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Search of human proteins with 45593142
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45593142 kelch repeat and BTB (POZ) domain containing 5
[Homo sapiens]
(621 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45593142 kelch repeat and BTB (POZ) domain containing 5 [Homo... 1245 0.0
gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Hom... 663 0.0
gi|40807500 kelch-like 20 [Homo sapiens] 189 7e-48
gi|38194229 kelch-like 17 [Homo sapiens] 189 9e-48
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 183 5e-46
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 182 6e-46
gi|40018614 DRE1 protein [Homo sapiens] 177 2e-44
gi|11056006 kelch-like 12 [Homo sapiens] 176 7e-44
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 172 1e-42
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 172 1e-42
gi|55925604 kelch-like 18 [Homo sapiens] 171 2e-42
gi|109150407 kelch-like 6 [Homo sapiens] 168 1e-41
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 165 1e-40
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 165 1e-40
gi|148664248 kelch domain containing 6 [Homo sapiens] 164 3e-40
gi|148664209 kelch-like 10 [Homo sapiens] 162 1e-39
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 161 2e-39
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 160 2e-39
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 160 2e-39
gi|34101268 kelch-like 8 [Homo sapiens] 158 1e-38
gi|14780904 kelch-like 1 protein [Homo sapiens] 157 3e-38
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 157 4e-38
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 154 2e-37
gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Hom... 154 3e-37
gi|223890235 intracisternal A particle-promoted polypeptide isof... 152 9e-37
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 150 3e-36
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 150 3e-36
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 150 3e-36
gi|128485503 kelch-like 30 [Homo sapiens] 150 4e-36
gi|55925608 kelch-like 21 [Homo sapiens] 148 1e-35
>gi|45593142 kelch repeat and BTB (POZ) domain containing 5 [Homo
sapiens]
Length = 621
Score = 1245 bits (3221), Expect = 0.0
Identities = 621/621 (100%), Positives = 621/621 (100%)
Query: 1 MALGLEQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRA 60
MALGLEQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRA
Sbjct: 1 MALGLEQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRA 60
Query: 61 RFLAEPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTIC 120
RFLAEPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTIC
Sbjct: 61 RFLAEPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTIC 120
Query: 121 VSFLQKRLCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAI 180
VSFLQKRLCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAI
Sbjct: 121 VSFLQKRLCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAI 180
Query: 181 ISSDGLNVEKEEAVFEAVMRWAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVER 240
ISSDGLNVEKEEAVFEAVMRWAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVER
Sbjct: 181 ISSDGLNVEKEEAVFEAVMRWAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVER 240
Query: 241 HPLVRAQPELLRKVQMVKDAHEGRITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAER 300
HPLVRAQPELLRKVQMVKDAHEGRITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAER
Sbjct: 241 HPLVRAQPELLRKVQMVKDAHEGRITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAER 300
Query: 301 ILPGILNDTLRFGMFLQDLIFMISEEGAVAYDPAANECYCASLSNQVPKNHVSLVTKENQ 360
ILPGILNDTLRFGMFLQDLIFMISEEGAVAYDPAANECYCASLSNQVPKNHVSLVTKENQ
Sbjct: 301 ILPGILNDTLRFGMFLQDLIFMISEEGAVAYDPAANECYCASLSNQVPKNHVSLVTKENQ 360
Query: 361 VFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGR 420
VFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGR
Sbjct: 361 VFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGR 420
Query: 421 EIKDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKM 480
EIKDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKM
Sbjct: 421 EIKDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKM 480
Query: 481 CVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPF 540
CVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPF
Sbjct: 481 CVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPF 540
Query: 541 EAFPQERSSLSLVSLVGTLYAIGGFATLETESGELVPTELNDIWRYNEEEKKWEGVLREI 600
EAFPQERSSLSLVSLVGTLYAIGGFATLETESGELVPTELNDIWRYNEEEKKWEGVLREI
Sbjct: 541 EAFPQERSSLSLVSLVGTLYAIGGFATLETESGELVPTELNDIWRYNEEEKKWEGVLREI 600
Query: 601 AYAAGATFLPVRLNVLCLTKM 621
AYAAGATFLPVRLNVLCLTKM
Sbjct: 601 AYAAGATFLPVRLNVLCLTKM 621
>gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Homo
sapiens]
Length = 606
Score = 663 bits (1710), Expect = 0.0
Identities = 313/618 (50%), Positives = 444/618 (71%), Gaps = 19/618 (3%)
Query: 6 EQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAE 65
E AEE RLYQ TLLQDGLKD+LD KF+DC ++AG++ PCHRL+L+ACSPYFR FL+E
Sbjct: 6 ELAEELRLYQSTLLQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSE 65
Query: 66 PERAG--ELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSF 123
+ A E+ L+ V P ++ ++ YLY++ I L++ +VQD+FA A RFQIPS+FT+CVS+
Sbjct: 66 IDEAKKKEVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSY 125
Query: 124 LQKRLCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISS 183
LQKRL NCLA+ RLGLLLDC RLA++AR+F+ F + ++ DF+ LS ELI++IS+
Sbjct: 126 LQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISN 185
Query: 184 DGLNVEKEEAVFEAVMRWAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPL 243
D LNVEKEEAVFEAVM+W + + R + L VF+ +R RL+ + + VE+ +
Sbjct: 186 DSLNVEKEEAVFEAVMKWVRTD----KENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDI 241
Query: 244 VRAQPELLRKVQMVKDAHEGRITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILP 303
+++ P+L +K++++KDA G++ K K GAG D G E +LP
Sbjct: 242 IKSNPDLQKKIKVLKDAFAGKLPE-PSKNAAKTGAGEVNGDVGD-----------EDLLP 289
Query: 304 GILNDTLRFGMFLQDLIFMISEEGAVAYDPAANECYCASLSNQVPKNHVSLVTKENQVFV 363
G LND R GMF++DLI ++++ AVAYDP NECY +L+ Q+P+NH S+VT++NQ++V
Sbjct: 290 GYLNDIPRHGMFVKDLILLVNDTAAVAYDPTENECYLTALAEQIPRNHSSIVTQQNQIYV 349
Query: 364 AGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIK 423
GGL+ +E+NK+ P+ +YF Q D + SEW+G+PPLPS RCLFGLGE + IYVV G++++
Sbjct: 350 VGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQ 409
Query: 424 DGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVY 483
E LDSV+CYD ++ KW E LP VYGH V+SH ++Y +GGK D+KC N++ ++
Sbjct: 410 T-EASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIF 468
Query: 484 DPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAF 543
+PKK +WK+LAPM+ RS+FG VH G+I++A GVT+ GL++S E + +T NKW F
Sbjct: 469 NPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEF 528
Query: 544 PQERSSLSLVSLVGTLYAIGGFATLETESGELVPTELNDIWRYNEEEKKWEGVLREIAYA 603
PQERSS+SLVSL G+LYAIGGFA ++ ES E PTE+NDIW+Y +++K+W G+L+EI YA
Sbjct: 529 PQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYA 588
Query: 604 AGATFLPVRLNVLCLTKM 621
+GA+ L RLN+ L+K+
Sbjct: 589 SGASCLATRLNLFKLSKL 606
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 189 bits (480), Expect = 7e-48
Identities = 160/546 (29%), Positives = 239/546 (43%), Gaps = 56/546 (10%)
Query: 29 HGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAE--PERAGELHLEEVSPDVVAQVL 86
H + D V+ G ++ HR++L+ACSPYFRA F E R E+ + ++ + ++
Sbjct: 64 HRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLI 123
Query: 87 HYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDCA 146
+ YTS+I ++E +VQ L AA Q+ I C FL+++L SNCL + C
Sbjct: 124 DFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCR 183
Query: 147 RLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGD 206
L A F +F V +F+ L A++LI IISSD LNV EE VF AVM W
Sbjct: 184 ELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWV---- 239
Query: 207 AEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDAHEGRIT 266
+ ER+ LP V + VR LL FL V PL+++ E V K+
Sbjct: 240 KYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKN-----YL 294
Query: 267 TLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLIFMISEE 326
L +++ G + + + +L + G D I +
Sbjct: 295 LLPQERPLMQG----------PRTRPRKPIRCGEVLFAV------GGWCSGDAISSVER- 337
Query: 327 GAVAYDPAANEC-YCASLSNQVPKNHVSLVTKENQVFVAGG----LFYNEDNKEDPMSAY 381
YDP NE AS+S + + V + ++ ++ GG + N + DP +
Sbjct: 338 ----YDPQTNEWRMVASMSKR--RCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKT-- 389
Query: 382 FLQFDHLDSEWLGMPPLPSPRCLFGLGEAL--NSIYVVGGREIKDGERCLDSVMCYDRLS 439
++W P+ C +G A+ +Y VGG +DG CL+ V YD
Sbjct: 390 --------NQW-SSDVAPTSTCRTSVGVAVLGGFLYAVGG---QDGVSCLNIVERYDPKE 437
Query: 440 FKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTA 499
KW + G V +Y +GG LN + Y+P++ W +APM T
Sbjct: 438 NKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSP-LNTVERYNPQENRWHTIAPMGTR 496
Query: 500 RSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTL 559
R G V+ I G DT SSAE Y+ N+W+P A RS + L + G L
Sbjct: 497 RKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQL 556
Query: 560 YAIGGF 565
A+GGF
Sbjct: 557 MAVGGF 562
Score = 75.5 bits (184), Expect = 1e-13
Identities = 62/226 (27%), Positives = 93/226 (41%), Gaps = 20/226 (8%)
Query: 384 QFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWG 443
++D +EW + + RC G+ + +Y VGG DG L+SV YD + +W
Sbjct: 337 RYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGH---DGSSYLNSVERYDPKTNQW- 392
Query: 444 ESDPLP----YVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTA 499
SD P G VL +Y +GG+ CLN + YDPK+ +W +A M T
Sbjct: 393 SSDVAPTSTCRTSVGVAVLG--GFLYAVGGQ-DGVSCLNIVERYDPKENKWTRVASMSTR 449
Query: 500 RSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTL 559
R V G + G T ++ E Y+ +N+W R L +
Sbjct: 450 RLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMI 509
Query: 560 YAIGGFATLETESGELVPTELNDIWRYNEEEKKWEGVLREIAYAAG 605
YA+GG TEL+ RYN +W V+ + +G
Sbjct: 510 YAVGGRDD---------TTELSSAERYNPRTNQWSPVVAMTSRRSG 546
Score = 35.8 bits (81), Expect = 0.12
Identities = 41/179 (22%), Positives = 73/179 (40%), Gaps = 18/179 (10%)
Query: 422 IKDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSD------RK 475
++ E+ ++VM + + S + E P V H L + +++G GSD +
Sbjct: 225 VRSEEQVFNAVMAWVKYSIQ--ERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEE 282
Query: 476 CLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTG-LTSSAEVYSITD 534
C + + +E MQ R+ + G ++ A G +G SS E Y
Sbjct: 283 CRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQT 342
Query: 535 NKWAPFEAFPQERSSLSLVSLVGTLYAIGGFATLETESGELVPTELNDIWRYNEEEKKW 593
N+W + + R + + L LYA+GG G + LN + RY+ + +W
Sbjct: 343 NEWRMVASMSKRRCGVGVSVLDDLLYAVGG------HDGS---SYLNSVERYDPKTNQW 392
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 189 bits (479), Expect = 9e-48
Identities = 161/571 (28%), Positives = 248/571 (43%), Gaps = 54/571 (9%)
