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Search of human proteins with 4557485
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557485 ceruloplasmin precursor [Homo sapiens]
(1065 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557485 ceruloplasmin precursor [Homo sapiens] 2235 0.0
gi|148886707 hephaestin-like 1 [Homo sapiens] 1117 0.0
gi|195963313 hephaestin isoform a [Homo sapiens] 1071 0.0
gi|195947365 hephaestin isoform c [Homo sapiens] 1071 0.0
gi|7662254 hephaestin isoform b [Homo sapiens] 830 0.0
gi|4503647 coagulation factor VIII isoform a precursor [Homo sap... 426 e-119
gi|105990535 coagulation factor V precursor [Homo sapiens] 399 e-111
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 35 0.38
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 33 1.1
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 33 1.1
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 33 1.1
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 33 1.1
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 33 1.1
gi|215490104 calpain 11 [Homo sapiens] 33 1.9
gi|122937436 tetratricopeptide repeat domain 39A isoform 2 [Homo... 32 3.2
gi|221307588 tetratricopeptide repeat domain 39A isoform 1 [Homo... 32 3.2
gi|237820624 pleckstrin homology domain containing, family N mem... 31 7.1
gi|237820622 pleckstrin homology domain containing, family N mem... 31 7.1
>gi|4557485 ceruloplasmin precursor [Homo sapiens]
Length = 1065
Score = 2235 bits (5792), Expect = 0.0
Identities = 1065/1065 (100%), Positives = 1065/1065 (100%)
Query: 1 MKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGP 60
MKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGP
Sbjct: 1 MKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGP 60
Query: 61 DRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFH 120
DRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFH
Sbjct: 61 DRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFH 120
Query: 121 SHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYH 180
SHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYH
Sbjct: 121 SHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYH 180
Query: 181 SHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYC 240
SHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYC
Sbjct: 181 SHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYC 240
Query: 241 SEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFH 300
SEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFH
Sbjct: 241 SEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFH 300
Query: 301 GQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKS 360
GQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKS
Sbjct: 301 GQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKS 360
Query: 361 SSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSY 420
SSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSY
Sbjct: 361 SSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSY 420
Query: 421 KKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGV 480
KKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGV
Sbjct: 421 KKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGV 480
Query: 481 RFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYY 540
RFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYY
Sbjct: 481 RFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYY 540
Query: 541 SAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMF 600
SAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMF
Sbjct: 541 SAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMF 600
Query: 601 TTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYF 660
TTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYF
Sbjct: 601 TTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYF 660
Query: 661 SGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRR 720
SGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRR
Sbjct: 661 SGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRR 720
Query: 721 QSEDSTFYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYK 780
QSEDSTFYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYK
Sbjct: 721 QSEDSTFYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYK 780
Query: 781 KVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQ 840
KVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQ
Sbjct: 781 KVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQ 840
Query: 841 TESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVC 900
TESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVC
Sbjct: 841 TESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVC 900
Query: 901 RRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHA 960
RRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHA
Sbjct: 901 RRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHA 960
Query: 961 INGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFP 1020
INGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFP
Sbjct: 961 INGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFP 1020
Query: 1021 GTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNEDTKSG 1065
GTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNEDTKSG
Sbjct: 1021 GTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNEDTKSG 1065
>gi|148886707 hephaestin-like 1 [Homo sapiens]
Length = 1159
Score = 1117 bits (2890), Expect = 0.0
Identities = 546/1054 (51%), Positives = 716/1054 (67%), Gaps = 24/1054 (2%)
Query: 24 YYIGIIETTWDYASDHGEKKLIS----VDTEHSNIYLQNGPDRIGRLYKKALYLQYTDET 79
YYIGI+E W+Y K +I+ + + + ++L+ GP+RIG +YKKA+Y ++TD T
Sbjct: 29 YYIGIVEEYWNYVPQG--KNVITGKSFTEDKLATLFLERGPNRIGSIYKKAVYRRFTDGT 86
Query: 80 FRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNT 139
+ I KP WLGFLGPI++AE GD + +HLKN ASRPY+ H HG+ Y K+ EGA+YPD T
Sbjct: 87 YSIEIPKPPWLGFLGPILRAEVGDVIVIHLKNFASRPYSLHPHGVFYNKDSEGALYPDGT 146
Query: 140 TDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLII 199
+ + DD V PG+ YTY+ EE +P D NC+T +YHSHIDAPKDI SGLIGPL++
Sbjct: 147 SGRNKNDDMVPPGKNYTYVWPVREEYAPTPADANCLTWVYHSHIDAPKDICSGLIGPLLV 206
Query: 200 CKKDSLDKEK--EKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESN 257
CK+ L++ +DREFV+MF++VDEN SWYL +NIK +C+ P+ VDK + FQ SN
Sbjct: 207 CKEGILNRYSGTRNDVDREFVIMFTLVDENQSWYLNENIKHFCTNPDSVDKKDAVFQRSN 266
Query: 258 RMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLF 317
+M+++NGY FG+ P MC + V W+LFGMGNE+D+H+ +F+G ++ +R D +NLF
Sbjct: 267 KMHALNGYLFGNFPEPDMCVGESVSWHLFGMGNEIDIHSIYFYGNTFISRGHRTDVVNLF 326
Query: 318 PATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGKHVRHYYIA 377
PAT M+A+NPG+WM++CQ +HL+AG+ + V C ++G+ R Y+IA
Sbjct: 327 PATFLTTEMIAENPGKWMITCQVSDHLQAGMLGQYNVDNCKSDIFYPKMKGQQ-RRYFIA 385
Query: 378 AEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNRK 437
AE+I+W+YAP G + F+ L A GSDS ++F QG RIGG Y K+ Y E+ DA+FT RK
Sbjct: 386 AEKILWDYAPQGYNKFSGLPLNASGSDSDLYFTQGDNRIGGKYWKVRYTEFVDATFTKRK 445
Query: 438 ERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNP 497
EE HLGILGPVI AEVGDT+ VTF NK SI P GV ++K ++ +PN +
Sbjct: 446 RLSAEEAHLGILGPVIKAEVGDTLLVTFANKADKVYSILPHGVIYDKASDA---APNLDG 502
Query: 498 QSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFTGLIGPM 557
V P A HV P ETFTY+WTVP+ V PT DP CL +Y+SAVDP KD +GL+GP+
Sbjct: 503 ---FVKPGA-HVKPGETFTYKWTVPESVSPTAGDPPCLTYLYFSAVDPIKDTSSGLVGPL 558
Query: 558 KICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQES 617
+CKKG L+A+G QK +DKEFYL TVFDEN S ++NI+ F P +DKED++F +S
Sbjct: 559 LVCKKGVLNADGTQKGIDKEFYLLFTVFDENLSRYFDENIQKFIWHPFSIDKEDKEFVKS 618
Query: 618 NKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTANL 677
N+MH++NG+MYGNQPGL MCK D V W+L G + D+HGI F GNT RG RD+ L
Sbjct: 619 NRMHAVNGYMYGNQPGLNMCKRDRVSWHLIGLGTDTDMHGIVFQGNTIHLRGTHRDSLAL 678
