query: 53 ASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYF---YNILKKDPSIQ 109
A + +L+ L++ R CD+V+ + H++++A CS+YF + I ++ +
Sbjct: 26 ADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQK 85
Query: 110 RVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSV 169
V+L S +GL V+ + Y G+L L I ++ A LQI T+V C ++L +E+S
Sbjct: 86 EVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSE 145
Query: 170 ENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMK-LTFEQINELLIDDDLQLP 228
+N +Y+ +A YSLK A FI ++F + + F++ ++ +++ L ++Q
Sbjct: 146 DNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRE 205
Query: 229 SEIVAFQIAMKWLEFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSV--PRMMQDADCHR 286
E Q A++WL +R +A +L NI F I DL++ V+ + ++A+C
Sbjct: 206 CEHDLLQAALQWLTQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEG 265
Query: 287 LLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPENG-W 345
+ +A+ YH Q +Q++RT +R L+ VGG LS D Y D ++ W
Sbjct: 266 FIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCYLDAKSEQW 325
Query: 346 SKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASM 405
K T +PA+ + CVAV+ GF+++AGG D N A + RYDPR WI +ASM
Sbjct: 326 VKETPLPARRSHHCVAVLGGFIFIAGGSFSRD--NGGDAASNLLYRYDPRCKQWIKVASM 383
Query: 406 NQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVAD 465
NQ+R F L+ ++ A GGRN G+L+S+E Y P T+ W L HA +
Sbjct: 384 NQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYK 443
Query: 466 GRVLVTGG--YIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQL 523
V ++GG Y Y +++ YD +D W+E ++T RGWH +L D +Y +GGS
Sbjct: 444 DFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDD 503
Query: 524 GPRG-ERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKK 582
ER DVL VE YSP QW+ APL S +GV+ GR Y++GG++ + K
Sbjct: 504 NIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSK 563
Query: 583 CIQCFSPELNEWTEDDELPEATVGVSCCTLSM 614
+Q + E ++W+ +LP+A G S C ++
Sbjct: 564 TVQVYDREADKWSRGVDLPKAIAGGSACVCAL 595
>gi|156616301 kelch-like 32 [Homo sapiens]
Length = 620
Score = 274 bits (700), Expect = 2e-73
Identities = 178/583 (30%), Positives = 294/583 (50%), Gaps = 26/583 (4%)
Query: 54 SYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYF---YNILKKDPSIQR 110
S+ ++L L++ R + LCD+ + + + F HK+V+A+CS+YF +++ +
Sbjct: 23 SHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADE 82
Query: 111 VDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVE 170
V+L+ ++ LGL + +AYTG++ L I +++A +LQ+ L+ +CS +LI+E++
Sbjct: 83 VNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSF 142
Query: 171 NCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAES--DQFMKLTFEQINELLIDDDLQLP 228
N + + +A+ ++L + A F+ + E +S ++ + L + + E+L D L
Sbjct: 143 NYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSL 202
Query: 229 SEIVAFQIAMKWLEFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLL 288
SE +Q+A++WLE + +Y +LL IRFG + L S P + L+
Sbjct: 203 SEEQIWQLAVRWLEHN-CHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALV 261
Query: 289 VDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDP---EN-- 343
+A+ YH Y Q Q+RRT+ R L +GG+ E +++ Y +P EN
Sbjct: 262 NEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKK--REVCKVKELRYFNPVDQENAL 319
Query: 344 -----GWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNT 398
WS+L MP + CVAVM FL+VAGGE ++ + AV CRYDPR N+
Sbjct: 320 IAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTC--AVRTACRYDPRSNS 377
Query: 399 WIHLASMNQKRTHFSLSVFNGLVYAAGGRN-AEGSLASLECYVPSTNQWQPKTPLEVARC 457
W +A M R HF L +YA GGRN L ++E Y P N+W + +
Sbjct: 378 WAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLS 437
Query: 458 CHASAVADGRVLVTGGYIANA-YSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVY 516
CHA VADG + ++GG A Y + Y+P + W + R +H + ++Y
Sbjct: 438 CHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLY 497
Query: 517 VMGGSQLGPRGERVDVLTVECYSPATGQWSYA-APLQVGVSTAGVSALHGRAYLVGGWNE 575
V+GG+ L +R+ V ++ Y+ T QW+ L G + +GV+ +GR YLVGG++
Sbjct: 498 VLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYSI 557
Query: 576 GEKKYKKCIQCFSPELNEWTE---DDELPEATVGVSCCTLSMP 615
+ CIQ E LP A+ G++ C L P
Sbjct: 558 WTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAP 600
>gi|24432026 kelch-like [Homo sapiens]
Length = 634
Score = 269 bits (687), Expect = 7e-72
Identities = 167/588 (28%), Positives = 281/588 (47%), Gaps = 20/588 (3%)
Query: 45 CISSELTDASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILK- 103
C+++ A + LL GL +R L D+V+ + + + H+ ++A+ +YF +
Sbjct: 22 CVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAG 81
Query: 104 --KDPSIQRVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSD 161
K+ + V ++ +S + ++ + YT +L LSL + + AA LQI ++ C D
Sbjct: 82 GLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCD 141
Query: 162 FLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLI 221
FL+ + EN + V +AE + L +I NF+ F+ +D++ +L E++ LL
Sbjct: 142 FLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLS 201
Query: 222 DDDLQLPSEIVAFQIAMKW------LEFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSV 275
+ L++ E ++ A+ + ++ DQ + LL +RF + A+ L Q +
Sbjct: 202 SNRLEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVL----QRL 257
Query: 276 PRMMQDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRD 335
+ + + A+ YH Q +LQS +T +R + +V GG LS
Sbjct: 258 HDKLDPSPLRDTVASALMYHRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQ 317
Query: 336 ILYRDPENG-WSKLT-EMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYD 393
Y +P G W T + + NQ +AV++ F+Y+ GG D Q A S RYD
Sbjct: 318 AKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGG----DNNVQGFRAESRCWRYD 373
Query: 394 PRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLE 453
PR N W + S+ Q+ S+ V +YA GR+ L ++E Y P+TN W PL+
Sbjct: 374 PRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLK 433
Query: 454 VARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSD 513
HA A +G++ +T G Y + YDP S++W L + R WH TL +
Sbjct: 434 REVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLN 493
Query: 514 RVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGW 573
++YV+GGS G R DV V CYS +GQWS PL G G++ L R Y++GG
Sbjct: 494 KLYVIGGSN-NDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGR 552
Query: 574 NEGEKKYKKCIQCFSPELNEWTEDDELPEATVGVSCCTLSMPNNVTRE 621
+ + + E + W E +L + G++ C L++P ++ E
Sbjct: 553 SHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLPRSLLLE 600
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 266 bits (679), Expect = 6e-71
Identities = 168/551 (30%), Positives = 275/551 (49%), Gaps = 21/551 (3%)
Query: 55 YGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFY-----NILKKDPSIQ 109
+ LL+GL+ +RQ + LCD+++ HK V+AS S YF N+ +K+ S
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENS-- 74
Query: 110 RVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSV 169
V+ I L ++ YAYTG + +S T+ S++ AA LQI ++K C FL ++
Sbjct: 75 EVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDP 134
Query: 170 ENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPS 229
NC+ + AETY ++ AA K+I NF ++++F +LT ++E++ +D L + +
Sbjct: 135 GNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVAT 194
Query: 230 EIVAFQIAMKWLEFD-QKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLL 288
E F W+++D Q+R KY A LL+++R +S + L ++ + D C LL
Sbjct: 195 EETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLL 254
Query: 289 VDAMNYHLLPYHQNTLQS-RRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPENGWSK 347
+A+ YH +P H+ + Q+ TR R +VL VGG+ GL L +Y + W
Sbjct: 255 NEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLF-ACLDSVEMYFPQNDSWIG 313
Query: 348 LTEMPAKSFNQCVAVMDGFLYVAGGEDQN--DARNQAKHAVSNFCRYDPRFNTWIHLASM 405
L + + + V+D +YV GG N KH S C ++P NTW L M
Sbjct: 314 LAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVEC-WNPDTNTWTSLERM 372
Query: 406 NQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVAD 465
