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Search of human proteins with 4504217
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504217 guanylate cyclase 2D, membrane (retina-specific)
[Homo sapiens]
(1103 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom... 2211 0.0
gi|134152694 guanylate cyclase 2F [Homo sapiens] 1055 0.0
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] 496 e-140
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens] 485 e-137
gi|222080083 guanylate cyclase 2C [Homo sapiens] 416 e-116
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho... 166 9e-41
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 166 9e-41
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 166 9e-41
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom... 166 9e-41
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 166 9e-41
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens] 164 3e-40
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho... 162 2e-39
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens] 160 6e-39
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens] 119 2e-26
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens] 119 2e-26
gi|34486092 adenylate cyclase 5 [Homo sapiens] 116 1e-25
gi|31083193 adenylate cyclase 1 [Homo sapiens] 111 3e-24
gi|4557257 adenylate cyclase 8 [Homo sapiens] 110 1e-23
gi|4557255 adenylate cyclase 7 [Homo sapiens] 110 1e-23
gi|115387102 adenylate cyclase 2 [Homo sapiens] 107 5e-23
gi|24497587 adenylate cyclase 4 [Homo sapiens] 107 8e-23
gi|50959205 adenylate cyclase 9 [Homo sapiens] 99 2e-20
gi|148536830 adenylate cyclase 3 [Homo sapiens] 99 3e-20
gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinas... 90 1e-17
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 82 3e-15
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 82 3e-15
gi|187475373 c-src tyrosine kinase [Homo sapiens] 78 4e-14
gi|4758078 c-src tyrosine kinase [Homo sapiens] 78 4e-14
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 78 4e-14
gi|66932999 testis-specific protein kinase 1 [Homo sapiens] 78 4e-14
>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
sapiens]
Length = 1103
Score = 2211 bits (5730), Expect = 0.0
Identities = 1103/1103 (100%), Positives = 1103/1103 (100%)
Query: 1 MTACARRAGGLPDPGLCGPAWWAPSLPRLPRALPRLPLLLLLLLLQPPALSAVFTVGVLG 60
MTACARRAGGLPDPGLCGPAWWAPSLPRLPRALPRLPLLLLLLLLQPPALSAVFTVGVLG
Sbjct: 1 MTACARRAGGLPDPGLCGPAWWAPSLPRLPRALPRLPLLLLLLLLQPPALSAVFTVGVLG 60
Query: 61 PWACDPIFSRARPDLAARLAAARLNRDPGLAGGPRFEVALLPEPCRTPGSLGAVSSALAR 120
PWACDPIFSRARPDLAARLAAARLNRDPGLAGGPRFEVALLPEPCRTPGSLGAVSSALAR
Sbjct: 61 PWACDPIFSRARPDLAARLAAARLNRDPGLAGGPRFEVALLPEPCRTPGSLGAVSSALAR 120
Query: 121 VSGLVGPVNPAACRPAELLAEEAGIALVPWGCPWTQAEGTTAPAVTPAADALYALLRAFG 180
VSGLVGPVNPAACRPAELLAEEAGIALVPWGCPWTQAEGTTAPAVTPAADALYALLRAFG
Sbjct: 121 VSGLVGPVNPAACRPAELLAEEAGIALVPWGCPWTQAEGTTAPAVTPAADALYALLRAFG 180
Query: 181 WARVALVTAPQDLWVEAGRSLSTALRARGLPVASVTSMEPLDLSGAREALRKVRDGPRVT 240
WARVALVTAPQDLWVEAGRSLSTALRARGLPVASVTSMEPLDLSGAREALRKVRDGPRVT
Sbjct: 181 WARVALVTAPQDLWVEAGRSLSTALRARGLPVASVTSMEPLDLSGAREALRKVRDGPRVT 240
Query: 241 AVIMVMHSVLLGGEEQRYLLEAAEELGLTDGSLVFLPFDTIHYALSPGPEALAALANSSQ 300
AVIMVMHSVLLGGEEQRYLLEAAEELGLTDGSLVFLPFDTIHYALSPGPEALAALANSSQ
Sbjct: 241 AVIMVMHSVLLGGEEQRYLLEAAEELGLTDGSLVFLPFDTIHYALSPGPEALAALANSSQ 300
Query: 301 LRRAHDAVLTLTRHCPSEGSVLDSLRRAQERRELPSDLNLQQVSPLFGTIYDAVFLLARG 360
LRRAHDAVLTLTRHCPSEGSVLDSLRRAQERRELPSDLNLQQVSPLFGTIYDAVFLLARG
Sbjct: 301 LRRAHDAVLTLTRHCPSEGSVLDSLRRAQERRELPSDLNLQQVSPLFGTIYDAVFLLARG 360
Query: 361 VAEARAAAGGRWVSGAAVARHIRDAQVPGFCGDLGGDEEPPFVLLDTDAAGDRLFATYML 420
VAEARAAAGGRWVSGAAVARHIRDAQVPGFCGDLGGDEEPPFVLLDTDAAGDRLFATYML
Sbjct: 361 VAEARAAAGGRWVSGAAVARHIRDAQVPGFCGDLGGDEEPPFVLLDTDAAGDRLFATYML 420
Query: 421 DPARGSFLSAGTRMHFPRGGSAPGPDPSCWFDPNNICGGGLEPGLVFLGFLLVVGMGLAG 480
DPARGSFLSAGTRMHFPRGGSAPGPDPSCWFDPNNICGGGLEPGLVFLGFLLVVGMGLAG
Sbjct: 421 DPARGSFLSAGTRMHFPRGGSAPGPDPSCWFDPNNICGGGLEPGLVFLGFLLVVGMGLAG 480
Query: 481 AFLAHYVRHRLLHMQMVSGPNKIILTVDDITFLHPHGGTSRKVAQGSRSSLGARSMSDIR 540
AFLAHYVRHRLLHMQMVSGPNKIILTVDDITFLHPHGGTSRKVAQGSRSSLGARSMSDIR
Sbjct: 481 AFLAHYVRHRLLHMQMVSGPNKIILTVDDITFLHPHGGTSRKVAQGSRSSLGARSMSDIR 540
Query: 541 SGPSQHLDSPNIGVYEGDRVWLKKFPGDQHIAIRPATKTAFSKLQELRHENVALYLGLFL 600
SGPSQHLDSPNIGVYEGDRVWLKKFPGDQHIAIRPATKTAFSKLQELRHENVALYLGLFL
Sbjct: 541 SGPSQHLDSPNIGVYEGDRVWLKKFPGDQHIAIRPATKTAFSKLQELRHENVALYLGLFL 600
Query: 601 ARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHR 660
ARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHR
Sbjct: 601 ARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHR 660
Query: 661 GVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALE 720
GVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALE
Sbjct: 661 GVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALE 720
Query: 721 RRGTLAGDVFSLAIIMQEVVCRSAPYAMLELTPEEVVQRVRSPPPLCRPLVSMDQAPVEC 780
RRGTLAGDVFSLAIIMQEVVCRSAPYAMLELTPEEVVQRVRSPPPLCRPLVSMDQAPVEC
Sbjct: 721 RRGTLAGDVFSLAIIMQEVVCRSAPYAMLELTPEEVVQRVRSPPPLCRPLVSMDQAPVEC 780
Query: 781 ILLMKQCWAEQPELRPSMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTE 840
ILLMKQCWAEQPELRPSMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTE
Sbjct: 781 ILLMKQCWAEQPELRPSMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTE 840
Query: 841 ELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIE 900
ELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIE
Sbjct: 841 ELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIE 900
Query: 901 VVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAV 960
VVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAV
Sbjct: 901 VVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAV 960
Query: 961 GTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHV 1020
GTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHV
Sbjct: 961 GTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHV 1020
Query: 1021 NLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRRGFNKPIPKPPDLQPGSSNHG 1080
NLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRRGFNKPIPKPPDLQPGSSNHG
Sbjct: 1021 NLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRRGFNKPIPKPPDLQPGSSNHG 1080
Query: 1081 ISLQEIPPERRRKLEKARPGQFS 1103
ISLQEIPPERRRKLEKARPGQFS
Sbjct: 1081 ISLQEIPPERRRKLEKARPGQFS 1103
>gi|134152694 guanylate cyclase 2F [Homo sapiens]
Length = 1108
Score = 1055 bits (2729), Expect = 0.0
Identities = 557/1084 (51%), Positives = 724/1084 (66%), Gaps = 46/1084 (4%)
Query: 39 LLLLLLLQPPALSAVFTVGVLGPWACDPIFSRARPDLAARLAAARLNRDPGLAGGPRFEV 98
LL ++ L + + +GV+GPWACD +FS+A P++AARLA R+NRDP FE
Sbjct: 38 LLSVMSLPQQVWTLPYKIGVVGPWACDSLFSKALPEVAARLAIERINRDPSFDLSYSFEY 97
Query: 99 ALLPEPCRTPGSLGAVSSALARVSGLVGPVNPAACRPAELLAEEAGIALVPWGCPWTQAE 158
+L E C+T +L + S SG +GP NP C A LL + W C + +
Sbjct: 98 VILNEDCQTSRALSSFISHHQMASGFIGPTNPGYCEAASLLGNSWDKGIFSWACVNYELD 157
Query: 159 G-----TTAPAVTPAADALYALLRAFGWARVALVTAPQDLWVEAGRSLSTALRARGLPVA 213
