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Search of human proteins with 45827809
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45827809 mitogen-activated protein kinase kinase kinase 6
[Homo sapiens]
(1288 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Ho... 2597 0.0
gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Hom... 1103 0.0
gi|121583542 mitogen-activated protein kinase kinase kinase 15 [... 632 0.0
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 186 1e-46
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 186 1e-46
gi|42794767 mitogen-activated protein kinase kinase kinase 3 iso... 167 6e-41
gi|42794765 mitogen-activated protein kinase kinase kinase 3 iso... 167 6e-41
gi|55956904 mitogen-activated protein kinase kinase kinase 4 iso... 160 6e-39
gi|55956902 mitogen-activated protein kinase kinase kinase 4 iso... 160 6e-39
gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Ho... 160 7e-39
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H... 155 3e-37
gi|29826329 p21-activated kinase 7 [Homo sapiens] 141 5e-33
gi|24308191 p21-activated kinase 7 [Homo sapiens] 141 5e-33
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 141 5e-33
gi|191252782 p21-activated kinase 6 [Homo sapiens] 140 1e-32
gi|191252780 p21-activated kinase 6 [Homo sapiens] 140 1e-32
gi|9910476 p21-activated kinase 6 [Homo sapiens] 140 1e-32
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 138 4e-32
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 137 5e-32
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 137 7e-32
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 137 7e-32
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 137 7e-32
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 137 7e-32
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 137 7e-32
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 137 7e-32
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 137 9e-32
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 136 1e-31
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 136 1e-31
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 136 1e-31
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 135 2e-31
>gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Homo
sapiens]
Length = 1288
Score = 2597 bits (6730), Expect = 0.0
Identities = 1288/1288 (100%), Positives = 1288/1288 (100%)
Query: 1 MAGPCPRSGAERAGSCWQDPLAVALSRGRQLAAPPGRGCARSRPLSVVYVLTREPQPGLE 60
MAGPCPRSGAERAGSCWQDPLAVALSRGRQLAAPPGRGCARSRPLSVVYVLTREPQPGLE
Sbjct: 1 MAGPCPRSGAERAGSCWQDPLAVALSRGRQLAAPPGRGCARSRPLSVVYVLTREPQPGLE 60
Query: 61 PREGTEAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDAFYNADVVVLEV 120
PREGTEAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDAFYNADVVVLEV
Sbjct: 61 PREGTEAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDAFYNADVVVLEV 120
Query: 121 SSSLVQPSLFYHLGVRESFSMTNNVLLCSQADLPDLQALREDVFQKNSDCVGSYTLIPYV 180
SSSLVQPSLFYHLGVRESFSMTNNVLLCSQADLPDLQALREDVFQKNSDCVGSYTLIPYV
Sbjct: 121 SSSLVQPSLFYHLGVRESFSMTNNVLLCSQADLPDLQALREDVFQKNSDCVGSYTLIPYV 180
Query: 181 VTATGRVLCGDAGLLRGLADGLVQAGVGTEALLTPLVGRLARLLEATPTDSCGYFRETIR 240
VTATGRVLCGDAGLLRGLADGLVQAGVGTEALLTPLVGRLARLLEATPTDSCGYFRETIR
Sbjct: 181 VTATGRVLCGDAGLLRGLADGLVQAGVGTEALLTPLVGRLARLLEATPTDSCGYFRETIR 240
Query: 241 RDIRQARERFSGPQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETL 300
RDIRQARERFSGPQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETL
Sbjct: 241 RDIRQARERFSGPQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETL 300
Query: 301 QALPTCDVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRIY 360
QALPTCDVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRIY
Sbjct: 301 QALPTCDVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRIY 360
Query: 361 KDMFFSSGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSKELRLIGM 420
KDMFFSSGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSKELRLIGM
Sbjct: 361 KDMFFSSGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSKELRLIGM 420
Query: 421 KLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMET 480
KLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMET
Sbjct: 421 KLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMET 480
Query: 481 FLLYQHFRPTPEPPGGPPRRAHFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAK 540
FLLYQHFRPTPEPPGGPPRRAHFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAK
Sbjct: 481 FLLYQHFRPTPEPPGGPPRRAHFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAK 540
Query: 541 LEVRGTDPVSTVTLSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQ 600
LEVRGTDPVSTVTLSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQ
Sbjct: 541 LEVRGTDPVSTVTLSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQ 600
Query: 601 LCFPSVGHCQWFCGLIQAWVTNPDSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYG 660
LCFPSVGHCQWFCGLIQAWVTNPDSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYG
Sbjct: 601 LCFPSVGHCQWFCGLIQAWVTNPDSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYG 660
Query: 661 VVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKI 720
VVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKI
Sbjct: 661 VVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKI 720
Query: 721 FMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLIN 780
FMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLIN
Sbjct: 721 FMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLIN 780
Query: 781 TFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVI 840
TFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVI
Sbjct: 781 TFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVI 840
Query: 841 EMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTL 900
EMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTL
Sbjct: 841 EMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTL 900
Query: 901 LGDPFLQPGKRSRSPSSPRHAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPSPPK 960
LGDPFLQPGKRSRSPSSPRHAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPSPPK
Sbjct: 901 LGDPFLQPGKRSRSPSSPRHAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPSPPK 960
Query: 961 RCLSYGGTSQLRVPEEPAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQELPALAENLH 1020
RCLSYGGTSQLRVPEEPAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQELPALAENLH
Sbjct: 961 RCLSYGGTSQLRVPEEPAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQELPALAENLH 1020
Query: 1021 QEQKQEQGARLGRNHVEELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPL 1080
QEQKQEQGARLGRNHVEELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPL
Sbjct: 1021 QEQKQEQGARLGRNHVEELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPL 1080
Query: 1081 FAFPDAVKQILRKRQIRPHWMFVLDSLLSRAVRAALGVLGPEVEKEAVSPRSEELSNEGD 1140
FAFPDAVKQILRKRQIRPHWMFVLDSLLSRAVRAALGVLGPEVEKEAVSPRSEELSNEGD
Sbjct: 1081 FAFPDAVKQILRKRQIRPHWMFVLDSLLSRAVRAALGVLGPEVEKEAVSPRSEELSNEGD 1140
Query: 1141 SQQSPGQQSPLPVEPEQGPAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLNE 1200
SQQSPGQQSPLPVEPEQGPAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLNE
Sbjct: 1141 SQQSPGQQSPLPVEPEQGPAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLNE 1200
Query: 1201 EARTYVLAPEPPTALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLTYATRDDLIYT 1260
EARTYVLAPEPPTALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLTYATRDDLIYT
Sbjct: 1201 EARTYVLAPEPPTALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLTYATRDDLIYT 1260
Query: 1261 RIRGGMVCRIWRAILAQRAGSTPVTSGP 1288
RIRGGMVCRIWRAILAQRAGSTPVTSGP
Sbjct: 1261 RIRGGMVCRIWRAILAQRAGSTPVTSGP 1288
>gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Homo
sapiens]
Length = 1374
Score = 1103 bits (2853), Expect = 0.0
Identities = 623/1344 (46%), Positives = 834/1344 (62%), Gaps = 96/1344 (7%)
Query: 14 GSCWQDPLAVALSRGRQLA-----APPGRGCA---RSRPLSVVYVLTREPQPGLEPREGT 65
GS W A A G A A GRG + SR +V YV+ Q L
Sbjct: 52 GSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQL-----V 106
Query: 66 EAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDAFYNADVVVLEVSSSLV 125
AE L+ LREAC V L +L FG L+ G+T LD FYNAD+ V+E+S +
Sbjct: 107 VAESEALQSLREACETVGAT-----LETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFR 161
Query: 126 QPSLFYHLGVRESFSMTNNVLLCSQADLPDLQALREDVFQKNSDCVGSYTLIPYVVTATG 185
QPSLFYHLGVRESFSM NN++L + LQ+L+E + QKN+ C G+YT +PY++T
Sbjct: 162 QPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHN 221
Query: 186 RVLCGDAGLLRGLADGLVQAGVGTEALL----TPLVGRLARLLEATPTDSCGYFRETIRR 241
+V C D+ ++GL + L+Q E LL PLV R +LL+ S YFRE+I
Sbjct: 222 KVYCCDSSFMKGLTE-LMQPNF--ELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILN 278
Query: 242 DIRQARERFSGPQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETLQ 301
DIR+AR ++G +L ELAR+++R+D++E+L+ DI++NLLLSYRD+QDY +I++LVETL+
Sbjct: 279 DIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLE 338
Query: 302 ALPTCDVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRIYK 361
LPT D+A H+V FHY FALNRRN PGDRAKAL +++P+VQ EG VA D+YC+ GRIYK
Sbjct: 339 KLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYK 398
Query: 362 DMFFSSGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSKELRLIGMK 421
DMF S F D R+ W++KAF+ EP+L SGIN AVLL+AAG FE S ELR +G+K
Sbjct: 399 DMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVK 458
Query: 422 LGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMETF 481
L LL +KG +EK+Q YW+VGF+LGA +LAND +V+ A+E+L+KL P WYL S++ET
Sbjct: 459 LSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETI 518
Query: 482 LLYQHF-RPTPEPPGGPPRRAHFWLHFLLQSCQPFKTACAQGDQCLVLVLEMNKVLLPAK 540
L+Y+HF + T E P FW+ FL+++ + T + VL+LE K+ P+
Sbjct: 519 LIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVV----RFPVLILEPTKIYQPSY 574
Query: 541 LEVRGTDPVSTVTLSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQ 600
L + T+++ + P+ + W F +S+ GVS SK +ERCCFLY L + D Q
Sbjct: 575 LSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQ 634
Query: 601 LCFPSVGHCQWFCGLIQAWVTNPDSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYG 660
+ F + HC+ F ++ + EE + ++LE+DYEY E G+R+VLGKGTYG
Sbjct: 635 IYFCTELHCKKFFEMVNT--ITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYG 692
Query: 661 VVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKI 720
+VYAGRD +VRIAIKEIPERDSR+SQPLHEEIALH+ L+HKNIV+YLGS S+ G++KI
Sbjct: 693 IVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKI 752
Query: 721 FMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLIN 780
FME+VPGGSLS+LLRS WGPLKDNE TI FYT+QIL+GL YLHDN IVHRDIKGDNVLIN
Sbjct: 753 FMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLIN 812
Query: 781 TFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVI 840
T+SG+LKISDFGTSKRLAGI PCTETFTGTLQYMAPEIID+GPRGYGKAADIWSLGCT+I
Sbjct: 813 TYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTII 872
Query: 841 EMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTL 900
EMATG+PPF+ELG PQAAMF+VGM+KVHP +P S+SAEA+AF+L+ FEPDP RA A L
Sbjct: 873 EMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDL 932
Query: 901 LGDPFL---------QPGKRSRSPSSPRH-----APRP---SDAPSASPTPSANSTTQSQ 943
L D FL QP + S S + P P D S+S S + T+ +
Sbjct: 933 LVDEFLKVSSKKKKTQPKLSALSAGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPDTELK 992
Query: 944 TFPCPQAPSQHPPSPPKRCLSYGGTSQLRVPEEPAAEE--PASPEE-SSGLSLLHQESKR 1000
P + S +R + T L +P+E + P SPEE SG +L ++S+R
Sbjct: 993 VDPF--SFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSER 1050
Query: 1001 RAMLAAVLEQELPALAENLHQEQKQ-EQGARLGRNHVEELLRCLGAHIHTPNRRQLAQEL 1059
RA L +L ++ + NL + Q + +L H+ L+ L + + +R+ +A L
Sbjct: 1051 RATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIATTL 1110
