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Search of human proteins with 4505461
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505461 ectodermal-neural cortex (with BTB-like domain)
[Homo sapiens]
(589 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 1202 0.0
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 929 0.0
gi|40018614 DRE1 protein [Homo sapiens] 283 4e-76
gi|40807500 kelch-like 20 [Homo sapiens] 270 2e-72
gi|40255071 kelch-like 23 [Homo sapiens] 266 4e-71
gi|166235129 kelch-like 3 [Homo sapiens] 261 2e-69
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 256 5e-68
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 256 5e-68
gi|109150407 kelch-like 6 [Homo sapiens] 251 2e-66
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 250 2e-66
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 250 2e-66
gi|38194229 kelch-like 17 [Homo sapiens] 250 3e-66
gi|11056006 kelch-like 12 [Homo sapiens] 248 1e-65
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 248 1e-65
gi|194097389 kelch-like 38 [Homo sapiens] 244 1e-64
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 243 3e-64
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 243 3e-64
gi|55925608 kelch-like 21 [Homo sapiens] 240 3e-63
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 239 7e-63
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 239 7e-63
gi|55925604 kelch-like 18 [Homo sapiens] 234 1e-61
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 231 1e-60
gi|128485503 kelch-like 30 [Homo sapiens] 229 7e-60
gi|14780904 kelch-like 1 protein [Homo sapiens] 224 2e-58
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 216 4e-56
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 214 2e-55
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 214 2e-55
gi|148664209 kelch-like 10 [Homo sapiens] 214 2e-55
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 210 3e-54
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 209 7e-54
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 1202 bits (3110), Expect = 0.0
Identities = 589/589 (100%), Positives = 589/589 (100%)
Query: 1 MSVSVHENRKSRASSGSINIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCH 60
MSVSVHENRKSRASSGSINIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCH
Sbjct: 1 MSVSVHENRKSRASSGSINIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCH 60
Query: 61 RAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESL 120
RAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESL
Sbjct: 61 RAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESL 120
Query: 121 LEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIR 180
LEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIR
Sbjct: 121 LEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIR 180
Query: 181 KNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLAL 240
KNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLAL
Sbjct: 181 KNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLAL 240
Query: 241 LPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLL 300
LPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLL
Sbjct: 241 LPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLL 300
Query: 301 GGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWV 360
GGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWV
Sbjct: 301 GGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWV 360
Query: 361 YDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPT 420
YDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPT
Sbjct: 361 YDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPT 420
Query: 421 INKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQ 480
INKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQ
Sbjct: 421 INKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQ 480
Query: 481 PWRYTAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKL 540
PWRYTAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKL
Sbjct: 481 PWRYTAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKL 540
Query: 541 YVVGGYFGIQRCKTLDCYDPTLDVWNSITTVPYSLIPTAFVSTWKHLPS 589
YVVGGYFGIQRCKTLDCYDPTLDVWNSITTVPYSLIPTAFVSTWKHLPS
Sbjct: 541 YVVGGYFGIQRCKTLDCYDPTLDVWNSITTVPYSLIPTAFVSTWKHLPS 589
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 929 bits (2400), Expect = 0.0
Identities = 440/589 (74%), Positives = 512/589 (86%)
Query: 1 MSVSVHENRKSRASSGSINIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCH 60
MSVSVHE RKSR+S+GS+N+ LFHK+S+ D VL HLN LR+ +FTDV L AG+R FPCH
Sbjct: 1 MSVSVHETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCH 60
Query: 61 RAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESL 120
RAVLAA SRYFEAMFS GL+ES+D VNF +++HPEVLELLLD+AYSSR+ INEENAESL
Sbjct: 61 RAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESL 120
Query: 121 LEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIR 180
LEAGDML+F D+RDA AEFLEKNL P+NCLGM+LLSDAHQC +LYE SWRMCL +F+T+R
Sbjct: 121 LEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVR 180
Query: 181 KNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLAL 240
++EDF L +D ++ L+SS+ELETEDER+V+E+ + W+ +DL+ R +LPELL++VRLAL
Sbjct: 181 QSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLAL 240
Query: 241 LPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLL 300
LP+ L E V+ E L+ ++K I++EA+RCK +ILQNDGVVTS CARPRK GH L +L
Sbjct: 241 LPSDCLQEAVSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAGHTLLIL 300
Query: 301 GGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWV 360
GGQTFMCDK+Y VD KAKEIIPKAD+PSPRKEFSA AIGCKVY+TGGRGSENGVSKDVWV
Sbjct: 301 GGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWV 360
Query: 361 YDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPT 420
YDT+HEEWSKAAPML+ARFGHGSAEL++CLYVVGGHT+ G PASPSVSLKQVE YDP
Sbjct: 361 YDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPG 420
Query: 421 INKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQ 480
NKW MVAPLR+GVSNAAVVSAKLKLF FGGTS+ D + KVQCYD ENRWT+ A CPQ
Sbjct: 421 ANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQ 480
Query: 481 PWRYTAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKL 540
PWRYTAAAVLG+QIFIMGGDTEF+A SAY+F+ ET QWT++GD+TAKRMSCHA+ASGNKL
Sbjct: 481 PWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKL 540
Query: 541 YVVGGYFGIQRCKTLDCYDPTLDVWNSITTVPYSLIPTAFVSTWKHLPS 589
YVVGGYFG QRCKTLDCYDPT D WN ITTVPYSLIPTAFVSTWKHLP+
Sbjct: 541 YVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVSTWKHLPA 589
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 283 bits (723), Expect = 4e-76
Identities = 184/556 (33%), Positives = 283/556 (50%), Gaps = 31/556 (5%)
Query: 26 SSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDS 85
SS+A+++L N R RLFTDV++ + FPCHRAVL+ACS YF AMF +ES++
Sbjct: 46 SSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREM 105
Query: 86 EVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLH 145
V N I E +E L Y Y+ +V I EN + L E + + +RDACA+FLE+ L
Sbjct: 106 LVEI-NGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLD 164
Query: 146 PTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETE 205
P NCLG+ +D H L+ L F+ + ++E+FL+L +D ++ + S+EL
Sbjct: 165 PCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIG 224
Query: 206 DERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEI 265
E +V+E+ + W+ + R L ELL VRL LL Y ++ V +++LI + ++
Sbjct: 225 KEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQL 284
Query: 266 VEEAIRCKLKILQNDGVVTSLCARPRK-TGHA--LFLLGG----QTFMCDKLYLVDQKAK 318
+ EA R IL N+ + S RPR+ TG++ + ++GG F D
Sbjct: 285 LHEARR--YHILGNE--MMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTG 340
Query: 319 EIIPKADIPS-PRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVA 377
E A +P + E++ CA+ + ++GGR + S+DVW+Y++ W + A +
Sbjct: 341 EWKSLAKLPEFTKSEYAVCALRNDILVSGGRIN----SRDVWIYNSQLNIWIRVASLNKG 396
Query: 378 RFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNA 437
R+ H A L +YVVGG+ L VE YD N+WT VAPL+E VS+
Sbjct: 397 RWRHKMAVLLGKVYVVGGYDGQN---------RLSSVECYDSFSNRWTEVAPLKEAVSSP 447
Query: 438 AVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIM 497
AV S KLF GG + KVQ YD N W + A P R A L N I++
Sbjct: 448 AVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVA 507
Query: 498 GGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGG-YFGIQRCKTLD 556
GG T+ + Y ++ W V + +++ +C K+Y++GG + T+
Sbjct: 508 GGLTK----AIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTIL 563
Query: 557 CYDPTLDVWNSITTVP 572
CYDP + + +P
Sbjct: 564 CYDPATSIITGVAAMP 579
Score = 57.0 bits (136), Expect = 5e-08
Identities = 34/125 (27%), Positives = 54/125 (43%), Gaps = 3/125 (2%)
Query: 459 LPKVQCYDQCENRWTVPATCPQPWRYT-AAAVLGNQIFIMGGDTEFSACSAYKFNSETYQ 517
LP +CYD W A P+ + A L N I + GG ++ + +NS+
Sbjct: 329 LPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGG--RINSRDVWIYNSQLNI 386
Query: 518 WTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTVPYSLIP 577
W +V + R K+YVVGGY G R +++CYD + W + + ++
Sbjct: 387 WIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSS 446
Query: 578 TAFVS 582
A S
Sbjct: 447 PAVTS 451
Score = 50.8 bits (120), Expect = 3e-06
Identities = 36/144 (25%), Positives = 55/144 (38%), Gaps = 14/144 (9%)
Query: 341 KVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAAT 400
K+++ GG +N S V YD W A + +A+ + L + +YV GG T A
Sbjct: 455 KLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAI 514
Query: 401 GCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLP 460
C YDP + W V N + K++ GG + +
Sbjct: 515 YC--------------YDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATD 560
Query: 461 KVQCYDQCENRWTVPATCPQPWRY 484
+ CYD + T A P+P Y
Sbjct: 561 TILCYDPATSIITGVAAMPRPVSY 584
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 270 bits (691), Expect = 2e-72
Identities = 177/540 (32%), Positives = 274/540 (50%), Gaps = 26/540 (4%)
Query: 36 LNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHP 95
+NLLR+ R DV+L G + HR +L+ACS YF AMF+G L ES+ +EV I
Sbjct: 58 INLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVI-RDIDE 116
Query: 96 EVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLL 155
+ELL+D+AY+S++ + E N ++LL A +L+ +I++AC EFL++ L P+NCLG+
Sbjct: 117 RAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAF 176
Query: 156 SDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAI 215
+D H C +L ++ + NFQ + ++E+F+ LP + ++ ++SS+EL E V+ + +
Sbjct: 177 ADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVM 236
Query: 216 NWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLK 275
W+ Y +++R LP++LQ VRL LL +L+ V + LI + +++V+EA + L
Sbjct: 237 AWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEA-KNYLL 295
Query: 276 ILQNDGVVTSLCARPRK---TGHALFLLGGQTFMCDKLYLVDQKAKEIIPKADIPSPRKE 332
+ Q ++ RPRK G LF +GG D + V++ + + S K
Sbjct: 296 LPQERPLMQGPRTRPRKPIRCGEVLFAVGGWC-SGDAISSVERYDPQTNEWRMVASMSKR 354
