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Search of human proteins with 4506145
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]
(247 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506145 protease, serine, 1 preproprotein [Homo sapiens] 513 e-146
gi|4506147 protease, serine, 2 preproprotein [Homo sapiens] 461 e-130
gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens] 451 e-127
gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens] 432 e-121
gi|20302143 kallikrein-related peptidase 15 isoform 4 preproprot... 219 2e-57
gi|117306176 kallikrein-related peptidase 5 preproprotein [Homo ... 219 2e-57
gi|117306172 kallikrein-related peptidase 5 preproprotein [Homo ... 219 2e-57
gi|6912644 kallikrein-related peptidase 5 preproprotein [Homo sa... 219 2e-57
gi|91823048 kallikrein 14 preproprotein [Homo sapiens] 217 7e-57
gi|61744424 kallikrein-related peptidase 6 isoform A preproprote... 213 2e-55
gi|4506155 kallikrein-related peptidase 6 isoform A preproprotei... 213 2e-55
gi|4504875 kallikrein 1 preproprotein [Homo sapiens] 211 6e-55
gi|21618357 kallikrein 11 isoform 2 precursor [Homo sapiens] 211 6e-55
gi|209862865 kallikrein 11 isoform 1 preproprotein [Homo sapiens] 210 8e-55
gi|5803199 kallikrein 11 isoform 1 preproprotein [Homo sapiens] 210 8e-55
gi|21464127 kallikrein 8 isoform 2 [Homo sapiens] 210 8e-55
gi|6005844 kallikrein 8 isoform 1 preproprotein [Homo sapiens] 210 8e-55
gi|5031829 kallikrein 2, prostatic isoform 1 [Homo sapiens] 208 4e-54
gi|11496281 kallikrein 13 precursor [Homo sapiens] 204 7e-53
gi|4502173 prostate specific antigen isoform 1 preproprotein [Ho... 201 4e-52
gi|21327705 stratum corneum chymotryptic enzyme preproprotein [H... 199 2e-51
gi|4826950 stratum corneum chymotryptic enzyme preproprotein [Ho... 199 2e-51
gi|22208987 kallikrein 12 isoform 2 [Homo sapiens] 191 5e-49
gi|29366812 kallikrein-related peptidase 9 [Homo sapiens] 188 3e-48
gi|9665236 kallikrein 12 isoform 1 [Homo sapiens] 182 2e-46
gi|89142741 kallikrein-related peptidase 4 preproprotein [Homo s... 181 5e-46
gi|33667063 transmembrane protease, serine 9 [Homo sapiens] 178 3e-45
gi|117422433 kallikrein-related peptidase 10 preproprotein [Homo... 177 6e-45
gi|22208984 kallikrein-related peptidase 10 preproprotein [Homo ... 177 6e-45
gi|22208982 kallikrein-related peptidase 10 preproprotein [Homo ... 177 6e-45
>gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]
Length = 247
Score = 513 bits (1322), Expect = e-146
Identities = 247/247 (100%), Positives = 247/247 (100%)
Query: 1 MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS 60
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
Sbjct: 1 MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS 60
Query: 61 AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN 120
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
Sbjct: 61 AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN 120
Query: 121 ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT 180
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
Sbjct: 121 ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT 180
Query: 181 SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK 240
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
Sbjct: 181 SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK 240
Query: 241 NTIAANS 247
NTIAANS
Sbjct: 241 NTIAANS 247
>gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]
Length = 247
Score = 461 bits (1186), Expect = e-130
Identities = 221/247 (89%), Positives = 236/247 (95%)
Query: 1 MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS 60
MN LLILTFVAAA+AAPFDDDDKIVGGY CEENSVPYQVSLNSGYHFCGGSLI+EQWVVS
Sbjct: 1 MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNSGYHFCGGSLISEQWVVS 60
Query: 61 AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN 120
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHP+Y+ +TL+NDI+LIKLSS AVIN
Sbjct: 61 AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVIN 120
Query: 121 ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT 180
+RVS ISLPTAPPA GT+ LISGWGNT SSGADYPDELQCLDAPVLSQA+CEASYPGKIT
Sbjct: 121 SRVSAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYPGKIT 180
Query: 181 SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK 240
+NMFCVGFLEGGKDSCQGDSGGPVV NG+LQG+VSWG GCAQKN+PGVYTKVYNYV WIK
Sbjct: 181 NNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNYVDWIK 240
Query: 241 NTIAANS 247
+TIAANS
Sbjct: 241 DTIAANS 247
>gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]
Length = 247