Query: 678 FPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDSTFYLGERTYYIA 737
FP + T M PD G F V C T H + GM Q Y V+ C + Y RT+YIA
Sbjct: 679 FPHMATTAFMQPDHAGIFRVFCATMPHLSRGMGQIYEVSSCDNRDPSEQRYGMIRTFYIA 738
Query: 738 AVEVEWDYSPQREWEKELHHL--QEQNVSNAFLDKGEFYIGSKYKKVVYRQYTDSTFRVP 795
A EVEWDY+P + WE E H+ + + + F+++ E +IGS+YKKVVYR+YTD F
Sbjct: 739 AEEVEWDYAPNKNWEFEKQHVDARGERHGDIFMNRTENWIGSQYKKVVYREYTDGEFVEI 798
Query: 796 VERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTESS----TVTPTLP 851
R EEHL +LGP +HA+VG+ V IIFKN A+RPYSI A GV+ S V T P
Sbjct: 799 KARPPREEHLELLGPMIHAEVGNTVLIIFKNKASRPYSISAQGVEEMDSGKQFQVPMTKP 858
Query: 852 GETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFNPR 911
GE TY W IP+RSG G D CIPW YYSTV+ VKD YSGL+GPLI CR+ L R
Sbjct: 859 GEVKTYRWNIPKRSGPGPSDPNCIPWVYYSTVNFVKDTYSGLMGPLITCRKGVLNEKGRR 918
Query: 912 RKL--EFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNL 969
+ EFALLFLVF+ENESWYLDDNIK Y + + K ++F ESN+MHAING++FGNL
Sbjct: 919 SDVDYEFALLFLVFNENESWYLDDNIKKYLNKDPRDFKRTDDFEESNRMHAINGKIFGNL 978
Query: 970 QGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMF 1029
GL M+ NWYL+G+G+E+D+HT+H+H SF +K Y DV+D+FPGT+QT+E+F
Sbjct: 979 HGLIMNEDTMTNWYLLGIGSEVDIHTIHYHAESFLFKIDKSYREDVYDLFPGTFQTIELF 1038
Query: 1030 PRTPGIWLLHCHVTDHIHAGMETTYTVLQNEDTK 1063
PG WLLHCHV+DHIHAGMETTYTVL+N D +
Sbjct: 1039 ADHPGTWLLHCHVSDHIHAGMETTYTVLRNIDNR 1072
Score = 529 bits (1362), Expect = e-150
Identities = 287/705 (40%), Positives = 408/705 (57%), Gaps = 27/705 (3%)
Query: 368 GKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYRE 427
G R YYI E WNY P G ++ T ++ T + +F E+G RIG YKK VYR
Sbjct: 23 GTVTRTYYIGIVEEYWNYVPQGKNVITGKSFT-EDKLATLFLERGPNRIGSIYKKAVYRR 81
Query: 428 YTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNE 487
+TD +++ P+ LG LGP++ AEVGD I + N + P S+ P GV +NK++E
Sbjct: 82 FTDGTYSIEI---PKPPWLGFLGPILRAEVGDVIVIHLKNFASRPYSLHPHGVFYNKDSE 138
Query: 488 GTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTK 547
G Y + +++ + V P + +TY W V +E PT AD CL +Y+S +D K
Sbjct: 139 GALYPDGTSGRNK----NDDMVPPGKNYTYVWPVREEYAPTPADANCLTWVYHSHIDAPK 194
Query: 548 DIFTGLIGPMKICKKGSLHA-NGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQ 606
DI +GLIGP+ +CK+G L+ +G + DVD+EF + T+ DEN+S L +NI+ F T PD
Sbjct: 195 DICSGLIGPLLVCKEGILNRYSGTRNDVDREFVIMFTLVDENQSWYLNENIKHFCTNPDS 254
Query: 607 VDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYL 666
VDK+D FQ SNKMH++NG+++GN P MC G+SV W+LF GNE D+H IYF GNT++
Sbjct: 255 VDKKDAVFQRSNKMHALNGYLFGNFPEPDMCVGESVSWHLFGMGNEIDIHSIYFYGNTFI 314
Query: 667 WRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDST 726
RG R D NLFP T LT M + G + + C +DH GM +Y V+ C+
Sbjct: 315 SRGHRTDVVNLFPATFLTTEMIAENPGKWMITCQVSDHLQAGMLGQYNVDNCKSDIFYPK 374
Query: 727 FYLGERTYYIAAVEVEWDYSPQREWE-KELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYR 785
+R Y+IAA ++ WDY+PQ + L + S+ + +G+ IG KY KV Y
Sbjct: 375 MKGQQRRYFIAAEKILWDYAPQGYNKFSGLPLNASGSDSDLYFTQGDNRIGGKYWKVRYT 434
Query: 786 QYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGV-QTESS 844
++ D+TF AEE HLGILGP + A+VGD + + F N A + YSI HGV ++S
Sbjct: 435 EFVDATFTKRKRLSAEEAHLGILGPVIKAEVGDTLLVTFANKADKVYSILPHGVIYDKAS 494
Query: 845 TVTPTL-----------PGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGL 893
P L PGET TY W +PE D C+ + Y+S VD +KD SGL
Sbjct: 495 DAAPNLDGFVKPGAHVKPGETFTYKWTVPESVSPTAGDPPCLTYLYFSAVDPIKDTSSGL 554
Query: 894 IGPLIVCRRPYLKVFNPRRKL--EFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEE 951
+GPL+VC++ L ++ + EF LLF VFDEN S Y D+NI+ + HP ++K+D+E
Sbjct: 555 VGPLLVCKKGVLNADGTQKGIDKEFYLLFTVFDENLSRYFDENIQKFIWHPFSIDKEDKE 614
Query: 952 FIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVY 1011
F++SN+MHA+NG M+GN GL M D V+W+L+G+G + D+H + F G++ RG +
Sbjct: 615 FVKSNRMHAVNGYMYGNQPGLNMCKRDRVSWHLIGLGTDTDMHGIVFQGNTIHL--RGTH 672
Query: 1012 SSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTV 1056
D +FP T M P GI+ + C H+ GM Y V
Sbjct: 673 -RDSLALFPHMATTAFMQPDHAGIFRVFCATMPHLSRGMGQIYEV 716
Score = 499 bits (1285), Expect = e-141
Identities = 269/708 (37%), Positives = 400/708 (56%), Gaps = 32/708 (4%)
Query: 20 KEKHYYIGIIETTWDYASDHGEKKL----ISVDTEHSNIYLQNGPDRIGRLYKKALYLQY 75
+++ Y+I + WDYA G K ++ S++Y G +RIG Y K Y ++
Sbjct: 378 QQRRYFIAAEKILWDYA-PQGYNKFSGLPLNASGSDSDLYFTQGDNRIGGKYWKVRYTEF 436
Query: 76 TDETF---RTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEG 132
D TF + + LG LGP+IKAE GD + V N A + Y+ HG+ Y K +
Sbjct: 437 VDATFTKRKRLSAEEAHLGILGPVIKAEVGDTLLVTFANKADKVYSILPHGVIYDKASDA 496
Query: 133 AIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASG 192
A N F + V PGE +TY E SP GD C+T +Y S +D KD +SG
Sbjct: 497 A---PNLDGFVKPGAHVKPGETFTYKWTVPESVSPTAGDPPCLTYLYFSAVDPIKDTSSG 553
Query: 193 LIGPLIICKKDSLDKE-KEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNE 251
L+GPL++CKK L+ + +K ID+EF ++F+V DEN S Y ++NI+ + P +DK+++
Sbjct: 554 LVGPLLVCKKGVLNADGTQKGIDKEFYLLFTVFDENLSRYFDENIQKFIWHPFSIDKEDK 613
Query: 252 DFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRI 311
+F +SNRM++VNGY +G+ PGL+MC DRV W+L G+G + D+H F G + +
Sbjct: 614 EFVKSNRMHAVNGYMYGNQPGLNMCKRDRVSWHLIGLGTDTDMHGIVFQGNTIHLRGTHR 673
Query: 312 DTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGKHV 371
D++ LFP A+M + G + + C + HL G+ ++V C+ + G +
Sbjct: 674 DSLALFPHMATTAFMQPDHAGIFRVFCATMPHLSRGMGQIYEVSSCDNRDPSEQRYGM-I 732
Query: 372 RHYYIAAEEIIWNYAPSGIDIFTKENLTAPGS-DSAVFFEQGTTRIGGSYKKLVYREYTD 430
R +YIAAEE+ W+YAP+ F K+++ A G +F + IG YKK+VYREYTD
Sbjct: 733 RTFYIAAEEVEWDYAPNKNWEFEKQHVDARGERHGDIFMNRTENWIGSQYKKVVYREYTD 792
Query: 431 ASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTY 490
F K R P EEHL +LGP+I AEVG+T+ + F NK + P SI GV + + G
Sbjct: 793 GEFVEIKARPPREEHLELLGPMIHAEVGNTVLIIFKNKASRPYSISAQGV--EEMDSGKQ 850
Query: 491 YSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIF 550
+ VP + P E TY W +PK GP +DP C+ +YYS V+ KD +
Sbjct: 851 F---------QVPMT----KPGEVKTYRWNIPKRSGPGPSDPNCIPWVYYSTVNFVKDTY 897
Query: 551 TGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKE 610
+GL+GP+ C+KG L+ GR+ DVD EF L VF+ENES L+DNI+ + + K
Sbjct: 898 SGLMGPLITCRKGVLNEKGRRSDVDYEFALLFLVFNENESWYLDDNIKKYLNKDPRDFKR 957
Query: 611 DEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLW--- 667
+DF+ESN+MH++NG ++GN GL M + WYL G+E D+H I++ ++L+
Sbjct: 958 TDDFEESNRMHAINGKIFGNLHGLIMNEDTMTNWYLLGIGSEVDIHTIHYHAESFLFKID 1017
Query: 668 RGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTV 715
+ R D +LFP T T+ ++ D GT+ + C +DH GM+ YTV
Sbjct: 1018 KSYREDVYDLFPGTFQTIELFADHPGTWLLHCHVSDHIHAGMETTYTV 1065
>gi|195963313 hephaestin isoform a [Homo sapiens]
Length = 1161
Score = 1071 bits (2769), Expect = 0.0
Identities = 517/1052 (49%), Positives = 702/1052 (66%), Gaps = 26/1052 (2%)
Query: 24 YYIGIIETTWDYASDHGEKKLISVDTEHSNI----YLQNGPDRIGRLYKKALYLQYTDET 79
YY+GI + W+YA + +I+ S+I +L++ +RIG YKK +Y +Y D++
Sbjct: 31 YYLGIRDVQWNYAPKG--RNVITNQPLDSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDS 88
Query: 80 FRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNT 139
+ + +P WLGFLGP+++AE GD + +HLKN A+RPYT H HG+ Y K+ EG++YPD +
Sbjct: 89 YTDEVAQPAWLGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGS 148
Query: 140 TDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLII 199
+ +ADD V PG + Y E +P + D C+T IYHSH+DAP+DIA+GLIGPLI
Sbjct: 149 SGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLIT 208
Query: 200 CKKDSLDKE---KEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQES 256
CK+ +LD + + +D +F ++FSVVDEN SW+L +NI TYCS+P VDK++E FQES
Sbjct: 209 CKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQES 268
Query: 257 NRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINL 316
NRM+++NG+ FG+LP L+MCA+ RV W+LFGMGNE+DVH AFFHGQ LT + + D N+