Query: 26 MLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELH--LEEVSPDVVA 83
M G D V+ +E H++VLA+CSPYF A F E + + H L ++ P +
Sbjct: 85 MRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALD 144
Query: 84 QVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLL 143
Q++ + YT+EI + E +VQ L AA Q+ + C FL +L SNCL +
Sbjct: 145 QLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADAH 204
Query: 144 DCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAG 203
C+ L AA ++ HF VA+ +F+ L +++ ++SSD LNV EE V+ AV+ W
Sbjct: 205 SCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLSWV- 263
Query: 204 SGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDAHEG 263
D +A R++ +P + + VR LL R FL V+ LVR P+ + H
Sbjct: 264 KHDVDA---RRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFH-- 318
Query: 264 RITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLIFMI 323
L +++G GTS+ + E A +L + +L F I
Sbjct: 319 ----LLPEQRGV---------LGTSRTRPRRCEGAGPVLFAVGGGSL----------FAI 355
Query: 324 SEEGAVAYDPAANECY-CASLSNQVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYF 382
+ AYD + + AS+S + + V + N+++ GG D A
Sbjct: 356 HGD-CEAYDTRTDRWHVVASMSTR--RARVGVAAVGNRLYAVGGYDGTSD------LATV 406
Query: 383 LQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKW 442
+D + + W + + R G+ +Y GG DG CL+S YD L+ W
Sbjct: 407 ESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGG---YDGASCLNSAERYDPLTGTW 463
Query: 443 GESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSL 502
+ V + +Y +GG S L + Y+P+ W +A M + RS
Sbjct: 464 TSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSH-LATVEKYEPQVNVWSPVASMLSRRSS 522
Query: 503 FGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAI 562
G V +G + VA G T +S E YS W RS+ LV++ G LYA+
Sbjct: 523 AGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAV 582
Query: 563 GGFATLETESGELVPTELNDIWRYNEEEKKW 593
GG G + LN I +YN KW
Sbjct: 583 GG------NDGS---SSLNSIEKYNPRTNKW 604
Score = 69.3 bits (168), Expect = 1e-11
Identities = 57/212 (26%), Positives = 81/212 (38%), Gaps = 13/212 (6%)
Query: 385 FDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWGE 444
+D W + + + R G+ N +Y VGG DG L +V YD ++ W
Sbjct: 362 YDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGY---DGTSDLATVESYDPVTNTWQP 418
Query: 445 SDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFG 504
+ V + L+Y GG CLN YDP W +A M T R
Sbjct: 419 EVSMGTRRSCLGVAALHGLLYSAGGYDG-ASCLNSAERYDPLTGTWTSVAAMSTRRRYVR 477
Query: 505 ATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGG 564
DG + G + ++ E Y N W+P + RSS + L G LY GG
Sbjct: 478 VATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGG 537
Query: 565 FATLETESGELVPTELNDIWRYNEEEKKWEGV 596
G + LN + RY+ + WE V
Sbjct: 538 ------NDG---TSCLNSVERYSPKAGAWESV 560
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 183 bits (464), Expect = 5e-46
Identities = 145/576 (25%), Positives = 237/576 (41%), Gaps = 59/576 (10%)
Query: 23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAE--PERAGELHLEEVSPD 80
+ +M D ++ ER+ P HR+VLAA S +F F ++ E+ L++ PD
Sbjct: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93
Query: 81 VVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLG 140
++ Q++ + YT+ I+++ +VQ L AA+++QI + +CV FL++++ SNCL + L
Sbjct: 94 IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153
Query: 141 LLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMR 200
LDC L A DFI HFT V + +FL L + +++ D L V E+ V++A +R
Sbjct: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213
Query: 201 WAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDA 260
W + RQ + + VR L+ + FL V+ PL++ PE L+ V
Sbjct: 214 WL----KYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMV------ 263
Query: 261 HEGRITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLI 320
I+ +R + +E GT + + D + +
Sbjct: 264 ----ISGMRYHLLSPE--DREELVDGTRPRRKKHD--------------------YRIAL 297
Query: 321 FMISEEGAVAYDPAANECYCASLSNQVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSA 380
F S+ + Y + + + + V +N V++ GG + D
Sbjct: 298 FGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFPIKRMD---- 353
Query: 381 YFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSF 440
++ + W P+PR A IY GG E+ G L CYD +
Sbjct: 354 ---CYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEV--GNSALYLFECYDTRTE 408
Query: 441 KWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDR---KCLNKMCVYDPKKFEWKELAPMQ 497
W + H ++ L+YV GG + + LN VYDP W EL PM
Sbjct: 409 SWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMI 468
Query: 498 TARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVG 557
AR G +I G G + E Y I N+W P + ++ ++
Sbjct: 469 EARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGS 528
Query: 558 TLYAIGGFATLETESGELVPTELNDIWRYNEEEKKW 593
+Y + GF + L I YN E KW
Sbjct: 529 IVYVLAGFQGV---------GRLGHILEYNTETDKW 555
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 182 bits (463), Expect = 6e-46
Identities = 144/565 (25%), Positives = 234/565 (41%), Gaps = 59/565 (10%)
Query: 34 DCVVRAGEREFPCHRLVLAACSPYFRARFLAE--PERAGELHLEEVSPDVVAQVLHYLYT 91
D ++ ER+ P HR+VLAA S +F F ++ E+ L++ PD++ Q++ + YT
Sbjct: 23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYT 82
Query: 92 SEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDCARLAVA 151
+ I+++ +VQ L AA+++QI + +CV FL++++ SNCL + L LDC L
Sbjct: 83 ARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKAT 142
Query: 152 ARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGDAEAQA 211
A DFI HFT V + +FL L + +++ D L V E+ V++A +RW +
Sbjct: 143 ADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWL----KYDEP 198
Query: 212 ERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDAHEGRITTLRKK 271
RQ + + VR L+ + FL V+ PL++ PE L+ V I+ +R
Sbjct: 199 NRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMV----------ISGMRYH 248
Query: 272 KKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLIFMISEEGAVAY 331
+ +E GT + + D + +F S+ + Y
Sbjct: 249 LLSPE--DREELVDGTRPRRKKHD--------------------YRIALFGGSQPQSCRY 286
Query: 332 DPAANECYCASLSNQVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDSE 391
+ + + + V +N V++ GG + D ++ +
Sbjct: 287 FNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFPIKRMD-------CYNVVKDS 339
Query: 392 WLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWGESDPLPYV 451
W P+PR A IY GG E+ G L CYD + W +
Sbjct: 340 WYSKLGPPTPRDSLAACAAEGKIYTSGGSEV--GNSALYLFECYDTRTESWHTKPSMLTQ 397
Query: 452 VYGHTVLSHMDLVYVIGGKGSDR---KCLNKMCVYDPKKFEWKELAPMQTARSLFGATVH 508
H ++ L+YV GG + + LN VYDP W EL PM AR G
Sbjct: 398 RCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFV 457
Query: 509 DGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGGFATL 568
+I G G + E Y I N+W P + ++ ++ +Y + GF +
Sbjct: 458 KDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGV 517
Query: 569 ETESGELVPTELNDIWRYNEEEKKW 593
L I YN E KW
Sbjct: 518 ---------GRLGHILEYNTETDKW 533
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 177 bits (450), Expect = 2e-44
Identities = 152/555 (27%), Positives = 231/555 (41%), Gaps = 54/555 (9%)
Query: 28 DHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLE--EVSPDVVAQV 85
D F D ++ +EFPCHR VL+ACS YFRA F + + E+ +E + + +
Sbjct: 61 DSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECF 120
Query: 86 LHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDC 145
L Y+YT ++ + +VQ LF + FQI + C FL+++L NCL + R
Sbjct: 121 LQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSL 180
Query: 146 ARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSG 205
L ++F F V++ +FL L DELI I SD L + KEE VFEAVMRW
Sbjct: 181 KTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWV--- 237
Query: 206 DAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDAHEGRI 265
A R+ L + VR LL + VE L++ PE + + + H
Sbjct: 238 -YRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGN 296
Query: 266 TTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLIFMISE 325
+ + + + G E + ++ R G F +
Sbjct: 297 EMMSPRTRPRRSTGYSE-------------------VIVVVGGCERVGGF--------NL 329
Query: 326 EGAVAYDPAANECYCASLSNQVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQF 385
YDP E + + K+ ++ N + V+GG + D + Y Q
Sbjct: 330 PYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRD-----VWIYNSQL 384
Query: 386 DHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWGES 445
+ W+ + L R + L +YVVGG DG+ L SV CYD S +W E
Sbjct: 385 ----NIWIRVASLNKGRWRHKMAVLLGKVYVVGG---YDGQNRLSSVECYDSFSNRWTEV 437
Query: 446 DPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGA 505
PL V V S + ++VIGG D C +K+ YDP+ W A + A+ A
Sbjct: 438 APLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITA 497
Query: 506 TVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGGF 565
+ I VA GLT + Y ++ W + + + + G +Y +GG
Sbjct: 498 VSLNNLIYVAG-----GLTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGG- 551
Query: 566 ATLETESGELVPTEL 580
E+GE T L
Sbjct: 552 ---RRENGEATDTIL 563
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 176 bits (445), Expect = 7e-44
Identities = 146/535 (27%), Positives = 236/535 (44%), Gaps = 43/535 (8%)
Query: 34 DCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGE--LHLEEVSPDVVAQVLHYLYT 91
D +R +++FP HR+VLAACS YF A F +E G+ + ++ ++ + +L ++YT
Sbjct: 34 DVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTASTMEILLDFVYT 93
Query: 92 SEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDCARLAVA 151
+ + +VQ+L AA Q+ + C FL+ +L SNCL + +C L A
Sbjct: 94 ETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQA 153
Query: 152 ARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGDAEAQA 211
A F HF V + +F+ LS E+ +I D + V+ EE VFEAV+ W A+
Sbjct: 154 AEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVINWV----KHAKK 209
Query: 212 ERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDAHEGRITTLRKK 271
ER+ +LP + + VR LL ++ ++ P +R + V K H LR +
Sbjct: 210 EREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFH------LRPE 263
Query: 272 KKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLIFMISEEGAVAY 331
+ + A G + E ++ G FG Q I ++ + Y
Sbjct: 264 LRSQMQGPRTRARLGAN--------EVLLVVGG-------FGS-QQSPIDVVEK-----Y 302
Query: 332 DPAANE-CYCASLSNQVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDS 390
DP E + S++ + + +V+ V+ ++++V GG Y+ ++ + D D
Sbjct: 303 DPKTQEWSFLPSITRK--RRYVASVSLHDRIYVIGG--YDGRSRLSSVECLDYTADE-DG 357
Query: 391 EWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWGESDPLPY 450
W + P+ R L G + IYV GG DG R S+ YD +W +
Sbjct: 358 VWYSVAPMNVRRGLAGATTLGDMIYVSGG---FDGSRRHTSMERYDPNIDQWSMLGDMQT 414
Query: 451 VVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDG 510
G ++ ++Y +GG LN + YDP W + PM T RS G + +
Sbjct: 415 AREGAGLVVASGVIYCLGGY-DGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLND 473
Query: 511 RIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGGF 565
I V G T SS E Y+I + W + R + L G LYAI G+
Sbjct: 474 HIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGY 528