N+ R+ + V G +YA GG + + L S+E Y+P +WQP P+ R C A+AV D
Sbjct: 373 NESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLD 432
Query: 466 GRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGP 525
G + GGY A+ SV YDP+ DSW+ + +++ R + ++V+GG
Sbjct: 433 GMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGG----- 486
Query: 526 RGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQ 585
+ ++E Y P QW+ P++ + G + + Y+VGG Y +Q
Sbjct: 487 HNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGG--HSGSSYLNTVQ 544
Query: 586 CFSPELNEWTE 596
+ P + W +
Sbjct: 545 KYDPISDTWLD 555
Score = 60.1 bits (144), Expect = 6e-09
Identities = 38/141 (26%), Positives = 61/141 (43%), Gaps = 10/141 (7%)
Query: 317 VLVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQN 376
++ +GG S+ R Y ++ W + M K + V VM GF++V GG
Sbjct: 434 MIYAIGGYGPAHMNSVER---YDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGH--- 487
Query: 377 DARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASL 436
N H +S+ RYDP N W M + RT +V + +Y GG + L ++
Sbjct: 488 ---NGVSH-LSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTV 543
Query: 437 ECYVPSTNQWQPKTPLEVARC 457
+ Y P ++ W + RC
Sbjct: 544 QKYDPISDTWLDSAGMIYCRC 564
Score = 43.9 bits (102), Expect = 5e-04
Identities = 23/82 (28%), Positives = 41/82 (50%), Gaps = 8/82 (9%)
Query: 534 TVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEK------KYKKCIQCF 587
+VE Y P W APL + G+ L + Y++GG + K++ ++C+
Sbjct: 300 SVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECW 359
Query: 588 SPELNEWTEDDELPE--ATVGV 607
+P+ N WT + + E +T+GV
Sbjct: 360 NPDTNTWTSLERMNESRSTLGV 381
Score = 42.0 bits (97), Expect = 0.002
Identities = 29/98 (29%), Positives = 43/98 (43%), Gaps = 9/98 (9%)
Query: 318 LVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQND 377
+ VGG G++ LS Y +N W+ M AV+D +LYV GG +
Sbjct: 481 IFVVGGHNGVSH--LSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSS 538
Query: 378 ARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLS 415
N + +YDP +TW+ A M R +F L+
Sbjct: 539 YLNTVQ-------KYDPISDTWLDSAGMIYCRCNFGLT 569
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 247 bits (631), Expect = 2e-65
Identities = 164/574 (28%), Positives = 270/574 (47%), Gaps = 23/574 (4%)
Query: 63 LSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSIQR---VDLNDISPL 119
+S+MRQ LCD+V+ K HK V+ASCS YF+ + + S R V L+DI P
Sbjct: 82 MSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQ 141
Query: 120 GLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIA 179
L ++ +AYT ++ + + +++ AA LQ++ + C FL+ ++ NC+ + A
Sbjct: 142 ALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFA 201
Query: 180 ETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMK 239
+ +S + AA +++ +F++ A++++FM L +Q+ EL+ D L +PSE ++ +
Sbjct: 202 DAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLS 261
Query: 240 WLEFD-QKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYHLLP 298
W++ D R ++ L+ +R +S L+ +V + + DC LL++A+ +HLLP
Sbjct: 262 WVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLP 321
Query: 299 YHQNTLQSRRTRIR---GGCRVLVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKS 355
+ L + RTR R G VL VGG G Y + W + M +
Sbjct: 322 EQRGVLGTSRTRPRRCEGAGPVLFAVGG--GSLFAIHGDCEAYDTRTDRWHVVASMSTRR 379
Query: 356 FNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLS 415
VA + LY GG D ++ YDP NTW SM +R+ ++
Sbjct: 380 ARVGVAAVGNRLYAVGGYD-------GTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVA 432
Query: 416 VFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYI 475
+GL+Y+AGG + L S E Y P T W + R A DG + GGY
Sbjct: 433 ALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYD 492
Query: 476 ANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTV 535
++++ +V Y+P + W + ++ + R L +YV GG+ + +V
Sbjct: 493 SSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGND-----GTSCLNSV 547
Query: 536 ECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWT 595
E YSP G W AP+ + ST + A+ G Y VGG N+G I+ ++P N+W
Sbjct: 548 ERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGG-NDGSSSLNS-IEKYNPRTNKWV 605
Query: 596 EDDELPEATVGVSCCTLSMPNNVTRESRASSVSS 629
+ V L + N S SVSS
Sbjct: 606 AASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSS 639
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 241 bits (614), Expect = 2e-63
Identities = 157/543 (28%), Positives = 261/543 (48%), Gaps = 24/543 (4%)
Query: 60 LEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSIQR---VDLNDI 116
LE ++ +R+ LCD+V+ K H+ ++++CS YF + + + R V + DI
Sbjct: 55 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDI 114
Query: 117 SPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVV 176
+ +I +AYT ++T+ + +++ AA LQ+ + + C +FL R++ NC+ +
Sbjct: 115 DERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIR 174
Query: 177 NIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSEIVAFQI 236
A+T+S + A KF + NF E ES++FM L Q+ +++ D+L + SE F
Sbjct: 175 AFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNA 234
Query: 237 AMKWLEFD-QKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYH 295
M W+++ Q+R +L ++R +S + LV V S P + D +C L+ +A NY
Sbjct: 235 VMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYL 294
Query: 296 LLPYHQNTLQSRRTRIRGGCR---VLVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMP 352
LLP + +Q RTR R R VL VGG + ++S Y N W + M
Sbjct: 295 LLPQERPLMQGPRTRPRKPIRCGEVLFAVGG--WCSGDAISSVERYDPQTNEWRMVASMS 352
Query: 353 AKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTW-IHLASMNQKRTH 411
+ V+V+D LY GG D + N + RYDP+ N W +A + RT
Sbjct: 353 KRRCGVGVSVLDDLLYAVGGHDGSSYLNSVE-------RYDPKTNQWSSDVAPTSTCRTS 405
Query: 412 FSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVT 471
++V G +YA GG++ L +E Y P N+W + R A AV G +
Sbjct: 406 VGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAV 465
Query: 472 GGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVD 531
GG + +V Y+P + W + + T R D +Y +GG R + +
Sbjct: 466 GGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGG-----RDDTTE 520
Query: 532 VLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPEL 591
+ + E Y+P T QWS + S G++ ++G+ VGG++ Y K I+ F P+
Sbjct: 521 LSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFD--GTTYLKTIEVFDPDA 578
Query: 592 NEW 594
N W
Sbjct: 579 NTW 581
Score = 109 bits (273), Expect = 7e-24
Identities = 56/177 (31%), Positives = 91/177 (51%), Gaps = 9/177 (5%)
Query: 318 LVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQND 377
L VGG+ G++ ++ Y EN W+++ M + VAV+ GFLY GG D
Sbjct: 415 LYAVGGQDGVSCLNIVER--YDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTS 472
Query: 378 ARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLE 437
N + RY+P+ N W +A M +R H +V+ ++YA GGR+ L+S E
Sbjct: 473 PLNTVE-------RYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAE 525
Query: 438 CYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQ 494
Y P TNQW P + R AV +G+++ GG+ Y +++ +DP +++W+
Sbjct: 526 RYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWR 582
Score = 57.0 bits (136), Expect = 5e-08
Identities = 43/149 (28%), Positives = 67/149 (44%), Gaps = 9/149 (6%)
Query: 466 GRVL-VTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLG 524
G VL GG+ + SV YDP ++ W+ + ++S R L D +Y +GG
Sbjct: 317 GEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGS 376
Query: 525 PRGERVDVLTVECYSPATGQWSY-AAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKC 583
+ +VE Y P T QWS AP ++ GV+ L G Y VGG +
Sbjct: 377 SY-----LNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGG--QDGVSCLNI 429
Query: 584 IQCFSPELNEWTEDDELPEATVGVSCCTL 612
++ + P+ N+WT + +GV+ L
Sbjct: 430 VERYDPKENKWTRVASMSTRRLGVAVAVL 458
Score = 37.7 bits (86), Expect = 0.033
Identities = 31/100 (31%), Positives = 41/100 (41%), Gaps = 13/100 (13%)
Query: 314 GCRV----LVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYV 369
GC V + VGGR TE LS Y N WS + M ++ +AV++G L
