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Search of human proteins with 109150407
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109150407 kelch-like 6 [Homo sapiens]
(621 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109150407 kelch-like 6 [Homo sapiens] 1263 0.0
gi|40018614 DRE1 protein [Homo sapiens] 502 e-142
gi|88196794 kelch-like 35 [Homo sapiens] 295 6e-80
gi|40807500 kelch-like 20 [Homo sapiens] 282 7e-76
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 272 6e-73
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 272 6e-73
gi|11056006 kelch-like 12 [Homo sapiens] 268 1e-71
gi|55925608 kelch-like 21 [Homo sapiens] 268 1e-71
gi|194097389 kelch-like 38 [Homo sapiens] 262 8e-70
gi|166235129 kelch-like 3 [Homo sapiens] 261 1e-69
gi|55925604 kelch-like 18 [Homo sapiens] 261 1e-69
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 258 9e-69
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 258 9e-69
gi|40255071 kelch-like 23 [Homo sapiens] 254 1e-67
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 251 1e-66
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 251 1e-66
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 251 2e-66
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 246 3e-65
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 244 2e-64
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 242 6e-64
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 242 8e-64
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 241 1e-63
gi|14780904 kelch-like 1 protein [Homo sapiens] 240 2e-63
gi|38194229 kelch-like 17 [Homo sapiens] 239 4e-63
gi|148664209 kelch-like 10 [Homo sapiens] 235 8e-62
gi|8922854 kelch-like 26 [Homo sapiens] 221 1e-57
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 219 5e-57
gi|45643138 kelch-like 13 [Homo sapiens] 218 2e-56
gi|24308181 kelch-like 9 [Homo sapiens] 217 2e-56
gi|227497736 T-cell activation kelch repeat protein [Homo sapiens] 216 4e-56
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 1263 bits (3267), Expect = 0.0
Identities = 621/621 (100%), Positives = 621/621 (100%)
Query: 1 MLMAGQRGAWTMGDVVEKSLEGPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLSLILQN 60
MLMAGQRGAWTMGDVVEKSLEGPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLSLILQN
Sbjct: 1 MLMAGQRGAWTMGDVVEKSLEGPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLSLILQN 60
Query: 61 GLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDA 120
GLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDA
Sbjct: 61 GLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDA 120
Query: 121 ETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRL 180
ETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRL
Sbjct: 121 ETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRL 180
Query: 181 ADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVM 240
ADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVM
Sbjct: 181 ADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVM 240
Query: 241 SWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLS 300
SWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLS
Sbjct: 241 SWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLS 300
Query: 301 GNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHEL 360
GNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHEL
Sbjct: 301 GNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHEL 360
Query: 361 ESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLG 420
ESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLG
Sbjct: 361 ESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLG 420
Query: 421 GKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGK 480
GKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGK
Sbjct: 421 GKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGK 480
Query: 481 LATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLEDSWCL 540
LATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLEDSWCL
Sbjct: 481 LATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLEDSWCL 540
Query: 541 VTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHG 600
VTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHG
Sbjct: 541 VTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHG 600
Query: 601 SVTIRKSYTHIRRIVPGAVSV 621
SVTIRKSYTHIRRIVPGAVSV
Sbjct: 601 SVTIRKSYTHIRRIVPGAVSV 621
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 502 bits (1293), Expect = e-142
Identities = 258/542 (47%), Positives = 338/542 (62%), Gaps = 10/542 (1%)
Query: 66 RMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHT 125
R TDVI+CV+ +EF CHR VL+A S+YFRAMFCND +E E + I G+ AE M
Sbjct: 60 RDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMEC 119
Query: 126 LLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHS 185
L Y YT K IT +NVQ + E ++LFQ + DACA FL E L+P NC+GI R ADTHS
Sbjct: 120 FLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHS 179
Query: 186 LDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRH 245
L +L + +++ +Q F + EEFL+L D L + SD+L + +E VFE VM WV
Sbjct: 180 LKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYR 239
Query: 246 KPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSGNEII 305
R LL +L +VRLPLL P YFV+TVE D LI+ PE + LL EAR YH+ GNE++
Sbjct: 240 AVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMM 299
Query: 306 SERTKPRMHEFQSEVFMIIGGCTKDERFVAEVT-CLDPLRRSRLEVAKLPLTEHELESEN 364
S RT+PR SEV +++GGC + F T C DP+ +AKLP
Sbjct: 300 SPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKS----- 354
Query: 365 KKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVY 424
E+A L+N++ +SGG+ DVW YNS +N WI++ LN GRWRHKM VL GKVY
Sbjct: 355 ----EYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVY 410
Query: 425 VIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATD 484
V+GG+DG R+++VE YD F N W+E APL VSS A TS KL+VIGGGP+ +D
Sbjct: 411 VVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSD 470
Query: 485 KTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLEDSWCLVTQL 544
K Q YDP TN W L+AA+P+ +CI AVS + IYV GG +A+Y Y P+ED W V
Sbjct: 471 KVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNT 530
Query: 545 SHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTI 604
+ +CG++ CN ++YI GGR E E T+LC+DP +T +PR VS+HG VTI
Sbjct: 531 FSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTI 590
Query: 605 RK 606
+
Sbjct: 591 HR 592
>gi|88196794 kelch-like 35 [Homo sapiens]
Length = 363
Score = 295 bits (756), Expect = 6e-80
Identities = 156/368 (42%), Positives = 216/368 (58%), Gaps = 8/368 (2%)
Query: 240 MSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHL 299
M WVRH R L +LE+VRLPLL P YF+E VEAD L++ C E PLL EAR +
Sbjct: 1 MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
Query: 300 SGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHE 359
G E + RT+PR +EV ++IGGC D + + ++ D LP
Sbjct: 61 LGREAGALRTRPRRFMDLAEVIVVIGGC--DRKGLLKLPFADAYHPESQRWTPLPSLPGY 118
Query: 360 LESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVL 419
SE FA L+N+VY+SGG HDVW ++S ++ WI++ L+ GRWRHKM V+
Sbjct: 119 TRSE------FAACALRNDVYVSGGHINSHDVWMFSSHLHTWIKVASLHKGRWRHKMAVV 172
Query: 420 GGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNG 479
G+++ +GGFDGL+R+++VE YDPF N W+ AAPL VSS A S KL+VIGG G
Sbjct: 173 QGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQG 232
Query: 480 KLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLEDSWC 539
+ TDK QC+DP ++WSL++ P +C+ AVS D IYV+GG M ++ Y P D W
Sbjct: 233 GVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGLMSKIFTYDPGTDVWG 292
Query: 540 LVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHH 599
L SCG+ C+ +++I GGRD++ E V +DP + ++ + L R S H
Sbjct: 293 EAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQPSLQRCTSSH 352
Query: 600 GSVTIRKS 607
G VTI +S
Sbjct: 353 GCVTIIQS 360
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 282 bits (721), Expect = 7e-76
Identities = 181/535 (33%), Positives = 268/535 (50%), Gaps = 27/535 (5%)
Query: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAE 121
+ LR L DV+L V ++ HRV+L+A S YFRAMF +L E + ++I+ +D
Sbjct: 58 INLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDER 117
Query: 122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLA 181
M L+D+ YTS+ + + NVQ +L AA L Q + +AC FL L+P NC+GI A
Sbjct: 118 AMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFA 177
Query: 182 DTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMS 241
DTHS L + + NF +++ SEEF+ LP + L I+ SD+L V E QVF VM+
Sbjct: 178 DTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMA 237
Query: 242 WVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSG 301
WV++ ER LP VL++VRLPLL P + V TV +DPLI+ E L+ EA+ Y L
Sbjct: 238 WVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLP 297
Query: 302 NE---IISERTKPRMHEFQSEVFMIIGG-CTKDERFVAEVTCLDPLRRSRLEVAKLPLTE 357
E + RT+PR EV +GG C+ D ++ V DP VA
Sbjct: 298 QERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDA--ISSVERYDPQTNEWRMVA------ 349
