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Search of human proteins with 4557251
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557251 ADAM metallopeptidase domain 10 [Homo sapiens]
(748 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557251 ADAM metallopeptidase domain 10 [Homo sapiens] 1584 0.0
gi|73747889 a disintegrin and metalloprotease domain 17 prepropr... 254 2e-67
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H... 122 9e-28
gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprot... 117 4e-26
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot... 117 4e-26
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens] 117 5e-26
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro... 110 4e-24
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop... 110 4e-24
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor... 108 2e-23
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor... 108 2e-23
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor... 108 2e-23
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor... 108 2e-23
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor... 108 2e-23
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor... 108 2e-23
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot... 100 6e-21
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot... 100 6e-21
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot... 100 6e-21
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot... 100 6e-21
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote... 100 6e-21
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ... 100 8e-21
gi|7656861 a disintegrin and metalloprotease domain 18 prepropro... 98 2e-20
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot... 96 9e-20
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot... 96 9e-20
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s... 93 8e-19
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ... 91 5e-18
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi... 86 1e-16
gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo s... 85 3e-16
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ... 81 3e-15
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ... 77 8e-14
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo... 74 5e-13
>gi|4557251 ADAM metallopeptidase domain 10 [Homo sapiens]
Length = 748
Score = 1584 bits (4102), Expect = 0.0
Identities = 748/748 (100%), Positives = 748/748 (100%)
Query: 1 MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL 60
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
Sbjct: 1 MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL 60
Query: 61 RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI 120
RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
Sbjct: 61 RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI 120
Query: 121 DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE 180
DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
Sbjct: 121 DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE 180
Query: 181 RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE 240
RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
Sbjct: 181 RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE 240
Query: 241 AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF 300
AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
Sbjct: 241 AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF 300
Query: 301 LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT 360
LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
Sbjct: 301 LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT 360
Query: 361 GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR 420
GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
Sbjct: 361 GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR 420
Query: 421 ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK 480
ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
Sbjct: 421 ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK 480
Query: 481 DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT 540
DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
Sbjct: 481 DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT 540
Query: 541 ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK 600
ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
Sbjct: 541 ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK 600
Query: 601 KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA 660
KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
Sbjct: 601 KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA 660
Query: 661 IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL 720
IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
Sbjct: 661 IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL 720
Query: 721 KRRRPPQPIQQPQRQRPRESYQMGHMRR 748
KRRRPPQPIQQPQRQRPRESYQMGHMRR
Sbjct: 721 KRRRPPQPIQQPQRQRPRESYQMGHMRR 748
>gi|73747889 a disintegrin and metalloprotease domain 17
preproprotein [Homo sapiens]
Length = 824
Score = 254 bits (650), Expect = 2e-67
Identities = 190/648 (29%), Positives = 290/648 (44%), Gaps = 68/648 (10%)
Query: 25 LNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSD 84
L+ + Y+ LS + H +R + +H + L F A RHF L + T FS
Sbjct: 35 LDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLT--FSALKRHFKLYLTSSTERFSQ 92
Query: 85 EFKVETSNKVLDYDTS----HIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPA 140
FKV + + + + +TGH+ GE S + D I T G + +EP
Sbjct: 93 NFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPL 152
Query: 141 ERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEE 200
R++ D T ++Y +DI + C + ++ ++ V + P EE
Sbjct: 153 WRFVND-TKDKRMLVYKSEDIKNVSRLQSPKVCG----YLKVDNEELLPKGLVDREPPEE 207
Query: 201 HAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE--AVIAQISSHVKAIDTIYQ 258
++++ KNTC+L + DH F++Y G E + + +D IY+
Sbjct: 208 LVHR----VKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYR 263
Query: 259 TT--DFSGIRNISFMVKRIRINTTADEKDPTNPF-----RFPNI-----GVEKFLELNS- 305
T D +G + +++IRI + E P +PN V+ LE S
Sbjct: 264 NTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSF 323
Query: 306 --EQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSS-GGICEKSKLYSDGKKKS-LNTG 361
+ CLA++FT +DFD G LGLA+VG+P +S GG+C K+ GKK LN+G
Sbjct: 324 DIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSG 383
Query: 362 IITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSG--TECTPGESKNLGQKENGNYIMYA 419
+ + +NYG + K + + HE+GHNFG+ HD EC P E + G Y+MY
Sbjct: 384 LTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNED------QGGKYVMYP 437
