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Search of human proteins with 45643138
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45643138 kelch-like 13 [Homo sapiens]
(655 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45643138 kelch-like 13 [Homo sapiens] 1342 0.0
gi|24308181 kelch-like 9 [Homo sapiens] 1181 0.0
gi|8922854 kelch-like 26 [Homo sapiens] 471 e-132
gi|31542246 kelch-like 36 [Homo sapiens] 420 e-117
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 379 e-105
gi|55741643 kelch-like 14 [Homo sapiens] 356 4e-98
gi|156616301 kelch-like 32 [Homo sapiens] 343 3e-94
gi|24432026 kelch-like [Homo sapiens] 341 1e-93
gi|226442729 kelch-like 15 [Homo sapiens] 311 2e-84
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 300 3e-81
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 300 3e-81
gi|40807500 kelch-like 20 [Homo sapiens] 283 5e-76
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 282 6e-76
gi|23397572 kelch-like 34 [Homo sapiens] 276 4e-74
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 273 4e-73
gi|55925604 kelch-like 18 [Homo sapiens] 270 2e-72
gi|166235129 kelch-like 3 [Homo sapiens] 268 2e-71
gi|14780904 kelch-like 1 protein [Homo sapiens] 267 3e-71
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 266 4e-71
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 266 4e-71
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 261 1e-69
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 261 1e-69
gi|38194229 kelch-like 17 [Homo sapiens] 254 2e-67
gi|11056006 kelch-like 12 [Homo sapiens] 248 2e-65
gi|148664209 kelch-like 10 [Homo sapiens] 242 9e-64
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 234 2e-61
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 234 2e-61
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 221 1e-57
gi|40018614 DRE1 protein [Homo sapiens] 221 1e-57
gi|109150407 kelch-like 6 [Homo sapiens] 218 2e-56
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 1342 bits (3473), Expect = 0.0
Identities = 655/655 (100%), Positives = 655/655 (100%)
Query: 1 MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQS 60
MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQS
Sbjct: 1 MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQS 60
Query: 61 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK 120
SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK
Sbjct: 61 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK 120
Query: 121 AMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL 180
AMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL
Sbjct: 121 AMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL 180
Query: 181 DFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERL 240
DFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERL
Sbjct: 181 DFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERL 240
Query: 241 AFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVD 300
AFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVD
Sbjct: 241 AFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVD 300
Query: 301 FMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELR 360
FMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELR
Sbjct: 301 FMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELR 360
Query: 361 MYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK 420
MYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK
Sbjct: 361 MYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK 420
Query: 421 WMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYG 480
WMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYG
Sbjct: 421 WMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYG 480
Query: 481 HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVI 540
HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVI
Sbjct: 481 HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVI 540
Query: 541 GGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR 600
GGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR
Sbjct: 541 GGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR 600
Query: 601 CMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 655
CMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
Sbjct: 601 CMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 655
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 1181 bits (3056), Expect = 0.0
Identities = 569/613 (92%), Positives = 594/613 (96%)
Query: 43 MKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTD 102
MK+SLG EMG+S+HLQ KAG TR FTSNTHSSVVLQGFDQLR+EGLLCDVTL+PGD D
Sbjct: 1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGD 60
Query: 103 DAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMD 162
+ FPVHR MMASASDYFKAMFTGGMKEQDLMCIKLHGV+KVGL+KIIDFIYTAKLSLNMD
Sbjct: 61 EIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMD 120
Query: 163 NLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKN 222
NLQDTLEAASFLQILPVLDFCKVFLISGV+LDNCVEVGRIANTYNL EVDKYVN+F+LKN
Sbjct: 121 NLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKN 180
Query: 223 FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNI 282
FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKA CRWLRLE+PRMD+AAKLMKNI
Sbjct: 181 FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNI 240
Query: 283 RFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHL 342
RFPLMTPQ+LINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSD+THL
Sbjct: 241 RFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHL 300
Query: 343 VTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT 402
VTLGGVLRQQLVVSKELRMYDE+A EW+SLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT
Sbjct: 301 VTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT 360
Query: 403 KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYN 462
KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKG+LYAVGGR+AAGEL TVECYN
Sbjct: 361 KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYN 420
Query: 463 PRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMT 522
PR NEW+YVAKMSEPHYGHAGTVYGG+MYISGGITHDTFQ ELMCFDPDTDKW+QKAPMT
Sbjct: 421 PRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMT 480
Query: 523 TVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGV 582
TVRGLHCMCTVG++LYVIGGNHFRGTSDYDDVLSCEYYSP LDQWTPIAAMLRGQSDVGV
Sbjct: 481 TVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGV 540
Query: 583 AVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEET 642
AVFENKIYVVGGYSWNNRCMVEIVQKYDP+KDEWHKVFDLPESLGGIRACTLTVFPPEE
Sbjct: 541 AVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEEN 600
Query: 643 TPSPSRESPLSAP 655
SPSRESPLSAP
Sbjct: 601 PGSPSRESPLSAP 613
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 471 bits (1211), Expect = e-132
Identities = 249/574 (43%), Positives = 354/574 (61%), Gaps = 8/574 (1%)
Query: 69 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMK 128
F++ +HS+ +LQG LR +G L DV L +AFP H+V++A+ SDYF+AMFTGGM+
Sbjct: 40 FSAPSHSTSLLQGLATLRAQGQLLDVVLTINR--EAFPAHKVVLAACSDYFRAMFTGGMR 97
Query: 129 EQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 188
E I+L GVS GLR IIDF Y+A+++L++D +QD L AA FLQ+LPV++ C+ FL
Sbjct: 98 EASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLK 157
Query: 189 SGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNS 248
+ ++++ C+ +G++A T++L + + V++F ++F + +FL+LP ERL F L SN
Sbjct: 158 AAMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNR 217
Query: 249 LKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTC 308
L+ C E++LF+A RWL+ + R A+ ++ +IRFPLM EL++ VQT+D M D C
Sbjct: 218 LQSCAEIDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLC 277
Query: 309 VNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVL---RQQLVVSKELRMYDEK 365
LLEA NYQ++P+ Q MQS RTA+RSD LVT GG + V SK ++ +
Sbjct: 278 RQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPG 337
Query: 366 AHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVA 425
A ++ L M+ +AV+ NF+YV GGQ G+ AVD +R+DP N+W+++
Sbjct: 338 ARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQ 397
Query: 426 SLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTV 485
++ E R F L+ L G +YA GGRN AG L +VE Y PR NEW Y + +GHAG
Sbjct: 398 AMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAA 457
Query: 486 YGGVMYISGGITHDTFQKE-LMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNH 544
GG +YISGG K+ L C+DP D+W KAPM+ R LH M G R+Y +GG
Sbjct: 458 SGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRM 517
Query: 545 FRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVE 604
+ DVL+ EYY P DQWT ++ M GQS+ G + E KIY+VGGY+W +
Sbjct: 518 DHVDRCF-DVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTG 576
Query: 605 IVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFP 638
IVQ Y+ D DEW + PES GI AC + P
Sbjct: 577 IVQVYNTDTDEWERDLHFPESFAGI-ACAPVLLP 609
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 420 bits (1079), Expect = e-117
Identities = 221/585 (37%), Positives = 353/585 (60%), Gaps = 13/585 (2%)
Query: 66 TRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTG 125
++++ HSS VLQ ++ RL GL CDV L+ + P HR ++A SDYF +MFT
Sbjct: 20 SKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADE--QRVPAHRNLLAVCSDYFNSMFTI 77
Query: 126 GMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKV 185
GM+E ++L G S +GL+ ++DF+Y +L L+ N+ LE A LQI V+DFC
Sbjct: 78 GMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCE 137
Query: 186 FLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLK-LPFERLAFVL 244
+L V+ DN + + +A+ Y+L +D +++ F+L +F L T +FL+ + ++L L
Sbjct: 138 YLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYL 197
Query: 245 SSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTV--DFM 302
SS+ ++ E +L +A +WL + R A ++++NI FPL+ +L++ V+ +
Sbjct: 198 SSSEVQRECEHDLLQAALQWLTQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLL 257
Query: 303 RTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQ-LVVSKELRM 361
+ C + EA Y QPVMQ+ RTA+R++ L+ +GG + ++ L +S +
Sbjct: 258 PKEANCEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCY 317