Score = 451 bits (1160), Expect = e-127
Identities = 214/247 (86%), Positives = 231/247 (93%)
Query: 1 MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS 60
MNP LIL FV AA+A PFDDDDKIVGGY CEENS+PYQVSLNSG HFCGGSLI+EQWVVS
Sbjct: 1 MNPFLILAFVGAAVAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVS 60
Query: 61 AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN 120
A HCYK+RIQVRLGEHNI+VLEGNEQFINAAKIIRHP+Y+R TL+NDIMLIKLSS AVIN
Sbjct: 61 AAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVIN 120
Query: 121 ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT 180
ARVSTISLPTAPPA GT+CLISGWGNT S GADYPDEL+CLDAPVL+QA+C+ASYPGKIT
Sbjct: 121 ARVSTISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKIT 180
Query: 181 SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK 240
++MFCVGFLEGGKDSCQ DSGGPVVCNGQLQGVVSWG GCA KN+PGVYTKVYNYV WIK
Sbjct: 181 NSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWKNRPGVYTKVYNYVDWIK 240
Query: 241 NTIAANS 247
+TIAANS
Sbjct: 241 DTIAANS 247
>gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]
Length = 304
Score = 432 bits (1112), Expect = e-121
Identities = 204/234 (87%), Positives = 221/234 (94%)
Query: 14 LAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRL 73
+A PFDDDDKIVGGY CEENS+PYQVSLNSG HFCGGSLI+EQWVVSA HCYK+RIQVRL
Sbjct: 71 VAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRL 130
Query: 74 GEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPP 133
GEHNI+VLEGNEQFINAAKIIRHP+Y+R TL+NDIMLIKLSS AVINARVSTISLPTAPP
Sbjct: 131 GEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTAPP 190
Query: 134 ATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGK 193
A GT+CLISGWGNT S GADYPDEL+CLDAPVL+QA+C+ASYPGKIT++MFCVGFLEGGK
Sbjct: 191 AAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGFLEGGK 250
Query: 194 DSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS 247
DSCQ DSGGPVVCNGQLQGVVSWG GCA KN+PGVYTKVYNYV WIK+TIAANS
Sbjct: 251 DSCQRDSGGPVVCNGQLQGVVSWGHGCAWKNRPGVYTKVYNYVDWIKDTIAANS 304
>gi|20302143 kallikrein-related peptidase 15 isoform 4 preproprotein
[Homo sapiens]
Length = 256
Score = 219 bits (558), Expect = 2e-57
Identities = 111/255 (43%), Positives = 155/255 (60%), Gaps = 14/255 (5%)
Query: 4 LLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSL-NSGYHFCGGSLINEQWVVSAG 62
LL L+F+ A+ AA D DK++ G C +S P+QV+L G CG SLI+ WV+SA
Sbjct: 4 LLTLSFLLASTAA--QDGDKLLEGDECAPHSQPWQVALYERGRFNCGASLISPHWVLSAA 61
Query: 63 HCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINAR 122
HC ++VRLGEHN+ +G EQ +++I HP+Y+ ++ NDIML++L A +N +
Sbjct: 62 HCQSRFMRVRLGEHNLRKRDGPEQLRTTSRVIPHPRYEARSHRNDIMLLRLVQPARLNPQ 121
Query: 123 VSTISLPTAPPATGTKCLISGWG----------NTASSGADYPDELQCLDAPVLSQAKCE 172
V LPT P G C++SGWG + S PD L C + ++S C+
Sbjct: 122 VRPAVLPTRCPHPGEACVVSGWGLVSHNEPGTAGSPRSQVSLPDTLHCANISIISDTSCD 181
Query: 173 ASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGD-GCAQKNKPGVYTK 231
SYPG++T+ M C G G +SC+GDSGGP+VC G LQG+VSWGD C KPGVYTK
Sbjct: 182 KSYPGRLTNTMVCAGAEGRGAESCEGDSGGPLVCGGILQGIVSWGDVPCDNTTKPGVYTK 241
Query: 232 VYNYVKWIKNTIAAN 246
V +Y++WI+ T+ N
Sbjct: 242 VCHYLEWIRETMKRN 256
>gi|117306176 kallikrein-related peptidase 5 preproprotein [Homo
sapiens]
Length = 293
Score = 219 bits (557), Expect = 2e-57
Identities = 108/233 (46%), Positives = 148/233 (63%), Gaps = 5/233 (2%)
Query: 19 DDDDKIVGGYNCEENSVPYQVSL--NSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEH 76
D +I+ G +C+ ++ P+Q +L +CG L++ QW+++A HC K +VRLG +
Sbjct: 62 DSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRVRLGHY 121
Query: 77 NIE-VLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPAT 135
++ V E +Q K I HP Y +ND+MLIKL+ R V I++ + P+
Sbjct: 122 SLSPVYESGQQMFQGVKSIPHPGYSHPGHSNDLMLIKLNRRIRPTKDVRPINVSSHCPSA 181
Query: 136 GTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDS 195
GTKCL+SGWG T S +P LQCL+ VLSQ +CE +YP +I MFC G + G+DS
Sbjct: 182 GTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGD-KAGRDS 240
Query: 196 CQGDSGGPVVCNGQLQGVVSWGD-GCAQKNKPGVYTKVYNYVKWIKNTIAANS 247
CQGDSGGPVVCNG LQG+VSWGD CA+ N+PGVYT + + KWI+ TI ANS
Sbjct: 241 CQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQETIQANS 293
>gi|117306172 kallikrein-related peptidase 5 preproprotein [Homo
sapiens]
Length = 293
Score = 219 bits (557), Expect = 2e-57
Identities = 108/233 (46%), Positives = 148/233 (63%), Gaps = 5/233 (2%)
Query: 19 DDDDKIVGGYNCEENSVPYQVSL--NSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEH 76
D +I+ G +C+ ++ P+Q +L +CG L++ QW+++A HC K +VRLG +
Sbjct: 62 DSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRVRLGHY 121