Query: 420 RATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQC 479
A SGD NN FS CS ++I + +E K CF E +CGN V++GEECD G
Sbjct: 438 IAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLN 497
Query: 480 KDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRD--DSDCAREGICN 537
D CC C LK G QCS PCC C F++ +KC++ ++ C C
Sbjct: 498 NDTCC-------NSDCTLKEGVQCSDRNSPCC-KNCQFETAQKKCQEAINATCKGVSYCT 549
Query: 538 GFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVC 597
G ++ CP + T C C +G+C + LE C C +D C VC
Sbjct: 550 GNSSECPPPGNAEDDTVC-LDLGKCKDGKCIPFCEREQQLESCACNETDNS-----CKVC 603
Query: 598 CMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRC 645
C + + + Q + + L+ G PC G+CD+ +C
Sbjct: 604 C-RDLSGRCVPYVDAEQ-------KNLFLRKGKPCT--VGFCDMNGKC 641
>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
sapiens]
Length = 819
Score = 122 bits (307), Expect = 9e-28
Identities = 139/546 (25%), Positives = 216/546 (39%), Gaps = 99/546 (18%)
Query: 42 LHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSH 101
L ++ + A R S + ++ A G+ + ++R+ L ++F V T NK T H
Sbjct: 51 LTRERREAPRPYSKQVSYV---IQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDH 107
Query: 102 I-------YTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSV 154
Y G++ G S S G G + ++ +EP + + F +
Sbjct: 108 PNIQNHCHYRGYVEGVHNSSIALSDCFG-LRGLLHLENASYGIEPLQN-----SSHFEHI 161
Query: 155 IYHEDDI-NYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKR 213
IY DD+ P K G +E+ T +EE + +LLR++R
Sbjct: 162 IYRMDDVYKEPLKCGVSN----------------KDIEKETAKDEEEEPPSMTQLLRRRR 205
Query: 214 TTSAEKNTCQLYIQTDHLFFKYYGTRE-AVIAQISSHVKAIDTIYQTTDFSGIR-NISFM 271
+ +L+I D + G + AV ++ +D++Y + + +
Sbjct: 206 AVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIW 265
Query: 272 VKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLA 331
IN D F EKFL + + HD A + + F G G+A
Sbjct: 266 TNGNLINIVGGAGDVLGNFVQWR---EKFLI--TRRRHDS---AQLVLKKGFG-GTAGMA 316
Query: 332 WVGAPSGSSGGICEKSKLYSDGKKKSLNT-GIITVQNYGSHVPPKVSHITFAHEVGHNFG 390
+VG +C +S ++ G +N G ITV+ + S V AHE+GHN G
Sbjct: 317 FVGT-------VCSRS--HAGG----INVFGQITVETFASIV---------AHELGHNLG 354
Query: 391 SPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNN 450
HD G +C+ G + IM + A+ + FS CS + ++ K N
Sbjct: 355 MNHDDGRDCSCGAK---------SCIMNSGASG-----SRNFSSCSAEDFEKLTLNKGGN 400
Query: 451 CFVESGQP-------ICGNGMVEQGEECDCGYSDQCK-DECCFDANQPEGRKCKLKPGKQ 502
C + +P CGN +V+ GEECDCG +C+ D CC EG CKLK +
Sbjct: 401 CLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDPCC------EGSTCKLKSFAE 454
Query: 503 CSPSQGPCCTAQCAFKSKSEKCR-DDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQV 561
C + G CC C F CR S+C CNG + C N C +
Sbjct: 455 C--AYGDCC-KDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAY 511
Query: 562 CINGQC 567
C NG C
Sbjct: 512 CYNGMC 517
Score = 33.1 bits (74), Expect = 0.97
Identities = 42/186 (22%), Positives = 63/186 (33%), Gaps = 28/186 (15%)
Query: 500 GKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREG---ICNGFTALCPASDPKPNFT--- 553
G+ CS C C S + R+ S C+ E + C + PKP+
Sbjct: 360 GRDCS-----CGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSA 414
Query: 554 --------------DCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCM 599
DC + ++ C GS C+ EC A D D +
Sbjct: 415 PSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAEC--AYGDCCKDCRFLPGGTL 472
Query: 600 KKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKK 659
+ S C S F + +Q G PC + + YC M C+ DA + K
Sbjct: 473 CRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGM-CQYYDAQCQVIFGSK 531
Query: 660 AIFSPE 665
A +P+
Sbjct: 532 AKAAPK 537
>gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprotein
[Homo sapiens]
Length = 540
Score = 117 bits (293), Expect = 4e-26
Identities = 127/550 (23%), Positives = 218/550 (39%), Gaps = 100/550 (18%)
Query: 42 LHQKHQRAKRAVSHEDQF---LRLDFHAHGRHFNLRMKRDTSLFSDEF----------KV 88
LH H+R + ++QF L+ +G+ L +K++ +L + + ++
Sbjct: 36 LHPLHKREAKEPEQQEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEI 95
Query: 89 ETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRT 148
TS +++D Y GHI E+ S + S G G+ +++EP +D
Sbjct: 96 TTSPQIMD---DCYYQGHILNEKVSDASISTCRG-LRGYFSQGDQRYFIEPLSPIHRDGQ 151
Query: 149 LPFHSVI-YHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPE 207
H++ Y+ D+ NY G G H + Q+ A +
Sbjct: 152 E--HALFKYNPDEKNYDSTCGMDGVLWAHDL-------------------QQNIALPATK 190
Query: 208 LLR-KKRTTSAEKNTCQLYIQTDHLFFKYYG-TREAVIAQISSHVKAIDTIYQTTDFSGI 265
L++ K R + + Y+ D+ FK Y ++ + ++ ++ +Y+ +
Sbjct: 191 LVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLN---- 246
Query: 266 RNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDD 325
+++ + I + + P F N + L+ + HD +A + T +
Sbjct: 247 THVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHD---IAQLITATELAG 303
Query: 326 GVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEV 385
+GLA++ +C YS G + + ++ V T AHE+
Sbjct: 304 TTVGLAFMST-------MCSP---YSVGVVQDHSDNLLRVAG------------TMAHEM 341
Query: 386 GHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLE 445
GHNFG HD + C + + K YI FS CS + + E
Sbjct: 342 GHNFGMFHDDYS-CKCPSTICVMDKALSFYIP------------TDFSSCSRLSYDKFFE 388
Query: 446 KKRNNCFVES-------GQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLK 498
K +NC + PICGN +VE GE+CDCG S++C + CC + + CK+K
Sbjct: 389 DKLSNCLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICC------DAKTCKIK 442
Query: 499 PGKQCSPSQGPCCTAQCAFKSKSEKCRDDSD-CAREGICNGFTALCPASDPKPNFTDCNR 557
QC + G CC +C FK CR D C +CNG + CP + N C+
Sbjct: 443 ATFQC--ALGECC-EKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHH 499
Query: 558 HTQVCINGQC 567
C+ G C
Sbjct: 500 GKGHCLMGTC 509
>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
[Homo sapiens]
Length = 775
Score = 117 bits (293), Expect = 4e-26
Identities = 127/550 (23%), Positives = 218/550 (39%), Gaps = 100/550 (18%)
Query: 42 LHQKHQRAKRAVSHEDQF---LRLDFHAHGRHFNLRMKRDTSLFSDEF----------KV 88
LH H+R + ++QF L+ +G+ L +K++ +L + + ++
Sbjct: 36 LHPLHKREAKEPEQQEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEI 95
Query: 89 ETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRT 148
TS +++D Y GHI E+ S + S G G+ +++EP +D
Sbjct: 96 TTSPQIMD---DCYYQGHILNEKVSDASISTCRG-LRGYFSQGDQRYFIEPLSPIHRDGQ 151
Query: 149 LPFHSVI-YHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPE 207
H++ Y+ D+ NY G G H + Q+ A +
Sbjct: 152 E--HALFKYNPDEKNYDSTCGMDGVLWAHDL-------------------QQNIALPATK 190
Query: 208 LLR-KKRTTSAEKNTCQLYIQTDHLFFKYYG-TREAVIAQISSHVKAIDTIYQTTDFSGI 265
L++ K R + + Y+ D+ FK Y ++ + ++ ++ +Y+ +
Sbjct: 191 LVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLN---- 246
Query: 266 RNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDD 325
+++ + I + + P F N + L+ + HD +A + T +