Query: 333 FSACAIGCKV-----YITGGRGSENGVSKDVWVYDTLHEEWSK-AAPMLVARFGHGSAEL 386
C +G V Y GG + ++ V YD +WS AP R G A L
Sbjct: 355 --RCGVGVSVLDDLLYAVGGHDGSSYLN-SVERYDPKTNQWSSDVAPTSTCRTSVGVAVL 411
Query: 387 KHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKL 446
LY VGG + L VE YDP NKWT VA + AV L
Sbjct: 412 GGFLYAVGGQDGVS---------CLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFL 462
Query: 447 FAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG-DTEFSA 505
+A GG S L V+ Y+ ENRW A ++ AV + I+ +GG D
Sbjct: 463 YAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTEL 521
Query: 506 CSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVW 565
SA ++N T QW+ V +T++R +L VGG+ G KT++ +DP + W
Sbjct: 522 SSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTW 581
Score = 72.4 bits (176), Expect = 1e-12
Identities = 46/161 (28%), Positives = 76/161 (47%), Gaps = 3/161 (1%)
Query: 410 SLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCE 469
++ VE YDP N+W MVA + + V L+A GG S L V+ YD
Sbjct: 331 AISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGS-SYLNSVERYDPKT 389
Query: 470 NRWTVPATCPQPWRYTAA-AVLGNQIFIMGGDTEFSACSAY-KFNSETYQWTKVGDVTAK 527
N+W+ R + AVLG ++ +GG S + +++ + +WT+V ++ +
Sbjct: 390 NQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTR 449
Query: 528 RMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSI 568
R+ G LY VGG G T++ Y+P + W++I
Sbjct: 450 RLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTI 490
Score = 52.8 bits (125), Expect = 9e-07
Identities = 36/128 (28%), Positives = 59/128 (46%), Gaps = 3/128 (2%)
Query: 446 LFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG-DTEFS 504
LFA GG S D + V+ YD N W + A+ + +VL + ++ +GG D
Sbjct: 320 LFAVGGWC-SGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSY 378
Query: 505 ACSAYKFNSETYQWTK-VGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLD 563
S +++ +T QW+ V + R S G LY VGG G+ ++ YDP +
Sbjct: 379 LNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKEN 438
Query: 564 VWNSITTV 571
W + ++
Sbjct: 439 KWTRVASM 446
Score = 37.0 bits (84), Expect = 0.051
Identities = 28/103 (27%), Positives = 38/103 (36%), Gaps = 10/103 (9%)
Query: 324 ADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGS 383
A + + RK +Y GGR +S Y+ +WS M R G G
Sbjct: 491 APMGTRRKHLGCAVYQDMIYAVGGRDDTTELSS-AERYNPRTNQWSPVVAMTSRRSGVGL 549
Query: 384 AELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTM 426
A + L VGG T LK +E +DP N W +
Sbjct: 550 AVVNGQLMAVGGFDGTT---------YLKTIEVFDPDANTWRL 583
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 266 bits (680), Expect = 4e-71
Identities = 165/568 (29%), Positives = 293/568 (51%), Gaps = 42/568 (7%)
Query: 20 IYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRT-FPCHRAVLAACSRYFEAMFSGG 78
IYLF S++ L LFTD+ L + F CHRAVLAACS YF+AMF+
Sbjct: 10 IYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTAD 69
Query: 79 LKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAE 138
+KE +++ + IH ++LE L++YAY+S++ I + N +SLLEA D+L+F ++ AC
Sbjct: 70 MKEKFKNKIKL-SGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACER 128
Query: 139 FLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLS 198
FL ++L NC+GM ++ H C +L + S R+ S F+ + + E+FL++ + + +LS
Sbjct: 129 FLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILS 188
Query: 199 SEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAME-ELIT 257
+ L E + E I W ++D++ R L LL + + + P +YL + ++ +
Sbjct: 189 RKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDIDP-VYLKTALGLQRSCLL 247
Query: 258 KQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLLGGQTF-MCDKLYLVDQK 316
+ K + ++ A+ K + T ++++GG + ++++ D
Sbjct: 248 TENKIRSLIYNALNPMHKEISQRSTAT------------MYIIGGYYWHPLSEVHIWDPL 295
Query: 317 AKEIIPKADIPS-PRKEFSACAIGCKVYITGGRGSENGVSKD-VWVYDTLHEEWSKAAPM 374
I A+IP R+ + +G +Y+TGG ++N + D VW+Y++ +EW++ PM
Sbjct: 296 TNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPM 355
Query: 375 LVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGV 434
L AR+ H + L C+Y +GG+ PA ++ E YDP KW +A + +GV
Sbjct: 356 LNARYYHCAVTLGGCVYALGGYRKGA---PA------EEAEFYDPLKEKWIPIANMIKGV 406
Query: 435 SNAAVVSAKLKLFAFGG-----TSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAV 489
NA ++ GG S ++D KVQ Y+ N W++ + P P +
Sbjct: 407 GNATACVLHDVIYVIGGHCGYRGSCTYD---KVQSYNSDINEWSLITSSPHPEYGLCSVP 463
Query: 490 LGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGI 549
N+++++GG T + C ++ E +W ++ + +RM C AV +YV GGY
Sbjct: 464 FENKLYLVGGQTTITEC----YDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYS 519
Query: 550 Q--RCKTLDCYDPTLDVWNSITTVPYSL 575
+ ++++ YDP L+ W + +P ++
Sbjct: 520 KGTYLQSIEKYDPDLNKWEIVGNLPSAM 547
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 261 bits (666), Expect = 2e-69
Identities = 172/543 (31%), Positives = 264/543 (48%), Gaps = 21/543 (3%)
Query: 36 LNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHP 95
+N LR ++L DV++ A + HR VLAACS YF AMF+G + ES+ ++ + +
Sbjct: 40 MNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKD-VDG 98
Query: 96 EVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLL 155
+ L L+DY Y++ + + EEN + LL A +L+ D+R C +FL+ LHPTNCLG+
Sbjct: 99 QTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAF 158
Query: 156 SDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAI 215
+D H CT L + + +F + E+FL L D V L+SS++L E V+E+ I
Sbjct: 159 ADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVI 218
Query: 216 NWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLK 275
+WI+Y+ + R ++ +L++ VRL LLP YL++ V E LI K+ + EA++ L
Sbjct: 219 SWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLL 278
Query: 276 ILQNDGVVTSLCARPR---KTGHALFLLGGQ---TFMCDKLYLVDQKAKEIIPKADIPSP 329
L ++ + +PR + ++GGQ + Y ++ + I A++PS
Sbjct: 279 PLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQI--AELPSR 336
Query: 330 RKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHC 389
R + VY GG V + V VYD + ++W+ A M R G+A L
Sbjct: 337 RCRAGVVFMAGHVYAVGGFNGSLRV-RTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDL 395
Query: 390 LYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAF 449
LY VGG +TG L VE Y N+W VAP+ S+ V + KL+A
Sbjct: 396 LYAVGGFDGSTG---------LASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAV 446
Query: 450 GG-TSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG-DTEFSACS 507
GG S L V+ Y+ N W A VL Q++ GG D S
Sbjct: 447 GGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKS 506
Query: 508 AYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNS 567
++ T W +V D+ R + A LYVVGG G +++ Y+P D W
Sbjct: 507 VEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTL 566
Query: 568 ITT 570
+ T
Sbjct: 567 LPT 569
Score = 47.0 bits (110), Expect = 5e-05
Identities = 21/78 (26%), Positives = 40/78 (51%)
Query: 494 IFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCK 553
+ ++GG + S ++ E +W ++ ++ ++R V +Y VGG+ G R +
Sbjct: 303 MIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVR 362
Query: 554 TLDCYDPTLDVWNSITTV 571
T+D YD D W SI ++
Sbjct: 363 TVDVYDGVKDQWTSIASM 380
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 256 bits (653), Expect = 5e-68
Identities = 171/541 (31%), Positives = 259/541 (47%), Gaps = 17/541 (3%)
Query: 36 LNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHP 95
+N LR Q L DV + A + HR VLAACS YF AMF+G + ES+ V +
Sbjct: 50 MNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRI-KEVDG 108
Query: 96 EVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLL 155
L +L+DY Y++ + + EEN + LL A +L+ QD++ C EFLE LHP NCLG+
Sbjct: 109 WTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAF 168
Query: 156 SDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAI 215
+D H CT L + +F + +E+FL L + V L+SS++L E V+E+ I
Sbjct: 169 ADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVI 228
Query: 216 NWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLK 275
W+++D R ++ L++ VRL LLP YL++ V E L+ K+ + EA++ L
Sbjct: 229 AWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLL 288
Query: 276 ILQNDGVVTSLCAR---PRKTGHALFLLGGQTFMCDK-LYLVDQKAKEIIPKADIPSPRK 331
+ ++ S+ R P + ++GGQ + + D K + A++PS R
Sbjct: 289 PTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRC 348
Query: 332 EFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLY 391
+ V+ GG V + V YD + ++W+ A M R G+A L LY
Sbjct: 349 RAGMVYMAGLVFAVGGFNGSLRV-RTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLY 407
Query: 392 VVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGG 451
VGG +TG L VE Y+ N+W VAP+ S+ V L+A GG
Sbjct: 408 AVGGFDGSTG---------LSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGG 458
Query: 452 -TSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG-DTEFSACSAY 509
S L V+CY+ N WT A VL N ++ +GG D S
Sbjct: 459 YDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVE 518
Query: 510 KFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSIT 569
++ T W +V D+ R + A LYVVGG G +++ Y+PT D W ++
Sbjct: 519 VYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVS 578
Query: 570 T 570
+
Sbjct: 579 S 579
Score = 70.5 bits (171), Expect = 4e-12
Identities = 54/176 (30%), Positives = 74/176 (42%), Gaps = 11/176 (6%)
Query: 316 KAKEIIPKADIPSPRKEFSACAIGCKVYITGGR-GSENGVSKDVWVYDTLHEEWSKAAPM 374
K+ E A + + R +G +Y GG G+ V Y+ EW+ A M
Sbjct: 427 KSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM 486
Query: 375 LVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGV 434
R G G L + LY VGGH P V K VE YDPT N W VA +
Sbjct: 487 STRRSGAGVGVLNNLLYAVGGHDG--------PLVR-KSVEVYDPTTNAWRQVADMNMCR 537
Query: 435 SNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVL 490
NA V + L+ GG S + L V+ Y+ ++WTV ++C R A +
Sbjct: 538 RNAGVCAVNGLLYVVGGDDGSCN-LASVEYYNPTTDKWTVVSSCMSTGRSYAGVTV 592
Score = 45.8 bits (107), Expect = 1e-04
Identities = 20/76 (26%), Positives = 39/76 (51%)
Query: 496 IMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTL 555
++GG + S ++ + +W +V ++ ++R V ++ VGG+ G R +T+
Sbjct: 315 VVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTV 374
Query: 556 DCYDPTLDVWNSITTV 571
D YDP D W S+ +
Sbjct: 375 DSYDPVKDQWTSVANM 390
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 256 bits (653), Expect = 5e-68
Identities = 171/541 (31%), Positives = 259/541 (47%), Gaps = 17/541 (3%)
Query: 36 LNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHP 95
+N LR Q L DV + A + HR VLAACS YF AMF+G + ES+ V +
Sbjct: 46 MNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRI-KEVDG 104
Query: 96 EVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLL 155
L +L+DY Y++ + + EEN + LL A +L+ QD++ C EFLE LHP NCLG+
Sbjct: 105 WTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAF 164
Query: 156 SDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAI 215
+D H CT L + +F + +E+FL L + V L+SS++L E V+E+ I
Sbjct: 165 ADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVI 224
Query: 216 NWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLK 275
W+++D R ++ L++ VRL LLP YL++ V E L+ K+ + EA++ L