Query: 358 HELESENKKWVEFACVTLKNEVYISGGKETQ---HDVWKYNSSINKW-IQIEYLNIGRWR 413
S +K+ L + +Y GG + + V +Y+ N+W + + R
Sbjct: 350 ----SMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTS 405
Query: 414 HKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVI 473
+ VLGG +Y +GG DG+ +N VE YDP N W+ A + A LY +
Sbjct: 406 VGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAV 465
Query: 474 GGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG-----AMRAL 528
GG +G + + Y+P N+W A M K + ++D IY VGG + +
Sbjct: 466 GGS-DGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSA 524
Query: 529 YAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEA 583
Y+P + W V ++ R+ G+A N +L GG D + T+ +DP+A
Sbjct: 525 ERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFD-GTTYLKTIEVFDPDA 578
Score = 48.1 bits (113), Expect = 2e-05
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 3/94 (3%)
Query: 358 HELESENKKWVEFACVTLKNEVYISGGKETQHDVW---KYNSSINKWIQIEYLNIGRWRH 414
H + + C ++ +Y GG++ ++ +YN N+W + + R
Sbjct: 488 HTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGV 547
Query: 415 KMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCW 448
+ V+ G++ +GGFDG + +E +DP N W
Sbjct: 548 GLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTW 581
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 272 bits (696), Expect = 6e-73
Identities = 173/602 (28%), Positives = 286/602 (47%), Gaps = 29/602 (4%)
Query: 25 APSTDEPSQKTG----DLVEILNGEKVKFDDAGLSLILQNGLETLRMENALTDVILCVDI 80
AP+T+ P ++ + K +F D G + L R A TD+ + V+
Sbjct: 278 APATNGPPTTDSAHGLQMLRTIGVGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEG 337
Query: 81 QEFSCHRVVLAAASNYFRAMFCNDLKE-----KYEKRIIIKGVDAETMHTLLDYTYTSKA 135
+EF H+ VLA+ S YF+ + +++ + + +++ + A+ + LL++ YT
Sbjct: 338 REFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSL 397
Query: 136 LITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQS 195
+I N + +LEAA+ FQF C SFL + L NC+G+L +A+ L ++
Sbjct: 398 VIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKA 457
Query: 196 YIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLP 255
+ +Q F ++ EE L + D + +D L E V+ETV+ W++ P+ R
Sbjct: 458 FALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAA 517
Query: 256 YVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHL---SGNEIISERTKPR 312
+L VRLP + P Y + V+ + LI+ L+ EA+ YH+ + E+ + RT+PR
Sbjct: 518 ELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPR 577
Query: 313 MHEFQSEVFMIIGG---CTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVE 369
+ +EV +++GG +R + VTC +P +A LP + E
Sbjct: 578 LSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREF--------- 628
Query: 370 FACVTLKNEVYISGGKE---TQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVI 426
F+ V+ + +Y+SGG E T DVW Y S ++ W + + + R RH +V GK+Y +
Sbjct: 629 FSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTL 688
Query: 427 GGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKT 486
GG +++VE YD N W APL V S AAT K+YV GG A
Sbjct: 689 GGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVL 748
Query: 487 QCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGA-MRALYAYSPLEDSWCLVTQLS 545
Q Y P TN WS + ++ K AV+ ++++GGA RA Y P + + ++
Sbjct: 749 QSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYARATTIYDPEKGNIKAGPNMN 808
Query: 546 HERASCGIAPCNNRLYITGG-RDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTI 604
H R C + ++Y TGG + + + ++P T +P V HG V I
Sbjct: 809 HSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVI 868
Query: 605 RK 606
+K
Sbjct: 869 KK 870
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 272 bits (696), Expect = 6e-73
Identities = 173/602 (28%), Positives = 286/602 (47%), Gaps = 29/602 (4%)
Query: 25 APSTDEPSQKTG----DLVEILNGEKVKFDDAGLSLILQNGLETLRMENALTDVILCVDI 80
AP+T+ P ++ + K +F D G + L R A TD+ + V+
Sbjct: 278 APATNGPPTTDSAHGLQMLRTIGVGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEG 337
Query: 81 QEFSCHRVVLAAASNYFRAMFCNDLKE-----KYEKRIIIKGVDAETMHTLLDYTYTSKA 135
+EF H+ VLA+ S YF+ + +++ + + +++ + A+ + LL++ YT
Sbjct: 338 REFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSL 397
Query: 136 LITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQS 195
+I N + +LEAA+ FQF C SFL + L NC+G+L +A+ L ++
Sbjct: 398 VIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKA 457
Query: 196 YIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLP 255
+ +Q F ++ EE L + D + +D L E V+ETV+ W++ P+ R
Sbjct: 458 FALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAA 517
Query: 256 YVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHL---SGNEIISERTKPR 312
+L VRLP + P Y + V+ + LI+ L+ EA+ YH+ + E+ + RT+PR
Sbjct: 518 ELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPR 577
Query: 313 MHEFQSEVFMIIGG---CTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVE 369
+ +EV +++GG +R + VTC +P +A LP + E
Sbjct: 578 LSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREF--------- 628
Query: 370 FACVTLKNEVYISGGKE---TQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVI 426
F+ V+ + +Y+SGG E T DVW Y S ++ W + + + R RH +V GK+Y +
Sbjct: 629 FSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTL 688
Query: 427 GGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKT 486
GG +++VE YD N W APL V S AAT K+YV GG A
Sbjct: 689 GGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVL 748
Query: 487 QCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGA-MRALYAYSPLEDSWCLVTQLS 545
Q Y P TN WS + ++ K AV+ ++++GGA RA Y P + + ++
Sbjct: 749 QSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYARATTIYDPEKGNIKAGPNMN 808
Query: 546 HERASCGIAPCNNRLYITGG-RDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTI 604
H R C + ++Y TGG + + + ++P T +P V HG V I
Sbjct: 809 HSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVI 868
Query: 605 RK 606
+K
Sbjct: 869 KK 870
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 268 bits (685), Expect = 1e-71
Identities = 171/536 (31%), Positives = 272/536 (50%), Gaps = 28/536 (5%)
Query: 60 NGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVD 119
N + +LR N L DV L V+ ++F HR+VLAA S+YF AMF ++L EK + + I+G+
Sbjct: 21 NSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLT 80
Query: 120 AETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILR 179
A TM LLD+ YT +T +NVQ +L AA L Q + AC FL L+P NC+GI
Sbjct: 81 ASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRD 140
Query: 180 LADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETV 239
A+TH+ L + + + ++F +++ EEF+ L + ++K D++ V E VFE V
Sbjct: 141 FAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAV 200
Query: 240 MSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHL 299
++WV+H ER LP +L+ VR+PLL P Y + ++A+P IR + L+ EA+ +HL
Sbjct: 201 INWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHL 260
Query: 300 S---GNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLT 356
+++ RT+ R+ +EV +++GG + + V DP + E + LP
Sbjct: 261 RPELRSQMQGPRTRARLG--ANEVLLVVGGFGSQQSPIDVVEKYDPKTQ---EWSFLP-- 313
Query: 357 EHELESENKKWVEFACVTLKNEVYISGGKE-----TQHDVWKYNSSIN-KWIQIEYLNIG 410
S +K A V+L + +Y+ GG + + + Y + + W + +N+
Sbjct: 314 -----SITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVR 368
Query: 411 RWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKL 470
R LG +YV GGFDG +R ++E YDP + WS + +
Sbjct: 369 RGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVI 428
Query: 471 YVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG-----AM 525
Y + GG +G + + YDP T W+ M + D IYVVGG +
Sbjct: 429 YCL-GGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHL 487
Query: 526 RALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDP 581
++ AY+ DSW VT ++ R G RLY G D N +++++ C+DP
Sbjct: 488 SSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYD-GNSLLSSIECYDP 542
Score = 46.2 bits (108), Expect = 9e-05
Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 3/77 (3%)
Query: 375 LKNEVYISGGKE-TQH--DVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDG 431
L + +Y+ GG + T H V YN + W + + R VL G++Y I G+DG
Sbjct: 471 LNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDG 530
Query: 432 LQRINNVETYDPFHNCW 448
++++E YDP + W
Sbjct: 531 NSLLSSIECYDPIIDSW 547
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 268 bits (684), Expect = 1e-71
Identities = 172/573 (30%), Positives = 280/573 (48%), Gaps = 35/573 (6%)
Query: 49 FDDAGLSLILQNGLETLRMENALTDVIL-CVDIQEFSCHRVVLAAASNYFRAMFCNDLKE 107
F D +L L GL LR E DV L ++F HR VLAAAS YFRAMF L+E
Sbjct: 12 FSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRE 71
Query: 108 KYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTE 167
+R+ + GV + + LLD++YT + ++ N + +L AA+L QF + +AC +FL +
Sbjct: 72 SRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQ 131
Query: 168 ALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDL 227
L+ NC+ + A+ S L Q +I+++ V L +E+ LP+ L L+ D L
Sbjct: 132 QLDLANCLDMQDFAEAFSCSGLASAAQRFILRH-VGELGAEQLERLPLARLLRYLRDDGL 190
Query: 228 YVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEV 287