Sbjct: 247 THVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHD---IAQLITATELAG 303
Query: 326 GVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEV 385
+GLA++ +C YS G + + ++ V T AHE+
Sbjct: 304 TTVGLAFMST-------MCSP---YSVGVVQDHSDNLLRVAG------------TMAHEM 341
Query: 386 GHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLE 445
GHNFG HD + C + + K YI FS CS + + E
Sbjct: 342 GHNFGMFHDDYS-CKCPSTICVMDKALSFYIP------------TDFSSCSRLSYDKFFE 388
Query: 446 KKRNNCFVES-------GQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLK 498
K +NC + PICGN +VE GE+CDCG S++C + CC + + CK+K
Sbjct: 389 DKLSNCLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICC------DAKTCKIK 442
Query: 499 PGKQCSPSQGPCCTAQCAFKSKSEKCRDDSD-CAREGICNGFTALCPASDPKPNFTDCNR 557
QC + G CC +C FK CR D C +CNG + CP + N C+
Sbjct: 443 ATFQC--ALGECC-EKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHH 499
Query: 558 HTQVCINGQC 567
C+ G C
Sbjct: 500 GKGHCLMGTC 509
>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
Length = 856
Score = 117 bits (292), Expect = 5e-26
Identities = 130/530 (24%), Positives = 195/530 (36%), Gaps = 112/530 (21%)
Query: 66 AHGRHFNLRMKRDTSL----FSDEFKVETSNKVLDYDTSH---IYTGHIYGEEGSFSHGS 118
A G +F L ++++ L +++ + ++V + Y GH+ G S + S
Sbjct: 63 ATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLS 122
Query: 119 VIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSV 178
G GF Q +EP + G +GG H+V
Sbjct: 123 TCAG-LRGFFQVGSDLHLIEPLDE-------------------------GGEGG--RHAV 154
Query: 179 FERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTT------SAEKNTCQLYIQTDHLF 232
++ Q G V+ + GP R S E +LY+ D+
Sbjct: 155 YQAEHLLQTAGTCGVSD--DSLGSLLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAE 212
Query: 233 FKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIR-NISFMVKRIRINTTADEKDPTNPFR 291
F+ G+ AV ++ V +D +YQ +F + + + R + + D
Sbjct: 213 FQMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPD--------- 263
Query: 292 FPNIGVEKFLELNSEQN-----HDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEK 346
P++ +E L + Q HD+ L T DF +G A V A S G +
Sbjct: 264 -PSVTLENLLTWQARQRTRRHLHDNVQL---ITGVDFTGTTVGFARVSAMCSHSSGAVNQ 319
Query: 347 SKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTE-CTPGESK 405
D K + T AHE+GHN G HD + C E
Sbjct: 320 -----DHSKNPVGVAC-----------------TMAHEMGHNLGMDHDENVQGCRCQE-- 355
Query: 406 NLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVES-------GQP 458
+ E G IM S FS CS + LE+ ++ C + G P
Sbjct: 356 ---RFEAGRCIMAGSIGSSFP---RMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGP 409
Query: 459 ICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFK 518
+CGN VE+GE+CDCG + C++ CC C+L G QC + G CC +C K
Sbjct: 410 VCGNLFVERGEQCDCGPPEDCRNRCC------NSTTCQLAEGAQC--AHGTCC-QECKVK 460
Query: 519 SKSEKCRDDSD-CAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQC 567
E CR D C E C+G CP + N T C+ C NG C
Sbjct: 461 PAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPCS--GGYCYNGAC 508
>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
preproprotein [Homo sapiens]
Length = 813
Score = 110 bits (276), Expect = 4e-24
Identities = 105/380 (27%), Positives = 150/380 (39%), Gaps = 73/380 (19%)
Query: 205 GPELLRKKRTTSAEKNTCQLYIQTDH-LFFKYYGTREAVIAQISSHVKAIDTIYQTTDFS 263
GP+ R +R + +LYI DH LF + ++ +D + +T D
Sbjct: 196 GPQS-RGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQ 254
Query: 264 -GIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLE----LNSEQNHDDYCLAYVF 318
+ + +R R T D N + FL+ L +++ HD A +
Sbjct: 255 VALTGLEVWTERDRSRVTQDA----------NATLWAFLQWRRGLWAQRPHDS---AQLL 301
Query: 319 TDRDFDDGVLGLAWVGAP--SGSSGGIC-EKSKLYSDGKKKSLNTGIITVQNYGSHVPPK 375
T R F +GLA V + SSGG+ + S+L P
Sbjct: 302 TGRAFQGATVGLAPVEGMCRAESSGGVSTDHSEL------------------------PI 337
Query: 376 VSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLC 435
+ T AHE+GH+ G HD C + E+G +M A +G FS C
Sbjct: 338 GAAATMAHEIGHSLGLSHDPDGCCVEAAA------ESGGCVM--AAATGHPFPR-VFSAC 388
Query: 436 SIRNISQVLEKKRNNCFVESGQP-------ICGNGMVEQGEECDCGYSDQCKDECCFDAN 488
S R + K C + P +CGNG VE GEECDCG +C+D CCF N
Sbjct: 389 SRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHN 448
Query: 489 QPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDD-SDCAREGICNGFTALCPASD 547
C L+PG QC + G CC +C K CR DC C G ++ CP
Sbjct: 449 ------CSLRPGAQC--AHGDCC-VRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDV 499
Query: 548 PKPNFTDCNRHTQVCINGQC 567
+ + C R + C +G C
Sbjct: 500 YLLDGSPCARGSGYCWDGAC 519
>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
preproprotein [Homo sapiens]
Length = 787
Score = 110 bits (276), Expect = 4e-24
Identities = 105/380 (27%), Positives = 150/380 (39%), Gaps = 73/380 (19%)
Query: 205 GPELLRKKRTTSAEKNTCQLYIQTDH-LFFKYYGTREAVIAQISSHVKAIDTIYQTTDFS 263
GP+ R +R + +LYI DH LF + ++ +D + +T D
Sbjct: 196 GPQS-RGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQ 254
Query: 264 -GIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLE----LNSEQNHDDYCLAYVF 318
+ + +R R T D N + FL+ L +++ HD A +
Sbjct: 255 VALTGLEVWTERDRSRVTQDA----------NATLWAFLQWRRGLWAQRPHDS---AQLL 301
Query: 319 TDRDFDDGVLGLAWVGAP--SGSSGGIC-EKSKLYSDGKKKSLNTGIITVQNYGSHVPPK 375
T R F +GLA V + SSGG+ + S+L P
Sbjct: 302 TGRAFQGATVGLAPVEGMCRAESSGGVSTDHSEL------------------------PI 337
Query: 376 VSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLC 435
+ T AHE+GH+ G HD C + E+G +M A +G FS C
Sbjct: 338 GAAATMAHEIGHSLGLSHDPDGCCVEAAA------ESGGCVM--AAATGHPFPR-VFSAC 388
Query: 436 SIRNISQVLEKKRNNCFVESGQP-------ICGNGMVEQGEECDCGYSDQCKDECCFDAN 488
S R + K C + P +CGNG VE GEECDCG +C+D CCF N
Sbjct: 389 SRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHN 448
Query: 489 QPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDD-SDCAREGICNGFTALCPASD 547
C L+PG QC + G CC +C K CR DC C G ++ CP
Sbjct: 449 ------CSLRPGAQC--AHGDCC-VRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDV 499
Query: 548 PKPNFTDCNRHTQVCINGQC 567
+ + C R + C +G C
Sbjct: 500 YLLDGSPCARGSGYCWDGAC 519
>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
preproprotein [Homo sapiens]
Length = 863
Score = 108 bits (269), Expect = 2e-23
Identities = 108/388 (27%), Positives = 155/388 (39%), Gaps = 64/388 (16%)
Query: 194 TQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAI 253
TQ P E G +R++R E T +L I DH + Y + ++ + +
Sbjct: 189 TQKPPEHPL--GQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLL 246
Query: 254 DTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLE-----LNSEQN 308
DT + R ++ V + + ++D P + +E FL L
Sbjct: 247 DTFF--------RPLNVRVALVGLEAWT-QRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
Query: 309 HDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNY 368
HD A + T F +G+A IC +S G +T I+ V +
Sbjct: 298 HDS---AQLVTGTSFSGPTVGMA-------IQNSICSPD--FSGGVNMDHSTSILGVAS- 344