Sbjct: 225 AWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLL 284
Query: 276 ILQNDGVVTSLCAR---PRKTGHALFLLGGQTFMCDK-LYLVDQKAKEIIPKADIPSPRK 331
+ ++ S+ R P + ++GGQ + + D K + A++PS R
Sbjct: 285 PTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRC 344
Query: 332 EFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLY 391
+ V+ GG V + V YD + ++W+ A M R G+A L LY
Sbjct: 345 RAGMVYMAGLVFAVGGFNGSLRV-RTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLY 403
Query: 392 VVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGG 451
VGG +TG L VE Y+ N+W VAP+ S+ V L+A GG
Sbjct: 404 AVGGFDGSTG---------LSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGG 454
Query: 452 -TSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG-DTEFSACSAY 509
S L V+CY+ N WT A VL N ++ +GG D S
Sbjct: 455 YDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVE 514
Query: 510 KFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSIT 569
++ T W +V D+ R + A LYVVGG G +++ Y+PT D W ++
Sbjct: 515 VYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVS 574
Query: 570 T 570
+
Sbjct: 575 S 575
Score = 70.5 bits (171), Expect = 4e-12
Identities = 54/176 (30%), Positives = 74/176 (42%), Gaps = 11/176 (6%)
Query: 316 KAKEIIPKADIPSPRKEFSACAIGCKVYITGGR-GSENGVSKDVWVYDTLHEEWSKAAPM 374
K+ E A + + R +G +Y GG G+ V Y+ EW+ A M
Sbjct: 423 KSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM 482
Query: 375 LVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGV 434
R G G L + LY VGGH P V K VE YDPT N W VA +
Sbjct: 483 STRRSGAGVGVLNNLLYAVGGHDG--------PLVR-KSVEVYDPTTNAWRQVADMNMCR 533
Query: 435 SNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVL 490
NA V + L+ GG S + L V+ Y+ ++WTV ++C R A +
Sbjct: 534 RNAGVCAVNGLLYVVGGDDGSCN-LASVEYYNPTTDKWTVVSSCMSTGRSYAGVTV 588
Score = 45.8 bits (107), Expect = 1e-04
Identities = 20/76 (26%), Positives = 39/76 (51%)
Query: 496 IMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTL 555
++GG + S ++ + +W +V ++ ++R V ++ VGG+ G R +T+
Sbjct: 311 VVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTV 370
Query: 556 DCYDPTLDVWNSITTV 571
D YDP D W S+ +
Sbjct: 371 DSYDPVKDQWTSVANM 386
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 251 bits (640), Expect = 2e-66
Identities = 163/544 (29%), Positives = 270/544 (49%), Gaps = 43/544 (7%)
Query: 36 LNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHP 95
L LR + TDV+L + F CHR VLAA S YF AMF LKE + + +
Sbjct: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIII-KGVDA 120
Query: 96 EVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLL 155
E + LLDY Y+S+ +I ++N + +LEA ++ +F + DACA FL + L+P NC+G+L L
Sbjct: 121 ETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRL 180
Query: 156 SDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAI 215
+D H L + + NF I +E+FL LP D + +L S++L +E V+E+ +
Sbjct: 181 ADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVM 240
Query: 216 NWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLK 275
+W+ + +R C LP +L+ VRL LL Y +E V + LI + + +++EA ++
Sbjct: 241 SWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEA---RMY 297
Query: 276 ILQNDGVVTSLCARPRK---TGHALFLLGGQTFMCDKLYLVD------------QKAKEI 320
L + +++ +PR ++GG T D+ ++ + + AK
Sbjct: 298 HLSGNEIISER-TKPRMHEFQSEVFMIIGGCT--KDERFVAEVTCLDPLRRSRLEVAKLP 354
Query: 321 IPKADIPSPRK---EFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVA 377
+ + ++ S K EF+ + +VYI+GG+ +++ DVW Y++ +W + + +
Sbjct: 355 LTEHELESENKKWVEFACVTLKNEVYISGGKETQH----DVWKYNSSINKWIQIEYLNIG 410
Query: 378 RFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNA 437
R+ H L +YV+GG + VE YDP N W+ APL VS+
Sbjct: 411 RWRHKMVVLGGKVYVIGGFDGLQ---------RINNVETYDPFHNCWSEAAPLLVHVSSF 461
Query: 438 AVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIM 497
A S K KL+ GG K QCYD N+W++ A P + A ++I+++
Sbjct: 462 AATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVV 521
Query: 498 GGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQR-CKTLD 556
GG + + Y ++ W V ++ +R SC N+LY+ GG T+
Sbjct: 522 GG----AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVL 577
Query: 557 CYDP 560
C+DP
Sbjct: 578 CWDP 581
Score = 55.8 bits (133), Expect = 1e-07
Identities = 45/191 (23%), Positives = 77/191 (40%), Gaps = 29/191 (15%)
Query: 418 DPTINKWTMVAPLREG-----VSNAAVVSAKLK----------LFAFGGTSVSHDKLPKV 462
DP I + V PL + +S ++S + K GG + + +V
Sbjct: 278 DPLIRQCPEVFPLLQEARMYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEV 337
Query: 463 QCYDQCENRWTVPATCP----------QPWRYTAAAVLGNQIFIMGGDTEFSACSAYKFN 512
C D A P + W A L N+++I GG + +K+N
Sbjct: 338 TCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKE--TQHDVWKYN 395
Query: 513 SETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTVP 572
S +W ++ + R V G K+YV+GG+ G+QR ++ YDP + W+ P
Sbjct: 396 SSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSE--AAP 453
Query: 573 YSLIPTAFVST 583
+ ++F +T
Sbjct: 454 LLVHVSSFAAT 464
Score = 46.2 bits (108), Expect = 8e-05
Identities = 38/142 (26%), Positives = 61/142 (42%), Gaps = 16/142 (11%)
Query: 438 AVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWT-VPATCPQPWRYTAAAVLGNQIFI 496
A V+ K +++ GG HD V Y+ N+W + WR+ VLG ++++
Sbjct: 371 ACVTLKNEVYISGGKETQHD----VWKYNSSINKWIQIEYLNIGRWRHKMV-VLGGKVYV 425
Query: 497 MGGDTEFSACSAYKFNSETYQ-----WTKVGDVTAKRMSCHAVASGNKLYVVGGY-FGIQ 550
+GG + N ETY W++ + S A + KLYV+GG G
Sbjct: 426 IGGFDGLQRIN----NVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKL 481
Query: 551 RCKTLDCYDPTLDVWNSITTVP 572
CYDP+ + W+ +P
Sbjct: 482 ATDKTQCYDPSTNKWSLKAAMP 503
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 250 bits (639), Expect = 2e-66
Identities = 164/545 (30%), Positives = 272/545 (49%), Gaps = 31/545 (5%)
Query: 37 NLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPE 96
N LR ++L DV+L AG+R P HR VL++ S YF AMF+ ++E++ E+ + + P
Sbjct: 166 NYLRHKQL-CDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEG-VEPN 223
Query: 97 VLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLS 156
L L+ YAY+ R+ + E+N E LL +L+ + +AC +FL K LHP+NCLG+ +
Sbjct: 224 SLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFA 283
Query: 157 DAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAIN 216
DA CT L++++ + +F + +N++F+ LP + +LL+S+++ +E + + +
Sbjct: 284 DAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLT 343
Query: 217 WISYDLKKRYCYLPELLQTVRLALLPAIYL--MENVAMEELITKQRKSKEIVEEAIRCKL 274
W+ +DL++R L +LL +RL LL +L MEN L + ++++ EA++ L
Sbjct: 344 WVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMEN---NVLFRDDIECQKLIMEAMKYHL 400
Query: 275 KILQNDGVVTSLCARPRK-TGHALFLLGG--QTFMCDKLYLVDQKAKEIIPKADIPSPRK 331
+ + ++ S +PRK T LF +GG T + D + P A++ R
Sbjct: 401 -LPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRL 459
Query: 332 EFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLY 391
+F + K+Y+ GGR ++ V Y+ + WS PM R G G A L+ +Y
Sbjct: 460 QFGVAVLDDKLYVVGGRDGLKTLN-TVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMY 518
Query: 392 VVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGG 451
VGGH + L VE +DP +W VA + S V KL+A GG
Sbjct: 519 AVGGHDGWS---------YLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG 569
Query: 452 TSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG--------DTEF 503
S L V+C+D N+WT+ A + ++ +GG +
Sbjct: 570 RDGS-SCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRL 628
Query: 504 SACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLD 563
S C +++ +T WT V ++ R + G+KLY VGGY G T++ YDP +
Sbjct: 629 SDC-VERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTN 687
Query: 564 VWNSI 568
W +
Sbjct: 688 EWTQV 692
Score = 55.5 bits (132), Expect = 1e-07
Identities = 49/175 (28%), Positives = 66/175 (37%), Gaps = 45/175 (25%)
Query: 314 DQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAP 373
D +A++ A + +PR + K+Y GGR + + K V +D +W+ A
Sbjct: 536 DPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCL-KSVECFDPHTNKWTLCAQ 594
Query: 374 MLVARFGHGSAELKHCLYVVGGHTAATGCLP--------------------ASPSVS--- 410
M R G G LY +GGH A L AS S+S
Sbjct: 595 MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDA 654
Query: 411 ---------------------LKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKL 444
L VE YDP N+WT VAPL G + A VV+ KL
Sbjct: 655 VGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 709
Score = 51.6 bits (122), Expect = 2e-06
Identities = 36/140 (25%), Positives = 61/140 (43%), Gaps = 4/140 (2%)
Query: 446 LFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSA 505
LFA GG S ++ YD N WT A AVL ++++++GG
Sbjct: 423 LFAVGGMD-STKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKT 481
Query: 506 CSAYK-FNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDV 564
+ + +N +T W+ + ++ R +Y VGG+ G T++ +DP
Sbjct: 482 LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQ 541
Query: 565 WNSITTV--PYSLIPTAFVS 582
WN + T+ P S + A +S
Sbjct: 542 WNFVATMSTPRSTVGVAVLS 561
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 250 bits (639), Expect = 2e-66
Identities = 164/545 (30%), Positives = 272/545 (49%), Gaps = 31/545 (5%)
Query: 37 NLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPE 96
N LR ++L DV+L AG+R P HR VL++ S YF AMF+ ++E++ E+ + + P
Sbjct: 212 NYLRHKQL-CDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEG-VEPN 269
Query: 97 VLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLS 156
L L+ YAY+ R+ + E+N E LL +L+ + +AC +FL K LHP+NCLG+ +
Sbjct: 270 SLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFA 329
Query: 157 DAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAIN 216
DA CT L++++ + +F + +N++F+ LP + +LL+S+++ +E + + +
Sbjct: 330 DAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLT 389
Query: 217 WISYDLKKRYCYLPELLQTVRLALLPAIYL--MENVAMEELITKQRKSKEIVEEAIRCKL 274
W+ +DL++R L +LL +RL LL +L MEN L + ++++ EA++ L
Sbjct: 390 WVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMEN---NVLFRDDIECQKLIMEAMKYHL 446
Query: 275 KILQNDGVVTSLCARPRK-TGHALFLLGG--QTFMCDKLYLVDQKAKEIIPKADIPSPRK 331
+ + ++ S +PRK T LF +GG T + D + P A++ R
Sbjct: 447 -LPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRL 505
Query: 332 EFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLY 391
+F + K+Y+ GGR ++ V Y+ + WS PM R G G A L+ +Y
Sbjct: 506 QFGVAVLDDKLYVVGGRDGLKTLN-TVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMY 564
Query: 392 VVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGG 451
VGGH + L VE +DP +W VA + S V KL+A GG
Sbjct: 565 AVGGHDGWS---------YLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG 615
Query: 452 TSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG--------DTEF 503
S L V+C+D N+WT+ A + ++ +GG +
Sbjct: 616 RDGS-SCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRL 674
Query: 504 SACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLD 563
S C +++ +T WT V ++ R + G+KLY VGGY G T++ YDP +
Sbjct: 675 SDC-VERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTN 733
Query: 564 VWNSI 568