Query: 362 YDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421
D K+ +W P+ A R H +AV+G F+++ GG + D G A + ++R+DPR +W
Sbjct: 318 LDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQW 377
Query: 422 MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGH 481
++VAS+N++R F+L++++ L A+GGRN G L +VE Y+P+T+ W+YVA + YGH
Sbjct: 378 IKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGH 437
Query: 482 AGTVYGGVMYISGGITHD----TFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERL 537
AGT+Y +YISGG HD ++K L+C+D TD W ++ PMTT RG H MC++G+ +
Sbjct: 438 AGTIYKDFVYISGG--HDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSI 495
Query: 538 YVIGGNHFRGTS-DYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYS 596
Y IGG+ S + DVL E YSP +QWT +A +L S+ GVAV+E +IY++GGYS
Sbjct: 496 YSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYS 555
Query: 597 WNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEE 641
W N + VQ YD + D+W + DLP+++ G AC + P E
Sbjct: 556 WENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVCALEPRPE 600
>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
sapiens]
Length = 634
Score = 379 bits (973), Expect = e-105
Identities = 210/613 (34%), Positives = 333/613 (54%), Gaps = 25/613 (4%)
Query: 48 GGSEMG-LSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFP 106
GG+ + +SS L + GP +L+G ++R E LCD+ + G +F
Sbjct: 39 GGNGLSCISSELTDASYGPN-----------LLEGLSKMRQENFLCDLVI--GTKTKSFD 85
Query: 107 VHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQD 166
VH+ +MAS S+YF + K+ + + L+ +S +GL +I + YT KL+L++ +
Sbjct: 86 VHKSVMASCSEYFYNILK---KDPSIQRVDLNDISPLGLATVIAYAYTGKLTLSLYTIGS 142
Query: 167 TLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPAL 226
+ AA +LQI ++ C FLI ++++NC+ V IA TY+L F+ NF
Sbjct: 143 IISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEF 202
Query: 227 LSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPL 286
+ +F+KL FE++ +L + L+ +E+ F+ +WL ++ R+ +AA L+ NIRF
Sbjct: 203 AESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMKWLEFDQKRVKYAADLLSNIRFGT 262
Query: 287 MTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLG 346
++ Q+L+NYVQ+V M D C LL++A NY ++PY Q +QS RT IR LVT+G
Sbjct: 263 ISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVG 322
Query: 347 GVLRQQLVVSKELR--MYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKG 404
G R L R +Y + + W L M A + +AV+ FLYV GG+ D +
Sbjct: 323 G--RPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARN 380
Query: 405 --KTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYN 462
K AV R+DPR+N W+ +AS+N+KRT F LS G +YA GGRNA G L ++ECY
Sbjct: 381 QAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYV 440
Query: 463 PRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMT 522
P TN+W + HA V G + ++GG + + + + +DP +D W + ++
Sbjct: 441 PSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLS 500
Query: 523 TVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGV 582
T RG HC T+ +R+YV+GG+ + DVL+ E YSP QW+ A + G S GV
Sbjct: 501 TPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGV 560
Query: 583 AVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEET 642
+ + Y+VGG++ + + +Q + P+ +EW + +LPE+ G+ CTL++ P
Sbjct: 561 SALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWTEDDELPEATVGVSCCTLSM--PNNV 618
Query: 643 TPSPSRESPLSAP 655
T S S P
Sbjct: 619 TRESRASSVSSVP 631
>gi|55741643 kelch-like 14 [Homo sapiens]
Length = 628
Score = 356 bits (913), Expect = 4e-98
Identities = 214/633 (33%), Positives = 327/633 (51%), Gaps = 68/633 (10%)
Query: 61 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK 120
S++G +HS +L G + L + L CDVTL F H+ ++AS S YF+
Sbjct: 2 SRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTA--QGQQFHCHKAVLASCSQYFR 59
Query: 121 AMFT------GGMKEQD------------------------------------------- 131
++F+ GG+ QD
Sbjct: 60 SLFSSHPPLGGGVGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSP 119
Query: 132 --LMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLIS 189
+ + L G S +GLR +++++YTA ++L++D +++ L + L I V C FL
Sbjct: 120 RAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLND 179
Query: 190 GVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSL 249
+++ N +V +IA + L E K N ++++ + L L FE + +L S
Sbjct: 180 QISVQNYKQVCKIAALHGLEETKKLANKYLVE---------DVLLLNFEEMRALLDSLPP 230
Query: 250 KHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTC 308
+EL LF+ + WL + E RM +A LMK +RF L+ EL+ VQ+VDFMRTD C
Sbjct: 231 PVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVC 290
Query: 309 VNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLR-QQLVVSKELRMYDEKAH 367
LLL+A NY +MP+ Q QS + IRS+ L+ +GG+ + S ++ YD++
Sbjct: 291 QKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKK 350
Query: 368 EWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASL 427
WK L M H + + NFL+V+GG+ ++ GK + + V R+DPR+N W+Q+ +
Sbjct: 351 TWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPM 410
Query: 428 NEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYG 487
E+R F+ L +LY +GGRN G L +VECYN TNEW YV+ + +P HAG V+
Sbjct: 411 QERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHN 470
Query: 488 GVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRG 547
G +YISGG+ + + L C+DP D W +K M T R +H + + +RLY IGGNH +G
Sbjct: 471 GKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKG 530
Query: 548 TSDYDDVLSCEYYSPILDQWTPI-AAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIV 606
S + DV+ E Y P DQW + +L G+S G AV ++ IY+VGGYSW+
Sbjct: 531 FS-HLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSST 589
Query: 607 QKYDPDKDEWHKV-FDLPESLGGIRACTLTVFP 638
Y P+K W ++ D+ E L G AC + P
Sbjct: 590 ICYCPEKGTWTELEGDVAEPLAG-PACVTVILP 621
>gi|156616301 kelch-like 32 [Homo sapiens]
Length = 620
Score = 343 bits (880), Expect = 3e-94
Identities = 214/586 (36%), Positives = 322/586 (54%), Gaps = 23/586 (3%)
Query: 67 RIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGG 126
R+ S +H+ VL +Q R +G+LCD+TL+ + F H+ ++A+ SDYF+AMF+
Sbjct: 17 RLCHSESHNDSVLAALNQQRSDGILCDITLIA--EEQKFHAHKAVLAACSDYFRAMFSLC 74
Query: 127 MKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVF 186
M E + LHGV+ +GL++ ++F YT ++ L +QD L A S LQ+L +L+ C +
Sbjct: 75 MVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHY 134
Query: 187 LISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLST--GEFLKLPFERLAFVL 244
LI + N +++ R+A+ +NLT ++K V F++K+ LL + E L LP+ L VL
Sbjct: 135 LIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVL 194
Query: 245 SSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRT 304
S+ L +E ++++ RWL + +L++ IRF LM L + ++
Sbjct: 195 KSDRLTSLSEEQIWQLAVRWLE-HNCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQA 253
Query: 305 DNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDE 364
T L+ EA Y Y QPV Q+ RT R + L +GG R+ V KELR ++
Sbjct: 254 SETATALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKV-KELRYFNP 312
Query: 365 KAHE---------WKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFD 415
E W LAPM R H +AV+G+FL+V GG+ + + AV T R+D
Sbjct: 313 VDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYD 372
Query: 416 PRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGE-LPTVECYNPRTNEWTYVAKM 474
PR N W ++A + R F L A++ YLYAVGGRN + LPTVE Y P+ N+WT+V
Sbjct: 373 PRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSF 432
Query: 475 SEPHYGHAGTVYGGVMYISGGITHDT-FQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTV 533
HAG V G+++ISGG+T+ +Q LM ++P+ +KWI ++PM R H M V
Sbjct: 433 DRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAV 492
Query: 534 GERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPI-AAMLRGQSDVGVAVFENKIYVV 592
+LYV+GGN +D V + Y+ DQWT +L GQ++ GVAV +IY+V
Sbjct: 493 QRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLV 552
Query: 593 GGYS-WNNRCMVEIVQKYDPDKDEWHKVF---DLPESLGGIRACTL 634
GGYS W N + +Q D ++ +VF LP + GI AC L
Sbjct: 553 GGYSIWTNEPLA-CIQVLDVSREGKEEVFYGPTLPFASNGIAACFL 597
>gi|24432026 kelch-like [Homo sapiens]
Length = 634
Score = 341 bits (874), Expect = 1e-93
Identities = 205/596 (34%), Positives = 323/596 (54%), Gaps = 22/596 (3%)
Query: 69 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMK 128
+ S HS +L+G LR G+L DV L+ HR+++A++ DYF+ MF GG+K
Sbjct: 27 YRSAQHSQALLRGLLALRDSGILFDVVLVVEGRH--IEAHRILLAASCDYFRGMFAGGLK 84
Query: 129 EQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 188
E + + +HGVS + +I+ FIYT++L L++ N+Q+TL AA LQI ++ FC FL+
Sbjct: 85 EMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLM 144
Query: 189 SGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNS 248
S V +N ++V R+A ++L+ + + +++++LKNF A T ++ +LP E++ +LSSN
Sbjct: 145 SWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNR 204
Query: 249 LKHCTELELFKATCRW-LRLEEPRMDFAA-----KLMKNIRFPLMTPQELINYVQTVDFM 302
L+ E E+++ + LE+ + D + KL++ +RFPLM + L +D
Sbjct: 205 LEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLDPS 264
Query: 303 RTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGV-LRQQLVVSKELRM 361
+T + L+ Y +QP +QS +T +RSD +V GG+ V+S + +
Sbjct: 265 PLRDTVASALM----YHRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQAKY 320
Query: 362 YDEKAHEWKSLAPMDAPRYQH-GIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK 420
+ EWK APR + GIAV+ NF+Y++GG +N +G A +R+DPR+N+
Sbjct: 321 LNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNN--VQGFRAESRCWRYDPRHNR 378
Query: 421 WMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYG 480
W Q+ SL ++ + + Y+YAV GR+ +L VE Y+P TN W YVA + Y
Sbjct: 379 WFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYA 438
Query: 481 HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVI 540
HAG G MYI+ G + + KE C+DP ++ W A R H M T+ +LYVI
Sbjct: 439 HAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVI 498
Query: 541 GGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR 600
GG++ DV YS QW+ + + G + G+AV +N+IYV+GG S N
Sbjct: 499 GGSN-NDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRG 557
Query: 601 CMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLT-----VFPPEETTPSPSRESP 651
V YD +KD W + L S+ G+ AC LT + P TP S+ P
Sbjct: 558 SRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLPRSLLLEPPRGTPDRSQADP 613