Query: 77 NIE-VLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPAT 135
++ V E +Q K I HP Y +ND+MLIKL+ R V I++ + P+
Sbjct: 122 SLSPVYESGQQMFQGVKSIPHPGYSHPGHSNDLMLIKLNRRIRPTKDVRPINVSSHCPSA 181
Query: 136 GTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDS 195
GTKCL+SGWG T S +P LQCL+ VLSQ +CE +YP +I MFC G + G+DS
Sbjct: 182 GTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGD-KAGRDS 240
Query: 196 CQGDSGGPVVCNGQLQGVVSWGD-GCAQKNKPGVYTKVYNYVKWIKNTIAANS 247
CQGDSGGPVVCNG LQG+VSWGD CA+ N+PGVYT + + KWI+ TI ANS
Sbjct: 241 CQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQETIQANS 293
>gi|6912644 kallikrein-related peptidase 5 preproprotein [Homo
sapiens]
Length = 293
Score = 219 bits (557), Expect = 2e-57
Identities = 108/233 (46%), Positives = 148/233 (63%), Gaps = 5/233 (2%)
Query: 19 DDDDKIVGGYNCEENSVPYQVSL--NSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEH 76
D +I+ G +C+ ++ P+Q +L +CG L++ QW+++A HC K +VRLG +
Sbjct: 62 DSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRVRLGHY 121
Query: 77 NIE-VLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPAT 135
++ V E +Q K I HP Y +ND+MLIKL+ R V I++ + P+
Sbjct: 122 SLSPVYESGQQMFQGVKSIPHPGYSHPGHSNDLMLIKLNRRIRPTKDVRPINVSSHCPSA 181
Query: 136 GTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDS 195
GTKCL+SGWG T S +P LQCL+ VLSQ +CE +YP +I MFC G + G+DS
Sbjct: 182 GTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGD-KAGRDS 240
Query: 196 CQGDSGGPVVCNGQLQGVVSWGD-GCAQKNKPGVYTKVYNYVKWIKNTIAANS 247
CQGDSGGPVVCNG LQG+VSWGD CA+ N+PGVYT + + KWI+ TI ANS
Sbjct: 241 CQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQETIQANS 293
>gi|91823048 kallikrein 14 preproprotein [Homo sapiens]
Length = 267
Score = 217 bits (553), Expect = 7e-57
Identities = 104/244 (42%), Positives = 150/244 (61%), Gaps = 4/244 (1%)
Query: 4 LLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYH---FCGGSLINEQWVVS 60
L L +A A+ +D++KI+GG+ C +S P+Q +L +G CGG+L++ QWV++
Sbjct: 21 LTALQVLAIAMTQSQEDENKIIGGHTCTRSSQPWQAALLAGPRRRFLCGGALLSGQWVIT 80
Query: 61 AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN 120
A HC + +QV LG+HN+ E +Q + + + HP Y+ +T +ND+ML++L A I
Sbjct: 81 AAHCGRPILQVALGKHNLRRWEATQQVLRVVRQVTHPNYNSRTHDNDLMLLQLQQPARIG 140
Query: 121 ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT 180
V I + A + GT C +SGWG +S A YP LQC++ + C+ +YP IT
Sbjct: 141 RAVRPIEVTQACASPGTSCRVSGWGTISSPIARYPASLQCVNINISPDEVCQKAYPRTIT 200
Query: 181 SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWG-DGCAQKNKPGVYTKVYNYVKWI 239
M C G +GGKDSCQGDSGGP+VC GQLQG+VSWG + CA PGVYT + Y WI
Sbjct: 201 PGMVCAGVPQGGKDSCQGDSGGPLVCRGQLQGLVSWGMERCALPGYPGVYTNLCKYRSWI 260
Query: 240 KNTI 243
+ T+
Sbjct: 261 EETM 264
>gi|61744424 kallikrein-related peptidase 6 isoform A preproprotein
[Homo sapiens]
Length = 244
Score = 213 bits (541), Expect = 2e-55
Identities = 106/244 (43%), Positives = 154/244 (63%), Gaps = 7/244 (2%)
Query: 4 LLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSL-NSGYHFCGGSLINEQWVVSAG 62
+++L+ +AAA A ++ +K+V G C++ S PYQ +L SG+ CGG LI+ WV++A
Sbjct: 5 MVVLSLIAAAWA---EEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAA 61
Query: 63 HCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINAR 122
HC K +QV LG+HN+ E +++ + + + HP YD + + DIML++L+ A ++
Sbjct: 62 HCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSEL 121
Query: 123 VSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSN 182
+ + L A T C I GWG TA D+PD +QC ++S+ +CE +YPG+IT N
Sbjct: 122 IQPLPLERDCSANTTSCHILGWGKTAD--GDFPDTIQCAYIHLVSREECEHAYPGQITQN 179
Query: 183 MFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGD-GCAQKNKPGVYTKVYNYVKWIKN 241
M C G + GKDSCQGDSGGP+VC L+G+VSWG+ C K KPGVYT V Y WI+
Sbjct: 180 MLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQK 239
Query: 242 TIAA 245
TI A
Sbjct: 240 TIQA 243
>gi|4506155 kallikrein-related peptidase 6 isoform A preproprotein
[Homo sapiens]
Length = 244
Score = 213 bits (541), Expect = 2e-55
Identities = 106/244 (43%), Positives = 154/244 (63%), Gaps = 7/244 (2%)
Query: 4 LLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSL-NSGYHFCGGSLINEQWVVSAG 62
+++L+ +AAA A ++ +K+V G C++ S PYQ +L SG+ CGG LI+ WV++A
Sbjct: 5 MVVLSLIAAAWA---EEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAA 61
Query: 63 HCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINAR 122
HC K +QV LG+HN+ E +++ + + + HP YD + + DIML++L+ A ++
Sbjct: 62 HCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSEL 121
Query: 123 VSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSN 182