Query: 1060 RALQGRLRAQGLGPALLHRPLFAFPDAVKQILRKRQIRPHWMFVLDSLLSRAVRAALGVL 1119
L+ L G + + LF F DAV ++LR I+PHWMF LDS++ +AV+ A+ +L
Sbjct: 1111 SKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITIL 1170
Query: 1120 GPEVE------KEAVSPRSEELSNEGDSQQSPGQQ----------------------SPL 1151
PE+ E+ + E+L E D ++ P Q S +
Sbjct: 1171 VPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSSTV 1230
Query: 1152 PVEPEQGPAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLNEEARTYVLAPEP 1211
+ + L VQL ++ ET+RL E L KE+E QAL+ RA++ ++E + L +P
Sbjct: 1231 SHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQP 1290
Query: 1212 -------------PTALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLTYATRDDLI 1258
+ D L WL+ D TI L +TL +L Y TRDDL
Sbjct: 1291 IEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDDLK 1350
Query: 1259 YTRIRGGMVCRIWRAILAQRAGST 1282
R+RGGM+C +W+AI+ R T
Sbjct: 1351 CLRLRGGMLCTLWKAIIDFRNKQT 1374
>gi|121583542 mitogen-activated protein kinase kinase kinase 15 [Homo
sapiens]
Length = 788
Score = 632 bits (1629), Expect = 0.0
Identities = 354/748 (47%), Positives = 467/748 (62%), Gaps = 55/748 (7%)
Query: 564 IPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQLCFPSVGHCQWFCGLIQAWVTNP 623
+ SSW + S SK DERCCFLY + D Q+ F + C F L++ +TN
Sbjct: 51 LQSSWDY--------SLSKFDERCCFLYVHDNSDDFQIYFSTEEQCSRFFSLVKEMITNT 102
Query: 624 DSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERD 683
+ E E G+ LE++Y++ GER+VLGKGTYG+VYAGRD +VRIAIKEIPERD
Sbjct: 103 AGSTVELEGETDGDTLEYEYDHDANGERVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERD 162
Query: 684 SRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKD 743
SR+SQPLHEEIALH+ L+H+NIV+YLGS S+ GY+KIFME+VPGGSLS+LLRS WGP+K
Sbjct: 163 SRYSQPLHEEIALHKYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMK- 221
Query: 744 NESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPC 803
E TI FYT+QIL+GL YLH+N IVHRDIKGDNVL+NT+SG++KISDFGTSKRLAG+ PC
Sbjct: 222 -EPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPC 280
Query: 804 TETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVG 863
TETFTGTLQYMAPEIIDQGPRGYG ADIWSLGCT+IEMAT +PPFHELG PQAAMF+VG
Sbjct: 281 TETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVG 340
Query: 864 MYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFLQ---PGKRSRSPSSPRH 920
M+K+HP +P +LSAEA+AF+L FEPDP RA+ LL + FL+ GK++R P
Sbjct: 341 MFKIHPEIPEALSAEARAFILSCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSE 400
Query: 921 APRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPS-------PPKRCLSYGGTSQLRV 973
PR A PT T S S P P+ L + L V
Sbjct: 401 GPR--GVVLALPTQGEPMATSSSEHGSVSPDSDAQPDALFERTRAPRHHLGH----LLSV 454
Query: 974 PEEPAAEE----PASPEE-SSGLSLLHQESKRRAMLAAVLEQELPALAENLHQ-EQKQEQ 1027
P+E +A E +SPE+ GL LL ++S+RRA+L +L +E +A NL + + +
Sbjct: 455 PDESSALEDRGLASSPEDRDQGLFLLRKDSERRAILYKILWEEQNQVASNLQECVAQSSE 514
Query: 1028 GARLGRNHVEELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPLFAFPDAV 1087
L H+++++ L I +P R +A + L+ L + +H LF F DAV
Sbjct: 515 ELHLSVGHIKQIIGILRDFIRSPEHRVMATTISKLKVDLDFDSSSISQIHLVLFGFQDAV 574
Query: 1088 KQILRKRQIRPHWMFVLDSLLSRAVRAALGVLGPEV--------EKEAVSPRSEELSNEG 1139
+ILR IRPHWMF +D+++ RAV+AA+ +L PE+ E E V +E
Sbjct: 575 NKILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELRAHFEPTCETEGVDKDMDEAEEGY 634
Query: 1140 DSQQSPGQQSPLPVEPEQGPAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLN 1199
PGQ++ +P Q L +QL LR ET+RL E L KEREYQ L+++ L++
Sbjct: 635 PPATGPGQEA----QPHQ--QHLSLQLGELRQETNRLLEHLVEKEREYQNLLRQTLEQKT 688
Query: 1200 EEARTYVLA---------PEPPTALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLT 1250
+E L P P TD+ L+ WL+ D+ TI+ ++ +TL +L
Sbjct: 689 QELYHLQLKLKSNCITENPAGPYGQRTDKELIDWLRLQGADAKTIEKIVEEGYTLSDILN 748
Query: 1251 YATRDDLIYTRIRGGMVCRIWRAILAQR 1278
T++DL Y R+RGG++CR+W A+ R
Sbjct: 749 EITKEDLRYLRLRGGLLCRLWSAVSQYR 776
>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
sapiens]
Length = 1328
Score = 186 bits (472), Expect = 1e-46
Identities = 113/268 (42%), Positives = 162/268 (60%), Gaps = 21/268 (7%)
Query: 653 VLGKGTYGVVYAGRDRHTRVRIAIKEIPERDS------RFSQPLHEEIALHRRLRHKNIV 706
+LGKG YG VY G ++ IA+K++ S + + L EE+ L + L+H NIV
Sbjct: 1066 ILGKGAYGTVYCGLTSQGQL-IAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 1124
Query: 707 RYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNH 766
YLG+ Q + IFME VPGGS+SS++ +GPL E YT+QILQG+ YLH+N
Sbjct: 1125 AYLGTCLQENTVSIFMEFVPGGSISSIINR-FGPLP--EMVFCKYTKQILQGVAYLHENC 1181
Query: 767 IVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGI------TPCTETFTGTLQYMAPEIID 820
+VHRDIKG+NV++ +G++K+ DFG ++RLA + ++ GT +MAPE+I+
Sbjct: 1182 VVHRDIKGNNVMLMP-TGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVIN 1240
Query: 821 QGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYK-VHPPMPSSLSAEA 879
+ GYG+ +DIWS+GCTV EMATG+PP + AAMF +G ++ + PP+P S A
Sbjct: 1241 ES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHRGLMPPLPDHFSENA 1297
Query: 880 QAFLLRTFEPDPRLRASAQTLLGDPFLQ 907
F+ D R SA LL FL+
Sbjct: 1298 ADFVRMCLTRDQHERPSALQLLKHSFLE 1325
>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
Length = 510
Score = 186 bits (472), Expect = 1e-46
Identities = 113/268 (42%), Positives = 162/268 (60%), Gaps = 21/268 (7%)
Query: 653 VLGKGTYGVVYAGRDRHTRVRIAIKEIPERDS------RFSQPLHEEIALHRRLRHKNIV 706
+LGKG YG VY G ++ IA+K++ S + + L EE+ L + L+H NIV
Sbjct: 248 ILGKGAYGTVYCGLTSQGQL-IAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 306
Query: 707 RYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNH 766
YLG+ Q + IFME VPGGS+SS++ +GPL E YT+QILQG+ YLH+N
Sbjct: 307 AYLGTCLQENTVSIFMEFVPGGSISSIINR-FGPLP--EMVFCKYTKQILQGVAYLHENC 363
Query: 767 IVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGI------TPCTETFTGTLQYMAPEIID 820
+VHRDIKG+NV++ +G++K+ DFG ++RLA + ++ GT +MAPE+I+