T + + L +++ F WA ++++ +D+WV +++ALR+ GLPV
Sbjct: 158 NKISYPTFSRTLPSPIRVLVTVMKYFQWAHAGVISSDEDIWVHTANRVASALRSHGLPVG 217
Query: 214 SVTSMEPLDLSGAREALRKVRDGPRVTAVIMVMHSVLLGGEEQRYLLEAAEELGLTDGSL 273
V + D R+AL+++ R+ +IM MHS L+GGE Q +LLE A +L +TDG+
Sbjct: 218 VVLTTGQ-DSQSMRKALQRIHQADRIRIIIMCMHSALIGGETQMHLLECAHDLKMTDGTY 276
Query: 274 VFLPFDTIHYALSPGPEALAALANSSQLRRAHDAVLTLTRHCPSEGSVLDSLRRAQERRE 333
VF+P+D + Y+L L N+ +LR A+DAVLT+T E + + A R E
Sbjct: 277 VFVPYDALLYSLPYKHTPYRVLRNNPKLREAYDAVLTITVES-QEKTFYQAFTEAAARGE 335
Query: 334 LPSDLNLQQVSPLFGTIYDAVFLLARGVAEARAAAGGRWVSGAAVARHIRDAQVPGFCG- 392
+P L QVSPLFGTIY++++ +A+ + A G A++ +H R+ Q GF
Sbjct: 336 IPEKLEFDQVSPLFGTIYNSIYFIAQAMNNAMKENGQ--AGAASLVQHSRNMQFHGFNQL 393
Query: 393 ---DLGGDEEPPFVLLDTDAAGDRLFATYMLDPARGSFLSAGTRMHFPRGGSAPGPDPSC 449
D G+ +V+LDT+ L +TY +D GT +HFP GG P D C
Sbjct: 394 MRTDSNGNGISEYVILDTNLKEWELHSTYTVDMEMELLRFGGTPIHFP-GGRPPRADAKC 452
Query: 450 WFDPNNICGGGLEPGLVFLGFLLVVGMGLAGAFLAHYVRHRLLHMQMVSGPNKIILTVDD 509
WF IC GG++P + L ++ L+ A+++R R+ +Q++ GPN+I+LT++D
Sbjct: 453 WFAEGKICHGGIDPAFAMMVCLTLLIALLSINGFAYFIRRRINKIQLIKGPNRILLTLED 512
Query: 510 ITFLHPHGGTSRKVAQGSRSSLGARSMSDIRSGPSQHL------------DSPNIGVYEG 557
+TF++PH G+ R GSR+S+ + S+++SG S L ++ NI +YEG
Sbjct: 513 VTFINPHFGSKR----GSRASVSFQITSEVQSGRSPRLSFSSGSLTPATYENSNIAIYEG 568
Query: 558 DRVWLKKFP----GDQHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEG 613
D VWLKKF GD +I+ F +++LRHEN+ LG F G
Sbjct: 569 DWVWLKKFSLGDFGDLK-SIKSRASDVFEMMKDLRHENINPLLGFFYDSGM--------- 618
Query: 614 NLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCI 673
A+V+E C+RGSL+D+L +++KLDWMFKSSLLLDLIKG++YLHHR HGRLKSRNC+
Sbjct: 619 -FAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCV 677
Query: 674 VDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALERRGTLAGDVFSLA 733
VDGRFVLK+TD+G +LE ++ E E+ LWTAPELLR P R G+ AGDV+S A
Sbjct: 678 VDGRFVLKVTDYGFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFA 737
Query: 734 IIMQEVVCRSAPYAMLELTPEEVVQRVRSPPPLCRPLVSMDQAPVECILLMKQCWAEQPE 793
IIMQEV+ R P+ M++L +E++ R++ PPP+ RP+V + AP EC+ LMKQCWAE E
Sbjct: 738 IIMQEVMVRGTPFCMMDLPAQEIINRLKKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAE 797
Query: 794 LRPSMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLL 853
RP+ D F+ FK NKG+KTNIIDSMLRMLEQYSSNLEDLIRERTEELE+EKQKT++LL
Sbjct: 798 QRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLL 857
Query: 854 TQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFD 913
TQMLPPSVAE+LK G VEPE F+ VTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFD
Sbjct: 858 TQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFD 917
Query: 914 AIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPV 973
AIIGSHDVYKVETIGDAYMVASGLP+RNG RHAAEIANMSLDILS+VGTF+MRHMPEVPV
Sbjct: 918 AIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPV 977
Query: 974 RIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDS 1033
RIRIGLHSGP VAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHV+LSTV IL+ L
Sbjct: 978 RIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSE 1037
Query: 1034 GYQVELRGRTELKGKGAEDTFWLVGRRGFNKPIPKPPDL-QPGSSNHGISLQEIPPERRR 1092
GY+VELRGRTELKGKG E+TFWL+G++GF KP+P PP + + G HG+ EI +RR
Sbjct: 1038 GYEVELRGRTELKGKGTEETFWLIGKKGFMKPLPVPPPVDKDGQVGHGLQPVEIAAFQRR 1097
Query: 1093 KLEK 1096
K E+
Sbjct: 1098 KAER 1101
>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
Length = 1061
Score = 496 bits (1276), Expect = e-140
Identities = 378/1089 (34%), Positives = 547/1089 (50%), Gaps = 97/1089 (8%)
Query: 34 PRLP----LLLLLLLLQPPAL-------SAVFTVGVLGPWACDPI-FSRARPDLAARLAA 81
PR P L LLLLLL PP L + TV V+ P A +S AR A LA
Sbjct: 4 PRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELAL 63
Query: 82 ARLNRDPGLAGGPRFEVALLPEPCRTPGSLGAVSSALARVSGL-----------VGPVNP 130
A++ P L G L + +LG S A ++ + +GP
Sbjct: 64 AQVKARPDLLPGWTVRTVL----GSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCV 119
Query: 131 AACRPAELLAEEAGIALVPWGCPW-------TQAEGTTA-PAVTPAADALYALLRAFGWA 182
A P + L+ G P A T A P+ D + AL R GW
Sbjct: 120 YAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWE 179
Query: 183 RVALV-----TAPQDLWVEAGRSLSTALRARGLPVASVTSMEPLDLSGAREALRKVRDGP 237
R AL+ ++ L +R R DLS LR + P
Sbjct: 180 RQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTM---P 236
Query: 238 RVTAVIMVMHSVLLGGEEQRYLLEAAEELGLTDGSLVFLPFDTIHYAL----SPGPEALA 293
R VI + S + R L+ A E GL VF D +L P P
Sbjct: 237 RKGRVIYICSS----PDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPW 292
Query: 294 ALANSSQL--RRAHDAVLTLTRHCPSEGSVLDSLRRAQERRELPSDLNLQQ--VSPLFGT 349
+ + R+A A +T P L+ L++ + + ++ V+ + +
Sbjct: 293 ERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPAS 352
Query: 350 IYDAVFLLARGVAEARAAAGGRWVSGAAVARHIRDAQVPGFCG----DLGGDEEPPFVLL 405
+D + L + V E A GG G + + + + G G D GD E F L
Sbjct: 353 FHDGLLLYIQAVTET-LAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLW 411
Query: 406 DTDAAGDRLFATYMLDPARGSFLS-AGTRMHFPRGGSAPGPD-PSCWFDPNN-ICGGGLE 462
D D + ++ +G ++++P G P PD P C FD + C +
Sbjct: 412 DMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLG--YPPPDIPKCGFDNEDPACN---Q 466
Query: 463 PGLVFLGFLLVVG-MGLAGAFLAHYVRHRLLHMQMVSGPNKIILTVDDITFLHPHGGTSR 521
L L L +VG + L G + + +R + ++ + +D+ P
Sbjct: 467 DHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDV---EPSSLERH 523
Query: 522 KVAQGSRSSLGAR--SMSDIRSGPSQHLDSPNIGVYEGDRVWLKKFPGDQHIAIRPATKT 579
+ GSR +L R + + + Q Y+G+ V +K+ + I +
Sbjct: 524 LRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRV-NRKRIELTRKVLF 582
Query: 580 AFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLD 639
++++++E++ ++G A N+ +++E+C RGSLQD+L I LD
Sbjct: 583 ELKHMRDVQNEHLTRFVG----------ACTDPPNICILTEYCPRGSLQDILENESITLD 632
Query: 640 WMFKSSLLLDLIKGIRYLHHRGV-AHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVL- 697
WMF+ SL D++KG+ +LH+ + +HG LKS NC+VDGRFVLKITD+G LE+ + L
Sbjct: 633 WMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYG----LESFRDLD 688
Query: 698 PEPPRA--EDQLWTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPYAM--LELTP 753
PE +LWTAPELLR + RG+ AGDV+S II+QE+ RS + + L+L+P
Sbjct: 689 PEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSP 748
Query: 754 EEVVQRV-RSPPPLCRPLVSMDQAPVECILLMKQCWAEQPELRPSMDHTFDLFKNINKGR 812
+E+++RV R P RP +++ E LLM++CWAE P+ RP + N+
Sbjct: 749 KEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNREN 808
Query: 813 KTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVE 872
+NI+D++L +EQY++NLE+L+ ERT+ EK+K + LL Q+LP SVAE LK G V+
Sbjct: 809 SSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQ 868
Query: 873 PEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYM 932
E F+ VT+YFSDIVGFT +SA S P++VV LLNDLYT FDA+I + DVYKVETIGDAYM
Sbjct: 869 AEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYM 928
Query: 933 VASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLT 992
V SGLP RNG+ HA E+A M+L +L AV +FR+RH P+ +R+RIG+H+GP AGVVGL
Sbjct: 929 VVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLK 988
Query: 993 MPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAED 1052