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 172 bits (435), Expect = 1e-42
Identities = 158/583 (27%), Positives = 237/583 (40%), Gaps = 70/583 (12%)
Query: 23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAE--PERAGELHLEEVSPD 80
+ ++ D + A + E HR+VLAACSPYF A F E RA + ++EV
Sbjct: 50 MNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGW 109
Query: 81 VVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLG 140
+ ++ Y+YT+EI + E +VQ L AA Q+ + C FL+ +L NCL +
Sbjct: 110 TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFA 169
Query: 141 LLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMR 200
+ C L A + HF V +FL L +++ ++ISSD L + EE VFEAV+
Sbjct: 170 DMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIA 229
Query: 201 WAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDA 260
W + RQ + + E VR LLPR +L RVE LV
Sbjct: 230 WVN----HDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALV---------------- 269
Query: 261 HEGRITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLI 320
K+ + K+ K E +RIL + LR M L L+
Sbjct: 270 --------------KNSSACKDYLIEAMKYHLLPTE--QRILMKSVRTRLRTPMNLPKLM 313
Query: 321 FMISEEGAVAYDPAANECY---------CASLSNQVPKNHVSLVTKENQVFVAGGLFYNE 371
++ + A + ECY A L ++ + +V VF GG +N
Sbjct: 314 VVVGGQAPKAI--RSVECYDFKEERWHQVAELPSR--RCRAGMVYMAGLVFAVGG--FNG 367
Query: 372 DNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDS 431
+ + +Y D + +W + + R G +Y VGG DG L S
Sbjct: 368 SLRVRTVDSY----DPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGG---FDGSTGLSS 420
Query: 432 VMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGG-KGSDRKCLNKMCVYDPKKFEW 490
V Y+ S +W P+ V L+Y +GG G+ R+CL+ + Y+ EW
Sbjct: 421 VEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEW 480
Query: 491 KELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSL 550
+A M T RS G V + + G + S EVY T N W R +
Sbjct: 481 TYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNA 540
Query: 551 SLVSLVGTLYAIGGFATLETESGELVPTELNDIWRYNEEEKKW 593
+ ++ G LY +GG + G L + YN KW
Sbjct: 541 GVCAVNGLLYVVGG------DDGS---CNLASVEYYNPTTDKW 574
Score = 73.6 bits (179), Expect = 5e-13
Identities = 60/205 (29%), Positives = 88/205 (42%), Gaps = 28/205 (13%)
Query: 416 VVGGREIKDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGG-KGSDR 474
VVGG+ K + SV CYD +W + LP ++ LV+ +GG GS R
Sbjct: 315 VVGGQAPK----AIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLR 370
Query: 475 KCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITD 534
+ + YDP K +W +A M+ RS GA V +G + G + SS E Y+I
Sbjct: 371 --VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKS 428
Query: 535 NKWAPFEAFPQERSSLSLVSLVGTLYAIGGFATLETESGELVPTELNDIWRYNEEEKKWE 594
N+W RSS+ + + G LYA+GG+ + L+ + YN +W
Sbjct: 429 NEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQC-------LSTVECYNATTNEWT 481
Query: 595 --------------GVLREIAYAAG 605
GVL + YA G
Sbjct: 482 YIAEMSTRRSGAGVGVLNNLLYAVG 506
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 172 bits (435), Expect = 1e-42
Identities = 158/583 (27%), Positives = 237/583 (40%), Gaps = 70/583 (12%)
Query: 23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAE--PERAGELHLEEVSPD 80
+ ++ D + A + E HR+VLAACSPYF A F E RA + ++EV
Sbjct: 46 MNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGW 105
Query: 81 VVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLG 140
+ ++ Y+YT+EI + E +VQ L AA Q+ + C FL+ +L NCL +
Sbjct: 106 TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFA 165
Query: 141 LLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMR 200
+ C L A + HF V +FL L +++ ++ISSD L + EE VFEAV+
Sbjct: 166 DMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIA 225
Query: 201 WAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDA 260
W + RQ + + E VR LLPR +L RVE LV
Sbjct: 226 WVN----HDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALV---------------- 265
Query: 261 HEGRITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLI 320
K+ + K+ K E +RIL + LR M L L+
Sbjct: 266 --------------KNSSACKDYLIEAMKYHLLPTE--QRILMKSVRTRLRTPMNLPKLM 309
Query: 321 FMISEEGAVAYDPAANECY---------CASLSNQVPKNHVSLVTKENQVFVAGGLFYNE 371
++ + A + ECY A L ++ + +V VF GG +N
Sbjct: 310 VVVGGQAPKAI--RSVECYDFKEERWHQVAELPSR--RCRAGMVYMAGLVFAVGG--FNG 363
Query: 372 DNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDS 431
+ + +Y D + +W + + R G +Y VGG DG L S
Sbjct: 364 SLRVRTVDSY----DPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGG---FDGSTGLSS 416
Query: 432 VMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGG-KGSDRKCLNKMCVYDPKKFEW 490
V Y+ S +W P+ V L+Y +GG G+ R+CL+ + Y+ EW
Sbjct: 417 VEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEW 476
Query: 491 KELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSL 550
+A M T RS G V + + G + S EVY T N W R +
Sbjct: 477 TYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNA 536
Query: 551 SLVSLVGTLYAIGGFATLETESGELVPTELNDIWRYNEEEKKW 593
+ ++ G LY +GG + G L + YN KW
Sbjct: 537 GVCAVNGLLYVVGG------DDGS---CNLASVEYYNPTTDKW 570
Score = 73.6 bits (179), Expect = 5e-13
Identities = 60/205 (29%), Positives = 88/205 (42%), Gaps = 28/205 (13%)
Query: 416 VVGGREIKDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGG-KGSDR 474
VVGG+ K + SV CYD +W + LP ++ LV+ +GG GS R
Sbjct: 311 VVGGQAPK----AIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLR 366
Query: 475 KCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITD 534
+ + YDP K +W +A M+ RS GA V +G + G + SS E Y+I
Sbjct: 367 --VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKS 424
Query: 535 NKWAPFEAFPQERSSLSLVSLVGTLYAIGGFATLETESGELVPTELNDIWRYNEEEKKWE 594
N+W RSS+ + + G LYA+GG+ + L+ + YN +W
Sbjct: 425 NEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQC-------LSTVECYNATTNEWT 477
Query: 595 --------------GVLREIAYAAG 605
GVL + YA G
Sbjct: 478 YIAEMSTRRSGAGVGVLNNLLYAVG 502
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 171 bits (433), Expect = 2e-42
Identities = 150/572 (26%), Positives = 235/572 (41%), Gaps = 54/572 (9%)
Query: 23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPE--RAGELHLEEVSPD 80
++++ GK D ++ G+ +F HR+VLAA PYF A F + + E+ ++ + P
Sbjct: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
Query: 81 VVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLG 140
+ ++++ Y +A+D+ +VQ L A Q+ SI C +FL++RL NCL V +
Sbjct: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
Query: 141 LLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMR 200
+ CA L AA FI HF V+ +FL L ++++ ++S D LNV+ EE VFEA +
Sbjct: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALA 207
Query: 201 WAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDA 260
W + +R LP + ++R L FL RV++ LVR + V KD
Sbjct: 208 WV----RYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDY 263
Query: 261 H-----EGRITTLRKKKKGKDG-AGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGM 314
H + R + + AG A G + A D+L
Sbjct: 264 HLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSA----------------GDSLNV-- 305
Query: 315 FLQDLIFMISEEGAVAYDPAANECYCASLSNQVPKNHVSLVTKENQVFVAGGLFYNEDNK 374
+DP AN C+ ++ V + ++ GG Y+ +
Sbjct: 306 -------------VEVFDPIAN-CWERCRPMTTARSRVGVAVVNGLLYAIGG--YDGQLR 349
Query: 375 EDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMC 434
+ AY + D W + + S R G IYV GG DG L SV
Sbjct: 350 LSTVEAYNPETD----TWTRVGSMNSKRSAMGTVVLDGQIYVCGG---YDGNSSLSSVET 402
Query: 435 YDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELA 494
Y + KW + V +YV GG + + + Y+ W A
Sbjct: 403 YSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGH-DGLQIFSSVEHYNHHTATWHPAA 461
Query: 495 PMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVS 554
M R GA ++ V G +G S AE+YS ++W RS +SLV+
Sbjct: 462 GMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVA 521
Query: 555 LVGTLYAIGGFATLETESGELVPTELNDIWRY 586
G LYA+GG+ S + D W +
Sbjct: 522 SCGRLYAVGGYDGQSNLSSVEMYDPETDCWTF 553
Score = 65.9 bits (159), Expect = 1e-10
Identities = 53/202 (26%), Positives = 78/202 (38%), Gaps = 19/202 (9%)
Query: 396 PPLPS----PRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWGESDPLPYV 451
P LP+ PRC + IY VGG + L+ V +D ++ W P+
Sbjct: 271 PHLPAFRTRPRCCTSIA---GLIYAVGG--LNSAGDSLNVVEVFDPIANCWERCRPMTTA 325
Query: 452 VYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGR 511
V L+Y IGG + L+ + Y+P+ W + M + RS G V DG+
Sbjct: 326 RSRVGVAVVNGLLYAIGGYDGQLR-LSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQ 384
Query: 512 IIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGGFATLETE 571
I V G SS E YS +KW + RS+ + G +Y GG L+
Sbjct: 385 IYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQI- 443
Query: 572 SGELVPTELNDIWRYNEEEKKW 593
+ + YN W
Sbjct: 444 --------FSSVEHYNHHTATW 457
Score = 63.9 bits (154), Expect = 4e-10
Identities = 46/155 (29%), Positives = 68/155 (43%), Gaps = 11/155 (7%)
Query: 463 LVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTG 522
L+Y +GG S LN + V+DP W+ PM TARS G V +G + G
Sbjct: 289 LIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQL 348
Query: 523 LTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGGFATLETESGELVPTELND 582
S+ E Y+ + W + +RS++ V L G +Y GG+ G + L+
Sbjct: 349 RLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGY------DGN---SSLSS 399
Query: 583 IWRYNEEEKKWEGV--LREIAYAAGATFLPVRLNV 615
+ Y+ E KW V + AAG T R+ V
Sbjct: 400 VETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYV 434
Score = 35.8 bits (81), Expect = 0.12
Identities = 35/147 (23%), Positives = 60/147 (40%), Gaps = 26/147 (17%)
Query: 358 ENQVFVAGGLFYNEDNKEDPMSAYFL--QFDHLDSEWLGMPPLPSPRCLFGLGEALNSIY 415
E +++V+GG D + + ++H + W + + RC G + ++
Sbjct: 429 EGRIYVSGG--------HDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMF 480
Query: 416 VVGGREIKDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLV------YVIGG 469
V GG DG L Y ++ +W P+ HT S + LV Y +GG
Sbjct: 481 VCGGY---DGSGFLSIAEMYSSVADQWCLIVPM------HTRRSRVSLVASCGRLYAVGG 531
Query: 470 KGSDRKCLNKMCVYDPKKFEWKELAPM 496
L+ + +YDP+ W +APM
Sbjct: 532 YDGQSN-LSSVEMYDPETDCWTFMAPM 557
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 168 bits (426), Expect = 1e-41
Identities = 154/566 (27%), Positives = 236/566 (41%), Gaps = 48/566 (8%)
Query: 18 LLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGE--LHLE 75
+LQ+GL+ + D ++ +EF CHR+VLAA S YFRA F + + E + ++
Sbjct: 57 ILQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIK 116
Query: 76 EVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLA 135
V + + +L Y YTS+ + + +VQ + AA+ FQ + C SFL + L NC+
Sbjct: 117 GVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVG 176
Query: 136 VFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVF 195
+ RL L + +I +F + +FL L D L I+ SD L V +E VF
Sbjct: 177 ILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVF 236
Query: 196 EAVMRWAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQ 255
E VM W +ER LP V E+VR LL + VE PL+R PE+ +Q