+ + L A T C I GWG TA D+PD +QC ++S+ +CE +YPG+IT N
Sbjct: 122 IQPLPLERDCSANTTSCHILGWGKTAD--GDFPDTIQCAYIHLVSREECEHAYPGQITQN 179
Query: 183 MFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGD-GCAQKNKPGVYTKVYNYVKWIKN 241
M C G + GKDSCQGDSGGP+VC L+G+VSWG+ C K KPGVYT V Y WI+
Sbjct: 180 MLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQK 239
Query: 242 TIAA 245
TI A
Sbjct: 240 TIQA 243
>gi|4504875 kallikrein 1 preproprotein [Homo sapiens]
Length = 262
Score = 211 bits (536), Expect = 6e-55
Identities = 109/260 (41%), Positives = 152/260 (58%), Gaps = 22/260 (8%)
Query: 5 LILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHF----CGGSLINEQWVVS 60
L L+ A P +IVGG+ CE++S P+Q +L YHF CGG L++ QWV++
Sbjct: 8 LALSLGGTGAAPPIQS--RIVGGWECEQHSQPWQAAL---YHFSTFQCGGILVHRQWVLT 62
Query: 61 AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNN-----------DIM 109
A HC Q+ LG HN+ E QF++ ++ HP ++ L N D+M
Sbjct: 63 AAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLM 122
Query: 110 LIKLSSRA-VINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQ 168
L++L+ A I V + LPT P G+ CL SGWG+ +PD+LQC+D +L
Sbjct: 123 LLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPN 182
Query: 169 AKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWG-DGCAQKNKPG 227
+C+ ++ K+T M CVG LEGGKD+C GDSGGP++C+G LQGV SWG C NKP
Sbjct: 183 DECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPS 242
Query: 228 VYTKVYNYVKWIKNTIAANS 247
V +V +YVKWI++TIA NS
Sbjct: 243 VAVRVLSYVKWIEDTIAENS 262
>gi|21618357 kallikrein 11 isoform 2 precursor [Homo sapiens]
Length = 282
Score = 211 bits (536), Expect = 6e-55
Identities = 109/253 (43%), Positives = 149/253 (58%), Gaps = 7/253 (2%)
Query: 1 MNPLLILTFVAAALAAPF-DDDDKIVGGYNCEENSVPYQVSLNSGYHF-CGGSLINEQWV 58
+ + IL + ALA + +I+ G+ C+ +S P+Q +L CG +LI +W+
Sbjct: 30 LQAMRILQLILLALATGLVGGETRIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWL 89
Query: 59 VSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLN----NDIMLIKLS 114
++A HC K R V LG+HN++ EG EQ A + HP ++ N NDIML+K++
Sbjct: 90 LTAAHCLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMA 149
Query: 115 SRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEAS 174
S I V ++L + GT CLISGWG+T+S P L+C + ++ KCE +
Sbjct: 150 SPVSITWAVRPLTLSSRCVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENA 209
Query: 175 YPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWG-DGCAQKNKPGVYTKVY 233
YPG IT M C EGGKDSCQGDSGGP+VCN LQG++SWG D CA KPGVYTKV
Sbjct: 210 YPGNITDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVYTKVC 269
Query: 234 NYVKWIKNTIAAN 246
YV WI+ T+ N
Sbjct: 270 KYVDWIQETMKNN 282
>gi|209862865 kallikrein 11 isoform 1 preproprotein [Homo sapiens]
Length = 250
Score = 210 bits (535), Expect = 8e-55
Identities = 109/248 (43%), Positives = 147/248 (59%), Gaps = 7/248 (2%)
Query: 6 ILTFVAAALAAPF-DDDDKIVGGYNCEENSVPYQVSLNSGYHF-CGGSLINEQWVVSAGH 63
IL + ALA + +I+ G+ C+ +S P+Q +L CG +LI +W+++A H
Sbjct: 3 ILQLILLALATGLVGGETRIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLLTAAH 62
Query: 64 CYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLN----NDIMLIKLSSRAVI 119
C K R V LG+HN++ EG EQ A + HP ++ N NDIML+K++S I
Sbjct: 63 CLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASPVSI 122
Query: 120 NARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKI 179
V ++L + GT CLISGWG+T+S P L+C + ++ KCE +YPG I
Sbjct: 123 TWAVRPLTLSSRCVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENAYPGNI 182
Query: 180 TSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWG-DGCAQKNKPGVYTKVYNYVKW 238
T M C EGGKDSCQGDSGGP+VCN LQG++SWG D CA KPGVYTKV YV W
Sbjct: 183 TDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVYTKVCKYVDW 242
Query: 239 IKNTIAAN 246
I+ T+ N
Sbjct: 243 IQETMKNN 250
>gi|5803199 kallikrein 11 isoform 1 preproprotein [Homo sapiens]
Length = 250
Score = 210 bits (535), Expect = 8e-55
Identities = 109/248 (43%), Positives = 147/248 (59%), Gaps = 7/248 (2%)
Query: 6 ILTFVAAALAAPF-DDDDKIVGGYNCEENSVPYQVSLNSGYHF-CGGSLINEQWVVSAGH 63
IL + ALA + +I+ G+ C+ +S P+Q +L CG +LI +W+++A H
Sbjct: 3 ILQLILLALATGLVGGETRIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLLTAAH 62
Query: 64 CYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLN----NDIMLIKLSSRAVI 119
C K R V LG+HN++ EG EQ A + HP ++ N NDIML+K++S I
Sbjct: 63 CLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASPVSI 122
Query: 120 NARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKI 179
V ++L + GT CLISGWG+T+S P L+C + ++ KCE +YPG I