W +
Sbjct: 734 EWTQV 738
Score = 55.5 bits (132), Expect = 1e-07
Identities = 49/175 (28%), Positives = 66/175 (37%), Gaps = 45/175 (25%)
Query: 314 DQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAP 373
D +A++ A + +PR + K+Y GGR + + K V +D +W+ A
Sbjct: 582 DPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCL-KSVECFDPHTNKWTLCAQ 640
Query: 374 MLVARFGHGSAELKHCLYVVGGHTAATGCLP--------------------ASPSVS--- 410
M R G G LY +GGH A L AS S+S
Sbjct: 641 MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDA 700
Query: 411 ---------------------LKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKL 444
L VE YDP N+WT VAPL G + A VV+ KL
Sbjct: 701 VGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 755
Score = 51.6 bits (122), Expect = 2e-06
Identities = 36/140 (25%), Positives = 61/140 (43%), Gaps = 4/140 (2%)
Query: 446 LFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSA 505
LFA GG S ++ YD N WT A AVL ++++++GG
Sbjct: 469 LFAVGGMD-STKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKT 527
Query: 506 CSAYK-FNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDV 564
+ + +N +T W+ + ++ R +Y VGG+ G T++ +DP
Sbjct: 528 LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQ 587
Query: 565 WNSITTV--PYSLIPTAFVS 582
WN + T+ P S + A +S
Sbjct: 588 WNFVATMSTPRSTVGVAVLS 607
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 250 bits (638), Expect = 3e-66
Identities = 160/547 (29%), Positives = 266/547 (48%), Gaps = 20/547 (3%)
Query: 25 KSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQD 84
K Y D+ + ++ +RQ+ L D++LH + H+ VLA+CS YF AMF+ + ES+
Sbjct: 72 KRHYHDAFVA-MSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQ 130
Query: 85 SEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNL 144
+ V + I P+ L+ L+ +AY++ +++ E N ++LL A +L+ +RDAC +FL L
Sbjct: 131 THVTL-HDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQL 189
Query: 145 HPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELET 204
P+NCLG+ +DAH C+ L + + R L +F + K E+F+ LP V++L+SS+ L
Sbjct: 190 DPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNV 249
Query: 205 EDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKE 264
E VY + ++W+ +D+ R ++P L++ VRL LL +L+ +V E L+ K+
Sbjct: 250 PSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKD 309
Query: 265 IVEEAIRCKLKILQNDGVVTSLCARPRK---TGHALFLLGGQTFMC--DKLYLVDQKAKE 319
++ EA++ L + + GV+ + RPR+ G LF +GG + D +
Sbjct: 310 LLIEALKFHL-LPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDR 368
Query: 320 IIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARF 379
A + + R A+G ++Y GG + ++ V YD + W M R
Sbjct: 369 WHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLA-TVESYDPVTNTWQPEVSMGTRRS 427
Query: 380 GHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAV 439
G A L LY GG+ A+ L E YDP WT VA + V
Sbjct: 428 CLGVAALHGLLYSAGGYDGAS---------CLNSAERYDPLTGTWTSVAAMSTRRRYVRV 478
Query: 440 VSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG 499
+ L+A GG S L V+ Y+ N W+ A+ AVL +++ GG
Sbjct: 479 ATLDGNLYAVGGYD-SSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGG 537
Query: 500 DTEFSAC-SAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCY 558
+ S S +++ + W V + +R + VA LY VGG G +++ Y
Sbjct: 538 NDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKY 597
Query: 559 DPTLDVW 565
+P + W
Sbjct: 598 NPRTNKW 604
Score = 65.9 bits (159), Expect = 1e-10
Identities = 41/158 (25%), Positives = 69/158 (43%), Gaps = 2/158 (1%)
Query: 415 EHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTV 474
E YD ++W +VA + + V + +L+A GG + D L V+ YD N W
Sbjct: 360 EAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSD-LATVESYDPVTNTWQP 418
Query: 475 PATCPQPWRYTAAAVLGNQIFIMGG-DTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHA 533
+ A L ++ GG D SA +++ T WT V ++ +R
Sbjct: 419 EVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRV 478
Query: 534 VASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTV 571
LY VGGY T++ Y+P ++VW+ + ++
Sbjct: 479 ATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASM 516
Score = 44.3 bits (103), Expect = 3e-04
Identities = 32/126 (25%), Positives = 50/126 (39%), Gaps = 10/126 (7%)
Query: 322 PKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGH 381
P A + S R + +Y+ GG + ++ V Y W APM + R H
Sbjct: 512 PVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNS-VERYSPKAGAWESVAPMNIRRSTH 570
Query: 382 GSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVS 441
+ LY VGG+ ++ SL +E Y+P NKW + + S+ V
Sbjct: 571 DLVAMDGWLYAVGGNDGSS---------SLNSIEKYNPRTNKWVAASCMFTRRSSVGVAV 621
Query: 442 AKLKLF 447
+L F
Sbjct: 622 LELLNF 627
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 248 bits (633), Expect = 1e-65
Identities = 160/552 (28%), Positives = 262/552 (47%), Gaps = 17/552 (3%)
Query: 26 SSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDS 85
+++A S+L +N LR+ DV L + FP HR VLAACS YF AMF+ L E
Sbjct: 13 NTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKP 72
Query: 86 EVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLH 145
V+ + +E+LLD+ Y+ V + EN + LL A +L+ + ++ AC EFLE L
Sbjct: 73 YVDIQG-LTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLD 131
Query: 146 PTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETE 205
P+NCLG+ ++ H C L + + +F + ++E+F+ L Q V +L+ +E++ +
Sbjct: 132 PSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVD 191
Query: 206 DERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEI 265
E V+E+ INW+ + K+R LP LLQ VR+ LL Y+ + + E I + +++
Sbjct: 192 SEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDL 251
Query: 266 VEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLLGG---QTFMCDKLYLVDQKAKEIIP 322
V+EA + L+ + L ++GG Q D + D K +E
Sbjct: 252 VDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSF 311
Query: 323 KADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEE--WSKAAPMLVARFG 380
I R+ ++ ++ ++Y+ GG + +S + T E+ W APM V R
Sbjct: 312 LPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGL 371
Query: 381 HGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVV 440
G+ L +YV GG S +E YDP I++W+M+ ++ A +V
Sbjct: 372 AGATTLGDMIYVSGGFDG---------SRRHTSMERYDPNIDQWSMLGDMQTAREGAGLV 422
Query: 441 SAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG- 499
A ++ GG + L V+ YD WT A+L + I+++GG
Sbjct: 423 VASGVIYCLGGYD-GLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGF 481
Query: 500 DTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYD 559
D S +N T WT V +T R A +LY + GY G +++CYD
Sbjct: 482 DGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYD 541
Query: 560 PTLDVWNSITTV 571
P +D W +T++
Sbjct: 542 PIIDSWEVVTSM 553
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 248 bits (633), Expect = 1e-65
Identities = 169/553 (30%), Positives = 263/553 (47%), Gaps = 31/553 (5%)
Query: 28 YADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEV 87
+++ +L LNLLRQ D++L G+ H+ VLA+ S YF+AMF+G L E ++SEV
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
Query: 88 NFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPT 147
F I L+ +++YAY+ V I+++ ESLL A ++L+ + + C FLE L P
Sbjct: 77 EFQ-CIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPG 135
Query: 148 NCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDE 207
NC+G+ ++ + C LY + + NF+ + + E+F +L + +++S++ L E
Sbjct: 136 NCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATE 195
Query: 208 RLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVE 267
V+ + +WI YD+++R YL +LL +VRL LL +L LI R K ++
Sbjct: 196 ETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLN 255
Query: 268 EAIRCKLKILQNDGVVTSLCARPRKTGHALFLLGGQT--FMC-DKLYLVDQKAKEIIPKA 324
EA++ T L RPR L +GG++ F C D + + + I A
Sbjct: 256 EALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLA 315
Query: 325 DIPSPRKEFSACAIGCKVYITGG-----------RGSENGVSKDVWVYDTLHEEWSKAAP 373
+ PR EF C + KVY+ GG R EN V + W DT W+
Sbjct: 316 PLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSV--ECWNPDT--NTWTSLER 371
Query: 374 MLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREG 433
M +R G L LY +GG+ + L+ VE Y P I KW VAP+
Sbjct: 372 MNESRSTLGVVVLAGELYALGGYDGQS---------YLQSVEKYIPKIRKWQPVAPMTTT 422
Query: 434 VSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQ 493
S A ++A GG +H + V+ YD ++ W + A+ + V+
Sbjct: 423 RSCFAAAVLDGMIYAIGGYGPAH--MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGF 480
Query: 494 IFIMGGDTEFSACSAY-KFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRC 552
IF++GG S S+ +++ QWT + R A N LYVVGG+ G
Sbjct: 481 IFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYL 540
Query: 553 KTLDCYDPTLDVW 565
T+ YDP D W
Sbjct: 541 NTVQKYDPISDTW 553
Score = 59.3 bits (142), Expect = 1e-08
Identities = 45/192 (23%), Positives = 77/192 (40%), Gaps = 21/192 (10%)
Query: 390 LYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAF 449
L VGG + CL + VE Y P + W +APL + K++
Sbjct: 285 LCAVGGKSGLFACLDS--------VEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVI 336
Query: 450 GGTSVS---------HDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG- 499
GG + + H+ V+C++ N WT + VL +++ +GG
Sbjct: 337 GGIATNVRPGVTIRKHEN--SVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGY 394
Query: 500 DTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYD 559
D + S K+ + +W V +T R A +Y +GGY G +++ YD
Sbjct: 395 DGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYD 453
Query: 560 PTLDVWNSITTV 571
P+ D W + ++
Sbjct: 454 PSKDSWEMVASM 465
>gi|194097389 kelch-like 38 [Homo sapiens]
Length = 581
Score = 244 bits (624), Expect = 1e-64
Identities = 173/581 (29%), Positives = 275/581 (47%), Gaps = 36/581 (6%)
Query: 17 SINIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFS 76
S++ LF ++ +L LN LRQ R+ TDV + AG R PCHR VLA+ S YF AMF
Sbjct: 5 SLDGLLFKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFC 64
Query: 77 GGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDAC 136
+E +++V I P L+ ++ Y Y+ I +N ++EA ML+F + +AC
Sbjct: 65 SSFREKSEAKVQL-KGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEAC 123
Query: 137 AEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQL 196
+ +L+ L P+NCLGM+ LS+ C L + + + L++F + + D +L +
Sbjct: 124 SSYLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDY 183
Query: 197 LSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELI 256
L + L E+E+ V+E+ + WI +DL+ R Y+ EL + VRL + + +A + L+
Sbjct: 184 LGDDGLCGEEEK-VFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALL 242
Query: 257 TKQRKSKEIVEEAIRCKLKILQNDGVVTSLC-----ARPRKT-GHALFLLGG----QTFM 306
+ I+E A K ++ G C PR + L LLGG Q
Sbjct: 243 QSSPACQIILETA---KRQMFSLCGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTT 299
Query: 307 CDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENG---VSKDVWVYDT 363
D L L ++ + A +P+ + SA + +Y+ GG +G VS +V+++
Sbjct: 300 RDVL-LYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSL 358
Query: 364 LHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINK 423