V +E ++ + WVR P R P +LE VRLP + +Y + VEA+PL+ +CP
Sbjct: 191 CVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPC 250
Query: 288 FPLLQEARMYHLSGNEIISE----RTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPL 343
LL+EAR + + + R +PR +E+ +++GGC +D + V C +P
Sbjct: 251 LRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQ 310
Query: 344 RRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQH---DVWKYNSSINK 400
+A+ P + ++ V L N++Y++GG + VW+YNSS+N+
Sbjct: 311 TGQWRYLAEFP---------DHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNE 361
Query: 401 WIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSS 460
W ++ + R H VL G +YV+ ++ E YD + W P+ + +
Sbjct: 362 WAEVAPMLKAREYHSSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDN 414
Query: 461 FAATSHKKKLYVIGGGPNGKLATDKT---QCYDPSTNKWSLK--AAMPVEAKCINAVSFR 515
+ T+ + +LY I G LA +T QCYDP T+ WSL +P + +
Sbjct: 415 CSTTACRGRLYAI-----GSLAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLN 469
Query: 516 DRIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIAT 575
+Y V + Y+P + W + ++ +A +LY++GG D E+
Sbjct: 470 GLMYFVRDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDV 529
Query: 576 VLCWDPEAQKLTEECVLPRGVSHHGSVTIRKSY 608
V +DPE + + LP HGSV+I + +
Sbjct: 530 VEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQF 562
>gi|194097389 kelch-like 38 [Homo sapiens]
Length = 581
Score = 262 bits (669), Expect = 8e-70
Identities = 167/574 (29%), Positives = 278/574 (48%), Gaps = 29/574 (5%)
Query: 49 FDDAGLSLILQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEK 108
F D S L L +LR LTDV +C +E CHR VLA++S YFRAMFC+ +EK
Sbjct: 11 FKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREK 70
Query: 109 YEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEA 168
E ++ +KG+D T+ ++ Y YT +A I NV V+EAA++ QF ++ +AC+S+L
Sbjct: 71 SEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQ 130
Query: 169 LNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLY 228
L P NC+G++RL++ S ++LKK+ + + +F ++ S + +L L L DD
Sbjct: 131 LAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYL-GDDGL 189
Query: 229 VTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVF 288
EE +VFE +M W++H R + + + VRL + P +F + D L++ P
Sbjct: 190 CGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQ 249
Query: 289 PLLQEAR--MYHLSGNEIISERT---KPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPL 343
+L+ A+ M+ L G + + P + +Q + +++GG ++ +V
Sbjct: 250 IILETAKRQMFSLCGTTVPDCKLLLHVPPRNSYQ-DFLILLGGRKDSQQTTRDVLLYSKQ 308
Query: 344 RRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKE-------TQHDVWKYNS 396
+AKLP + + + +TL +Y+ GG H+V+ ++
Sbjct: 309 TGQWQSLAKLP----------TRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSL 358
Query: 397 SINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGF-DGLQRINNVETYDPFHNCWSEAAPLL 455
+N+W E + + R+ H+ ++ IGG +G + + ++E YD N W A +
Sbjct: 359 KLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMP 418
Query: 456 VHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFR 515
V V A ++LY+ GG + Q Y S N W ++ C AV
Sbjct: 419 VGVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLG 478
Query: 516 DRIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGR----DEKNE 571
+RI +VGG R + AY P + + + R G N+LY+TGGR D E
Sbjct: 479 ERIVIVGGYTRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIE 538
Query: 572 VIATVLCWDPEAQKLTEECVLPRGVSHHGSVTIR 605
A+ C+DPE T + LP + H +T++
Sbjct: 539 DSASFDCYDPETDTWTSQGQLPHKLFDHACLTLQ 572
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 261 bits (667), Expect = 1e-69
Identities = 189/612 (30%), Positives = 292/612 (47%), Gaps = 45/612 (7%)
Query: 13 GDVVEKSLEGPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLSLILQNGLETLRMENALT 72
G+ V+ S + + DE +Q+T + G+ K + LR + L
Sbjct: 3 GESVKLSSQTLIQAGDDEKNQRTITVNPAHMGKAFKV------------MNELRSKQLLC 50
Query: 73 DVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYTYT 132
DV++ + E HRVVLAA S YF AMF D+ E K+I IK VD +T+ L+DY YT
Sbjct: 51 DVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYT 110
Query: 133 SKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQ 192
++ +T++NVQ +L AA+L Q + + C FL L+P NC+GI AD H+ L +Q
Sbjct: 111 AEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQ 170
Query: 193 VQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLC 252
+Y Q+F +++ EEFL L +D + ++ SD L V+ E +VFE V+SW+ ++ RL
Sbjct: 171 ANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRLE 230
Query: 253 LLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSGNE----IISER 308
+ ++E+VRLPLL Y V+TVE + LI+ L EA YHL + I + R
Sbjct: 231 HMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPR 290
Query: 309 TKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWV 368
TKPR +V +++GG + + + V C D ++A+LP +
Sbjct: 291 TKPRTPVSLPKVMIVVGG--QAPKAIRSVECYDFEEDRWDQIAELP----------SRRC 338
Query: 369 EFACVTLKNEVYISGGKETQ---HDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYV 425
V + VY GG V Y+ ++W I + R VL +Y
Sbjct: 339 RAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYA 398
Query: 426 IGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPN-GKLATD 484
+GGFDG + +VE Y N W AP+ SS + KLY +GG +
Sbjct: 399 VGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLS 458
Query: 485 KTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG-----AMRALYAYSPLEDSWC 539
+ Y+P+TN+W A M ++Y GG +++ Y P ++W
Sbjct: 459 TVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWK 518
Query: 540 LVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLP----RG 595
V ++ R + G+ N LY+ GG D+ + +A+V ++P K T +LP G
Sbjct: 519 QVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPVTDKWT---LLPTNMSTG 574
Query: 596 VSHHGSVTIRKS 607
S+ G I KS
Sbjct: 575 RSYAGVAVIHKS 586
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 261 bits (667), Expect = 1e-69
Identities = 162/532 (30%), Positives = 263/532 (49%), Gaps = 23/532 (4%)
Query: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAE 121
+E +R + L DV L + +FS HR+VLAA+ YF AMF ND+ E + I+++G+D
Sbjct: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
Query: 122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLA 181
+ L+++ Y I +QNVQ +L A+ Q + DAC +FL E L+P+NC+G+ + A
Sbjct: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
Query: 182 DTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMS 241
+T L S+I Q+FV++ SEEFL LP++ + ++ D+L V E QVFE ++
Sbjct: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALA 207
Query: 242 WVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSG 301
WVR+ +R LP +L N+RLPL P + + V+ D L+R C + L+ EA+ YHL
Sbjct: 208 WVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMP 267
Query: 302 N---EIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEH 358
+ + RT+PR + + +GG + V DP+ +
Sbjct: 268 ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARS 327
Query: 359 ELESENKKWVEFACVTLKNEVYISGGKETQ---HDVWKYNSSINKWIQIEYLNIGRWRHK 415
+ + +Y GG + Q V YN + W ++ +N R
Sbjct: 328 RV----------GVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMG 377
Query: 416 MVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGG 475
VVL G++YV GG+DG +++VETY P + W+ + + S+ T + ++YV G
Sbjct: 378 TVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYV-SG 436
Query: 476 GPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVG-----GAMRALYA 530
G +G + Y+ T W A M + A S +++V G G +
Sbjct: 437 GHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEM 496
Query: 531 YSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPE 582
YS + D WCL+ + R+ + RLY GG D ++ +++V +DPE
Sbjct: 497 YSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSN-LSSVEMYDPE 547
Score = 55.5 bits (132), Expect = 1e-07
Identities = 29/105 (27%), Positives = 53/105 (50%), Gaps = 3/105 (2%)
Query: 356 TEHELESENKKWVEFACVTLKNEVYISGGKETQHDVW---KYNSSINKWIQIEYLNIGRW 412
T H K +L +++++ GG + + Y+S ++W I ++ R
Sbjct: 456 TWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRS 515
Query: 413 RHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVH 457
R +V G++Y +GG+DG +++VE YDP +CW+ AP+ H
Sbjct: 516 RVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACH 560
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 258 bits (660), Expect = 9e-69
Identities = 172/559 (30%), Positives = 269/559 (48%), Gaps = 27/559 (4%)
Query: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAE 121
+ LR +N L DV + + E S HRVVLAA S YF AMF ++ E KR+ IK VD
Sbjct: 50 MNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGW 109
Query: 122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLA 181
T+ L+DY YT++ +T++NVQ +L AA L Q + C FL L+P NC+GI A
Sbjct: 110 TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFA 169
Query: 182 DTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMS 241
D H+ L + +Y Q+F ++ SEEFL+L ++ + ++ SD L ++ E +VFE V++
Sbjct: 170 DMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIA 229
Query: 242 WVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSG 301
WV H R + ++E+VRLPLL Y V+ VE + L++ L EA YHL
Sbjct: 230 WVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLP 289