Sbjct: 237 ETVMSWV----RHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQ 292
Query: 256 MVKDAHEGRITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMF 315
+ H +G + + T E E I+ G D RF
Sbjct: 293 EARMYHL---------------SGNEIISERTKPRMHEFQSEVFMIIGGCTKDE-RFVAE 336
Query: 316 LQDLIFMISEEGAVAYDPAANECYCASLSNQVPK-NHVSLVTKENQVFVAGGLFYNEDNK 374
+ L + VA P L ++ K + VT +N+V+++GG K
Sbjct: 337 VTCLDPLRRSRLEVAKLPLTEH----ELESENKKWVEFACVTLKNEVYISGG-------K 385
Query: 375 EDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMC 434
E + +++ ++W+ + L R + +YV+GG DG + +++V
Sbjct: 386 ETQHDVW--KYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGG---FDGLQRINNVET 440
Query: 435 YDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELA 494
YD W E+ PL V SH +YVIGG + + +K YDP +W A
Sbjct: 441 YDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKA 500
Query: 495 PMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVS 554
M A RI V G + YS ++ W ER+S +
Sbjct: 501 AMPVEAKCINAVSFRDRIYVVGGA-----MRALYAYSPLEDSWCLVTQLSHERASCGIAP 555
Query: 555 LVGTLYAIGGFATLETESGELVPTEL 580
LY GG E E++ T L
Sbjct: 556 CNNRLYITGG----RDEKNEVIATVL 577
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 165 bits (418), Expect = 1e-40
Identities = 146/554 (26%), Positives = 242/554 (43%), Gaps = 53/554 (9%)
Query: 15 QQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAG--EL 72
+QTL + +++ L + D ++ AG P HRLVL+A S YF A F + A E+
Sbjct: 166 EQTLRK--MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
Query: 73 HLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSN 132
+E V P+ + ++ Y YT + L E +++ L AAA Q+ + +C +FL K+L SN
Sbjct: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
Query: 133 CLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEE 192
CL + G C L A + HF V ++ +FL L A+E+ ++ SD +NV EE
Sbjct: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
Query: 193 AVFEAVMRWAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLR 252
+F A+M+W G D + RQ L + +R LLP L + +E + E +
Sbjct: 344 TIFHALMQWVGH-DVQ---NRQGELGMLLSYIRLPLLPPQLL-ADLETSSMFTGDLECQK 398
Query: 253 ------KVQMVKDAHEGRITTLRKKKKGKDGA----GAKEADKGTSKAKAEEDEEAERIL 302
K ++ + + K +K GA G +A KGT+ + + +
Sbjct: 399 LLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLH 458
Query: 303 PGILND-TLRFGMFLQD--LIFMISEEGAVAYDPAANECY--CASLSNQVP-----KNHV 352
G +N L+FG+ + D L + +G + EC+ + +P ++ +
Sbjct: 459 IGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTV--ECFNPVGKIWTVMPPMSTHRHGL 516
Query: 353 SLVTKENQVFVAGG----LFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLG 408
+ T E ++ GG + N + DP +W + + +PR G+
Sbjct: 517 GVATLEGPMYAVGGHDGWSYLNTVERWDPEG----------RQWNYVASMSTPRSTVGVV 566
Query: 409 EALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIG 468
N +Y +GGR DG CL S+ +D + KW P+ G V ++ +YV+G
Sbjct: 567 ALNNKLYAIGGR---DGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVG 623
Query: 469 G---KGSDRKCLNKMCV--YDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGL 523
G S+ CV YDPK W +AP+ R ++ V G
Sbjct: 624 GHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTY 683
Query: 524 TSSAEVYSITDNKW 537
++ E Y N+W
Sbjct: 684 LNTVESYDAQRNEW 697
Score = 75.5 bits (184), Expect = 1e-13
Identities = 48/181 (26%), Positives = 82/181 (45%), Gaps = 4/181 (2%)
Query: 384 QFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWG 443
++D + WL + + R FG+ N +YVVGGR DG + L++V C++ + W
Sbjct: 448 KYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGR---DGLKTLNTVECFNPVGKIWT 504
Query: 444 ESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLF 503
P+ +G V + +Y +GG LN + +DP+ +W +A M T RS
Sbjct: 505 VMPPMSTHRHGLGVATLEGPMYAVGGHDG-WSYLNTVERWDPEGRQWNYVASMSTPRSTV 563
Query: 504 GATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIG 563
G + ++ G + S E + NKW+ + R + + + G LY +G
Sbjct: 564 GVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVG 623
Query: 564 G 564
G
Sbjct: 624 G 624
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 165 bits (418), Expect = 1e-40
Identities = 146/554 (26%), Positives = 242/554 (43%), Gaps = 53/554 (9%)
Query: 15 QQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAG--EL 72
+QTL + +++ L + D ++ AG P HRLVL+A S YF A F + A E+
Sbjct: 166 EQTLRK--MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
Query: 73 HLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSN 132
+E V P+ + ++ Y YT + L E +++ L AAA Q+ + +C +FL K+L SN
Sbjct: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
Query: 133 CLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEE 192
CL + G C L A + HF V ++ +FL L A+E+ ++ SD +NV EE
Sbjct: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
Query: 193 AVFEAVMRWAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLR 252
+F A+M+W G D + RQ L + +R LLP L + +E + E +
Sbjct: 344 TIFHALMQWVGH-DVQ---NRQGELGMLLSYIRLPLLPPQLL-ADLETSSMFTGDLECQK 398
Query: 253 ------KVQMVKDAHEGRITTLRKKKKGKDGA----GAKEADKGTSKAKAEEDEEAERIL 302
K ++ + + K +K GA G +A KGT+ + + +
Sbjct: 399 LLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLH 458
Query: 303 PGILND-TLRFGMFLQD--LIFMISEEGAVAYDPAANECY--CASLSNQVP-----KNHV 352
G +N L+FG+ + D L + +G + EC+ + +P ++ +
Sbjct: 459 IGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTV--ECFNPVGKIWTVMPPMSTHRHGL 516
Query: 353 SLVTKENQVFVAGG----LFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLG 408
+ T E ++ GG + N + DP +W + + +PR G+
Sbjct: 517 GVATLEGPMYAVGGHDGWSYLNTVERWDPEG----------RQWNYVASMSTPRSTVGVV 566
Query: 409 EALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIG 468
N +Y +GGR DG CL S+ +D + KW P+ G V ++ +YV+G
Sbjct: 567 ALNNKLYAIGGR---DGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVG 623
Query: 469 G---KGSDRKCLNKMCV--YDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGL 523
G S+ CV YDPK W +AP+ R ++ V G
Sbjct: 624 GHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTY 683
Query: 524 TSSAEVYSITDNKW 537
++ E Y N+W
Sbjct: 684 LNTVESYDAQRNEW 697
Score = 75.5 bits (184), Expect = 1e-13
Identities = 48/181 (26%), Positives = 82/181 (45%), Gaps = 4/181 (2%)
Query: 384 QFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWG 443
++D + WL + + R FG+ N +YVVGGR DG + L++V C++ + W
Sbjct: 448 KYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGR---DGLKTLNTVECFNPVGKIWT 504
Query: 444 ESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLF 503
P+ +G V + +Y +GG LN + +DP+ +W +A M T RS
Sbjct: 505 VMPPMSTHRHGLGVATLEGPMYAVGGHDG-WSYLNTVERWDPEGRQWNYVASMSTPRSTV 563
Query: 504 GATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIG 563
G + ++ G + S E + NKW+ + R + + + G LY +G
Sbjct: 564 GVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVG 623
Query: 564 G 564
G
Sbjct: 624 G 624
Score = 54.3 bits (129), Expect = 3e-07
Identities = 49/175 (28%), Positives = 72/175 (41%), Gaps = 13/175 (7%)
Query: 331 YDPAANEC-YCASLSNQVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLD 389
+DP + Y AS+S P++ V +V N+++ GG D S + FD
Sbjct: 543 WDPEGRQWNYVASMST--PRSTVGVVALNNKLYAIGG----RDGSSCLKSMEY--FDPHT 594
Query: 390 SEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCL---DSVMCYDRLSFKWGESD 446
++W P+ R G+ +YVVGG + C D V YD W
Sbjct: 595 NKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVA 654
Query: 447 PLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARS 501
PL V D +YV+GG LN + YD ++ EWKE P+ R+
Sbjct: 655 PLSVPRDAVAVCPLGDKLYVVGGYDG-HTYLNTVESYDAQRNEWKEEVPVNIGRA 708
>gi|148664248 kelch domain containing 6 [Homo sapiens]
Length = 623
Score = 164 bits (414), Expect = 3e-40
Identities = 140/599 (23%), Positives = 258/599 (43%), Gaps = 86/599 (14%)
Query: 9 EEQRLYQQTL-LQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARF---LA 64
E + YQ +L L + +++M + + +D V+ A +FPCHRLVLAA SPYF+A F L
Sbjct: 6 EGKEKYQHSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLL 65
Query: 65 EPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFL 124
E + E+ L +++ + V+ +L+Y+Y + + ++ A+VQ + AA+ Q+ +F++C ++
Sbjct: 66 ECNQR-EVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Query: 125 QKRLCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSD 184
+ SNCL ++ + L+ ++ ++ HF V+ + L + + + +I SD
Sbjct: 125 MDHMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSD 184
Query: 185 GLNVEKEEAVFEAVMRWAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLV 244
LN+ +EE++ + V+RW + R L + + VR L+ +FL + R+ ++
Sbjct: 185 DLNISREESILDLVLRWVNHN----KELRTVHLVELLKQVRLELVNPSFLRQALRRNTML 240
Query: 245 RAQPELLRKVQMVKDAHEGRITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPG 304
+ V ++++A + T P
Sbjct: 241 LCDADC---VDIIQNAFKAIKT------------------------------------PQ 261
Query: 305 ILNDTLRFGMFLQDLIFMISE-------------EGAVAYDPAANECYCAS---LSNQVP 348
+ LR+GM L+ I + + YDP + + Y S +
Sbjct: 262 QHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSRKTYFISSPKYGEGLG 321
Query: 349 KNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLG 408
+V + N + VAG ++ +++ + ++ +++ R L+ LG
Sbjct: 322 TVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEKLCTAEFRELYALG 381
Query: 409 EALNSIYVVGGR-EIKDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVI 467
N +YV+GG+ +IK+ + V Y W PLP + H V++ + +YVI
Sbjct: 382 SIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVI 441
Query: 468 GG--------KGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVT 519
GG + NK+ YDP + +W APM+ ++ F V + I V G+
Sbjct: 442 GGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGIG 501
Query: 520 DTGLTSS--------AEVYSITDNKWAPFEAFPQERSSLSLVS-----LVGTLYAIGGF 565
G E+Y+ + W P SL S + G LY GGF
Sbjct: 502 CVGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGAVDGKLYVCGGF 560
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 162 bits (409), Expect = 1e-39
Identities = 145/563 (25%), Positives = 234/563 (41%), Gaps = 52/563 (9%)
Query: 30 GKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGE--LHLEEVSPDVVAQVLH 87
GK D V++ EF H+ +L +CS YFRA F + + ++ +SPD++ ++
Sbjct: 36 GKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIE 95
Query: 88 YLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDCAR 147
Y YT + + +V+ L AAA +F I I C FL+ LCL NC+ + + C
Sbjct: 96 YAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPE 155
Query: 148 LAVAARDFICAHF-TLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGD 206
L A FI +F +V A+FL LS EL II D LNV++E+AVFEA+++W S D
Sbjct: 156 LRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWI-SHD 214
Query: 207 AEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDAHEGRIT 266
+ R++ + + VR L+ + + V+ + VKD+ E +
Sbjct: 215 PQ---NRKQHISILLPKVRLALMHAEYFMNNVKMN-------------DYVKDSEECKPV 258
Query: 267 TLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLIFMISEE 326
+ K D G S + R+ IL G + S
Sbjct: 259 IINALKAMYD-----LNMNGPSNSDFTNPLTRPRLPYAIL---FAIGGWSGG-----SPT 305
Query: 327 GAV-AYDPAANECYCASLSNQVPKNHVSLVTKENQVFVAGGL----FYNEDNKEDPMSAY 381
A+ AYD A+ + + P+ + + V++ GG ++N + DP+
Sbjct: 306 NAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVK-- 363