Sbjct: 501 GCAVYQDMIYAVGGRDDTTE--LSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMA 558
Query: 370 AGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKR 409
GG D + +DP NTW MN +R
Sbjct: 559 VGGFDGTTYLKTIEV-------FDPDANTWRLYGGMNYRR 591
>gi|226442729 kelch-like 15 [Homo sapiens]
Length = 604
Score = 234 bits (598), Expect = 1e-61
Identities = 149/588 (25%), Positives = 284/588 (48%), Gaps = 32/588 (5%)
Query: 62 GLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYF---YNILKKDPSIQRVDLNDISP 118
G + +E L D+ + + F HK+++A+ S+YF + ++ ++ L ++
Sbjct: 20 GFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTA 79
Query: 119 LGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNI 178
G + V+ + Y G + LS+ T+ I+ AA+Y+Q+ +VK C FL+ ++ +ENC ++ +
Sbjct: 80 TGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRL 139
Query: 179 AETY--SLKNAKAAAQKFIRDNFLEFAESDQFMK-LTFEQINELLIDDDLQLPSEIVAFQ 235
+ + +++ + F+ DNF+ F+ L+FE++ L +D L EI ++
Sbjct: 140 LDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYE 199
Query: 236 IAMKWLEFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYH 295
WL D++R ++ ++ NIRF ++ + V++ + A+NY
Sbjct: 200 AVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYF 259
Query: 296 LLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPENGWS-KLTEMPAK 354
+ Q L + +RIR G G + + S+ +L + P W + ++P +
Sbjct: 260 QNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVN-SKILLLKKPRVWWELEGPQVPLR 318
Query: 355 SFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSL 414
C+A+++ F+++ GGE+ + HA S RYDPR N+W+ +A M+ R+ F++
Sbjct: 319 P--DCLAIVNNFVFLLGGEELGP--DGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAV 374
Query: 415 SVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGY 474
V +YA GR + + S E Y + ++W+ P V + H V + ++ +TGG
Sbjct: 375 GVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGI 434
Query: 475 IANAYSRSVCAYDPASDS---------------WQELPNLSTPRGWHCAVTLSDRVYVMG 519
+++ S+ VC +DP+ + W+ ++ R +H ++ + ++YV G
Sbjct: 435 TSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFG 494
Query: 520 GSQLGPRG--ERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGE 577
G + R E + E Y+P T QW+ A + +G S GV+ L + ++GG
Sbjct: 495 GVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCY-N 553
Query: 578 KKYKKCIQCFSPELNEWTEDD--ELPEATVGVSCCTLSMPNNVTRESR 623
Y I F P+ N+W ED+ +P G+ C L P+ V E R
Sbjct: 554 GHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEVR 601
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 233 bits (595), Expect = 3e-61
Identities = 166/574 (28%), Positives = 266/574 (46%), Gaps = 29/574 (5%)
Query: 48 SELTDASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPS 107
SEL YG + ++R++ LCD+ + F H+ V+A+ YF+ + D
Sbjct: 18 SELPSRGYGV-----MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMM 72
Query: 108 IQRVD---LNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLI 164
+ D + + P L +I +AY G L + + S++ A +LQ+ ++ C FL
Sbjct: 73 ECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLR 132
Query: 165 REMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDD 224
+ +NC+ V AET AA FI +F+E + S++F+ L E + EL+ D+
Sbjct: 133 ERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDE 192
Query: 225 LQLPSEIVAFQIAMKWLEFD-QKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDAD 283
L + SE F+ A+ W+ +D ++R Y +LLSNIR Q L + VQ +
Sbjct: 193 LNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHK 252
Query: 284 CHRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDIL-YRDP- 341
C L+ +A +YHL+P + L + RTR R + + GL S +++ DP
Sbjct: 253 CRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPI 312
Query: 342 ENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIH 401
N W + M VAV++G LY GG D + +S Y+P +TW
Sbjct: 313 ANCWERCRPMTTARSRVGVAVVNGLLYAIGGYD-------GQLRLSTVEAYNPETDTWTR 365
Query: 402 LASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHAS 461
+ SMN KR+ V +G +Y GG + SL+S+E Y P T++W T + R
Sbjct: 366 VGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGV 425
Query: 462 AVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGS 521
V +GR+ V+GG+ SV Y+ + +W + R H A +L +++V GG
Sbjct: 426 TVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGY 485
Query: 522 QLGPRGERVDVLTV-ECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKY 580
+ L++ E YS QW P+ S + A GR Y VGG+ +G+
Sbjct: 486 ------DGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGY-DGQSNL 538
Query: 581 KKCIQCFSPELNEWTEDDELP--EATVGVSCCTL 612
++ + PE + WT + E VGV C L
Sbjct: 539 SS-VEMYDPETDCWTFMAPMACHEGGVGVGCIPL 571
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 232 bits (592), Expect = 7e-61
Identities = 157/578 (27%), Positives = 266/578 (46%), Gaps = 21/578 (3%)
Query: 45 CISSELTDA-SYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILK 103
C S E A ++ + + + LCD+++ + H+ V++S S+YF +
Sbjct: 145 CTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFT 204
Query: 104 KDPSIQR---VDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCS 160
D R + + + P L ++I YAYTG+L L I ++S A LQ+ +V+ C
Sbjct: 205 NDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACC 264
Query: 161 DFLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELL 220
FL++++ NC+ + + A+ + A + ++F+E + +F+ L +I +LL
Sbjct: 265 KFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLL 324
Query: 221 IDDDLQLPSEIVAFQIAMKWLEFD-QKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMM 279
DD+ +P+E + W+ D ++R K + LL+ IR ++ Q L + +V
Sbjct: 325 ASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNV-LFR 383
Query: 280 QDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIR-GGCRVLVTVGGRPGLTEKSLSRDILY 338
D +C +L+++AM YHLLP + LQS RT+ R L VGG + K + Y
Sbjct: 384 DDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMD--STKGATSIEKY 441
Query: 339 RDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNT 398
N W+ + M + VAV+D LYV GG D N + C Y+P+ T
Sbjct: 442 DLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVE------C-YNPKTKT 494
Query: 399 WIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCC 458
W + M+ R ++V G +YA GG + L ++E + P QW + R
Sbjct: 495 WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRST 554
Query: 459 HASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVM 518
AV G++ GG ++ +SV +DP ++ W +S RG T + +Y +
Sbjct: 555 VGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAI 614
Query: 519 GGSQLGPRGERVDVLT--VECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEG 576
GG P L+ VE Y P T W+ A + + GV L + Y VGG++
Sbjct: 615 GGHD-APASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYD-- 671
Query: 577 EKKYKKCIQCFSPELNEWTEDDELPEATVGVSCCTLSM 614
+ Y ++ + P+ NEWT+ L G T+ +
Sbjct: 672 GQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 709
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 232 bits (592), Expect = 7e-61
Identities = 157/578 (27%), Positives = 266/578 (46%), Gaps = 21/578 (3%)
Query: 45 CISSELTDA-SYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILK 103
C S E A ++ + + + LCD+++ + H+ V++S S+YF +
Sbjct: 191 CTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFT 250
Query: 104 KDPSIQR---VDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCS 160
D R + + + P L ++I YAYTG+L L I ++S A LQ+ +V+ C
Sbjct: 251 NDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACC 310
Query: 161 DFLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELL 220
FL++++ NC+ + + A+ + A + ++F+E + +F+ L +I +LL
Sbjct: 311 KFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLL 370
Query: 221 IDDDLQLPSEIVAFQIAMKWLEFD-QKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMM 279
DD+ +P+E + W+ D ++R K + LL+ IR ++ Q L + +V
Sbjct: 371 ASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNV-LFR 429
Query: 280 QDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIR-GGCRVLVTVGGRPGLTEKSLSRDILY 338
D +C +L+++AM YHLLP + LQS RT+ R L VGG + K + Y
Sbjct: 430 DDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMD--STKGATSIEKY 487
