Search of human proteins with 4505685

Search of human proteins with 4505685

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4505685 pyruvate dehydrogenase E1 alpha 1 precursor [Homo
sapiens]
         (390 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4505685 pyruvate dehydrogenase E1 alpha 1 precursor [Homo sap...   793   0.0  
gi|4885543 pyruvate dehydrogenase E1 alpha 2 [Homo sapiens]           682   0.0  
gi|11386135 branched chain keto acid dehydrogenase E1, alpha pol...   120   3e-27
gi|38788380 dehydrogenase E1 and transketolase domain containing...    41   0.002
gi|51873036 oxoglutarate (alpha-ketoglutarate) dehydrogenase (li...    37   0.040
gi|205277463 transketolase isoform 1 [Homo sapiens]                    35   0.15 
gi|4507521 transketolase isoform 1 [Homo sapiens]                      35   0.15 
gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens]    32   1.3  
gi|133778974 transketolase-like 2 [Homo sapiens]                       30   3.7  
gi|189217904 RPGRIP1-like isoform b [Homo sapiens]                     29   6.4  
gi|19923233 sterol carrier protein 2 isoform 1 proprotein [Homo ...    29   8.3  
gi|94421473 paternally expressed 10 isoform RF1 [Homo sapiens]         29   8.3  
gi|94421475 paternally expressed 10 isoform RF1/2 [Homo sapiens]       29   8.3  
gi|205277465 transketolase isoform 2 [Homo sapiens]                    29   8.3  

>gi|4505685 pyruvate dehydrogenase E1 alpha 1 precursor [Homo
           sapiens]
          Length = 390

 Score =  793 bits (2049), Expect = 0.0
 Identities = 390/390 (100%), Positives = 390/390 (100%)

Query: 1   MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED 60
           MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
Sbjct: 1   MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED 60

Query: 61  GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA 120
           GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
Sbjct: 61  GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA 120

Query: 121 HGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA 180
           HGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
Sbjct: 121 HGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA 180

Query: 181 CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST 240
           CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
Sbjct: 181 CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST 240

Query: 241 DYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS 300
           DYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
Sbjct: 241 DYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS 300

Query: 301 YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP 360
           YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
Sbjct: 301 YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP 360

Query: 361 LEELGYHIYSSDPPFEVRGANQWIKFKSVS 390
           LEELGYHIYSSDPPFEVRGANQWIKFKSVS
Sbjct: 361 LEELGYHIYSSDPPFEVRGANQWIKFKSVS 390


>gi|4885543 pyruvate dehydrogenase E1 alpha 2 [Homo sapiens]
          Length = 388

 Score =  682 bits (1760), Expect = 0.0
 Identities = 333/388 (85%), Positives = 356/388 (91%), Gaps = 1/388 (0%)

Query: 4   MLAA-VSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTREDGL 62
           MLAA +SRVL   +QK A RVLVASRN +NDATFEIKKCDL+ LEEGPPVTTVLTR +GL
Sbjct: 1   MLAAFISRVLRRVAQKSARRVLVASRNSSNDATFEIKKCDLYLLEEGPPVTTVLTRAEGL 60

Query: 63  KYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHG 122
           KYYRMM TVRRMELKADQLYKQK IRGFCHLCDGQEACCVGLEAGINP+DH+IT+YRAHG
Sbjct: 61  KYYRMMLTVRRMELKADQLYKQKFIRGFCHLCDGQEACCVGLEAGINPSDHVITSYRAHG 120

Query: 123 FTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACK 182
             +TRGLSVR ILAELTGR+GGCAKGKGGSMHMY KNFYGGNGIVGAQ PLGAGIALACK
Sbjct: 121 VCYTRGLSVRSILAELTGRRGGCAKGKGGSMHMYTKNFYGGNGIVGAQGPLGAGIALACK 180