Query: 382 FLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFK 441
W + P+ S RC + N IY +GG DG L++ Y+ + +
Sbjct: 364 --------KTWHQVAPMHSRRCYVSVTVLGNFIYAMGG---FDGYVRLNTAERYEPETNQ 412
Query: 442 WGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARS 501
W P+ + + VY+ GG + +CL VY+ + +W +APM++ RS
Sbjct: 413 WTLIAPMHEQRSDASATTLYGKVYICGGFNGN-ECLFTAEVYNTESNQWTVIAPMRSRRS 471
Query: 502 LFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYA 561
G + + G SAE YS N W RS+ + + L+
Sbjct: 472 GIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFV 531
Query: 562 IGGFATLETESGELVPTELNDIW 584
+GGF T E D W
Sbjct: 532 VGGFNGFTTTFNVECYDEKTDEW 554
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 161 bits (407), Expect = 2e-39
Identities = 153/552 (27%), Positives = 221/552 (40%), Gaps = 50/552 (9%)
Query: 23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARF---LAEPERAGELHLEEVSP 79
L + H F D + AG+R FPCHR VLAA S YF A F L E + + P
Sbjct: 36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHP 95
Query: 80 DVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRL 139
+V+ +L + Y+S IA++E + + L A Q + FL+K L SNCL + L
Sbjct: 96 EVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLL 155
Query: 140 GLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVM 199
C RL + HF V + DF LS D L+ +ISSD L E E VFEA++
Sbjct: 156 SDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAIL 215
Query: 200 RWAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKD 259
+W D E R+ LP + SVR LLP L+ V L+ A + +++ D
Sbjct: 216 QWV-KHDLE---PRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMAD----ERTKLIMD 267
Query: 260 AHEGRITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDL 319
LR K + G + A+ + IL G F+ D
Sbjct: 268 ------EALRCKTRILQNDGVVT----SPCARPRKAGHTLLILGG--------QTFMCDK 309
Query: 320 IFMISEEGAVAYDPAANECYCASLSNQVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMS 379
I+ + + A P+ S +V+V GG E+ +S
Sbjct: 310 IYQVDHKAKEIIPKA---------DLPSPRKEFSASAIGCKVYVTGG-----RGSENGVS 355
Query: 380 AYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDG------ERCLDSVM 433
+D + EW P+ R G E N +YVVGG G L V
Sbjct: 356 KDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVE 415
Query: 434 CYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKEL 493
YD + KW PL V V+S ++V GG R ++K+ YDP + W
Sbjct: 416 KYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIK 475
Query: 494 APMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLV 553
A A V +I + G T+ +SA + N+W +R S +
Sbjct: 476 AECPQPWRYTAAAVLGSQIFIMGGDTEF-TAASAYRFDCETNQWTRIGDMTAKRMSCHAL 534
Query: 554 SLVGTLYAIGGF 565
+ LY +GG+
Sbjct: 535 ASGNKLYVVGGY 546
Score = 63.5 bits (153), Expect = 5e-10
Identities = 52/218 (23%), Positives = 84/218 (38%), Gaps = 11/218 (5%)
Query: 384 QFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWG 443
Q DH E + LPSPR F +YV GGR ++G V YD + +W
Sbjct: 312 QVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENG--VSKDVWVYDTVHEEWS 369
Query: 444 ESDPLPYVVYGHTVLSHMDLVYVIGG--------KGSDRKCLNKMCVYDPKKFEWKELAP 495
++ P+ +GH + +YV+GG S L ++ YDP +W +AP
Sbjct: 370 KAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAP 429
Query: 496 MQTARSLFGATVHDGRIIVAAGVT-DTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVS 554
++ S ++ V G + + S + Y ++N+W PQ +
Sbjct: 430 LRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAV 489
Query: 555 LVGTLYAIGGFATLETESGELVPTELNDIWRYNEEEKK 592
L ++ +GG S E N R + K
Sbjct: 490 LGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAK 527
Score = 33.1 bits (74), Expect = 0.78
Identities = 31/141 (21%), Positives = 53/141 (37%), Gaps = 11/141 (7%)
Query: 454 GHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRII 513
GHT+L ++GG+ +K+ D K E A + + R F A+ ++
Sbjct: 294 GHTLL-------ILGGQTF---MCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVY 343
Query: 514 VAAGV-TDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGGFATLETES 572
V G ++ G++ VY +W+ R L LY +GG +L
Sbjct: 344 VTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVF 403
Query: 573 GELVPTELNDIWRYNEEEKKW 593
L + +Y+ KW
Sbjct: 404 PASPSVSLKQVEKYDPGANKW 424
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 160 bits (406), Expect = 2e-39
Identities = 139/546 (25%), Positives = 231/546 (42%), Gaps = 51/546 (9%)
Query: 23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAG--ELHLEEVSPD 80
+++ L H + D ++ AG+R P HRLVL++ S YF A F + A E+ +E V P+
Sbjct: 164 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPN 223
Query: 81 VVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLG 140
+ ++ Y YT + L E +++ L + A Q+ + C FL K+L SNCL +
Sbjct: 224 SLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFA 283
Query: 141 LLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMR 200
C L A ++ HF V R+ +F+ L A E+ +++SD +N+ EE + A++
Sbjct: 284 DAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLT 343
Query: 201 WAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDA 260
W D E +R++ L + +R LL FL + +E + L R E + +
Sbjct: 344 WV-RHDLE---QRRKDLSKLLAYIRLPLLAPQFL-ADMENNVLFRDDIECQKLIMEAMKY 398
Query: 261 H---------EGRITTLRKKKKGK-DGAGAKEADKG-TSKAKAEEDEEAERILPGILNDT 309
H + T RK G G ++ KG TS K + + +
Sbjct: 399 HLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRR 458
Query: 310 LRFGM-FLQDLIFMI-SEEGAVAYDPAANECYCASLSN-------QVPKNHVSLVTKENQ 360
L+FG+ L D ++++ +G + ECY ++ + + E
Sbjct: 459 LQFGVAVLDDKLYVVGGRDGLKTLNTV--ECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 516
Query: 361 VFVAGG----LFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYV 416
++ GG + N + DP + +W + + +PR G+ +Y
Sbjct: 517 MYAVGGHDGWSYLNTVERWDPQA----------RQWNFVATMSTPRSTVGVAVLSGKLYA 566
Query: 417 VGGREIKDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKC 476
VGGR DG CL SV C+D + KW + G V + L+Y IGG +
Sbjct: 567 VGGR---DGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASN 623
Query: 477 LNKM---CV--YDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYS 531
L CV YDPK W +A M +R G + ++ G ++ E Y
Sbjct: 624 LTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYD 683
Query: 532 ITDNKW 537
N+W
Sbjct: 684 PQTNEW 689
Score = 80.1 bits (196), Expect = 6e-15
Identities = 56/213 (26%), Positives = 92/213 (43%), Gaps = 7/213 (3%)
Query: 384 QFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWG 443
++D + W + + R FG+ + +YVVGGR DG + L++V CY+ + W
Sbjct: 440 KYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR---DGLKTLNTVECYNPKTKTWS 496
Query: 444 ESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLF 503
P+ +G V +Y +GG LN + +DP+ +W +A M T RS
Sbjct: 497 VMPPMSTHRHGLGVAVLEGPMYAVGGHDG-WSYLNTVERWDPQARQWNFVATMSTPRSTV 555
Query: 504 GATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIG 563
G V G++ G + S E + NKW + R + + + G LYAIG
Sbjct: 556 GVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIG 615
Query: 564 GFATLETESGELVPTELNDIWRYNEEEKKWEGV 596
G + + L + + RY+ + W V
Sbjct: 616 GH---DAPASNLTSRLSDCVERYDPKTDMWTAV 645
Score = 37.0 bits (84), Expect = 0.054
Identities = 23/84 (27%), Positives = 32/84 (38%), Gaps = 9/84 (10%)
Query: 510 GRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGGFATLE 569
G + G+ T +S E Y + N W P R + L LY +GG L+
Sbjct: 421 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 480
Query: 570 TESGELVPTELNDIWRYNEEEKKW 593
T LN + YN + K W
Sbjct: 481 T---------LNTVECYNPKTKTW 495
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 160 bits (406), Expect = 2e-39
Identities = 139/546 (25%), Positives = 231/546 (42%), Gaps = 51/546 (9%)
Query: 23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAG--ELHLEEVSPD 80
+++ L H + D ++ AG+R P HRLVL++ S YF A F + A E+ +E V P+
Sbjct: 210 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPN 269
Query: 81 VVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLG 140
+ ++ Y YT + L E +++ L + A Q+ + C FL K+L SNCL +
Sbjct: 270 SLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFA 329
Query: 141 LLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMR 200
C L A ++ HF V R+ +F+ L A E+ +++SD +N+ EE + A++
Sbjct: 330 DAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLT 389
Query: 201 WAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDA 260
W D E +R++ L + +R LL FL + +E + L R E + +
Sbjct: 390 WV-RHDLE---QRRKDLSKLLAYIRLPLLAPQFL-ADMENNVLFRDDIECQKLIMEAMKY 444
Query: 261 H---------EGRITTLRKKKKGK-DGAGAKEADKG-TSKAKAEEDEEAERILPGILNDT 309
H + T RK G G ++ KG TS K + + +
Sbjct: 445 HLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRR 504
Query: 310 LRFGM-FLQDLIFMI-SEEGAVAYDPAANECYCASLSN-------QVPKNHVSLVTKENQ 360
L+FG+ L D ++++ +G + ECY ++ + + E
Sbjct: 505 LQFGVAVLDDKLYVVGGRDGLKTLNTV--ECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 562
Query: 361 VFVAGG----LFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYV 416
++ GG + N + DP + +W + + +PR G+ +Y
Sbjct: 563 MYAVGGHDGWSYLNTVERWDPQA----------RQWNFVATMSTPRSTVGVAVLSGKLYA 612
Query: 417 VGGREIKDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKC 476
VGGR DG CL SV C+D + KW + G V + L+Y IGG +
Sbjct: 613 VGGR---DGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASN 669
Query: 477 LNKM---CV--YDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYS 531
L CV YDPK W +A M +R G + ++ G ++ E Y
Sbjct: 670 LTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYD 729
Query: 532 ITDNKW 537
N+W
Sbjct: 730 PQTNEW 735
Score = 80.1 bits (196), Expect = 6e-15
Identities = 56/213 (26%), Positives = 92/213 (43%), Gaps = 7/213 (3%)
Query: 384 QFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWG 443
++D + W + + R FG+ + +YVVGGR DG + L++V CY+ + W
Sbjct: 486 KYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR---DGLKTLNTVECYNPKTKTWS 542
Query: 444 ESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLF 503
P+ +G V +Y +GG LN + +DP+ +W +A M T RS
Sbjct: 543 VMPPMSTHRHGLGVAVLEGPMYAVGGHDG-WSYLNTVERWDPQARQWNFVATMSTPRSTV 601
Query: 504 GATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIG 563
G V G++ G + S E + NKW + R + + + G LYAIG
Sbjct: 602 GVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIG 661
Query: 564 GFATLETESGELVPTELNDIWRYNEEEKKWEGV 596
G + + L + + RY+ + W V
Sbjct: 662 GH---DAPASNLTSRLSDCVERYDPKTDMWTAV 691
Score = 37.0 bits (84), Expect = 0.054
Identities = 23/84 (27%), Positives = 32/84 (38%), Gaps = 9/84 (10%)
Query: 510 GRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGGFATLE 569
G + G+ T +S E Y + N W P R + L LY +GG L+
Sbjct: 467 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 526
Query: 570 TESGELVPTELNDIWRYNEEEKKW 593
T LN + YN + K W
Sbjct: 527 T---------LNTVECYNPKTKTW 541
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 158 bits (400), Expect = 1e-38
Identities = 133/546 (24%), Positives = 222/546 (40%), Gaps = 55/546 (10%)
Query: 28 DHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGE--LHLEEVSPDVVAQV 85
++G+ D ++ G + CH+LVLA PYFRA FL+E A + + + + D + +