>gi|226442729 kelch-like 15 [Homo sapiens]
Length = 604
Score = 311 bits (796), Expect = 2e-84
Identities = 191/594 (32%), Positives = 309/594 (52%), Gaps = 27/594 (4%)
Query: 63 AGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAM 122
AG F S+ H + V GF L EGLL DVTL+ D F H+ ++A+ SDYF+ M
Sbjct: 2 AGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVI--EDHQFQAHKALLATQSDYFRIM 59
Query: 123 FTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDF 182
FT M+E+D I L G++ G ++ F+Y + L+M+ + + L+AA ++Q++ V+ F
Sbjct: 60 FTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKF 119
Query: 183 CKVFLISGVTLDNCVEVGRIANTY--NLTEVDKYVNSFVLKNFPALLSTGEFLK-LPFER 239
C FL++ + L+NC E+ R+ + + N+ V + +++F+L NF L+S +FL L FE+
Sbjct: 120 CCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEK 179
Query: 240 LAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTV 299
L L ++ L E+EL++A WLR + R +++NIRF LMTP + V+T
Sbjct: 180 LMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTS 239
Query: 300 DFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKEL 359
+F R + +A NY + QP++ + IRS G++ +V SK L
Sbjct: 240 EFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKIL 299
Query: 360 RMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYN 419
+ +K W L P +A++ NF++++GG+ A VFR+DPR N
Sbjct: 300 LL--KKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQN 357
Query: 420 KWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHY 479
W+Q+A ++ R+ F + + ++YAV GR + E Y+ ++W +V Y
Sbjct: 358 SWLQMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKY 417
Query: 480 GHAGTVYGGVMYISGGITHDTFQKELMCFDPD---------------TDKWIQKAPMTTV 524
GH GTV ++I+GGIT + K++ FDP T+ W K+ M
Sbjct: 418 GHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYA 477
Query: 525 RGLHCMCTVGERLYVIGG--NHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGV 582
R H M + +LYV GG R + + S E Y+P DQWT +A+M G+S GV
Sbjct: 478 RCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGV 537
Query: 583 AVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW--HKVFDLPESLGGIRACTL 634
V + +I V+GG +N I+ +DPD+++W + +P L G++ C L
Sbjct: 538 TVLDKQIMVLGGLCYNGHYSDSIL-TFDPDENKWKEDEYPRMPCKLDGLQVCNL 590
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 300 bits (768), Expect = 3e-81
Identities = 194/604 (32%), Positives = 302/604 (50%), Gaps = 19/604 (3%)
Query: 37 EEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTL 96
E E S LSS F + H+ + + LCDV L
Sbjct: 119 ENESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVIL 178
Query: 97 MPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAK 156
+ GD P HR++++S SDYF AMFT ++E IK+ GV L +I + YT +
Sbjct: 179 VAGDR--RIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGR 236
Query: 157 LSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVN 216
L L DN++ L A LQ+ V++ C FL+ + NC+ + A+ T++ K +
Sbjct: 237 LELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAH 296
Query: 217 SFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLR--LEEPRMDF 274
++ +++F ++ EF+ LP +A +L+S+ + E + A W+R LE+ R D
Sbjct: 297 NYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDL 356
Query: 275 AAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTA 334
+KL+ IR PL+ PQ L + V F R D C L++EA Y ++P +P++QS RT
Sbjct: 357 -SKLLAYIRLPLLAPQFLADMENNVLF-RDDIECQKLIMEAMKYHLLPERRPMLQSPRTK 414
Query: 335 IRSDTT-HLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYV 393
R T L +GG+ + S + YD + + W +A M+ R Q G+AV+ + LYV
Sbjct: 415 PRKSTVGTLFAVGGMDSTKGATS--IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYV 472
Query: 394 VGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAG 453
VGG+ G ++TV ++P+ W + ++ R ++ L+G +YAVGG +
Sbjct: 473 VGGRD-----GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS 527
Query: 454 ELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTD 513
L TVE ++P+ +W +VA MS P V G +Y GG + K + CFDP T+
Sbjct: 528 YLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTN 587
Query: 514 KWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSC-EYYSPILDQWTPIAA 572
KW A M+ RG + T LY IGG+ ++ + C E Y P D WT +A+
Sbjct: 588 KWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVAS 647
Query: 573 MLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRAC 632
M + VGV + +K+Y VGGY + + + V+ YDP +EW +V P LG AC
Sbjct: 648 MSISRDAVGVCLLGDKLYAVGGY--DGQAYLNTVEAYDPQTNEWTQV--APLCLGRAGAC 703
Query: 633 TLTV 636
+TV
Sbjct: 704 VVTV 707
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 300 bits (768), Expect = 3e-81
Identities = 194/604 (32%), Positives = 302/604 (50%), Gaps = 19/604 (3%)
Query: 37 EEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTL 96
E E S LSS F + H+ + + LCDV L
Sbjct: 165 ENESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVIL 224
Query: 97 MPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAK 156
+ GD P HR++++S SDYF AMFT ++E IK+ GV L +I + YT +
Sbjct: 225 VAGDR--RIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGR 282
Query: 157 LSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVN 216
L L DN++ L A LQ+ V++ C FL+ + NC+ + A+ T++ K +
Sbjct: 283 LELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAH 342
Query: 217 SFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLR--LEEPRMDF 274
++ +++F ++ EF+ LP +A +L+S+ + E + A W+R LE+ R D
Sbjct: 343 NYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDL 402
Query: 275 AAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTA 334
+KL+ IR PL+ PQ L + V F R D C L++EA Y ++P +P++QS RT
Sbjct: 403 -SKLLAYIRLPLLAPQFLADMENNVLF-RDDIECQKLIMEAMKYHLLPERRPMLQSPRTK 460
Query: 335 IRSDTT-HLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYV 393
R T L +GG+ + S + YD + + W +A M+ R Q G+AV+ + LYV
Sbjct: 461 PRKSTVGTLFAVGGMDSTKGATS--IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYV 518
Query: 394 VGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAG 453
VGG+ G ++TV ++P+ W + ++ R ++ L+G +YAVGG +
Sbjct: 519 VGGRD-----GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS 573
Query: 454 ELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTD 513
L TVE ++P+ +W +VA MS P V G +Y GG + K + CFDP T+
Sbjct: 574 YLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTN 633
Query: 514 KWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSC-EYYSPILDQWTPIAA 572
KW A M+ RG + T LY IGG+ ++ + C E Y P D WT +A+
Sbjct: 634 KWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVAS 693
Query: 573 MLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRAC 632
M + VGV + +K+Y VGGY + + + V+ YDP +EW +V P LG AC
Sbjct: 694 MSISRDAVGVCLLGDKLYAVGGY--DGQAYLNTVEAYDPQTNEWTQV--APLCLGRAGAC 749
Query: 633 TLTV 636
+TV
Sbjct: 750 VVTV 753
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 283 bits (723), Expect = 5e-76
Identities = 176/572 (30%), Positives = 302/572 (52%), Gaps = 24/572 (4%)
Query: 52 MGLSSHLQSSKAGPTRI-FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRV 110
+G + L P R+ + S+ H L+ + LR LCDV L+ G HRV
Sbjct: 27 LGDPNKLPEGVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKK--IYAHRV 84
Query: 111 MMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEA 170
++++ S YF+AMFTG + E + + + + + +IDF YT+++++ N+Q L A
Sbjct: 85 ILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPA 144
Query: 171 ASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTG 230
A LQ+ + + C FL + NC+ + A+T++ E+ + + F NF ++ +
Sbjct: 145 ACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESE 204
Query: 231 EFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTP 289
EF+ LP +L ++SS+ L +E ++F A W++ + R ++++++R PL++P
Sbjct: 205 EFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSP 264
Query: 290 QELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDT---THLVTLG 346
+ L+ V + +++D C +L+ EA NY ++P +P+MQ RT R L +G
Sbjct: 265 KFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVG 324
Query: 347 GVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKT 406
G + S E YD + +EW+ +A M R G++V+ + LY VGG G +
Sbjct: 325 GWCSGDAISSVE--RYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHD-----GSS 377
Query: 407 AVDTVFRFDPRYNKW-MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRT 465
+++V R+DP+ N+W VA + RT ++ L G+LYAVGG++ L VE Y+P+
Sbjct: 378 YLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKE 437
Query: 466 NEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVR 525
N+WT VA MS G A V GG +Y GG + + ++P ++W APM T R
Sbjct: 438 NKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGT-R 496
Query: 526 GLHCMCTV-GERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAV 584
H C V + +Y +GG D ++ S E Y+P +QW+P+ AM +S VG+AV
Sbjct: 497 RKHLGCAVYQDMIYAVGGR-----DDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAV 551
Query: 585 FENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW 616
++ VGG+ + ++ ++ +DPD + W
Sbjct: 552 VNGQLMAVGGF--DGTTYLKTIEVFDPDANTW 581
Score = 94.0 bits (232), Expect = 4e-19
Identities = 58/182 (31%), Positives = 93/182 (51%), Gaps = 16/182 (8%)
Query: 443 LYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQ 502
L+AVGG + + +VE Y+P+TNEW VA MS+ G +V ++Y GG ++
Sbjct: 320 LFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYL 379
Query: 503 KELMCFDPDTDKWIQK-APMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSC---- 557
+ +DP T++W AP +T R + +G LY +GG D +SC
Sbjct: 380 NSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQ---------DGVSCLNIV 430
Query: 558 EYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWH 617
E Y P ++WT +A+M + V VAV +Y VGG + + V++Y+P ++ WH
Sbjct: 431 ERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSP--LNTVERYNPQENRWH 488
Query: 618 KV 619
+
Sbjct: 489 TI 490
Score = 71.2 bits (173), Expect = 3e-12
Identities = 40/137 (29%), Positives = 68/137 (49%), Gaps = 22/137 (16%)
Query: 362 YDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421
Y+ + + W ++APM R G AV + +Y VGG+ + T + + R++PR N+W
Sbjct: 480 YNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDD-----TTELSSAERYNPRTNQW 534
Query: 422 MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGH 481
V ++ +R+ L+ + G L AVGG + L T+E ++P N W