MPRYCLFGDTVNTASRMES G +IH++ T +L G+++ELRG E+KGKG
Sbjct: 989 MPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEF-GGFELELRGDVEMKGKGKVR 1047
Query: 1053 TFWLVGRRG 1061
T+WL+G RG
Sbjct: 1048 TYWLLGERG 1056
>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
Length = 1047
Score = 485 bits (1249), Expect = e-137
Identities = 336/937 (35%), Positives = 483/937 (51%), Gaps = 75/937 (8%)
Query: 161 TAPAVTPAADALYALLRAFGW-ARVALV-------TAPQDLWVEAGRSLSTALRARGLPV 212
T P+ + + L F W AR AL+ P +E + AL+ L V
Sbjct: 142 TGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEG---VFEALQGSNLSV 198
Query: 213 A-SVTSMEPLDLSGAREALRKVRDGPRVTAV---IMVMHSVLLGGEEQRYLLEAAEELGL 268
V + EP G +A +R R+ + + ++H +LL + + L
Sbjct: 199 QHQVYAREP---GGPEQATHFIRANGRIVYICGPLEMLHEILLQAQREN----------L 245
Query: 269 TDGSLVFLPFDTIHYALSPGPEALAALA--------NSSQLRRAHDAVLTLTRHCPSEGS 320
T+G VF D +L GP + LR A VL +T P
Sbjct: 246 TNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYREPPNPE 305
Query: 321 VLDSLRRA--QERRELPSDLNLQQVSPLFGTIYDAVFLLARGVAEARAAAGGRWVSGAAV 378
+ R + R + +L ++ + G YD + L A + E GG G +
Sbjct: 306 YQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNET-IQEGGTREDGLRI 364
Query: 379 ARHIRDAQVPGFCG----DLGGDEEPPFVLL---DTDAAGDRLFATYMLDPARGSFLSAG 431
++ + G G D D E FVL D D+ + A Y A G
Sbjct: 365 VEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHY--SGAEKQIWWTG 422
Query: 432 TRMHFPRGGSAPGPDPSCWFDPNNICGGGLEPGLVFLGFLLVVGMGLAGAFLAHYVRHRL 491
+ + +G + P +P C FD ++ L L +V +G F+ V L
Sbjct: 423 RPIPWVKG-APPSDNPPCAFDLDDPSCDKTP-----LSTLAIVALGTGITFIMFGVSSFL 476
Query: 492 LHMQMVSGPNKIILTVDDITFLHPHGGTSRKVAQGSRS----SLGARSMSDIRSGPSQHL 547
+ +++ ++ + I + G S + +G+ S SL S + + ++
Sbjct: 477 IFRKLML-EKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQ 535
Query: 548 DSPNIGVYEGDRVWLKKFPGDQHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGP 607
N G ++G+ V +K + I + +++++ ++ ++G
Sbjct: 536 IFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIG---------- 584
Query: 608 AALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRGVA-HGR 666
A + N+ +V+E+C RGSLQD+L I LDWMF+ SL+ DL+KG+ +LH+ ++ HG
Sbjct: 585 ACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGS 644
Query: 667 LKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALERRGTLA 726
LKS NC+VD RFVLKITD+G + +LWTAPELL L G
Sbjct: 645 LKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQK 704
Query: 727 GDVFSLAIIMQEVVCRSAPYAM--LELTPEEVVQRVRSPP-PLCRPLVSMDQAPVECILL 783
DV+S II+QE+ RS P+ + L+L+P+E+VQ+VR+ P RP + Q E +LL
Sbjct: 705 ADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLL 764
Query: 784 MKQCWAEQPELRPSMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELE 843
M++CWA+ P RP + NK T+I+D++L +EQY++NLE L+ ERT+
Sbjct: 765 MERCWAQDPAERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYL 824
Query: 844 LEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVD 903
EK+K + LL Q+LP SVAE LK G V+ E F+ VT+YFSDIVGFT +SA S P++VV
Sbjct: 825 EEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVT 884
Query: 904 LLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTF 963
LLNDLYT FDAII + DVYKVETIGDAYMV SGLP RNGQRHA EIA M+L +L AV +F
Sbjct: 885 LLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSF 944
Query: 964 RMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLS 1023
R+RH P +R+RIG+H+GP AGVVGL MPRYCLFGDTVNTASRMES G +IHV+ +
Sbjct: 945 RIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSST 1004
Query: 1024 TVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRR 1060
T L L +Q+ELRG E+KGKG T+WL+G R
Sbjct: 1005 TKDALDELGC-FQLELRGDVEMKGKGKMRTYWLLGER 1040
>gi|222080083 guanylate cyclase 2C [Homo sapiens]
Length = 1073
Score = 416 bits (1068), Expect = e-116
Identities = 228/472 (48%), Positives = 304/472 (64%), Gaps = 30/472 (6%)
Query: 618 VSEHCTRGSLQDLLAQR-----EIKLDWMFKSSLLLDLIKGIRYLHH-RGVAHGRLKSRN 671
V E+C RGSL+++L +DW FK S+L D+ KG+ YLH + HGRLKS N
Sbjct: 560 VIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTN 619
Query: 672 CIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALERRGTLAGDVFS 731
C+VD R V+KITD G +L PP+ + LWTAPE LR + ++G DV+S
Sbjct: 620 CVVDSRMVVKITDFGCNSIL--------PPKKD--LWTAPEHLRQANISQKG----DVYS 665
Query: 732 LAIIMQEVVCRSAPYAMLELTPE-EVVQRVRSPPPL--CRP---LVSMDQAPVECILLMK 785
II QE++ R + L E + RV + + RP L + ++ +E LL+K
Sbjct: 666 YGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVK 725
Query: 786 QCWAEQPELRPSMDHT----FDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEE 841
CW E PE RP +F + + + +D+++R L+ YS NLE L+ ERT+
Sbjct: 726 NCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQL 785
Query: 842 LELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEV 901
+ E+ + DRL +LP V ++LK VEPE +E+VT+YFSDIVGFTTI S P+EV
Sbjct: 786 YKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEV 845
Query: 902 VDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVG 961
VD+LND+Y FD I+ HDVYKVETIGDAYMVASGLP+RNG RHA +IA M+L+ILS +G
Sbjct: 846 VDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMG 905
Query: 962 TFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVN 1021
TF + H+P +P+ IRIG+HSGPC AGVVG+ MPRYCLFGDTVNTASRMESTGLP RIHV+
Sbjct: 906 TFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVS 965
Query: 1022 LSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRRGFNKPIPKPPDLQ 1073
ST+ IL+ + + E+RG T LKG+G E T+WL G + +P PP ++
Sbjct: 966 GSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVE 1017
>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
sapiens]
Length = 455
Score = 166 bits (421), Expect = 9e-41
Identities = 107/274 (39%), Positives = 153/274 (55%), Gaps = 14/274 (5%)
Query: 811 GRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTP 870
G + D + + L + + LE + + LE EK+KT LL + P VA+ L G
Sbjct: 181 GEQARAQDGLKKRLGKLKATLE----QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV 236
Query: 871 VEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDA 930
V+ + F VT+ FSDIVGFT I + P++V+ +LN LYT FD G DVYKVETIGDA
Sbjct: 237 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 296
Query: 931 YMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVG 990
Y VA GL + HA +IA M+L ++ H P+++RIGLHSG AGVVG
Sbjct: 297 YCVAGGL-HKESDTHAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVG 353
Query: 991 LTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGA 1050
+ MPRYCLFG+ V A++ ES +P +I+V+ +T +L+ G+ R R EL
Sbjct: 354 VKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDC-PGFVFTPRSREELPPNFP 412
Query: 1051 EDT-----FWLVGRRGFN-KPIPKPPDLQPGSSN 1078
+ F ++G N KP + D++ G++N
Sbjct: 413 SEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNAN 446
>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 166 bits (421), Expect = 9e-41
Identities = 107/274 (39%), Positives = 153/274 (55%), Gaps = 14/274 (5%)
Query: 811 GRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTP 870
G + D + + L + + LE + + LE EK+KT LL + P VA+ L G
Sbjct: 416 GEQARAQDGLKKRLGKLKATLE----QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV 471