Sbjct: 269 NRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANI 328
Query: 317 FPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGKHVRHYYI 376
FPAT A MV PG W++SCQ +H + G+QA ++V+ C+ + D + GK VR Y+I
Sbjct: 329 FPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGK-VRQYFI 387
Query: 377 AAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNR 436
A EI W+Y P G D T +NL PGS S FF++ ++RIGG+Y K+ Y + D +F
Sbjct: 388 EAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETF-QE 446
Query: 437 KERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYN 496
K E+ HLGILGPVI AEVGDTI+V F+N+ + P S++P GV + K+ EGT Y+
Sbjct: 447 KMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYN---- 502
Query: 497 PQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFTGLIGP 556
S P + P E TY WTVP GPT DP CL MY+SA DP +D +GL+GP
Sbjct: 503 -DGSSYPGLVA--KPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGP 559
Query: 557 MKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQE 616
+ +C+ G+L A+G+QK VDKEF+L TV DEN+S N + ++ E FQ+
Sbjct: 560 LLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQD 619
Query: 617 SNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTAN 676
SN+MH++NGF++ N P L MCKGD+V W+L G E DVHG+ F GNT +G R+ A
Sbjct: 620 SNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAM 679
Query: 677 LFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQC-RRQSEDSTFYLGERTYY 735
LFP T + M PD GTF + C H GM+ Y V+QC Q+ Y R YY
Sbjct: 680 LFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYY 739
Query: 736 IAAVEVEWDYSPQREWEKELHHLQEQ-NVSNAFLDKGEFYIGSKYKKVVYRQYTDSTFRV 794
I A EVEWDY P R WE+E H+ E+ + FL + +GS+YKK V+R+YTD TFR+
Sbjct: 740 IMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRI 799
Query: 795 PVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTESSTVTPTL--PG 852
P R EEHLGILGP + +VGD + ++FKN A+RPYS+HAHGV ES+TV P PG
Sbjct: 800 PRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGV-LESTTVWPLAAEPG 858
Query: 853 ETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFNPRR 912
E +TY W IPERSG G DSAC+ W YYS VD +KD+YSGL+GPL +C++ L+ R
Sbjct: 859 EVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRS 918
Query: 913 KL--EFALLFLVFDENESWYLDDNIKTY-SDHPEKVNKDDEEFIESNKMHAINGRMFGNL 969
+ EFALLFL+FDEN+SWYL++N+ T+ S P +N DE F+ESNKMHAING+++ NL
Sbjct: 919 DMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANL 978
Query: 970 QGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMF 1029
+GLTM+ G+ V WY++ MG ++DLHT+HFH SF Y++ Y +DV D+FPGT++ +EM
Sbjct: 979 RGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMV 1038
Query: 1030 PRTPGIWLLHCHVTDHIHAGMETTYTVLQNED 1061
PG WL+HCHVTDH+HAGMET +TV +
Sbjct: 1039 ASNPGTWLMHCHVTDHVHAGMETLFTVFSRTE 1070
Score = 500 bits (1287), Expect = e-141
Identities = 279/707 (39%), Positives = 393/707 (55%), Gaps = 35/707 (4%)
Query: 372 RHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDA 431
R YY+ ++ WNYAP G ++ T + L + S+ F + RIGG+YKK +Y+EY D
Sbjct: 29 RVYYLGIRDVQWNYAPKGRNVITNQPLDSDIVASS-FLKSDKNRIGGTYKKTIYKEYKDD 87
Query: 432 SFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYY 491
S+T + + LG LGPV+ AEVGD I + N P +I P GV + K++EG+ Y
Sbjct: 88 SYT---DEVAQPAWLGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLY 144
Query: 492 SPNYNPQSR---SVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKD 548
+ + SVPP SH+ Y WT+P+ PT+ADP CL +Y+S VD +D
Sbjct: 145 PDGSSGPLKADDSVPPGGSHI-------YNWTIPEGHAPTDADPACLTWIYHSHVDAPRD 197
Query: 549 IFTGLIGPMKICKKGSLHANG--RQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQ 606
I TGLIGP+ CK+G+L N +++DVD +F+L +V DEN S L +NI + + P
Sbjct: 198 IATGLIGPLITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPAS 257
Query: 607 VDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYL 666
VDKEDE FQESN+MH++NGF++GN P L MC V W+LF GNE DVH +F G
Sbjct: 258 VDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLT 317
Query: 667 WRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDST 726
RG D AN+FP T +T M P GT+ + C H+ GM+ Y V C
Sbjct: 318 TRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDL 377
Query: 727 FYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQ-NVSNAFLDKGEFYIGSKYKKVVYR 785
R Y+I A E++WDY P +L+E ++S+ F K IG Y KV Y
Sbjct: 378 LTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYE 437
Query: 786 QYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTE--- 842
+ D TF+ + + E+ HLGILGP + A+VGD ++++F N A++P+S+ HGV E
Sbjct: 438 AFQDETFQEKMHLE-EDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDY 496
Query: 843 ------SSTVTPTL---PGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGL 893
+ P L P E +TY W +P +G +D AC+ W Y+S D ++D SGL
Sbjct: 497 EGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGL 556
Query: 894 IGPLIVCRRPYLKVFNPRRKL--EFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEE 951
+GPL+VCR L ++ + EF LLF V DEN+SWY + N +++D E
Sbjct: 557 VGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEG 616
Query: 952 FIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVY 1011
F +SN+MHAING +F NL L M GD V W+L+G+G E D+H V F G++ Q +G+
Sbjct: 617 FQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQL--QGMR 674
Query: 1012 SSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQ 1058
+FP T+ M P G + ++C H AGM Y V Q
Sbjct: 675 KGAAM-LFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ 720
>gi|195947365 hephaestin isoform c [Homo sapiens]
Length = 1160
Score = 1071 bits (2769), Expect = 0.0
Identities = 517/1052 (49%), Positives = 702/1052 (66%), Gaps = 26/1052 (2%)
Query: 24 YYIGIIETTWDYASDHGEKKLISVDTEHSNI----YLQNGPDRIGRLYKKALYLQYTDET 79
YY+GI + W+YA + +I+ S+I +L++ +RIG YKK +Y +Y D++
Sbjct: 31 YYLGIRDVQWNYAPKG--RNVITNQPLDSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDS 88
Query: 80 FRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNT 139
+ + +P WLGFLGP+++AE GD + +HLKN A+RPYT H HG+ Y K+ EG++YPD +
Sbjct: 89 YTDEVAQPAWLGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGS 148
Query: 140 TDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLII 199
+ +ADD V PG + Y E +P + D C+T IYHSH+DAP+DIA+GLIGPLI
Sbjct: 149 SGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLIT 208
Query: 200 CKKDSLDKE---KEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQES 256
CK+ +LD + + +D +F ++FSVVDEN SW+L +NI TYCS+P VDK++E FQES
Sbjct: 209 CKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQES 268
Query: 257 NRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINL 316
NRM+++NG+ FG+LP L+MCA+ RV W+LFGMGNE+DVH AFFHGQ LT + + D N+
Sbjct: 269 NRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANI 328
Query: 317 FPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGKHVRHYYI 376
FPAT A MV PG W++SCQ +H + G+QA ++V+ C+ + D + GK VR Y+I
Sbjct: 329 FPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGK-VRQYFI 387
Query: 377 AAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNR 436
A EI W+Y P G D T +NL PGS S FF++ ++RIGG+Y K+ Y + D +F
Sbjct: 388 EAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETF-QE 446
Query: 437 KERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYN 496
K E+ HLGILGPVI AEVGDTI+V F+N+ + P S++P GV + K+ EGT Y+
Sbjct: 447 KMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYN---- 502
Query: 497 PQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFTGLIGP 556
S P + P E TY WTVP GPT DP CL MY+SA DP +D +GL+GP
Sbjct: 503 -DGSSYPGLVA--KPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGP 559
Query: 557 MKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQE 616
+ +C+ G+L A+G+QK VDKEF+L TV DEN+S N + ++ E FQ+
Sbjct: 560 LLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQD 619
Query: 617 SNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTAN 676
SN+MH++NGF++ N P L MCKGD+V W+L G E DVHG+ F GNT +G R+ A
Sbjct: 620 SNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAM 679