Query: 339 RDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNT 398
N W+ + M + VAV+D LYV GG D N + C Y+P+ T
Sbjct: 488 DLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVE------C-YNPKTKT 540
Query: 399 WIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCC 458
W + M+ R ++V G +YA GG + L ++E + P QW + R
Sbjct: 541 WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRST 600
Query: 459 HASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVM 518
AV G++ GG ++ +SV +DP ++ W +S RG T + +Y +
Sbjct: 601 VGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAI 660
Query: 519 GGSQLGPRGERVDVLT--VECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEG 576
GG P L+ VE Y P T W+ A + + GV L + Y VGG++
Sbjct: 661 GGHD-APASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYD-- 717
Query: 577 EKKYKKCIQCFSPELNEWTEDDELPEATVGVSCCTLSM 614
+ Y ++ + P+ NEWT+ L G T+ +
Sbjct: 718 GQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 755
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 229 bits (583), Expect = 8e-60
Identities = 146/543 (26%), Positives = 270/543 (49%), Gaps = 27/543 (4%)
Query: 63 LSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPS---IQRVDLNDISPL 119
++++R + LCD++I + + H+ V+A+CS YF + D S +++++ D+
Sbjct: 40 MNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQ 99
Query: 120 GLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIA 179
L+ +I Y YT ++ ++ + ++ AA LQ+ + + C DFL ++ NC+ + A
Sbjct: 100 TLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFA 159
Query: 180 ETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMK 239
+ ++ + A + +F E ++F+ L+ +Q+ L+ D L + SE F+ +
Sbjct: 160 DVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVIS 219
Query: 240 WLEFDQK-RVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYHLLP 298
W+ ++++ R+++ A L+ ++R + LV V+ + + C L++AM YHLLP
Sbjct: 220 WINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLP 279
Query: 299 YHQNTL-QSRRTRIRGGC---RVLVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAK 354
Q L ++ RT+ R +V++ VGG+ K++ Y E+ W ++ E+P++
Sbjct: 280 LDQRLLIKNPRTKPRTPVSLPKVMIVVGGQ---APKAIRSVECYDFEEDRWDQIAELPSR 336
Query: 355 SFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSL 414
V M G +Y GG + V YD + W +ASM ++R+
Sbjct: 337 RCRAGVVFMAGHVYAVGGFN-------GSLRVRTVDVYDGVKDQWTSIASMQERRSTLGA 389
Query: 415 SVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGY 474
+V N L+YA GG + LAS+E Y TN+W P+ R V +G++ GGY
Sbjct: 390 AVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGY 449
Query: 475 --IANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDV 532
+ +V Y+PA++ W + ++ST R LS ++Y GG GP +
Sbjct: 450 DGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHD-GPLVRK--- 505
Query: 533 LTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELN 592
+VE Y P T W A + + AGV A++G Y+VGG ++G ++ ++P +
Sbjct: 506 -SVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLAS-VEYYNPVTD 562
Query: 593 EWT 595
+WT
Sbjct: 563 KWT 565
Score = 89.4 bits (220), Expect = 9e-18
Identities = 61/206 (29%), Positives = 97/206 (47%), Gaps = 10/206 (4%)
Query: 303 TLQSRRTRIRGGCR--VLVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCV 360
++Q RR+ + +L VGG G T L+ Y N W + M + + V
Sbjct: 379 SMQERRSTLGAAVLNDLLYAVGGFDGST--GLASVEAYSYKTNEWFFVAPMNTRRSSVGV 436
Query: 361 AVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGL 420
V++G LY GG D ++ +S +Y+P N WI++A M+ +R+ + V +G
Sbjct: 437 GVVEGKLYAVGGYD-----GASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQ 491
Query: 421 VYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAYS 480
+YA GG + S+E Y P TN W+ + + R +G + V GG +
Sbjct: 492 LYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNL 551
Query: 481 RSVCAYDPASDSWQELP-NLSTPRGW 505
SV Y+P +D W LP N+ST R +
Sbjct: 552 ASVEYYNPVTDKWTLLPTNMSTGRSY 577
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 227 bits (578), Expect = 3e-59
Identities = 156/559 (27%), Positives = 259/559 (46%), Gaps = 21/559 (3%)
Query: 64 SKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKD---PSIQRVDLNDISPLG 120
S ++Q+ LCD+++ + H+ V++S S+YF + D + + + I P
Sbjct: 204 SYLKQQQ-LCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNA 262
Query: 121 LATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIAE 180
L ++ +AYTG L L TI ++++AA LQ+ +V++C FL++ + NC+ + A+
Sbjct: 263 LWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFAD 322
Query: 181 TYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMKW 240
A + +N +E + +F+ L E++++LL DD+ +P E F M W
Sbjct: 323 AQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMW 382
Query: 241 LEFD-QKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYHLLPY 299
+++D Q R + LL+ IR + Q L + +++ D +C +L+++AM YHLLP
Sbjct: 383 VKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQKLILEAMKYHLLPE 441
Query: 300 HQNTLQSRRTRIR-GGCRVLVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQ 358
+ +QS RT+ R L VGG K + Y N W + M +
Sbjct: 442 RRTLMQSPRTKPRKSTVGTLYAVGGMD--NNKGATTIEKYDLRTNLWIQAGMMNGRRLQF 499
Query: 359 CVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFN 418
VAV+D L+V GG D N + C Y+P+ TW L M+ R ++V
Sbjct: 500 GVAVIDDKLFVIGGRDGLKTLNTVE------C-YNPKTKTWTVLPPMSTHRHGLGVTVLE 552
Query: 419 GLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANA 478
G +YA GG + L ++E + P + QW + +AR A +G++ GG ++
Sbjct: 553 GPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSS 612
Query: 479 YSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLT--VE 536
S+ YDP ++ W + RG T +Y +GG P L VE
Sbjct: 613 CLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHD-APASNHCSRLLDYVE 671
Query: 537 CYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWTE 596
Y P T W+ APL + GV L R Y VGG++ + Y ++ + P+ NEWT+
Sbjct: 672 RYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYD--GQTYLNTMESYDPQTNEWTQ 729
Query: 597 DDELPEATVGVSCCTLSMP 615
L G + P
Sbjct: 730 MASLNIGRAGACVVVIKQP 748
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 224 bits (570), Expect = 2e-58
Identities = 145/543 (26%), Positives = 263/543 (48%), Gaps = 27/543 (4%)
Query: 63 LSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPS---IQRVDLNDISPL 119
++++R +N LCD+ I + H+ V+A+CS YF+ + + S +RV + ++
Sbjct: 50 MNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGW 109
Query: 120 GLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIA 179
L +I Y YT ++ ++ + ++ AA LQ+ + K C +FL ++ NC+ + A
Sbjct: 110 TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFA 169
Query: 180 ETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMK 239
+ ++ + A + +F + S++F+ L EQ+ L+ D L + SE F+ +
Sbjct: 170 DMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIA 229
Query: 240 WLEFDQK-RVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYHLLP 298
W+ D+ R ++ A L+ ++R + + LV V+ + + C L++AM YHLLP
Sbjct: 230 WVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLP 289
Query: 299 YHQNTL-QSRRTRIRGGC---RVLVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAK 354
Q L +S RTR+R +++V VGG+ K++ Y E W ++ E+P++
Sbjct: 290 TEQRILMKSVRTRLRTPMNLPKLMVVVGGQ---APKAIRSVECYDFKEERWHQVAELPSR 346
Query: 355 SFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSL 414
+ M G ++ GG + V YDP + W +A+M +R+
Sbjct: 347 RCRAGMVYMAGLVFAVGGFN-------GSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGA 399
Query: 415 SVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGY 474
+V NGL+YA GG + L+S+E Y +N+W P+ R V G + GGY
Sbjct: 400 AVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGY 459
Query: 475 --IANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDV 532
+ +V Y+ ++ W + +ST R L++ +Y +GG GP +
Sbjct: 460 DGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-GPLVRK--- 515
Query: 533 LTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELN 592
+VE Y P T W A + + AGV A++G Y+VGG ++G ++ ++P +
Sbjct: 516 -SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLAS-VEYYNPTTD 572