Query: 871 VEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDA 930
V+ + F VT+ FSDIVGFT I + P++V+ +LN LYT FD G DVYKVETIGDA
Sbjct: 472 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 531
Query: 931 YMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVG 990
Y VA GL + HA +IA M+L ++ H P+++RIGLHSG AGVVG
Sbjct: 532 YCVAGGL-HKESDTHAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVG 588
Query: 991 LTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGA 1050
+ MPRYCLFG+ V A++ ES +P +I+V+ +T +L+ G+ R R EL
Sbjct: 589 VKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDC-PGFVFTPRSREELPPNFP 647
Query: 1051 EDT-----FWLVGRRGFN-KPIPKPPDLQPGSSN 1078
+ F ++G N KP + D++ G++N
Sbjct: 648 SEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNAN 681
>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 166 bits (421), Expect = 9e-41
Identities = 107/274 (39%), Positives = 153/274 (55%), Gaps = 14/274 (5%)
Query: 811 GRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTP 870
G + D + + L + + LE + + LE EK+KT LL + P VA+ L G
Sbjct: 416 GEQARAQDGLKKRLGKLKATLE----QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV 471
Query: 871 VEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDA 930
V+ + F VT+ FSDIVGFT I + P++V+ +LN LYT FD G DVYKVETIGDA
Sbjct: 472 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 531
Query: 931 YMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVG 990
Y VA GL + HA +IA M+L ++ H P+++RIGLHSG AGVVG
Sbjct: 532 YCVAGGL-HKESDTHAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVG 588
Query: 991 LTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGA 1050
+ MPRYCLFG+ V A++ ES +P +I+V+ +T +L+ G+ R R EL
Sbjct: 589 VKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDC-PGFVFTPRSREELPPNFP 647
Query: 1051 EDT-----FWLVGRRGFN-KPIPKPPDLQPGSSN 1078
+ F ++G N KP + D++ G++N
Sbjct: 648 SEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNAN 681
>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 166 bits (421), Expect = 9e-41
Identities = 107/274 (39%), Positives = 153/274 (55%), Gaps = 14/274 (5%)
Query: 811 GRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTP 870
G + D + + L + + LE + + LE EK+KT LL + P VA+ L G
Sbjct: 416 GEQARAQDGLKKRLGKLKATLE----QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV 471
Query: 871 VEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDA 930
V+ + F VT+ FSDIVGFT I + P++V+ +LN LYT FD G DVYKVETIGDA
Sbjct: 472 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 531
Query: 931 YMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVG 990
Y VA GL + HA +IA M+L ++ H P+++RIGLHSG AGVVG
Sbjct: 532 YCVAGGL-HKESDTHAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVG 588
Query: 991 LTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGA 1050
+ MPRYCLFG+ V A++ ES +P +I+V+ +T +L+ G+ R R EL
Sbjct: 589 VKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDC-PGFVFTPRSREELPPNFP 647
Query: 1051 EDT-----FWLVGRRGFN-KPIPKPPDLQPGSSN 1078
+ F ++G N KP + D++ G++N
Sbjct: 648 SEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNAN 681
>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 166 bits (421), Expect = 9e-41
Identities = 107/274 (39%), Positives = 153/274 (55%), Gaps = 14/274 (5%)
Query: 811 GRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTP 870
G + D + + L + + LE + + LE EK+KT LL + P VA+ L G
Sbjct: 416 GEQARAQDGLKKRLGKLKATLE----QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV 471
Query: 871 VEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDA 930
V+ + F VT+ FSDIVGFT I + P++V+ +LN LYT FD G DVYKVETIGDA
Sbjct: 472 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 531
Query: 931 YMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVG 990
Y VA GL + HA +IA M+L ++ H P+++RIGLHSG AGVVG
Sbjct: 532 YCVAGGL-HKESDTHAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVG 588
Query: 991 LTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGA 1050
+ MPRYCLFG+ V A++ ES +P +I+V+ +T +L+ G+ R R EL
Sbjct: 589 VKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDC-PGFVFTPRSREELPPNFP 647
Query: 1051 EDT-----FWLVGRRGFN-KPIPKPPDLQPGSSN 1078
+ F ++G N KP + D++ G++N
Sbjct: 648 SEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNAN 681
>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
Length = 732
Score = 164 bits (416), Expect = 3e-40
Identities = 115/287 (40%), Positives = 161/287 (56%), Gaps = 22/287 (7%)
Query: 796 PSMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEE-LELEKQKTDRLLT 854
P D T D+ I G + D + + +++ + LE RT + LE EK+KT LL
Sbjct: 444 PIHDATRDV---ILVGEQAKAQDGLKKRMDKLKATLE-----RTHQALEEEKKKTVDLLY 495
Query: 855 QMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDA 914
+ P VA+ L G V+ F+ VT+ FSDIVGFT I A P++V+ +LN+LYT FD
Sbjct: 496 SIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDH 555
Query: 915 IIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVR 974
G D+YKVETIGDAY VA+GL R HA IA M+L ++ + + P++
Sbjct: 556 QCGFLDIYKVETIGDAYCVAAGL-HRKSLCHAKPIALMALKMMEL--SEEVLTPDGRPIQ 612
Query: 975 IRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSG 1034
+RIG+HSG +AGVVG+ MPRYCLFG+ V AS+ ES P RI+V+ +T +L+ +S
Sbjct: 613 MRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREES- 671
Query: 1035 YQVELRGRTELKGKGAED----TFWLVGRRGFNKPIPKPPDLQPGSS 1077
+ R R EL ++ ++L R G PKPP SS
Sbjct: 672 FTFIPRSREELPDNFPKEIPGICYFLEVRTG-----PKPPKPSLSSS 713
>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
sapiens]
Length = 624
Score = 162 bits (409), Expect = 2e-39
Identities = 93/214 (43%), Positives = 128/214 (59%), Gaps = 7/214 (3%)
Query: 811 GRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTP 870
G + D + + L + + LE + + LE EK+KT LL + P VA+ L G
Sbjct: 416 GEQARAQDGLKKRLGKLKATLE----QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV 471
Query: 871 VEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDA 930
V+ + F VT+ FSDIVGFT I + P++V+ +LN LYT FD G DVYKVETIGDA
Sbjct: 472 VQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA 531
Query: 931 YMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVG 990
Y VA GL + HA +IA M+L ++ H P+++RIGLHSG AGVVG
Sbjct: 532 YCVAGGL-HKESDTHAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVG 588
Query: 991 LTMPRYCLFGDTVNTASRMESTGLPYRIHVNLST 1024
+ MPRYCLFG+ V A++ ES +P +I+V+ +T
Sbjct: 589 VKMPRYCLFGNNVTLANKFESCSVPRKINVSPTT 622
>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
Length = 619
Score = 160 bits (405), Expect = 6e-39
Identities = 102/258 (39%), Positives = 141/258 (54%), Gaps = 14/258 (5%)
Query: 824 LEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYF 883
L Q L D ++ LE EK+KTD LL +LPPSVA L+ PV + ++ VT+ F
Sbjct: 365 LTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILF 424
Query: 884 SDIVGFTTISAMSEP----IEVVDLLNDLYTLFDAIIGSHD---VYKVETIGDAYMVASG 936
S IVGF + +++V+LLNDLYT FD + S VYKVET+GD YM SG
Sbjct: 425 SGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSG 484
Query: 937 LPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRY 996