Sbjct: 535 SPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTW------------- 581
Query: 482 AGTVYGGVMY--ISGGI 496
+YGG+ Y + GG+
Sbjct: 582 --RLYGGMNYRRLGGGV 596
Score = 58.5 bits (140), Expect = 2e-08
Identities = 43/152 (28%), Positives = 73/152 (48%), Gaps = 8/152 (5%)
Query: 487 GGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFR 546
G V++ GG + +DP T++W A M+ R + + + LY +GG+
Sbjct: 317 GEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHD-- 374
Query: 547 GTSDYDDVLSCEYYSPILDQWTP-IAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEI 605
G+S + V E Y P +QW+ +A ++ VGVAV +Y VGG + + I
Sbjct: 375 GSSYLNSV---ERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQ--DGVSCLNI 429
Query: 606 VQKYDPDKDEWHKVFDLPESLGGIRACTLTVF 637
V++YDP +++W +V + G+ L F
Sbjct: 430 VERYDPKENKWTRVASMSTRRLGVAVAVLGGF 461
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 282 bits (722), Expect = 6e-76
Identities = 177/532 (33%), Positives = 280/532 (52%), Gaps = 17/532 (3%)
Query: 109 RVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTL 168
R++++S SDYF AMFT ++E IK+ GV L +I + YT +L L DN++ L
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 169 EAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLS 228
A LQ+ V++ C FL+ + NC+ + A+ T++ K +++ +++F ++
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 229 TGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLR--LEEPRMDFAAKLMKNIRFPL 286
EF+ LP +A +L+S+ + E + A W+R LE+ R D +KL+ IR PL
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDL-SKLLAYIRLPL 352
Query: 287 MTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTT-HLVTL 345
+ PQ L + V F R D C L++EA Y ++P +P++QS RT R T L +
Sbjct: 353 LAPQFLADMENNVLF-RDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAV 411
Query: 346 GGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGK 405
GG+ + S + YD + + W +A M+ R Q G+AV+ + LYVVGG+ G
Sbjct: 412 GGMDSTKGATS--IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD-----GL 464
Query: 406 TAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRT 465
++TV ++P+ W + ++ R ++ L+G +YAVGG + L TVE ++P+
Sbjct: 465 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQA 524
Query: 466 NEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVR 525
+W +VA MS P V G +Y GG + K + CFDP T+KW A M+ R
Sbjct: 525 RQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRR 584
Query: 526 GLHCMCTVGERLYVIGGNHFRGTSDYDDVLSC-EYYSPILDQWTPIAAMLRGQSDVGVAV 584
G + T LY IGG+ ++ + C E Y P D WT +A+M + VGV +
Sbjct: 585 GGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCL 644
Query: 585 FENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTV 636
+K+Y VGGY + + + V+ YDP +EW +V P LG AC +TV
Sbjct: 645 LGDKLYAVGGY--DGQAYLNTVEAYDPQTNEWTQV--APLCLGRAGACVVTV 692
>gi|23397572 kelch-like 34 [Homo sapiens]
Length = 644
Score = 276 bits (706), Expect = 4e-74
Identities = 190/621 (30%), Positives = 288/621 (46%), Gaps = 70/621 (11%)
Query: 74 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLM 133
H +L G+ LR EG LCDVTL ++ FP HR ++A +SDYF+A+F +E
Sbjct: 11 HGGALLTGYQALRAEGFLCDVTLETEGSE--FPAHRSLLACSSDYFRALFKSHTQESRAR 68
Query: 134 CIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTL 193
I LH S GL++++DFIYTA LSL+MD ++DTLEAAS+LQ+ L C +L +
Sbjct: 69 VIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAP 128
Query: 194 DNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGE----FLKLPFERLAFVLSSNSL 249
+NC +A + L ++ + LL+ G L+L L VL + +
Sbjct: 129 ENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDV 188
Query: 250 KHCTELELFKATCRWLRLE--EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNT 307
E L WLR E R+ +L++ +RF L+ P +++ V + +
Sbjct: 189 ARVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLV-PADVLRRVYSGSGLVLPAR 247
Query: 308 CVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVV------------ 355
L+++A NY P QP+MQ ++T+IRS T ++ +GG +++V+
Sbjct: 248 VKGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARG 307
Query: 356 -------------------------SKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNF 390
++ + +D H W+SL + P H + GNF
Sbjct: 308 QVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNF 367
Query: 391 LYVVGGQSNYDTKGKTAVD-------TVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYL 443
L+V+GG+S + D V R+DPR++ W +V ++ E R F A+ L
Sbjct: 368 LFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERL 427
Query: 444 YAVGGRNAAGE-LPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYG-GVMYISGGIT---- 497
AVGG A GE L +VE Y+ R + WT + +GHAG V GV+YISGG
Sbjct: 428 LAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGE 487
Query: 498 -HDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLS 556
+ ++L P+ W +KAPM T R G + V+ G F Y+
Sbjct: 488 GGASSLRDLYVLGPEEQVWSKKAPMGTAR-------FGHHMAVLRGAVFAFLGRYEPFSE 540
Query: 557 CEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEI--VQKYDPDKD 614
E Y P DQWT + + + G+AV E ++GG W + V V YD D D
Sbjct: 541 IERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLD 600
Query: 615 EWHKV-FDLPESLGGIRACTL 634
W + LP + G+R L
Sbjct: 601 RWEDIGCALPWAWSGLRCAVL 621
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 273 bits (698), Expect = 4e-73
Identities = 175/569 (30%), Positives = 280/569 (49%), Gaps = 17/569 (2%)
Query: 74 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLM 133
H+ L+ + E LCDV L+ G P HR+++++ SDYF AMFT + E
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHL--RIPAHRLVLSAVSDYFAAMFTNDVLEAKQE 221
Query: 134 CIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTL 193
+++ GV L ++ + YT L L D ++ L AA LQ+ V+D C FLI +
Sbjct: 222 EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHP 281
Query: 194 DNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 253
NC+ + + TE+ + + +++F ++ EFL LP ++ +L S+ +
Sbjct: 282 SNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPD 341
Query: 254 ELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 312
E +F A +W+ + + R L+ IR PL+ PQ L+ ++T D C LL
Sbjct: 342 EETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLL 400
Query: 313 LEASNYQMMPYMQPVMQSDRTAIRSDTT-HLVTLGGVLRQQLVVSKELRMYDEKAHEWKS 371
+EA Y ++P + +MQS RT R T L +GG+ + + + YD + + W
Sbjct: 401 MEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGM--DAMKGTTTIEKYDLRTNSWLH 458
Query: 372 LAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKR 431
+ M+ R Q G+AVI N LYVVGG+ G ++TV F+P W + ++ R
Sbjct: 459 IGTMNGRRLQFGVAVIDNKLYVVGGRD-----GLKTLNTVECFNPVGKIWTVMPPMSTHR 513
Query: 432 TFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMY 491
++ L+G +YAVGG + L TVE ++P +W YVA MS P +Y
Sbjct: 514 HGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLY 573
Query: 492 ISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDY 551
GG + K + FDP T+KW APM+ RG + T LYV+GG+ ++
Sbjct: 574 AIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHC 633
Query: 552 DDVLSC-EYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYD 610
+ C E Y P D W+ +A + + V V +K+YVVGGY + + V+ YD
Sbjct: 634 SRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY--DGHTYLNTVESYD 691
Query: 611 PDKDEWHKVFDLPESLGGIRACTLTVFPP 639
++EW + ++P ++G AC + V P
Sbjct: 692 AQRNEWKE--EVPVNIGRAGACVVVVKLP 718
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 270 bits (691), Expect = 2e-72
Identities = 178/552 (32%), Positives = 279/552 (50%), Gaps = 21/552 (3%)
Query: 83 DQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSK 142
+++R +G LCDVTL GD F HR+++A++ YF AMFT M E I + G+
Sbjct: 29 EEIRRQGKLCDVTLKIGD--HKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDP 86
Query: 143 VGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRI 202
L +I+F Y L+++ N+Q L ASFLQ+ + D C FL + NC+ V +
Sbjct: 87 SALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQF 146
Query: 203 ANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATC 262
A T + NSF+ ++F + + EFL LP E + ++S + L +E ++F+A
Sbjct: 147 AETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAAL 206
Query: 263 RWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMM 321
W+R + E R + +L+ NIR PL PQ L + VQ D +R + C +L+ EA +Y +M
Sbjct: 207 AWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLM 266
Query: 322 PYMQPVMQSDRTAIRSDTT--HLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPR 379
P +P + + RT R T+ L+ G L + ++D A+ W+ PM R
Sbjct: 267 PERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTAR 326
Query: 380 YQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSAL 439
+ G+AV+ LY +GG YD G+ + TV ++P + W +V S+N KR+ L
Sbjct: 327 SRVGVAVVNGLLYAIGG---YD--GQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVL 381
Query: 440 KGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHD 499
G +Y GG + L +VE Y+P T++WT V MS TV+ G +Y+SGG HD
Sbjct: 382 DGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGG--HD 439
Query: 500 TFQ--KELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSC 557
Q + ++ T W A M R H ++G +++V GG G +
Sbjct: 440 GLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGF-----LSIA 494
Query: 558 EYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWH 617
E YS + DQW I M +S V + ++Y VGGY + + + V+ YDP+ D W
Sbjct: 495 EMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGY--DGQSNLSSVEMYDPETDCWT 552
Query: 618 KVFDLPESLGGI 629
+ + GG+
Sbjct: 553 FMAPMACHEGGV 564
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 268 bits (684), Expect = 2e-71
Identities = 179/576 (31%), Positives = 286/576 (49%), Gaps = 68/576 (11%)
Query: 68 IFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGM 127
I + H + ++LR + LLCDV ++ D + HRV++A+ S YF AMFTG M
Sbjct: 26 ITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVE--IEAHRVVLAACSPYFCAMFTGDM 83
Query: 128 KEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 187
E I++ V L K+ID+IYTA++ + +N+Q L AAS LQ++ V C FL
Sbjct: 84 SESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFL 143
Query: 188 ISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSN 247
S + NC+ + A+ + T++ + N++ ++FP ++ EFL L +++ ++SS+
Sbjct: 144 QSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSD 203
Query: 248 SLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDN 306
L +E ++F+A W+ E E R++ AKLM+++R PL+ L+ V+ ++ +N