+W PMLVAR+ H S K+ ++ +GG + +E YD N
Sbjct: 359 KLNQWRLGEPMLVARYSHRSTAHKNFIFSIGG--------IGEGQELMGSMERYDSICNV 410
Query: 424 WTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWR 483
W +A + GV + AV +L+ FGG + + + +Q Y N W T
Sbjct: 411 WESMASMPVGVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNV 470
Query: 484 YTAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVV 543
A VLG +I I+GG T ++ ++ ++ K D+ +RM A GNKLYV
Sbjct: 471 CAPAVVLGERIVIVGGYTR----RILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVT 526
Query: 544 GGY-----FGIQRCKTLDCYDPTLDVWNSITTVPYSLIPTA 579
GG I+ + DCYDP D W S +P+ L A
Sbjct: 527 GGRRLTTDCNIEDSASFDCYDPETDTWTSQGQLPHKLFDHA 567
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 243 bits (621), Expect = 3e-64
Identities = 162/553 (29%), Positives = 273/553 (49%), Gaps = 24/553 (4%)
Query: 23 FHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKES 82
FH ++A+ L + +++ DVLL AG+ P HR VL+A S YF AMF+ + E+
Sbjct: 159 FHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEA 218
Query: 83 QDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEK 142
+ EV + + P L L+ YAY+ + + E+ ESLL A +L+ + D C+ FL K
Sbjct: 219 KQEEVRMEG-VDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIK 277
Query: 143 NLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEEL 202
LHP+NCLG+ DA CT+L ++ + + +F + KN++FL LP + + +LL S+++
Sbjct: 278 QLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDI 337
Query: 203 ETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKS 262
DE ++ + + W+ +D++ R L LL +RL LLP L+ ++ + T +
Sbjct: 338 NVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPP-QLLADLETSSMFTGDLEC 396
Query: 263 KEIVEEAIRCKLKILQNDGVVTSLCARPRK-TGHALFLLGGQTFM--CDKLYLVDQKAKE 319
++++ EA++ L + + ++ S +PRK T AL+ +GG M + D +
Sbjct: 397 QKLLMEAMKYHL-LPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNS 455
Query: 320 IIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARF 379
+ + R +F I K+Y+ GGR ++ V ++ + + W+ PM R
Sbjct: 456 WLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLN-TVECFNPVGKIWTVMPPMSTHRH 514
Query: 380 GHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAV 439
G G A L+ +Y VGGH + L VE +DP +W VA + S V
Sbjct: 515 GLGVATLEGPMYAVGGHDGWS---------YLNTVERWDPEGRQWNYVASMSTPRSTVGV 565
Query: 440 VSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG 499
V+ KL+A GG S L ++ +D N+W++ A + A ++++GG
Sbjct: 566 VALNNKLYAIGGRDGS-SCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGG 624
Query: 500 DTEFSA--CSAYKFNSETY-----QWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRC 552
++ CS E Y W+ V ++ R + G+KLYVVGGY G
Sbjct: 625 HDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYL 684
Query: 553 KTLDCYDPTLDVW 565
T++ YD + W
Sbjct: 685 NTVESYDAQRNEW 697
Score = 63.2 bits (152), Expect = 7e-10
Identities = 46/178 (25%), Positives = 71/178 (39%), Gaps = 11/178 (6%)
Query: 390 LYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAF 449
LY VGG A G +E YD N W + + V KL+
Sbjct: 431 LYAVGGMDAMKGTTT---------IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVV 481
Query: 450 GGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSACSAY 509
GG L V+C++ WTV A L ++ +GG +S +
Sbjct: 482 GGRD-GLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV 540
Query: 510 -KFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWN 566
+++ E QW V ++ R + VA NKLY +GG G K+++ +DP + W+
Sbjct: 541 ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWS 598
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/127 (22%), Positives = 51/127 (40%), Gaps = 2/127 (1%)
Query: 446 LFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSA 505
L+A GG ++ YD N W T AV+ N+++++GG
Sbjct: 431 LYAVGGMDAMKGTTT-IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKT 489
Query: 506 CSAYK-FNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDV 564
+ + FN WT + ++ R +Y VGG+ G T++ +DP
Sbjct: 490 LNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQ 549
Query: 565 WNSITTV 571
WN + ++
Sbjct: 550 WNYVASM 556
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 243 bits (621), Expect = 3e-64
Identities = 162/553 (29%), Positives = 273/553 (49%), Gaps = 24/553 (4%)
Query: 23 FHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKES 82
FH ++A+ L + +++ DVLL AG+ P HR VL+A S YF AMF+ + E+
Sbjct: 159 FHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEA 218
Query: 83 QDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEK 142
+ EV + + P L L+ YAY+ + + E+ ESLL A +L+ + D C+ FL K
Sbjct: 219 KQEEVRMEG-VDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIK 277
Query: 143 NLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEEL 202
LHP+NCLG+ DA CT+L ++ + + +F + KN++FL LP + + +LL S+++
Sbjct: 278 QLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDI 337
Query: 203 ETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKS 262
DE ++ + + W+ +D++ R L LL +RL LLP L+ ++ + T +
Sbjct: 338 NVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPP-QLLADLETSSMFTGDLEC 396
Query: 263 KEIVEEAIRCKLKILQNDGVVTSLCARPRK-TGHALFLLGGQTFM--CDKLYLVDQKAKE 319
++++ EA++ L + + ++ S +PRK T AL+ +GG M + D +
Sbjct: 397 QKLLMEAMKYHL-LPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNS 455
Query: 320 IIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARF 379
+ + R +F I K+Y+ GGR ++ V ++ + + W+ PM R
Sbjct: 456 WLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLN-TVECFNPVGKIWTVMPPMSTHRH 514
Query: 380 GHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAV 439
G G A L+ +Y VGGH + L VE +DP +W VA + S V
Sbjct: 515 GLGVATLEGPMYAVGGHDGWS---------YLNTVERWDPEGRQWNYVASMSTPRSTVGV 565
Query: 440 VSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG 499
V+ KL+A GG S L ++ +D N+W++ A + A ++++GG
Sbjct: 566 VALNNKLYAIGGRDGS-SCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGG 624
Query: 500 DTEFSA--CSAYKFNSETY-----QWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRC 552
++ CS E Y W+ V ++ R + G+KLYVVGGY G
Sbjct: 625 HDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYL 684
Query: 553 KTLDCYDPTLDVW 565
T++ YD + W
Sbjct: 685 NTVESYDAQRNEW 697
Score = 63.2 bits (152), Expect = 7e-10
Identities = 46/178 (25%), Positives = 71/178 (39%), Gaps = 11/178 (6%)
Query: 390 LYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAF 449
LY VGG A G +E YD N W + + V KL+
Sbjct: 431 LYAVGGMDAMKGTTT---------IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVV 481
Query: 450 GGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSACSAY 509
GG L V+C++ WTV A L ++ +GG +S +
Sbjct: 482 GGRD-GLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV 540
Query: 510 -KFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWN 566
+++ E QW V ++ R + VA NKLY +GG G K+++ +DP + W+
Sbjct: 541 ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWS 598
Score = 48.1 bits (113), Expect = 2e-05
Identities = 45/165 (27%), Positives = 57/165 (34%), Gaps = 45/165 (27%)
Query: 324 ADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGS 383
A + +PR A+ K+Y GGR + + K + +D +WS APM R G G
Sbjct: 554 ASMSTPRSTVGVVALNNKLYAIGGRDGSSCL-KSMEYFDPHTNKWSLCAPMSKRRGGVGV 612
Query: 384 AELKHCLYVVGGHTAATG--CLPASPSVS------------------------------- 410
A LYVVGGH A C S V
Sbjct: 613 ATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKL 672
Query: 411 -----------LKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKL 444
L VE YD N+W P+ G + A VV KL
Sbjct: 673 YVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVKL 717
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/127 (22%), Positives = 51/127 (40%), Gaps = 2/127 (1%)
Query: 446 LFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSA 505
L+A GG ++ YD N W T AV+ N+++++GG
Sbjct: 431 LYAVGGMDAMKGTTT-IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKT 489
Query: 506 CSAYK-FNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDV 564
+ + FN WT + ++ R +Y VGG+ G T++ +DP
Sbjct: 490 LNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQ 549
Query: 565 WNSITTV 571
WN + ++
Sbjct: 550 WNYVASM 556
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 240 bits (612), Expect = 3e-63
Identities = 174/565 (30%), Positives = 273/565 (48%), Gaps = 44/565 (7%)
Query: 23 FHKSSYADSVLTHLNLLRQQRLFTDVLLHA-GNRTFPCHRAVLAACSRYFEAMFSGGLKE 81
F ++A S+L L+ LR +R F DV L A G R FP HRAVLAA S YF AMF+G L+E
Sbjct: 12 FSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRE 71
Query: 82 SQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLE 141
S+ V + + P++L+LLLD++Y+ RV ++ +NAE LL A D+L+F +++AC FL+
Sbjct: 72 SRAERVRL-HGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
Query: 142 KNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEE 201
+ L NCL M ++A C+ L + R L + + E +LP +++ L +
Sbjct: 131 QQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGA-EQLERLPLARLLRYLRDDG 189
Query: 202 LETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRK 261
L E Y+ A+ W+ D +R + P+LL+ VRL + YL+ +V E L+ +
Sbjct: 190 LCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPP 249
Query: 262 SKEIVEEAIRCKLKILQNDGVVTSLCARPR---KTGHA--LFLLGGQTFMCDKLYLVD-- 314
++ EA + + D C R R TG A L L+GG CD+L VD
Sbjct: 250 CLRLLREA--RDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCY 307
Query: 315 -QKAKEIIPKADIPSP-RKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAA 372
+ + A+ P +S A+G +Y+TGG + VW Y++ EW++ A
Sbjct: 308 NPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSR-LYDCVWRYNSSVNEWAEVA 366
Query: 373 PMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLRE 432
PML AR H S+ L LYVV + E YD T + W + P+
Sbjct: 367 PMLKAREYHSSSVLDGLLYVVAADS----------------TERYDHTTDSWEALQPMTY 410
Query: 433 GVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQ--PWRYT--AAA 488
+ N + + + +L+A G S++ + +QCYD + W++ C Q PW + A
Sbjct: 411 PMDNCSTTACRGRLYAIG--SLAGKETMVMQCYDPDTDLWSL-VDCGQLPPWSFAPKTAT 467
Query: 489 VLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFG 548
+ G F+ E +N +W K+ + + G KLYV GGY
Sbjct: 468 LNGLMYFVRDDSAEVDV-----YNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDN 522
Query: 549 -IQRCKTLDCYDPTLDVWNSITTVP 572
+ ++ YDP W+ + +P
Sbjct: 523 TFELSDVVEAYDPETRAWSVVGRLP 547
Score = 44.3 bits (103), Expect = 3e-04
Identities = 35/134 (26%), Positives = 55/134 (41%), Gaps = 13/134 (9%)
Query: 446 LFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWR--YTAAAVLGNQIFIMGGD--T 501
L GG D+L V CY+ +W A P Y+ A LGN I++ GG +
Sbjct: 288 LVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVA-LGNDIYVTGGSDGS 346
Query: 502 EFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPT 561
C +++NS +W +V + R + LYVV + + YD T
Sbjct: 347 RLYDC-VWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAA-------DSTERYDHT 398
Query: 562 LDVWNSITTVPYSL 575
D W ++ + Y +
Sbjct: 399 TDSWEALQPMTYPM 412
Score = 35.4 bits (80), Expect = 0.15
Identities = 17/69 (24%), Positives = 32/69 (46%)
Query: 413 QVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRW 472