LP+ HA I +++LD++ G ++ V+I IG+H+G V GV+G MPRY
Sbjct: 485 LPEPC-IHHARSICHLALDMMEIAGQVQV---DGESVQITIGIHTGEVVTGVIGQRMPRY 540
Query: 997 CLFGDTVNTASRMESTGLPYRIHVNLSTVGILRA---LDSGYQVELRGRTELKGKGAEDT 1053
CLFG+TVN SR E+TG +I+V+ T L + D + +E RG +KGK
Sbjct: 541 CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ 600
Query: 1054 FWLVGRRGFNKPIPKPPD 1071
W + R+ K D
Sbjct: 601 VWFLSRKNTGTEETKQDD 618
>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
Length = 1168
Score = 119 bits (298), Expect = 2e-26
Identities = 83/237 (35%), Positives = 127/237 (53%), Gaps = 25/237 (10%)
Query: 840 EELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQ----VTLYFSDIVGFTT---- 891
EE+E + RLL +LP VA E + Q V + F+ I F+
Sbjct: 935 EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVE 994
Query: 892 ISAMSEPIEVVDLLNDLYTLFDAIIGSH---DVYKVETIGDAYMVASGLPQRN----GQR 944
+ A +E +E + LLN++ FD II + K++TIG YM ASGL G+
Sbjct: 995 LEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRS 1054
Query: 945 HAAEIANMSLDILSAVGTFRMRHMPEVPV---RIRIGLHSGPCVAGVVGLTMPRYCLFGD 1001
H +A+ ++ ++ +M+H+ E +++IGL+ GP VAGV+G P+Y ++G+
Sbjct: 1055 HITALADYAMRLME-----QMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGN 1109
Query: 1002 TVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVG 1058
TVN +SRM+STG+P RI V +L A GYQ+E RG ++KGKG T++L G
Sbjct: 1110 TVNVSSRMDSTGVPDRIQVTTDLYQVLAA--KGYQLECRGVVKVKGKGEMTTYFLNG 1164
Score = 101 bits (251), Expect = 4e-21
Identities = 67/225 (29%), Positives = 116/225 (51%), Gaps = 23/225 (10%)
Query: 842 LELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYF----------EQVTLYFSDIVGFTT 891
L+ E ++ +RLL +LP VA +K + E + V++ F+DI GFT+
Sbjct: 331 LQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTS 390
Query: 892 ISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIAN 951
+++ E+V LN+L+ FD + + +++ +GD Y SGLP+ HA
Sbjct: 391 LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVE 449
Query: 952 MSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMES 1011
M +D++ A+ +R + V V +R+G+HSG GV+GL ++ ++ + V A+ ME+
Sbjct: 450 MGVDMIEAISL--VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEA 507
Query: 1012 TGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWL 1056
G RIH+ +T L+ L+ Y+VE G+G E +L
Sbjct: 508 GGRAGRIHITRAT---LQYLNGDYEVE-------PGRGGERNAYL 542
>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
Length = 1115
Score = 119 bits (298), Expect = 2e-26
Identities = 83/237 (35%), Positives = 127/237 (53%), Gaps = 25/237 (10%)
Query: 840 EELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQ----VTLYFSDIVGFTT---- 891
EE+E + RLL +LP VA E + Q V + F+ I F+
Sbjct: 882 EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVE 941
Query: 892 ISAMSEPIEVVDLLNDLYTLFDAIIGSH---DVYKVETIGDAYMVASGLPQRN----GQR 944
+ A +E +E + LLN++ FD II + K++TIG YM ASGL G+
Sbjct: 942 LEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRS 1001
Query: 945 HAAEIANMSLDILSAVGTFRMRHMPEVPV---RIRIGLHSGPCVAGVVGLTMPRYCLFGD 1001
H +A+ ++ ++ +M+H+ E +++IGL+ GP VAGV+G P+Y ++G+
Sbjct: 1002 HITALADYAMRLME-----QMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGN 1056
Query: 1002 TVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVG 1058
TVN +SRM+STG+P RI V +L A GYQ+E RG ++KGKG T++L G
Sbjct: 1057 TVNVSSRMDSTGVPDRIQVTTDLYQVLAA--KGYQLECRGVVKVKGKGEMTTYFLNG 1111
Score = 101 bits (251), Expect = 4e-21
Identities = 67/225 (29%), Positives = 116/225 (51%), Gaps = 23/225 (10%)
Query: 842 LELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYF----------EQVTLYFSDIVGFTT 891
L+ E ++ +RLL +LP VA +K + E + V++ F+DI GFT+
Sbjct: 331 LQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTS 390
Query: 892 ISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIAN 951
+++ E+V LN+L+ FD + + +++ +GD Y SGLP+ HA
Sbjct: 391 LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVE 449
Query: 952 MSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMES 1011
M +D++ A+ +R + V V +R+G+HSG GV+GL ++ ++ + V A+ ME+
Sbjct: 450 MGVDMIEAISL--VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEA 507
Query: 1012 TGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWL 1056
G RIH+ +T L+ L+ Y+VE G+G E +L
Sbjct: 508 GGRAGRIHITRAT---LQYLNGDYEVE-------PGRGGERNAYL 542
>gi|34486092 adenylate cyclase 5 [Homo sapiens]
Length = 1261
Score = 116 bits (291), Expect = 1e-25
Identities = 83/240 (34%), Positives = 128/240 (53%), Gaps = 25/240 (10%)
Query: 837 ERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQ----VTLYFSDIVGFTT- 891
E EE+E + RLL +LP VA E + Q V + F+ I F+
Sbjct: 1024 EEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEF 1083
Query: 892 ---ISAMSEPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLPQRN---- 941
+ A +E +E + LLN++ FD II + K++TIG YM ASGL
Sbjct: 1084 YVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKV 1143
Query: 942 GQRHAAEIANMSLDILSAVGTFRMRHMPEVPV---RIRIGLHSGPCVAGVVGLTMPRYCL 998
G+ H +A+ ++ ++ +M+++ E +++IGL+ GP VAGV+G P+Y +
Sbjct: 1144 GKTHIKALADFAMKLMD-----QMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDI 1198
Query: 999 FGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVG 1058
+G+TVN ASRM+STG+P RI V +L A + YQ+E RG ++KGKG T++L G
Sbjct: 1199 WGNTVNVASRMDSTGVPDRIQVTTDMYQVLAA--NTYQLECRGVVKVKGKGEMMTYFLNG 1256
Score = 100 bits (250), Expect = 6e-21
Identities = 63/204 (30%), Positives = 107/204 (52%), Gaps = 16/204 (7%)
Query: 845 EKQKTDRLLTQMLPPSVAEALKTGTPVEPEYF----------EQVTLYFSDIVGFTTISA 894
E Q+ +RLL +LP VA +K + E + V++ F+DI GFT++++
Sbjct: 424 ENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLAS 483
Query: 895 MSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSL 954
E+V LN+L+ FD + + +++ +GD Y SGLP+ HA M +
Sbjct: 484 QCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVEMGM 542
Query: 955 DILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGL 1014
D++ A+ +R + V V +R+G+HSG GV+GL ++ ++ + V A+ ME+ G
Sbjct: 543 DMIEAISL--VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK 600
Query: 1015 PYRIHVNLSTVGILRALDSGYQVE 1038
RIH+ +T L L+ Y+VE
Sbjct: 601 AGRIHITKAT---LNYLNGDYEVE 621
>gi|31083193 adenylate cyclase 1 [Homo sapiens]
Length = 1119
Score = 111 bits (278), Expect = 3e-24
Identities = 82/262 (31%), Positives = 135/262 (51%), Gaps = 23/262 (8%)
Query: 789 AEQPELRPSMDHTFDLFKNINK-GRKTNIID--SMLRMLEQYSSNLEDLIRERTEELELE 845
A++P L ++ LF +N G I+ S + Q S +ED +R LE E
Sbjct: 205 AKRPRLWRTLGANALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLR-----LEDE 259
Query: 846 KQKTDRLLTQMLPPSVAEALKTGTPVEPEYF---------EQVTLYFSDIVGFTTISAMS 896
+K +RLL +LP +VA +K PE + V++ F+DIVGFT +++
Sbjct: 260 NEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQC 319
Query: 897 EPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDI 956
E+V LLN+L+ FD + + +++ +GD Y SGL Q HA M LD+
Sbjct: 320 TAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTD-HAHCCVEMGLDM 378
Query: 957 LSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPY 1016
+ + + + EV + +R+GLH+G + GV+GL +Y ++ + V A+ ME+ GLP