Query: 677 LFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQC-RRQSEDSTFYLGERTYY 735
LFP T + M PD GTF + C H GM+ Y V+QC Q+ Y R YY
Sbjct: 680 LFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYY 739
Query: 736 IAAVEVEWDYSPQREWEKELHHLQEQ-NVSNAFLDKGEFYIGSKYKKVVYRQYTDSTFRV 794
I A EVEWDY P R WE+E H+ E+ + FL + +GS+YKK V+R+YTD TFR+
Sbjct: 740 IMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRI 799
Query: 795 PVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTESSTVTPTL--PG 852
P R EEHLGILGP + +VGD + ++FKN A+RPYS+HAHGV ES+TV P PG
Sbjct: 800 PRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGV-LESTTVWPLAAEPG 858
Query: 853 ETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFNPRR 912
E +TY W IPERSG G DSAC+ W YYS VD +KD+YSGL+GPL +C++ L+ R
Sbjct: 859 EVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRS 918
Query: 913 KL--EFALLFLVFDENESWYLDDNIKTY-SDHPEKVNKDDEEFIESNKMHAINGRMFGNL 969
+ EFALLFL+FDEN+SWYL++N+ T+ S P +N DE F+ESNKMHAING+++ NL
Sbjct: 919 DMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANL 978
Query: 970 QGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMF 1029
+GLTM+ G+ V WY++ MG ++DLHT+HFH SF Y++ Y +DV D+FPGT++ +EM
Sbjct: 979 RGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMV 1038
Query: 1030 PRTPGIWLLHCHVTDHIHAGMETTYTVLQNED 1061
PG WL+HCHVTDH+HAGMET +TV +
Sbjct: 1039 ASNPGTWLMHCHVTDHVHAGMETLFTVFSRTE 1070
Score = 500 bits (1287), Expect = e-141
Identities = 279/707 (39%), Positives = 393/707 (55%), Gaps = 35/707 (4%)
Query: 372 RHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDA 431
R YY+ ++ WNYAP G ++ T + L + S+ F + RIGG+YKK +Y+EY D
Sbjct: 29 RVYYLGIRDVQWNYAPKGRNVITNQPLDSDIVASS-FLKSDKNRIGGTYKKTIYKEYKDD 87
Query: 432 SFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYY 491
S+T + + LG LGPV+ AEVGD I + N P +I P GV + K++EG+ Y
Sbjct: 88 SYT---DEVAQPAWLGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLY 144
Query: 492 SPNYNPQSR---SVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKD 548
+ + SVPP SH+ Y WT+P+ PT+ADP CL +Y+S VD +D
Sbjct: 145 PDGSSGPLKADDSVPPGGSHI-------YNWTIPEGHAPTDADPACLTWIYHSHVDAPRD 197
Query: 549 IFTGLIGPMKICKKGSLHANG--RQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQ 606
I TGLIGP+ CK+G+L N +++DVD +F+L +V DEN S L +NI + + P
Sbjct: 198 IATGLIGPLITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPAS 257
Query: 607 VDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYL 666
VDKEDE FQESN+MH++NGF++GN P L MC V W+LF GNE DVH +F G
Sbjct: 258 VDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLT 317
Query: 667 WRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDST 726
RG D AN+FP T +T M P GT+ + C H+ GM+ Y V C
Sbjct: 318 TRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDL 377
Query: 727 FYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQ-NVSNAFLDKGEFYIGSKYKKVVYR 785
R Y+I A E++WDY P +L+E ++S+ F K IG Y KV Y
Sbjct: 378 LTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYE 437
Query: 786 QYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTE--- 842
+ D TF+ + + E+ HLGILGP + A+VGD ++++F N A++P+S+ HGV E
Sbjct: 438 AFQDETFQEKMHLE-EDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDY 496
Query: 843 ------SSTVTPTL---PGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGL 893
+ P L P E +TY W +P +G +D AC+ W Y+S D ++D SGL
Sbjct: 497 EGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGL 556
Query: 894 IGPLIVCRRPYLKVFNPRRKL--EFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEE 951
+GPL+VCR L ++ + EF LLF V DEN+SWY + N +++D E
Sbjct: 557 VGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEG 616
Query: 952 FIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVY 1011
F +SN+MHAING +F NL L M GD V W+L+G+G E D+H V F G++ Q +G+
Sbjct: 617 FQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQL--QGMR 674
Query: 1012 SSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQ 1058
+FP T+ M P G + ++C H AGM Y V Q
Sbjct: 675 KGAAM-LFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQ 720
>gi|7662254 hephaestin isoform b [Homo sapiens]
Length = 891
Score = 830 bits (2145), Expect = 0.0
Identities = 403/810 (49%), Positives = 537/810 (66%), Gaps = 17/810 (2%)
Query: 259 MYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFP 318
M+++NG+ FG+LP L+MCA+ RV W+LFGMGNE+DVH AFFHGQ LT + + D N+FP
Sbjct: 1 MHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFP 60
Query: 319 ATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGKHVRHYYIAA 378
AT A MV PG W++SCQ +H + G+QA ++V+ C+ + D + GK VR Y+I A
Sbjct: 61 ATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGK-VRQYFIEA 119
Query: 379 EEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNRKE 438
EI W+Y P G D T +NL PGS S FF++ ++RIGG+Y K+ Y + D +F K
Sbjct: 120 HEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETF-QEKM 178
Query: 439 RGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQ 498
E+ HLGILGPVI AEVGDTI+V F+N+ + P S++P GV + K+ EGT Y+
Sbjct: 179 HLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYN-----D 233
Query: 499 SRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFTGLIGPMK 558
S P + P E TY WTVP GPT DP CL MY+SA DP +D +GL+GP+
Sbjct: 234 GSSYPGLVAK--PFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLL 291
Query: 559 ICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQESN 618
+C+ G+L A+G+QK VDKEF+L TV DEN+S N + ++ E FQ+SN
Sbjct: 292 VCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSN 351
Query: 619 KMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTANLF 678
+MH++NGF++ N P L MCKGD+V W+L G E DVHG+ F GNT +G R+ A LF
Sbjct: 352 RMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLF 411
Query: 679 PQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCR-RQSEDSTFYLGERTYYIA 737
P T + M PD GTF + C H GM+ Y V+QC Q+ Y R YYI
Sbjct: 412 PHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIM 471
Query: 738 AVEVEWDYSPQREWEKELHHLQEQN-VSNAFLDKGEFYIGSKYKKVVYRQYTDSTFRVPV 796
A EVEWDY P R WE+E H+ E++ FL + +GS+YKK V+R+YTD TFR+P
Sbjct: 472 AEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPR 531
Query: 797 ERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTESSTVTPTL--PGET 854
R EEHLGILGP + +VGD + ++FKN A+RPYS+HAHGV ES+TV P PGE
Sbjct: 532 PRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGV-LESTTVWPLAAEPGEV 590
Query: 855 LTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFNPRRKL 914
+TY W IPERSG G DSAC+ W YYS VD +KD+YSGL+GPL +C++ L+ R +
Sbjct: 591 VTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDM 650
Query: 915 --EFALLFLVFDENESWYLDDNIKTY-SDHPEKVNKDDEEFIESNKMHAINGRMFGNLQG 971
EFALLFL+FDEN+SWYL++N+ T+ S P +N DE F+ESNKMHAING+++ NL+G
Sbjct: 651 DREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRG 710
Query: 972 LTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPR 1031
LTM+ G+ V WY++ MG ++DLHT+HFH SF Y++ Y +DV D+FPGT++ +EM
Sbjct: 711 LTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVAS 770
Query: 1032 TPGIWLLHCHVTDHIHAGMETTYTVLQNED 1061
PG WL+HCHVTDH+HAGMET +TV +
Sbjct: 771 NPGTWLMHCHVTDHVHAGMETLFTVFSRTE 800
Score = 476 bits (1225), Expect = e-134
Identities = 267/712 (37%), Positives = 386/712 (54%), Gaps = 43/712 (6%)
Query: 20 KEKHYYIGIIETTWDYAS---DHGEKKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYT 76
K + Y+I E WDY D K + S+ + Q RIG Y K Y +
Sbjct: 111 KVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQ 170
Query: 77 DETFRTT--IEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAI 134
DETF+ +E+ LG LGP+I+AE GD + V N AS+P++ HG+ Y K++EG +
Sbjct: 171 DETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTV 230
Query: 135 YPDNTTDFQRADDKVYPG------EQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKD 188
Y D ++ YPG E+ TY P D C+T +Y S D +D