Sbjct: 123 TWAVRPLTLSSRCVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENAYPGNI 182
Query: 180 TSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWG-DGCAQKNKPGVYTKVYNYVKW 238
T M C EGGKDSCQGDSGGP+VCN LQG++SWG D CA KPGVYTKV YV W
Sbjct: 183 TDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVYTKVCKYVDW 242
Query: 239 IKNTIAAN 246
I+ T+ N
Sbjct: 243 IQETMKNN 250
>gi|21464127 kallikrein 8 isoform 2 [Homo sapiens]
Length = 305
Score = 210 bits (535), Expect = 8e-55
Identities = 99/230 (43%), Positives = 144/230 (62%), Gaps = 6/230 (2%)
Query: 21 DDKIVGGYNCEENSVPYQVSLNSGYHF-CGGSLINEQWVVSAGHCYKSRIQVRLGEHNIE 79
+DK++GG+ C+ +S P+Q +L G CGG L+ WV++A HC K + VRLG+H+++
Sbjct: 75 EDKVLGGHECQPHSQPWQAALFQGQQLLCGGVLVGGNWVLTAAHCKKPKYTVRLGDHSLQ 134
Query: 80 VLEGNEQFINAAKIIRHPQYDRKTL---NNDIMLIKLSSRAVINARVSTISLPTAPPATG 136
+G EQ I + I HP Y+ + N+D+ML++L +A + ++V ISL G
Sbjct: 135 NKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISLADHCTQPG 194
Query: 137 TKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSC 196
KC +SGWG S ++PD L C + + Q KCE +YPG+IT M C G +G D+C
Sbjct: 195 QKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDAYPGQITDGMVCAGSSKGA-DTC 253
Query: 197 QGDSGGPVVCNGQLQGVVSWG-DGCAQKNKPGVYTKVYNYVKWIKNTIAA 245
QGDSGGP+VC+G LQG+ SWG D C + +KPGVYT + Y+ WIK I +
Sbjct: 254 QGDSGGPLVCDGALQGITSWGSDPCGRSDKPGVYTNICRYLDWIKKIIGS 303
>gi|6005844 kallikrein 8 isoform 1 preproprotein [Homo sapiens]
Length = 260
Score = 210 bits (535), Expect = 8e-55
Identities = 99/230 (43%), Positives = 144/230 (62%), Gaps = 6/230 (2%)
Query: 21 DDKIVGGYNCEENSVPYQVSLNSGYHF-CGGSLINEQWVVSAGHCYKSRIQVRLGEHNIE 79
+DK++GG+ C+ +S P+Q +L G CGG L+ WV++A HC K + VRLG+H+++
Sbjct: 30 EDKVLGGHECQPHSQPWQAALFQGQQLLCGGVLVGGNWVLTAAHCKKPKYTVRLGDHSLQ 89
Query: 80 VLEGNEQFINAAKIIRHPQYDRKTL---NNDIMLIKLSSRAVINARVSTISLPTAPPATG 136
+G EQ I + I HP Y+ + N+D+ML++L +A + ++V ISL G
Sbjct: 90 NKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISLADHCTQPG 149
Query: 137 TKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSC 196
KC +SGWG S ++PD L C + + Q KCE +YPG+IT M C G +G D+C
Sbjct: 150 QKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDAYPGQITDGMVCAGSSKGA-DTC 208
Query: 197 QGDSGGPVVCNGQLQGVVSWG-DGCAQKNKPGVYTKVYNYVKWIKNTIAA 245
QGDSGGP+VC+G LQG+ SWG D C + +KPGVYT + Y+ WIK I +
Sbjct: 209 QGDSGGPLVCDGALQGITSWGSDPCGRSDKPGVYTNICRYLDWIKKIIGS 258
>gi|5031829 kallikrein 2, prostatic isoform 1 [Homo sapiens]
Length = 261
Score = 208 bits (529), Expect = 4e-54
Identities = 108/237 (45%), Positives = 141/237 (59%), Gaps = 13/237 (5%)
Query: 23 KIVGGYNCEENSVPYQVSLNS-GYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVL 81
+IVGG+ CE++S P+QV++ S G+ CGG L++ QWV++A HC K QV LG HN+
Sbjct: 24 RIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKNSQVWLGRHNLFEP 83
Query: 82 EGNEQFINAAKIIRHPQYDRKTL-----------NNDIMLIKLSSRAVINARVSTISLPT 130
E Q + + HP Y+ L ++D+ML++LS A I V + LPT
Sbjct: 84 EDTGQRVPVSHSFPHPLYNMSLLKHQSLRPDEDSSHDLMLLRLSEPAKITDVVKVLGLPT 143
Query: 131 APPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLE 190
PA GT C SGWG+ P LQC+ +LS C +Y K+T M C G
Sbjct: 144 QEPALGTTCYASGWGSIEPEEFLRPRSLQCVSLHLLSNDMCARAYSEKVTEFMLCAGLWT 203
Query: 191 GGKDSCQGDSGGPVVCNGQLQGVVSWG-DGCAQKNKPGVYTKVYNYVKWIKNTIAAN 246
GGKD+C GDSGGP+VCNG LQG+ SWG + CA KP VYTKV +Y KWIK+TIAAN
Sbjct: 204 GGKDTCGGDSGGPLVCNGVLQGITSWGPEPCALPEKPAVYTKVVHYRKWIKDTIAAN 260
>gi|11496281 kallikrein 13 precursor [Homo sapiens]
Length = 277
Score = 204 bits (518), Expect = 7e-53
Identities = 103/225 (45%), Positives = 136/225 (60%), Gaps = 7/225 (3%)
Query: 26 GGYNCEENSVPYQVSLN-SGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGN 84
GGY C +S P+Q +L G CGG L++ +WV++A HC K ++V LG+H + +E
Sbjct: 38 GGYTCFPHSQPWQAALLVQGRLLCGGVLVHPKWVLTAAHCLKEGLKVYLGKHALGRVEAG 97
Query: 85 EQFINAAKIIRHPQYDRKTLN----NDIMLIKLSSRAVINARVSTISLPTAPPAT-GTKC 139
EQ I HP+Y R + +DIML++L S + + T+ L T GT C
Sbjct: 98 EQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQLTGYIQTLPLSHNNRLTPGTTC 157
Query: 140 LISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGD 199
+SGWG T S +YP LQC + + S +C YPGKIT NM C G EGGKDSC+GD
Sbjct: 158 RVSGWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYPGKITDNMLCAGTKEGGKDSCEGD 217
Query: 200 SGGPVVCNGQLQGVVSWGD-GCAQKNKPGVYTKVYNYVKWIKNTI 243
SGGP+VCN L G+VSWGD C Q ++PGVYT+V YV WI+ TI
Sbjct: 218 SGGPLVCNRTLYGIVSWGDFPCGQPDRPGVYTRVSRYVLWIRETI 262
>gi|4502173 prostate specific antigen isoform 1 preproprotein [Homo
sapiens]
Length = 261
Score = 201 bits (512), Expect = 4e-52
Identities = 106/257 (41%), Positives = 145/257 (56%), Gaps = 13/257 (5%)