Sbjct: 62 ENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDL 121
Query: 86 LHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDC 145
+ ++Y+S + L +VQ L AA Q+ + C +++ SNCLAV +
Sbjct: 122 VKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNR 181
Query: 146 ARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSG 205
L A + C HFT V DF+ +S L ++SS LN+E E+ V+ A ++W +
Sbjct: 182 IDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLAN 241
Query: 206 DAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDAHEGRI 265
+ L VR LLP FL V + +V+ + + ++ H
Sbjct: 242 ----PQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYH---- 293
Query: 266 TTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLIFMISE 325
S + E + R P ++F +
Sbjct: 294 -------------------LHLSSRAVPDFEYSIRTTP---------RKHTAGVLFCVGG 325
Query: 326 EGAVAYDPAANECYCASLSN-------QVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPM 378
G + ECY + ++ + HV +++ E +V+ GG NE M
Sbjct: 326 RGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEM 385
Query: 379 SAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRL 438
FD L ++W+ + + R L IY +GG D C + V YD
Sbjct: 386 ------FDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGG---LDDNTCFNDVERYDIE 436
Query: 439 SFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQT 498
S +W P+ G ++ ++ VY +GG L+ + YDP +W E+ M
Sbjct: 437 SDQWSTVAPMNTPRGGVGSVALVNHVYAVGG-NDGMASLSSVERYDPHLDKWIEVKEMGQ 495
Query: 499 ARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGT 558
R+ G + G + V G D SS E Y NKW A R + + +++G
Sbjct: 496 RRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGK 555
Query: 559 LYAIGG 564
++A+GG
Sbjct: 556 IFAVGG 561
Score = 75.9 bits (185), Expect = 1e-13
Identities = 57/207 (27%), Positives = 83/207 (40%), Gaps = 13/207 (6%)
Query: 390 SEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWGESDPLP 449
+ W P + S R G+ +Y VGG DG L S+ +D L+ KW +
Sbjct: 344 NSWFFGPEMNSRRRHVGVISVEGKVYAVGGH---DGNEHLGSMEMFDPLTNKWMMKASMN 400
Query: 450 YVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHD 509
G + S +Y IGG D C N + YD + +W +APM T R G+
Sbjct: 401 TKRRGIALASLGGPIYAIGGL-DDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALV 459
Query: 510 GRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGGFATLE 569
+ G SS E Y +KW + Q R+ + L G LY +GGF
Sbjct: 460 NHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDD-- 517
Query: 570 TESGELVPTELNDIWRYNEEEKKWEGV 596
+ L+ + RY+ KW+ V
Sbjct: 518 -------NSPLSSVERYDPRSNKWDYV 537
Score = 51.2 bits (121), Expect = 3e-06
Identities = 34/134 (25%), Positives = 54/134 (40%), Gaps = 9/134 (6%)
Query: 463 LVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTG 522
+++ +GG+G + Y K W M + R G +G++ G
Sbjct: 319 VLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNE 378
Query: 523 LTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGGFATLETESGELVPTELND 582
S E++ NKW + +R ++L SL G +YAIGG T ND
Sbjct: 379 HLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDD---------NTCFND 429
Query: 583 IWRYNEEEKKWEGV 596
+ RY+ E +W V
Sbjct: 430 VERYDIESDQWSTV 443
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 157 bits (397), Expect = 3e-38
Identities = 139/562 (24%), Positives = 235/562 (41%), Gaps = 51/562 (9%)
Query: 23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAE--PERAGELHLEEVSPD 80
++ L + D ++ G R+ P HRLVL++ S YF A F ++ + E+ +E + P+
Sbjct: 202 MESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPN 261
Query: 81 VVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLG 140
+ ++ + YT + L E ++++L AAA Q+P + +C FL K L SNCL +
Sbjct: 262 ALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFA 321
Query: 141 LLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMR 200
C L A + + V R+ +FL L A+EL +++SD +NV EE +F A+M
Sbjct: 322 DAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMM 381
Query: 201 WAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDA 260
W R L + +R LLP L + +E H L + E + +
Sbjct: 382 WV----KYDMQSRCNDLSMLLAFIRLPLLPPQIL-ADLENHALFKNDLECQKLILEAMKY 436
Query: 261 H--EGRITTLR----KKKKGKDG----AGAKEADKGTSKAKAEEDEEAERILPGILND-T 309
H R T ++ K +K G G + +KG + + + I G++N
Sbjct: 437 HLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRR 496
Query: 310 LRFGM-FLQDLIFMI-SEEGAVAYDPAANECYCASLSN-------QVPKNHVSLVTKENQ 360
L+FG+ + D +F+I +G + ECY ++ + + E
Sbjct: 497 LQFGVAVIDDKLFVIGGRDGLKTLNTV--ECYNPKTKTWTVLPPMSTHRHGLGVTVLEGP 554
Query: 361 VFVAGG----LFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYV 416
++ GG + N + DP S +W + + R G+ +Y
Sbjct: 555 IYAVGGHDGWSYLNTVERWDPQS----------QQWTFVASMSIARSTVGVAALNGKLYS 604
Query: 417 VGGREIKDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSD--- 473
VGGR DG CL S+ YD + KW P+ G V + +Y +GG +
Sbjct: 605 VGGR---DGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASN 661
Query: 474 --RKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYS 531
+ L+ + YDPK W +AP+ R G + R+ G ++ E Y
Sbjct: 662 HCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYD 721
Query: 532 ITDNKWAPFEAFPQERSSLSLV 553
N+W + R+ +V
Sbjct: 722 PQTNEWTQMASLNIGRAGACVV 743
Score = 74.3 bits (181), Expect = 3e-13
Identities = 53/210 (25%), Positives = 92/210 (43%), Gaps = 7/210 (3%)
Query: 384 QFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWG 443
++D + W+ + R FG+ + ++V+GGR DG + L++V CY+ + W
Sbjct: 478 KYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGR---DGLKTLNTVECYNPKTKTWT 534
Query: 444 ESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLF 503
P+ +G V +Y +GG LN + +DP+ +W +A M ARS
Sbjct: 535 VLPPMSTHRHGLGVTVLEGPIYAVGGHDG-WSYLNTVERWDPQSQQWTFVASMSIARSTV 593
Query: 504 GATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIG 563
G +G++ G + SS E Y NKW + R + + + G LYA+G
Sbjct: 594 GVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVG 653
Query: 564 GFATLETESGELVPTELNDIWRYNEEEKKW 593
G + + L+ + RY+ + W
Sbjct: 654 GH---DAPASNHCSRLLDYVERYDPKTDTW 680
Score = 60.5 bits (145), Expect = 5e-09
Identities = 43/156 (27%), Positives = 73/156 (46%), Gaps = 8/156 (5%)
Query: 411 LNSIYVVGGREIKDGERCLDSVMCYDRLSFKWGESDPLP--YVVYGHTVLSHMDLVYVIG 468
+ ++Y VGG + G ++ YD + W ++ + + +G V+ D ++VIG
Sbjct: 458 VGTLYAVGGMDNNKGATTIEK---YDLRTNLWIQAGMMNGRRLQFGVAVID--DKLFVIG 512
Query: 469 GKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAE 528
G+ K LN + Y+PK W L PM T R G TV +G I G ++ E
Sbjct: 513 GRDG-LKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVE 571
Query: 529 VYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGG 564
+ +W + RS++ + +L G LY++GG
Sbjct: 572 RWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGG 607
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 157 bits (396), Expect = 4e-38
Identities = 153/598 (25%), Positives = 246/598 (41%), Gaps = 77/598 (12%)
Query: 13 LYQQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARF---LAEPERA 69
L+ + LLQ GL + H + D ++R G+ + H++VLA+ SPYF+A F L+E E +
Sbjct: 16 LHSEQLLQ-GLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENS 74
Query: 70 GELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLC 129
E+ + + + ++ Y YT + + + +V+ L AA+ QI + C +FL+ +L
Sbjct: 75 -EVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLD 133
Query: 130 LSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVE 189
NC+ + R C L +AA +IC +F V + +F L+ +L I+S+D LNV
Sbjct: 134 PGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVA 193
Query: 190 KEEAVFEAVMRWAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLV---RA 246
EE VF A+ W D + ERQ+ L + SVR LL FL E + L+ R
Sbjct: 194 TEETVFYALESWI-KYDVQ---ERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRT 249
Query: 247 QPELLRKVQMVKDAHEGRI---TTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILP 303
LL + E R+ T L + + A ++L
Sbjct: 250 CKHLLNEALKYHFMPEHRLSHQTVLMTRPRC-----------------------APKVLC 286
Query: 304 GILNDTLRFGMFLQDLIFMISEEGAVAYDPAANECYCASLSNQVPKNHVSLVTKENQVFV 363
+ + F + Y P N+ + +P+ + + +V+V
Sbjct: 287 AVGGKSGLFACL----------DSVEMYFPQ-NDSWIGLAPLNIPRYEFGICVLDQKVYV 335
Query: 364 AGGLFYNED------NKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVV 417
GG+ N E+ + + + + W + + R G+ +Y +
Sbjct: 336 IGGIATNVRPGVTIRKHENSVECW----NPDTNTWTSLERMNESRSTLGVVVLAGELYAL 391
Query: 418 GGREIKDGERCLDSVMCYDRLSFKWGESDPLPYV--VYGHTVLSHMDLVYVIGGKGSDRK 475
GG DG+ L SV Y KW P+ + VL M +Y IGG G
Sbjct: 392 GGY---DGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGM--IYAIGGYGPAH- 445
Query: 476 CLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDN 535
+N + YDP K W+ +A M R FG V G I V G SS E Y N
Sbjct: 446 -MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQN 504
Query: 536 KWAPFEAFPQERSSLSLVSLVGTLYAIGGFATLETESGELVPTELNDIWRYNEEEKKW 593
+W + R+ + + LY +GG SG + LN + +Y+ W
Sbjct: 505 QWTVCRPMKEPRTGVGAAVIDNYLYVVGG------HSGS---SYLNTVQKYDPISDTW 553
Score = 70.9 bits (172), Expect = 3e-12
Identities = 79/287 (27%), Positives = 111/287 (38%), Gaps = 43/287 (14%)
Query: 326 EGAVAYDPAANECYCASLSNQV--PKNHVSLVTKENQVFVAGGLFYNEDNKE----DPMS 379
E + YD + Y A L N V P V +T+ ++ A L ++ + + +
Sbjct: 203 ESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTR---LYEANHLIRDDRTCKHLLNEALK 259
Query: 380 AYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGE-RCLDSVMCYDRL 438
+F+ L + + M PRC A + VGG K G CLDSV Y
Sbjct: 260 YHFMPEHRLSHQTVLMT---RPRC------APKVLCAVGG---KSGLFACLDSVEMYFPQ 307
Query: 439 SFKWGESDPL--PYVVYGHTVLSHMDLVYVIGGKGSD-------RKCLNKMCVYDPKKFE 489
+ W PL P +G VL VYVIGG ++ RK N + ++P
Sbjct: 308 NDSWIGLAPLNIPRYEFGICVLDQK--VYVIGGIATNVRPGVTIRKHENSVECWNPDTNT 365
Query: 490 WKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSS 549
W L M +RS G V G + G S E Y KW P RS
Sbjct: 366 WTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSC 425
Query: 550 LSLVSLVGTLYAIGGFATLETESGELVPTELNDIWRYNEEEKKWEGV 596
+ L G +YAIGG+ P +N + RY+ + WE V
Sbjct: 426 FAAAVLDGMIYAIGGYG----------PAHMNSVERYDPSKDSWEMV 462
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 154 bits (389), Expect = 2e-37
Identities = 138/573 (24%), Positives = 239/573 (41%), Gaps = 53/573 (9%)
Query: 32 FLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGE--LHLEEVSPDVVAQVLHYL 89
F D ++ G+ F HRLVLAA SPYF A F + + + + + + + +L ++
Sbjct: 36 FCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFI 95
Query: 90 YTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDCARLA 149
YT + + +VQ+L AA Q+ + +C FL+ ++ NC+ +F+ + C L
Sbjct: 96 YTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLL 155
Query: 150 VAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGDAEA 209
+ ++I HF V +FL L+ D+LI I+ S+ L++E E VF A M+W +
Sbjct: 156 EFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWI----LKD 211
Query: 210 QAERQRALPTVFESVRCRLLP----RAFLESRVERHPLVRAQPELLRKVQMVKDAHEGRI 265
+R++ + V + +R LLP ++E + + V Q L ++ K E +
Sbjct: 212 LGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKF 271
Query: 266 TTLRKKKKGKDGAGAKE---ADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLIFM 322