Sbjct: 231 YNDGSS---------YPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRD 281
Query: 189 IASGLIGPLIICKKDSLDKE-KEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVD 247
SGL+GPL++C+ +L + K+K +D+EF ++F+V+DEN SWY N + +
Sbjct: 282 TNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLS 341
Query: 248 KDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNK 307
+D E FQ+SNRM+++NG+ F +LP L MC D V W+L G+G E DVH F G + +
Sbjct: 342 EDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQ 401
Query: 308 NYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIR 367
R LFP T A M N G + + CQ +H +AG++A + V +C + R
Sbjct: 402 GMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQR 461
Query: 368 GKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYRE 427
+ R YYI AEE+ W+Y P N + S +F +G YKK V+RE
Sbjct: 462 YQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFRE 521
Query: 428 YTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNE 487
YTD +F + R EEHLGILGP+I EVGD + V F N + P S+ GV
Sbjct: 522 YTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVL------ 575
Query: 488 GTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTK 547
+S +V P A+ P E TY+W +P+ GP D C++ +YYSAVDP K
Sbjct: 576 ----------ESTTVWPLAAE--PGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIK 623
Query: 548 DIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMF-TTAPDQ 606
D+++GL+GP+ IC+KG L +G + D+D+EF L +FDEN+S LE+N+ + P
Sbjct: 624 DMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGS 683
Query: 607 VDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYL 666
++ +DE F ESNKMH++NG +Y N GLTM +G+ V WY+ + G + D+H I+F ++L
Sbjct: 684 INLQDETFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFL 743
Query: 667 WR-GE--RRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTV 715
+R GE R D +LFP T + M GT+ + C TDH GM+ +TV
Sbjct: 744 YRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTV 795
>gi|4503647 coagulation factor VIII isoform a precursor [Homo
sapiens]
Length = 2351
Score = 426 bits (1096), Expect = e-119
Identities = 261/766 (34%), Positives = 391/766 (51%), Gaps = 81/766 (10%)
Query: 6 LGIFLFLCSTP-AWAKEKHYYIGIIETTWDYA-SDHGEKKLISVDTEHSNIYLQNGPDRI 63
L FLC ++ + YY+G +E +WDY SD GE + VD ++ P
Sbjct: 5 LSTCFFLCLLRFCFSATRRYYLGAVELSWDYMQSDLGE---LPVDARFPPRVPKSFPFNT 61
Query: 64 GRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHG 123
+YKK L++++TD F +P W+G LGP I+AE D V + LKN+AS P + H+ G
Sbjct: 62 SVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVG 121
Query: 124 ITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHI 183
++Y+K EGA Y D T+ ++ DDKV+PG +TY+ +E P D C+T Y SH+
Sbjct: 122 VSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHV 181
Query: 184 DAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEP 243
D KD+ SGLIG L++C++ SL KEK + + +F+++F+V DE SW+ E
Sbjct: 182 DLVKDLNSGLIGALLVCREGSLAKEKTQTL-HKFILLFAVFDEGKSWHSE------TKNS 234
Query: 244 EKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQA 303
D+D + +M++VNGY SLPGL C V W++ GMG +VH+ F G
Sbjct: 235 LMQDRDAASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHT 294
Query: 304 LTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQEC------ 357
+N+R ++ + P T A + + G+++L C +H G++A+ +V C
Sbjct: 295 FLVRNHRQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQL 354
Query: 358 ---NKSSSKD------------------------NIRGKHVRH-----YYIAAEEIIWNY 385
N ++D IR +H +YIAAEE W+Y
Sbjct: 355 RMKNNEEAEDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDY 414
Query: 386 APSGIDIFTKENLTAPGSDS--AVFFEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEE 443
AP + AP S + + G RIG YKK+ + YTD +F K R +
Sbjct: 415 APL---------VLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETF---KTREAIQ 462
Query: 444 EHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRSVP 503
GILGP+++ EVGDT+ + F N+ + P +I P G+ T P Y SR +P
Sbjct: 463 HESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGI--------TDVRPLY---SRRLP 511
Query: 504 PSASH-----VAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFTGLIGPMK 558
H + P E F Y+WTV E GPT +DP CL + Y S V+ +D+ +GLIGP+
Sbjct: 512 KGVKHLKDFPILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLL 571
Query: 559 ICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQESN 618
IC K S+ G Q DK + +VFDEN S L +NI+ F P V ED +FQ SN
Sbjct: 572 ICYKESVDQRGNQIMSDKRNVILFSVFDENRSWYLTENIQRFLPNPAGVQLEDPEFQASN 631
Query: 619 KMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTANLF 678
MHS+NG+++ + L++C + WY+ S G + D ++FSG T+ + DT LF
Sbjct: 632 IMHSINGYVFDSLQ-LSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKHKMVYEDTLTLF 690
Query: 679 PQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSED 724
P + T+ M + G + + C +D GM V+ C + + D
Sbjct: 691 PFSGETVFMSMENPGLWILGCHNSDFRNRGMTALLKVSSCDKNTGD 736
Score = 369 bits (948), Expect = e-102
Identities = 241/736 (32%), Positives = 367/736 (49%), Gaps = 93/736 (12%)
Query: 372 RHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDA 431
R YY+ A E+ W+Y S + + P + F YKK ++ E+TD
Sbjct: 22 RRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFNTSVV-----YKKTLFVEFTDH 76
Query: 432 SFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYY 491
F K R P +G+LGP I AEV DT+ +T N ++P+S+ +GV + K +EG
Sbjct: 77 LFNIAKPRPP---WMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGA-- 131
Query: 492 SPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIFT 551
Y+ Q+ V P + TY W V KE GP +DP+CL Y S VD KD+ +
Sbjct: 132 --EYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNS 189
Query: 552 GLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKED 611
GLIG + +C++GSL A + + + K LF VFDE +S E + D++
Sbjct: 190 GLIGALLVCREGSL-AKEKTQTLHKFILLF-AVFDEGKSWHSETKNSLMQ------DRDA 241
Query: 612 EDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGER 671
+ KMH++NG++ + PGL C SV W++ G +VH I+ G+T+L R R
Sbjct: 242 ASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHR 301
Query: 672 RDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQC-------RRQSED 724
+ + + P T LT G F + C + H GM+ V+ C + +E+
Sbjct: 302 QASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNEE 361
Query: 725 STFYLGERT--------------------------------YYIAAVEVEWDYSPQREWE 752
+ Y + T +YIAA E +WDY+P
Sbjct: 362 AEDYDDDLTDSEMDVVRFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPL---- 417
Query: 753 KELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQL 812
+ +++ + +L+ G IG KYKKV + YTD TF+ R+A + GILGP L
Sbjct: 418 --VLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKT---REAIQHESGILGPLL 472
Query: 813 HADVGDKVKIIFKNMATRPYSIHAHGVQTESSTVT-------------PTLPGETLTYVW 859
+ +VGD + IIFKN A+RPY+I+ HG+ + P LPGE Y W
Sbjct: 473 YGEVGDTLLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKW 532
Query: 860 KIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYL-----KVFNPRRKL 914
+ G D C+ Y S V+ +DL SGLIGPL++C + + ++ + +R +
Sbjct: 533 TVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNV 592
Query: 915 EFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTM 974
+LF VFDEN SWYL +NI+ + +P V +D EF SN MH+ING +F +LQ L++
Sbjct: 593 ---ILFSVFDENRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQ-LSV 648
Query: 975 HVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPG 1034
+ + WY++ +G + D +V F G++F KH+ VY D +FP + +T+ M PG
Sbjct: 649 CLHEVAYWYILSIGAQTDFLSVFFSGYTF--KHKMVY-EDTLTLFPFSGETVFMSMENPG 705
Query: 1035 IWLLHCHVTDHIHAGM 1050
+W+L CH +D + GM
Sbjct: 706 LWILGCHNSDFRNRGM 721
Score = 243 bits (619), Expect = 9e-64
Identities = 125/360 (34%), Positives = 193/360 (53%), Gaps = 22/360 (6%)
Query: 710 KQKYTVNQCRRQSEDSTFYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLD 769
K+ + + +F R Y+IAAVE WDY H L+ + S +
Sbjct: 1693 KEDFDIYDEDENQSPRSFQKKTRHYFIAAVERLWDYG----MSSSPHVLRNRAQSGSV-- 1746