Query: 369 GSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNL-GQKENGNYIMYARATSGDKL 427
+ AHE+GH+ G HD PG S G IM A S D L
Sbjct: 345 -----------SIAHELGHSLGLDHD-----LPGNSCPCPGPAPAKTCIMEA---STDFL 385
Query: 428 NNNKFSLCSIRNISQVLEKKRNNCFVE---SGQPI---CGNGMVEQGEECDCGYSDQCKD 481
FS CS R + + L +C E S P+ CGN VE GE+CDCG+ D C D
Sbjct: 386 PGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVD 445
Query: 482 ECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDD-SDCAREGICNGFT 540
CC + C+L+PG QC+ S GPCC C + +CR DC C G +
Sbjct: 446 PCC------DSLTCQLRPGAQCA-SDGPCC-QNCQLRPSGWQCRPTRGDCDLPEFCPGDS 497
Query: 541 ALCPASDPKPNFTDCNRHTQVCINGQCA 568
+ CP + C VC++G+CA
Sbjct: 498 SQCPPDVSLGDGEPCAGGQAVCMHGRCA 525
>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
preproprotein [Homo sapiens]
Length = 862
Score = 108 bits (269), Expect = 2e-23
Identities = 108/388 (27%), Positives = 155/388 (39%), Gaps = 64/388 (16%)
Query: 194 TQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAI 253
TQ P E G +R++R E T +L I DH + Y + ++ + +
Sbjct: 189 TQKPPEHPL--GQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLL 246
Query: 254 DTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLE-----LNSEQN 308
DT + R ++ V + + ++D P + +E FL L
Sbjct: 247 DTFF--------RPLNVRVALVGLEAWT-QRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
Query: 309 HDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNY 368
HD A + T F +G+A IC +S G +T I+ V +
Sbjct: 298 HDS---AQLVTGTSFSGPTVGMA-------IQNSICSPD--FSGGVNMDHSTSILGVAS- 344
Query: 369 GSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNL-GQKENGNYIMYARATSGDKL 427
+ AHE+GH+ G HD PG S G IM A S D L
Sbjct: 345 -----------SIAHELGHSLGLDHD-----LPGNSCPCPGPAPAKTCIMEA---STDFL 385
Query: 428 NNNKFSLCSIRNISQVLEKKRNNCFVE---SGQPI---CGNGMVEQGEECDCGYSDQCKD 481
FS CS R + + L +C E S P+ CGN VE GE+CDCG+ D C D
Sbjct: 386 PGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVD 445
Query: 482 ECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDD-SDCAREGICNGFT 540
CC + C+L+PG QC+ S GPCC C + +CR DC C G +
Sbjct: 446 PCC------DSLTCQLRPGAQCA-SDGPCC-QNCQLRPSGWQCRPTRGDCDLPEFCPGDS 497
Query: 541 ALCPASDPKPNFTDCNRHTQVCINGQCA 568
+ CP + C VC++G+CA
Sbjct: 498 SQCPPDVSLGDGEPCAGGQAVCMHGRCA 525
>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
preproprotein [Homo sapiens]
Length = 838
Score = 108 bits (269), Expect = 2e-23
Identities = 108/388 (27%), Positives = 155/388 (39%), Gaps = 64/388 (16%)
Query: 194 TQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAI 253
TQ P E G +R++R E T +L I DH + Y + ++ + +
Sbjct: 189 TQKPPEHPL--GQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLL 246
Query: 254 DTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLE-----LNSEQN 308
DT + R ++ V + + ++D P + +E FL L
Sbjct: 247 DTFF--------RPLNVRVALVGLEAWT-QRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
Query: 309 HDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNY 368
HD A + T F +G+A IC +S G +T I+ V +
Sbjct: 298 HDS---AQLVTGTSFSGPTVGMA-------IQNSICSPD--FSGGVNMDHSTSILGVAS- 344
Query: 369 GSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNL-GQKENGNYIMYARATSGDKL 427
+ AHE+GH+ G HD PG S G IM A S D L
Sbjct: 345 -----------SIAHELGHSLGLDHD-----LPGNSCPCPGPAPAKTCIMEA---STDFL 385
Query: 428 NNNKFSLCSIRNISQVLEKKRNNCFVE---SGQPI---CGNGMVEQGEECDCGYSDQCKD 481
FS CS R + + L +C E S P+ CGN VE GE+CDCG+ D C D
Sbjct: 386 PGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVD 445
Query: 482 ECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDD-SDCAREGICNGFT 540
CC + C+L+PG QC+ S GPCC C + +CR DC C G +
Sbjct: 446 PCC------DSLTCQLRPGAQCA-SDGPCC-QNCQLRPSGWQCRPTRGDCDLPEFCPGDS 497
Query: 541 ALCPASDPKPNFTDCNRHTQVCINGQCA 568
+ CP + C VC++G+CA
Sbjct: 498 SQCPPDVSLGDGEPCAGGQAVCMHGRCA 525
>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
preproprotein [Homo sapiens]
Length = 839
Score = 108 bits (269), Expect = 2e-23
Identities = 108/388 (27%), Positives = 155/388 (39%), Gaps = 64/388 (16%)
Query: 194 TQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAI 253
TQ P E G +R++R E T +L I DH + Y + ++ + +
Sbjct: 189 TQKPPEHPL--GQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLL 246
Query: 254 DTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLE-----LNSEQN 308
DT + R ++ V + + ++D P + +E FL L
Sbjct: 247 DTFF--------RPLNVRVALVGLEAWT-QRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
Query: 309 HDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNY 368
HD A + T F +G+A IC +S G +T I+ V +
Sbjct: 298 HDS---AQLVTGTSFSGPTVGMA-------IQNSICSPD--FSGGVNMDHSTSILGVAS- 344
Query: 369 GSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNL-GQKENGNYIMYARATSGDKL 427
+ AHE+GH+ G HD PG S G IM A S D L
Sbjct: 345 -----------SIAHELGHSLGLDHD-----LPGNSCPCPGPAPAKTCIMEA---STDFL 385
Query: 428 NNNKFSLCSIRNISQVLEKKRNNCFVE---SGQPI---CGNGMVEQGEECDCGYSDQCKD 481
FS CS R + + L +C E S P+ CGN VE GE+CDCG+ D C D
Sbjct: 386 PGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVD 445
Query: 482 ECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDD-SDCAREGICNGFT 540
CC + C+L+PG QC+ S GPCC C + +CR DC C G +
Sbjct: 446 PCC------DSLTCQLRPGAQCA-SDGPCC-QNCQLRPSGWQCRPTRGDCDLPEFCPGDS 497
Query: 541 ALCPASDPKPNFTDCNRHTQVCINGQCA 568
+ CP + C VC++G+CA
Sbjct: 498 SQCPPDVSLGDGEPCAGGQAVCMHGRCA 525
>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
preproprotein [Homo sapiens]
Length = 772
Score = 108 bits (269), Expect = 2e-23
Identities = 108/388 (27%), Positives = 155/388 (39%), Gaps = 64/388 (16%)
Query: 194 TQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAI 253
TQ P E G +R++R E T +L I DH + Y + ++ + +
Sbjct: 189 TQKPPEHPL--GQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLL 246
Query: 254 DTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLE-----LNSEQN 308
DT + R ++ V + + ++D P + +E FL L
Sbjct: 247 DTFF--------RPLNVRVALVGLEAWT-QRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
Query: 309 HDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNY 368
HD A + T F +G+A IC +S G +T I+ V +
Sbjct: 298 HDS---AQLVTGTSFSGPTVGMA-------IQNSICSPD--FSGGVNMDHSTSILGVAS- 344
Query: 369 GSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNL-GQKENGNYIMYARATSGDKL 427
+ AHE+GH+ G HD PG S G IM A S D L
Sbjct: 345 -----------SIAHELGHSLGLDHD-----LPGNSCPCPGPAPAKTCIMEA---STDFL 385
Query: 428 NNNKFSLCSIRNISQVLEKKRNNCFVE---SGQPI---CGNGMVEQGEECDCGYSDQCKD 481
FS CS R + + L +C E S P+ CGN VE GE+CDCG+ D C D
Sbjct: 386 PGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVD 445
Query: 482 ECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDD-SDCAREGICNGFT 540
CC + C+L+PG QC+ S GPCC C + +CR DC C G +
Sbjct: 446 PCC------DSLTCQLRPGAQCA-SDGPCC-QNCQLRPSGWQCRPTRGDCDLPEFCPGDS 497