Query: 593 EWT 595
+WT
Sbjct: 573 KWT 575
Score = 90.5 bits (223), Expect = 4e-18
Identities = 54/194 (27%), Positives = 88/194 (45%), Gaps = 6/194 (3%)
Query: 420 LVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAY 479
L+ GG+ A ++ S+ECY +W L RC G V GG+ +
Sbjct: 312 LMVVVGGQ-APKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLR 370
Query: 480 SRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYS 539
R+V +YDP D W + N+ R A L+ +Y +GG G G + +VE Y+
Sbjct: 371 VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFD-GSTG----LSSVEAYN 425
Query: 540 PATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWTEDDE 599
+ +W + AP+ S+ GV + G Y VGG++ ++ ++C++ NEWT E
Sbjct: 426 IKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAE 485
Query: 600 LPEATVGVSCCTLS 613
+ G L+
Sbjct: 486 MSTRRSGAGVGVLN 499
Score = 83.6 bits (205), Expect = 5e-16
Identities = 55/198 (27%), Positives = 88/198 (44%), Gaps = 7/198 (3%)
Query: 317 VLVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQN 376
+L VGG G T LS Y N W + M + + V V+ G LY GG D
Sbjct: 405 LLYAVGGFDGST--GLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYD-- 460
Query: 377 DARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASL 436
++ +S Y+ N W ++A M+ +R+ + V N L+YA GG + S+
Sbjct: 461 ---GASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSV 517
Query: 437 ECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQEL 496
E Y P+TN W+ + + R +G + V GG + SV Y+P +D W +
Sbjct: 518 EVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVV 577
Query: 497 PNLSTPRGWHCAVTLSDR 514
+ + + VT+ D+
Sbjct: 578 SSCMSTGRSYAGVTVIDK 595
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 224 bits (570), Expect = 2e-58
Identities = 145/543 (26%), Positives = 263/543 (48%), Gaps = 27/543 (4%)
Query: 63 LSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPS---IQRVDLNDISPL 119
++++R +N LCD+ I + H+ V+A+CS YF+ + + S +RV + ++
Sbjct: 46 MNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGW 105
Query: 120 GLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIA 179
L +I Y YT ++ ++ + ++ AA LQ+ + K C +FL ++ NC+ + A
Sbjct: 106 TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFA 165
Query: 180 ETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMK 239
+ ++ + A + +F + S++F+ L EQ+ L+ D L + SE F+ +
Sbjct: 166 DMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIA 225
Query: 240 WLEFDQK-RVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYHLLP 298
W+ D+ R ++ A L+ ++R + + LV V+ + + C L++AM YHLLP
Sbjct: 226 WVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLP 285
Query: 299 YHQNTL-QSRRTRIRGGC---RVLVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAK 354
Q L +S RTR+R +++V VGG+ K++ Y E W ++ E+P++
Sbjct: 286 TEQRILMKSVRTRLRTPMNLPKLMVVVGGQ---APKAIRSVECYDFKEERWHQVAELPSR 342
Query: 355 SFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSL 414
+ M G ++ GG + V YDP + W +A+M +R+
Sbjct: 343 RCRAGMVYMAGLVFAVGGFN-------GSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGA 395
Query: 415 SVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGY 474
+V NGL+YA GG + L+S+E Y +N+W P+ R V G + GGY
Sbjct: 396 AVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGY 455
Query: 475 --IANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDV 532
+ +V Y+ ++ W + +ST R L++ +Y +GG GP +
Sbjct: 456 DGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-GPLVRK--- 511
Query: 533 LTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELN 592
+VE Y P T W A + + AGV A++G Y+VGG ++G ++ ++P +
Sbjct: 512 -SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLAS-VEYYNPTTD 568
Query: 593 EWT 595
+WT
Sbjct: 569 KWT 571
Score = 90.5 bits (223), Expect = 4e-18
Identities = 54/194 (27%), Positives = 88/194 (45%), Gaps = 6/194 (3%)
Query: 420 LVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAY 479
L+ GG+ A ++ S+ECY +W L RC G V GG+ +
Sbjct: 308 LMVVVGGQ-APKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLR 366
Query: 480 SRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYS 539
R+V +YDP D W + N+ R A L+ +Y +GG G G + +VE Y+
Sbjct: 367 VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFD-GSTG----LSSVEAYN 421
Query: 540 PATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWTEDDE 599
+ +W + AP+ S+ GV + G Y VGG++ ++ ++C++ NEWT E
Sbjct: 422 IKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAE 481
Query: 600 LPEATVGVSCCTLS 613
+ G L+
Sbjct: 482 MSTRRSGAGVGVLN 495
Score = 83.6 bits (205), Expect = 5e-16
Identities = 55/198 (27%), Positives = 88/198 (44%), Gaps = 7/198 (3%)
Query: 317 VLVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQN 376
+L VGG G T LS Y N W + M + + V V+ G LY GG D
Sbjct: 401 LLYAVGGFDGST--GLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYD-- 456
Query: 377 DARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASL 436
++ +S Y+ N W ++A M+ +R+ + V N L+YA GG + S+
Sbjct: 457 ---GASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSV 513
Query: 437 ECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQEL 496
E Y P+TN W+ + + R +G + V GG + SV Y+P +D W +
Sbjct: 514 EVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVV 573
Query: 497 PNLSTPRGWHCAVTLSDR 514
+ + + VT+ D+
Sbjct: 574 SSCMSTGRSYAGVTVIDK 591
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 220 bits (561), Expect = 3e-57
Identities = 149/532 (28%), Positives = 248/532 (46%), Gaps = 20/532 (3%)
Query: 90 VMASCSEYFYNILKKDPSIQR---VDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISA 146
V++S S+YF + D R + + + P L ++I YAYTG+L L I ++S
Sbjct: 176 VLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLST 235
Query: 147 AVYLQIHTLVKMCSDFLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESD 206
A LQ+ +V+ C FL++++ NC+ + + A+ + A + ++F+E +
Sbjct: 236 ACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQ 295
Query: 207 QFMKLTFEQINELLIDDDLQLPSEIVAFQIAMKWLEFD-QKRVKYAADLLSNIRFGTISA 265
+F+ L +I +LL DD+ +P+E + W+ D ++R K + LL+ IR ++
Sbjct: 296 EFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAP 355
Query: 266 QDLVNYVQSVPRMMQDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIR-GGCRVLVTVGGR 324
Q L + +V D +C +L+++AM YHLLP + LQS RT+ R L VGG
Sbjct: 356 QFLADMENNV-LFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGM 414
Query: 325 PGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKH 384
+ K + Y N W+ + M + VAV+D LYV GG D N +
Sbjct: 415 D--STKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVE- 471
Query: 385 AVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTN 444
C Y+P+ TW + M+ R ++V G +YA GG + L ++E + P
Sbjct: 472 -----C-YNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 525
Query: 445 QWQPKTPLEVARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRG 504
QW + R AV G++ GG ++ +SV +DP ++ W +S RG
Sbjct: 526 QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRG 585
Query: 505 WHCAVTLSDRVYVMGGSQLGPRGERVDVLT--VECYSPATGQWSYAAPLQVGVSTAGVSA 562
T + +Y +GG P L+ VE Y P T W+ A + + GV
Sbjct: 586 GVGVTTWNGLLYAIGGHD-APASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCL 644
Query: 563 LHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWTEDDELPEATVGVSCCTLSM 614
L + Y VGG++ + Y ++ + P+ NEWT+ L G T+ +
Sbjct: 645 LGDKLYAVGGYD--GQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 694
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 214 bits (544), Expect = 3e-55
Identities = 155/558 (27%), Positives = 249/558 (44%), Gaps = 59/558 (10%)
Query: 54 SYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKD---PSIQR 110
++ L + +E LCD+++ H+ V+++ S+YF + D +
Sbjct: 163 NHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEE 222
Query: 111 VDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVE 170
V + + P L +++ YAYTG L L TI S+++AA LQ+ ++ +CS+FLI+++
Sbjct: 223 VRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPS 282