Query: 183 YNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAASTDY 242
           Y G DE+CLTLYGDGAANQGQI EA+NMAALWKLPC+FICENN YGMGTS ERAAAS DY
Sbjct: 181 YKGNDEICLTLYGDGAANQGQIAEAFNMAALWKLPCVFICENNLYGMGTSTERAAASPDY 240

Query: 243 YKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVSYR 302
           YKRG+FIPGL+VDGMD+LCVREAT+FAA YCRSGKGPILMELQTYRYHGHSMSDPGVSYR
Sbjct: 241 YKRGNFIPGLKVDGMDVLCVREATKFAANYCRSGKGPILMELQTYRYHGHSMSDPGVSYR 300

Query: 303 TREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLE 362
           TREEIQEVRSK DPI++L+DRMVNS LA+VEELKEI  EVRKEI+DAAQFAT DPEP LE
Sbjct: 301 TREEIQEVRSKRDPIIILQDRMVNSKLATVEELKEIGAEVRKEIDDAAQFATTDPEPHLE 360

Query: 363 ELGYHIYSSDPPFEVRGANQWIKFKSVS 390
           ELG+HIYSSD  FEVRGAN WIKFKSVS
Sbjct: 361 ELGHHIYSSDSSFEVRGANPWIKFKSVS 388


>gi|11386135 branched chain keto acid dehydrogenase E1, alpha
           polypeptide [Homo sapiens]
          Length = 445

 Score =  120 bits (300), Expect = 3e-27
 Identities = 89/322 (27%), Positives = 140/322 (43%), Gaps = 5/322 (1%)

Query: 56  LTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLI 115
           L +E  LK Y+ M  +  M+    +  +Q  I  F     G+E   VG  A ++ TD + 
Sbjct: 97  LPKEKVLKLYKSMTLLNTMDRILYESQRQGRI-SFYMTNYGEEGTHVGSAAALDNTDLVF 155

Query: 116 TAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAK--NFYGGNGIVGAQVPL 173
             YR  G    R   +   +A+  G      KG+   +H   K  +F   +  +  Q+P 
Sbjct: 156 GQYREAGVLMYRDYPLELFMAQCYGNISDLGKGRQMPVHYGCKERHFVTISSPLATQIPQ 215

Query: 174 GAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSV 233
             G A A K    + V +  +G+GAA++G     +N AA  + P IF C NN Y + T  
Sbjct: 216 AVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPT 275

Query: 234 ERAAASTDYYKRGDF--IPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHG 291
                      RG    I  +RVDG D+  V  AT+ A     +   P L+E  TYR   
Sbjct: 276 SEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGH 335

Query: 292 HSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQ 351
           HS SD   +YR+ +E+     +  PI  L+  +++      E+ K    + R+++ +A +
Sbjct: 336 HSTSDDSSAYRSVDEVNYWDKQDHPISRLRHYLLSQGWWDEEQEKAWRKQSRRKVMEAFE 395

Query: 352 FATADPEPPLEELGYHIYSSDP 373
            A   P+P    L   +Y   P
Sbjct: 396 QAERKPKPNPNLLFSDVYQEMP 417


>gi|38788380 dehydrogenase E1 and transketolase domain containing 1
           [Homo sapiens]
          Length = 919

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 40/170 (23%), Positives = 72/170 (42%), Gaps = 7/170 (4%)

Query: 185 GKDEVCLTLYGDGA-ANQGQIFEAYNMAALWKLPC---IFICENNRYGMGTSVERAAAST 240
           G   +CL ++GD +   QG + E + ++ L        + +  NN+ G  T  ER  +S 
Sbjct: 322 GDRVICLQVHGDASFCGQGIVPETFTLSNLPHFRIGGSVHLIVNNQLGYTTPAERGRSSL 381

Query: 241 DYYKRGDFIPG--LRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPG 298
                G  +    + V+G     V  ATR A  Y R  +  ++++L  YR  GH+  D  
Sbjct: 382 YCSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEP 441

