Search of human proteins with 4502861

Search of human proteins with 4502861

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4502861 adaptor-related protein complex 3, sigma 1 subunit
[Homo sapiens]
         (193 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4502861 adaptor-related protein complex 3, sigma 1 subunit [H...   386   e-108
gi|5031581 adaptor-related protein complex 3, sigma 2 subunit [H...   333   5e-92
gi|70906430 adaptor-related protein complex 2, sigma 1 subunit i...   114   7e-26
gi|4557471 adaptor-related protein complex 1, sigma 1 subunit [H...   108   3e-24
gi|22027655 adaptor-related protein complex 1 sigma 2 subunit [H...   107   6e-24
gi|189409104 adaptor-related protein complex 4, sigma 1 subunit ...   104   5e-23
gi|88703051 adaptor-related protein complex 1, sigma 3 subunit [...   101   5e-22
gi|21361394 adaptor-related protein complex 4, sigma 1 subunit i...    73   1e-13
gi|11038643 adaptor-related protein complex 2, sigma 1 subunit i...    67   9e-12
gi|7705983 coatomer protein complex, subunit zeta 2 [Homo sapiens]     54   6e-08
gi|7706337 coatomer protein complex, subunit zeta 1 [Homo sapiens]     47   1e-05
gi|197209857 adaptor-related protein complex 3, mu 2 subunit [Ho...    30   1.3  
gi|5803000 adaptor-related protein complex 3, mu 2 subunit [Homo...    30   1.3  
gi|4557485 ceruloplasmin precursor [Homo sapiens]                      28   3.7  
gi|121114302 cullin 4B isoform 2 [Homo sapiens]                        28   6.3  
gi|121114298 cullin 4B isoform 1 [Homo sapiens]                        28   6.3  

>gi|4502861 adaptor-related protein complex 3, sigma 1 subunit [Homo
           sapiens]
          Length = 193

 Score =  386 bits (992), Expect = e-108
 Identities = 193/193 (100%), Positives = 193/193 (100%)

Query: 1   MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 60
           MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
Sbjct: 1   MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 60

Query: 61  NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL 120
           NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL
Sbjct: 61  NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL 120

Query: 121 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG 180
           AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG
Sbjct: 121 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG 180

Query: 181 DISIKVPNLPSFK 193
           DISIKVPNLPSFK
Sbjct: 181 DISIKVPNLPSFK 193


>gi|5031581 adaptor-related protein complex 3, sigma 2 subunit [Homo
           sapiens]
          Length = 193

 Score =  333 bits (854), Expect = 5e-92
 Identities = 162/192 (84%), Positives = 178/192 (92%)

Query: 1   MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 60
           MI+AIL+FNNHGKPRL +FYQ + E+ QQQI+RETFHLV KRD+N+CNFLEGG LIGGSD
Sbjct: 1   MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSD 60

Query: 61  NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL 120
            KLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFH+DKVH IL
Sbjct: 61  YKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYIL 120

Query: 121 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG 180
            E+VMGGMVLETNMNEIV QI+AQN+LEKSE GL+ APARAVSAVKN+NLPEIPRNINIG
Sbjct: 121 QEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIG 180

Query: 181 DISIKVPNLPSF 192
           D++IKVPNL  F
Sbjct: 181 DLNIKVPNLSQF 192


>gi|70906430 adaptor-related protein complex 2, sigma 1 subunit
           isoform AP17 [Homo sapiens]
          Length = 142

 Score =  114 bits (284), Expect = 7e-26
 Identities = 60/148 (40%), Positives = 91/148 (61%), Gaps = 6/148 (4%)

Query: 1   MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 60
           MI+ ILI N  GK RL+K+Y  + +D +Q++I E   +V+ RD    NF+E        +
Sbjct: 1   MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEF------RN 54

Query: 61  NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL 120
            K+IYR YA LYF  CVD +++ L  L+ I  FVE L++ F NVCELDL+F+  KV+ ++
Sbjct: 55  FKIIYRRYAGLYFCICVDVNDNNLAYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYTVV 114

Query: 121 AEMVMGGMVLETNMNEIVTQIDAQNKLE 148
            EM + G + ET+  +++ Q+     LE
Sbjct: 115 DEMFLAGEIRETSQTKVLKQLLMLQSLE 142


>gi|4557471 adaptor-related protein complex 1, sigma 1 subunit [Homo
           sapiens]
          Length = 158

 Score =  108 bits (270), Expect = 3e-24
 Identities = 55/151 (36%), Positives = 95/151 (62%), Gaps = 6/151 (3%)

