Search of human proteins with 4557339

Search of human proteins with 4557339

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557339 hydrogen/potassium-exchanging ATPase 4B [Homo
sapiens]
         (291 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557339 hydrogen/potassium-exchanging ATPase 4B [Homo sapiens]     615   e-176
gi|49574491 Na+/K+ -ATPase beta 2 subunit [Homo sapiens]              226   2e-59
gi|215490093 ATPase, (Na+)/K+ transporting, beta 4 polypeptide i...   197   7e-51
gi|6912256 ATPase, (Na+)/K+ transporting, beta 4 polypeptide iso...   189   2e-48
gi|4502281 Na+/K+ -ATPase beta 3 subunit [Homo sapiens]               178   4e-45
gi|49574489 Na+/K+ -ATPase beta 1 subunit isoform b [Homo sapiens]    150   2e-36
gi|4502277 Na+/K+ -ATPase beta 1 subunit isoform a [Homo sapiens]     150   2e-36
gi|222080109 orexin receptor 2 [Homo sapiens]                          30   3.3  
gi|239746650 PREDICTED: hypothetical protein [Homo sapiens]            30   3.3  
gi|222080095 orexin receptor 1 [Homo sapiens]                          29   5.6  

>gi|4557339 hydrogen/potassium-exchanging ATPase 4B [Homo sapiens]
          Length = 291

 Score =  615 bits (1586), Expect = e-176
 Identities = 291/291 (100%), Positives = 291/291 (100%)

Query: 1   MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLY 60
           MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLY
Sbjct: 1   MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLY 60

Query: 61  VLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGY 120
           VLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGY
Sbjct: 61  VLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGY 120

Query: 121 SPAAQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFI 180
           SPAAQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFI
Sbjct: 121 SPAAQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFI 180

Query: 181 IKMNRIVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPH 240
           IKMNRIVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPH
Sbjct: 181 IKMNRIVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPH 240

Query: 241 YSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIEK 291
           YSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIEK
Sbjct: 241 YSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIEK 291


>gi|49574491 Na+/K+ -ATPase beta 2 subunit [Homo sapiens]
          Length = 290

 Score =  226 bits (576), Expect = 2e-59
 Identities = 114/296 (38%), Positives = 176/296 (59%), Gaps = 12/296 (4%)

Query: 1   MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLY 60
           M   +EKK+CGQ +EE++ + WNP T Q +GRT + W +I L+Y+ FY  +T +F L ++
Sbjct: 1   MVIQKEKKSCGQVVEEWKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLTMW 60

Query: 61  VLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGY 120
           V++QTV  +TP YQD+L +PG+ +RP     + L+++ NVSD  +W    Q L+ FL  Y
Sbjct: 61  VMLQTVSDHTPKYQDRLATPGLMIRPKT---ENLDVIVNVSDTESWDQHVQKLNKFLEPY 117

Query: 121 SPA--AQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLAD-PNFGFEEGKP 177
           + +  AQ++ + C   +Y+ Q      N+ K +C+F    L NCSG+ D  ++G+  G+P
Sbjct: 118 NDSIQAQKNDV-CRPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHYGYSTGQP 176

Query: 178 CFIIKMNRIVKFLPSNGSAPRVDCAFL--DQPRELGQPLQVKYYPPNGTFSLHYFPYYGK 235
           C  IKMNR++ F      +  V CA    +    LG  +    +P NG   L YFPYYGK
Sbjct: 177 CVFIKMNRVINFYAGANQSMNVTCAGKRDEDAENLGNFVM---FPANGNIDLMYFPYYGK 233

Query: 236 KAQPHYSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIEK 291
           K   +Y+ PLVA K LN+  N EV + C++ A ++  ++  D + G+V FKL+I K
Sbjct: 234 KFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAGRVAFKLRINK 289


>gi|215490093 ATPase, (Na+)/K+ transporting, beta 4 polypeptide
           isoform A [Homo sapiens]
          Length = 357

 Score =  197 bits (502), Expect = 7e-51
 Identities = 99/280 (35%), Positives = 154/280 (55%), Gaps = 8/280 (2%)

Query: 12  QRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLYVLMQTVDPYTP 71
           Q+++    Y W+P+    L RT   W  I L Y  FY  +  +  LC+Y L  T+ PY P
Sbjct: 84  QKLQIMSEYLWDPERRMFLARTGQSWSLILLIYFFFYASLAAVITLCMYTLFLTISPYIP 143

Query: 72  DYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGYSPAAQED-SIN 130
            + ++++ PGV +RP  +    L   +NVS+  TW     +L+ FL GY+ + QE+ +++
Sbjct: 144 TFTERVKPPGVMIRPFAH---SLNFNFNVSEPDTWQHYVISLNGFLQGYNDSLQEEMNVD 200