Sbjct: 379 IDTITS--VAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPG 436
Query: 1017 RIHVNLSTVGILRALDSGYQVE 1038
++H+ +T L L+ Y+VE
Sbjct: 437 KVHITKTT---LACLNGDYEVE 455
Score = 108 bits (271), Expect = 2e-23
Identities = 78/265 (29%), Positives = 131/265 (49%), Gaps = 26/265 (9%)
Query: 817 IDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYF 876
+D LR+ +++ E E E++E K R+L +LP VA+ P + +
Sbjct: 805 VDIRLRLDYLWAAQAE----EEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLY 860
Query: 877 ----EQVTLYFSDIVGFTT----ISAMSEPIEVVDLLNDLYTLFDAIIGSH---DVYKVE 925
QV + F+ I F + + +E + LLN++ FD ++ D+ K++
Sbjct: 861 YQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIK 920
Query: 926 TIGDAYMVASGLPQRNGQR-------HAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIG 978
TIG YM A GL +G + H + +A+ ++++ + + + +R+G
Sbjct: 921 TIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFV--LRVG 978
Query: 979 LHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVE 1038
++ GP VAGV+G P+Y ++G+TVN ASRM+STG+ RI V +LR Y
Sbjct: 979 INVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCP--YHFV 1036
Query: 1039 LRGRTELKGKGAEDTFWLVGRRGFN 1063
RG+ +KGKG T++L GR N
Sbjct: 1037 CRGKVSVKGKGEMLTYFLEGRTDGN 1061
>gi|4557257 adenylate cyclase 8 [Homo sapiens]
Length = 1251
Score = 110 bits (274), Expect = 1e-23
Identities = 85/274 (31%), Positives = 135/274 (49%), Gaps = 29/274 (10%)
Query: 826 QYSSNLEDLIR----ERTEELELEKQKTDRLLTQMLPPSVA----EALKTGTPVEPEYFE 877
+Y++ L+ L R E E++ ++ + +L +LP VA E + + + ++
Sbjct: 920 EYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYD 979
Query: 878 QVTLYFSDIVGFTTISAMSEP----IEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDA 930
V + F+ I GF + +E +E + LLN++ FD ++G D+ K++TIG
Sbjct: 980 AVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGST 1039
Query: 931 YMVASGLPQRNGQ-----RHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCV 985
YM SGL Q H +A+ SL + ++ +RIG+ G V
Sbjct: 1040 YMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNF--ELRIGISHGSVV 1097
Query: 986 AGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTEL 1045
AGV+G P+Y ++G TVN ASRM+STG+ RI V T IL+ D G+ + RG +
Sbjct: 1098 AGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILK--DQGFAFDYRGEIYV 1155
Query: 1046 KG----KGAEDTFWLVGRRGFNKPIPKPPDLQPG 1075
KG +G T++L+GR N P PP PG
Sbjct: 1156 KGISEQEGKIKTYFLLGRVQPN-PFILPPRRLPG 1188
Score = 109 bits (273), Expect = 1e-23
Identities = 70/210 (33%), Positives = 113/210 (53%), Gaps = 19/210 (9%)
Query: 842 LELEKQKTDRLLTQMLPPSVA-EALKTGTPVEPEY------------FEQVTLYFSDIVG 888
LE E Q+ +RL+ +LP V E + T VE E+ +E V++ F+D+ G
Sbjct: 363 LETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKG 422
Query: 889 FTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAE 948
FT +S E+V +LN+L+ FD + H +++ +GD Y SGLP+ Q HA
Sbjct: 423 FTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPR-QDHAHC 481
Query: 949 IANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASR 1008
M L ++ + R R +V +RIG+HSG + GV+GL ++ ++ V+ A++
Sbjct: 482 CVEMGLSMIKTIRYVRSRTKHDVD--MRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANK 539
Query: 1009 MESTGLPYRIHVNLSTVGILRALDSGYQVE 1038
+ES G+P RIH++ +T L L+ Y VE
Sbjct: 540 LESGGIPGRIHISKAT---LDCLNGDYNVE 566
>gi|4557255 adenylate cyclase 7 [Homo sapiens]
Length = 1080
Score = 110 bits (274), Expect = 1e-23
Identities = 65/217 (29%), Positives = 118/217 (54%), Gaps = 25/217 (11%)
Query: 841 ELELEKQKTDRLLTQMLPPSVAEALKTGT-------------------PVEPEYFEQVTL 881
+L +EK++ + LL +LP ++ +K + + + V++
Sbjct: 221 KLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSI 280
Query: 882 YFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRN 941
++DIVGFT +++ P E+V +LN+L+ FD I +++ +++ +GD Y SGLP +
Sbjct: 281 LYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPV-S 339
Query: 942 GQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGD 1001
HA M LD+ A+ ++R V + +R+G+HSG + GV+GL +Y ++
Sbjct: 340 LPTHARNCVKMGLDMCQAIK--QVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSH 397
Query: 1002 TVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVE 1038
V+ A+RME+ G+P R+H+ +T L+ LD Y+VE
Sbjct: 398 DVSLANRMEAAGVPGRVHITEAT---LKHLDKAYEVE 431
Score = 102 bits (255), Expect = 2e-21
Identities = 76/241 (31%), Positives = 119/241 (49%), Gaps = 25/241 (10%)
Query: 836 RERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQ----VTLYFSDI----V 887
++ EE E + LL +LP VA A G + +++ Q V + F+ + V
Sbjct: 832 KKEHEEFETMENVNRLLLENVLPAHVA-AHFIGDKLNEDWYHQSYDCVCVMFASVPDFKV 890
Query: 888 GFTTISAMSEPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLPQRNGQR 944
+T E +E + LLN++ FD ++ V K++TIG YM A+GL +G
Sbjct: 891 FYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHE 950
Query: 945 ---------HAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPR 995
H + S+ ++S + R+R+G++ GP +AGV+G P+
Sbjct: 951 NQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSF--RLRVGINHGPVIAGVIGARKPQ 1008
Query: 996 YCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFW 1055
Y ++G+TVN ASRMESTG +I V T IL+ L GY E RG +KGKG T++
Sbjct: 1009 YDIWGNTVNVASRMESTGELGKIQVTEETCTILQGL--GYSCECRGLINVKGKGELRTYF 1066
Query: 1056 L 1056
+
Sbjct: 1067 V 1067
>gi|115387102 adenylate cyclase 2 [Homo sapiens]
Length = 1091
Score = 107 bits (268), Expect = 5e-23
Identities = 72/234 (30%), Positives = 122/234 (52%), Gaps = 26/234 (11%)
Query: 824 LEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKT-----------GTPVE 872
L+Q + + I+ R + LE EK++ +RLL +LP +A +K G
Sbjct: 216 LQQTYQDTCNCIKSRIK-LEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMEN 274
Query: 873 PEYFEQ--------VTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKV 924
F V++ ++DIVGFT +++ P E+V +LN+L+ FD I ++ ++
Sbjct: 275 TNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRI 334
Query: 925 ETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPC 984
+ +GD Y SGLP + HA M LD+ A+ ++R V + +R+G+HSG
Sbjct: 335 KILGDCYYCVSGLP-ISLPNHAKNCVKMGLDMCEAIK--KVRDATGVDINMRVGVHSGNV 391
Query: 985 VAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVE 1038
+ GV+GL +Y ++ V A+ ME+ G+P R+H++ T L L+ Y+VE
Sbjct: 392 LCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVT---LEHLNGAYKVE 442
Score = 100 bits (249), Expect = 8e-21
Identities = 76/240 (31%), Positives = 117/240 (48%), Gaps = 21/240 (8%)
Query: 836 RERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQ----VTLYFSDIVGF-- 889
++ EE+E + LL +LP VAE + E + Q V + F+ I F
Sbjct: 839 KKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKE 898
Query: 890 --TTISAMSEPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLPQRNGQR 944
T E +E + LLN++ FD ++ V K++TIG YM A+GL Q
Sbjct: 899 FYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQE 958
Query: 945 HAAE-------IANMSLDILSAVGTFRMRHMPEV-PVRIRIGLHSGPCVAGVVGLTMPRY 996
H+ E I M + VG + ++R+G++ GP +AGV+G P+Y
Sbjct: 959 HSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQY 1018
Query: 997 CLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWL 1056
++G+TVN ASRM+STG+ +I V T +L+ L GY RG +KGKG T+++