Query: 1   MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 60
           M++ +L+F+  GK RL K+Y   S+  +++++RE   +V  R   +C+FLE        D
Sbjct: 1   MMRFMLLFSRQGKLRLQKWYLATSDKERKKMVRELMQVVLARKPKMCSFLEW------RD 54

Query: 61  NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL 120
            K++Y+ YA+LYF   ++  ++EL  L+LI  +VE LDK F +VCELD+IF+ +K + IL
Sbjct: 55  LKVVYKRYASLYFCCAIEGQDNELITLELIHRYVELLDKYFGSVCELDIIFNFEKAYFIL 114

Query: 121 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSE 151
            E +MGG V +T+   ++  I+  + L++ +
Sbjct: 115 DEFLMGGDVQDTSKKSVLKAIEQADLLQEED 145


>gi|22027655 adaptor-related protein complex 1 sigma 2 subunit [Homo
           sapiens]
          Length = 157

 Score =  107 bits (267), Expect = 6e-24
 Identities = 55/145 (37%), Positives = 90/145 (62%), Gaps = 6/145 (4%)

Query: 5   ILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLI 64
           +L+F+  GK RL K+Y P S+  +++I RE    V  R   +C+FLE        D K++
Sbjct: 4   MLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEW------RDLKIV 57

Query: 65  YRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMV 124
           Y+ YA+LYF   ++  ++EL  L++I  +VE LDK F +VCELD+IF+ +K + IL E +
Sbjct: 58  YKRYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFL 117

Query: 125 MGGMVLETNMNEIVTQIDAQNKLEK 149
           +GG V ET+   ++  I+  + L++
Sbjct: 118 LGGEVQETSKKNVLKAIEQADLLQE 142


>gi|189409104 adaptor-related protein complex 4, sigma 1 subunit
           isoform 2 [Homo sapiens]
          Length = 144

 Score =  104 bits (259), Expect = 5e-23
 Identities = 58/150 (38%), Positives = 86/150 (57%), Gaps = 6/150 (4%)

Query: 1   MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 60
           MIK  L+ N  G+ RLSK+Y+    + +  +  E       R    C+F+E        D
Sbjct: 1   MIKFFLMVNKQGQTRLSKYYEHVDINKRTLLETEVIKSCLSRSNEQCSFIEY------KD 54

Query: 61  NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL 120
            KLIYR YA L+ V  V+ +E+E+ I + I  FVE LD+ F  V ELD++F++DKVH IL
Sbjct: 55  FKLIYRQYAALFIVVGVNDTENEMAIYEFIHNFVEVLDEYFSRVSELDIMFNLDKVHIIL 114

Query: 121 AEMVMGGMVLETNMNEIVTQIDAQNKLEKS 150
            EMV+ G ++ETN   I+  +   +K+ +S
Sbjct: 115 DEMVLNGCIVETNRARILAPLLILDKMSES 144


>gi|88703051 adaptor-related protein complex 1, sigma 3 subunit
           [Homo sapiens]
          Length = 154

 Score =  101 bits (251), Expect = 5e-22
 Identities = 53/150 (35%), Positives = 90/150 (60%), Gaps = 6/150 (4%)

Query: 1   MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 60
           MI  IL+F+  GK RL K+Y    +  +++I RE   ++  R     +F++   L     
Sbjct: 1   MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKEL----- 55

Query: 61  NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL 120
            KL+Y+ YA+LYF   +++ ++EL  L+++  +VE LDK F NVCELD+IF+ +K + IL
Sbjct: 56  -KLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFIL 114

Query: 121 AEMVMGGMVLETNMNEIVTQIDAQNKLEKS 150
            E ++GG + ET+    V  I+  + L+++
Sbjct: 115 DEFIIGGEIQETSKKIAVKAIEDSDMLQET 144


>gi|21361394 adaptor-related protein complex 4, sigma 1 subunit
           isoform 1 [Homo sapiens]
          Length = 159

 Score = 73.2 bits (178), Expect = 1e-13
 Identities = 43/118 (36%), Positives = 61/118 (51%), Gaps = 6/118 (5%)

Query: 1   MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 60
           MIK  L+ N  G+ RLSK+Y+    + +  +  E       R    C+F+E        D
Sbjct: 1   MIKFFLMVNKQGQTRLSKYYEHVDINKRTLLETEVIKSCLSRSNEQCSFIEY------KD 54