Query: 302 NE----IISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTE 357
E + S RT+ R ++ +++GG + + + V C D +VA+LP
Sbjct: 290 TEQRILMKSVRTRLRTPMNLPKLMVVVGG--QAPKAIRSVECYDFKEERWHQVAELP--- 344
Query: 358 HELESENKKWVEFACVTLKNEVYISGGKETQ---HDVWKYNSSINKWIQIEYLNIGRWRH 414
+ V + V+ GG V Y+ ++W + + R
Sbjct: 345 -------SRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTL 397
Query: 415 KMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIG 474
VL G +Y +GGFDG +++VE Y+ N W AP+ SS LY +G
Sbjct: 398 GAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVG 457
Query: 475 GGPN-GKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG-----AMRAL 528
G + +CY+ +TN+W+ A M + +Y VGG +++
Sbjct: 458 GYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSV 517
Query: 529 YAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLT- 587
Y P ++W V ++ R + G+ N LY+ GG D+ + +A+V ++P K T
Sbjct: 518 EVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPTTDKWTV 576
Query: 588 EECVLPRGVSHHGSVTIRK 606
+ G S+ G I K
Sbjct: 577 VSSCMSTGRSYAGVTVIDK 595
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 258 bits (660), Expect = 9e-69
Identities = 172/559 (30%), Positives = 269/559 (48%), Gaps = 27/559 (4%)
Query: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAE 121
+ LR +N L DV + + E S HRVVLAA S YF AMF ++ E KR+ IK VD
Sbjct: 46 MNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGW 105
Query: 122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLA 181
T+ L+DY YT++ +T++NVQ +L AA L Q + C FL L+P NC+GI A
Sbjct: 106 TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFA 165
Query: 182 DTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMS 241
D H+ L + +Y Q+F ++ SEEFL+L ++ + ++ SD L ++ E +VFE V++
Sbjct: 166 DMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIA 225
Query: 242 WVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSG 301
WV H R + ++E+VRLPLL Y V+ VE + L++ L EA YHL
Sbjct: 226 WVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLP 285
Query: 302 NE----IISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTE 357
E + S RT+ R ++ +++GG + + + V C D +VA+LP
Sbjct: 286 TEQRILMKSVRTRLRTPMNLPKLMVVVGG--QAPKAIRSVECYDFKEERWHQVAELP--- 340
Query: 358 HELESENKKWVEFACVTLKNEVYISGGKETQ---HDVWKYNSSINKWIQIEYLNIGRWRH 414
+ V + V+ GG V Y+ ++W + + R
Sbjct: 341 -------SRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTL 393
Query: 415 KMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIG 474
VL G +Y +GGFDG +++VE Y+ N W AP+ SS LY +G
Sbjct: 394 GAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVG 453
Query: 475 GGPN-GKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG-----AMRAL 528
G + +CY+ +TN+W+ A M + +Y VGG +++
Sbjct: 454 GYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSV 513
Query: 529 YAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLT- 587
Y P ++W V ++ R + G+ N LY+ GG D+ + +A+V ++P K T
Sbjct: 514 EVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPTTDKWTV 572
Query: 588 EECVLPRGVSHHGSVTIRK 606
+ G S+ G I K
Sbjct: 573 VSSCMSTGRSYAGVTVIDK 591
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 254 bits (650), Expect = 1e-67
Identities = 175/571 (30%), Positives = 274/571 (47%), Gaps = 43/571 (7%)
Query: 49 FDDAGLSLILQNGLETLRMENALTDVIL-CVDIQEFSCHRVVLAAASNYFRAMFCNDLKE 107
F D+ + + T ++ TD+ L C F CHR VLAA SNYF+AMF D+KE
Sbjct: 13 FKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKE 72
Query: 108 KYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTE 167
K++ +I + G+ + + L++Y YTS+ ITK+NVQ +LEAA+L QFL + AC FL
Sbjct: 73 KFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVR 132
Query: 168 ALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDL 227
L+ +NC+G+ A+ H L+K+ + + F ++ EEFL++ ++ IL +L
Sbjct: 133 HLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNL 192
Query: 228 YVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEV 287
V +E + E V+ W H R+ L +L + + +DP Y + L R C
Sbjct: 193 SVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINID-IDPVYLKTAL---GLQRSC--- 245
Query: 288 FPLLQEARMYHLSGNEI------ISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLD 341
LL E ++ L N + IS+R+ M+ IIGG ++EV D
Sbjct: 246 --LLTENKIRSLIYNALNPMHKEISQRSTATMY--------IIGGYYWHP--LSEVHIWD 293
Query: 342 PLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQH-----DVWKYNS 396
PL ++ A++P ++ ES + L +Y++GG T + VW YNS
Sbjct: 294 PLTNVWIQGAEIP--DYTRES-------YGVTCLGPNIYVTGGYRTDNIEALDTVWIYNS 344
Query: 397 SINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLV 456
++W + + R+ H V LGG VY +GG+ E YDP W A ++
Sbjct: 345 ESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIK 404
Query: 457 HVSSFAATSHKKKLYVIGG--GPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSF 514
V + A +YVIGG G G DK Q Y+ N+WSL + P + +V F
Sbjct: 405 GVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPF 464
Query: 515 RDRIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRD-EKNEVI 573
+++Y+VGG Y P ++ W + + R CG N +Y+TGG K +
Sbjct: 465 ENKLYLVGGQTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYL 524
Query: 574 ATVLCWDPEAQKLTEECVLPRGVSHHGSVTI 604
++ +DP+ K LP + HG V +
Sbjct: 525 QSIEKYDPDLNKWEIVGNLPSAMRSHGCVCV 555
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 251 bits (642), Expect = 1e-66
Identities = 162/566 (28%), Positives = 270/566 (47%), Gaps = 43/566 (7%)
Query: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAE 121
+E L DVIL + HR+VL++ S+YF AMF ND++E ++ I ++GV+
Sbjct: 164 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPN 223
Query: 122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLA 181
++ +L+ Y YT + + + N++ +L A L Q ++V+AC FL + L+P NC+GI A
Sbjct: 224 SLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFA 283
Query: 182 DTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMS 241
D L K +Y +++F++++ ++EF+ LP + +L SDD+ + E + +++
Sbjct: 284 DAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLT 343
Query: 242 WVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSG 301
WVRH +R L +L +RLPLL P F+ +E + L R E L+ EA YHL
Sbjct: 344 WVRHDLEQRRKDLSKLLAYIRLPLLAP-QFLADMENNVLFRDDIECQKLIMEAMKYHLLP 402
Query: 302 NE---IISERTKPRMHEFQSEVFMIIG-----GCTKDERFVAEVTCLDPLRRSRLEVAKL 353
+ S RTKPR +F + G G T E++ P
Sbjct: 403 ERRPMLQSPRTKPRKSTV-GTLFAVGGMDSTKGATSIEKYDLRTNMWTP----------- 450
Query: 354 PLTEHELESENKKWVEFACVTLKNEVYISGGKE---TQHDVWKYNSSINKWIQIEYLNIG 410
+ + N + ++F L +++Y+ GG++ T + V YN W + ++
Sbjct: 451 ------VANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTH 504
Query: 411 RWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKL 470
R + VL G +Y +GG DG +N VE +DP W+ A + S+ KL
Sbjct: 505 RHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKL 564
Query: 471 YVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG------- 523
Y + GG +G +C+DP TNKW+L A M + ++ +Y +GG
Sbjct: 565 YAV-GGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASN 623
Query: 524 ----AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCW 579
+ Y P D W V +S R + G+ ++LY GG D + + TV +
Sbjct: 624 LTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQ-AYLNTVEAY 682
Query: 580 DPEAQKLTEECVLPRGVSHHGSVTIR 605
DP+ + T+ L G + VT++
Sbjct: 683 DPQTNEWTQVAPLCLGRAGACVVTVK 708
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 251 bits (642), Expect = 1e-66
Identities = 162/566 (28%), Positives = 270/566 (47%), Gaps = 43/566 (7%)
Query: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAE 121
+E L DVIL + HR+VL++ S+YF AMF ND++E ++ I ++GV+
Sbjct: 210 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPN 269
Query: 122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLA 181
++ +L+ Y YT + + + N++ +L A L Q ++V+AC FL + L+P NC+GI A
Sbjct: 270 SLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFA 329
Query: 182 DTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMS 241
D L K +Y +++F++++ ++EF+ LP + +L SDD+ + E + +++
Sbjct: 330 DAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLT 389
Query: 242 WVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSG 301
WVRH +R L +L +RLPLL P F+ +E + L R E L+ EA YHL
Sbjct: 390 WVRHDLEQRRKDLSKLLAYIRLPLLAP-QFLADMENNVLFRDDIECQKLIMEAMKYHLLP 448
Query: 302 NE---IISERTKPRMHEFQSEVFMIIG-----GCTKDERFVAEVTCLDPLRRSRLEVAKL 353
+ S RTKPR +F + G G T E++ P
Sbjct: 449 ERRPMLQSPRTKPRKSTV-GTLFAVGGMDSTKGATSIEKYDLRTNMWTP----------- 496
Query: 354 PLTEHELESENKKWVEFACVTLKNEVYISGGKE---TQHDVWKYNSSINKWIQIEYLNIG 410
+ + N + ++F L +++Y+ GG++ T + V YN W + ++
Sbjct: 497 ------VANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTH 550
Query: 411 RWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKL 470
R + VL G +Y +GG DG +N VE +DP W+ A + S+ KL
Sbjct: 551 RHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKL 610
Query: 471 YVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG------- 523
Y + GG +G +C+DP TNKW+L A M + ++ +Y +GG
Sbjct: 611 YAV-GGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASN 669
Query: 524 ----AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCW 579