Query: 171 NCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSE 230
NC+ + + + A K+ ++F+E ++ +F+ L +I++LL DD+ +P E
Sbjct: 283 NCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDE 342
Query: 231 IVAFQIAMKWLEFD-QKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLV 289
F M+W+ D Q R LLS IR + Q L + +++ D +C +LL+
Sbjct: 343 ETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLM 401
Query: 290 DAMNYHLLPYHQNTLQSRRTRIR-GGCRVLVTVGGRPGLTEKSLSRDILYRDPENGWSKL 348
+AM YHLLP ++ +QS RT+ R L VGG + K + Y N W +
Sbjct: 402 EAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAM--KGTTTIEKYDLRTNSWLHI 459
Query: 349 TEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQA-------------------KHA---- 385
M + VAV+D LYV GG D N +H
Sbjct: 460 GTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVA 519
Query: 386 -----------------VSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRN 428
++ R+DP W ++ASM+ R+ + N +YA GGR+
Sbjct: 520 TLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRD 579
Query: 429 AEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANA------YSRS 482
L S+E + P TN+W P+ R A +G + V GG+ A A S
Sbjct: 580 GSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDC 639
Query: 483 VCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPAT 542
V YDP DSW + LS PR L D++YV+GG + TVE Y
Sbjct: 640 VERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYD-----GHTYLNTVESYDAQR 694
Query: 543 GQWSYAAPLQVGVSTAGV 560
+W P+ +G + A V
Sbjct: 695 NEWKEEVPVNIGRAGACV 712
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 208 bits (529), Expect = 1e-53
Identities = 151/543 (27%), Positives = 242/543 (44%), Gaps = 59/543 (10%)
Query: 54 SYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKD---PSIQR 110
++ L + +E LCD+++ H+ V+++ S+YF + D +
Sbjct: 163 NHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEE 222
Query: 111 VDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVE 170
V + + P L +++ YAYTG L L TI S+++AA LQ+ ++ +CS+FLI+++
Sbjct: 223 VRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPS 282
Query: 171 NCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSE 230
NC+ + + + A K+ ++F+E ++ +F+ L +I++LL DD+ +P E
Sbjct: 283 NCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDE 342
Query: 231 IVAFQIAMKWLEFD-QKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLV 289
F M+W+ D Q R LLS IR + Q L + +++ D +C +LL+
Sbjct: 343 ETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLM 401
Query: 290 DAMNYHLLPYHQNTLQSRRTRIR-GGCRVLVTVGGRPGLTEKSLSRDILYRDPENGWSKL 348
+AM YHLLP ++ +QS RT+ R L VGG + K + Y N W +
Sbjct: 402 EAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAM--KGTTTIEKYDLRTNSWLHI 459
Query: 349 TEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQA-------------------KHA---- 385
M + VAV+D LYV GG D N +H
Sbjct: 460 GTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVA 519
Query: 386 -----------------VSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRN 428
++ R+DP W ++ASM+ R+ + N +YA GGR+
Sbjct: 520 TLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRD 579
Query: 429 AEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANA------YSRS 482
L S+E + P TN+W P+ R A +G + V GG+ A A S
Sbjct: 580 GSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDC 639
Query: 483 VCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPAT 542
V YDP DSW + LS PR L D++YV+GG + TVE Y
Sbjct: 640 VERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYD-----GHTYLNTVESYDAQR 694
Query: 543 GQW 545
+W
Sbjct: 695 NEW 697
Score = 34.3 bits (77), Expect = 0.36
Identities = 22/82 (26%), Positives = 35/82 (42%), Gaps = 2/82 (2%)
Query: 534 TVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELNE 593
T+E Y T W + + GV+ + + Y+VGG +G K ++CF+P
Sbjct: 445 TIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGG-RDGLKTLNT-VECFNPVGKI 502
Query: 594 WTEDDELPEATVGVSCCTLSMP 615
WT + G+ TL P
Sbjct: 503 WTVMPPMSTHRHGLGVATLEGP 524
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 205 bits (522), Expect = 9e-53
Identities = 147/574 (25%), Positives = 263/574 (45%), Gaps = 35/574 (6%)
Query: 53 ASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSIQR-- 110
+S+ N+L+ ++ R D++I + K F H++V+++CS YF + D R
Sbjct: 46 SSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREM 105
Query: 111 -VDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSV 169
V++N I + + Y YTGK+ ++ + + + QI L C+ FL ++
Sbjct: 106 LVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDP 165
Query: 170 ENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPS 229
NC+ + A+T+SLK + F F + ++ ++F++L +++ + + D+L +
Sbjct: 166 CNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGK 225
Query: 230 EIVAFQIAMKWL--EFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRL 287
E + F+ M+W+ D +R +LL+++R + V V+ + +C++L
Sbjct: 226 EEMVFEAVMRWVYRAVDLRR-PLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQL 284
Query: 288 LVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPENG-WS 346
L +A YH+L + ++R R G V+V VGG + +L Y DP G W
Sbjct: 285 LHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECY-DPVTGEWK 343
Query: 347 KLTEMPAKSFNQ-CVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASM 405
L ++P + ++ V + + V+GG + + Y+ + N WI +AS+
Sbjct: 344 SLAKLPEFTKSEYAVCALRNDILVSGGRINS----------RDVWIYNSQLNIWIRVASL 393
Query: 406 NQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVAD 465
N+ R ++V G VY GG + + L+S+ECY +N+W PL+ A A
Sbjct: 394 NKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCV 453
Query: 466 GRVLVT-GGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHC--AVTLSDRVYVMGGSQ 522
G++ V GG N S V +YDP ++SW L + P C AV+L++ +YV GG
Sbjct: 454 GKLFVIGGGPDDNTCSDKVQSYDPETNSW--LLRAAIPIAKRCITAVSLNNLIYVAGGL- 510
Query: 523 LGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKK 582
+ CY P W + G+S +G+ Y++GG E +
Sbjct: 511 ---------TKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEA-TD 560
Query: 583 CIQCFSPELNEWTEDDELPEATVGVSCCTLSMPN 616
I C+ P + T +P C T+ N
Sbjct: 561 TILCYDPATSIITGVAAMPRPVSYHGCVTIHRYN 594
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 204 bits (519), Expect = 2e-52
Identities = 146/572 (25%), Positives = 261/572 (45%), Gaps = 38/572 (6%)
Query: 49 ELTDASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSI 108
E TD + +L+ L++ R+ DL I + + F+VH++V+ASCS YF +++++ S+
Sbjct: 305 EFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR--SV 362
Query: 109 Q----------RVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKM 158
Q + L+++ L ++ + YTG L + +++ AA Q HT K+
Sbjct: 363 QDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKV 422
Query: 159 CSDFLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINE 218
C FL ++++ NC+ V+ +AE A+ F F E A ++ + ++ +
Sbjct: 423 CVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIA 482
Query: 219 LLIDDDLQLPSEIVAFQIAMKWLEFD-QKRVKYAADLLSNIRFGTISAQDLVNYVQSVPR 277
+ +D L +E + ++ +KW++ D R +YAA+LL+ +R I L+N V +
Sbjct: 483 YVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEEL 542
Query: 278 MMQDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIR---GGCRVLVTVGGRP--GLTEKSL 332
+ C L+ +A YH+LP+ + +Q+ RTR R G V+V VGGR G+T++SL
Sbjct: 543 IKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSL 602
Query: 333 SRDILYRDPENGWSKLTEMP--AKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFC 390
+ N W L +P + F V+ D +Y++GG + +++
Sbjct: 603 VAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDN-IYLSGGMESG-------VTLADVW 654
Query: 391 RYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKT 450
Y + W ++ M R + V++G +Y GG G++ +E Y TNQW+
Sbjct: 655 CYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVA 714
Query: 451 PLEVARCCHASAVADGRVLVTGGYIANAYSRSVC-AYDPASDSWQELPNLSTPRGWHCAV 509
PL A A+ V G++ V GG + V +Y P +++W + + + AV
Sbjct: 715 PLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAV 774
Query: 510 TLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYL 569