Query: 131 CTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFIIKMNRIVKFL 190
           C   QYF Q+     +  K +C+F    L+NCSGL DP FG+  G+PC ++KMNRIV F 
Sbjct: 201 CPPGQYFIQDG--NEDEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFR 258

Query: 191 PSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPHYSNPLVAAKL 250
           P  G   +V C    Q  +      + YYP + +F L Y+PYYGK    +Y++PLVA   
Sbjct: 259 PELGDPVKVSCKV--QRGDENDIRSISYYPESASFDLRYYPYYGKLTHVNYTSPLVAMHF 316

Query: 251 LNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIE 290
            ++ +N  V + C++  + V  +  +D + G+V F L IE
Sbjct: 317 TDVVKNQAVPVQCQLKGKGVINDVINDRFVGRVIFTLNIE 356


>gi|6912256 ATPase, (Na+)/K+ transporting, beta 4 polypeptide
           isoform B [Homo sapiens]
          Length = 353

 Score =  189 bits (480), Expect = 2e-48
 Identities = 98/280 (35%), Positives = 153/280 (54%), Gaps = 12/280 (4%)

Query: 12  QRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLYVLMQTVDPYTP 71
           Q+++    Y W+P+    L RT      I L Y  FY  +  +  LC+Y L  T+ PY P
Sbjct: 84  QKLQIMSEYLWDPERRMFLART----GLILLIYFFFYASLAAVITLCMYTLFLTISPYIP 139

Query: 72  DYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGYSPAAQED-SIN 130
            + ++++ PGV +RP  +    L   +NVS+  TW     +L+ FL GY+ + QE+ +++
Sbjct: 140 TFTERVKPPGVMIRPFAHS---LNFNFNVSEPDTWQHYVISLNGFLQGYNDSLQEEMNVD 196

Query: 131 CTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFIIKMNRIVKFL 190
           C   QYF Q+     +  K +C+F    L+NCSGL DP FG+  G+PC ++KMNRIV F 
Sbjct: 197 CPPGQYFIQDGNE--DEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFR 254

Query: 191 PSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPHYSNPLVAAKL 250
           P  G   +V C    Q  +      + YYP + +F L Y+PYYGK    +Y++PLVA   
Sbjct: 255 PELGDPVKVSCKV--QRGDENDIRSISYYPESASFDLRYYPYYGKLTHVNYTSPLVAMHF 312

Query: 251 LNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIE 290
            ++ +N  V + C++  + V  +  +D + G+V F L IE
Sbjct: 313 TDVVKNQAVPVQCQLKGKGVINDVINDRFVGRVIFTLNIE 352


>gi|4502281 Na+/K+ -ATPase beta 3 subunit [Homo sapiens]
          Length = 279

 Score =  178 bits (452), Expect = 4e-45
 Identities = 100/285 (35%), Positives = 155/285 (54%), Gaps = 17/285 (5%)

Query: 6   EKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLYVLMQT 65
           EKK+  Q + E++ + +NP TG+ LGRT   W  I L+Y+ FY  +  LF+  ++V++QT
Sbjct: 5   EKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWVMLQT 64

Query: 66  VDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGYSPAAQ 125
           ++   P Y+DQ+ SPG+ + P       LE  ++ SD  ++A   + L  FL  Y+   Q
Sbjct: 65  LNDEVPKYRDQIPSPGLMVFPKPV--TALEYTFSRSDPTSYAGYIEDLKKFLKPYTLEEQ 122

Query: 126 EDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFIIKMNR 185
           ++   C     F Q   + P +   +C+F   +LQ CSG+ DP+FG+ +G PC ++KMNR
Sbjct: 123 KNLTVCPDGALFEQ---KGPVYV--ACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNR 177

Query: 186 IVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPHYSNPL 245
           I+   P     PR+DC   ++         V  YP NG   L YFPYYGKK    Y  PL
Sbjct: 178 IIGLKPE--GVPRIDCVSKNEDIP-----NVAVYPHNGMIDLKYFPYYGKKLHVGYLQPL 230

Query: 246 VAAKLLNIPRNA--EVAIVCKV-MAEHVTFNNPHDPYEGKVEFKL 287
           VA ++   P N   EV + CK+  + ++   +  D + G+V FK+
Sbjct: 231 VAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKI 275


>gi|49574489 Na+/K+ -ATPase beta 1 subunit isoform b [Homo sapiens]
          Length = 301

 Score =  150 bits (378), Expect = 2e-36
 Identities = 91/302 (30%), Positives = 152/302 (50%), Gaps = 29/302 (9%)