Sbjct: 204 KLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNN 263
Query: 307 TCVNLLLEASNYQMMPYMQPVM-QSDRTAIRSDTT------------------------- 340
TC + L+EA Y ++P Q ++ ++ RT R+ +
Sbjct: 264 TCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFE 323
Query: 341 ------------------------HLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMD 376
H+ +GG V + + +YD +W S+A M
Sbjct: 324 EDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRV--RTVDVYDGVKDQWTSIASMQ 381
Query: 377 APRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHL 436
R G AV+ + LY VGG +D G T + +V + + N+W VA +N +R+ +
Sbjct: 382 ERRSTLGAAVLNDLLYAVGG---FD--GSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGV 436
Query: 437 SALKGYLYAVGGRNAAGE--LPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISG 494
++G LYAVGG + A L TVE YNP TNEW YVA MS G V G +Y +G
Sbjct: 437 GVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATG 496
Query: 495 GITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDV 554
G +K + +DP T+ W Q A M R +C V LYV+GG+ ++
Sbjct: 497 GHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGD-----DGSCNL 551
Query: 555 LSCEYYSPILDQWTPIAA-MLRGQSDVGVAVFENKI 589
S EYY+P+ D+WT + M G+S GVAV +
Sbjct: 552 ASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHKSL 587
Score = 82.4 bits (202), Expect = 1e-15
Identities = 58/192 (30%), Positives = 92/192 (47%), Gaps = 8/192 (4%)
Query: 438 ALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVY-GGVMYISGGI 496
+L + VGG+ A + +VECY+ + W +A++ AG V+ G +Y GG
Sbjct: 298 SLPKVMIVVGGQ-APKAIRSVECYDFEEDRWDQIAELPSRRC-RAGVVFMAGHVYAVGGF 355
Query: 497 THDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLS 556
+ + +D D+W A M R + + LY +GG F G++ + S
Sbjct: 356 NGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGG--FDGSTG---LAS 410
Query: 557 CEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW 616
E YS ++W +A M +S VGV V E K+Y VGGY +R + V++Y+P +EW
Sbjct: 411 VEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEW 470
Query: 617 HKVFDLPESLGG 628
V D+ G
Sbjct: 471 IYVADMSTRRSG 482
Score = 40.0 bits (92), Expect = 0.007
Identities = 24/81 (29%), Positives = 34/81 (41%), Gaps = 2/81 (2%)
Query: 554 VLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDK 613
+ S E Y D+W IA + + GV +Y VGG+ N V V YD K
Sbjct: 314 IRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGF--NGSLRVRTVDVYDGVK 371
Query: 614 DEWHKVFDLPESLGGIRACTL 634
D+W + + E + A L
Sbjct: 372 DQWTSIASMQERRSTLGAAVL 392
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 267 bits (682), Expect = 3e-71
Identities = 180/604 (29%), Positives = 297/604 (49%), Gaps = 29/604 (4%)
Query: 44 KLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDD 103
+LS G M S L SS + + + H+ + + + LCDV L+ G+
Sbjct: 166 RLSSTGHSMTPQSDLDSSSS--EEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRK- 222
Query: 104 AFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDN 163
P HR++++S SDYF AMFT + E IK+ G+ L ++ F YT L L D
Sbjct: 223 -IPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDT 281
Query: 164 LQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNF 223
+++ L AA LQ+ V++ C FL+ + NC+ + A+ E+ K +S+ ++N
Sbjct: 282 IENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENI 341
Query: 224 PALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNI 282
++ EFL LP E L +L+S+ + E +F A W++ + + R + + L+ I
Sbjct: 342 MEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFI 401
Query: 283 RFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTT-H 341
R PL+ PQ L + ++ + D C L+LEA Y ++P + +MQS RT R T
Sbjct: 402 RLPLLPPQILAD-LENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGT 460
Query: 342 LVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYD 401
L +GG+ + + + YD + + W M+ R Q G+AVI + L+V+GG+
Sbjct: 461 LYAVGGMDNNKGATT--IEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRD--- 515
Query: 402 TKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECY 461
G ++TV ++P+ W + ++ R ++ L+G +YAVGG + L TVE +
Sbjct: 516 --GLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERW 573
Query: 462 NPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPM 521
+P++ +WT+VA MS G +Y GG + + +DP T+KW APM
Sbjct: 574 DPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPM 633
Query: 522 TTVRGLHCMCTVGERLYVIGG------NHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLR 575
RG + T LY +GG NH DY E Y P D WT +A +
Sbjct: 634 CKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDY-----VERYDPKTDTWTMVAPLSM 688
Query: 576 GQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLT 635
+ VGV + +++Y VGGY + + + ++ YDP +EW ++ L ++G AC +
Sbjct: 689 PRDAVGVCLLGDRLYAVGGY--DGQTYLNTMESYDPQTNEWTQMASL--NIGRAGACVVV 744
Query: 636 VFPP 639
+ P
Sbjct: 745 IKQP 748
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 266 bits (680), Expect = 4e-71
Identities = 169/546 (30%), Positives = 268/546 (49%), Gaps = 15/546 (2%)
Query: 74 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLM 133
H+ L+ + E LCDV L+ G P HR+++++ SDYF AMFT + E
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHL--RIPAHRLVLSAVSDYFAAMFTNDVLEAKQE 221
Query: 134 CIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTL 193
+++ GV L ++ + YT L L D ++ L AA LQ+ V+D C FLI +
Sbjct: 222 EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHP 281
Query: 194 DNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 253
NC+ + + TE+ + + +++F ++ EFL LP ++ +L S+ +
Sbjct: 282 SNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPD 341
Query: 254 ELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 312
E +F A +W+ + + R L+ IR PL+ PQ L+ ++T D C LL
Sbjct: 342 EETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLL 400
Query: 313 LEASNYQMMPYMQPVMQSDRTAIRSDTT-HLVTLGGVLRQQLVVSKELRMYDEKAHEWKS 371
+EA Y ++P + +MQS RT R T L +GG+ + + + YD + + W
Sbjct: 401 MEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGM--DAMKGTTTIEKYDLRTNSWLH 458
Query: 372 LAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKR 431
+ M+ R Q G+AVI N LYVVGG+ G ++TV F+P W + ++ R
Sbjct: 459 IGTMNGRRLQFGVAVIDNKLYVVGGRD-----GLKTLNTVECFNPVGKIWTVMPPMSTHR 513
Query: 432 TFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMY 491
++ L+G +YAVGG + L TVE ++P +W YVA MS P +Y
Sbjct: 514 HGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLY 573
Query: 492 ISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDY 551
GG + K + FDP T+KW APM+ RG + T LYV+GG+ ++
Sbjct: 574 AIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHC 633
Query: 552 DDVLSC-EYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYD 610
+ C E Y P D W+ +A + + V V +K+YVVGGY + + V+ YD
Sbjct: 634 SRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY--DGHTYLNTVESYD 691
Query: 611 PDKDEW 616
++EW
Sbjct: 692 AQRNEW 697
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 266 bits (680), Expect = 4e-71
Identities = 175/551 (31%), Positives = 277/551 (50%), Gaps = 16/551 (2%)
Query: 71 SNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQ 130
++ HS +LQG + LR LCD+ L GD H+V++AS S YFKAMFTG + E+
Sbjct: 14 THLHSEQLLQGLNLLRQHHELCDIILRVGDVK--IHAHKVVLASVSPYFKAMFTGNLSEK 71
Query: 131 DLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISG 190
+ ++ + + L+ I+++ YT + ++ D ++ L AA+ LQI VL C FL S
Sbjct: 72 ENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQ 131
Query: 191 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLK 250
+ NC+ + R A TY ++ ++ +NF A+ T EF +L L ++S++ L
Sbjct: 132 LDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLN 191
Query: 251 HCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCV 309
TE +F A W++ + + R + A+L+ ++R PL++ + L + +R D TC
Sbjct: 192 VATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCK 251
Query: 310 NLLLEASNYQMMPYMQPVMQSD-RTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHE 368
+LL EA Y MP + Q+ T R L +GG + MY +
Sbjct: 252 HLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGG-KSGLFACLDSVEMYFPQNDS 310
Query: 369 WKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTA---VDTVFRFDPRYNKWMQVA 425
W LAP++ PRY+ GI V+ +YV+GG + G T ++V ++P N W +
Sbjct: 311 WIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLE 370
Query: 426 SLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTV 485
+NE R+ + L G LYA+GG + L +VE Y P+ +W VA M+ A V
Sbjct: 371 RMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAV 430
Query: 486 YGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHF 545
G++Y GG + +DP D W A M R + + ++V+GG++
Sbjct: 431 LDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHN- 488
Query: 546 RGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEI 605
G S + S E Y P +QWT M ++ VG AV +N +YVVGG+S ++ +
Sbjct: 489 -GVS---HLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSS--YLNT 542
Query: 606 VQKYDPDKDEW 616
VQKYDP D W
Sbjct: 543 VQKYDPISDTW 553
Score = 112 bits (281), Expect = 8e-25
Identities = 60/193 (31%), Positives = 94/193 (48%), Gaps = 13/193 (6%)
Query: 342 LVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYD 401
L LGG Q + S E Y K +W+ +APM R AV+ +Y +GG
Sbjct: 388 LYALGGYDGQSYLQSVE--KYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY---- 441
Query: 402 TKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECY 461
G +++V R+DP + W VAS+ +KR F + + G+++ VGG N L ++E Y
Sbjct: 442 --GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERY 499
Query: 462 NPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPM 521
+P N+WT M EP G V +Y+ GG + ++ + +DP +D W+ A M
Sbjct: 500 DPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGM 559
Query: 522 TTVRGLHCMCTVG 534
++C C G
Sbjct: 560 -----IYCRCNFG 567
Score = 85.1 bits (209), Expect = 2e-16
Identities = 56/191 (29%), Positives = 87/191 (45%), Gaps = 17/191 (8%)
Query: 443 LYAVGGRNAAGE-LPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDT- 500
L AVGG++ L +VE Y P+ + W +A ++ P Y V +Y+ GGI +
Sbjct: 285 LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVR 344
Query: 501 -------FQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDD 553
+ + C++PDT+ W M R + + LY +GG + G S
Sbjct: 345 PGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGG--YDGQSYLQS 402