Query: 3 PLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNS-GYHFCGGSLINEQWVVSA 61
P++ LT + A +IVGG+ CE++S P+QV + S G CGG L++ QWV++A
Sbjct: 4 PVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTA 63
Query: 62 GHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNN-----------DIML 110
HC +++ + LG H++ E Q + HP YD L N D+ML
Sbjct: 64 AHCIRNKSVILLGRHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHDLML 123
Query: 111 IKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAK 170
++LS A + V + LPT PA GT C SGWG+ P +LQC+D V+S
Sbjct: 124 LRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVISNDV 183
Query: 171 CEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWG-DGCAQKNKPGVY 229
C +P K+T M C G GGK +C GDSGGP+VCNG LQG+ SWG + CA +P +Y
Sbjct: 184 CAQVHPQKVTKFMLCAGRWTGGKSTCSGDSGGPLVCNGVLQGITSWGSEPCALPERPSLY 243
Query: 230 TKVYNYVKWIKNTIAAN 246
TKV +Y KWIK+TI AN
Sbjct: 244 TKVVHYRKWIKDTIVAN 260
>gi|21327705 stratum corneum chymotryptic enzyme preproprotein [Homo
sapiens]
Length = 253
Score = 199 bits (505), Expect = 2e-51
Identities = 99/241 (41%), Positives = 141/241 (58%), Gaps = 4/241 (1%)
Query: 5 LILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHF-CGGSLINEQWVVSAGH 63
++L +A A DKI+ G C S P+QV+L SG CGG L+NE+WV++A H
Sbjct: 11 ILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAH 70
Query: 64 CYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARV 123
C + V LG + + Q I A+K RHP Y +T ND+ML+KL+S+A +++ V
Sbjct: 71 CKMNEYTVHLGSDTLG--DRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMV 128
Query: 124 STISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNM 183
+ LP+ GT C +SGWG T S +P +L C+D ++S C Y + ++M
Sbjct: 129 KKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSM 188
Query: 184 FCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGD-GCAQKNKPGVYTKVYNYVKWIKNT 242
C G + K++C GDSGGP+VC G LQG+VSWG C Q N PGVYT+V + KWI +T
Sbjct: 189 LCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDT 248
Query: 243 I 243
+
Sbjct: 249 M 249
>gi|4826950 stratum corneum chymotryptic enzyme preproprotein [Homo
sapiens]
Length = 253
Score = 199 bits (505), Expect = 2e-51
Identities = 99/241 (41%), Positives = 141/241 (58%), Gaps = 4/241 (1%)
Query: 5 LILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHF-CGGSLINEQWVVSAGH 63
++L +A A DKI+ G C S P+QV+L SG CGG L+NE+WV++A H
Sbjct: 11 ILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAH 70
Query: 64 CYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARV 123
C + V LG + + Q I A+K RHP Y +T ND+ML+KL+S+A +++ V
Sbjct: 71 CKMNEYTVHLGSDTLG--DRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMV 128
Query: 124 STISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNM 183
+ LP+ GT C +SGWG T S +P +L C+D ++S C Y + ++M
Sbjct: 129 KKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSM 188
Query: 184 FCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGD-GCAQKNKPGVYTKVYNYVKWIKNT 242
C G + K++C GDSGGP+VC G LQG+VSWG C Q N PGVYT+V + KWI +T
Sbjct: 189 LCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDT 248
Query: 243 I 243
+
Sbjct: 249 M 249
>gi|22208987 kallikrein 12 isoform 2 [Homo sapiens]
Length = 248
Score = 191 bits (485), Expect = 5e-49
Identities = 100/229 (43%), Positives = 135/229 (58%), Gaps = 6/229 (2%)
Query: 23 KIVGGYNCEENSVPYQVSLNSGYHF-CGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVL 81
KI G C NS P+QV L G CGG LI+ +WV++A HC SR VRLGEH++ L
Sbjct: 21 KIFNGTECGRNSQPWQVGLFEGTSLRCGGVLIDHRWVLTAAHCSGSRYWVRLGEHSLSQL 80
Query: 82 EGNEQFINAAKIIRHPQYDRKTLNN--DIMLIKLSSRAVINARVSTISLPTAPPATGTKC 139
+ EQ ++ + HP Y + ++ D+ L++L + + V + LP GT+C
Sbjct: 81 DWTEQIRHSGFSVTHPGYLGASTSHEHDLRLLRLRLPVRVTSSVQPLPLPNDCATAGTEC 140
Query: 140 LISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGD 199
+SGWG T +PD LQCL+ ++S A C YPG+ITSNM C G + G+D+CQGD
Sbjct: 141 HVSGWGITNHPRNPFPDLLQCLNLSIVSHATCHGVYPGRITSNMVCAGGVP-GQDACQGD 199
Query: 200 SGGPVVCNGQLQGVVSWGD--GCAQKNKPGVYTKVYNYVKWIKNTIAAN 246
SGGP+VC G LQG+VSWG C Q PGVYT + YV WI+ + N
Sbjct: 200 SGGPLVCGGVLQGLVSWGSVGPCGQDGIPGVYTYICKYVDWIRMIMRNN 248
>gi|29366812 kallikrein-related peptidase 9 [Homo sapiens]
Length = 250
Score = 188 bits (478), Expect = 3e-48
Identities = 95/229 (41%), Positives = 137/229 (59%), Gaps = 12/229 (5%)
Query: 21 DDKIVGGYNCEENSVPYQVSLNSGYH----FCGGSLINEQWVVSAGHCYKSRIQVRLGEH 76
D + +G C NS P+Q L +H FCG +LI+++W+++A HC K + VRLGEH
Sbjct: 20 DTRAIGAEECRPNSQPWQAGL---FHLTRLFCGATLISDRWLLTAAHCRKPYLWVRLGEH 76
Query: 77 NIEVLEGNEQFINAAKIIRHPQYDRKTL----NNDIMLIKLSSRAVINARVSTISLPTAP 132