+ Y P D W V +S R + G+ ++LY GG D + + TV +
Sbjct: 670 LTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQ-AYLNTVEAY 728
Query: 580 DPEAQKLTEECVLPRGVSHHGSVTIR 605
DP+ + T+ L G + VT++
Sbjct: 729 DPQTNEWTQVAPLCLGRAGACVVTVK 754
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 251 bits (640), Expect = 2e-66
Identities = 163/544 (29%), Positives = 270/544 (49%), Gaps = 43/544 (7%)
Query: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIII-KGVDA 120
L LR + TDV+L + F CHR VLAA S YF AMF LKE + + +
Sbjct: 36 LNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHP 95
Query: 121 ETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRL 180
E + LLDY Y+S+ +I ++N + +LEA ++ +F + DACA FL + L+P NC+G+L L
Sbjct: 96 EVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLL 155
Query: 181 ADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVM 240
+D H L + + NF I +E+FL LP D + +L S++L +E V+E+ +
Sbjct: 156 SDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAI 215
Query: 241 SWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEA---RMY 297
+W+ + +R C LP +L+ VRL LL Y +E V + LI + + +++EA ++
Sbjct: 216 NWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLK 275
Query: 298 HLSGNEIISER-TKPRMHEFQSEVFMIIGGCT--KDERFVAEVTCLDPLRRSRLEVAKLP 354
L + +++ +PR ++GG T D+ ++ + + AK
Sbjct: 276 ILQNDGVVTSLCARPRK---TGHALFLLGGQTFMCDKLYLVD------------QKAKEI 320
Query: 355 LTEHELESENKKWVEFACVTLKNEVYISGGKETQH----DVWKYNSSINKWIQIEYLNIG 410
+ + ++ S K EF+ + +VYI+GG+ +++ DVW Y++ +W + + +
Sbjct: 321 IPKADIPSPRK---EFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVA 377
Query: 411 RWRHKMVVLGGKVYVIGGFDGLQ---------RINNVETYDPFHNCWSEAAPLLVHVSSF 461
R+ H L +YV+GG + VE YDP N W+ APL VS+
Sbjct: 378 RFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNA 437
Query: 462 AATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVV 521
A S K KL+ GG K QCYD N+W++ A P + A ++I+++
Sbjct: 438 AVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIM 497
Query: 522 GG----AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVL 577
GG + + Y ++ W V ++ +R SC N+LY+ GG T+
Sbjct: 498 GGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQR-CKTLD 556
Query: 578 CWDP 581
C+DP
Sbjct: 557 CYDP 560
Score = 55.8 bits (133), Expect = 1e-07
Identities = 45/191 (23%), Positives = 77/191 (40%), Gaps = 29/191 (15%)
Query: 278 DPLIRQCPEVFPLLQEARMYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEV 337
DP I + V PL + +S ++S + K GG + + +V
Sbjct: 418 DPTINKWTMVAPLREG-----VSNAAVVSAKLK----------LFAFGGTSVSHDKLPKV 462
Query: 338 TCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKE--TQHDVWKYN 395
C D A P + W A L N+++I GG + +K+N
Sbjct: 463 QCYDQCENRWTVPATCP----------QPWRYTAAAVLGNQIFIMGGDTEFSACSAYKFN 512
Query: 396 SSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSE--AAP 453
S +W ++ + R V G K+YV+GG+ G+QR ++ YDP + W+ P
Sbjct: 513 SETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTVP 572
Query: 454 LLVHVSSFAAT 464
+ ++F +T
Sbjct: 573 YSLIPTAFVST 583
Score = 46.2 bits (108), Expect = 9e-05
Identities = 38/142 (26%), Positives = 61/142 (42%), Gaps = 16/142 (11%)
Query: 371 ACVTLKNEVYISGGKETQHD----VWKYNSSINKWIQIEYLNIGRWRHKMV-VLGGKVYV 425
A V+ K +++ GG HD V Y+ N+W + WR+ VLG ++++
Sbjct: 438 AVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWT-VPATCPQPWRYTAAAVLGNQIFI 496
Query: 426 IGGFDGLQRIN----NVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKL 481
+GG + N ETY W++ + S A + KLYV+GG G
Sbjct: 497 MGGDTEFSACSAYKFNSETYQ-----WTKVGDVTAKRMSCHAVASGNKLYVVGGY-FGIQ 550
Query: 482 ATDKTQCYDPSTNKWSLKAAMP 503
CYDP+ + W+ +P
Sbjct: 551 RCKTLDCYDPTLDVWNSITTVP 572
Score = 44.3 bits (103), Expect = 3e-04
Identities = 31/148 (20%), Positives = 58/148 (39%), Gaps = 14/148 (9%)
Query: 461 FAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYV 520
F+A + K+Y+ GG + + YD +WS A M V + + +YV
Sbjct: 333 FSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYV 392
Query: 521 VGG--------------AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGR 566
VGG +++ + Y P + W +V L ++ + +L+ GG
Sbjct: 393 VGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGT 452
Query: 567 DEKNEVIATVLCWDPEAQKLTEECVLPR 594
++ + V C+D + T P+
Sbjct: 453 SVSHDKLPKVQCYDQCENRWTVPATCPQ 480
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 246 bits (629), Expect = 3e-65
Identities = 167/544 (30%), Positives = 253/544 (46%), Gaps = 36/544 (6%)
Query: 58 LQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKG 117
L GL LR + L D+IL V + H+VVLA+ S YF+AMF +L EK + +
Sbjct: 21 LLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEVEFQC 80
Query: 118 VDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGI 177
+D + +++Y YT I++ V+ +L AANL Q ++ C +FL L+P NC+GI
Sbjct: 81 IDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCIGI 140
Query: 178 LRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFE 237
R A+T+ L YI QNF + +EEF +L L I+ +D L V E VF
Sbjct: 141 SRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEETVFY 200
Query: 238 TVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMY 297
+ SW+++ ER L +L +VRLPLL + EA+ LIR LL EA Y
Sbjct: 201 ALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKY 260
Query: 298 HLSGNEIISER----TKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKL 353
H +S + T+PR +V +GG + + V P S + +A L
Sbjct: 261 HFMPEHRLSHQTVLMTRPRC---APKVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPL 317
Query: 354 PLTEHELESENKKWVEFACVTLKNEVYISGG-----------KETQHDVWKYNSSINKWI 402
+ + EF L +VY+ GG ++ ++ V +N N W
Sbjct: 318 NIPRY----------EFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWT 367
Query: 403 QIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFA 462
+E +N R +VVL G++Y +GG+DG + +VE Y P W AP+ S FA
Sbjct: 368 SLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFA 427
Query: 463 ATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVG 522
A +Y IGG G + + YDPS + W + A+M + I+VVG
Sbjct: 428 AAVLDGMIYAIGG--YGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVG 485
Query: 523 G-----AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVL 577
G + ++ Y P ++ W + + R G A +N LY+ GG + + TV
Sbjct: 486 GHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGH-SGSSYLNTVQ 544
Query: 578 CWDP 581
+DP
Sbjct: 545 KYDP 548
Score = 65.9 bits (159), Expect = 1e-10
Identities = 39/135 (28%), Positives = 64/135 (47%), Gaps = 3/135 (2%)
Query: 370 FACVTLKNEVYISGGKETQH--DVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIG 427
FA L +Y GG H V +Y+ S + W + + R + V+ G ++V+G
Sbjct: 426 FAAAVLDGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVG 485
Query: 428 GFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQ 487
G +G+ ++++E YDP N W+ P+ + A LYV+GG +G + Q
Sbjct: 486 GHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGH-SGSSYLNTVQ 544
Query: 488 CYDPSTNKWSLKAAM 502
YDP ++ W A M
Sbjct: 545 KYDPISDTWLDSAGM 559
Score = 42.4 bits (98), Expect = 0.001
Identities = 24/103 (23%), Positives = 46/103 (44%), Gaps = 3/103 (2%)
Query: 366 KWVEFACVTLKNEVYISGGKE-TQH--DVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGK 422
K + F + +++ GG H + +Y+ N+W + R V+
Sbjct: 468 KRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNY 527
Query: 423 VYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATS 465
+YV+GG G +N V+ YDP + W ++A ++ +F T+
Sbjct: 528 LYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTA 570
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 244 bits (622), Expect = 2e-64
Identities = 161/560 (28%), Positives = 263/560 (46%), Gaps = 35/560 (6%)
Query: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAE 121
+E E L DV+L HR+VL+A S+YF AMF ND+ E ++ + ++GVD
Sbjct: 172 MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPN 231
Query: 122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLA 181
+++L+ Y YT + + ++ +L AA L Q +++D C++FL + L+P NC+GI
Sbjct: 232 ALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
Query: 182 DTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMS 241
D L Y +++F++++ ++EFL LP + + +L SDD+ V +E +F +M
Sbjct: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
Query: 242 WVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHL-- 299
WV H R L +L +RLPLL P + +E + E LL EA YHL
Sbjct: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLMEAMKYHLLP 410
Query: 300 -SGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEH 358
+ + S RTKPR + +GG + + D S L + +
Sbjct: 411 ERRSMMQSPRTKPRKSTVGA--LYAVGGMDA-MKGTTTIEKYDLRTNSWLHIGTM----- 462
Query: 359 ELESENKKWVEFACVTLKNEVYISGGKE---TQHDVWKYNSSINKWIQIEYLNIGRWRHK 415
N + ++F + N++Y+ GG++ T + V +N W + ++ R
Sbjct: 463 -----NGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLG 517
Query: 416 MVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGG 475
+ L G +Y +GG DG +N VE +DP W+ A + S+ + KLY I G
Sbjct: 518 VATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAI-G 576
Query: 476 GPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG-----------A 524
G +G + +DP TNKWSL A M + ++ +YVVGG
Sbjct: 577 GRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRL 636