+V+ Y+PT N+W + + + ++ KL+ GG + + V+ YD W
Sbjct: 481 EVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAW 540
Query: 473 TVPATCPQP 481
+V P+P
Sbjct: 541 SVVGRLPEP 549
Score = 30.4 bits (67), Expect = 4.8
Identities = 16/53 (30%), Positives = 24/53 (45%)
Query: 334 SACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAEL 386
S +G K+Y++GG + +S V YD WS + F HGS +
Sbjct: 506 SLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSI 558
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 239 bits (609), Expect = 7e-63
Identities = 176/593 (29%), Positives = 280/593 (47%), Gaps = 46/593 (7%)
Query: 21 YLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLK 80
Y F + +L LN R+ + FTD+ + R F H+ VLA+CS YF+ + ++
Sbjct: 304 YEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQ 363
Query: 81 ES-----QDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDA 135
+S + E+ N + +VLELLL++ Y+ ++I+ NA++LLEA +F
Sbjct: 364 DSGQGGREKLELVLSN-LQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKV 422
Query: 136 CAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQ 195
C FLEK L +NCLG+L +++A QC++LY ++ L F + E+ L + +D +
Sbjct: 423 CVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIA 482
Query: 196 LLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEEL 255
+S++ L T+ E LVYE+ I WI D R Y ELL VRL + YL+ V EEL
Sbjct: 483 YVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEEL 542
Query: 256 ITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKT---GHALFLLGGQTFM-CDKLY 311
I +++V EA R + + T RPR + + L+GG+ + +
Sbjct: 543 IKSSEACRDLVNEAKRYHMLPHARQEMQTPR-TRPRLSAGVAEVIVLVGGRQMVGMTQRS 601
Query: 312 LV-----DQKAKEIIPKADIP-SPRKEFSACAIGCKVYITGGRGSENGVS-KDVWVYDTL 364
LV + + + P A +P R+ FS + G +Y++G G E+GV+ DVW Y +L
Sbjct: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSG--GMESGVTLADVWCYMSL 659
Query: 365 HEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKW 424
+ W+ + M V R H S +Y +GG A ++ VE YD N+W
Sbjct: 660 LDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAG---------NVDHVERYDTITNQW 710
Query: 425 TMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRY 484
VAPL + V +AA K++ FGG + + +Q Y N W+ + +Y
Sbjct: 711 EAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKY 770
Query: 485 TAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTA------KRMSCHAVASGN 538
A L +FI+GG AY + Y K G++ A R C AV
Sbjct: 771 APAVTLNGFVFILGG--------AYARATTIYDPEK-GNIKAGPNMNHSRQFCSAVVLDG 821
Query: 539 KLYVVGGYFGIQ--RCKTLDCYDPTLDVWNSITTVPYSLIPTAFVSTWKHLPS 589
K+Y GG + ++ Y+PT + W + +P + V K++ S
Sbjct: 822 KIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVIKKYIQS 874
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 239 bits (609), Expect = 7e-63
Identities = 176/593 (29%), Positives = 280/593 (47%), Gaps = 46/593 (7%)
Query: 21 YLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLK 80
Y F + +L LN R+ + FTD+ + R F H+ VLA+CS YF+ + ++
Sbjct: 304 YEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQ 363
Query: 81 ES-----QDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDA 135
+S + E+ N + +VLELLL++ Y+ ++I+ NA++LLEA +F
Sbjct: 364 DSGQGGREKLELVLSN-LQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKV 422
Query: 136 CAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQ 195
C FLEK L +NCLG+L +++A QC++LY ++ L F + E+ L + +D +
Sbjct: 423 CVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIA 482
Query: 196 LLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEEL 255
+S++ L T+ E LVYE+ I WI D R Y ELL VRL + YL+ V EEL
Sbjct: 483 YVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEEL 542
Query: 256 ITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKT---GHALFLLGGQTFM-CDKLY 311
I +++V EA R + + T RPR + + L+GG+ + +
Sbjct: 543 IKSSEACRDLVNEAKRYHMLPHARQEMQTPR-TRPRLSAGVAEVIVLVGGRQMVGMTQRS 601
Query: 312 LV-----DQKAKEIIPKADIP-SPRKEFSACAIGCKVYITGGRGSENGVS-KDVWVYDTL 364
LV + + + P A +P R+ FS + G +Y++G G E+GV+ DVW Y +L
Sbjct: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSG--GMESGVTLADVWCYMSL 659
Query: 365 HEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKW 424
+ W+ + M V R H S +Y +GG A ++ VE YD N+W
Sbjct: 660 LDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAG---------NVDHVERYDTITNQW 710
Query: 425 TMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRY 484
VAPL + V +AA K++ FGG + + +Q Y N W+ + +Y
Sbjct: 711 EAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKY 770
Query: 485 TAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTA------KRMSCHAVASGN 538
A L +FI+GG AY + Y K G++ A R C AV
Sbjct: 771 APAVTLNGFVFILGG--------AYARATTIYDPEK-GNIKAGPNMNHSRQFCSAVVLDG 821
Query: 539 KLYVVGGYFGIQ--RCKTLDCYDPTLDVWNSITTVPYSLIPTAFVSTWKHLPS 589
K+Y GG + ++ Y+PT + W + +P + V K++ S
Sbjct: 822 KIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVIKKYIQS 874
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 234 bits (598), Expect = 1e-61
Identities = 161/537 (29%), Positives = 256/537 (47%), Gaps = 26/537 (4%)
Query: 39 LRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVL 98
+R+Q DV L G+ F HR VLAA YF AMF+ + E + E+ + P L
Sbjct: 31 IRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQG-MDPSAL 89
Query: 99 ELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDA 158
E L+++AY+ + I+++N +SLL L+ Q I+DAC FL + LHP NCLG+ ++
Sbjct: 90 EALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAET 149
Query: 159 HQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWI 218
C LY+ + +F + +E+FL LP + V++L+S +EL + E V+E+A+ W+
Sbjct: 150 MMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWV 209
Query: 219 SYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKILQ 278
YD ++R YLPELL +RL L +L + V ++L+ K +++V+EA L + +
Sbjct: 210 RYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHL-MPE 268
Query: 279 NDGVVTSLCARPR---KTGHALFLLGGQTFMCDKLYLV---DQKAKEIIPKADIPSPRKE 332
+ + RPR ++ +GG D L +V D A + + R
Sbjct: 269 RRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSR 328
Query: 333 FSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYV 392
+ +Y GG + +S V Y+ + W++ M R G+ L +YV
Sbjct: 329 VGVAVVNGLLYAIGGYDGQLRLS-TVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYV 387
Query: 393 VGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGT 452
GG+ + SL VE Y P +KWT+V + S A V + +++ GG
Sbjct: 388 CGGYDG---------NSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGG- 437
Query: 453 SVSHDKL---PKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG-DTEFSACSA 508
HD L V+ Y+ W A AA LG+++F+ GG D A
Sbjct: 438 ---HDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIA 494
Query: 509 YKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVW 565
++S QW + + +R VAS +LY VGGY G +++ YDP D W
Sbjct: 495 EMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCW 551
Score = 67.8 bits (164), Expect = 3e-11
Identities = 48/178 (26%), Positives = 76/178 (42%), Gaps = 10/178 (5%)
Query: 390 LYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAF 449
+Y VGG +A SL VE +DP N W P+ S V L+A
Sbjct: 290 IYAVGGLNSAGD--------SLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAI 341
Query: 450 GGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG-DTEFSACSA 508
GG +L V+ Y+ + WT + VL QI++ GG D S S
Sbjct: 342 GGYD-GQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSV 400
Query: 509 YKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWN 566
++ ET +WT V +++ R + ++YV GG+ G+Q +++ Y+ W+
Sbjct: 401 ETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWH 458
Score = 67.0 bits (162), Expect = 5e-11
Identities = 35/127 (27%), Positives = 60/127 (47%), Gaps = 1/127 (0%)
Query: 446 LFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG-DTEFS 504
++A GG + + D L V+ +D N W AV+ ++ +GG D +
Sbjct: 290 IYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLR 349
Query: 505 ACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDV 564
+ +N ET WT+VG + +KR + V ++YV GGY G +++ Y P D
Sbjct: 350 LSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDK 409
Query: 565 WNSITTV 571
W +T++
Sbjct: 410 WTVVTSM 416
Score = 44.7 bits (104), Expect = 2e-04
Identities = 29/109 (26%), Positives = 48/109 (44%), Gaps = 10/109 (9%)
Query: 322 PKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGH 381
P A + + R A ++G K+++ GG +G +Y ++ ++W PM R
Sbjct: 459 PAAGMLNKRCRHGAASLGSKMFVCGGYDG-SGFLSIAEMYSSVADQWCLIVPMHTRRSRV 517
Query: 382 GSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPL 430
LY VGG+ + +L VE YDP + WT +AP+
Sbjct: 518 SLVASCGRLYAVGGYDGQS---------NLSSVEMYDPETDCWTFMAPM 557
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 231 bits (589), Expect = 1e-60
Identities = 152/521 (29%), Positives = 256/521 (49%), Gaps = 30/521 (5%)
Query: 61 RAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESL 120
R VL++ S YF AMF+ ++E++ E+ + + P L L+ YAY+ R+ + E+N E L
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEG-VEPNSLWSLIQYAYTGRLELKEDNIECL 232
Query: 121 LEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIR 180
L +L+ + +AC +FL K LHP+NCLG+ +DA CT L++++ + +F +
Sbjct: 233 LSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVI 292
Query: 181 KNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLAL 240
+N++F+ LP + +LL+S+++ +E + + + W+ +DL++R L +LL +RL L
Sbjct: 293 RNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPL 352
Query: 241 LPAIYL--MENVAMEELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRK-TGHAL 297
L +L MEN L + ++++ EA++ L + + ++ S +PRK T L
Sbjct: 353 LAPQFLADMEN---NVLFRDDIECQKLIMEAMKYHL-LPERRPMLQSPRTKPRKSTVGTL 408
Query: 298 FLLGG--QTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVS 355
F +GG T + D + P A++ R +F + K+Y+ GGR ++
Sbjct: 409 FAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLN 468
Query: 356 KDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVE 415
V Y+ + WS PM R G G A L+ +Y VGGH + L VE
Sbjct: 469 -TVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS---------YLNTVE 518
Query: 416 HYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVP 475
+DP +W VA + S V KL+A GG S L V+C+D N+WT+
Sbjct: 519 RWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGS-SCLKSVECFDPHTNKWTLC 577
Query: 476 ATCPQPWRYTAAAVLGNQIFIMGG--------DTEFSACSAYKFNSETYQWTKVGDVTAK 527
A + ++ +GG + S C +++ +T WT V ++
Sbjct: 578 AQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDC-VERYDPKTDMWTAVASMSIS 636
Query: 528 RMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSI 568
R + G+KLY VGGY G T++ YDP + W +
Sbjct: 637 RDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQV 677
Score = 55.5 bits (132), Expect = 1e-07
Identities = 49/175 (28%), Positives = 66/175 (37%), Gaps = 45/175 (25%)
Query: 314 DQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAP 373
D +A++ A + +PR + K+Y GGR + + K V +D +W+ A
Sbjct: 521 DPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCL-KSVECFDPHTNKWTLCAQ 579
Query: 374 MLVARFGHGSAELKHCLYVVGGHTAATGCLP--------------------ASPSVS--- 410
M R G G LY +GGH A L AS S+S