Sbjct: 364 VVHRDIKGNNVMLMP-TGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVIN 422
Query: 821 QGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYK-VHPPMPSSLSAEA 879
+ GYG+ +DIWS+GCTV EMATG+PP + AAMF +G ++ + PP+P S A
Sbjct: 423 ES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHRGLMPPLPDHFSENA 479
Query: 880 QAFLLRTFEPDPRLRASAQTLLGDPFLQ 907
F+ D R SA LL FL+
Sbjct: 480 ADFVRMCLTRDQHERPSALQLLKHSFLE 507
>gi|42794767 mitogen-activated protein kinase kinase kinase 3
isoform 1 [Homo sapiens]
Length = 657
Score = 167 bits (423), Expect = 6e-41
Identities = 112/266 (42%), Positives = 153/266 (57%), Gaps = 20/266 (7%)
Query: 653 VLGKGTYGVVYAGRDRHTRVRIAIKEI------PERDSRFSQPLHEEIALHRRLRHKNIV 706
+LG+G +G VY D T +A K++ PE S L EI L + L+H+ IV
Sbjct: 398 LLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSA-LECEIQLLKNLQHERIV 456
Query: 707 RYLGSASQGGY--LKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHD 764
+Y G L IFME +PGGS+ L++ +G L ES YTRQIL+G+ YLH
Sbjct: 457 QYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKA-YGAL--TESVTRKYTRQILEGMSYLHS 513
Query: 765 NHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPC---TETFTGTLQYMAPEIIDQ 821
N IVHRDIKG N+L ++ +G +K+ DFG SKRL I + TGT +M+PE+I
Sbjct: 514 NMIVHRDIKGANILRDS-AGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI-- 570
Query: 822 GPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQA 881
GYG+ AD+WSLGCTV+EM T +PP+ E AA+F++ +P +PS +S +
Sbjct: 571 SGEGYGRKADVWSLGCTVVEMLTEKPPWAEY-EAMAAIFKIATQPTNPQLPSHISEHGRD 629
Query: 882 FLLRTFEPDPRLRASAQTLLGDPFLQ 907
FL R F + R R SA+ LL F Q
Sbjct: 630 FLRRIF-VEARQRPSAEELLTHHFAQ 654
>gi|42794765 mitogen-activated protein kinase kinase kinase 3
isoform 2 [Homo sapiens]
Length = 626
Score = 167 bits (423), Expect = 6e-41
Identities = 112/266 (42%), Positives = 153/266 (57%), Gaps = 20/266 (7%)
Query: 653 VLGKGTYGVVYAGRDRHTRVRIAIKEI------PERDSRFSQPLHEEIALHRRLRHKNIV 706
+LG+G +G VY D T +A K++ PE S L EI L + L+H+ IV
Sbjct: 367 LLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSA-LECEIQLLKNLQHERIV 425
Query: 707 RYLGSASQGGY--LKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHD 764
+Y G L IFME +PGGS+ L++ +G L ES YTRQIL+G+ YLH
Sbjct: 426 QYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKA-YGAL--TESVTRKYTRQILEGMSYLHS 482
Query: 765 NHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPC---TETFTGTLQYMAPEIIDQ 821
N IVHRDIKG N+L ++ +G +K+ DFG SKRL I + TGT +M+PE+I
Sbjct: 483 NMIVHRDIKGANILRDS-AGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI-- 539
Query: 822 GPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQA 881
GYG+ AD+WSLGCTV+EM T +PP+ E AA+F++ +P +PS +S +
Sbjct: 540 SGEGYGRKADVWSLGCTVVEMLTEKPPWAEY-EAMAAIFKIATQPTNPQLPSHISEHGRD 598
Query: 882 FLLRTFEPDPRLRASAQTLLGDPFLQ 907
FL R F + R R SA+ LL F Q
Sbjct: 599 FLRRIF-VEARQRPSAEELLTHHFAQ 623
>gi|55956904 mitogen-activated protein kinase kinase kinase 4 isoform
a [Homo sapiens]
Length = 1608
Score = 160 bits (406), Expect = 6e-39
Identities = 104/261 (39%), Positives = 144/261 (55%), Gaps = 14/261 (5%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEI--PERDSRFSQPLHEEIALHRRLRHKNIVRYLGS 711
+G+G YG VY T +A+KEI D + + +E+ + ++H N+VRY G
Sbjct: 1349 IGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGV 1408
Query: 712 ASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRD 771
+ IFME G+L + R L E I Y++QI + LH++ IVHRD
Sbjct: 1409 ELHREEMYIFMEYCDEGTLEEVSR-----LGLQEHVIRLYSKQITIAINVLHEHGIVHRD 1463
Query: 772 IKGDNVLINTFSGLLKISDFGTSKRL---AGITPCTETFT-GTLQYMAPEIIDQGP-RGY 826
IKG N+ + T SGL+K+ DFG S +L A P T GT YMAPE+I + G+
Sbjct: 1464 IKGANIFL-TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGH 1522
Query: 827 GKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRT 886
G+AADIWSLGC VIEM TG+ P+HE M++VGM PP+P LS E + FL
Sbjct: 1523 GRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERLSPEGKDFLSHC 1581
Query: 887 FEPDPRLRASAQTLLGDPFLQ 907
E DP++R +A LL F++
Sbjct: 1582 LESDPKMRWTASQLLDHSFVK 1602
>gi|55956902 mitogen-activated protein kinase kinase kinase 4 isoform
b [Homo sapiens]
Length = 1558
Score = 160 bits (406), Expect = 6e-39
Identities = 104/261 (39%), Positives = 144/261 (55%), Gaps = 14/261 (5%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEI--PERDSRFSQPLHEEIALHRRLRHKNIVRYLGS 711
+G+G YG VY T +A+KEI D + + +E+ + ++H N+VRY G
Sbjct: 1299 IGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGV 1358
Query: 712 ASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRD 771
+ IFME G+L + R L E I Y++QI + LH++ IVHRD
Sbjct: 1359 ELHREEMYIFMEYCDEGTLEEVSR-----LGLQEHVIRLYSKQITIAINVLHEHGIVHRD 1413
Query: 772 IKGDNVLINTFSGLLKISDFGTSKRL---AGITPCTETFT-GTLQYMAPEIIDQGP-RGY 826
IKG N+ + T SGL+K+ DFG S +L A P T GT YMAPE+I + G+
Sbjct: 1414 IKGANIFL-TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGH 1472
Query: 827 GKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRT 886
G+AADIWSLGC VIEM TG+ P+HE M++VGM PP+P LS E + FL
Sbjct: 1473 GRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERLSPEGKDFLSHC 1531
Query: 887 FEPDPRLRASAQTLLGDPFLQ 907
E DP++R +A LL F++
Sbjct: 1532 LESDPKMRWTASQLLDHSFVK 1552
>gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Homo
sapiens]
Length = 619
Score = 160 bits (405), Expect = 7e-39
Identities = 109/265 (41%), Positives = 155/265 (58%), Gaps = 20/265 (7%)
Query: 653 VLGKGTYGVVYAGRDRHTRVRIAIKEI------PERDSRFSQPLHEEIALHRRLRHKNIV 706
+LG+G +G VY D T +A+K++ PE S+ L EI L + L H+ IV
Sbjct: 361 LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPET-SKEVNALECEIQLLKNLLHERIV 419
Query: 707 RYLGSAS--QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHD 764
+Y G Q L IFME +PGGS+ L++ +G L +N + YTRQIL+G+ YLH
Sbjct: 420 QYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKA-YGALTENVTRK--YTRQILEGVHYLHS 476