Query: 525 MRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQ 584
+ Y P DSW V LS R + + P ++LY+ GG D + + TV +D +
Sbjct: 637 SDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYD-GHTYLNTVESYDAQRN 695
Query: 585 KLTEECVLPRGVSHHGSVTI 604
+ EE +P + G+ +
Sbjct: 696 EWKEE--VPVNIGRAGACVV 713
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 242 bits (618), Expect = 6e-64
Identities = 170/553 (30%), Positives = 266/553 (48%), Gaps = 43/553 (7%)
Query: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIK-GVDA 120
L TLR TDV L + F CHR VLAA+S YF AMF + L+E + + + +
Sbjct: 36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHP 95
Query: 121 ETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRL 180
E + LLD+ Y+S+ I ++N + +LEA ++ QF + DA A FL + L P NC+G++ L
Sbjct: 96 EVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLL 155
Query: 181 ADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVM 240
+D H L + + +F + SE+F L DTL ++ SD+L +E VFE ++
Sbjct: 156 SDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAIL 215
Query: 241 SWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEA-----R 295
WV+H R LP +L +VRL LL E V ++ L+ ++ EA R
Sbjct: 216 QWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEALRCKTR 275
Query: 296 MYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPL 355
+ G + S +PR +I+GG T + +V AK +
Sbjct: 276 ILQNDG-VVTSPCARPRK---AGHTLLILGGQTFMCDKIYQVD----------HKAKEII 321
Query: 356 TEHELESENKKWVEFACVTLKNEVYISGGKETQH----DVWKYNSSINKWIQIEYLNIGR 411
+ +L S K EF+ + +VY++GG+ +++ DVW Y++ +W + + I R
Sbjct: 322 PKADLPSPRK---EFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIAR 378
Query: 412 WRHKMVVLGGKVYVIGGFDGLQ---------RINNVETYDPFHNCWSEAAPLLVHVSSFA 462
+ H L +YV+GG L + VE YDP N W APL VS+ A
Sbjct: 379 FGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAA 438
Query: 463 ATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVG 522
S K KL+V GG + K QCYDPS N+W++KA P + A +I+++G
Sbjct: 439 VVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMG 498
Query: 523 G----AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLC 578
G + Y + + W + ++ +R SC N+LY+ GG + T+ C
Sbjct: 499 GDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGY-FGTQRCKTLDC 557
Query: 579 WDPEAQKLTEECV 591
+DP + T C+
Sbjct: 558 YDPTSD--TWNCI 568
Score = 51.6 bits (122), Expect = 2e-06
Identities = 34/149 (22%), Positives = 63/149 (42%), Gaps = 16/149 (10%)
Query: 461 FAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYV 520
F+A++ K+YV GG + + YD +WS A M + + + +YV
Sbjct: 333 FSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYV 392
Query: 521 VGG--------------AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGR 566
VGG +++ + Y P + W +V L ++ + +L++ GG
Sbjct: 393 VGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGT 452
Query: 567 DEKNEVIATVLCWDPEAQKLT--EECVLP 593
++++ V C+DP + T EC P
Sbjct: 453 SIHRDMVSKVQCYDPSENRWTIKAECPQP 481
Score = 48.1 bits (113), Expect = 2e-05
Identities = 38/138 (27%), Positives = 63/138 (45%), Gaps = 8/138 (5%)
Query: 371 ACVTLKNEVYISGGKETQHD----VWKYNSSINKWIQIEYLNIGRWRHKMV-VLGGKVYV 425
A V+ K ++++ GG D V Y+ S N+W I+ WR+ VLG ++++
Sbjct: 438 AVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWT-IKAECPQPWRYTAAAVLGSQIFI 496
Query: 426 IGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDK 485
+GG D + +D N W+ + S A + KLYV+GG G
Sbjct: 497 MGG-DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGY-FGTQRCKT 554
Query: 486 TQCYDPSTNKWSLKAAMP 503
CYDP+++ W+ +P
Sbjct: 555 LDCYDPTSDTWNCITTVP 572
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 242 bits (617), Expect = 8e-64
Identities = 157/544 (28%), Positives = 263/544 (48%), Gaps = 44/544 (8%)
Query: 84 SCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQ 143
SC R+VL++ S+YF AMF ND++E ++ I ++GV+ ++ +L+ Y YT + + + N++
Sbjct: 172 SC-RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIE 230
Query: 144 RVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQ 203
+L A L Q ++V+AC FL + L+P NC+GI AD L K +Y +++F++
Sbjct: 231 CLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFME 290
Query: 204 ILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRL 263
++ ++EF+ LP + +L SDD+ + E + +++WVRH +R L +L +RL
Sbjct: 291 VIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRL 350
Query: 264 PLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSGNE---IISERTKPRMHEFQSEV 320
PLL P F+ +E + L R E L+ EA YHL + S RTKPR +
Sbjct: 351 PLLAP-QFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTV-GTL 408
Query: 321 FMIIG-----GCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTL 375
F + G G T E++ P + + N + ++F L
Sbjct: 409 FAVGGMDSTKGATSIEKYDLRTNMWTP-----------------VANMNGRRLQFGVAVL 451
Query: 376 KNEVYISGGKE---TQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGL 432
+++Y+ GG++ T + V YN W + ++ R + VL G +Y +GG DG
Sbjct: 452 DDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGW 511
Query: 433 QRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPS 492
+N VE +DP W+ A + S+ KLY + GG +G +C+DP
Sbjct: 512 SYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAV-GGRDGSSCLKSVECFDPH 570
Query: 493 TNKWSLKAAMPVEAKCINAVSFRDRIYVVGG-----------AMRALYAYSPLEDSWCLV 541
TNKW+L A M + ++ +Y +GG + Y P D W V
Sbjct: 571 TNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAV 630
Query: 542 TQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGS 601
+S R + G+ ++LY GG D + + TV +DP+ + T+ L G +
Sbjct: 631 ASMSISRDAVGVCLLGDKLYAVGGYDGQ-AYLNTVEAYDPQTNEWTQVAPLCLGRAGACV 689
Query: 602 VTIR 605
VT++
Sbjct: 690 VTVK 693
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 241 bits (615), Expect = 1e-63
Identities = 158/544 (29%), Positives = 256/544 (47%), Gaps = 33/544 (6%)
Query: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAE 121
+E E L DV+L HR+VL+A S+YF AMF ND+ E ++ + ++GVD
Sbjct: 172 MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPN 231
Query: 122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLA 181
+++L+ Y YT + + ++ +L AA L Q +++D C++FL + L+P NC+GI
Sbjct: 232 ALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
Query: 182 DTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMS 241
D L Y +++F++++ ++EFL LP + + +L SDD+ V +E +F +M
Sbjct: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
Query: 242 WVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHL-- 299
WV H R L +L +RLPLL P + +E + E LL EA YHL
Sbjct: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLMEAMKYHLLP 410
Query: 300 -SGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEH 358
+ + S RTKPR + +GG + + D S L + +
Sbjct: 411 ERRSMMQSPRTKPRKSTVGA--LYAVGGMDA-MKGTTTIEKYDLRTNSWLHIGTM----- 462
Query: 359 ELESENKKWVEFACVTLKNEVYISGGKE---TQHDVWKYNSSINKWIQIEYLNIGRWRHK 415
N + ++F + N++Y+ GG++ T + V +N W + ++ R
Sbjct: 463 -----NGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLG 517
Query: 416 MVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGG 475
+ L G +Y +GG DG +N VE +DP W+ A + S+ + KLY I G
Sbjct: 518 VATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAI-G 576
Query: 476 GPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG-----------A 524
G +G + +DP TNKWSL A M + ++ +YVVGG
Sbjct: 577 GRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRL 636
Query: 525 MRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQ 584
+ Y P DSW V LS R + + P ++LY+ GG D + + TV +D +
Sbjct: 637 SDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYD-GHTYLNTVESYDAQRN 695
Query: 585 KLTE 588
+ E
Sbjct: 696 EWKE 699
Score = 47.0 bits (110), Expect = 5e-05
Identities = 22/61 (36%), Positives = 35/61 (57%)
Query: 391 VWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSE 450
V +Y+ + W + L++ R + LG K+YV+GG+DG +N VE+YD N W E
Sbjct: 640 VERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699
Query: 451 A 451
+
Sbjct: 700 S 700
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 240 bits (613), Expect = 2e-63
Identities = 159/551 (28%), Positives = 266/551 (48%), Gaps = 33/551 (5%)
Query: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAE 121
+E+ + L DVIL V ++ HR+VL++ S+YF AMF +D+ E ++ I ++G+D
Sbjct: 202 MESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPN 261
Query: 122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLA 181
+ L+ + YT + + ++ +L AA L Q ++V+ C FL + L+P NC+GI A
Sbjct: 262 ALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFA 321
Query: 182 DTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMS 241
D L K SY ++N ++++ ++EFL LP + LH +L SDD+ V +E +F +M
Sbjct: 322 DAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMM 381
Query: 242 WVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSG 301
WV++ R L +L +RLPLL P + +E L + E L+ EA YHL
Sbjct: 382 WVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQKLILEAMKYHLLP 440
Query: 302 NE---IISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEH 358
+ S RTKPR + +GG ++ T R+ L +
Sbjct: 441 ERRTLMQSPRTKPRKSTVGT--LYAVGGMDNNK---GATTIEKYDLRTNLWI-------- 487