Sbjct: 580 MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDA 639
Query: 411 ---------------------LKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKL 444
L VE YDP N+WT VAPL G + A VV+ KL
Sbjct: 640 VGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 694
Score = 51.6 bits (122), Expect = 2e-06
Identities = 36/140 (25%), Positives = 61/140 (43%), Gaps = 4/140 (2%)
Query: 446 LFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSA 505
LFA GG S ++ YD N WT A AVL ++++++GG
Sbjct: 408 LFAVGGMD-STKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKT 466
Query: 506 CSAYK-FNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDV 564
+ + +N +T W+ + ++ R +Y VGG+ G T++ +DP
Sbjct: 467 LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQ 526
Query: 565 WNSITTV--PYSLIPTAFVS 582
WN + T+ P S + A +S
Sbjct: 527 WNFVATMSTPRSTVGVAVLS 546
>gi|128485503 kelch-like 30 [Homo sapiens]
Length = 560
Score = 229 bits (583), Expect = 7e-60
Identities = 164/580 (28%), Positives = 268/580 (46%), Gaps = 57/580 (9%)
Query: 32 VLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDN 91
+L L LR Q DV L G R PCHR +LA S YF AMF+G ES + V
Sbjct: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVEL-R 59
Query: 92 SIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLG 151
+ P V+ L+D+ Y+ R+ I + N E+L L F ++ C +L++ L NCLG
Sbjct: 60 DVEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLG 119
Query: 152 MLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVY 211
+ + + +W NF+ + + ++FLQLP++ +V L+ + L+ + E+
Sbjct: 120 ICEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRL 179
Query: 212 ESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIR 271
E+ + W+ +D + R +LPELL V L +P + + +A E LI +E+
Sbjct: 180 EALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLI----------QESEA 229
Query: 272 CKLKILQ-NDGVVTSLCARPRKTGHALFLLGGQTFMCDK-----------LYLVDQKAKE 319
C+ + Q +DG +L +K L ++GGQ ++ + KAK
Sbjct: 230 CRAALSQGHDGAPLAL---QQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKR 286
Query: 320 IIPKADIPSPRK-EFSACAIGCKVYITGG-RGSENGV--SKDVWVYDTLHEEWSKAAPML 375
+ D P K FS A+ +Y+TGG RG++ + W + W APML
Sbjct: 287 WMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPML 346
Query: 376 VARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVS 435
R H SA L +YV+GG T + + +VE YDP + WT V+P + VS
Sbjct: 347 KPRTNHASAALNGEIYVIGGTT-----------LDVVEVESYDPYTDSWTPVSPALKYVS 395
Query: 436 NAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPAT--CPQPWRYTAAAVLGNQ 493
N + + +L+ G ++ ++ L +QCY+ + W+V A+ P+ A L +
Sbjct: 396 NFSAAGCRGRLYLVGSSACKYNAL-ALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGE 454
Query: 494 IFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGG-YFGIQ-- 550
++++G +T+ Y ++ W KV + + V G+ LYV GG + G++
Sbjct: 455 LYLIGDNTK----KVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGD 510
Query: 551 RCKTLDCYDPTLDVWNSITTVP----YSLIPTAF--VSTW 584
++ YD D W +P Y T F VS W
Sbjct: 511 YHVEMEAYDTVRDTWTRHGALPRLWLYHGASTVFLDVSKW 550
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 224 bits (570), Expect = 2e-58
Identities = 153/543 (28%), Positives = 266/543 (48%), Gaps = 25/543 (4%)
Query: 39 LRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVL 98
L+QQ+L DV+L GNR P HR VL++ S YF AMF+ + E++ E+ + I P L
Sbjct: 206 LKQQQL-CDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEG-IDPNAL 263
Query: 99 ELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDA 158
L+ +AY+ + + E+ E+LL A +L+ + + C FL K LHP+NCLG+ +DA
Sbjct: 264 WDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADA 323
Query: 159 HQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWI 218
C +L +++ + N + +N++FL LP + + +LL+S+++ DE ++ + + W+
Sbjct: 324 QGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWV 383
Query: 219 SYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKILQ 278
YD++ R L LL +RL LLP ++ ++ L + ++++ EA++ L + +
Sbjct: 384 KYDMQSRCNDLSMLLAFIRLPLLPP-QILADLENHALFKNDLECQKLILEAMKYHL-LPE 441
Query: 279 NDGVVTSLCARPRK-TGHALFLLGG--QTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSA 335
++ S +PRK T L+ +GG + D + I + R +F
Sbjct: 442 RRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGV 501
Query: 336 CAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGG 395
I K+++ GGR ++ V Y+ + W+ PM R G G L+ +Y VGG
Sbjct: 502 AVIDDKLFVIGGRDGLKTLN-TVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGG 560
Query: 396 HTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVS 455
H + L VE +DP +WT VA + S V + KL++ GG S
Sbjct: 561 HDGWS---------YLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGS 611
Query: 456 HDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSA--CS-----A 508
L ++ YD N+W + A + A ++ +GG ++ CS
Sbjct: 612 -SCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYV 670
Query: 509 YKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSI 568
+++ +T WT V ++ R + G++LY VGGY G T++ YDP + W +
Sbjct: 671 ERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQM 730
Query: 569 TTV 571
++
Sbjct: 731 ASL 733
Score = 47.4 bits (111), Expect = 4e-05
Identities = 29/83 (34%), Positives = 38/83 (45%), Gaps = 9/83 (10%)
Query: 361 YDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPT 420
YD + W+ AP+ + R G L LY VGG+ T L +E YDP
Sbjct: 673 YDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQT---------YLNTMESYDPQ 723
Query: 421 INKWTMVAPLREGVSNAAVVSAK 443
N+WT +A L G + A VV K
Sbjct: 724 TNEWTQMASLNIGRAGACVVVIK 746
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 216 bits (551), Expect = 4e-56
Identities = 146/479 (30%), Positives = 227/479 (47%), Gaps = 16/479 (3%)
Query: 98 LELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSD 157
L +L+DY Y++ + + EEN + LL A +L+ QD++ C EFLE LHP NCLG+ +D
Sbjct: 19 LRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFAD 78
Query: 158 AHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINW 217
H CT L + +F + +E+FL L + V L+SS++L E V+E+ I W
Sbjct: 79 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAW 138
Query: 218 ISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKIL 277
+++D R ++ L++ VRL LLP YL++ V E L+ K+ + EA++ L
Sbjct: 139 VNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPT 198
Query: 278 QNDGVVTSLCAR---PRKTGHALFLLGGQTFMCDK-LYLVDQKAKEIIPKADIPSPRKEF 333
+ ++ S+ R P + ++GGQ + + D K + A++PS R
Sbjct: 199 EQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRA 258
Query: 334 SACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVV 393
+ V+ GG V + V YD + ++W+ A M R G+A L LY V
Sbjct: 259 GMVYMAGLVFAVGGFNGSLRV-RTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAV 317
Query: 394 GGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGG-T 452
GG +TG L VE Y+ N+W VAP+ S+ V L+A GG
Sbjct: 318 GGFDGSTG---------LSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYD 368
Query: 453 SVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG-DTEFSACSAYKF 511
S L V+CY+ N WT A VL N ++ +GG D S +
Sbjct: 369 GASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVY 428
Query: 512 NSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITT 570
+ T W +V D+ R + A LYVVGG G +++ Y+PT D W +++
Sbjct: 429 DPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSS 487
Score = 70.5 bits (171), Expect = 4e-12
Identities = 54/176 (30%), Positives = 74/176 (42%), Gaps = 11/176 (6%)
Query: 316 KAKEIIPKADIPSPRKEFSACAIGCKVYITGGR-GSENGVSKDVWVYDTLHEEWSKAAPM 374
K+ E A + + R +G +Y GG G+ V Y+ EW+ A M
Sbjct: 335 KSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM 394
Query: 375 LVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGV 434
R G G L + LY VGGH P V K VE YDPT N W VA +
Sbjct: 395 STRRSGAGVGVLNNLLYAVGGHDG--------PLVR-KSVEVYDPTTNAWRQVADMNMCR 445
Query: 435 SNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVL 490
NA V + L+ GG S + L V+ Y+ ++WTV ++C R A +
Sbjct: 446 RNAGVCAVNGLLYVVGGDDGSCN-LASVEYYNPTTDKWTVVSSCMSTGRSYAGVTV 500
Score = 45.8 bits (107), Expect = 1e-04
Identities = 20/76 (26%), Positives = 39/76 (51%)
Query: 496 IMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTL 555
++GG + S ++ + +W +V ++ ++R V ++ VGG+ G R +T+
Sbjct: 223 VVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTV 282
Query: 556 DCYDPTLDVWNSITTV 571
D YDP D W S+ +
Sbjct: 283 DSYDPVKDQWTSVANM 298
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 214 bits (545), Expect = 2e-55
Identities = 150/545 (27%), Positives = 252/545 (46%), Gaps = 27/545 (4%)
Query: 36 LNLLRQQRLFTDVLLH-----AGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFD 90
+N LR + DV L A F H+ VLA+ S F+AMF+ GL+E Q EV
Sbjct: 67 MNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLRE-QGMEVVSI 125
Query: 91 NSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCL 150
IHP+V+E L+++AY++ + + E+ ++ M + + AC++FL + L P+N +
Sbjct: 126 EGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Query: 151 GMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLV 210
G+ ++ C +L++ + +F + K E+F L +V L+S ++L E V
Sbjct: 186 GIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEV 245
Query: 211 YESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAI 270
+ + INW+ YD ++R Y+ LL+ VR L +L + E++ + K+ + +
Sbjct: 246 FHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYL---V 302
Query: 271 RCKLKILQNDGVVTSLCARPRKTGHALFLLGGQTFMCDKLYLVDQKAKE--IIPKADIPS 328
+ ++ + C P K G ++ GG F YL + + AD+
Sbjct: 303 KIFEELTLHKPTQVMPCRAP-KVGRLIYTAGGY-FRQSLSYLEAYNPSDGTWLRLADLQV 360
Query: 329 PRKEFSACAIGCKVYITGGRGSE---NGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAE 385
PR + C +G +Y GGR + N S + Y+ + +WS APM V R G
Sbjct: 361 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV 420
Query: 386 LKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLK 445
+ +Y VGG + GC + VE Y+P ++W +VAP+ V
Sbjct: 421 IDGHIYAVGG---SHGC------IHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
Query: 446 LFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG-DTEFS 504
L+A GG ++L +CY N W + VL N I+ GG D +
Sbjct: 472 LYAVGGFD-GTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQ 530
Query: 505 ACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDV 564
S +++ ET WT V + +R + ++YV+GGY G +++CYDP D
Sbjct: 531 LNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDT 590
Query: 565 WNSIT 569
W+ +T
Sbjct: 591 WSEVT 595
Score = 66.6 bits (161), Expect = 6e-11
Identities = 45/169 (26%), Positives = 70/169 (41%), Gaps = 10/169 (5%)
Query: 410 SLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHD---KLPKVQCYD 466
SL +E Y+P+ W +A L+ S A L+A GG + S D + CY+
Sbjct: 338 SLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYN 397
Query: 467 QCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSAC----SAYKFNSETYQWTKVG 522
N+W+ A P V+ I+ +GG C S ++ E +W V
Sbjct: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGS---HGCIHHNSVERYEPERDEWHLVA 454
Query: 523 DVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTV 571
+ +R+ LY VGG+ G R + +CY P + W IT +