Query: 770 KGEFYIGSKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMAT 829
++KKVV++++TD +F P+ R EHLG+LGP + A+V D + + F+N A+
Sbjct: 1747 -------PQFKKVVFQEFTDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQAS 1799
Query: 830 RPYSIHAHGVQTESST---VTP----TLPGETLTYVWKIPERSGAGTEDSACIPWAYYST 882
RPYS ++ + E P P ET TY WK+ ++ C WAY+S
Sbjct: 1800 RPYSFYSSLISYEEDQRQGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSD 1859
Query: 883 VDQVKDLYSGLIGPLIVCRRPYLKVFNPRRKL--EFALLFLVFDENESWYLDDNIKTYSD 940
VD KD++SGLIGPL+VC L + R+ EFAL F +FDE +SWY +N++
Sbjct: 1860 VDLEKDVHSGLIGPLLVCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERNCR 1919
Query: 941 HPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHG 1000
P + +D F E+ + HAING + L GL M + WYL+ MG+ ++H++HF G
Sbjct: 1920 APCNIQMEDPTFKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSG 1979
Query: 1001 HSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNE 1060
H F + + Y +++++PG ++T+EM P GIW + C + +H+HAGM T + V N+
Sbjct: 1980 HVFTVRKKEEYKMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNK 2039
Score = 211 bits (537), Expect = 3e-54
Identities = 126/357 (35%), Positives = 185/357 (51%), Gaps = 33/357 (9%)
Query: 369 KHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREY 428
K RHY+IAA E +W+Y S S V + + +KK+V++E+
Sbjct: 1712 KKTRHYFIAAVERLWDYGMS--------------SSPHVLRNRAQSGSVPQFKKVVFQEF 1757
Query: 429 TDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEG 488
TD SFT RG EHLG+LGP I AEV D I VTF N+ + P S + + ++
Sbjct: 1758 TDGSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEED--- 1814
Query: 489 TYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKD 548
Q + P + V P ET TY W V + PT + C A Y+S VD KD
Sbjct: 1815 ---------QRQGAEPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKD 1865
Query: 549 IFTGLIGPMKICKKGSLH-ANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQV 607
+ +GLIGP+ +C +L+ A+GRQ V +EF LF T+FDE +S +N+ AP +
Sbjct: 1866 VHSGLIGPLLVCHTNTLNPAHGRQVTV-QEFALFFTIFDETKSWYFTENMERNCRAPCNI 1924
Query: 608 DKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLW 667
ED F+E+ + H++NG++ PGL M + + WYL S G+ ++H I+FSG+ +
Sbjct: 1925 QMEDPTFKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTV 1984
Query: 668 RGE---RRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTV--NQCR 719
R + + NL+P T+ M P G + VECL +H GM + V N+C+
Sbjct: 1985 RKKEEYKMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNKCQ 2041
Score = 197 bits (501), Expect = 4e-50
Identities = 112/377 (29%), Positives = 183/377 (48%), Gaps = 31/377 (8%)
Query: 20 KEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRL--YKKALYLQYTD 77
K +HY+I +E WDY S+ ++ + G + +KK ++ ++TD
Sbjct: 1713 KTRHYFIAAVERLWDYGMS-------------SSPHVLRNRAQSGSVPQFKKVVFQEFTD 1759
Query: 78 ETFRTTI---EKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAI 134
+F + E LG LGP I+AE D + V +N ASRPY+F+S I+Y ++
Sbjct: 1760 GSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEEDQRQGA 1819
Query: 135 YPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLI 194
P V P E TY +P + + +C Y S +D KD+ SGLI
Sbjct: 1820 EPRKNF--------VKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLI 1871
Query: 195 GPLIICKKDSLDKEKEKHID-REFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDF 253
GPL++C ++L+ + + +EF + F++ DE SWY +N++ C P + ++ F
Sbjct: 1872 GPLLVCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERNCRAPCNIQMEDPTF 1931
Query: 254 QESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALT---NKNYR 310
+E+ R +++NGY +LPGL M + R++WYL MG+ ++H+ F G T + Y+
Sbjct: 1932 KENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYK 1991
Query: 311 IDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGKH 370
+ NL+P M+ G W + C HL AG+ F V NK + + H
Sbjct: 1992 MALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYS-NKCQTPLGMASGH 2050
Query: 371 VRHYYIAAEEIIWNYAP 387
+R + I A +AP
Sbjct: 2051 IRDFQITASGQYGQWAP 2067
Score = 171 bits (432), Expect = 4e-42
Identities = 110/335 (32%), Positives = 161/335 (48%), Gaps = 31/335 (9%)
Query: 732 RTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYRQYTDST 791
R YY+ AVE+ WDY E + V +F F YKK ++ ++TD
Sbjct: 22 RRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSF----PFNTSVVYKKTLFVEFTDHL 77
Query: 792 FRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTESSTV----- 846
F + K +G+LGP + A+V D V I KNMA+ P S+HA GV ++
Sbjct: 78 FNIA---KPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYD 134
Query: 847 ----------TPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGP 896
PG + TYVW++ + +G D C+ ++Y S VD VKDL SGLIG
Sbjct: 135 DQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGA 194
Query: 897 LIVCRRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESN 956
L+VCR L + +F LLF VFDE +SW+ + D +D
Sbjct: 195 LLVCREGSLAKEKTQTLHKFILLFAVFDEGKSWHSETKNSLMQD------RDAASARAWP 248
Query: 957 KMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVF 1016
KMH +NG + +L GL V W+++GMG ++H++ GH+F ++ S
Sbjct: 249 KMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQAS---L 305
Query: 1017 DIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGME 1051
+I P T+ T + G +LL CH++ H H GME
Sbjct: 306 EISPITFLTAQTLLMDLGQFLLFCHISSHQHDGME 340
>gi|105990535 coagulation factor V precursor [Homo sapiens]
Length = 2224
Score = 399 bits (1026), Expect = e-111
Identities = 232/675 (34%), Positives = 361/675 (53%), Gaps = 48/675 (7%)
Query: 67 YKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITY 126
+KK +Y +Y + F+ + G LGP + AE GD + VH KN A +P + H GI Y
Sbjct: 61 FKKIVYREY-EPYFKKEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRY 119
Query: 127 YKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAP 186
K EGA Y D+T ++ DD V PG +YTY +E+ P D C+T IY+SH +
Sbjct: 120 SKLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLI 179
Query: 187 KDIASGLIGPLIICKKDSLDKE-KEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEK 245
+D SGLIGPL+ICKK +L + +K D++ V++F+V DE+ SW
Sbjct: 180 EDFNSGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWS-------------- 225
Query: 246 VDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALT 305
Q S+ MY+VNGY G++P +++CA D + W+L GM + ++ + F+GQ L
Sbjct: 226 --------QSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLE 277
Query: 306 NKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQEC-NKSSSKD 364
++++ I L AT A M G+W++S HL+AG+QA+ ++ C K+ +
Sbjct: 278 QNHHKVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLK 337
Query: 365 NIRGKHVRH-----YYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGS 419
I + RH Y+IAAEE+IW+YAP K+ + + + +IG
Sbjct: 338 KITREQRRHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQ-------HLDNFSNQIGKH 390
Query: 420 YKKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIG 479
YKK++Y +Y D SFT P + GILGP+I A+V DT+++ F N + P SI P G
Sbjct: 391 YKKVMYTQYEDESFTKHTVN-PNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHG 449
Query: 480 VRFNKNNE---GTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLA 536
V F+ + ++ S N R+V P ET+TY+W + + PT D CL
Sbjct: 450 VTFSPYEDEVNSSFTSGRNNTMIRAVQPG-------ETYTYKWNILEFDEPTENDAQCLT 502
Query: 537 KMYYSAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDN 596
+ YYS VD +DI +GLIG + ICK SL G Q+ D E VFDEN+S LEDN
Sbjct: 503 RPYYSDVDIMRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDN 562
Query: 597 IRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVH 656
I F PD+V ++D F ESN M ++NG++ + L C D+V W+ S G + ++
Sbjct: 563 INKFCENPDEVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEIL 622
Query: 657 GIYFSGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVN 716
I+F+G+++++ DT LFP ++ + D GT+ + + + + ++ K+
Sbjct: 623 TIHFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDV 682
Query: 717 QCRRQSEDSTFYLGE 731
+C ++ ++ + E
Sbjct: 683 KCIPDDDEDSYEIFE 697