Query: 299 VSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIED 348
             Y      + +R++        + ++   L + EE+ EI      ++ D
Sbjct: 442 F-YTNPIMYKIIRARKSIPDTYAEHLIAGGLMTQEEVSEIKSSYYAKLND 490


>gi|51873036 oxoglutarate (alpha-ketoglutarate) dehydrogenase
           (lipoamide) isoform 1 precursor [Homo sapiens]
          Length = 1023

 Score = 36.6 bits (83), Expect = 0.040
 Identities = 39/172 (22%), Positives = 77/172 (44%), Gaps = 9/172 (5%)

Query: 185 GKDEVCLTLYGDGA-ANQGQIFEAYNMAALWKLPC---IFICENNRYGMGTSVERAAAST 240
           GK  + + L+GD A A QG ++E ++++ L        + +  NN+ G  T   R A S+
Sbjct: 400 GKKVMSILLHGDAAFAGQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTD-PRMARSS 458

Query: 241 DY---YKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDP 297
            Y     R    P   V+  D   V    + AA +  +    ++++L  YR +GH+  D 
Sbjct: 459 PYPTDVARVVNAPIFHVNSDDPEAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDE 518

Query: 298 GVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDA 349
            + +      +++R +   +    + +V+  + +  E +E   +  K  E+A
Sbjct: 519 PM-FTQPLMYKQIRKQKPVLQKYAELLVSQGVVNQPEYEEEISKYDKICEEA 569


>gi|205277463 transketolase isoform 1 [Homo sapiens]
          Length = 623

 Score = 34.7 bits (78), Expect = 0.15
 Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 8/81 (9%)

Query: 173 LGAGIALAC--KYNGK--DEVCLTLY---GDGAANQGQIFEAYNMAALWKLP-CIFICEN 224
           LG G+  AC   Y GK  D+    +Y   GDG  ++G ++EA   A+++KL   + I + 
Sbjct: 125 LGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDI 184

Query: 225 NRYGMGTSVERAAASTDYYKR 245
           NR G             Y KR
Sbjct: 185 NRLGQSDPAPLQHQMDIYQKR 205


>gi|4507521 transketolase isoform 1 [Homo sapiens]
          Length = 623

 Score = 34.7 bits (78), Expect = 0.15
 Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 8/81 (9%)

Query: 173 LGAGIALAC--KYNGK--DEVCLTLY---GDGAANQGQIFEAYNMAALWKLP-CIFICEN 224
           LG G+  AC   Y GK  D+    +Y   GDG  ++G ++EA   A+++KL   + I + 
Sbjct: 125 LGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDI 184

Query: 225 NRYGMGTSVERAAASTDYYKR 245
           NR G             Y KR
Sbjct: 185 NRLGQSDPAPLQHQMDIYQKR 205


>gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens]
          Length = 479

 Score = 31.6 bits (70), Expect = 1.3
 Identities = 17/45 (37%), Positives = 22/45 (48%)

Query: 33  DATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELK 77
           D   E   CDLHRLEE      V   + GL Y   M ++R + L+
Sbjct: 361 DMALEYVACDLHRLEELVLDRCVRITDTGLSYLSTMSSLRSLYLR 405


>gi|133778974 transketolase-like 2 [Homo sapiens]
          Length = 626

 Score = 30.0 bits (66), Expect = 3.7
 Identities = 20/64 (31%), Positives = 35/64 (54%), Gaps = 8/64 (12%)

Query: 173 LGAGIALAC--KYNGK--DEVCLTLY---GDGAANQGQIFEAYNMAALWKLP-CIFICEN 224
           LG G+  AC   Y GK  D+    ++   GDG +++G ++EA+  A+ + L   + + + 
Sbjct: 126 LGQGLGTACGMAYTGKYLDKASYRVFCLMGDGESSEGSVWEAFAFASHYNLDNLVAVFDV 185

Query: 225 NRYG 228
           NR G
Sbjct: 186 NRLG 189


>gi|189217904 RPGRIP1-like isoform b [Homo sapiens]
          Length = 1235

 Score = 29.3 bits (64), Expect = 6.4
 Identities = 16/68 (23%), Positives = 34/68 (50%), Gaps = 1/68 (1%)