Query: 765 NHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGIT---PCTETFTGTLQYMAPEIIDQ 821
N IVHRDIKG N+L ++ +G +K+ DFG SKRL I ++ TGT +M+PE+I
Sbjct: 477 NMIVHRDIKGANILRDS-TGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVI-- 533
Query: 822 GPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQA 881
GYG+ ADIWS+ CTV+EM T +PP+ E AA+F++ +P +P +S +
Sbjct: 534 SGEGYGRKADIWSVACTVVEMLTEKPPWAEF-EAMAAIFKIATQPTNPKLPPHVSDYTRD 592
Query: 882 FLLRTFEPDPRLRASAQTLLGDPFL 906
FL R F + +LR SA LL F+
Sbjct: 593 FLKRIF-VEAKLRPSADELLRHMFV 616
>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
sapiens]
Length = 1512
Score = 155 bits (391), Expect = 3e-37
Identities = 96/273 (35%), Positives = 151/273 (55%), Gaps = 17/273 (6%)
Query: 644 EYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIP------ERDSRFSQPLHEEIALH 697
E TE + +G G + Y +D T +A+K++ + L EEI +
Sbjct: 1239 EDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMM 1298
Query: 698 RRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQ 757
L H NI+R LG+ + +F+E + GGS++ LL S +G K ES + YT Q+L+
Sbjct: 1299 SHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLL-SKYGAFK--ESVVINYTEQLLR 1355
Query: 758 GLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLA----GITPCTETFTGTLQY 813
GL YLH+N I+HRD+KG N+LI++ L+I+DFG + RLA G GT+ +
Sbjct: 1356 GLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAF 1415
Query: 814 MAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFH--ELGSPQAAMFQVGMYKVHPPM 871
MAPE++ +G + YG++ D+WS+GC +IEMA +PP++ + + A +F++ P +
Sbjct: 1416 MAPEVL-RGQQ-YGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSI 1473
Query: 872 PSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDP 904
PS LS + LR E P+ R ++ LL P
Sbjct: 1474 PSHLSPGLRDVALRCLELQPQDRPPSRELLKHP 1506
>gi|29826329 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 141 bits (355), Expect = 5e-33
Identities = 87/260 (33%), Positives = 139/260 (53%), Gaps = 19/260 (7%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSAS 713
+G+G+ G+V ++HT ++A+K++ R + + L E+ + R H N+V S
Sbjct: 455 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYL 514
Query: 714 QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIK 773
G L + ME + GG+L+ ++ + NE I+ +L+ L YLH+ ++HRDIK
Sbjct: 515 VGDELWVVMEFLEGGALTDIVTHT----RMNEEQIATVCLSVLRALSYLHNQGVIHRDIK 570
Query: 774 GDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIW 833
D++L+ T G +K+SDFG +++ P ++ GT +MAPE+I + P YG DIW
Sbjct: 571 SDSILL-TSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLP--YGTEVDIW 627
Query: 834 SLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMP------SSLSAEAQAFLLRTF 887
SLG VIEM G PP+ QA M ++ +P +S+ + FL
Sbjct: 628 SLGIMVIEMIDGEPPYFNEPPLQA------MRRIRDSLPPRVKDLHKVSSVLRGFLDLML 681
Query: 888 EPDPRLRASAQTLLGDPFLQ 907
+P RA+AQ LLG PFL+
Sbjct: 682 VREPSQRATAQELLGHPFLK 701
>gi|24308191 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 141 bits (355), Expect = 5e-33
Identities = 87/260 (33%), Positives = 139/260 (53%), Gaps = 19/260 (7%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSAS 713
+G+G+ G+V ++HT ++A+K++ R + + L E+ + R H N+V S
Sbjct: 455 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYL 514
Query: 714 QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIK 773
G L + ME + GG+L+ ++ + NE I+ +L+ L YLH+ ++HRDIK
Sbjct: 515 VGDELWVVMEFLEGGALTDIVTHT----RMNEEQIATVCLSVLRALSYLHNQGVIHRDIK 570
Query: 774 GDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIW 833
D++L+ T G +K+SDFG +++ P ++ GT +MAPE+I + P YG DIW
Sbjct: 571 SDSILL-TSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLP--YGTEVDIW 627
Query: 834 SLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMP------SSLSAEAQAFLLRTF 887
SLG VIEM G PP+ QA M ++ +P +S+ + FL
Sbjct: 628 SLGIMVIEMIDGEPPYFNEPPLQA------MRRIRDSLPPRVKDLHKVSSVLRGFLDLML 681
Query: 888 EPDPRLRASAQTLLGDPFLQ 907
+P RA+AQ LLG PFL+
Sbjct: 682 VREPSQRATAQELLGHPFLK 701
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 141 bits (355), Expect = 5e-33
Identities = 98/255 (38%), Positives = 138/255 (54%), Gaps = 12/255 (4%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFS-QPLHEEIALHRRLRHKNIVRYLGSA 712
+GKG++G VY G D HT+ +AIK I ++ + + +EI + + I RY GS
Sbjct: 26 IGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSY 85
Query: 713 SQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDI 772
+ L I ME + GGS LL+ GPL+ E+ I+ R+IL+GL YLH +HRDI
Sbjct: 86 LKSTKLWIIMEYLGGGSALDLLKP--GPLE--ETYIATILREILKGLDYLHSERKIHRDI 141
Query: 773 KGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADI 832
K NVL++ G +K++DFG + +L TF GT +MAPE+I Q Y ADI
Sbjct: 142 KAANVLLSE-QGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS--AYDFKADI 198
Query: 833 WSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPP-MPSSLSAEAQAFLLRTFEPDP 891
WSLG T IE+A G PP +L P +F + K PP + S + F+ DP
Sbjct: 199 WSLGITAIELAKGEPPNSDL-HPMRVLFLIP--KNSPPTLEGQHSKPFKEFVEACLNKDP 255
Query: 892 RLRASAQTLLGDPFL 906
R R +A+ LL F+
Sbjct: 256 RFRPTAKELLKHKFI 270
>gi|191252782 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 140 bits (352), Expect = 1e-32
Identities = 90/257 (35%), Positives = 139/257 (54%), Gaps = 15/257 (5%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSAS 713
+G+G+ G+V R++H+ ++A+K + R + + L E+ + R +H N+V S
Sbjct: 413 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYL 472
Query: 714 QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIK 773
G L + ME + GG+L+ ++ V + NE I+ +LQ L YLH ++HRDIK
Sbjct: 473 VGEELWVLMEFLQGGALTDIVSQV----RLNEEQIATVCEAVLQALAYLHAQGVIHRDIK 528
Query: 774 GDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIW 833
D++L+ T G +K+SDFG +++ P ++ GT +MAPE+I + Y DIW
Sbjct: 529 SDSILL-TLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL--YATEVDIW 585
Query: 834 SLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPP----MPSSLSAEAQAFLLRTFEP 889
