Search of human proteins with 4758224

Search of human proteins with 4758224

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4758224 integral membrane protein 2A [Homo sapiens]
         (263 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4758224 integral membrane protein 2A [Homo sapiens]                527   e-150
gi|11527402 integral membrane protein 2B [Homo sapiens]               201   4e-52
gi|13569885 integral membrane protein 2C isoform 1 [Homo sapiens]     175   4e-44
gi|60302912 integral membrane protein 2C isoform 3 [Homo sapiens]     159   2e-39
gi|60302914 integral membrane protein 2C isoform 2 [Homo sapiens]     119   4e-27
gi|197209974 coiled-coil and C2 domain containing 2A isoform a [...    30   1.6  
gi|197209817 coiled-coil and C2 domain containing 2A isoform b [...    30   1.6  
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom...    29   3.7  
gi|40254988 LSM domain containing 1 [Homo sapiens]                     28   8.2  

>gi|4758224 integral membrane protein 2A [Homo sapiens]
          Length = 263

 Score =  527 bits (1358), Expect = e-150
 Identities = 263/263 (100%), Positives = 263/263 (100%)

Query: 1   MVKIAFNTPTAVQKEEARQDVEALLSRTVRTQILTGKELRVATQEKEGSSGRCMLTLLGL 60
           MVKIAFNTPTAVQKEEARQDVEALLSRTVRTQILTGKELRVATQEKEGSSGRCMLTLLGL
Sbjct: 1   MVKIAFNTPTAVQKEEARQDVEALLSRTVRTQILTGKELRVATQEKEGSSGRCMLTLLGL 60

Query: 61  SFILAGLIVGGACIYKYFMPKSTIYRGEMCFFDSEDPANSLRGGEPNFLPVTEEADIRED 120
           SFILAGLIVGGACIYKYFMPKSTIYRGEMCFFDSEDPANSLRGGEPNFLPVTEEADIRED
Sbjct: 61  SFILAGLIVGGACIYKYFMPKSTIYRGEMCFFDSEDPANSLRGGEPNFLPVTEEADIRED 120

Query: 121 DNIAIIDVPVPSFSDSDPAAIIHDFEKGMTAYLDLLLGNCYLMPLNTSIVMPPKNLVELF 180
           DNIAIIDVPVPSFSDSDPAAIIHDFEKGMTAYLDLLLGNCYLMPLNTSIVMPPKNLVELF
Sbjct: 121 DNIAIIDVPVPSFSDSDPAAIIHDFEKGMTAYLDLLLGNCYLMPLNTSIVMPPKNLVELF 180

Query: 181 GKLASGRYLPQTYVVREDLVAVEEIRDVSNLGIFIYQLCNNRKSFRLRRRDLLLGFNKRA 240
           GKLASGRYLPQTYVVREDLVAVEEIRDVSNLGIFIYQLCNNRKSFRLRRRDLLLGFNKRA
Sbjct: 181 GKLASGRYLPQTYVVREDLVAVEEIRDVSNLGIFIYQLCNNRKSFRLRRRDLLLGFNKRA 240

Query: 241 IDKCWKIRHFPNEFIVETKICQE 263
           IDKCWKIRHFPNEFIVETKICQE
Sbjct: 241 IDKCWKIRHFPNEFIVETKICQE 263


>gi|11527402 integral membrane protein 2B [Homo sapiens]
          Length = 266

 Score =  201 bits (512), Expect = 4e-52
 Identities = 111/270 (41%), Positives = 163/270 (60%), Gaps = 14/270 (5%)

Query: 1   MVKIAFNTPTA---VQKEEARQDVEALL--SRTVRTQILTGKELRVATQEKEGSSGRCML 55
           MVK+ FN+  A    +K+E +   EAL+     V        ++    Q +      C  
Sbjct: 1   MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRRAW----CWC 56

Query: 56  TLLGLSFILAGLIVGGACIYKYF--MPKSTIYRGEMCFFDSEDPANSLRGGEPNFLPVTE 113
              GL+F+LAG+I+GGA +YKYF   P    Y G + +   +   N      P  L  T 
Sbjct: 57  MCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCG-IKYIKDDVILNEPSADAPAALYQTI 115

Query: 114 EADIR--EDDNIAIIDVPVPSFSDSDPAAIIHDFEKGMTAYLDLLLGNCYLMPLNTSIVM 171
           E +I+  E++ +  I VPVP F+DSDPA I+HDF K +TAYLDL L  CY++PLNTSIVM
Sbjct: 116 EENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVM 175