Sbjct: 455 PMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAM 503
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/110 (28%), Positives = 45/110 (40%), Gaps = 10/110 (9%)
Query: 330 RKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHC 389
R C + +Y GG ++ ++ V YD E W+ APM R G +
Sbjct: 507 RSGAGVCVLHNCIYAAGGYDGQDQLNS-VERYDVETETWTFVAPMKHRRSALGITVHQGR 565
Query: 390 LYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAV 439
+YV+GG+ T L VE YDP + W+ V + G S V
Sbjct: 566 IYVLGGYDGHT---------FLDSVECYDPDTDTWSEVTRMTSGRSGVGV 606
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 214 bits (545), Expect = 2e-55
Identities = 150/545 (27%), Positives = 252/545 (46%), Gaps = 27/545 (4%)
Query: 36 LNLLRQQRLFTDVLLH-----AGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFD 90
+N LR + DV L A F H+ VLA+ S F+AMF+ GL+E Q EV
Sbjct: 67 MNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLRE-QGMEVVSI 125
Query: 91 NSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCL 150
IHP+V+E L+++AY++ + + E+ ++ M + + AC++FL + L P+N +
Sbjct: 126 EGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Query: 151 GMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLV 210
G+ ++ C +L++ + +F + K E+F L +V L+S ++L E V
Sbjct: 186 GIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEV 245
Query: 211 YESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAI 270
+ + INW+ YD ++R Y+ LL+ VR L +L + E++ + K+ + +
Sbjct: 246 FHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYL---V 302
Query: 271 RCKLKILQNDGVVTSLCARPRKTGHALFLLGGQTFMCDKLYLVDQKAKE--IIPKADIPS 328
+ ++ + C P K G ++ GG F YL + + AD+
Sbjct: 303 KIFEELTLHKPTQVMPCRAP-KVGRLIYTAGGY-FRQSLSYLEAYNPSDGTWLRLADLQV 360
Query: 329 PRKEFSACAIGCKVYITGGRGSE---NGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAE 385
PR + C +G +Y GGR + N S + Y+ + +WS APM V R G
Sbjct: 361 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV 420
Query: 386 LKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLK 445
+ +Y VGG + GC + VE Y+P ++W +VAP+ V
Sbjct: 421 IDGHIYAVGG---SHGC------IHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
Query: 446 LFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG-DTEFS 504
L+A GG ++L +CY N W + VL N I+ GG D +
Sbjct: 472 LYAVGGFD-GTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQ 530
Query: 505 ACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDV 564
S +++ ET WT V + +R + ++YV+GGY G +++CYDP D
Sbjct: 531 LNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDT 590
Query: 565 WNSIT 569
W+ +T
Sbjct: 591 WSEVT 595
Score = 66.6 bits (161), Expect = 6e-11
Identities = 45/169 (26%), Positives = 70/169 (41%), Gaps = 10/169 (5%)
Query: 410 SLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHD---KLPKVQCYD 466
SL +E Y+P+ W +A L+ S A L+A GG + S D + CY+
Sbjct: 338 SLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYN 397
Query: 467 QCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSAC----SAYKFNSETYQWTKVG 522
N+W+ A P V+ I+ +GG C S ++ E +W V
Sbjct: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGS---HGCIHHNSVERYEPERDEWHLVA 454
Query: 523 DVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTV 571
+ +R+ LY VGG+ G R + +CY P + W IT +
Sbjct: 455 PMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAM 503
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/110 (28%), Positives = 45/110 (40%), Gaps = 10/110 (9%)
Query: 330 RKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHC 389
R C + +Y GG ++ ++ V YD E W+ APM R G +
Sbjct: 507 RSGAGVCVLHNCIYAAGGYDGQDQLNS-VERYDVETETWTFVAPMKHRRSALGITVHQGR 565
Query: 390 LYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAV 439
+YV+GG+ T L VE YDP + W+ V + G S V
Sbjct: 566 IYVLGGYDGHT---------FLDSVECYDPDTDTWSEVTRMTSGRSGVGV 606
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 214 bits (544), Expect = 2e-55
Identities = 150/539 (27%), Positives = 255/539 (47%), Gaps = 24/539 (4%)
Query: 37 NLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPE 96
N LR + DV++ F H+ +L +CS YF A+F+ G ++ N I P+
Sbjct: 30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPG-ISPD 88
Query: 97 VLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLS 156
+++L+++YAY+ V I +N E LL A D I C EFL+ L NC+G+ +
Sbjct: 89 MMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFT 148
Query: 157 DAHQCTKLYELSWRMCLSNF-QTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAI 215
D + C +L + ++ L NF + ++ + +FL+L + ++ +EL + E V+E+ +
Sbjct: 149 DYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAIL 208
Query: 216 NWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLK 275
WIS+D + R ++ LL VRLAL+ A Y M NV M + + + K ++ A++
Sbjct: 209 KWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYD 268
Query: 276 ILQN---DGVVTSLCARPRKTGHALFLLGGQT--FMCDKLYLVDQKA-KEIIPKADIPSP 329
+ N + T+ RPR LF +GG + + + D +A + + + SP
Sbjct: 269 LNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESP 328
Query: 330 RKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHC 389
R A + VYI GG S + V +D + + W + APM R L +
Sbjct: 329 RAYHGAAYLKGYVYIIGGFDSVD-YFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNF 387
Query: 390 LYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAF 449
+Y +GG V L E Y+P N+WT++AP+ E S+A+ + K++
Sbjct: 388 IYAMGGFDG---------YVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYIC 438
Query: 450 GGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVL--GNQIFIMGG-DTEFSAC 506
GG + ++ L + Y+ N+WTV A P R + V+ G ++ +GG D
Sbjct: 439 GGFN-GNECLFTAEVYNTESNQWTVIA--PMRSRRSGIGVIAYGEHVYAVGGFDGANRLR 495
Query: 507 SAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVW 565
SA ++ W + + R + + L+VVGG+ G ++CYD D W
Sbjct: 496 SAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEW 554
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 210 bits (535), Expect = 3e-54
Identities = 148/540 (27%), Positives = 239/540 (44%), Gaps = 59/540 (10%)
Query: 36 LNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHP 95
+N +R+Q+ DV+L R P HR VLAA S +F MF+ + ES+ EV ++ P
Sbjct: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDA-EP 92
Query: 96 EVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLL 155
+++E L+++AY++R+ +N N +SLL+A + + + ++ C +FL++ + +NCLG+ +L
Sbjct: 93 DIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVL 152
Query: 156 SDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAI 215
++ C +L + +F + K ++FLQL V LL+ + L E VY++A+
Sbjct: 153 AECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAV 212
Query: 216 NWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLK 275
W+ YD R ++ ++L VR L+ +L + V E LI + ++V +R L
Sbjct: 213 RWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHL- 271
Query: 276 ILQNDGVVTSLCARPRKTGH---------------------------------------- 295
+ D RPR+ H
Sbjct: 272 LSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAAC 331
Query: 296 -----ALFLLGG-QTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRG 349
+++LGG Q F ++ + K P+PR +ACA K+Y +GG
Sbjct: 332 VFWDNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSE 391
Query: 350 SENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSV 409
N YDT E W ML R HG E +YV GG S V
Sbjct: 392 VGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNN----VSGRV 447
Query: 410 SLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCE 469
L E YDP WT + P+ E N +V K K+FA GG + L V+ YD
Sbjct: 448 -LNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQN-GLGGLDNVEYYDIKL 505
Query: 470 NRWTVPATCPQPWR--YTAAAVLGNQIFIMGGDTEFSACS-AYKFNSETYQWTKVGDVTA 526
N W + P PW+ A +G+ ++++ G ++N+ET +W V A
Sbjct: 506 NEWKM--VSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRA 563
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 209 bits (531), Expect = 7e-54
Identities = 159/576 (27%), Positives = 252/576 (43%), Gaps = 50/576 (8%)
Query: 23 FHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKES 82
F +A +L +N +R + F DV L G +F HR VLAA S YF A+F+GG+KES
Sbjct: 14 FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKES 73
Query: 83 QDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEK 142
V I + ++LLD+ Y+ V I N + L+ A DML+ ++ C EFL+
Sbjct: 74 SKDVVPI-LGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKG 132
Query: 143 NLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEEL 202
+ P NC+G+ S+ C L E S +F + E+FL L +D ++++L SEEL
Sbjct: 133 QIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEEL 192
Query: 203 ETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLME----------NVAM 252
EDE V+ +A+ WI DL KR ++ E+L +R LLP L++ VA+
Sbjct: 193 SIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVAL 252
Query: 253 EELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHA-LFLLGGQTFMCDKLY 311
+ L+ + + + +E C LQ V RPRK L+ +GG T + +
Sbjct: 253 QTLLKEYCEVCKSPKENKFC--SFLQTSKV------RPRKKARKYLYAVGGYTRLQGGRW 304
Query: 312 LVDQKAKEIIPKAD-----------IPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWV 360
D +A + + D + R +G VY GG ++ +
Sbjct: 305 -SDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE-KDSMIFDCTEC 362
Query: 361 YDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPT 420
YD + ++W+ A M R G G +Y +GG A +E +DP
Sbjct: 363 YDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAE---------IGNTIERFDPD 413
Query: 421 INKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQ 480
NKW +V + + ++ GG S +L + YD RW+
Sbjct: 414 ENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGT 473
Query: 481 PWRYTAAAVLGNQIFIMGG--DTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGN 538
Y A L + I+ +GG +T+ + + K++ E +W +V + R VA
Sbjct: 474 RRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNG 533
Query: 539 KLYVVGG------YFGIQRCKTLDCYDPTLDVWNSI 568
LYV GG + +++ Y+P D W I
Sbjct: 534 LLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEI 569
Score = 47.0 bits (110), Expect = 5e-05
Identities = 30/128 (23%), Positives = 51/128 (39%), Gaps = 5/128 (3%)
Query: 450 GGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTE---FSAC 506
GG L V+ +D WT ++ Q VLG ++ +GG+ + F
Sbjct: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT 360
Query: 507 SAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWN 566
Y + T QWT V + R +Y +GG+ G + T++ +DP + W
Sbjct: 361 ECY--DPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWE 418
Query: 567 SITTVPYS 574
+ + S
Sbjct: 419 VVGNMAVS 426
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,678,832
Number of Sequences: 37866
Number of extensions: 1012219
Number of successful extensions: 3529
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 170
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 2130
Number of HSP's gapped (non-prelim): 429
length of query: 589
length of database: 18,247,518
effective HSP length: 108
effective length of query: 481
effective length of database: 14,157,990
effective search space: 6809993190
effective search space used: 6809993190
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.