++ EG EQ HP +++ N+DIMLI+L +A ++ V ++L
Sbjct: 77 HLWKWEGPEQLFRVTDFFPHPGFNKDLSANDHNDDIMLIRLPRQARLSPAVQPLNLSQTC 136
Query: 133 PATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGG 192
+ G +CLISGWG +S A +P LQC + +L C +YPG I+ +M C G EGG
Sbjct: 137 VSPGMQCLISGWGAVSSPKALFPVTLQCANISILENKLCHWAYPGHISDSMLCAGLWEGG 196
Query: 193 KDSCQGDSGGPVVCNGQLQGVVSWG-DGCAQKNKPGVYTKVYNYVKWIK 240
+ SCQGDSGGP+VCNG L GVVS G + C++ +P VYT V +Y+ WI+
Sbjct: 197 RGSCQGDSGGPLVCNGTLAGVVSGGAEPCSRPRRPAVYTSVCHYLDWIQ 245
>gi|9665236 kallikrein 12 isoform 1 [Homo sapiens]
Length = 254
Score = 182 bits (463), Expect = 2e-46
Identities = 96/217 (44%), Positives = 129/217 (59%), Gaps = 6/217 (2%)
Query: 23 KIVGGYNCEENSVPYQVSLNSGYHF-CGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVL 81
KI G C NS P+QV L G CGG LI+ +WV++A HC SR VRLGEH++ L
Sbjct: 21 KIFNGTECGRNSQPWQVGLFEGTSLRCGGVLIDHRWVLTAAHCSGSRYWVRLGEHSLSQL 80
Query: 82 EGNEQFINAAKIIRHPQYDRKTLNN--DIMLIKLSSRAVINARVSTISLPTAPPATGTKC 139
+ EQ ++ + HP Y + ++ D+ L++L + + V + LP GT+C
Sbjct: 81 DWTEQIRHSGFSVTHPGYLGASTSHEHDLRLLRLRLPVRVTSSVQPLPLPNDCATAGTEC 140
Query: 140 LISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGD 199
+SGWG T +PD LQCL+ ++S A C YPG+ITSNM C G + G+D+CQGD
Sbjct: 141 HVSGWGITNHPRNPFPDLLQCLNLSIVSHATCHGVYPGRITSNMVCAGGVP-GQDACQGD 199
Query: 200 SGGPVVCNGQLQGVVSWGD--GCAQKNKPGVYTKVYN 234
SGGP+VC G LQG+VSWG C Q PGVYT + N
Sbjct: 200 SGGPLVCGGVLQGLVSWGSVGPCGQDGIPGVYTYICN 236
>gi|89142741 kallikrein-related peptidase 4 preproprotein [Homo
sapiens]
Length = 254
Score = 181 bits (459), Expect = 5e-46
Identities = 91/227 (40%), Positives = 134/227 (59%), Gaps = 5/227 (2%)
Query: 23 KIVGGYNCEENSVPYQVSL-NSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEV- 80
+I+ G +C +S P+Q +L FC G L++ QWV+SA HC+++ + LG H++E
Sbjct: 30 QIINGEDCSPHSQPWQAALVMENELFCSGVLVHPQWVLSAAHCFQNSYTIGLGLHSLEAD 89
Query: 81 LEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCL 140
E Q + A+ +RHP+Y+R L ND+MLIKL + + +IS+ + P G CL
Sbjct: 90 QEPGSQMVEASLSVRHPEYNRPLLANDLMLIKLDESVSESDTIRSISIASQCPTAGNSCL 149
Query: 141 ISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDS 200
+SGWG A+ P LQC++ V+S+ C Y +MFC G KDSC GDS
Sbjct: 150 VSGWGLLANGRM--PTVLQCVNVSVVSEEVCSKLYDPLYHPSMFCAGGGHDQKDSCNGDS 207
Query: 201 GGPVVCNGQLQGVVSWGDG-CAQKNKPGVYTKVYNYVKWIKNTIAAN 246
GGP++CNG LQG+VS+G C Q PGVYT + + +WI+ T+ A+
Sbjct: 208 GGPLICNGYLQGLVSFGKAPCGQVGVPGVYTNLCKFTEWIEKTVQAS 254
>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
Length = 1059
Score = 178 bits (452), Expect = 3e-45
Identities = 89/229 (38%), Positives = 128/229 (55%), Gaps = 12/229 (5%)
Query: 23 KIVGGYNCEENSVPYQVSLNSGY-HFCGGSLINEQWVVSAGHCYK----SRIQVRLGEHN 77
++VGG+ VP+QVSL G HFCG +++ ++W++SA HC+ +++ LG +
Sbjct: 503 RVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTKVEQVRAHLGTAS 562
Query: 78 IEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPA--T 135
+ L G+ I +++ HP Y+ L+ D+ +++L+S N + + LP A
Sbjct: 563 LLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYIQPVCLPLAIQKFPV 622
Query: 136 GTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDS 195
G KC+ISGWGNT A P+ LQ ++ Q C Y +T M C GFLEG DS
Sbjct: 623 GRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYNFSLTDRMICAGFLEGKVDS 682
Query: 196 CQGDSGGPVVCNG-----QLQGVVSWGDGCAQKNKPGVYTKVYNYVKWI 239
CQGDSGGP+ C L G+VSWG GCAQ KPGVYT++ WI
Sbjct: 683 CQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWI 731
Score = 156 bits (395), Expect = 1e-38
Identities = 85/232 (36%), Positives = 121/232 (52%), Gaps = 17/232 (7%)
Query: 23 KIVGGYNCEENSVPYQVSLNSGY-HFCGGSLINEQWVVSAGHCYK-----SRIQVRLGEH 76
+IVGG P+Q SL HFCG ++IN +W+VSA HC+ ++ +G
Sbjct: 202 RIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDPTKWVAYVGAT 261
Query: 77 NIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTA----P 132
+ E + +I++HP Y+ T + D+ +++L+S + + LP A P
Sbjct: 262 YLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAATHIFP 321
Query: 133 PATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGG 192
P+ KCLISGWG P+ LQ +L QA C + Y +T M C G+L+G
Sbjct: 322 PSK--KCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASLYGHSLTDRMVCAGYLDGK 379
Query: 193 KDSCQGDSGGPVVCNGQ-----LQGVVSWGDGCAQKNKPGVYTKVYNYVKWI 239
DSCQGDSGGP+VC L G+VSWG GCA+ +PGVY +V WI
Sbjct: 380 VDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWI 431
Score = 144 bits (364), Expect = 5e-35
Identities = 89/231 (38%), Positives = 123/231 (53%), Gaps = 17/231 (7%)
Query: 23 KIVGGYNCEENSVPYQVSL--NSGYHFCGGSLINEQWVVSAGHCYK-----SRIQVRLGE 75
+IVGG P+QVSL H CG L+ E+W++SA HC+ + LG