Query: 172 PPKNLVELFGKLASGRYLPQTYVVREDLVAVEEIRDVSNLGIFIYQLCNNRKSFRLRRRD 231
           PP+NL+EL   + +G YLPQ+Y++ E +V  + I ++ +LG FIY+LC+++++++L+RR+
Sbjct: 176 PPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRE 235

Query: 232 LLLGFNKRAIDKCWKIRHFPNEFIVETKIC 261
            + G  KR    C+ IRHF N+F VET IC
Sbjct: 236 TIKGIQKREASNCFAIRHFENKFAVETLIC 265


>gi|13569885 integral membrane protein 2C isoform 1 [Homo sapiens]
          Length = 267

 Score =  175 bits (443), Expect = 4e-44
 Identities = 104/271 (38%), Positives = 151/271 (55%), Gaps = 17/271 (6%)

Query: 1   MVKIAFNTPTA-VQKEEARQDVEALLSRTVRTQIL---TGKELRVATQEKEGSS--GRCM 54
           MVKI+F    A ++ ++A +   +  +    T+IL     +E     + K G S  G C 
Sbjct: 1   MVKISFQPAVAGIKGDKADKASASAPAPASATEILLTPAREEQPPQHRSKRGGSVGGVCY 60

Query: 55  LTLLGLSFILAGLIVGGACIYKYF----MPKSTIYRGEMCFFDSEDPANSLRGGEPNFLP 110
           L++ G+  +L GL+     IY+YF    + +   +R  + + DS      L       + 
Sbjct: 61  LSM-GMVVLLMGLVFASVYIYRYFFLAQLARDNFFRCGVLYEDS------LSSQVRTQME 113

Query: 111 VTEEADIREDDNIAIIDVPVPSFSDSDPAAIIHDFEKGMTAYLDLLLGNCYLMPLNTSIV 170
           + E+  I  D+N   I+VPVP F   DPA IIHDF++G+TAY D+ L  CY++ LNT+IV
Sbjct: 114 LEEDVKIYLDENYERINVPVPQFGGGDPADIIHDFQRGLTAYHDISLDKCYVIELNTTIV 173

Query: 171 MPPKNLVELFGKLASGRYLPQTYVVREDLVAVEEIRDVSNLGIFIYQLCNNRKSFRLRRR 230
           +PP+N  EL   +  G YLPQTY+++E++V  E + D   LG FIY LCN + ++RLRRR
Sbjct: 174 LPPRNFWELLMNVKRGTYLPQTYIIQEEMVVTEHVSDKEALGSFIYHLCNGKDTYRLRRR 233

Query: 231 DLLLGFNKRAIDKCWKIRHFPNEFIVETKIC 261
                 NKR    C  IRHF N F+VET IC
Sbjct: 234 ATRRRINKRGAKNCNAIRHFENTFVVETLIC 264


>gi|60302912 integral membrane protein 2C isoform 3 [Homo sapiens]
          Length = 220

 Score =  159 bits (403), Expect = 2e-39
 Identities = 75/153 (49%), Positives = 100/153 (65%)

Query: 109 LPVTEEADIREDDNIAIIDVPVPSFSDSDPAAIIHDFEKGMTAYLDLLLGNCYLMPLNTS 168
           + + E+  I  D+N   I+VPVP F   DPA IIHDF++G+TAY D+ L  CY++ LNT+
Sbjct: 65  MELEEDVKIYLDENYERINVPVPQFGGGDPADIIHDFQRGLTAYHDISLDKCYVIELNTT 124

Query: 169 IVMPPKNLVELFGKLASGRYLPQTYVVREDLVAVEEIRDVSNLGIFIYQLCNNRKSFRLR 228
           IV+PP+N  EL   +  G YLPQTY+++E++V  E + D   LG FIY LCN + ++RLR
Sbjct: 125 IVLPPRNFWELLMNVKRGTYLPQTYIIQEEMVVTEHVSDKEALGSFIYHLCNGKDTYRLR 184

Query: 229 RRDLLLGFNKRAIDKCWKIRHFPNEFIVETKIC 261
           RR      NKR    C  IRHF N F+VET IC
Sbjct: 185 RRATRRRINKRGAKNCNAIRHFENTFVVETLIC 217


>gi|60302914 integral membrane protein 2C isoform 2 [Homo sapiens]
          Length = 230