SLG VIEM G PP+ SP AM ++ + PP +S + FL R
Sbjct: 586 SLGIMVIEMVDGEPPYFS-DSPVQAMKRL---RDSPPPKLKNSHKVSPVLRDFLERMLVR 641
Query: 890 DPRLRASAQTLLGDPFL 906
DP+ RA+AQ LL PFL
Sbjct: 642 DPQERATAQELLDHPFL 658
>gi|191252780 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 140 bits (352), Expect = 1e-32
Identities = 90/257 (35%), Positives = 139/257 (54%), Gaps = 15/257 (5%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSAS 713
+G+G+ G+V R++H+ ++A+K + R + + L E+ + R +H N+V S
Sbjct: 413 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYL 472
Query: 714 QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIK 773
G L + ME + GG+L+ ++ V + NE I+ +LQ L YLH ++HRDIK
Sbjct: 473 VGEELWVLMEFLQGGALTDIVSQV----RLNEEQIATVCEAVLQALAYLHAQGVIHRDIK 528
Query: 774 GDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIW 833
D++L+ T G +K+SDFG +++ P ++ GT +MAPE+I + Y DIW
Sbjct: 529 SDSILL-TLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL--YATEVDIW 585
Query: 834 SLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPP----MPSSLSAEAQAFLLRTFEP 889
SLG VIEM G PP+ SP AM ++ + PP +S + FL R
Sbjct: 586 SLGIMVIEMVDGEPPYFS-DSPVQAMKRL---RDSPPPKLKNSHKVSPVLRDFLERMLVR 641
Query: 890 DPRLRASAQTLLGDPFL 906
DP+ RA+AQ LL PFL
Sbjct: 642 DPQERATAQELLDHPFL 658
>gi|9910476 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 140 bits (352), Expect = 1e-32
Identities = 90/257 (35%), Positives = 139/257 (54%), Gaps = 15/257 (5%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSAS 713
+G+G+ G+V R++H+ ++A+K + R + + L E+ + R +H N+V S
Sbjct: 413 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYL 472
Query: 714 QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIK 773
G L + ME + GG+L+ ++ V + NE I+ +LQ L YLH ++HRDIK
Sbjct: 473 VGEELWVLMEFLQGGALTDIVSQV----RLNEEQIATVCEAVLQALAYLHAQGVIHRDIK 528
Query: 774 GDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIW 833
D++L+ T G +K+SDFG +++ P ++ GT +MAPE+I + Y DIW
Sbjct: 529 SDSILL-TLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL--YATEVDIW 585
Query: 834 SLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPP----MPSSLSAEAQAFLLRTFEP 889
SLG VIEM G PP+ SP AM ++ + PP +S + FL R
Sbjct: 586 SLGIMVIEMVDGEPPYFS-DSPVQAMKRL---RDSPPPKLKNSHKVSPVLRDFLERMLVR 641
Query: 890 DPRLRASAQTLLGDPFL 906
DP+ RA+AQ LL PFL
Sbjct: 642 DPQERATAQELLDHPFL 658
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 138 bits (347), Expect = 4e-32
Identities = 92/257 (35%), Positives = 136/257 (52%), Gaps = 9/257 (3%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSAS 713
+G GTYG VY R+ +T AIK I + +EI + + +H NIV Y GS
Sbjct: 22 IGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYL 81
Query: 714 QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIK 773
+ L I ME GGSL + V GPL +E I++ +R+ LQGL YLH +HRDIK
Sbjct: 82 RRDKLWICMEFCGGGSLQDIYH-VTGPL--SELQIAYVSRETLQGLYYLHSKGKMHRDIK 138
Query: 774 GDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIID-QGPRGYGKAADI 832
G N+L+ T +G +K++DFG S ++ ++F GT +MAPE+ + GY + D+
Sbjct: 139 GANILL-TDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDL 197
Query: 833 WSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPM---PSSLSAEAQAFLLRTFEP 889
W++G T IE+A +PP +L P A+F + PP S F+
Sbjct: 198 WAVGITAIELAELQPPMFDL-HPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTK 256
Query: 890 DPRLRASAQTLLGDPFL 906
+P+ R +A+ LL PF+
Sbjct: 257 NPKKRPTAEKLLQHPFV 273
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 137 bits (346), Expect = 5e-32
Identities = 118/413 (28%), Positives = 177/413 (42%), Gaps = 52/413 (12%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSAS 713
LG G +G VY +++ T A K I + + EI + H IV+ LG+
Sbjct: 42 LGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYY 101
Query: 714 QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIK 773
G L I +E PGG++ +++ + L E I RQ+L+ L +LH I+HRD+K
Sbjct: 102 HDGKLWIMIEFCPGGAVDAIMLELDRGL--TEPQIQVVCRQMLEALNFLHSKRIIHRDLK 159
Query: 774 GDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEII---DQGPRGYGKAA 830
NVL+ T G ++++DFG S + ++F GT +MAPE++ Y A
Sbjct: 160 AGNVLM-TLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKA 218
Query: 831 DIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPP---MPSSLSAEAQAFLLRTF 887
DIWSLG T+IEMA PP HEL +P + ++ K PP PS S E + FL
Sbjct: 219 DIWSLGITLIEMAQIEPPHHEL-NPMRVLLKIA--KSDPPTLLTPSKWSVEFRDFLKIAL 275
Query: 888 EPDPRLRASAQTLLGDPFLQPGKRSRS---------------PSSPRHAPRPSDAPSASP 932
+ +P R SA LL PF+ +++ R DA A+
Sbjct: 276 DKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAAS 335
Query: 933 TPSANSTTQSQTFP--------------CPQAPSQHPPSPPKRCLSYGGTSQLRVPEEPA 978
T ++ S+ P P APSQ S + C G L+ P
Sbjct: 336 TLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPV 395
Query: 979 AEEPASPEESSGLSLLHQESKRRAMLAAVLEQELPALAENLHQEQKQEQGARL 1031
+P +GL++ K R + + A + ++Q EQG L
Sbjct: 396 ----VAPGNENGLAVPVPLRKSRPV-------SMDARIQVAQEKQVAEQGGDL 437
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 137 bits (345), Expect = 7e-32
Identities = 91/259 (35%), Positives = 134/259 (51%), Gaps = 11/259 (4%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSAS 713
+G+G G VY D T +AIK++ + + + EI + R ++ NIV YL S
Sbjct: 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 348
Query: 714 QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIK 773
G L + ME + GGSL+ ++ +E I+ R+ LQ L +LH N ++HRDIK
Sbjct: 349 VGDELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQALDFLHSNQVIHRDIK 404
Query: 774 GDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIW 833
DN+L+ G +K++DFG ++ T GT +MAPE++ + + YG DIW
Sbjct: 405 SDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIW 461
Query: 834 SLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPM--PSSLSAEAQAFLLRTFEPDP 891
SLG IEM G PP+ +P A++ + P + P LSA + FL R E D