TL+ V+++GG+ Y P G + L G+ Y
Sbjct: 775 TLNGFVFILGGAY---------ARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYA 825
Query: 570 VGGWNEGEKKYKKCIQCFSPELNEWTEDDELP 601
GG E ++ + P N WT +P
Sbjct: 826 TGGIVSSEGPALGNMEAYEPTTNTWTLLPHMP 857
Score = 59.7 bits (143), Expect = 8e-09
Identities = 44/180 (24%), Positives = 75/180 (41%), Gaps = 14/180 (7%)
Query: 343 NGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHL 402
N W + +P + V G +YV GG N+A A Y P+ NTW +
Sbjct: 708 NQWEAVAPLPKAVHSAAATVCGGKIYVFGGV------NEAGRAAGVLQSYVPQTNTWSFI 761
Query: 403 ASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASA 462
S + NG V+ GG A + Y P + + +R ++
Sbjct: 762 ESPMIDNKYAPAVTLNGFVFILGGAYARATTI----YDPEKGNIKAGPNMNHSRQFCSAV 817
Query: 463 VADGRVLVTGGYIANAYSR--SVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGG 520
V DG++ TGG +++ ++ AY+P +++W LP++ P H V + + Y+ G
Sbjct: 818 VLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVI--KKYIQSG 875
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 204 bits (519), Expect = 2e-52
Identities = 146/572 (25%), Positives = 261/572 (45%), Gaps = 38/572 (6%)
Query: 49 ELTDASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSI 108
E TD + +L+ L++ R+ DL I + + F+VH++V+ASCS YF +++++ S+
Sbjct: 305 EFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR--SV 362
Query: 109 Q----------RVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKM 158
Q + L+++ L ++ + YTG L + +++ AA Q HT K+
Sbjct: 363 QDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKV 422
Query: 159 CSDFLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINE 218
C FL ++++ NC+ V+ +AE A+ F F E A ++ + ++ +
Sbjct: 423 CVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIA 482
Query: 219 LLIDDDLQLPSEIVAFQIAMKWLEFD-QKRVKYAADLLSNIRFGTISAQDLVNYVQSVPR 277
+ +D L +E + ++ +KW++ D R +YAA+LL+ +R I L+N V +
Sbjct: 483 YVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEEL 542
Query: 278 MMQDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIR---GGCRVLVTVGGRP--GLTEKSL 332
+ C L+ +A YH+LP+ + +Q+ RTR R G V+V VGGR G+T++SL
Sbjct: 543 IKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSL 602
Query: 333 SRDILYRDPENGWSKLTEMP--AKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFC 390
+ N W L +P + F V+ D +Y++GG + +++
Sbjct: 603 VAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDN-IYLSGGMESG-------VTLADVW 654
Query: 391 RYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKT 450
Y + W ++ M R + V++G +Y GG G++ +E Y TNQW+
Sbjct: 655 CYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVA 714
Query: 451 PLEVARCCHASAVADGRVLVTGGYIANAYSRSVC-AYDPASDSWQELPNLSTPRGWHCAV 509
PL A A+ V G++ V GG + V +Y P +++W + + + AV
Sbjct: 715 PLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAV 774
Query: 510 TLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYL 569
TL+ V+++GG+ Y P G + L G+ Y
Sbjct: 775 TLNGFVFILGGAY---------ARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYA 825
Query: 570 VGGWNEGEKKYKKCIQCFSPELNEWTEDDELP 601
GG E ++ + P N WT +P
Sbjct: 826 TGGIVSSEGPALGNMEAYEPTTNTWTLLPHMP 857
Score = 59.7 bits (143), Expect = 8e-09
Identities = 44/180 (24%), Positives = 75/180 (41%), Gaps = 14/180 (7%)
Query: 343 NGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHL 402
N W + +P + V G +YV GG N+A A Y P+ NTW +
Sbjct: 708 NQWEAVAPLPKAVHSAAATVCGGKIYVFGGV------NEAGRAAGVLQSYVPQTNTWSFI 761
Query: 403 ASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASA 462
S + NG V+ GG A + Y P + + +R ++
Sbjct: 762 ESPMIDNKYAPAVTLNGFVFILGGAYARATTI----YDPEKGNIKAGPNMNHSRQFCSAV 817
Query: 463 VADGRVLVTGGYIANAYSR--SVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGG 520
V DG++ TGG +++ ++ AY+P +++W LP++ P H V + + Y+ G
Sbjct: 818 VLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVI--KKYIQSG 875
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 203 bits (516), Expect = 4e-52
Identities = 130/545 (23%), Positives = 254/545 (46%), Gaps = 15/545 (2%)
Query: 54 SYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSIQR--- 110
++ ++L ++ +R+ N LCD+ + + K F H+ V+A+CS+YF + + S +
Sbjct: 14 THAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPY 73
Query: 111 VDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVE 170
VD+ ++ + ++ + YT + +++ + ++ AA LQ+ + + C +FL ++
Sbjct: 74 VDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPS 133
Query: 171 NCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSE 230
NC+ + + AET++ + AA+ F + +F E + ++F+ L+ ++ +L+ D++Q+ SE
Sbjct: 134 NCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSE 193
Query: 231 IVAFQIAMKWLEFDQK-RVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLV 289
F+ + W++ +K R + +LL +R ++ + + + + + P + C L+
Sbjct: 194 EPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVD 253
Query: 290 DAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPENGWSKLT 349
+A +HL P ++ +Q RTR R G ++ V G G + + Y WS L
Sbjct: 254 EAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLP 313
Query: 350 EMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKR 409
+ K + +YV GG D +R + + D W +A MN +R
Sbjct: 314 SITRKRRYVASVSLHDRIYVIGGYD-GRSRLSSVECLDYTADED---GVWYSVAPMNVRR 369
Query: 410 THFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVL 469
+ ++Y +GG + S+E Y P+ +QW ++ AR VA G +
Sbjct: 370 GLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIY 429
Query: 470 VTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGER 529
GGY SV YDP + W + ++T R L+D +YV+GG
Sbjct: 430 CLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFD-----GT 484
Query: 530 VDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSP 589
+ +VE Y+ T W+ + G + L GR Y + G++ I+C+ P
Sbjct: 485 AHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYD--GNSLLSSIECYDP 542
Query: 590 ELNEW 594
++ W
Sbjct: 543 IIDSW 547
>gi|23397572 kelch-like 34 [Homo sapiens]
Length = 644
Score = 203 bits (516), Expect = 4e-52
Identities = 162/622 (26%), Positives = 265/622 (42%), Gaps = 69/622 (11%)
Query: 54 SYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSIQR--- 110
++G LL G +R E FLCD+ + T+ F H+S++A S+YF + K R
Sbjct: 10 AHGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARV 69
Query: 111 VDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVE 170
+ L+ S GL ++ + YT L+LS+ T+ + AA YLQ+ + +C +L R+++ E
Sbjct: 70 IHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPE 129
Query: 171 NCMYVVNIAETYSLKNAKAAAQKFIRDNFLEF----AESDQFMKLTFEQINELLIDDDLQ 226
NC + N+A + L + AA++ I + E A ++L + +L D+
Sbjct: 130 NCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVA 189
Query: 227 LPSEIVAFQIAMKWL--EFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADC 284
E +A+ WL E +R+ + +LL +RFG + A D++ V S ++ A
Sbjct: 190 RVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPA-DVLRRVYSGSGLVLPARV 248
Query: 285 HRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGR-------------------- 324
L++ A+NYH P Q +Q +T IR ++ VGGR
Sbjct: 249 KGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARGQ 308
Query: 325 -----PGLTEKSLSRD------------ILYRDPENGWSKLTEMPAKSFNQCVAVMDGFL 367
P E+ L + + + + W LT++P V FL
Sbjct: 309 VAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNFL 368
Query: 368 YVAGGEDQNDA-----RNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVY 422
+V GGE + + + ++ + RYDPRF+ W + +M + R HF +
Sbjct: 369 FVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLL 428
Query: 423 AAGGRNAEGS-LASLECYVPSTNQWQPKTPLEVARCCHASAVAD-GRVLVTGGYIANAYS 480
A GG A G LAS+E Y ++W L A HA AV D G V ++GG
Sbjct: 429 AVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEG 488
Query: 481 -----RSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTV 535
R + P W + + T R H L V+ G + P E +
Sbjct: 489 GASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLG-RYEPFSE------I 541
Query: 536 ECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGG--WNEGEKKYKKCIQCFSPELNE 593
E Y P QW+ PL G++ + A L+GG W + + + + + +L+