Query: 541 ALCPASDPKPNFTDCNRHTQVCINGQCA 568
+ CP + C VC++G+CA
Sbjct: 498 SQCPPDVSLGDGEPCAGGQAVCMHGRCA 525
>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
preproprotein [Homo sapiens]
Length = 814
Score = 108 bits (269), Expect = 2e-23
Identities = 108/388 (27%), Positives = 155/388 (39%), Gaps = 64/388 (16%)
Query: 194 TQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAI 253
TQ P E G +R++R E T +L I DH + Y + ++ + +
Sbjct: 189 TQKPPEHPL--GQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLL 246
Query: 254 DTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLE-----LNSEQN 308
DT + R ++ V + + ++D P + +E FL L
Sbjct: 247 DTFF--------RPLNVRVALVGLEAWT-QRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
Query: 309 HDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNY 368
HD A + T F +G+A IC +S G +T I+ V +
Sbjct: 298 HDS---AQLVTGTSFSGPTVGMA-------IQNSICSPD--FSGGVNMDHSTSILGVAS- 344
Query: 369 GSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNL-GQKENGNYIMYARATSGDKL 427
+ AHE+GH+ G HD PG S G IM A S D L
Sbjct: 345 -----------SIAHELGHSLGLDHD-----LPGNSCPCPGPAPAKTCIMEA---STDFL 385
Query: 428 NNNKFSLCSIRNISQVLEKKRNNCFVE---SGQPI---CGNGMVEQGEECDCGYSDQCKD 481
FS CS R + + L +C E S P+ CGN VE GE+CDCG+ D C D
Sbjct: 386 PGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVD 445
Query: 482 ECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDD-SDCAREGICNGFT 540
CC + C+L+PG QC+ S GPCC C + +CR DC C G +
Sbjct: 446 PCC------DSLTCQLRPGAQCA-SDGPCC-QNCQLRPSGWQCRPTRGDCDLPEFCPGDS 497
Query: 541 ALCPASDPKPNFTDCNRHTQVCINGQCA 568
+ CP + C VC++G+CA
Sbjct: 498 SQCPPDVSLGDGEPCAGGQAVCMHGRCA 525
>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
[Homo sapiens]
Length = 906
Score = 100 bits (248), Expect = 6e-21
Identities = 128/541 (23%), Positives = 194/541 (35%), Gaps = 102/541 (18%)
Query: 53 VSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEF---KVETSNKVLDYDTSH--IYTGHI 107
++H DQ A G F L + + L S E+ +E K ++ Y GHI
Sbjct: 83 LTHVDQ-ASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHI 141
Query: 108 YGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKY 167
G SF S G G T+ +EP E FHSV
Sbjct: 142 RGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVY------------ 188
Query: 168 GPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQ 227
+ + S+ + ++Q + I + + +L R R E +L I
Sbjct: 189 --KSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIV 246
Query: 228 TDHLFFKYYGTREAVI---AQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEK 284
DHL FK + R +V+ S V D IY+ + + + + T A +
Sbjct: 247 NDHLMFKKH--RLSVVHTNTYAKSVVNMADLIYKD-------QLKTRIVLVAMETWATD- 296
Query: 285 DPTNPFRF---PNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSG 341
N F P I + +F++ + + ++F+ F+ G A++G
Sbjct: 297 ---NKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIG------- 346
Query: 342 GICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTP 401
GIC S L G + T ++ V T A + HN G D +
Sbjct: 347 GIC--SLLKGGGVNEFGKTDLMAV--------------TLAQSLAHNIGIISDK-RKLAS 389
Query: 402 GESK------NLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVES 455
GE K + G Y+ KF+ C+I L C
Sbjct: 390 GECKCEDTWSGCIMGDTGYYLP------------KKFTQCNIEEYHDFLNSGGGACLFNK 437
Query: 456 GQ-----PICGNGMVEQGEECDCGYSDQC---KDECCFDANQPEGRKCKLKPGKQCSPSQ 507
P CGNG +E GEECDCG +C ECC +KC L QC S
Sbjct: 438 PSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--------KKCTLTQDSQC--SD 487
Query: 508 GPCCTAQCAFKSKSEKCRDD-SDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQ 566
G CC +C F+ CR+ +DC C+G ++ C + K + C+ +C G+
Sbjct: 488 GLCC-KKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546
Query: 567 C 567
C
Sbjct: 547 C 547
>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
[Homo sapiens]
Length = 899
Score = 100 bits (248), Expect = 6e-21
Identities = 128/541 (23%), Positives = 194/541 (35%), Gaps = 102/541 (18%)
Query: 53 VSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEF---KVETSNKVLDYDTSH--IYTGHI 107
++H DQ A G F L + + L S E+ +E K ++ Y GHI
Sbjct: 83 LTHVDQ-ASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHI 141
Query: 108 YGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKY 167
G SF S G G T+ +EP E FHSV
Sbjct: 142 RGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVY------------ 188
Query: 168 GPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQ 227
+ + S+ + ++Q + I + + +L R R E +L I
Sbjct: 189 --KSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIV 246
Query: 228 TDHLFFKYYGTREAVI---AQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEK 284
DHL FK + R +V+ S V D IY+ + + + + T A +
Sbjct: 247 NDHLMFKKH--RLSVVHTNTYAKSVVNMADLIYKD-------QLKTRIVLVAMETWATD- 296
Query: 285 DPTNPFRF---PNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSG 341
N F P I + +F++ + + ++F+ F+ G A++G
Sbjct: 297 ---NKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIG------- 346
Query: 342 GICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTP 401
GIC S L G + T ++ V T A + HN G D +
Sbjct: 347 GIC--SLLKGGGVNEFGKTDLMAV--------------TLAQSLAHNIGIISDK-RKLAS 389
Query: 402 GESK------NLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVES 455
GE K + G Y+ KF+ C+I L C
Sbjct: 390 GECKCEDTWSGCIMGDTGYYLP------------KKFTQCNIEEYHDFLNSGGGACLFNK 437
Query: 456 GQ-----PICGNGMVEQGEECDCGYSDQC---KDECCFDANQPEGRKCKLKPGKQCSPSQ 507
P CGNG +E GEECDCG +C ECC +KC L QC S
Sbjct: 438 PSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--------KKCTLTQDSQC--SD 487
Query: 508 GPCCTAQCAFKSKSEKCRDD-SDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQ 566
G CC +C F+ CR+ +DC C+G ++ C + K + C+ +C G+
Sbjct: 488 GLCC-KKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546
Query: 567 C 567
C
Sbjct: 547 C 547
>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
[Homo sapiens]
Length = 823
Score = 100 bits (248), Expect = 6e-21
Identities = 128/541 (23%), Positives = 194/541 (35%), Gaps = 102/541 (18%)
Query: 53 VSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEF---KVETSNKVLDYDTSH--IYTGHI 107
++H DQ A G F L + + L S E+ +E K ++ Y GHI
Sbjct: 83 LTHVDQ-ASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHI 141
Query: 108 YGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKY 167
G SF S G G T+ +EP E FHSV
Sbjct: 142 RGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVY------------ 188
Query: 168 GPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQ 227
+ + S+ + ++Q + I + + +L R R E +L I
Sbjct: 189 --KSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIV 246
Query: 228 TDHLFFKYYGTREAVI---AQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEK 284
DHL FK + R +V+ S V D IY+ + + + + T A +
Sbjct: 247 NDHLMFKKH--RLSVVHTNTYAKSVVNMADLIYKD-------QLKTRIVLVAMETWATD- 296