Query: 554 VLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDK 613
V E Y P + +W P+A M +S AV + IY +GGY + V++YDP K
Sbjct: 403 V---EKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYG---PAHMNSVERYDPSK 456
Query: 614 DEWHKVFDLPE 624
D W V + +
Sbjct: 457 DSWEMVASMAD 467
Score = 55.5 bits (132), Expect = 2e-07
Identities = 31/81 (38%), Positives = 44/81 (54%), Gaps = 5/81 (6%)
Query: 359 LRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRY 418
+ YD ++W PM PR G AVI N+LYVVGG S G + ++TV ++DP
Sbjct: 496 IERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHS-----GSSYLNTVQKYDPIS 550
Query: 419 NKWMQVASLNEKRTFFHLSAL 439
+ W+ A + R F L+AL
Sbjct: 551 DTWLDSAGMIYCRCNFGLTAL 571
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 261 bits (668), Expect = 1e-69
Identities = 167/553 (30%), Positives = 286/553 (51%), Gaps = 30/553 (5%)
Query: 74 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLM 133
H + ++LR + LLCDVT++ D + HRV++A+ S YF AMFTG M E
Sbjct: 42 HMKKAFKVMNELRSQNLLCDVTIVAEDME--ISAHRVVLAACSPYFHAMFTGEMSESRAK 99
Query: 134 CIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTL 193
+++ V LR +ID++YTA++ + +N+Q L AA LQ+ V C FL S +
Sbjct: 100 RVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 159
Query: 194 DNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 253
NC+ + A+ + T++ N++ ++F ++ + EFL L E++ ++SS+ L +
Sbjct: 160 VNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISS 219
Query: 254 ELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 312
E ++F+A W+ + + R +F A+LM+++R PL+ + L+ V+ ++ + C + L
Sbjct: 220 EEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYL 279
Query: 313 LEASNYQMMPYMQPV-MQSDRTAIRSDTT---HLVTLGGVLRQQLVVSKELRMYDEKAHE 368
+EA Y ++P Q + M+S RT +R+ +V +GG Q + + YD K
Sbjct: 280 IEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG---QAPKAIRSVECYDFKEER 336
Query: 369 WKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLN 428
W +A + + R + G+ + ++ VGG G V TV +DP ++W VA++
Sbjct: 337 WHQVAELPSRRCRAGMVYMAGLVFAVGG-----FNGSLRVRTVDSYDPVKDQWTSVANMR 391
Query: 429 EKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGG 488
++R+ + L G LYAVGG + + L +VE YN ++NEW +VA M+ V GG
Sbjct: 392 DRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGG 451
Query: 489 VMYISGGITHDTFQ--KELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFR 546
++Y GG + Q + C++ T++W A M+T R + + LY +GG
Sbjct: 452 LLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG---- 507
Query: 547 GTSDYDDVL---SCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 603
+D L S E Y P + W +A M + + GV +YVVGG + C +
Sbjct: 508 ----HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD--DGSCNL 561
Query: 604 EIVQKYDPDKDEW 616
V+ Y+P D+W
Sbjct: 562 ASVEYYNPTTDKW 574
Score = 79.7 bits (195), Expect = 8e-15
Identities = 44/122 (36%), Positives = 61/122 (50%), Gaps = 5/122 (4%)
Query: 362 YDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421
Y+ +EW +A M R G+ V+ N LY VGG G +V +DP N W
Sbjct: 473 YNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-----GPLVRKSVEVYDPTTNAW 527
Query: 422 MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGH 481
QVA +N R + A+ G LY VGG + + L +VE YNP T++WT V+ +
Sbjct: 528 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSY 587
Query: 482 AG 483
AG
Sbjct: 588 AG 589
Score = 74.3 bits (181), Expect = 3e-13
Identities = 53/187 (28%), Positives = 84/187 (44%), Gaps = 7/187 (3%)
Query: 443 LYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVY-GGVMYISGGITHDTF 501
L V G A + +VECY+ + W VA++ AG VY G+++ GG
Sbjct: 312 LMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRC-RAGMVYMAGLVFAVGGFNGSLR 370
Query: 502 QKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYS 561
+ + +DP D+W A M R + LY +GG F G++ V E Y+
Sbjct: 371 VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGG--FDGSTGLSSV---EAYN 425
Query: 562 PILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFD 621
++W +A M +S VGV V +Y VGGY +R + V+ Y+ +EW + +
Sbjct: 426 IKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAE 485
Query: 622 LPESLGG 628
+ G
Sbjct: 486 MSTRRSG 492
Score = 38.1 bits (87), Expect = 0.026
Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 2/81 (2%)
Query: 554 VLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDK 613
+ S E Y ++W +A + + G+ ++ VGG+ N V V YDP K
Sbjct: 324 IRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGF--NGSLRVRTVDSYDPVK 381
Query: 614 DEWHKVFDLPESLGGIRACTL 634
D+W V ++ + + A L
Sbjct: 382 DQWTSVANMRDRRSTLGAAVL 402
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 261 bits (668), Expect = 1e-69
Identities = 167/553 (30%), Positives = 286/553 (51%), Gaps = 30/553 (5%)
Query: 74 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLM 133
H + ++LR + LLCDVT++ D + HRV++A+ S YF AMFTG M E
Sbjct: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDME--ISAHRVVLAACSPYFHAMFTGEMSESRAK 95
Query: 134 CIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTL 193
+++ V LR +ID++YTA++ + +N+Q L AA LQ+ V C FL S +
Sbjct: 96 RVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 155
Query: 194 DNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 253
NC+ + A+ + T++ N++ ++F ++ + EFL L E++ ++SS+ L +
Sbjct: 156 VNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISS 215
Query: 254 ELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 312
E ++F+A W+ + + R +F A+LM+++R PL+ + L+ V+ ++ + C + L
Sbjct: 216 EEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYL 275
Query: 313 LEASNYQMMPYMQPV-MQSDRTAIRSDTT---HLVTLGGVLRQQLVVSKELRMYDEKAHE 368
+EA Y ++P Q + M+S RT +R+ +V +GG Q + + YD K
Sbjct: 276 IEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG---QAPKAIRSVECYDFKEER 332
Query: 369 WKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLN 428
W +A + + R + G+ + ++ VGG G V TV +DP ++W VA++
Sbjct: 333 WHQVAELPSRRCRAGMVYMAGLVFAVGG-----FNGSLRVRTVDSYDPVKDQWTSVANMR 387
Query: 429 EKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGG 488
++R+ + L G LYAVGG + + L +VE YN ++NEW +VA M+ V GG
Sbjct: 388 DRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGG 447
Query: 489 VMYISGGITHDTFQ--KELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFR 546
++Y GG + Q + C++ T++W A M+T R + + LY +GG
Sbjct: 448 LLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG---- 503
Query: 547 GTSDYDDVL---SCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 603
+D L S E Y P + W +A M + + GV +YVVGG + C +
Sbjct: 504 ----HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD--DGSCNL 557
Query: 604 EIVQKYDPDKDEW 616
V+ Y+P D+W
Sbjct: 558 ASVEYYNPTTDKW 570
Score = 79.7 bits (195), Expect = 8e-15
Identities = 44/122 (36%), Positives = 61/122 (50%), Gaps = 5/122 (4%)
Query: 362 YDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421
Y+ +EW +A M R G+ V+ N LY VGG G +V +DP N W
Sbjct: 469 YNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-----GPLVRKSVEVYDPTTNAW 523
Query: 422 MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGH 481
QVA +N R + A+ G LY VGG + + L +VE YNP T++WT V+ +
Sbjct: 524 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSY 583
Query: 482 AG 483
AG
Sbjct: 584 AG 585
Score = 74.3 bits (181), Expect = 3e-13
Identities = 53/187 (28%), Positives = 84/187 (44%), Gaps = 7/187 (3%)
Query: 443 LYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVY-GGVMYISGGITHDTF 501
L V G A + +VECY+ + W VA++ AG VY G+++ GG
Sbjct: 308 LMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRC-RAGMVYMAGLVFAVGGFNGSLR 366
Query: 502 QKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYS 561
+ + +DP D+W A M R + LY +GG F G++ V E Y+
Sbjct: 367 VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGG--FDGSTGLSSV---EAYN 421
Query: 562 PILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFD 621
++W +A M +S VGV V +Y VGGY +R + V+ Y+ +EW + +
Sbjct: 422 IKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAE 481
Query: 622 LPESLGG 628
+ G
Sbjct: 482 MSTRRSG 488
Score = 38.1 bits (87), Expect = 0.026
Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 2/81 (2%)
Query: 554 VLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDK 613
+ S E Y ++W +A + + G+ ++ VGG+ N V V YDP K
Sbjct: 320 IRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGF--NGSLRVRTVDSYDPVK 377
Query: 614 DEWHKVFDLPESLGGIRACTL 634
D+W V ++ + + A L
Sbjct: 378 DQWTSVANMRDRRSTLGAAVL 398
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 254 bits (649), Expect = 2e-67
Identities = 180/598 (30%), Positives = 290/598 (48%), Gaps = 25/598 (4%)
Query: 61 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK 120
S+ G + S H ++R GLLCD+ L + H+V++AS S YF
Sbjct: 61 SREGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKE--IRAHKVVLASCSPYFH 118
Query: 121 AMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL 180
AMFT M E + LH + L +++ F YTA++ + N+Q L AAS LQ+ V
Sbjct: 119 AMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVR 178
Query: 181 DFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERL 240
D C FL+S + NC+ + A+ ++ +++ K + +VL++F + T EF+ LP +++
Sbjct: 179 DACCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQV 238
Query: 241 AFVLSSNSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTV 299
++SS+SL +E E+++A W++ + + R +LMK +R PL++ L+ +V
Sbjct: 239 LELVSSDSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAE 298
Query: 300 DFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIR---SDTTHLVTLGGVLRQQLVVS 356
+R C +LL+EA + ++P + V+ + RT R L +GG +
Sbjct: 299 SLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGG--GSLFAIH 356
Query: 357 KELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDP 416
+ YD + W +A M R + G+A +GN LY VGG YD G + + TV +DP
Sbjct: 357 GDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGG---YD--GTSDLATVESYDP 411
Query: 417 RYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMS- 475
N W S+ +R+ ++AL G LY+ GG + A L + E Y+P T WT VA MS
Sbjct: 412 VTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMST 471
Query: 476 EPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGE 535
Y T+ G +Y GG + + ++P + W A M + R + +