Sbjct: 542 ERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLDR 601
Query: 594 WTE-DDELPEATVGVSCCTLSM 614
W + LP A G+ C L +
Sbjct: 602 WEDIGCALPWAWSGLRCAVLQL 623
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 201 bits (510), Expect = 2e-51
Identities = 138/568 (24%), Positives = 259/568 (45%), Gaps = 26/568 (4%)
Query: 61 EGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKK---DPSIQRVDLNDIS 117
E +++R E LCD+VI F HK+++ SCS YF + + + ++ IS
Sbjct: 27 EIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGIS 86
Query: 118 PLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVN 177
P + +I YAYT + ++ + +++AA I +V+ C +FL E+ ++NC+ +
Sbjct: 87 PDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICK 146
Query: 178 IAETYSLKNAKAAAQKFIRDNFLEFAE-SDQFMKLTFEQINELLIDDDLQLPSEIVAFQI 236
+ Y + A FI NF E + S +F++L+ ++ +++ D+L + E F+
Sbjct: 147 FTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEA 206
Query: 237 AMKWLEFD-QKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLVDAM--- 292
+KW+ D Q R ++ + LL +R + A+ +N V+ + +C ++++A+
Sbjct: 207 ILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAM 266
Query: 293 -NYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPENGWSKLT-E 350
+ ++ + + TR R +L +GG G + + Y + W +T E
Sbjct: 267 YDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIE--AYDARADRWVNVTCE 324
Query: 351 MPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRT 410
+ A + G++Y+ GG D D N K R+DP TW +A M+ +R
Sbjct: 325 EESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVK-------RFDPVKKTWHQVAPMHSRRC 377
Query: 411 HFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLV 470
+ S++V +YA GG + L + E Y P TNQW P+ R ++ G+V +
Sbjct: 378 YVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYI 437
Query: 471 TGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERV 530
GG+ N + Y+ S+ W + + + R + + VY +GG R
Sbjct: 438 CGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANR---- 493
Query: 531 DVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPE 590
+ + E YSP W + S G+ + ++VGG+N + ++C+ +
Sbjct: 494 -LRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFN--VECYDEK 550
Query: 591 LNEWTEDDELPEATVGVSCCTLSMPNNV 618
+EW + ++ +SCC + NV
Sbjct: 551 TDEWYDAHDMSIYRSALSCCVVPGLANV 578
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 199 bits (507), Expect = 5e-51
Identities = 143/561 (25%), Positives = 252/561 (44%), Gaps = 29/561 (5%)
Query: 63 LSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSIQR---VDLNDISPL 119
L + + LCD+ + +K HK V+A YF + + + + +++ D
Sbjct: 57 LLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGD 116
Query: 120 GLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIA 179
+ ++ + Y+ +LTL++ + ++ AA LQ+ + + C +++ NC+ V A
Sbjct: 117 AIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFA 176
Query: 180 ETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMK 239
E+++ + A ++ D+F E E + F+ ++ + +++LL DL + +E + A+K
Sbjct: 177 ESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIK 236
Query: 240 WLEFD-QKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYHL-- 296
WL + Q K+ + L+ +R + L+ V + Q+ C LL +A NYHL
Sbjct: 237 WLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHL 296
Query: 297 ----LPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMP 352
+P + ++++ + G VL VGGR G + S + Y +N W EM
Sbjct: 297 SSRAVPDFEYSIRTTPRKHTAG--VLFCVGGRGGSGDPFRSIE-CYSINKNSWFFGPEMN 353
Query: 353 AKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHF 412
++ + V ++G +Y GG D N+ + + +DP N W+ ASMN KR
Sbjct: 354 SRRRHVGVISVEGKVYAVGGHDGNE-------HLGSMEMFDPLTNKWMMKASMNTKRRGI 406
Query: 413 SLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTG 472
+L+ G +YA GG + +E Y ++QW P+ R S V G
Sbjct: 407 ALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVG 466
Query: 473 GYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDV 532
G A SV YDP D W E+ + R + L +YV+GG + +
Sbjct: 467 GNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFD-----DNSPL 521
Query: 533 LTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELN 592
+VE Y P + +W Y A L G++ + G+ + VGG N Y ++ F P LN
Sbjct: 522 SSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHN--GNAYLNTVEAFDPVLN 579
Query: 593 EWTEDDELP--EATVGVSCCT 611
W + A GV+ C+
Sbjct: 580 RWELVGSVSHCRAGAGVAVCS 600
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 198 bits (503), Expect = 1e-50
Identities = 138/552 (25%), Positives = 259/552 (46%), Gaps = 38/552 (6%)
Query: 63 LSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSIQ----RVDLNDISP 118
++ MR++ LCD+++ + + H+ V+A+ S +F+N++ ++ V+L D P
Sbjct: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAAS-HFFNLMFTTNMLESKSFEVELKDAEP 92
Query: 119 LGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNI 178
+ ++ +AYT +++++ + S++ AA QI + KMC DFL ++ NC+ + +
Sbjct: 93 DIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVL 152
Query: 179 AETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAM 238
AE KA A FI +F E ++D+F++L +++ LL D L + +E + A+
Sbjct: 153 AECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAV 212
Query: 239 KWLEFDQ-KRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYHLL 297
+WL++D+ R + D+L+ +RF IS L VQ+ P + + +C ++++ M YHLL
Sbjct: 213 RWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLL 272
Query: 298 -PYHQNTL--QSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPEN-GWSKLTEMPA 353
P + L +R R + R+ + G +P + Y +P++ W+ +
Sbjct: 273 SPEDREELVDGTRPRRKKHDYRIALFGGSQP--------QSCRYFNPKDYSWTDIRCPFE 324
Query: 354 KSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFS 413
K + D +Y+ GG + Y+ ++W R +
Sbjct: 325 KRRDAACVFWDNVVYILGGSQ--------LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLA 376
Query: 414 LSVFNGLVYAAGGRNAEGS-LASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTG 472
G +Y +GG S L ECY T W K + RC H A+G + V G
Sbjct: 377 ACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCG 436
Query: 473 GYIANAYSRSVC----AYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGE 528
G + N S V YDPA+++W EL + R H V + D+++ +GG Q G G
Sbjct: 437 GSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGG-QNGLGG- 494
Query: 529 RVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFS 588
+ VE Y +W +P+ T +A+ Y++ G+ +G + ++ ++
Sbjct: 495 ---LDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGF-QGVGRLGHILE-YN 549
Query: 589 PELNEWTEDDEL 600
E ++W + ++
Sbjct: 550 TETDKWVANSKV 561
Score = 77.4 bits (189), Expect = 4e-14
Identities = 59/225 (26%), Positives = 99/225 (44%), Gaps = 6/225 (2%)
Query: 390 CRY-DPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQP 448
CRY +P+ +W + +KR + ++ +VY GG + ++CY + W
Sbjct: 306 CRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLF-PIKRMDCYNVVKDSWYS 364
Query: 449 KTPLEVARCCHASAVADGRVLVTGGY-IANAYSRSVCAYDPASDSWQELPNLSTPRGWHC 507
K R A+ A+G++ +GG + N+ YD ++SW P++ T R H
Sbjct: 365 KLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHG 424
Query: 508 AVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRA 567
V + +YV GGS LG + + E Y PAT W+ P+ G+ + +
Sbjct: 425 MVEANGLIYVCGGS-LGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKI 483
Query: 568 YLVGGWNEGEKKYKKCIQCFSPELNEWTEDDELPEATVGVSCCTL 612
+ VGG N G ++ + +LNEW +P V V C +
Sbjct: 484 FAVGGQN-GLGGLDN-VEYYDIKLNEWKMVSPMPWKGVTVKCAAV 526
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,581,971
Number of Sequences: 37866
Number of extensions: 1044283
Number of successful extensions: 3574
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 167
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 2142
Number of HSP's gapped (non-prelim): 355
length of query: 634
length of database: 18,247,518
effective HSP length: 108
effective length of query: 526
effective length of database: 14,157,990
effective search space: 7447102740
effective search space used: 7447102740
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.