+ + K + A++ A G ++ + ++ L+ RF F Q
Sbjct: 272 CSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSR-----ALSCVERFDTFSQ----- 321
Query: 323 ISEEGAVAYDPAANECYCASLSNQVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYF 382
Y ++S+ + V V GG+ Y ++D M
Sbjct: 322 ----------------YWTTVSS------LHQARSGLGVTVLGGMVYAIGGEKDSMIFDC 359
Query: 383 LQ-FDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFK 441
+ +D + +W + + PRC G+ +IY +GG G +++ +D K
Sbjct: 360 TECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWV---GAEIGNTIERFDPDENK 416
Query: 442 WGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARS 501
W + Y L+YVIGG ++ L VYDP W L PM T R+
Sbjct: 417 WEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRA 476
Query: 502 LFGATVHDGRIIVAAGVTDT-GLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLY 560
G + I G +T + E YS + KW + R+ + +V++ G LY
Sbjct: 477 YLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLY 536
Query: 561 AIGGFATLETESGELVPTELNDIWRYNEEEKKW 593
GG + L P L+ + YN W
Sbjct: 537 VSGG---RSSSHDFLAPGTLDSVEVYNPHSDTW 566
Score = 58.2 bits (139), Expect = 2e-08
Identities = 40/147 (27%), Positives = 61/147 (41%), Gaps = 17/147 (11%)
Query: 450 YVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHD 509
Y V G+T L GG+ SD + L+ + +D W ++ + ARS G TV
Sbjct: 291 YAVGGYTRLQ--------GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLG 342
Query: 510 GRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGGFATLE 569
G + G D+ + E Y +W + R L + G +YA+GG+ E
Sbjct: 343 GMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAE 402
Query: 570 TESGELVPTELNDIWRYNEEEKKWEGV 596
N I R++ +E KWE V
Sbjct: 403 IG---------NTIERFDPDENKWEVV 420
Score = 52.4 bits (124), Expect = 1e-06
Identities = 48/183 (26%), Positives = 76/183 (41%), Gaps = 15/183 (8%)
Query: 331 YDPAANECYCASLSNQVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDS 390
+DP N+ + V + + + ++V GG+ + E F +D L
Sbjct: 410 FDPDENKWEVVG-NMAVSRYYFGCCEMQGLIYVIGGI-----SNEGIELRSFEVYDPLSK 463
Query: 391 EWLGMPPLPSPRCLFGLGEALNSIYVVGG-REIKDGERCLDSVMCYDRLSFKWGESDPLP 449
W +PP+ + R G+ + IY VGG E +D L +V Y KW E +
Sbjct: 464 RWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDA---LHTVEKYSFEEEKWVEVASMK 520
Query: 450 YVVYGHTVLSHMDLVYVIGGKGSDRK-----CLNKMCVYDPKKFEWKELAPMQTARSLFG 504
G V++ L+YV GG+ S L+ + VY+P W E+ M T+R G
Sbjct: 521 VPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGG 580
Query: 505 ATV 507
V
Sbjct: 581 VAV 583
>gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Homo
sapiens]
Length = 623
Score = 154 bits (388), Expect = 3e-37
Identities = 148/563 (26%), Positives = 225/563 (39%), Gaps = 81/563 (14%)
Query: 14 YQQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLA--EPERAGE 71
Y +LL+ LK + F D V+ EFPCH++VLA CS YFRA F++ +
Sbjct: 13 YAVSLLEQ-LKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTH 71
Query: 72 LHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLS 131
+HL V + ++ Y YT +A+++++V+ L+ A Q+ + C +L K++
Sbjct: 72 VHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAE 131
Query: 132 NCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKE 191
NC+ + L C L +A+ + FT V F+ LS D LI I+SSD LNVEKE
Sbjct: 132 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKE 191
Query: 192 EAVFEAVMRWAGSGDAEAQAE-RQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPEL 250
E V EA M W E E R + L +V +R L S V + + P
Sbjct: 192 ETVREAAMLW-----LEYNTESRSQYLSSVLSQIRIDAL------SEVTQRAWFQGLPPN 240
Query: 251 LRKVQMVKDAHEGRITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTL 310
+ V + +G ++ K K + G KE +A +E
Sbjct: 241 DKSVVV-----QGLYKSMPKFFKPRLGM-TKEEMMIFIEASSENP--------------- 279
Query: 311 RFGMFLQDLIFMISEEGAVAYDPAANECYCASLSNQVPKNHVSLVTKENQVFVAGGLFYN 370
S +V Y P A + Y ++VT +N +++AGG
Sbjct: 280 ------------CSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPL 327
Query: 371 EDNKEDPMSAYFLQ-----------FDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGG 419
++ K + LQ FD + W P+ R L IY +GG
Sbjct: 328 KNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGG 387
Query: 420 REIKDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNK 479
+ GE +V YD +W PLP + D +YV+ LN
Sbjct: 388 DSV-GGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVM--------TLNL 438
Query: 480 MCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGV-------------TDTGLTSS 526
M Y P+ W E+A QT+RS A +I G+ T G + +
Sbjct: 439 MYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVT 498
Query: 527 AEVYSITDNKWAPFEAFPQERSS 549
E+Y + N+W P +R S
Sbjct: 499 VEIYDVNKNEWKMAANIPAKRYS 521
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 152 bits (384), Expect = 9e-37
Identities = 140/576 (24%), Positives = 240/576 (41%), Gaps = 57/576 (9%)
Query: 32 FLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGE--LHLEEVSPDVVAQVLHYL 89
F D ++ G+ F HRLVLAA SPYF A F + + + + + + + +L ++
Sbjct: 36 FCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFI 95
Query: 90 YTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDCARLA 149
YT + + +VQ+L AA Q+ + +C FL+ ++ NC+ +F+ + C L
Sbjct: 96 YTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLL 155
Query: 150 VAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGDAEA 209
+ ++I HF V +FL L+ D+LI I+ S+ L++E E VF A M+W +
Sbjct: 156 EFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWI----LKD 211
Query: 210 QAERQRALPTVFESVRCRLLP----RAFLESRVERHPLVRAQPELLRKVQMVKDAHEGRI 265
+R++ + V + +R LLP ++E + + V Q L ++ K E +
Sbjct: 212 LGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKF 271
Query: 266 TTLRKKKKGKDGAGAKE---ADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLIFM 322
+ + K + A++ A G ++ + ++ L+ RF F Q
Sbjct: 272 CSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSR-----ALSCVERFDTFSQ----- 321
Query: 323 ISEEGAVAYDPAANECYCASLSNQVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYF 382
Y ++S+ + V V GG+ Y ++D M
Sbjct: 322 ----------------YWTTVSS------LHQARSGLGVTVLGGMVYAIGGEKDSMIFDC 359
Query: 383 LQ-FDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFK 441
+ +D + +W + + PRC G+ +IY +GG G +++ +D K
Sbjct: 360 TECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWV---GAEIGNTIERFDPDENK 416
Query: 442 WGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARS 501
W + Y L+YVIGG ++ L VYDP W L PM T R+
Sbjct: 417 WEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRA 476
Query: 502 LFGATVHDGRIIVAAGVTDT-GLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLY 560
G + I G +T + E YS + KW + R+ + +V++ G LY
Sbjct: 477 YLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLY 536
Query: 561 AIGGFATLETESGELVPTELNDIWRYNEEEKKWEGV 596
GG + L P D RY KWE +
Sbjct: 537 VSGG---RSSSHDFLAP----DTHRYEVFRLKWENM 565
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 150 bits (380), Expect = 3e-36
Identities = 137/538 (25%), Positives = 231/538 (42%), Gaps = 51/538 (9%)
Query: 43 EFPCHRLVLAACSPYFRARFLAEPERAGE--LHLEEVSPDVVAQVLHYLYTSEIALDEAS 100
+F H++VLA+ SP F+A F G + +E + P V+ +++ + YT+ I++ E
Sbjct: 92 QFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKC 151
Query: 101 VQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDCARLAVAARDFICAHF 160
V + A +QI S+ C FL ++L SN + + + C L AR++I HF
Sbjct: 152 VLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHF 211
Query: 161 TLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGDAEAQAERQRALPTV 220
VA+ +F LS +L+ +IS D LNV E VF A + W D E +R+ + +
Sbjct: 212 GEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWV-KYDCE---QRRFYVQAL 267
Query: 221 FESVRCRLLPRAFLESRVERHPLV----RAQPELLRKVQMVKDAHEGRITTLRKKKKGK- 275
+VRC L FL+ ++++ ++ R + L++ + + ++ R K G+
Sbjct: 268 LRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRL 327
Query: 276 --DGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLIFMI-----SEEGA 328
G +A D R+ + + G + L++ + S +G
Sbjct: 328 IYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGN 387
Query: 329 VAYDPAANECY---------CASLSNQVPKNHVSLVTKENQVFVAGG----LFYNEDNKE 375
D +A +CY CA +S VP+N + + + ++ GG + +N +
Sbjct: 388 T--DSSALDCYNPMTNQWSPCAPMS--VPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERY 443
Query: 376 DPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCY 435
+P EW + P+ + R G+ +Y VGG DG L+S CY
Sbjct: 444 EPER----------DEWHLVAPMLTRRIGVGVAVLNRLLYAVGG---FDGTNRLNSAECY 490
Query: 436 DRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGG-KGSDRKCLNKMCVYDPKKFEWKELA 494
+W + + G V + +Y GG G D+ LN + YD + W +A
Sbjct: 491 YPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQ--LNSVERYDVETETWTFVA 548
Query: 495 PMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSL 552
PM+ RS G TVH GRI V G S E Y + W+ RS + +
Sbjct: 549 PMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGV 606
Score = 77.0 bits (188), Expect = 5e-14
Identities = 73/274 (26%), Positives = 112/274 (40%), Gaps = 50/274 (18%)
Query: 361 VFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPR-----CLFGLGEALNSIY 415
++ AGG F +Y ++ D WL + L PR C+ G +Y
Sbjct: 328 IYTAGGYFRQS-------LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVG-----GLLY 375
Query: 416 VVGGREIK-DGERCLDSVMCYDRLSFKWGESDPLPY--------VVYGHTVLSHMDLVYV 466
VGGR DG ++ CY+ ++ +W P+ V+ GH +Y
Sbjct: 376 AVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGH--------IYA 427
Query: 467 IGGKGSDRKCLNKMCV--YDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLT 524
+GG C++ V Y+P++ EW +APM T R G V + + G T
Sbjct: 428 VGGSHG---CIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRL 484
Query: 525 SSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGGFATLETESGELVPTELNDIW 584
+SAE Y N+W A RS + L +YA GG+ G+ +LN +
Sbjct: 485 NSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY------DGQ---DQLNSVE 535
Query: 585 RYNEEEKKWEGV--LREIAYAAGATFLPVRLNVL 616
RY+ E + W V ++ A G T R+ VL
Sbjct: 536 RYDVETETWTFVAPMKHRRSALGITVHQGRIYVL 569
Score = 31.6 bits (70), Expect = 2.3
Identities = 19/55 (34%), Positives = 25/55 (45%)
Query: 510 GRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGG 564
GR+I AG S E Y+ +D W RS L+ + G LYA+GG
Sbjct: 325 GRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGG 379
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 150 bits (380), Expect = 3e-36
Identities = 137/538 (25%), Positives = 231/538 (42%), Gaps = 51/538 (9%)
Query: 43 EFPCHRLVLAACSPYFRARFLAEPERAGE--LHLEEVSPDVVAQVLHYLYTSEIALDEAS 100
+F H++VLA+ SP F+A F G + +E + P V+ +++ + YT+ I++ E
Sbjct: 92 QFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKC 151
Query: 101 VQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDCARLAVAARDFICAHF 160
V + A +QI S+ C FL ++L SN + + + C L AR++I HF
Sbjct: 152 VLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHF 211
Query: 161 TLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGDAEAQAERQRALPTV 220
VA+ +F LS +L+ +IS D LNV E VF A + W D E +R+ + +
Sbjct: 212 GEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWV-KYDCE---QRRFYVQAL 267