Query: 359 ELESENKKWVEFACVTLKNEVYISGGKE---TQHDVWKYNSSINKWIQIEYLNIGRWRHK 415
+ N + ++F + +++++ GG++ T + V YN W + ++ R
Sbjct: 488 QAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLG 547
Query: 416 MVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGG 475
+ VL G +Y +GG DG +N VE +DP W+ A + + S+ + KLY + G
Sbjct: 548 VTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSV-G 606
Query: 476 GPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG-----------A 524
G +G + YDP TNKW++ A M + + +Y VGG
Sbjct: 607 GRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRL 666
Query: 525 MRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQ 584
+ + Y P D+W +V LS R + G+ +RLY GG D + + T+ +DP+
Sbjct: 667 LDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQT-YLNTMESYDPQTN 725
Query: 585 KLTEECVLPRG 595
+ T+ L G
Sbjct: 726 EWTQMASLNIG 736
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 239 bits (611), Expect = 4e-63
Identities = 158/547 (28%), Positives = 255/547 (46%), Gaps = 29/547 (5%)
Query: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAE 121
+ +R L D++L V +E H+VVLA+ S YF AMF N++ E + + + +D +
Sbjct: 82 MSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQ 141
Query: 122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLA 181
+ L+ + YT++ ++ + NVQ +L AA+L Q + DAC FL L+P NC+GI A
Sbjct: 142 ALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFA 201
Query: 182 DTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMS 241
D HS L K Y++Q+FV + +EEF+ LP+ + ++ SD L V E +V+ V+S
Sbjct: 202 DAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLS 261
Query: 242 WVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSG 301
WV+H R +P +++ VRLPLL + + V+A+ L+R P+ LL EA +HL
Sbjct: 262 WVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLP 321
Query: 302 NE---IISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTC-LDPLRRSRLEVAKLPLTE 357
+ + + RT+PR E V +GG F C R R
Sbjct: 322 EQRGVLGTSRTRPRRCEGAGPVLFAVGG---GSLFAIHGDCEAYDTRTDRW--------- 369
Query: 358 HELESENKKWVEFACVTLKNEVYISGGKETQHD---VWKYNSSINKWIQIEYLNIGRWRH 414
H + S + + + N +Y GG + D V Y+ N W + R
Sbjct: 370 HVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCL 429
Query: 415 KMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIG 474
+ L G +Y GG+DG +N+ E YDP W+ A + + LY +G
Sbjct: 430 GVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVG 489
Query: 475 G-GPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG-----AMRAL 528
G + LAT + Y+P N WS A+M +YV GG + ++
Sbjct: 490 GYDSSSHLAT--VEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSV 547
Query: 529 YAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQK-LT 587
YSP +W V ++ R++ + + LY GG D + + ++ ++P K +
Sbjct: 548 ERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSS-LNSIEKYNPRTNKWVA 606
Query: 588 EECVLPR 594
C+ R
Sbjct: 607 ASCMFTR 613
Score = 55.5 bits (132), Expect = 1e-07
Identities = 27/89 (30%), Positives = 47/89 (52%), Gaps = 3/89 (3%)
Query: 375 LKNEVYISGGKETQ---HDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDG 431
L+ +Y++GG + + V +Y+ W + +NI R H +V + G +Y +GG DG
Sbjct: 528 LEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDG 587
Query: 432 LQRINNVETYDPFHNCWSEAAPLLVHVSS 460
+N++E Y+P N W A+ + SS
Sbjct: 588 SSSLNSIEKYNPRTNKWVAASCMFTRRSS 616
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 235 bits (600), Expect = 8e-62
Identities = 150/517 (29%), Positives = 256/517 (49%), Gaps = 30/517 (5%)
Query: 65 LRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMH 124
LR+E L DV++ V+ EFS H+ +L + S+YFRA+F + +K I G+ + M
Sbjct: 32 LRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMK 91
Query: 125 TLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTH 184
+++Y YT IT NV+++L AA+ F + +V C FL L +NC+GI + D +
Sbjct: 92 LIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYY 151
Query: 185 SLDSLKKQVQSYIIQNFVQILN-SEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWV 243
L+++ +I+ NF +++ S EFL+L V L I++ D+L V +E VFE ++ W+
Sbjct: 152 YCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWI 211
Query: 244 RHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEA--RMYHL-- 299
H P R + +L VRL L+ YF+ V+ + ++ E P++ A MY L
Sbjct: 212 SHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNM 271
Query: 300 ---SGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLT 356
S ++ + T+PR+ + IGG + P A+
Sbjct: 272 NGPSNSDFTNPLTRPRL---PYAILFAIGGWSGG----------SPTNAIEAYDARADRW 318
Query: 357 EHELESENKKWVEFACVTLKNEVYISGGKETQ---HDVWKYNSSINKWIQIEYLNIGRWR 413
+ E LK VYI GG ++ + V +++ W Q+ ++ R
Sbjct: 319 VNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCY 378
Query: 414 HKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVI 473
+ VLG +Y +GGFDG R+N E Y+P N W+ AP+ S +AT+ K+Y+
Sbjct: 379 VSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYIC 438
Query: 474 GGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG-----AMRAL 528
GG NG + Y+ +N+W++ A M I +++ + +Y VGG +R+
Sbjct: 439 GGF-NGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSA 497
Query: 529 YAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGG 565
AYSP+ ++W + + + R++ GI ++ L++ GG
Sbjct: 498 EAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGG 534
Score = 52.0 bits (123), Expect = 2e-06
Identities = 41/202 (20%), Positives = 76/202 (37%), Gaps = 52/202 (25%)
Query: 423 VYVIGGFDGLQRINNVETYDPFHNCW-----SEAAPLLVHVSSF---------------- 461
++ IGG+ G N +E YD + W E +P H +++
Sbjct: 293 LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDY 352
Query: 462 ----------------AATSHKKKLY----VIG------GGPNGKLATDKTQCYDPSTNK 495
A H ++ Y V+G GG +G + + + Y+P TN+
Sbjct: 353 FNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQ 412
Query: 496 WSLKAAMPVEAKCINAVSFRDRIYVVGG-----AMRALYAYSPLEDSWCLVTQLSHERAS 550
W+L A M + +A + ++Y+ GG + Y+ + W ++ + R+
Sbjct: 413 WTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSG 472
Query: 551 CGIAPCNNRLYITGGRDEKNEV 572
G+ +Y GG D N +
Sbjct: 473 IGVIAYGEHVYAVGGFDGANRL 494
Score = 35.0 bits (79), Expect = 0.21
Identities = 41/170 (24%), Positives = 66/170 (38%), Gaps = 40/170 (23%)
Query: 313 MHEFQSEV--------FMIIGGCTKDE-RFVAEV--------TCLDPLRRSRLEVAKLPL 355
MHE +S+ I GG +E F AEV T + P+R R + +
Sbjct: 419 MHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAY 478
Query: 356 TEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWK---YNSSINKWIQIEYLNIGRW 412
EH VY GG + + + Y+ N W I + R
Sbjct: 479 GEH--------------------VYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRS 518
Query: 413 RHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFA 462
+ V+ ++V+GGF+G NVE YD + W +A + ++ S+ +
Sbjct: 519 NFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALS 568
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 221 bits (564), Expect = 1e-57
Identities = 177/602 (29%), Positives = 286/602 (47%), Gaps = 56/602 (9%)
Query: 22 GPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLSLILQNGLETLRMENALTDVILCVDIQ 81
GP + + K G L K F S L GL TLR + L DV+L ++ +
Sbjct: 20 GPGPERPNSTADKNGAL-------KCTFSAPSHSTSLLQGLATLRAQGQLLDVVLTINRE 72
Query: 82 EFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQN 141
F H+VVLAA S+YFRAMF ++E + I +KGV A + ++D+ Y+++ +
Sbjct: 73 AFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDC 132
Query: 142 VQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNF 201
VQ VL AA Q L +V+ C FL A++ E C+ I ++A T SL SL++ V ++ ++F
Sbjct: 133 VQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRESVDAFTFRHF 192
Query: 202 VQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENV 261
+QI E+FL LP++ L L+S+ L E +F + W++H P+ R +VL ++
Sbjct: 193 LQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHDPARR-PRASHVLCHI 251
Query: 262 RLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHL---SGNEIISERTKPRMHEFQS 318
R PL+ V++V+ ++ + L EA Y + +E+ S RT R S
Sbjct: 252 RFPLMQSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSPRTAVR-----S 306
Query: 319 EV--FMIIGGC--TKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELE-SENKKWVEFACV 373
+V + GG T +R V+ S++ P H E +E + CV
Sbjct: 307 DVPSLVTFGGTPYTDSDRSVS----------SKVYQLPEPGARHFRELTEMEVGCSHTCV 356
Query: 374 -TLKNEVYISGGKETQH--------DVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVY 424
L N VY++GG+ Q+ ++Y+ +N+W++++ + R + ++ VL G VY
Sbjct: 357 AVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVY 416
Query: 425 VIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATD 484
GG + + +VE Y P N W A L A + +LY+ GG G D
Sbjct: 417 ATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGGRLYISGG--YGISVED 474
Query: 485 K--TQCYDPSTNKWSLKAAMPVEAKCINA-VSFRDRIYVVGGAM---------RALYAYS 532
K CYDP ++W KA M E + ++A V RIY +GG M A+ Y
Sbjct: 475 KKALHCYDPVADQWEFKAPMS-EPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYV 533
Query: 533 PLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEK-NEVIATVLCWDPEAQKLTEECV 591
P D W V+ + ++ G ++YI GG + + N V V ++ + + +
Sbjct: 534 PETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTGIVQVYNTDTDEWERDLH 593
Query: 592 LP 593
P