 Score =  119 bits (297), Expect = 4e-27
 Identities = 86/271 (31%), Positives = 125/271 (46%), Gaps = 54/271 (19%)

Query: 1   MVKIAFNTPTA-VQKEEARQDVEALLSRTVRTQIL---TGKELRVATQEKEGSS--GRCM 54
           MVKI+F    A ++ ++A +   +  +    T+IL     +E     + K G S  G C 
Sbjct: 1   MVKISFQPAVAGIKGDKADKASASAPAPASATEILLTPAREEQPPQHRSKRGGSVGGVCY 60

Query: 55  LTLLGLSFILAGLIVGGACIYKYF----MPKSTIYRGEMCFFDSEDPANSLRGGEPNFLP 110
           L++ G+  +L GL+     IY+YF    + +   +R  + + DS      L       + 
Sbjct: 61  LSM-GMVVLLMGLVFASVYIYRYFFLAQLARDNFFRCGVLYEDS------LSSQVRTQME 113

Query: 111 VTEEADIREDDNIAIIDVPVPSFSDSDPAAIIHDFEKGMTAYLDLLLGNCYLMPLNTSIV 170
           + E+  I  D+N   I+VPVP F   DPA IIHDF++                       
Sbjct: 114 LEEDVKIYLDENYERINVPVPQFGGGDPADIIHDFQR----------------------- 150

Query: 171 MPPKNLVELFGKLASGRYLPQTYVVREDLVAVEEIRDVSNLGIFIYQLCNNRKSFRLRRR 230
                          G YLPQTY+++E++V  E + D   LG FIY LCN + ++RLRRR
Sbjct: 151 --------------RGTYLPQTYIIQEEMVVTEHVSDKEALGSFIYHLCNGKDTYRLRRR 196

Query: 231 DLLLGFNKRAIDKCWKIRHFPNEFIVETKIC 261
                 NKR    C  IRHF N F+VET IC
Sbjct: 197 ATRRRINKRGAKNCNAIRHFENTFVVETLIC 227


>gi|197209974 coiled-coil and C2 domain containing 2A isoform a [Homo
            sapiens]
          Length = 1620

 Score = 30.4 bits (67), Expect = 1.6
 Identities = 11/42 (26%), Positives = 26/42 (61%)

Query: 189  LPQTYVVREDLVAVEEIRDVSNLGIFIYQLCNNRKSFRLRRR 230
            + + Y +  D++  EE+ ++S LG+ +++L   ++  R RR+
Sbjct: 985  IAKQYFLLADMIVEEEVPNISILGLSLFKLAEQKRPLRPRRK 1026


>gi|197209817 coiled-coil and C2 domain containing 2A isoform b
           [Homo sapiens]
          Length = 1512

 Score = 30.4 bits (67), Expect = 1.6
 Identities = 11/42 (26%), Positives = 26/42 (61%)

Query: 189 LPQTYVVREDLVAVEEIRDVSNLGIFIYQLCNNRKSFRLRRR 230
           + + Y +  D++  EE+ ++S LG+ +++L   ++  R RR+
Sbjct: 936 IAKQYFLLADMIVEEEVPNISILGLSLFKLAEQKRPLRPRRK 977


>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
           2 [Homo sapiens]
          Length = 1704

 Score = 29.3 bits (64), Expect = 3.7
 Identities = 15/37 (40%), Positives = 22/37 (59%)

Query: 12  VQKEEARQDVEALLSRTVRTQILTGKELRVATQEKEG 48
           V+KEE R D  ++L   +++Q LT +   V T EK G
Sbjct: 556 VEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCG 592


>gi|40254988 LSM domain containing 1 [Homo sapiens]
          Length = 173

 Score = 28.1 bits (61), Expect = 8.2
 Identities = 12/25 (48%), Positives = 19/25 (76%)

Query: 15  EEARQDVEALLSRTVRTQILTGKEL 39
           E ARQ +EALL++T+R ++  G+ L
Sbjct: 87  ERARQQLEALLNKTMRIRMTDGRTL 111


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.140    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,814,620
Number of Sequences: 37866
Number of extensions: 441688
Number of successful extensions: 853
Number of sequences better than 10.0: 9
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 840
Number of HSP's gapped (non-prelim): 10
length of query: 263
length of database: 18,247,518
effective HSP length: 100
effective length of query: 163
effective length of database: 14,460,918
effective search space: 2357129634
effective search space used: 2357129634
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.