Sbjct: 826 RIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGT 885
Query: 76 HNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPT-AP-P 133
+ EG Q A+I +HP Y+ TL+ D+ L++L+ + V I LP AP P
Sbjct: 886 PFLSGAEG--QLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAPRP 943
Query: 134 ATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGK 193
GT+C+I+GWG+ G+ +LQ +LS+ C YP +I+S M C GF +GG
Sbjct: 944 PDGTRCVITGWGSVREGGS-MARQLQKAAVRLLSEQTCRRFYPVQISSRMLCAGFPQGGV 1002
Query: 194 DSCQGDSGGPVVCNGQ-----LQGVVSWGDGCAQKNKPGVYTKVYNYVKWI 239
DSC GD+GGP+ C L GV SWG GC + + PGVYT+V WI
Sbjct: 1003 DSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWI 1053
>gi|117422433 kallikrein-related peptidase 10 preproprotein [Homo
sapiens]
Length = 276
Score = 177 bits (450), Expect = 6e-45
Identities = 96/257 (37%), Positives = 142/257 (55%), Gaps = 15/257 (5%)
Query: 3 PLLILTFVAAALAAPFDDDDKI---VGGYNCEENSVPYQVSLNSGYHF-CGGSLINEQWV 58
PLL+ AA A +D ++ G C S P+QVSL +G F C G L+++ WV
Sbjct: 22 PLLMAQLWAAEAALLPQNDTRLDPEAYGSPCARGSQPWQVSLFNGLSFHCAGVLVDQSWV 81
Query: 59 VSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYD--------RKTLNNDIML 110
++A HC + R+G+ ++ +L+G EQ + + HP+Y R+T +D+ML
Sbjct: 82 LTAAHCGNKPLWARVGDDHLLLLQG-EQLRRTTRSVVHPKYHQGSGPILPRRTDEHDLML 140
Query: 111 IKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAK 170
+KL+ V+ RV + LP G +C ++GWG TA+ Y L C +LS +
Sbjct: 141 LKLARPVVLGPRVRALQLPYRCAQPGDQCQVAGWGTTAARRVKYNKGLTCSSITILSPKE 200
Query: 171 CEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWG-DGCAQKNKPGVY 229
CE YPG +T+NM C G L+ G+D CQ DSGGP+VC+ LQG++SWG C P VY
Sbjct: 201 CEVFYPGVVTNNMICAG-LDRGQDPCQSDSGGPLVCDETLQGILSWGVYPCGSAQHPAVY 259
Query: 230 TKVYNYVKWIKNTIAAN 246
T++ Y+ WI I +N
Sbjct: 260 TQICKYMSWINKVIRSN 276
>gi|22208984 kallikrein-related peptidase 10 preproprotein [Homo
sapiens]
Length = 276
Score = 177 bits (450), Expect = 6e-45
Identities = 96/257 (37%), Positives = 142/257 (55%), Gaps = 15/257 (5%)
Query: 3 PLLILTFVAAALAAPFDDDDKI---VGGYNCEENSVPYQVSLNSGYHF-CGGSLINEQWV 58
PLL+ AA A +D ++ G C S P+QVSL +G F C G L+++ WV
Sbjct: 22 PLLMAQLWAAEAALLPQNDTRLDPEAYGSPCARGSQPWQVSLFNGLSFHCAGVLVDQSWV 81
Query: 59 VSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYD--------RKTLNNDIML 110
++A HC + R+G+ ++ +L+G EQ + + HP+Y R+T +D+ML
Sbjct: 82 LTAAHCGNKPLWARVGDDHLLLLQG-EQLRRTTRSVVHPKYHQGSGPILPRRTDEHDLML 140
Query: 111 IKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAK 170
+KL+ V+ RV + LP G +C ++GWG TA+ Y L C +LS +
Sbjct: 141 LKLARPVVLGPRVRALQLPYRCAQPGDQCQVAGWGTTAARRVKYNKGLTCSSITILSPKE 200
Query: 171 CEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWG-DGCAQKNKPGVY 229
CE YPG +T+NM C G L+ G+D CQ DSGGP+VC+ LQG++SWG C P VY
Sbjct: 201 CEVFYPGVVTNNMICAG-LDRGQDPCQSDSGGPLVCDETLQGILSWGVYPCGSAQHPAVY 259
Query: 230 TKVYNYVKWIKNTIAAN 246
T++ Y+ WI I +N
Sbjct: 260 TQICKYMSWINKVIRSN 276
>gi|22208982 kallikrein-related peptidase 10 preproprotein [Homo
sapiens]
Length = 276
Score = 177 bits (450), Expect = 6e-45
Identities = 96/257 (37%), Positives = 142/257 (55%), Gaps = 15/257 (5%)
Query: 3 PLLILTFVAAALAAPFDDDDKI---VGGYNCEENSVPYQVSLNSGYHF-CGGSLINEQWV 58
PLL+ AA A +D ++ G C S P+QVSL +G F C G L+++ WV
Sbjct: 22 PLLMAQLWAAEAALLPQNDTRLDPEAYGSPCARGSQPWQVSLFNGLSFHCAGVLVDQSWV 81
Query: 59 VSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYD--------RKTLNNDIML 110
++A HC + R+G+ ++ +L+G EQ + + HP+Y R+T +D+ML
Sbjct: 82 LTAAHCGNKPLWARVGDDHLLLLQG-EQLRRTTRSVVHPKYHQGSGPILPRRTDEHDLML 140
Query: 111 IKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAK 170
+KL+ V+ RV + LP G +C ++GWG TA+ Y L C +LS +
Sbjct: 141 LKLARPVVLGPRVRALQLPYRCAQPGDQCQVAGWGTTAARRVKYNKGLTCSSITILSPKE 200
Query: 171 CEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWG-DGCAQKNKPGVY 229
CE YPG +T+NM C G L+ G+D CQ DSGGP+VC+ LQG++SWG C P VY
Sbjct: 201 CEVFYPGVVTNNMICAG-LDRGQDPCQSDSGGPLVCDETLQGILSWGVYPCGSAQHPAVY 259
Query: 230 TKVYNYVKWIKNTIAAN 246
T++ Y+ WI I +N
Sbjct: 260 TQICKYMSWINKVIRSN 276
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,023,183
Number of Sequences: 37866
Number of extensions: 442834
Number of successful extensions: 1634
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 165
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 910
Number of HSP's gapped (non-prelim): 204
length of query: 247
length of database: 18,247,518
effective HSP length: 100
effective length of query: 147
effective length of database: 14,460,918
effective search space: 2125754946
effective search space used: 2125754946
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.