Sbjct: 472 RRRYVRVATLDGN-LYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEG 530
Query: 536 RLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGY 595
LYV GGN GTS + V E YSP W +A M +S + + +Y VGG
Sbjct: 531 ALYVAGGND--GTSCLNSV---ERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGN 585
Query: 596 SWNNRCMVEIVQKYDPDKDEW---HKVFDLPESLGGIRACTLTVFPPEETTPSPSRES 650
++ + ++KY+P ++W +F S+G L PP T S S S
Sbjct: 586 DGSS--SLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTS 641
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 248 bits (632), Expect = 2e-65
Identities = 156/567 (27%), Positives = 271/567 (47%), Gaps = 16/567 (2%)
Query: 71 SNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQ 130
+NTH+ +L + LR LCDVTL D FP HR+++A+ SDYF AMFT + E+
Sbjct: 12 TNTHAKSILNSMNSLRKSNTLCDVTLRVEQKD--FPAHRIVLAACSDYFCAMFTSELSEK 69
Query: 131 DLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISG 190
+ + G++ + ++DF+YT + + ++N+Q+ L AA LQ+ V C FL S
Sbjct: 70 GKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQ 129
Query: 191 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLK 250
+ NC+ + A T+N ++ + F K+FP ++ EF+ L + ++ + ++
Sbjct: 130 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQ 189
Query: 251 HCTELELFKATCRWLR-LEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCV 309
+E +F+A W++ ++ R + L++ +R PL+TP+ + + + F+R C
Sbjct: 190 VDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCR 249
Query: 310 NLLLEASNYQMMPYMQPVMQSDRTAIRSDTTH-LVTLGGVLRQQLVVSKELRMYDEKAHE 368
+L+ EA + + P ++ MQ RT R L+ +GG QQ + + YD K E
Sbjct: 250 DLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPID-VVEKYDPKTQE 308
Query: 369 WKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGK-TAVDTVFRFDPRYNKWMQVASL 427
W L + R + + +YV+GG YD + + ++V+ + W VA +
Sbjct: 309 WSFLPSITRKRRYVASVSLHDRIYVIGG---YDGRSRLSSVECLDYTADEDGVWYSVAPM 365
Query: 428 NEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYG 487
N +R + L +Y GG + + ++E Y+P ++W+ + M G V
Sbjct: 366 NVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVAS 425
Query: 488 GVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRG 547
GV+Y GG + +DP T W PM T R + + + +YV+GG F G
Sbjct: 426 GVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGG--FDG 483
Query: 548 TSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQ 607
T+ V E Y+ D WT + +M + VG V ++Y + GY N+ ++ ++
Sbjct: 484 TAHLSSV---EAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNS--LLSSIE 538
Query: 608 KYDPDKDEWHKVFDLPESLGGIRACTL 634
YDP D W V + C L
Sbjct: 539 CYDPIIDSWEVVTSMGTQRCDAGVCVL 565
Score = 93.6 bits (231), Expect = 5e-19
Identities = 53/178 (29%), Positives = 81/178 (45%), Gaps = 5/178 (2%)
Query: 359 LRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRY 418
+ YD +W L M R G+ V +Y +GG YD G +++V ++DP
Sbjct: 396 MERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGG---YD--GLNILNSVEKYDPHT 450
Query: 419 NKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPH 478
W V + KR+ ++ L ++Y VGG + L +VE YN RT+ WT V M+ P
Sbjct: 451 GHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPR 510
Query: 479 YGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGER 536
TV G +Y G ++ + C+DP D W M T R +C + E+
Sbjct: 511 CYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLREK 568
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 242 bits (617), Expect = 9e-64
Identities = 157/567 (27%), Positives = 274/567 (48%), Gaps = 23/567 (4%)
Query: 75 SSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMC 134
S++ + F++LRLEG LCDV + + F H+ ++ S S YF+A+FT G +
Sbjct: 22 SAMACEIFNELRLEGKLCDVVIKVNGFE--FSAHKNILCSCSSYFRALFTSGWNNTEKKV 79
Query: 135 IKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLD 194
+ G+S ++ II++ YT + + DN++ L AA I+ ++ C FL S + LD
Sbjct: 80 YNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLD 139
Query: 195 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLS-TGEFLKLPFERLAFVLSSNSLKHCT 253
NC+ + + + Y E+ + F+L NF ++ + EFL+L L ++ + L
Sbjct: 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQ 199
Query: 254 ELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 312
E +F+A +W+ + + R + L+ +R LM + +N V+ D+++ C ++
Sbjct: 200 EDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVI 259
Query: 313 LEASNYQMMPYMQPVMQSD----RTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHE 368
+ A M SD T R L +GG + + YD +A
Sbjct: 260 INALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGS--PTNAIEAYDARADR 317
Query: 369 WKSLA-PMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASL 427
W ++ ++PR HG A + ++Y++GG + D ++V RFDP W QVA +
Sbjct: 318 WVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDY-----FNSVKRFDPVKKTWHQVAPM 372
Query: 428 NEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYG 487
+ +R + ++ L ++YA+GG + L T E Y P TN+WT +A M E + T
Sbjct: 373 HSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLY 432
Query: 488 GVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRG 547
G +YI GG + ++ ++++W APM + R + GE +Y +GG F G
Sbjct: 433 GKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGG--FDG 490
Query: 548 TSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQ 607
+ + S E YSP+ + W I M +S+ G+ V ++ ++VVGG+ N V+
Sbjct: 491 A---NRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGF--NGFTTTFNVE 545
Query: 608 KYDPDKDEWHKVFDLPESLGGIRACTL 634
YD DEW+ D+ + C +
Sbjct: 546 CYDEKTDEWYDAHDMSIYRSALSCCVV 572
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 234 bits (596), Expect = 2e-61
Identities = 155/574 (27%), Positives = 260/574 (45%), Gaps = 18/574 (3%)
Query: 60 SSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDA---FPVHRVMMASAS 116
S T +T H+ ++LRL LCDVTL D F H+V++AS+S
Sbjct: 45 SQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSS 104
Query: 117 DYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQI 176
FKAMFT G++EQ + + + G+ + ++I+F YTA +S+ + + A QI
Sbjct: 105 PVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQI 164
Query: 177 LPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLP 236
V+ C FL+ + N + + A E+ + ++ +F + EF L
Sbjct: 165 DSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLS 224
Query: 237 FERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINY 295
+L ++S + L E E+F A W++ + E R + L++ +R +TP L
Sbjct: 225 HCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQ 284
Query: 296 VQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVV 355
+Q + +++D+ C + L++ ++ + +P A + + T GG RQ L
Sbjct: 285 LQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPKVGRL-IYTAGGYFRQSL-- 339
Query: 356 SKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFD 415
L Y+ W LA + PR V+G LY VGG++N G T + ++
Sbjct: 340 -SYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN-SPDGNTDSSALDCYN 397
Query: 416 PRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMS 475
P N+W A ++ R + + G++YAVGG + +VE Y P +EW VA M
Sbjct: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPML 457
Query: 476 EPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGE 535
G V ++Y GG C+ P+ ++W M T+R +C +
Sbjct: 458 TRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHN 517
Query: 536 RLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGY 595
+Y G G D + S E Y + WT +A M +S +G+ V + +IYV+GGY
Sbjct: 518 CIYAAG-----GYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGY 572
Query: 596 SWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGI 629
+ ++ V+ YDPD D W +V + G+
Sbjct: 573 --DGHTFLDSVECYDPDTDTWSEVTRMTSGRSGV 604
Score = 100 bits (248), Expect = 6e-21
Identities = 62/196 (31%), Positives = 94/196 (47%), Gaps = 12/196 (6%)
Query: 443 LYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITH---- 498
+Y GG L +E YNP W +A + P G AG V GG++Y GG +
Sbjct: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 499 DTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCE 558
+T L C++P T++W APM+ R + + +Y +GG+H G ++ V E
Sbjct: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSH--GCIHHNSV---E 441
Query: 559 YYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHK 618
Y P D+W +A ML + VGVAV +Y VGG+ NR + + Y P+++EW
Sbjct: 442 RYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR--LNSAECYYPERNEWRM 499
Query: 619 VFDLPESLGGIRACTL 634
+ + G C L
Sbjct: 500 ITAMNTIRSGAGVCVL 515
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 234 bits (596), Expect = 2e-61
Identities = 155/574 (27%), Positives = 260/574 (45%), Gaps = 18/574 (3%)
Query: 60 SSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDA---FPVHRVMMASAS 116
S T +T H+ ++LRL LCDVTL D F H+V++AS+S
Sbjct: 45 SQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSS 104
Query: 117 DYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQI 176
FKAMFT G++EQ + + + G+ + ++I+F YTA +S+ + + A QI
Sbjct: 105 PVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQI 164
Query: 177 LPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLP 236
V+ C FL+ + N + + A E+ + ++ +F + EF L
Sbjct: 165 DSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLS 224
Query: 237 FERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINY 295
+L ++S + L E E+F A W++ + E R + L++ +R +TP L
Sbjct: 225 HCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQ 284
Query: 296 VQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVV 355
+Q + +++D+ C + L++ ++ + +P A + + T GG RQ L
Sbjct: 285 LQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPKVGRL-IYTAGGYFRQSL-- 339
Query: 356 SKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFD 415
L Y+ W LA + PR V+G LY VGG++N G T + ++
Sbjct: 340 -SYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN-SPDGNTDSSALDCYN 397
Query: 416 PRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMS 475
P N+W A ++ R + + G++YAVGG + +VE Y P +EW VA M
Sbjct: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPML 457
Query: 476 EPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGE 535
G V ++Y GG C+ P+ ++W M T+R +C +
Sbjct: 458 TRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHN 517
Query: 536 RLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGY 595
+Y G G D + S E Y + WT +A M +S +G+ V + +IYV+GGY
Sbjct: 518 CIYAAG-----GYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGY 572