Query: 285 DPTNPFRF---PNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSG 341
N F P I + +F++ + + ++F+ F+ G A++G
Sbjct: 297 ---NKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIG------- 346
Query: 342 GICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTP 401
GIC S L G + T ++ V T A + HN G D +
Sbjct: 347 GIC--SLLKGGGVNEFGKTDLMAV--------------TLAQSLAHNIGIISDK-RKLAS 389
Query: 402 GESK------NLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVES 455
GE K + G Y+ KF+ C+I L C
Sbjct: 390 GECKCEDTWSGCIMGDTGYYLP------------KKFTQCNIEEYHDFLNSGGGACLFNK 437
Query: 456 GQ-----PICGNGMVEQGEECDCGYSDQC---KDECCFDANQPEGRKCKLKPGKQCSPSQ 507
P CGNG +E GEECDCG +C ECC +KC L QC S
Sbjct: 438 PSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--------KKCTLTQDSQC--SD 487
Query: 508 GPCCTAQCAFKSKSEKCRDD-SDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQ 566
G CC +C F+ CR+ +DC C+G ++ C + K + C+ +C G+
Sbjct: 488 GLCC-KKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546
Query: 567 C 567
C
Sbjct: 547 C 547
>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
[Homo sapiens]
Length = 870
Score = 100 bits (248), Expect = 6e-21
Identities = 128/541 (23%), Positives = 194/541 (35%), Gaps = 102/541 (18%)
Query: 53 VSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEF---KVETSNKVLDYDTSH--IYTGHI 107
++H DQ A G F L + + L S E+ +E K ++ Y GHI
Sbjct: 83 LTHVDQ-ASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHI 141
Query: 108 YGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKY 167
G SF S G G T+ +EP E FHSV
Sbjct: 142 RGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVY------------ 188
Query: 168 GPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQ 227
+ + S+ + ++Q + I + + +L R R E +L I
Sbjct: 189 --KSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIV 246
Query: 228 TDHLFFKYYGTREAVI---AQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEK 284
DHL FK + R +V+ S V D IY+ + + + + T A +
Sbjct: 247 NDHLMFKKH--RLSVVHTNTYAKSVVNMADLIYKD-------QLKTRIVLVAMETWATD- 296
Query: 285 DPTNPFRF---PNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSG 341
N F P I + +F++ + + ++F+ F+ G A++G
Sbjct: 297 ---NKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIG------- 346
Query: 342 GICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTP 401
GIC S L G + T ++ V T A + HN G D +
Sbjct: 347 GIC--SLLKGGGVNEFGKTDLMAV--------------TLAQSLAHNIGIISDK-RKLAS 389
Query: 402 GESK------NLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVES 455
GE K + G Y+ KF+ C+I L C
Sbjct: 390 GECKCEDTWSGCIMGDTGYYLP------------KKFTQCNIEEYHDFLNSGGGACLFNK 437
Query: 456 GQ-----PICGNGMVEQGEECDCGYSDQC---KDECCFDANQPEGRKCKLKPGKQCSPSQ 507
P CGNG +E GEECDCG +C ECC +KC L QC S
Sbjct: 438 PSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--------KKCTLTQDSQC--SD 487
Query: 508 GPCCTAQCAFKSKSEKCRDD-SDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQ 566
G CC +C F+ CR+ +DC C+G ++ C + K + C+ +C G+
Sbjct: 488 GLCC-KKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546
Query: 567 C 567
C
Sbjct: 547 C 547
>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
[Homo sapiens]
Length = 859
Score = 100 bits (248), Expect = 6e-21
Identities = 128/541 (23%), Positives = 194/541 (35%), Gaps = 102/541 (18%)
Query: 53 VSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEF---KVETSNKVLDYDTSH--IYTGHI 107
++H DQ A G F L + + L S E+ +E K ++ Y GHI
Sbjct: 83 LTHVDQ-ASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHI 141
Query: 108 YGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKY 167
G SF S G G T+ +EP E FHSV
Sbjct: 142 RGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVY------------ 188
Query: 168 GPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQ 227
+ + S+ + ++Q + I + + +L R R E +L I
Sbjct: 189 --KSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIV 246
Query: 228 TDHLFFKYYGTREAVI---AQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEK 284
DHL FK + R +V+ S V D IY+ + + + + T A +
Sbjct: 247 NDHLMFKKH--RLSVVHTNTYAKSVVNMADLIYKD-------QLKTRIVLVAMETWATD- 296
Query: 285 DPTNPFRF---PNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSG 341
N F P I + +F++ + + ++F+ F+ G A++G
Sbjct: 297 ---NKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIG------- 346
Query: 342 GICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTP 401
GIC S L G + T ++ V T A + HN G D +
Sbjct: 347 GIC--SLLKGGGVNEFGKTDLMAV--------------TLAQSLAHNIGIISDK-RKLAS 389
Query: 402 GESK------NLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVES 455
GE K + G Y+ KF+ C+I L C
Sbjct: 390 GECKCEDTWSGCIMGDTGYYLP------------KKFTQCNIEEYHDFLNSGGGACLFNK 437
Query: 456 GQ-----PICGNGMVEQGEECDCGYSDQC---KDECCFDANQPEGRKCKLKPGKQCSPSQ 507
P CGNG +E GEECDCG +C ECC +KC L QC S
Sbjct: 438 PSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--------KKCTLTQDSQC--SD 487
Query: 508 GPCCTAQCAFKSKSEKCRDD-SDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQ 566
G CC +C F+ CR+ +DC C+G ++ C + K + C+ +C G+
Sbjct: 488 GLCC-KKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546
Query: 567 C 567
C
Sbjct: 547 C 547
>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
sapiens]
Length = 918
Score = 99.8 bits (247), Expect = 8e-21
Identities = 63/196 (32%), Positives = 88/196 (44%), Gaps = 27/196 (13%)
Query: 380 TFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRN 439
T AHE+GHNFG HDS C+ + +G IM A +G F+ C+ R
Sbjct: 342 TMAHEMGHNFGMTHDSADCCSASAA-------DGGCIM--AAATGHPFPK-VFNGCNRRE 391
Query: 440 ISQVLEKKRNNCFVES-------GQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEG 492
+ + L+ C G CGNG +E GEECDCG ++C + CC +N
Sbjct: 392 LDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASN---- 447
Query: 493 RKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDS-DCAREGICNGFTALCPASDPKPN 551
C L+PG +C + G CC QC + CR+ + C C G + CP + + +
Sbjct: 448 --CTLRPGAEC--AHGSCC-HQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMD 502
Query: 552 FTDCNRHTQVCINGQC 567
T C C NG C
Sbjct: 503 GTPCEGGQAYCYNGMC 518
>gi|7656861 a disintegrin and metalloprotease domain 18
preproprotein [Homo sapiens]
Length = 739
Score = 98.2 bits (243), Expect = 2e-20
Identities = 124/532 (23%), Positives = 202/532 (37%), Gaps = 121/532 (22%)
Query: 68 GRHFNLRMKRDTSLFSDEFKVETSNK------VLDYDTSHI-YTGHIYGEEGSFSHGSVI 120
G+ + L + + S F V T N+ V Y H Y G+ SF S+
Sbjct: 53 GQPYTLHLGKQ-SFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSIC 111
Query: 121 DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDD---------INYPHKYGPQG 171
G GF+Q ++ +EP E + F +IY + +NY H
Sbjct: 112 SG-LRGFLQFENISYGIEPVESSAR-----FEHIIYQMKNNDPNVSILAVNYSH------ 159
Query: 172 GCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHL 231