Score = 383 bits (984), Expect = e-106
Identities = 236/695 (33%), Positives = 351/695 (50%), Gaps = 89/695 (12%)
Query: 371 VRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTD 430
+R +Y+AA+ I W+Y P + ++T S+KK+VYREY
Sbjct: 31 LRQFYVAAQGISWSYRPEPTNSSLNLSVT-------------------SFKKIVYREYEP 71
Query: 431 ASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTY 490
K+ P+ G+LGP ++AEVGD I+V F NK PLSI P G+R++K +EG
Sbjct: 72 YF----KKEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGAS 127
Query: 491 YSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVDPTKDIF 550
Y + P + VAP +TYEW++ ++ GPT+ DP CL +YYS + +D
Sbjct: 128 YLDHTFPAEKM----DDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFN 183
Query: 551 TGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKE 610
+GLIGP+ ICKKG+L G QK DK+ L VFDE++S
Sbjct: 184 SGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWS------------------ 225
Query: 611 DEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGE 670
Q S+ M+++NG++ G P +T+C D + W+L + ++ I+F+G
Sbjct: 226 ----QSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHH 281
Query: 671 RRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDSTFYLG 730
+ L TS T +M EG + + LT H GM+ + C +++ +
Sbjct: 282 KVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITR 341
Query: 731 ERT-------YYIAAVEVEWDYSP--QREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKK 781
E+ Y+IAA EV WDY+P +K+ N SN IG YKK
Sbjct: 342 EQRRHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQHLDNFSNQ--------IGKHYKK 393
Query: 782 VVYRQYTDSTF-RVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQ 840
V+Y QY D +F + V +E+ GILGP + A V D +KI+FKNMA+RPYSI+ HGV
Sbjct: 394 VMYTQYEDESFTKHTVNPNMKED--GILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVT 451
Query: 841 ---------------TESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQ 885
++ + PGET TY W I E D+ C+ YYS VD
Sbjct: 452 FSPYEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDI 511
Query: 886 VKDLYSGLIGPLIVCRRPYLKVFNPRRK--LEFALLFLVFDENESWYLDDNIKTYSDHPE 943
++D+ SGLIG L++C+ L +R +E +F VFDEN+SWYL+DNI + ++P+
Sbjct: 512 MRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPD 571
Query: 944 KVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSF 1003
+V +DD +F ESN M ING + ++ L D V W+ +G + ++ T+HF GHSF
Sbjct: 572 EVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSF 631
Query: 1004 QYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLL 1038
Y G D +FP +++ + G W+L
Sbjct: 632 IY---GKRHEDTLTLFPMRGESVTVTMDNVGTWML 663
Score = 237 bits (605), Expect = 4e-62
Identities = 138/370 (37%), Positives = 199/370 (53%), Gaps = 45/370 (12%)
Query: 715 VNQCRRQSEDSTFYL-----GERTYYIAAVEVEWDYSP--QREWEKELHHLQEQNVSNAF 767
+N R + +YL R YYIAA E+ WDYS QRE + E
Sbjct: 1558 INSSRDPDNIAAWYLRSNNGNRRNYYIAAEEISWDYSEFVQRETDIE------------- 1604
Query: 768 LDKGEFYIGSKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNM 827
D + + YKKVV+R+Y DSTF R EEHLGILGP + A+V D +++ FKN+
Sbjct: 1605 -DSDDIPEDTTYKKVVFRKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNL 1663
Query: 828 ATRPYSIHAHGVQTESSTVTPTL---------------PGETLTYVWKIPERSGAGTEDS 872
A+RPYS+HAHG+ E S+ T P + TYVW ERSG + S
Sbjct: 1664 ASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGS 1723
Query: 873 ACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFN--PRRKLEFALLFLVFDENESWY 930
AC WAYYS V+ KD++SGLIGPL++C++ L + P EF LLF+ FDE +SWY
Sbjct: 1724 ACRAWAYYSAVNPEKDIHSGLIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWY 1783
Query: 931 LDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNE 990
+ ++ E +S++ HAING ++ +L GL M+ + V +L+ +G
Sbjct: 1784 YEKKSRS------SWRLTSSEMKKSHEFHAINGMIY-SLPGLKMYEQEWVRLHLLNIGGS 1836
Query: 991 IDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGM 1050
D+H VHFHG + + V+ + PG+++TLEM PG WLL+ V ++ AGM
Sbjct: 1837 QDIHVVHFHGQTLLENGNKQHQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGM 1896
Query: 1051 ETTYTVLQNE 1060
+T + ++ +
Sbjct: 1897 QTPFLIMDRD 1906
Score = 220 bits (561), Expect = 5e-57
Identities = 128/352 (36%), Positives = 184/352 (52%), Gaps = 13/352 (3%)
Query: 20 KEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDET 79
K Y+I E WDYA ++D ++ + +L N ++IG+ YKK +Y QY DE+
Sbjct: 348 KRWEYFIAAEEVIWDYAPVIPA----NMDKKYRSQHLDNFSNQIGKHYKKVMYTQYEDES 403
Query: 80 FRTTIEKPVWL--GFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGIT---YYKEHEGAI 134
F P G LGPII+A+ D + + KN+ASRPY+ + HG+T Y E +
Sbjct: 404 FTKHTVNPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDEVNSSF 463
Query: 135 YPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLI 194
RA V PGE YTY E P E D C+TR Y+S +D +DIASGLI
Sbjct: 464 TSGRNNTMIRA---VQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLI 520
Query: 195 GPLIICKKDSLDKEK-EKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDF 253
G L+ICK SLD+ ++ D E +F+V DEN SWYLEDNI +C P++V +D+ F
Sbjct: 521 GLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKF 580
Query: 254 QESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDT 313
ESN M ++NGY S+ L C +D V+W+ +G + ++ F G + DT
Sbjct: 581 YESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKRHEDT 640
Query: 314 INLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDN 365
+ LFP + N G WML+ N + L+ F+ +C +D+
Sbjct: 641 LTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDVKCIPDDDEDS 692
Score = 203 bits (517), Expect = 6e-52
Identities = 119/342 (34%), Positives = 182/342 (53%), Gaps = 24/342 (7%)
Query: 22 KHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDETFR 81
++YYI E +WDY+ E D E S+ ++ YKK ++ +Y D TF
Sbjct: 1580 RNYYIAAEEISWDYS----EFVQRETDIEDSDDIPED------TTYKKVVFRKYLDSTFT 1629
Query: 82 TTIEKPVW---LGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDN 138
+ + LG LGPII+AE D + V KNLASRPY+ H+HG++Y K EG Y D+
Sbjct: 1630 KRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDD 1689
Query: 139 TTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLI 198
+ ++ + D+ V P YTY+ ATE P C Y+S ++ KDI SGLIGPL+
Sbjct: 1690 SPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLL 1749
Query: 199 ICKKDSLDKEKEKHID-REFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESN 257
IC+K L K+ +D REFV++F DE SWY E ++ + + ++S+
Sbjct: 1750 ICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKSRS------SWRLTSSEMKKSH 1803
Query: 258 RMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALT---NKNYRIDTI 314
+++NG + SLPGL M ++ V+ +L +G D+H FHGQ L NK +++
Sbjct: 1804 EFHAINGMIY-SLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLGVW 1862
Query: 315 NLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQE 356
L P + M A PG W+L+ + + +AG+Q F + +
Sbjct: 1863 PLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMD 1904
Score = 193 bits (490), Expect = 8e-49
Identities = 128/377 (33%), Positives = 189/377 (50%), Gaps = 42/377 (11%)
Query: 358 NKSSSKDNIRGKHVR-------HYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFE 410
N S DNI ++R +YYIAAEEI W+Y+ F + SD
Sbjct: 1559 NSSRDPDNIAAWYLRSNNGNRRNYYIAAEEISWDYSE-----FVQRETDIEDSDD---IP 1610
Query: 411 QGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGA 470
+ TT YKK+V+R+Y D++FT R RG EEHLGILGP+I AEV D I+V F N +
Sbjct: 1611 EDTT-----YKKVVFRKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLAS 1665
Query: 471 YPLSIEPIGVRFNKNNEGTYY---SPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGP 527
P S+ G+ + K++EG Y SP + + +V P++S +TY W + GP
Sbjct: 1666 RPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSS-------YTYVWHATERSGP 1718
Query: 528 TNADPVCLAKMYYSAVDPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDE 587
+ C A YYSAV+P KDI +GLIGP+ IC+KG LH + +EF L FDE
Sbjct: 1719 ESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDE 1778
Query: 588 NESLLLEDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLF 647