Query: 596 SWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGI 629
+ ++ V+ YDPD D W +V + G+
Sbjct: 573 --DGHTFLDSVECYDPDTDTWSEVTRMTSGRSGV 604
Score = 100 bits (248), Expect = 6e-21
Identities = 62/196 (31%), Positives = 94/196 (47%), Gaps = 12/196 (6%)
Query: 443 LYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITH---- 498
+Y GG L +E YNP W +A + P G AG V GG++Y GG +
Sbjct: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 499 DTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCE 558
+T L C++P T++W APM+ R + + +Y +GG+H G ++ V E
Sbjct: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSH--GCIHHNSV---E 441
Query: 559 YYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHK 618
Y P D+W +A ML + VGVAV +Y VGG+ NR + + Y P+++EW
Sbjct: 442 RYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR--LNSAECYYPERNEWRM 499
Query: 619 VFDLPESLGGIRACTL 634
+ + G C L
Sbjct: 500 ITAMNTIRSGAGVCVL 515
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 221 bits (564), Expect = 1e-57
Identities = 145/500 (29%), Positives = 254/500 (50%), Gaps = 28/500 (5%)
Query: 127 MKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVF 186
M E +++ V LR +ID++YTA++ + +N+Q L AA LQ+ V C F
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 187 LISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSS 246
L S + NC+ + A+ + T++ N++ ++F ++ + EFL L E++ ++SS
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 247 NSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTD 305
+ L +E ++F+A W+ + + R +F A+LM+++R PL+ + L+ V+ ++
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
Query: 306 NTCVNLLLEASNYQMMPYMQPV-MQSDRTAIRSDTT---HLVTLGGVLRQQLVVSKELRM 361
+ C + L+EA Y ++P Q + M+S RT +R+ +V +GG Q + +
Sbjct: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG---QAPKAIRSVEC 237
Query: 362 YDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421
YD K W +A + + R + G+ + ++ VGG G V TV +DP ++W
Sbjct: 238 YDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGG-----FNGSLRVRTVDSYDPVKDQW 292
Query: 422 MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGH 481
VA++ ++R+ + L G LYAVGG + + L +VE YN ++NEW +VA M+
Sbjct: 293 TSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSV 352
Query: 482 AGTVYGGVMYISGGITHDTFQ--KELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYV 539
V GG++Y GG + Q + C++ T++W A M+T R + + LY
Sbjct: 353 GVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYA 412
Query: 540 IGGNHFRGTSDYDDVL---SCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYS 596
+GG +D L S E Y P + W +A M + + GV +YVVGG
Sbjct: 413 VGG--------HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD- 463
Query: 597 WNNRCMVEIVQKYDPDKDEW 616
+ C + V+ Y+P D+W
Sbjct: 464 -DGSCNLASVEYYNPTTDKW 482
Score = 74.3 bits (181), Expect = 3e-13
Identities = 53/187 (28%), Positives = 84/187 (44%), Gaps = 7/187 (3%)
Query: 443 LYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVY-GGVMYISGGITHDTF 501
L V G A + +VECY+ + W VA++ AG VY G+++ GG
Sbjct: 220 LMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRC-RAGMVYMAGLVFAVGGFNGSLR 278
Query: 502 QKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYS 561
+ + +DP D+W A M R + LY +GG F G++ V E Y+
Sbjct: 279 VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGG--FDGSTGLSSV---EAYN 333
Query: 562 PILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFD 621
++W +A M +S VGV V +Y VGGY +R + V+ Y+ +EW + +
Sbjct: 334 IKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAE 393
Query: 622 LPESLGG 628
+ G
Sbjct: 394 MSTRRSG 400
Score = 38.1 bits (87), Expect = 0.026
Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 2/81 (2%)
Query: 554 VLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDK 613
+ S E Y ++W +A + + G+ ++ VGG+ N V V YDP K
Sbjct: 232 IRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGF--NGSLRVRTVDSYDPVK 289
Query: 614 DEWHKVFDLPESLGGIRACTL 634
D+W V ++ + + A L
Sbjct: 290 DQWTSVANMRDRRSTLGAAVL 310
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 221 bits (564), Expect = 1e-57
Identities = 151/548 (27%), Positives = 262/548 (47%), Gaps = 30/548 (5%)
Query: 70 TSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKE 129
+ ++H+ +LQ F++ R L DV + + FP HR ++++ S YF+AMF +E
Sbjct: 44 SGSSHAENILQIFNEFRDSRLFTDVIICVEGKE--FPCHRAVLSACSSYFRAMFCNDHRE 101
Query: 130 QDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLIS 189
M ++++G+ + + ++YT K+ + +N+Q E +S QI + D C FL
Sbjct: 102 SREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEE 161
Query: 190 GVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSL 249
+ NC+ + R A+T++L + +F L+ F + EFL+L + L + S+ L
Sbjct: 162 QLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDEL 221
Query: 250 KHCTELELFKATCRWL-RLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTC 308
E +F+A RW+ R + R +L+ ++R PL+ P + V+ ++ C
Sbjct: 222 VIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPEC 281
Query: 309 VNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTH---LVTLGGVLRQQLVVSKELRMYDEK 365
LL EA Y + + M S RT R T + +V +GG R YD
Sbjct: 282 YQLLHEARRYHI---LGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPV 338
Query: 366 AHEWKSLAPM-DAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQV 424
EWKSLA + + + ++ + + N + V GG+ N V+ ++ + N W++V
Sbjct: 339 TGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRIN--------SRDVWIYNSQLNIWIRV 390
Query: 425 ASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGT 484
ASLN+ R ++ L G +Y VGG + L +VECY+ +N WT VA + E A T
Sbjct: 391 ASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVT 450
Query: 485 VYGGVMYISGGITHD-TFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN 543
G +++ GG D T ++ +DP+T+ W+ +A + + ++ +YV GG
Sbjct: 451 SCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG- 509
Query: 544 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 603
+ C Y P+ D W + Q + G++V KIY++GG N
Sbjct: 510 -------LTKAIYC--YDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEA-T 559
Query: 604 EIVQKYDP 611
+ + YDP
Sbjct: 560 DTILCYDP 567
Score = 74.3 bits (181), Expect = 3e-13
Identities = 50/177 (28%), Positives = 83/177 (46%), Gaps = 12/177 (6%)
Query: 443 LYAVGGRNAAG--ELPTVECYNPRTNEWTYVAKMSE-PHYGHAGTVYGGVMYISGGITHD 499
+ VGG G LP ECY+P T EW +AK+ E +A + +SGG +
Sbjct: 315 IVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINS 374
Query: 500 TFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEY 559
+++ ++ + WI+ A + R H M + ++YV+GG + + S E
Sbjct: 375 ---RDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGY-----DGQNRLSSVEC 426
Query: 560 YSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW 616
Y ++WT +A + S V K++V+GG +N C + VQ YDP+ + W
Sbjct: 427 YDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCS-DKVQSYDPETNSW 482
Score = 53.1 bits (126), Expect = 8e-07
Identities = 33/123 (26%), Positives = 56/123 (45%), Gaps = 11/123 (8%)
Query: 356 SKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFD 415
S +++ YD + + W A + + + N +YV GG + ++ +D
Sbjct: 469 SDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTK----------AIYCYD 518
Query: 416 PRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELP-TVECYNPRTNEWTYVAKM 474
P + WM V + ++ +S G +Y +GGR GE T+ CY+P T+ T VA M
Sbjct: 519 PVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAM 578
Query: 475 SEP 477
P
Sbjct: 579 PRP 581
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 218 bits (554), Expect = 2e-56
Identities = 156/561 (27%), Positives = 269/561 (47%), Gaps = 29/561 (5%)
Query: 76 SVVLQ-GFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMC 134
S++LQ G + LR+E L DV L + F HRV++A+AS+YF+AMF +KE+
Sbjct: 55 SLILQNGLETLRMENALTDVILCVDIQE--FSCHRVVLAAASNYFRAMFCNDLKEKYEKR 112
Query: 135 IKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLD 194
I + GV + ++D+ YT+K + N+Q LEAA+ Q L ++D C FL + +
Sbjct: 113 IIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPE 172
Query: 195 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTE 254
NCV + R+A+T++L + K V S++++NF +L++ EFL LP + L +L S+ L E
Sbjct: 173 NCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEE 232
Query: 255 LELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLL 313
++F+ W+R + R+ +++N+R PL+ P + V+ +R LL
Sbjct: 233 AQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQ 292
Query: 314 EASNYQMMPYMQPVMQSDRTAIRS---DTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWK 370
EA Y + + S+RT R + + +GG + + V+ E+ D
Sbjct: 293 EARMYHL---SGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVA-EVTCLDPLRRSRL 348
Query: 371 SLAPMDAPRYQHGIAVIG----NFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVAS 426
+A + P +H + F V Y + GK V++++ NKW+Q+
Sbjct: 349 EVAKL--PLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEY 406
Query: 427 LNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVY 486
LN R + L G +Y +GG + + VE Y+P N W+ A + A T +
Sbjct: 407 LNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSH 466
Query: 487 GGVMYISGGITHDTFQKE-LMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHF 545
+Y+ GG + + C+DP T+KW KA M + +R+YV+GG
Sbjct: 467 KKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG--- 523
Query: 546 RGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEI 605
+ + YSP+ D W + + ++ G+A N++Y+ GG N ++
Sbjct: 524 -------AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNE-VIAT 575
Query: 606 VQKYDPDKDEWHKVFDLPESL 626
V +DP+ + + LP +
Sbjct: 576 VLCWDPEAQKLTEECVLPRGV 596
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,305,294
Number of Sequences: 37866
Number of extensions: 1120311
Number of successful extensions: 4019
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 141
Number of HSP's successfully gapped in prelim test: 63
Number of HSP's that attempted gapping in prelim test: 2392
Number of HSP's gapped (non-prelim): 446
length of query: 655
length of database: 18,247,518
effective HSP length: 109
effective length of query: 546
effective length of database: 14,120,124
effective search space: 7709587704
effective search space used: 7709587704
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.