Sbjct: 1019 DIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTL--GYTCTCRGIINVKGKGDLKTYFV 1076
>gi|24497587 adenylate cyclase 4 [Homo sapiens]
Length = 1077
Score = 107 bits (266), Expect = 8e-23
Identities = 81/242 (33%), Positives = 124/242 (51%), Gaps = 23/242 (9%)
Query: 835 IRERTEELELEKQKTDRLLTQMLPPSVAEAL----KTGTPVEPEYFEQVTLYFSDIVGFT 890
+R+ EE E + T LL +LP VA + + + +E V + F+ + F
Sbjct: 824 LRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFK 883
Query: 891 TISAMS----EPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLPQRNGQ 943
+ S E +E + LLN++ FD ++ V K++TIG YM A+GL +GQ
Sbjct: 884 EFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQ 943
Query: 944 RHAAEIANMSLDILSAVGTFRMRHMPEVPV---------RIRIGLHSGPCVAGVVGLTMP 994
A + A S L + F + ++ V R+R+GL+ GP VAGV+G P
Sbjct: 944 -DAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKP 1002
Query: 995 RYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTF 1054
+Y ++G+TVN ASRMESTG+ +I V T L++L GY RG ++KGKG T+
Sbjct: 1003 QYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSL--GYTCYSRGVIKVKGKGQLCTY 1060
Query: 1055 WL 1056
+L
Sbjct: 1061 FL 1062
Score = 105 bits (261), Expect = 3e-22
Identities = 68/219 (31%), Positives = 113/219 (51%), Gaps = 25/219 (11%)
Query: 842 LELEKQKTDRLLTQMLPPSVAEALKT--------GTPVEPEY-----------FEQVTLY 882
L+ EK+ + LL +LP +A +K G PE + V++
Sbjct: 216 LDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVL 275
Query: 883 FSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNG 942
++DIVGFT +++ P E+V +LN+L+ FD I H+ +++ +GD Y SGLP +
Sbjct: 276 YADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLP-LSL 334
Query: 943 QRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDT 1002
HA M LD+ A+ ++R V + +R+G+HSG + GV+GL +Y ++
Sbjct: 335 PDHAINCVRMGLDMCRAIR--KLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHD 392
Query: 1003 VNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRG 1041
V A+ ME+ G+P R+H+ +T+ +L Y VE G
Sbjct: 393 VTLANHMEAGGVPGRVHITGATLALLA---GAYAVEDAG 428
>gi|50959205 adenylate cyclase 9 [Homo sapiens]
Length = 1353
Score = 99.0 bits (245), Expect = 2e-20
Identities = 68/244 (27%), Positives = 125/244 (51%), Gaps = 15/244 (6%)
Query: 797 SMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELE--LEKQKTDRLLT 854
S+ H DL + K K +I S++ + +DL+++ EE E +++ T
Sbjct: 316 SIMHGKDL--EVEKALKERMIHSVMPRIIA-----DDLMKQGDEESENSVKRHATSSPKN 368
Query: 855 QMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDA 914
+ S+ +A P + + E+V++ F+DIVGFT +SA +V LLNDL+ FD
Sbjct: 369 RKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDR 428
Query: 915 IIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVR 974
+ K+ T+GD Y +G P+ HA M L ++ A+ F + V
Sbjct: 429 LCEETKCEKISTLGDCYYCVAGCPEPRAD-HAYCCIEMGLGMIKAIEQFCQE--KKEMVN 485
Query: 975 IRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSG 1034
+R+G+H+G + G++G+ ++ ++ + VN A+ ME G+ ++H++ +T + LD
Sbjct: 486 MRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATA---KYLDDR 542
Query: 1035 YQVE 1038
Y++E
Sbjct: 543 YEME 546
Score = 97.8 bits (242), Expect = 5e-20
Identities = 74/240 (30%), Positives = 119/240 (49%), Gaps = 19/240 (7%)
Query: 827 YSSNLE-DLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSD 885
Y ++E DL R + + + + + D LL ++P VAE LK + + + F+
Sbjct: 1008 YHGDVEADLHRTKIQSM---RDQADWLLRNIIPYHVAEQLKVSQTYSKNH-DSGGVIFAS 1063
Query: 886 IVGFTTISAMSEP--IEVVDLLNDLYTLFDAIIGSHD---VYKVETIGDAYMVASGLPQR 940
IV F+ + E +LN+L FD ++ D + K++TIG YM ASGL
Sbjct: 1064 IVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTA 1123
Query: 941 NGQ------RHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMP 994
Q H + + +++ V F +M ++R+G + GP AGV+G T
Sbjct: 1124 QAQDGSHPQEHLQILFEFAKEMMRVVDDFN-NNMLWFNFKLRVGFNHGPLTAGVIGTTKL 1182
Query: 995 RYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTF 1054
Y ++GDTVN ASRM++TG+ RI V+ + +L + GY + RG +KGKG T+
Sbjct: 1183 LYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKM--GYDFDYRGTVNVKGKGQMKTY 1240
>gi|148536830 adenylate cyclase 3 [Homo sapiens]
Length = 1144
Score = 98.6 bits (244), Expect = 3e-20
Identities = 60/201 (29%), Positives = 108/201 (53%), Gaps = 16/201 (7%)
Query: 842 LELEKQKTDRLLTQMLPPSVAEAL-----KTGTPVEPEYF--------EQVTLYFSDIVG 888
LE + Q+ + L+ +LP VA+ + K + + + F E V++ F+DIVG
Sbjct: 268 LEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVG 327
Query: 889 FTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAE 948
FT +S+ E+V LLN+L+ FD + + +++ +GD Y GLP + HA
Sbjct: 328 FTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYR-EDHAVC 386
Query: 949 IANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASR 1008
M L ++ A+ +R + V +R+G+H+G + GV+G +Y ++ V A++
Sbjct: 387 SILMGLAMVEAIS--YVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANK 444
Query: 1009 MESTGLPYRIHVNLSTVGILR 1029
ME+ G+P R+H++ ST+ L+
Sbjct: 445 MEAGGIPGRVHISQSTMDCLK 465
Score = 96.3 bits (238), Expect = 1e-19
Identities = 78/271 (28%), Positives = 135/271 (49%), Gaps = 36/271 (13%)
Query: 817 IDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAE----ALKTGTPVE 872
++ + R L + + D +ER E+ ++ + L+T MLP VA + K +
Sbjct: 860 VEKLARTLFLWKIEVHDQ-KERVYEM---RRWNEALVTNMLPEHVARHFLGSKKRDEELY 915
Query: 873 PEYFEQVTLYFSDIVGF----TTISAMSEPIEVVDLLNDLYTLFDAIIGSHD---VYKVE 925
+ ++++ + F+ + F T S + IE + LN++ + FD+++ + + K++
Sbjct: 916 SQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIK 975
Query: 926 TIGDAYMVASGLP-----------------QRNGQRHAAEIANMSLDILSAVGTFRMRHM 968
TIG YM ASG+ +R +H A++A+ +L + + +
Sbjct: 976 TIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSF 1035
Query: 969 PEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGIL 1028
+RIG++ G +AGV+G P Y ++G+TVN ASRMESTG+ I V T IL
Sbjct: 1036 NNF--MLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVIL 1093
Query: 1029 RALDSGYQVELRGRTELKGKGAEDTFWLVGR 1059
R + G++ RG +KGKG TF+L GR
Sbjct: 1094 R--EYGFRFVRRGPIFVKGKGELLTFFLKGR 1122
>gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinase 1
[Homo sapiens]
Length = 671
Score = 90.1 bits (222), Expect = 1e-17
Identities = 73/278 (26%), Positives = 126/278 (45%), Gaps = 36/278 (12%)
Query: 584 LQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFK 643
+ LRH V LG+ + EG ++V E+ +G+L +L + E+ K
Sbjct: 67 MNRLRHSRVVKLLGVIIE----------EGKYSLVMEYMEKGNLMHVL-KAEMSTPLSVK 115
Query: 644 SSLLLDLIKGIRYLHHRGVAHGRLKSRNCIVDGRFVLKITDHG--------------HGR 689
++L++I+G+ YLH +GV H LK N +VD F +KI D G H
Sbjct: 116 GRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNE 175
Query: 690 LLEAQKVLPEPPRAEDQLWTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPYAML 749
L E + + APE L D + + T DV+S A+++ + PY
Sbjct: 176 LREVDGTAKK--NGGTLYYMAPEHLND--VNAKPTEKSDVYSFAVVLWAIFANKEPYEN- 230
Query: 750 ELTPEEVVQRVRSPPPLCRPLVS--MDQAPVECILLMKQCWAEQPELRPSMDHTFDLFKN 807
+ ++++ ++S RP V + P E I LMK CW PE RP+ + F+
Sbjct: 231 AICEQQLIMCIKSGN---RPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRP 287
Query: 808 INKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELE 845