Query: 11  GQRMEE--FQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLYVLMQTVDP 68
           G+  EE  ++++ WN +  + LGRT   W  I L+YV FY  + G+F   + V++ T+  
Sbjct: 4   GKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISE 63

Query: 69  YTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGYSPAAQEDS 128
           + P YQD++  PG+T  P +   +  EI +  +D +++      +  FL  Y  +AQ D 
Sbjct: 64  FKPTYQDRVAPPGLTQIPQI---QKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDD 120

Query: 129 I---NCTSEQYFFQE--SFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFIIKM 183
           +   +C       +E   F      +  C+F  + L NCSGL D  +G++EGKPC IIK+
Sbjct: 121 MIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL 180

Query: 184 NRIVKFLPS---------------NGSAPRVDCAFLDQPRELGQPLQVKYYPPNGT--FS 226
           NR++ F P                N +   V C    +  +  +   V+Y+    +  F 
Sbjct: 181 NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTG-KRDEDKDKVGNVEYFGLGNSPGFP 239

Query: 227 LHYFPYYGKKAQPHYSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFK 286
           L Y+PYYGK  QP Y  PL+A +  N+  + E+ I CK   E++ ++   D ++G+ + K
Sbjct: 240 LQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSE-KDRFQGRFDVK 298

Query: 287 LK 288
           +K
Sbjct: 299 IK 300


>gi|4502277 Na+/K+ -ATPase beta 1 subunit isoform a [Homo sapiens]
          Length = 303

 Score =  150 bits (378), Expect = 2e-36
 Identities = 90/304 (29%), Positives = 154/304 (50%), Gaps = 29/304 (9%)

Query: 11  GQRMEE--FQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLYVLMQTVDP 68
           G+  EE  ++++ WN +  + LGRT   W  I L+YV FY  + G+F   + V++ T+  
Sbjct: 4   GKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISE 63

Query: 69  YTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGYSPAAQEDS 128
           + P YQD++  PG+T  P +   +  EI +  +D +++      +  FL  Y  +AQ D 
Sbjct: 64  FKPTYQDRVAPPGLTQIPQI---QKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDD 120

Query: 129 I---NCTSEQYFFQE--SFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFIIKM 183
           +   +C       +E   F      +  C+F  + L NCSGL D  +G++EGKPC IIK+
Sbjct: 121 MIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL 180

Query: 184 NRIVKFLPS---------------NGSAPRVDCAFLDQPRELGQPLQVKYYPPNGT--FS 226
           NR++ F P                N +   V C    +  +  +   V+Y+    +  F 
Sbjct: 181 NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTG-KRDEDKDKVGNVEYFGLGNSPGFP 239

Query: 227 LHYFPYYGKKAQPHYSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFK 286
           L Y+PYYGK  QP Y  PL+A +  N+  + E+ I CK   E++ ++   D ++G+ + K
Sbjct: 240 LQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSE-KDRFQGRFDVK 298

Query: 287 LKIE 290
           ++++
Sbjct: 299 IEVK 302


>gi|222080109 orexin receptor 2 [Homo sapiens]
          Length = 444

 Score = 29.6 bits (65), Expect = 3.3
 Identities = 20/59 (33%), Positives = 27/59 (45%), Gaps = 8/59 (13%)

Query: 15 EEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLYVL----MQTVDPY 69
          EEF RY W     + L      WV I+ Y + F V + G   +C+ V     M+TV  Y
Sbjct: 37 EEFLRYLWR----EYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNY 91


>gi|239746650 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 486

 Score = 29.6 bits (65), Expect = 3.3
 Identities = 14/49 (28%), Positives = 25/49 (51%)

Query: 81  GVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGYSPAAQEDSI 129
           G+     VY     + +Y+++++     LT+TLHA +      A EDS+
Sbjct: 228 GIANEDSVYDIANEDAIYDIANDTVQGTLTRTLHANVDTVHDIANEDSV 276


>gi|222080095 orexin receptor 1 [Homo sapiens]
          Length = 425

 Score = 28.9 bits (63), Expect = 5.6
 Identities = 20/59 (33%), Positives = 25/59 (42%), Gaps = 8/59 (13%)

Query: 15 EEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLYVL----MQTVDPY 69
          +EF RY W       L      WV I+ Y   F V + G   +CL V     M+TV  Y
Sbjct: 29 DEFLRYLWR----DYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNY 83


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,194,395
Number of Sequences: 37866
Number of extensions: 554345
Number of successful extensions: 959
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 933
Number of HSP's gapped (non-prelim): 10
length of query: 291
length of database: 18,247,518
effective HSP length: 101
effective length of query: 190
effective length of database: 14,423,052
effective search space: 2740379880
effective search space used: 2740379880
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.