Sbjct: 594 FP 595
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 219 bits (559), Expect = 5e-57
Identities = 151/516 (29%), Positives = 243/516 (47%), Gaps = 27/516 (5%)
Query: 105 LKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASF 164
+ E KR+ IK VD T+ L+DY YT++ +T++NVQ +L AA L Q + C F
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 165 LTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKS 224
L L+P NC+GI AD H+ L + +Y Q+F ++ SEEFL+L ++ + ++ S
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 225 DDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQC 284
D L ++ E +VFE V++WV H R + ++E+VRLPLL Y V+ VE + L++
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
Query: 285 PEVFPLLQEARMYHLSGNE----IISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCL 340
L EA YHL E + S RT+ R ++ +++GG + + + V C
Sbjct: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG--QAPKAIRSVECY 238
Query: 341 DPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQ---HDVWKYNSS 397
D +VA+LP + V + V+ GG V Y+
Sbjct: 239 DFKEERWHQVAELP----------SRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPV 288
Query: 398 INKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVH 457
++W + + R VL G +Y +GGFDG +++VE Y+ N W AP+
Sbjct: 289 KDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTR 348
Query: 458 VSSFAATSHKKKLYVIGGGPN-GKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRD 516
SS LY +GG + +CY+ +TN+W+ A M +
Sbjct: 349 RSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNN 408
Query: 517 RIYVVGG-----AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNE 571
+Y VGG +++ Y P ++W V ++ R + G+ N LY+ GG D+ +
Sbjct: 409 LLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSC 467
Query: 572 VIATVLCWDPEAQKLT-EECVLPRGVSHHGSVTIRK 606
+A+V ++P K T + G S+ G I K
Sbjct: 468 NLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDK 503
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 218 bits (554), Expect = 2e-56
Identities = 156/561 (27%), Positives = 269/561 (47%), Gaps = 29/561 (5%)
Query: 55 SLILQNGLETLRMENALTDVILCVDIQE--FSCHRVVLAAASNYFRAMFCNDLKEKYEKR 112
S++LQ G + LR+E L DV L + F HRV++A+AS+YF+AMF +KE+
Sbjct: 76 SVVLQ-GFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMC 134
Query: 113 IIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPE 172
I + GV + ++D+ YT+K + N+Q LEAA+ Q L ++D C FL + +
Sbjct: 135 IKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLD 194
Query: 173 NCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEE 232
NCV + R+A+T++L + K V S++++NF +L++ EFL LP + L +L S+ L E
Sbjct: 195 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTE 254
Query: 233 AQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQ 292
++F+ W+R + R+ +++N+R PL+ P + V+ +R LL
Sbjct: 255 LELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLL 313
Query: 293 EARMYHL---SGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVA-EVTCLDPLRRSRL 348
EA Y + + S+RT R + + +GG + + V+ E+ D
Sbjct: 314 EASNYQMMPYMQPVMQSDRTAIRS---DTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWK 370
Query: 349 EVAKL--PLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEY 406
+A + P +H + F V Y + GK V++++ NKW+Q+
Sbjct: 371 SLAPMDAPRYQHGIAVIG----NFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVAS 426
Query: 407 LNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSH 466
LN R + L G +Y +GG + + VE Y+P N W+ A + A T +
Sbjct: 427 LNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVY 486
Query: 467 KKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG--- 523
+Y+ GG + + C+DP T+KW KA M + +R+YV+GG
Sbjct: 487 GGVMYISGGITHDTFQKE-LMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHF 545
Query: 524 -------AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNE-VIAT 575
+ + YSP+ D W + + ++ G+A N++Y+ GG N ++
Sbjct: 546 RGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEI 605
Query: 576 VLCWDPEAQKLTEECVLPRGV 596
V +DP+ + + LP +
Sbjct: 606 VQKYDPDKDEWHKVFDLPESL 626
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 217 bits (553), Expect = 2e-56
Identities = 159/561 (28%), Positives = 269/561 (47%), Gaps = 29/561 (5%)
Query: 55 SLILQNGLETLRMENALTDVILCVDIQE--FSCHRVVLAAASNYFRAMFCNDLKEKYEKR 112
S++LQ G + LR+E L DV L + F HR ++A+AS+YF+AMF +KE+
Sbjct: 34 SVVLQ-GFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLMC 92
Query: 113 IIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPE 172
I + GV+ + ++D+ YT+K + N+Q LEAA+ Q L ++D C FL ++ +
Sbjct: 93 IKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLD 152
Query: 173 NCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEE 232
NCV + R+A+T++L + K V ++I++NF +L++ EFL LP + L +L S+ L E
Sbjct: 153 NCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTE 212
Query: 233 AQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQ 292
++F+ W+R + R+ +++N+R PL+ P + V+ +R LL
Sbjct: 213 LELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLL 271
Query: 293 EARMYHL---SGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVA-EVTCLDPLRRSRL 348
EA Y + + S+RT R S + +GG + + V+ E+ D +
Sbjct: 272 EASNYQMMPYMQPVMQSDRTAIRS---DSTHLVTLGGVLRQQLVVSKELRMYDERAQEWR 328
Query: 349 EVAKL--PLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEY 406
+A + P +H + F V Y + GK V++++ NKW+Q+
Sbjct: 329 SLAPMDAPRYQHGIAVIG----NFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVAS 384
Query: 407 LNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSH 466
LN R + L G +Y +GG + VE Y+P N WS A + A T +
Sbjct: 385 LNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVY 444
Query: 467 KKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG--- 523
+Y I GG ++ C+DP T+KW KA M + D++YV+GG
Sbjct: 445 GGLMY-ISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHF 503
Query: 524 -------AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNE-VIAT 575
+ + YSP D W + + ++ G+A N++Y+ GG N ++
Sbjct: 504 RGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEI 563
Query: 576 VLCWDPEAQKLTEECVLPRGV 596
V +DPE + + LP +
Sbjct: 564 VQKYDPEKDEWHKVFDLPESL 584
>gi|227497736 T-cell activation kelch repeat protein [Homo sapiens]
Length = 601
Score = 216 bits (551), Expect = 4e-56
Identities = 148/482 (30%), Positives = 232/482 (48%), Gaps = 52/482 (10%)
Query: 62 LETLRMENALTDVILCVDI-QEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDA 120
L+T+ E LTD+++ VD + FSCHR VLAA S YFR+MF + L E +K + I GV+A
Sbjct: 39 LKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEA 98
Query: 121 ETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRL 180
E+M +L+Y YTS+ ++T+ NVQ + AA++FQ + D CA ++ L+P+N +G+
Sbjct: 99 ESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIF 158
Query: 181 ADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVM 240
AD + L + + YI + F+ + +EFL L D L IL SDDL V E V+E+++
Sbjct: 159 ADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESII 218
Query: 241 SWVRHKPSERLCLLPYVLEN-VRLPLLDPWYFVETVE---ADPLIRQCPEVFPLLQEARM 296
W H+ +ER LP + +R PL++ F+E + A + + C E P
Sbjct: 219 RWFEHEQNEREVHLPEIFAKCIRFPLMED-TFIEKIPPQFAQAIAKSCVEKGP------- 270
Query: 297 YHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLT 356
+ R+ SE+ + K V CLD + ++ K P
Sbjct: 271 -------SNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPND 323
Query: 357 EHELESENKKWVEFACVTLKNEVYISGG-----------KETQHDVWKYNSSINKWIQIE 405
E+ V+ N++YI+GG + ++D W Y+ S N+W+
Sbjct: 324 LREVG---------ILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKP 374
Query: 406 YLNIGRWRHKMVVLGGKVYVIGG----FDGLQRINNVETYDPFHNCWSEAAPLLVHVSSF 461
L R K+V GK+Y IGG DG + +VE YD NCW+ + V +
Sbjct: 375 SLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFH 434
Query: 462 AATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVV 521
A +K+K+YV+ G + Y+P + W M V A ++D IY +
Sbjct: 435 NAVEYKEKIYVLQG--------EFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYI 486
Query: 522 GG 523
G
Sbjct: 487 AG 488
Score = 36.6 bits (83), Expect = 0.071
Identities = 27/112 (24%), Positives = 43/112 (38%), Gaps = 18/112 (16%)
Query: 512 VSFRDRIYVVGG-------------AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNN 558
VS + IY+ GG A + Y + W L R C + C
Sbjct: 331 VSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCG 390
Query: 559 RLYITGGR----DEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTIRK 606
++Y GGR D +N + +V C+D T C +P + H +V ++
Sbjct: 391 KMYAIGGRVYEGDGRNS-LKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKE 441
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,077,097
Number of Sequences: 37866
Number of extensions: 997376
Number of successful extensions: 3429
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 161
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 2236
Number of HSP's gapped (non-prelim): 379
length of query: 621
length of database: 18,247,518
effective HSP length: 108
effective length of query: 513
effective length of database: 14,157,990
effective search space: 7263048870
effective search space used: 7263048870
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.