Sbjct: 462 SLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGT-PELQNPERLSAVFRDFLNRCLEMDV 519
Query: 892 RLRASAQTLLGDPFLQPGK 910
R SA+ LL PFL+ K
Sbjct: 520 DRRGSAKELLQHPFLKLAK 538
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 137 bits (345), Expect = 7e-32
Identities = 91/259 (35%), Positives = 134/259 (51%), Gaps = 11/259 (4%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSAS 713
+G+G G VY D T +AIK++ + + + EI + R ++ NIV YL S
Sbjct: 295 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 354
Query: 714 QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIK 773
G L + ME + GGSL+ ++ +E I+ R+ LQ L +LH N ++HRDIK
Sbjct: 355 VGDELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQALDFLHSNQVIHRDIK 410
Query: 774 GDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIW 833
DN+L+ G +K++DFG ++ T GT +MAPE++ + + YG DIW
Sbjct: 411 SDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIW 467
Query: 834 SLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPM--PSSLSAEAQAFLLRTFEPDP 891
SLG IEM G PP+ +P A++ + P + P LSA + FL R E D
Sbjct: 468 SLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGT-PELQNPERLSAVFRDFLNRCLEMDV 525
Query: 892 RLRASAQTLLGDPFLQPGK 910
R SA+ LL PFL+ K
Sbjct: 526 DRRGSAKELLQHPFLKLAK 544
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 137 bits (345), Expect = 7e-32
Identities = 91/259 (35%), Positives = 134/259 (51%), Gaps = 11/259 (4%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSAS 713
+G+G G VY D T +AIK++ + + + EI + R ++ NIV YL S
Sbjct: 310 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 369
Query: 714 QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIK 773
G L + ME + GGSL+ ++ +E I+ R+ LQ L +LH N ++HRDIK
Sbjct: 370 VGDELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQALDFLHSNQVIHRDIK 425
Query: 774 GDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIW 833
DN+L+ G +K++DFG ++ T GT +MAPE++ + + YG DIW
Sbjct: 426 SDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIW 482
Query: 834 SLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPM--PSSLSAEAQAFLLRTFEPDP 891
SLG IEM G PP+ +P A++ + P + P LSA + FL R E D
Sbjct: 483 SLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGT-PELQNPERLSAVFRDFLNRCLEMDV 540
Query: 892 RLRASAQTLLGDPFLQPGK 910
R SA+ LL PFL+ K
Sbjct: 541 DRRGSAKELLQHPFLKLAK 559
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 137 bits (345), Expect = 7e-32
Identities = 91/259 (35%), Positives = 134/259 (51%), Gaps = 11/259 (4%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSAS 713
+G+G G VY D T +AIK++ + + + EI + R ++ NIV YL S
Sbjct: 274 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 333
Query: 714 QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIK 773
G L + ME + GGSL+ ++ +E I+ R+ LQ L +LH N ++HRDIK
Sbjct: 334 VGDELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQALDFLHSNQVIHRDIK 389
Query: 774 GDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIW 833
DN+L+ G +K++DFG ++ T GT +MAPE++ + + YG DIW
Sbjct: 390 SDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIW 446
Query: 834 SLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPM--PSSLSAEAQAFLLRTFEPDP 891
SLG IEM G PP+ +P A++ + P + P LSA + FL R E D
Sbjct: 447 SLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGT-PELQNPERLSAVFRDFLNRCLEMDV 504
Query: 892 RLRASAQTLLGDPFLQPGK 910
R SA+ LL PFL+ K
Sbjct: 505 DRRGSAKELLQHPFLKLAK 523
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 137 bits (345), Expect = 7e-32
Identities = 91/259 (35%), Positives = 134/259 (51%), Gaps = 11/259 (4%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSAS 713
+G+G G VY D T +AIK++ + + + EI + R ++ NIV YL S
Sbjct: 274 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 333
Query: 714 QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIK 773
G L + ME + GGSL+ ++ +E I+ R+ LQ L +LH N ++HRDIK
Sbjct: 334 VGDELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQALDFLHSNQVIHRDIK 389
Query: 774 GDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIW 833
DN+L+ G +K++DFG ++ T GT +MAPE++ + + YG DIW
Sbjct: 390 SDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIW 446
Query: 834 SLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPM--PSSLSAEAQAFLLRTFEPDP 891
SLG IEM G PP+ +P A++ + P + P LSA + FL R E D
Sbjct: 447 SLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGT-PELQNPERLSAVFRDFLNRCLEMDV 504
Query: 892 RLRASAQTLLGDPFLQPGK 910
R SA+ LL PFL+ K
Sbjct: 505 DRRGSAKELLQHPFLKLAK 523
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 137 bits (345), Expect = 7e-32
Identities = 91/259 (35%), Positives = 134/259 (51%), Gaps = 11/259 (4%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSAS 713
+G+G G VY D T +AIK++ + + + EI + R ++ NIV YL S
Sbjct: 274 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 333
Query: 714 QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIK 773
G L + ME + GGSL+ ++ +E I+ R+ LQ L +LH N ++HRDIK
Sbjct: 334 VGDELWVVMEYLAGGSLTDVVTETC----MDEGQIAAVCRECLQALDFLHSNQVIHRDIK 389
Query: 774 GDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIW 833
DN+L+ G +K++DFG ++ T GT +MAPE++ + + YG DIW
Sbjct: 390 SDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIW 446
Query: 834 SLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPM--PSSLSAEAQAFLLRTFEPDP 891
SLG IEM G PP+ +P A++ + P + P LSA + FL R E D
Sbjct: 447 SLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGT-PELQNPERLSAVFRDFLNRCLEMDV 504
Query: 892 RLRASAQTLLGDPFLQPGK 910
R SA+ LL PFL+ K
Sbjct: 505 DRRGSAKELLQHPFLKLAK 523
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 137 bits (344), Expect = 9e-32
Identities = 90/256 (35%), Positives = 130/256 (50%), Gaps = 9/256 (3%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSAS 713
+G GTYG VY RD T A+K + L +EI + R RH N+V Y+GS
Sbjct: 22 VGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVAYIGSYL 81