+ ++ ++ L++ SN E+ + +R + L+L+
Sbjct: 288 FYLSQLEESVEEDVKSLKKEYSN-ENAVVKRMQSLQLD 324
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 82.0 bits (201), Expect = 3e-15
Identities = 67/261 (25%), Positives = 113/261 (43%), Gaps = 34/261 (13%)
Query: 552 IGVYEGDRVWLKKFPGDQHIAIRPATKTAFSK---------LQELRHEN-VALYLGLFLA 601
+G + VW+ + G +A++ + + S +++L+H+ V LY
Sbjct: 251 LGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLY------ 304
Query: 602 RGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQRE-IKLDWMFKSSLLLDLIKGIRYLHHR 660
A + + + +++E+ GSL D L IKL + + +G+ ++ R
Sbjct: 305 ------AVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEER 358
Query: 661 GVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALE 720
H L++ N +V KI D G RL+E + WTAPE +
Sbjct: 359 NYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTF- 417
Query: 721 RRGTLAGDVFSLAIIMQEVVCRSA-PYAMLELTPEEVVQRVRSPPPLCRPLVSMDQAPVE 779
T+ DV+S I++ E+V PY +T EV+Q + + RP D P E
Sbjct: 418 ---TIKSDVWSFGILLTEIVTHGRIPYP--GMTNPEVIQNLERGYRMVRP----DNCPEE 468
Query: 780 CILLMKQCWAEQPELRPSMDH 800
LM+ CW E+PE RP+ D+
Sbjct: 469 LYQLMRLCWKERPEDRPTFDY 489
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 82.0 bits (201), Expect = 3e-15
Identities = 67/261 (25%), Positives = 113/261 (43%), Gaps = 34/261 (13%)
Query: 552 IGVYEGDRVWLKKFPGDQHIAIRPATKTAFSK---------LQELRHEN-VALYLGLFLA 601
+G + VW+ + G +A++ + + S +++L+H+ V LY
Sbjct: 251 LGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLY------ 304
Query: 602 RGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQRE-IKLDWMFKSSLLLDLIKGIRYLHHR 660
A + + + +++E+ GSL D L IKL + + +G+ ++ R
Sbjct: 305 ------AVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEER 358
Query: 661 GVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALE 720
H L++ N +V KI D G RL+E + WTAPE +
Sbjct: 359 NYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTF- 417
Query: 721 RRGTLAGDVFSLAIIMQEVVCRSA-PYAMLELTPEEVVQRVRSPPPLCRPLVSMDQAPVE 779
T+ DV+S I++ E+V PY +T EV+Q + + RP D P E
Sbjct: 418 ---TIKSDVWSFGILLTEIVTHGRIPYP--GMTNPEVIQNLERGYRMVRP----DNCPEE 468
Query: 780 CILLMKQCWAEQPELRPSMDH 800
LM+ CW E+PE RP+ D+
Sbjct: 469 LYQLMRLCWKERPEDRPTFDY 489
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 78.2 bits (191), Expect = 4e-14
Identities = 74/254 (29%), Positives = 114/254 (44%), Gaps = 40/254 (15%)
Query: 552 IGVYEGDRVWLKKFPGDQHIAIRPATKTAF----SKLQELRHENVALYLGLFLARGAEGP 607
+G Y G++V +K D AT AF S + +LRH N+ LG+ +
Sbjct: 211 LGDYRGNKVAVKCIKND-------ATAQAFLAEASVMTQLRHSNLVQLLGVIVEE----- 258
Query: 608 AALWEGNLAVVSEHCTRGSLQDLLAQREIKL---DWMFKSSLLLDLIKGIRYLHHRGVAH 664
+G L +V+E+ +GSL D L R + D + K SL D+ + + YL H
Sbjct: 259 ----KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL--DVCEAMEYLEGNNFVH 312
Query: 665 GRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALERRGT 724
L +RN +V V K++D G + + + + P WTAPE LR E++ +
Sbjct: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLP----VKWTAPEALR----EKKFS 364
Query: 725 LAGDVFSLAIIMQEVVC-RSAPYAMLELTPEEVVQRVRSPPPLCRPLVSMDQAPVECILL 783
DV+S I++ E+ PY + L ++VV RV + P D P +
Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPL--KDVVPRVEKGYKMDAP----DGCPPAVYEV 418
Query: 784 MKQCWAEQPELRPS 797
MK CW +RPS
Sbjct: 419 MKNCWHLDAAMRPS 432
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 78.2 bits (191), Expect = 4e-14
Identities = 74/254 (29%), Positives = 114/254 (44%), Gaps = 40/254 (15%)
Query: 552 IGVYEGDRVWLKKFPGDQHIAIRPATKTAF----SKLQELRHENVALYLGLFLARGAEGP 607
+G Y G++V +K D AT AF S + +LRH N+ LG+ +
Sbjct: 211 LGDYRGNKVAVKCIKND-------ATAQAFLAEASVMTQLRHSNLVQLLGVIVEE----- 258
Query: 608 AALWEGNLAVVSEHCTRGSLQDLLAQREIKL---DWMFKSSLLLDLIKGIRYLHHRGVAH 664
+G L +V+E+ +GSL D L R + D + K SL D+ + + YL H
Sbjct: 259 ----KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL--DVCEAMEYLEGNNFVH 312
Query: 665 GRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALERRGT 724
L +RN +V V K++D G + + + + P WTAPE LR E++ +
Sbjct: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLP----VKWTAPEALR----EKKFS 364
Query: 725 LAGDVFSLAIIMQEVVC-RSAPYAMLELTPEEVVQRVRSPPPLCRPLVSMDQAPVECILL 783
DV+S I++ E+ PY + L ++VV RV + P D P +
Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPL--KDVVPRVEKGYKMDAP----DGCPPAVYEV 418
Query: 784 MKQCWAEQPELRPS 797
MK CW +RPS
Sbjct: 419 MKNCWHLDAAMRPS 432
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 78.2 bits (191), Expect = 4e-14
Identities = 73/257 (28%), Positives = 112/257 (43%), Gaps = 42/257 (16%)
Query: 560 VWLKKFPGDQHIAIR---PATKTAFSKLQE------LRHEN-VALYLGLFLARGAEGPAA 609
VWL + G+ +AI+ P T + S L+E L+H+ V LY A
Sbjct: 282 VWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY------------AV 329
Query: 610 LWEGNLAVVSEHCTRGSLQDLLAQ---REIKLDWMFKSSLLLDLIKGIRYLHHRGVAHGR 666
+ E + +V+E+ +GSL D L R +KL + + + G+ Y+ H
Sbjct: 330 VSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLV--DMAAQVAAGMAYIERMNYIHRD 387
Query: 667 LKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALERRGTLA 726
L+S N +V + KI D G RL+E + WTAPE AL R T+
Sbjct: 388 LRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPE----AALYGRFTIK 443
Query: 727 GDVFSLAIIMQEVVCRS-APYAMLELTP--EEVVQRVRSPPPLCRPLVSMDQAPVECILL 783
DV+S I++ E+V + PY + E+V + R P P P+ L
Sbjct: 444 SDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCP--------QDCPISLHEL 495
Query: 784 MKQCWAEQPELRPSMDH 800
M CW + PE RP+ ++
Sbjct: 496 MIHCWKKDPEERPTFEY 512
>gi|66932999 testis-specific protein kinase 1 [Homo sapiens]
Length = 626
Score = 78.2 bits (191), Expect = 4e-14
Identities = 66/221 (29%), Positives = 100/221 (45%), Gaps = 32/221 (14%)
Query: 584 LQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFK 643
+ LRH N+ ++G+ + +G L ++E+ G+L+ LL+ E L W +
Sbjct: 104 MNRLRHPNILRFMGV----------CVHQGQLHALTEYMNGGTLEQLLSSPE-PLSWPVR 152
Query: 644 SSLLLDLIKGIRYLHHRGVAHGRLKSRNCIV---DGRFVLKITDHGHGRLLEAQKVLPEP 700
L LD+ +G+RYLH +GV H L S+NC+V D F + D G L E V E
Sbjct: 153 LHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFG---LAEKIPVYREG 209
Query: 701 PRAE------DQLWTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPYAMLELTPE 754
R E W APE+LR + + DVF+ I++ E++ R A + P
Sbjct: 210 ARKEPLAVVGSPYWMAPEVLRGELYDEK----ADVFAFGIVLCELIARVP--ADPDYLPR 263
Query: 755 EVVQRVRSPPPLCRPLVSMDQAPVECILLMKQCWAEQPELR 795
+ P R LV D P+ +LL C +P R
Sbjct: 264 --TEDFGLDVPAFRTLVG-DDCPLPFLLLAIHCCNLEPSTR 301
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,231,875
Number of Sequences: 37866
Number of extensions: 2308780
Number of successful extensions: 7978
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 302
Number of HSP's successfully gapped in prelim test: 350
Number of HSP's that attempted gapping in prelim test: 7118
Number of HSP's gapped (non-prelim): 852
length of query: 1103
length of database: 18,247,518
effective HSP length: 113
effective length of query: 990
effective length of database: 13,968,660
effective search space: 13828973400
effective search space used: 13828973400
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.