Query: 290  HGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKD-RMVNSNLASVEELKEIDVEVRKEIED 348
            H   +S  G     +E  ++++   D + LL + ++   +LAS E+  EI  ++  E+E+
Sbjct: 983  HQSDVSQEGSVDEVKENTEKMQQGKDDVSLLSEGQLAEQSLASSEDETEITEDLEPEVEE 1042

Query: 349  AAQFATAD 356
                + +D
Sbjct: 1043 DMSASDSD 1050


>gi|19923233 sterol carrier protein 2 isoform 1 proprotein [Homo
           sapiens]
          Length = 547

 Score = 28.9 bits (63), Expect = 8.3
 Identities = 28/104 (26%), Positives = 39/104 (37%), Gaps = 21/104 (20%)

Query: 105 EAGINPTDHLITAYRAHGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGG- 163
           ++G+ P D  I     H    T  L   E L       G C +G+G ++     N YGG 
Sbjct: 291 KSGLTPND--IDVIELHDCFSTNELLTYEAL-------GLCPEGQGATLVDRGDNTYGGK 341

Query: 164 ------NGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQ 201
                  G++    PLGA     C      E+C  L G+    Q
Sbjct: 342 WVINPSGGLISKGHPLGATGLAQCA-----ELCWQLRGEAGKRQ 380


>gi|94421473 paternally expressed 10 isoform RF1 [Homo sapiens]
          Length = 325

 Score = 28.9 bits (63), Expect = 8.3
 Identities = 22/71 (30%), Positives = 35/71 (49%), Gaps = 17/71 (23%)

Query: 305 EEIQEVRSKSDPIMLLKDRMVNSNLAS-VEELKEIDVEVRKEIEDAAQ-----------F 352
           EEI  +R K     ++K    N+NL S V++L E +  +R+++E   +            
Sbjct: 11  EEINNLREK-----VMKQSEENNNLQSQVQKLTEENTTLREQVEPTPEDEDDDIELRGAA 65

Query: 353 ATADPEPPLEE 363
           A A P PP+EE
Sbjct: 66  AAAAPPPPIEE 76


>gi|94421475 paternally expressed 10 isoform RF1/2 [Homo sapiens]
          Length = 708

 Score = 28.9 bits (63), Expect = 8.3
 Identities = 22/71 (30%), Positives = 35/71 (49%), Gaps = 17/71 (23%)

Query: 305 EEIQEVRSKSDPIMLLKDRMVNSNLAS-VEELKEIDVEVRKEIEDAAQ-----------F 352
           EEI  +R K     ++K    N+NL S V++L E +  +R+++E   +            
Sbjct: 11  EEINNLREK-----VMKQSEENNNLQSQVQKLTEENTTLREQVEPTPEDEDDDIELRGAA 65

Query: 353 ATADPEPPLEE 363
           A A P PP+EE
Sbjct: 66  AAAAPPPPIEE 76


>gi|205277465 transketolase isoform 2 [Homo sapiens]
          Length = 540

 Score = 28.9 bits (63), Expect = 8.3
 Identities = 17/54 (31%), Positives = 26/54 (48%), Gaps = 1/54 (1%)

Query: 193 LYGDGAANQGQIFEAYNMAALWKLP-CIFICENNRYGMGTSVERAAASTDYYKR 245
           L GDG  ++G ++EA   A+++KL   + I + NR G             Y KR
Sbjct: 69  LLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKR 122


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,271,888
Number of Sequences: 37866
Number of extensions: 687755
Number of successful extensions: 1589
Number of sequences better than 10.0: 14
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 1583
Number of HSP's gapped (non-prelim): 14
length of query: 390
length of database: 18,247,518
effective HSP length: 104
effective length of query: 286
effective length of database: 14,309,454
effective search space: 4092503844
effective search space used: 4092503844
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.