++++ + Y+ +P N +LL + ++YI +
Sbjct: 160 ------IWQKDQPYK---------VPLNSQIKNLSKLLPQY---------LEIYIIVEKA 195
Query: 232 FFKYYGTREAVIAQ-ISSHVKAIDTIYQTTDFSGI-RNISFMVKRIRINTTADEKDPTNP 289
+ Y G+ + Q I + ++T++ + I ++ +I+T+ D D
Sbjct: 196 LYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNENQISTSGDADDI--- 252
Query: 290 FRFPNIGVEKFLELNSE----QNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICE 345
+++FL + + HD +AY+ R +VGA G +C
Sbjct: 253 -------LQRFLAWKRDYLILRPHD---IAYLLVYRKHPK------YVGATF--PGTVCN 294
Query: 346 KSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESK 405
KS Y G + Y + + + A +G N G +D T+C +
Sbjct: 295 KS--YDAG-----------IAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQCFCLRAT 341
Query: 406 NLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCF--------VESGQ 457
+ E A + SG K+ FS CS+ + + K C + Q
Sbjct: 342 CIMNHE-------AVSASGRKI----FSNCSMHDYRYFVSKFETKCLQKLSNLQPLHQNQ 390
Query: 458 PICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAF 517
P+CGNG++E EECDCG ++C+ + C D N CKLK +C GPCCT++C
Sbjct: 391 PVCGNGILESNEECDCGNKNECQFKKCCDYN-----TCKLKGSVKC--GSGPCCTSKCEL 443
Query: 518 KSKSEKCRD--DSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQC 567
CR D +C CNG ++ C N C T C NGQC
Sbjct: 444 SIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQC 495
>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
[Homo sapiens]
Length = 738
Score = 96.3 bits (238), Expect = 9e-20
Identities = 74/235 (31%), Positives = 97/235 (41%), Gaps = 38/235 (16%)
Query: 374 PKVSHITFAHEVGHNFGSPHDS---GTECTPGESKNLGQKENGNYIMYARATSGDKLNNN 430
P + +T AHE+GHNFG HD+ G C K G IM A +
Sbjct: 341 PLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEK-------GGCIMNASTGYPFPM--- 390
Query: 431 KFSLCSIRNISQVLEKKRNNCFVES-------GQPICGNGMVEQGEECDCGYSDQCKDEC 483
FS CS +++ LEK C G CGN VE+GEECDCG ++C + C
Sbjct: 391 VFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRC 450
Query: 484 CFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSD-CAREGICNGFTAL 542
C C LKP C + G CC C K CRD S+ C C G +
Sbjct: 451 C------NATTCTLKPDAVC--AHGLCC-EDCQLKPAGTACRDSSNSCDLPEFCTGASPH 501
Query: 543 CPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVC 597
CPA N + H+ ++G C IC+ + E C + G K +C
Sbjct: 502 CPA-----NVYLHDGHSCQDVDGYCYNGICQTH---EQQCVTLWGPGAKPAPGIC 548
>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
[Homo sapiens]
Length = 909
Score = 96.3 bits (238), Expect = 9e-20
Identities = 74/235 (31%), Positives = 97/235 (41%), Gaps = 38/235 (16%)
Query: 374 PKVSHITFAHEVGHNFGSPHDS---GTECTPGESKNLGQKENGNYIMYARATSGDKLNNN 430
P + +T AHE+GHNFG HD+ G C K G IM A +
Sbjct: 341 PLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEK-------GGCIMNASTGYPFPM--- 390
Query: 431 KFSLCSIRNISQVLEKKRNNCFVES-------GQPICGNGMVEQGEECDCGYSDQCKDEC 483
FS CS +++ LEK C G CGN VE+GEECDCG ++C + C
Sbjct: 391 VFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRC 450
Query: 484 CFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSD-CAREGICNGFTAL 542
C C LKP C + G CC C K CRD S+ C C G +
Sbjct: 451 C------NATTCTLKPDAVC--AHGLCC-EDCQLKPAGTACRDSSNSCDLPEFCTGASPH 501
Query: 543 CPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVC 597
CPA N + H+ ++G C IC+ + E C + G K +C
Sbjct: 502 CPA-----NVYLHDGHSCQDVDGYCYNGICQTH---EQQCVTLWGPGAKPAPGIC 548
>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
sapiens]
Length = 832
Score = 93.2 bits (230), Expect = 8e-19
Identities = 130/562 (23%), Positives = 207/562 (36%), Gaps = 99/562 (17%)
Query: 28 YIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEF- 86
YI Y+V +HQ+ H Q A G F L + + L S ++
Sbjct: 120 YINQDSESPYHVLDTKARHQQKHNKAVHLAQ-ASFQIEAFGSKFILDLILNNGLLSSDYV 178
Query: 87 KVETSNKVLDYDTSH---IYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERY 143
++ N Y Y G I G + S S +G G + + +EP E
Sbjct: 179 EIHYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNG-LHGMFEDDTFVYMIEPLE-- 235
Query: 144 IKDRTLPFHSVIYHEDDINYPHKY-----GPQGGCADHSVFERMRKYQMTGVEEVTQIPQ 198
+++ E PH G + ER ++ + E+ + +
Sbjct: 236 ----------LVHDEKSTGRPHIIQKTLAGQYSKQMKNLTMERGDQWPF--LSELQWLKR 283
Query: 199 EEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQIS-SHVKAIDTIY 257
+ A N R E +L I DH +K + + A + S V +D+IY
Sbjct: 284 RKRAVN------PSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIY 337
Query: 258 QTTDFSGIRNISFMVKRIRINTTADEKD-PTNPFRFPNIGVEKFLELNSE-QNHDDYCLA 315
+ N ++ + T D+ D TNP + + +F + + H D
Sbjct: 338 KEQ-----LNTRVVLVAVETWTEKDQIDITTNPVQM----LHEFSKYRQRIKQHAD--AV 386
Query: 316 YVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPK 375
++ + F L++ G G+C +++ + V YG +P
Sbjct: 387 HLISRVTFHYKRSSLSYFG-------GVCSRTRG-------------VGVNEYG--LPMA 424
Query: 376 VSHITFAHEVGHNFG---SPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKF 432
V+ + + + N G P +C ES G IM S ++ KF
Sbjct: 425 VAQV-LSQSLAQNLGIQWEPSSRKPKCDCTESW-------GGCIMEETGVS----HSRKF 472
Query: 433 SLCSIRNISQVLEKKRNNCFVESGQPI-----CGNGMVEQGEECDCGYSDQCKDECCFDA 487
S CSI L++ C + CGNG VE GEECDCG+ +C CC
Sbjct: 473 SKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEAGEECDCGFHVECYGLCC--- 529
Query: 488 NQPEGRKCKLKPGKQCSPSQGPCC-TAQCAFKSKSEKCRDD-SDCAREGICNGFTALCPA 545
+KC L G C S GPCC C F+ + +CRD ++C C G + CP
Sbjct: 530 -----KKCSLSNGAHC--SDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPP 582
Query: 546 SDPKPNFTDCNRHTQVCINGQC 567
+ K + CN++ C NG+C
Sbjct: 583 NLHKQDGYACNQNQGRCYNGEC 604
>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
sapiens]
Length = 754
Score = 90.5 bits (223), Expect = 5e-18
Identities = 58/194 (29%), Positives = 80/194 (41%), Gaps = 31/194 (15%)
Query: 382 AHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNIS 441
AH++GHN G HD P +G +M S + KFS CS
Sbjct: 334 AHQLGHNLGMQHDEFPCTCP----------SGKCVM----DSDGSIPALKFSKCSQNQYH 379
Query: 442 QVLEKKRNNCFVESGQP-------ICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRK 494
Q L+ + C + P CGN +++GEECDCG + +C + CC +
Sbjct: 380 QYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDCGPAQECTNPCC------DAHT 433
Query: 495 CKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSD-CAREGICNGFTALCPASDPKPNFT 553
C LKPG C ++G CC + C K CR D C +C G + CP + N
Sbjct: 434 CVLKPGFTC--AEGECCES-CQIKKAGSICRPAKDECDFPEMCTGHSPACPKDQFRVNGF 490
Query: 554 DCNRHTQVCINGQC 567
C C G+C
Sbjct: 491 PCKNSEGYCFMGKC 504
>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
sapiens]
Length = 735
Score = 85.9 bits (211), Expect = 1e-16
Identities = 51/162 (31%), Positives = 71/162 (43%), Gaps = 27/162 (16%)
Query: 432 FSLCSIRNISQVLEKKRNNCFVESG--------QPICGNGMVEQGEECDCGYSDQCK--- 480
FS CS + + + K+++ C Q +CGN +E GEECDCG C
Sbjct: 351 FSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIG 410
Query: 481 DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDD-SDCAREGICNGF 539