+S E R + ++S++ H++NG +Y + PGL M + + V +L
Sbjct: 1779 KKSWYYEKKSR------SSWRLTSSEMKKSHEFHAINGMIY-SLPGLKMYEQEWVRLHLL 1831
Query: 648 SAGNEADVHGIYFSGNTYLWRGERRDTAN---LFPQTSLTLHMWPDTEGTFNVECLTTDH 704
+ G D+H ++F G T L G ++ L P + TL M G + + ++
Sbjct: 1832 NIGGSQDIHVVHFHGQTLLENGNKQHQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGEN 1891
Query: 705 YTGGMKQKYTV--NQCR 719
GM+ + + CR
Sbjct: 1892 QRAGMQTPFLIMDRDCR 1908
Score = 149 bits (376), Expect = 1e-35
Identities = 96/337 (28%), Positives = 159/337 (47%), Gaps = 64/337 (18%)
Query: 732 RTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYRQYTDST 791
R +Y+AA + W Y P+ +N+ L+ + +KK+VYR+Y +
Sbjct: 32 RQFYVAAQGISWSYRPEP--------------TNSSLNLSV----TSFKKIVYREY-EPY 72
Query: 792 FRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTE-----SSTV 846
F+ + K + G+LGP L+A+VGD +K+ FKN A +P SIH G++ +S +
Sbjct: 73 FK---KEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGASYL 129
Query: 847 TPTLPGETL----------TYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGP 896
T P E + TY W I E SG +D C+ YYS + ++D SGLIGP
Sbjct: 130 DHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGLIGP 189
Query: 897 LIVCRRPYLKVFNPRRKLE--FALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIE 954
L++C++ L ++ + LLF VFDE++SW ++
Sbjct: 190 LLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWSQSSSL------------------- 230
Query: 955 SNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSD 1014
M+ +NG + G + +T+ D ++W+L+GM + +L ++HF+G + H V
Sbjct: 231 ---MYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKV---S 284
Query: 1015 VFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGME 1051
+ T T M G W++ H+ AGM+
Sbjct: 285 AITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQ 321
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 35.0 bits (79), Expect = 0.38
Identities = 26/86 (30%), Positives = 38/86 (44%), Gaps = 5/86 (5%)
Query: 828 ATRPYSIHAHGVQTESSTVTPTLPG---ETLTYVWKIPERSGAGTEDSACIPWAYYSTVD 884
+T Y HA + +S+ P E V K P G G D + IP A +TVD
Sbjct: 119 STDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVD 178
Query: 885 QVKDLYSGLIGPLIVCRRPYLKVFNP 910
+ KD Y + + + +P L +NP
Sbjct: 179 RPKDWYKTMFKQIHMVHKPGL--YNP 202
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 33.5 bits (75), Expect = 1.1
Identities = 23/79 (29%), Positives = 34/79 (43%), Gaps = 3/79 (3%)
Query: 828 ATRPYSIHAHGVQTESSTVTPTLPG---ETLTYVWKIPERSGAGTEDSACIPWAYYSTVD 884
+T Y HA + +S+ P E V K P G G D + IP A +TVD
Sbjct: 212 STDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVD 271
Query: 885 QVKDLYSGLIGPLIVCRRP 903
+ KD Y + + + +P
Sbjct: 272 RPKDWYKTMFKQIHMVHKP 290
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 33.5 bits (75), Expect = 1.1
Identities = 23/79 (29%), Positives = 34/79 (43%), Gaps = 3/79 (3%)
Query: 828 ATRPYSIHAHGVQTESSTVTPTLPG---ETLTYVWKIPERSGAGTEDSACIPWAYYSTVD 884
+T Y HA + +S+ P E V K P G G D + IP A +TVD
Sbjct: 102 STDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVD 161
Query: 885 QVKDLYSGLIGPLIVCRRP 903
+ KD Y + + + +P
Sbjct: 162 RPKDWYKTMFKQIHMVHKP 180
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 33.5 bits (75), Expect = 1.1
Identities = 23/79 (29%), Positives = 34/79 (43%), Gaps = 3/79 (3%)
Query: 828 ATRPYSIHAHGVQTESSTVTPTLPG---ETLTYVWKIPERSGAGTEDSACIPWAYYSTVD 884
+T Y HA + +S+ P E V K P G G D + IP A +TVD
Sbjct: 119 STDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVD 178
Query: 885 QVKDLYSGLIGPLIVCRRP 903
+ KD Y + + + +P
Sbjct: 179 RPKDWYKTMFKQIHMVHKP 197
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 33.5 bits (75), Expect = 1.1
Identities = 23/79 (29%), Positives = 34/79 (43%), Gaps = 3/79 (3%)
Query: 828 ATRPYSIHAHGVQTESSTVTPTLPG---ETLTYVWKIPERSGAGTEDSACIPWAYYSTVD 884
+T Y HA + +S+ P E V K P G G D + IP A +TVD
Sbjct: 33 STDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVD 92
Query: 885 QVKDLYSGLIGPLIVCRRP 903
+ KD Y + + + +P
Sbjct: 93 RPKDWYKTMFKQIHMVHKP 111
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 33.5 bits (75), Expect = 1.1
Identities = 23/79 (29%), Positives = 34/79 (43%), Gaps = 3/79 (3%)
Query: 828 ATRPYSIHAHGVQTESSTVTPTLPG---ETLTYVWKIPERSGAGTEDSACIPWAYYSTVD 884
+T Y HA + +S+ P E V K P G G D + IP A +TVD
Sbjct: 79 STDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVD 138
Query: 885 QVKDLYSGLIGPLIVCRRP 903
+ KD Y + + + +P
Sbjct: 139 RPKDWYKTMFKQIHMVHKP 157
>gi|215490104 calpain 11 [Homo sapiens]
Length = 739
Score = 32.7 bits (73), Expect = 1.9
Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 2/62 (3%)
Query: 908 FNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKD--DEEFIESNKMHAINGRM 965
F P R +F L +ESW LD+ EKV++D D++F+ K+ A G+
Sbjct: 526 FEPHRDADFLLRVFTEKHSESWELDEVNYAEQLQEEKVSEDDMDQDFLHLFKIVAGEGKE 585
Query: 966 FG 967
G
Sbjct: 586 IG 587
>gi|122937436 tetratricopeptide repeat domain 39A isoform 2 [Homo
sapiens]
Length = 578
Score = 32.0 bits (71), Expect = 3.2
Identities = 27/126 (21%), Positives = 57/126 (45%), Gaps = 20/126 (15%)
Query: 748 QREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYRQ--YTDSTFRVPVERKAEEEHL 805
Q+ W K+ HH+ + F KG++ + Y ++ ++ ++ +T+ + KA +L
Sbjct: 310 QQHW-KQFHHMCYWELMWCFTYKGQWKMSYFYADLLSKENCWSKATY---IYMKAA--YL 363
Query: 806 GILGPQLHADVGD------------KVKIIFKNMATRPYSIHAHGVQTESSTVTPTLPGE 853
+ G + H GD K+KI K++ T ++I S+ ++ +P
Sbjct: 364 SMFGKEDHKPFGDDEVELFRAVPGLKLKIAGKSLPTEKFAIRKSRRYFSSNPISLPVPAL 423
Query: 854 TLTYVW 859
+ Y+W
Sbjct: 424 EMMYIW 429
>gi|221307588 tetratricopeptide repeat domain 39A isoform 1 [Homo
sapiens]
Length = 581
Score = 32.0 bits (71), Expect = 3.2
Identities = 27/126 (21%), Positives = 57/126 (45%), Gaps = 20/126 (15%)
Query: 748 QREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYRQ--YTDSTFRVPVERKAEEEHL 805
Q+ W K+ HH+ + F KG++ + Y ++ ++ ++ +T+ + KA +L
Sbjct: 313 QQHW-KQFHHMCYWELMWCFTYKGQWKMSYFYADLLSKENCWSKATY---IYMKAA--YL 366
Query: 806 GILGPQLHADVGD------------KVKIIFKNMATRPYSIHAHGVQTESSTVTPTLPGE 853
+ G + H GD K+KI K++ T ++I S+ ++ +P
Sbjct: 367 SMFGKEDHKPFGDDEVELFRAVPGLKLKIAGKSLPTEKFAIRKSRRYFSSNPISLPVPAL 426
Query: 854 TLTYVW 859
+ Y+W
Sbjct: 427 EMMYIW 432
>gi|237820624 pleckstrin homology domain containing, family N member
1 isoform b [Homo sapiens]
Length = 576
Score = 30.8 bits (68), Expect = 7.1
Identities = 25/87 (28%), Positives = 38/87 (43%), Gaps = 6/87 (6%)
Query: 489 TYYSPNYNPQSRSVPPSASHVAPTETFTYEW---TVPKEVGPTNADPVCLAKMYYSAVDP 545
T +SP Y PP+ SH T+ E + GPT + P+ + A DP
Sbjct: 415 TSHSPLY--ADPYTPPATSHRRVTDVRGLEEFLSAMQSARGPTPSSPLPSVPVSVPASDP 472
Query: 546 TKDIFTGLIGPMKICKKGSLHANGRQK 572
+ +G GP + KKG+L + Q+
Sbjct: 473 -RSCSSGPAGPYLLSKKGALQSRAAQR 498
>gi|237820622 pleckstrin homology domain containing, family N member
1 isoform a [Homo sapiens]
Length = 611
Score = 30.8 bits (68), Expect = 7.1
Identities = 25/87 (28%), Positives = 38/87 (43%), Gaps = 6/87 (6%)
Query: 489 TYYSPNYNPQSRSVPPSASHVAPTETFTYEW---TVPKEVGPTNADPVCLAKMYYSAVDP 545
T +SP Y PP+ SH T+ E + GPT + P+ + A DP
Sbjct: 450 TSHSPLY--ADPYTPPATSHRRVTDVRGLEEFLSAMQSARGPTPSSPLPSVPVSVPASDP 507
Query: 546 TKDIFTGLIGPMKICKKGSLHANGRQK 572
+ +G GP + KKG+L + Q+
Sbjct: 508 -RSCSSGPAGPYLLSKKGALQSRAAQR 533
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,870,137
Number of Sequences: 37866
Number of extensions: 2167014
Number of successful extensions: 4567
Number of sequences better than 10.0: 18
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 4272
Number of HSP's gapped (non-prelim): 43
length of query: 1065
length of database: 18,247,518
effective HSP length: 113
effective length of query: 952
effective length of database: 13,968,660
effective search space: 13298164320
effective search space used: 13298164320
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.