Query: 714 QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIK 773
+ L I ME GGSL + + GPL++ + I++ R+ L+GL +LH +HRDIK
Sbjct: 82 RNDRLWICMEFCGGGSLQEIYHAT-GPLEERQ--IAYVCREALKGLHHLHSQGKIHRDIK 138
Query: 774 GDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIID-QGPRGYGKAADI 832
G N+L+ T G +K++DFG S L +F GT +MAPE+ + GY + D+
Sbjct: 139 GANLLL-TLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDV 197
Query: 833 WSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQ---AFLLRTFEP 889
W+LG T IE+ +PP L P A+ + PP + Q FL
Sbjct: 198 WALGITAIELGELQPPLFHL-HPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTK 256
Query: 890 DPRLRASAQTLLGDPF 905
+P+ R +A+ LL PF
Sbjct: 257 NPKKRPTAEKLLQHPF 272
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 136 bits (343), Expect = 1e-31
Identities = 94/261 (36%), Positives = 139/261 (53%), Gaps = 15/261 (5%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSAS 713
LG+G+YG VY + T +AIK++P Q + +EI++ ++ ++V+Y GS
Sbjct: 36 LGEGSYGSVYKAIHKETGQIVAIKQVPVESDL--QEIIKEISIMQQCDSPHVVKYYGSYF 93
Query: 714 QGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIK 773
+ L I ME GS+S ++R L ++E I+ + L+GL YLH +HRDIK
Sbjct: 94 KNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDE--IATILQSTLKGLEYLHFMRKIHRDIK 151
Query: 774 GDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIW 833
N+L+NT G K++DFG + +L T GT +MAPE+I + GY ADIW
Sbjct: 152 AGNILLNT-EGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE--IGYNCVADIW 208
Query: 834 SLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPP----MPSSLSAEAQAFLLRTFEP 889
SLG T IEMA G+PP+ ++ P A+F M +PP P S F+ +
Sbjct: 209 SLGITAIEMAEGKPPYADI-HPMRAIF---MIPTNPPPTFRKPELWSDNFTDFVKQCLVK 264
Query: 890 DPRLRASAQTLLGDPFLQPGK 910
P RA+A LL PF++ K
Sbjct: 265 SPEQRATATQLLQHPFVRSAK 285
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 136 bits (343), Expect = 1e-31
Identities = 96/273 (35%), Positives = 140/273 (51%), Gaps = 15/273 (5%)
Query: 642 DYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLR 701
DYE + +G GTYG VY R+ HT A+K I + +EI + + +
Sbjct: 19 DYELVQR-----VGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
Query: 702 HKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGY 761
H NIV Y GS L I ME GGSL + V GPL +E I++ R+ LQGL Y
Sbjct: 74 HCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYH-VTGPL--SELQIAYVCRETLQGLAY 130
Query: 762 LHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIID- 820
LH +HRDIKG N+L+ T G +K++DFG + ++ ++F GT +MAPE+
Sbjct: 131 LHTKGKMHRDIKGANILL-TDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAV 189
Query: 821 QGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPM---PSSLSA 877
+ GY + DIW++G T IE+ +PP +L P A+F + PP + S+
Sbjct: 190 EKNGGYNQLCDIWAVGITAIELGELQPPMFDL-HPMRALFLMSKSNFQPPKLKDKTKWSS 248
Query: 878 EAQAFLLRTFEPDPRLRASAQTLLGDPFL-QPG 909
F+ +P+ R +A+ LL F+ QPG
Sbjct: 249 TFHNFVKIALTKNPKKRPTAERLLTHTFVAQPG 281
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 136 bits (343), Expect = 1e-31
Identities = 96/273 (35%), Positives = 140/273 (51%), Gaps = 15/273 (5%)
Query: 642 DYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLR 701
DYE + +G GTYG VY R+ HT A+K I + +EI + + +
Sbjct: 19 DYELVQR-----VGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
Query: 702 HKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGY 761
H NIV Y GS L I ME GGSL + V GPL +E I++ R+ LQGL Y
Sbjct: 74 HCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYH-VTGPL--SELQIAYVCRETLQGLAY 130
Query: 762 LHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIID- 820
LH +HRDIKG N+L+ T G +K++DFG + ++ ++F GT +MAPE+
Sbjct: 131 LHTKGKMHRDIKGANILL-TDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAV 189
Query: 821 QGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPM---PSSLSA 877
+ GY + DIW++G T IE+ +PP +L P A+F + PP + S+
Sbjct: 190 EKNGGYNQLCDIWAVGITAIELGELQPPMFDL-HPMRALFLMSKSNFQPPKLKDKTKWSS 248
Query: 878 EAQAFLLRTFEPDPRLRASAQTLLGDPFL-QPG 909
F+ +P+ R +A+ LL F+ QPG
Sbjct: 249 TFHNFVKIALTKNPKKRPTAERLLTHTFVAQPG 281
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 135 bits (341), Expect = 2e-31
Identities = 92/263 (34%), Positives = 139/263 (52%), Gaps = 12/263 (4%)
Query: 654 LGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFS-QPLHEEIALHRRLRHKNIVRYLGSA 712
+GKG++G V+ G D T+ +AIK I ++ + + +EI + + + +Y GS
Sbjct: 30 IGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSY 89
Query: 713 SQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDI 772
+G L I ME + GGS LLR+ GP +E I+ ++IL+GL YLH +HRDI
Sbjct: 90 LKGSKLWIIMEYLGGGSALDLLRA--GPF--DEFQIATMLKEILKGLDYLHSEKKIHRDI 145
Query: 773 KGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADI 832
K NVL++ G +K++DFG + +L TF GT +MAPE+I Q Y ADI
Sbjct: 146 KAANVLLSE-QGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQS--AYDSKADI 202
Query: 833 WSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPP-MPSSLSAEAQAFLLRTFEPDP 891
WSLG T IE+A G PP ++ P +F + K +PP + + + F+ DP
Sbjct: 203 WSLGITAIELAKGEPPNSDM-HPMRVLFLIP--KNNPPTLVGDFTKSFKEFIDACLNKDP 259
Query: 892 RLRASAQTLLGDPFLQPGKRSRS 914
R +A+ LL F+ + S
Sbjct: 260 SFRPTAKELLKHKFIVKNSKKTS 282
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,037,948
Number of Sequences: 37866
Number of extensions: 3014554
Number of successful extensions: 22092
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 657
Number of HSP's successfully gapped in prelim test: 759
Number of HSP's that attempted gapping in prelim test: 15505
Number of HSP's gapped (non-prelim): 4757
length of query: 1288
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1174
effective length of database: 13,930,794
effective search space: 16354752156
effective search space used: 16354752156
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.