Query: 221 FESVRCRLLPRAFLESRVERHPLV----RAQPELLRKVQMVKDAHEGRITTLRKKKKGK- 275
+VRC L FL+ ++++ ++ R + L++ + + ++ R K G+
Sbjct: 268 LRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRL 327
Query: 276 --DGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLIFMI-----SEEGA 328
G +A D R+ + + G + L++ + S +G
Sbjct: 328 IYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGN 387
Query: 329 VAYDPAANECY---------CASLSNQVPKNHVSLVTKENQVFVAGG----LFYNEDNKE 375
D +A +CY CA +S VP+N + + + ++ GG + +N +
Sbjct: 388 T--DSSALDCYNPMTNQWSPCAPMS--VPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERY 443
Query: 376 DPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCY 435
+P EW + P+ + R G+ +Y VGG DG L+S CY
Sbjct: 444 EPER----------DEWHLVAPMLTRRIGVGVAVLNRLLYAVGG---FDGTNRLNSAECY 490
Query: 436 DRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGG-KGSDRKCLNKMCVYDPKKFEWKELA 494
+W + + G V + +Y GG G D+ LN + YD + W +A
Sbjct: 491 YPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQ--LNSVERYDVETETWTFVA 548
Query: 495 PMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSL 552
PM+ RS G TVH GRI V G S E Y + W+ RS + +
Sbjct: 549 PMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGV 606
Score = 77.0 bits (188), Expect = 5e-14
Identities = 73/274 (26%), Positives = 112/274 (40%), Gaps = 50/274 (18%)
Query: 361 VFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPR-----CLFGLGEALNSIY 415
++ AGG F +Y ++ D WL + L PR C+ G +Y
Sbjct: 328 IYTAGGYFRQS-------LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVG-----GLLY 375
Query: 416 VVGGREIK-DGERCLDSVMCYDRLSFKWGESDPLPY--------VVYGHTVLSHMDLVYV 466
VGGR DG ++ CY+ ++ +W P+ V+ GH +Y
Sbjct: 376 AVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGH--------IYA 427
Query: 467 IGGKGSDRKCLNKMCV--YDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLT 524
+GG C++ V Y+P++ EW +APM T R G V + + G T
Sbjct: 428 VGGSHG---CIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRL 484
Query: 525 SSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGGFATLETESGELVPTELNDIW 584
+SAE Y N+W A RS + L +YA GG+ G+ +LN +
Sbjct: 485 NSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY------DGQ---DQLNSVE 535
Query: 585 RYNEEEKKWEGV--LREIAYAAGATFLPVRLNVL 616
RY+ E + W V ++ A G T R+ VL
Sbjct: 536 RYDVETETWTFVAPMKHRRSALGITVHQGRIYVL 569
Score = 31.6 bits (70), Expect = 2.3
Identities = 19/55 (34%), Positives = 25/55 (45%)
Query: 510 GRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGG 564
GR+I AG S E Y+ +D W RS L+ + G LYA+GG
Sbjct: 325 GRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGG 379
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 150 bits (379), Expect = 3e-36
Identities = 139/543 (25%), Positives = 222/543 (40%), Gaps = 50/543 (9%)
Query: 32 FLDCVVRAGEREFPCHRLVLAACSPYFRARF---LAEPERAGELHLEEVSPDVVAQVLHY 88
F D ++ AG R FPCHR VLAACS YF A F L E + + + P+V+ +L Y
Sbjct: 45 FTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDY 104
Query: 89 LYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDCARL 148
Y+S + ++E + + L A + I C FL+K L +NCL + L C +L
Sbjct: 105 AYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKL 164
Query: 149 AVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGDAE 208
+ ++F + ++ DFL L D ++ ++SS+ L E E V+E+ + W S D +
Sbjct: 165 YELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWI-SYDLK 223
Query: 209 AQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVKDAHEGRITTL 268
+R LP + ++VR LLP +L V L+ Q + ++V++A ++ L
Sbjct: 224 ---KRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQ---RKSKEIVEEAIRCKLKIL 277
Query: 269 RKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLIFMISEEGA 328
+ DG A+ + A +L G F+ D ++++ ++
Sbjct: 278 Q-----NDGVVTSLC------ARPRKTGHALFLLGG--------QTFMCDKLYLVDQKAK 318
Query: 329 VAYDPAANECYCASLSNQVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHL 388
A P+ S +V++ GG E+ +S +D L
Sbjct: 319 EIIPKA---------DIPSPRKEFSACAIGCKVYITGG-----RGSENGVSKDVWVYDTL 364
Query: 389 DSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDG------ERCLDSVMCYDRLSFKW 442
EW P+ R G E + +YVVGG G L V YD KW
Sbjct: 365 HEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKW 424
Query: 443 GESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSL 502
PL V V+S ++ GG L K+ YD + W A
Sbjct: 425 TMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRY 484
Query: 503 FGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAI 562
A V +I + G T+ S+ + S T +W +R S V+ LY +
Sbjct: 485 TAAAVLGNQIFIMGGDTEFSACSAYKFNSET-YQWTKVGDVTAKRMSCHAVASGNKLYVV 543
Query: 563 GGF 565
GG+
Sbjct: 544 GGY 546
Score = 53.5 bits (127), Expect = 6e-07
Identities = 53/222 (23%), Positives = 88/222 (39%), Gaps = 25/222 (11%)
Query: 386 DHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWGES 445
D E + +PSPR F +Y+ GGR ++G V YD L +W ++
Sbjct: 314 DQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVS--KDVWVYDTLHEEWSKA 371
Query: 446 DPLPYVVYGHTVLSHMDLVYVIGGKGSDRKC--------LNKMCVYDPKKFEWKELAPMQ 497
P+ +GH +YV+GG + C L ++ YDP +W +AP++
Sbjct: 372 APMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLR 431
Query: 498 TARSLFGATVHDGRI-IVAAGVTDTGLTSSAEV--YSITDNKWAPFEAFPQERSSLSLVS 554
S A V ++ + A G T +V Y +N+W PQ +
Sbjct: 432 EGVS--NAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAV 489
Query: 555 LVGTLYAIGGFATLETESGELVPTELNDIWRYNEEEKKWEGV 596
L ++ +GG +TE +++N E +W V
Sbjct: 490 LGNQIFIMGG----DTEFSAC------SAYKFNSETYQWTKV 521
>gi|128485503 kelch-like 30 [Homo sapiens]
Length = 560
Score = 150 bits (378), Expect = 4e-36
Identities = 138/550 (25%), Positives = 217/550 (39%), Gaps = 56/550 (10%)
Query: 21 DGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAE--PERAGELHLEEVS 78
DGL+ + K D + G RE PCHR +LA SPYF A F + + + L +V
Sbjct: 3 DGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVE 62
Query: 79 PDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFR 138
P VV Q++ ++YT + + + +V+ L A R PS+ +C +LQ++L +NCL +
Sbjct: 63 PAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICE 122
Query: 139 LGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAV 198
G +A A F+ +F VAR+ +FL L + L+ ++ D L V+ E++ EA+
Sbjct: 123 FGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEAL 182
Query: 199 MRWAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMVK 258
MRW D +A+A LP + V +PR ++ + PL++ + E R +
Sbjct: 183 MRWV-RHDPQARAAH---LPELLSLVHLDAVPRPCVQQLLASEPLIQ-ESEACRAA--LS 235
Query: 259 DAHEGRITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQD 318
H+G L++K +E EE+E E PG+ N
Sbjct: 236 QGHDGAPLALQQK--------LEEVLVVVGGQALEEEEAGEEPTPGLGNFAF-------- 279
Query: 319 LIFMISEEGAVAYDPAANECYCASLSNQVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPM 378
Y+ A K SL N ++V GG + K D
Sbjct: 280 ------------YNSKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGG---SRGTKTDTW 324
Query: 379 S-AYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDR 437
S F ++ W + P+ PR IYV+GG + E V YD
Sbjct: 325 STTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVIGGTTLDVVE-----VESYDP 379
Query: 438 LSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQ 497
+ W P V + +Y++G L C Y+P W +A
Sbjct: 380 YTDSWTPVSPALKYVSNFSAAGCRGRLYLVGSSACKYNALALQC-YNPVTDAWSVIASPF 438
Query: 498 TARSLFG---ATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVS 554
+ L A +H ++ T VY N W ++ + +LV
Sbjct: 439 LPKYLSSPRCAALHGELYLIGDN------TKKVYVYDPGANLWQKVQSQHSLHENGALVP 492
Query: 555 LVGTLYAIGG 564
L LY GG
Sbjct: 493 LGDALYVTGG 502
Score = 42.7 bits (99), Expect = 0.001
Identities = 39/163 (23%), Positives = 66/163 (40%), Gaps = 12/163 (7%)
Query: 414 IYVVGGREIKDGERC------LDSVMCYDRLSFKWGESDPLP-YVVYGHTVLSHMDLVYV 466
+ VVGG+ +++ E L + Y+ + +W P Y +G ++ + + +YV
Sbjct: 253 LVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLAALNNNIYV 312
Query: 467 IGGKG---SDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGL 523
GG +D + + K+ WK +APM R+ + +G I V G T
Sbjct: 313 TGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVIGGTTLD-- 370
Query: 524 TSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGGFA 566
E Y + W P + S+ S G LY +G A
Sbjct: 371 VVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLVGSSA 413
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 148 bits (374), Expect = 1e-35
Identities = 157/590 (26%), Positives = 238/590 (40%), Gaps = 81/590 (13%)
Query: 22 GLKDMLDHGKFLDCVVRA-GEREFPCHRLVLAACSPYFRARFLAE--PERAGELHLEEVS 78
GL + KFLD + A G R+FP HR VLAA SPYFRA F + RA + L V
Sbjct: 24 GLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVP 83
Query: 79 PDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFR 138
PD++ +L + YT +A+ + + L AA Q P++ C +FLQ++L L+NCL +
Sbjct: 84 PDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQD 143
Query: 139 LGLLLDCARLAVAARDFICAHF-TLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEA 197
C+ LA AA+ FI H L A + L L+ L+ + DGL V KEEA ++
Sbjct: 144 FAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLA--RLLRYLRDDGLCVPKEEAAYQL 201
Query: 198 VMRWAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPLVRAQPELLRKVQMV 257
+RW + A P + E+VR + R +L + VE PLV P LR ++
Sbjct: 202 ALRWVRADPPRRAAH----WPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREA 257
Query: 258 KDAHEGRITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQ 317
+D R D+G R G+ + G Q
Sbjct: 258 RDFQAARY---------------DRHDRGPC------PRMRPRPSTGLAEILVLVGGCDQ 296
Query: 318 DLIFMISEEGAVAYDPAANEC-YCASLSNQVPKNHVSLVTKENQVFVAGGLFYNEDNKED 376
D +++ + Y+P + Y A + + + S+V N ++V GG D
Sbjct: 297 DCDELVTVD---CYNPQTGQWRYLAEFPDHLGGGY-SIVALGNDIYVTGG--------SD 344
Query: 377 PMSAY--FLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMC 434
Y +++ +EW + P+ R +YVV DS
Sbjct: 345 GSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAA----------DSTER 394
Query: 435 YDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWK--- 491
YD + W P+ Y + + + +Y IG + M YDP W
Sbjct: 395 YDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMV--MQCYDPDTDLWSLVD 452
Query: 492 --ELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSS 549
+L P A AT++ V ++ +VY+ T N+W + Q
Sbjct: 453 CGQLPPWSFAPKT--ATLNGLMYFVRDD------SAEVDVYNPTRNEWDKIPSMNQVHVG 504
Query: 550 LSLVSLVGTLYAIGGFATLETESGELVPTELNDIWR-YNEEEKKWEGVLR 598
SL L G LY GG+ EL+D+ Y+ E + W V R
Sbjct: 505 GSLAVLGGKLYVSGGYDN---------TFELSDVVEAYDPETRAWSVVGR 545
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,176,711
Number of Sequences: 37866
Number of extensions: 1034064
Number of successful extensions: 3838
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 158
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 2857
Number of HSP's gapped (non-prelim): 443
length of query: 621
length of database: 18,247,518
effective HSP length: 108
effective length of query: 513
effective length of database: 14,157,990
effective search space: 7263048870
effective search space used: 7263048870
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.