+ CC A C+ K G C ++GPCC C F SK CR +C CNG
Sbjct: 411 ETCCDIAT------CRFKAGSNC--AEGPCC-ENCLFMSKERMCRPSFEECDLPEYCNGS 461
Query: 540 TALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECT 581
+A CP + C + +CI+G C G ++CT
Sbjct: 462 SASCPENHYVQTGHPCGLNQWICIDGVCMS------GDKQCT 497
>gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo
sapiens]
Length = 769
Score = 84.7 bits (208), Expect = 3e-16
Identities = 114/492 (23%), Positives = 175/492 (35%), Gaps = 106/492 (21%)
Query: 103 YTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDIN 162
Y G + G SF+ S G G T+ VEP E
Sbjct: 135 YQGKLRGNPHSFAALSTCQG-LHGVFSDGNLTYIVEPQE--------------------- 172
Query: 163 YPHKYGPQGGCADHSVFERMRKYQMTGVEE---VTQIPQEEHAANGPELLRKKR------ 213
+G G H ++ G E + +P + N P L RK++
Sbjct: 173 VAGPWGAPQGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSAPPNRPRLRRKRQVRRGHP 232
Query: 214 TTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQIS---SHVKAIDTIYQTTDFSGIRNISF 270
T +E +L + DH F+ R++V+ + S V D IY+ ++
Sbjct: 233 TVHSETKYVELIVINDHQLFEQM--RQSVVLTSNFAKSVVNLADVIYK-------EQLNT 283
Query: 271 MVKRIRINTTAD-EKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLG 329
+ + + T AD +K + + + E + ++F+ R F G
Sbjct: 284 RIVLVAMETWADGDKIQVQDDLLETLA--RLMVYRREGLPEPSDATHLFSGRTFQSTSSG 341
Query: 330 LAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNF 389
A+VG GIC S + G + N G + V T A +G N
Sbjct: 342 AAYVG-------GICSLS--HGGGVNEYGNMGAMAV--------------TLAQTLGQNL 378
Query: 390 G----SPHDSGTECT-PGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVL 444
G S +C P ++ G Y+ KFS CSI +Q L
Sbjct: 379 GMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYLP------------RKFSRCSIDEYNQFL 426
Query: 445 EKKRNNCFVES-----GQPICGNGMVEQGEECDCGYSDQCK---DECCFDANQPEGRKCK 496
++ +C P CGNG VE GEECDCG +C CC +KC
Sbjct: 427 QEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCC--------KKCT 478
Query: 497 LKPGKQCSPSQGPCCTAQCAFKSKSEKCRDD-SDCAREGICNGFTALCPASDPKPNFTDC 555
L C S G CC +C ++ + CR+ ++C C G ++ CP + K + C
Sbjct: 479 LTHDAMC--SDGLCC-RRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYC 535
Query: 556 NRHTQVCINGQC 567
+ C G+C
Sbjct: 536 DHEQGRCYGGRC 547
>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
sapiens]
Length = 790
Score = 81.3 bits (199), Expect = 3e-15
Identities = 81/291 (27%), Positives = 118/291 (40%), Gaps = 69/291 (23%)
Query: 315 AYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPP 374
A+++ R ++D LAW S G +C S Y+ L+T I+ +
Sbjct: 293 AHLYLQRKYNDA---LAW------SFGKVC--SLEYAGSVSTLLDTNILAPATWS----- 336
Query: 375 KVSHITFAHEVGHNFGSPHDSG-TECTPGESKNLGQKENG----NYIMYAR-ATSGDKLN 428
AHE+GH G HD +C + +G G +YI + + +SG
Sbjct: 337 -------AHELGHAVGMSHDEQYCQCRGRLNCIMGSGRTGFSNCSYISFFKHISSGATCL 389
Query: 429 NNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQC-KDECCFDA 487
NN I + VL++ CGN +VE EECDCG +++C KD CC
Sbjct: 390 NN------IPGLGYVLKR-------------CGNKIVEDNEECDCGSTEECQKDRCC--- 427
Query: 488 NQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDD-SDCAREGICNGFTALCPAS 546
CKL+PG C S G CC C F+ CR + ++C C+G ++ CP
Sbjct: 428 ----QSNCKLQPGANC--SIGLCC-HDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPND 480
Query: 547 DPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVC 597
K + T C G+C C ++ C S G D E C
Sbjct: 481 VYKQDGTPCK------YEGRCFRKGCRSRYMQ---CQSIFGPDAMEAPSEC 522
>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
sapiens]
Length = 776
Score = 76.6 bits (187), Expect = 8e-14
Identities = 127/550 (23%), Positives = 197/550 (35%), Gaps = 108/550 (19%)
Query: 68 GRHFNLRMKRDTSLFSDEFKV--ETSNKVLDYDTSHI-----YTGHIYGEEGSFSHGSVI 120
G+ + + M+ + LF+ V T L D I Y G++ G S S
Sbjct: 119 GQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTC 178
Query: 121 DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE 180
G F G +Q + ++P + F ++Y D +D + F
Sbjct: 179 SGGFLGMLQINDLVYEIKPISV-----SATFEHLVYKID--------------SDDTQFP 219
Query: 181 RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTS--AEKNTCQLYIQTDHLFFKYYGT 238
MR G+ E Q E + L++ + +L + D++ + + +
Sbjct: 220 PMR----CGLTEEKIAHQMELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQS 275
Query: 239 REAVIA-QISSHVKAIDTIYQTTDFSGI-RNISFMVKRIRINTTADEKDPTNPFRFPNIG 296
+ ++ + V +D+ Y + I I + T+ D + F
Sbjct: 276 NATTVQHEVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDF-----S 330
Query: 297 VEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKK 356
+ K LN+ HD +A++F +D LG+A+V GIC+
Sbjct: 331 IWKNYNLNNRLQHD---VAHLFI-KDTQGMKLGVAYVK-------GICQNP--------- 370
Query: 357 SLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYI 416
NTG+ ++ V IT HE+GHN G HD T+ E + I
Sbjct: 371 -FNTGVDVFEDNRL----VVFAITLGHELGHNLGMQHD--TQWCVCELQWC--------I 415
Query: 417 MYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQP-------ICGNGMVEQGE 469
M+A K +N ++ IS L C P CGN +VE+GE
Sbjct: 416 MHAYRKVTTKFSNCSYAQYWDSTISSGL------CIQPPPYPGNIFRLKYCGNLVVEEGE 469
Query: 470 ECDCGYSDQC-KDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDD- 527
ECDCG QC KD CC C L PG C + G CC C F CR
Sbjct: 470 ECDCGTIRQCAKDPCCL-------LNCTLHPGAAC--AFGICC-KDCKFLPSGTLCRQQV 519
Query: 528 SDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDG 587
+C CNG + CP + CN +N C C + ++ C G
Sbjct: 520 GECDLPEWCNGTSHQCPDDVYVQDGISCN------VNAFCYEKTCNNHDIQ---CKEIFG 570
Query: 588 KDDKELCHVC 597
+D + C
Sbjct: 571 QDARSASQSC 580
>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 73.9 bits (180), Expect = 5e-13
Identities = 52/168 (30%), Positives = 72/168 (42%), Gaps = 21/168 (12%)
Query: 379 ITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIR 438
I AH +GHN G HD T C + + + + N ++ + GD F ++
Sbjct: 328 IAVAHHLGHNLGMNHDEDT-CRCSQPRCIMHEGNPPITKFSNCSYGD------FWEYTVE 380
Query: 439 NISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQC-KDECCFDANQPEGRKCKL 497
+LE + CGNG+VE+GEECDCG C KD CC C L
Sbjct: 381 RTKCLLETVHTKDIFNVKR--CGNGVVEEGEECDCGPLKHCAKDPCCLS-------NCTL 431
Query: 498 KPGKQCSPSQGPCCTAQCAFKSKSEKCRDD-SDCAREGICNGFTALCP 544
G C + G CC C F + CR + ++C CNG + CP
Sbjct: 432 TDGSTC--AFGLCC-KDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCP 476
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,756,048
Number of Sequences: 37866
Number of extensions: 1774229
Number of successful extensions: 7318
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 142
Number of HSP's that attempted gapping in prelim test: 6707
Number of HSP's gapped (non-prelim): 597
length of query: 748
length of database: 18,247,518
effective HSP length: 110
effective length of query: 638
effective length of database: 14,082,258
effective search space: 8984480604
effective search space used: 8984480604
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.