Query: 61  NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHN 118
            KLIYR YA L+ V  V+ +E+E+ I + I  FVE LD+ F  V ELD+ F     H+
Sbjct: 55  FKLIYRQYAALFIVVGVNDTENEMAIYEFIHNFVEVLDEYFSRVSELDVSFFNTVFHS 112


>gi|11038643 adaptor-related protein complex 2, sigma 1 subunit
           isoform AP17delta [Homo sapiens]
          Length = 104

 Score = 67.0 bits (162), Expect = 9e-12
 Identities = 43/148 (29%), Positives = 67/148 (45%), Gaps = 44/148 (29%)

Query: 1   MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 60
           MI+ ILI N  GK RL+K+Y  + +D +Q++I E   +V+ RD    NF           
Sbjct: 1   MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNF----------- 49

Query: 61  NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL 120
                                            VE L++ F NVCELDL+F+  KV+ ++
Sbjct: 50  ---------------------------------VEVLNEYFHNVCELDLVFNFYKVYTVV 76

Query: 121 AEMVMGGMVLETNMNEIVTQIDAQNKLE 148
            EM + G + ET+  +++ Q+     LE
Sbjct: 77  DEMFLAGEIRETSQTKVLKQLLMLQSLE 104


>gi|7705983 coatomer protein complex, subunit zeta 2 [Homo sapiens]
          Length = 210

 Score = 54.3 bits (129), Expect = 6e-08
 Identities = 35/144 (24%), Positives = 78/144 (54%), Gaps = 12/144 (8%)

Query: 2   IKAILIFNNHGKPRLSKFYQPYSEDTQQQII--RETFHLVSKRDENVCNFLEGGLLIGGS 59
           IKA+ I +N G+  L+K+Y       ++Q++  +  F+  S+ +  +  F  GG+ I   
Sbjct: 46  IKAVFILDNDGRRLLAKYYDDTFPSMKEQMVFEKNVFNKTSRTESEIAFF--GGMTI--- 100

Query: 60  DNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCF-ENVCELDLIFHVDKVHN 118
               +Y++   L+      S E+EL ++ ++    E+L+    +NV +  L+ ++D    
Sbjct: 101 ----VYKNSIDLFLYVVGSSYENELMLMSVLTCLFESLNHMLRKNVEKRWLLENMDGAFL 156

Query: 119 ILAEMVMGGMVLETNMNEIVTQID 142
           +L E+V GG++LE++  +++ +++
Sbjct: 157 VLDEIVDGGVILESDPQQVIQKVN 180


>gi|7706337 coatomer protein complex, subunit zeta 1 [Homo sapiens]
          Length = 177

 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 34/142 (23%), Positives = 72/142 (50%), Gaps = 10/142 (7%)

Query: 2   IKAILIFNNHGKPRLSKFY-QPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD 60
           +KAILI +N G    +K+Y   Y    +Q+   +     + R ++    LEG        
Sbjct: 13  VKAILILDNDGDRLFAKYYDDTYPSVKEQKAFEKNIFNKTHRTDSEIALLEG-------- 64

Query: 61  NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCF-ENVCELDLIFHVDKVHNI 119
             ++Y+    LYF     S E+EL ++ ++    ++L +   +NV +  L+ +++ +   
Sbjct: 65  LTVVYKSSIDLYFYVIGSSYENELMLMAVLNCLFDSLSQMLRKNVEKRALLENMEGLFLA 124

Query: 120 LAEMVMGGMVLETNMNEIVTQI 141
           + E+V GG++LE++  ++V ++
Sbjct: 125 VDEIVDGGVILESDPQQVVHRV 146


>gi|197209857 adaptor-related protein complex 3, mu 2 subunit [Homo
           sapiens]
          Length = 418

 Score = 30.0 bits (66), Expect = 1.3
 Identities = 19/72 (26%), Positives = 34/72 (47%), Gaps = 2/72 (2%)

Query: 64  IYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEM 123
           +YRH   ++FV  + +    L +++ +   V+T    F    E  +  +V  V+ +L EM
Sbjct: 59  VYRH--KIFFVAVIQTEVPPLFVIEFLHRVVDTFQDYFGVCSEPVIKDNVVVVYEVLEEM 116

Query: 124 VMGGMVLETNMN 135
           +  G  L T  N
Sbjct: 117 LDNGFPLATESN 128


>gi|5803000 adaptor-related protein complex 3, mu 2 subunit [Homo
           sapiens]
          Length = 418

 Score = 30.0 bits (66), Expect = 1.3
 Identities = 19/72 (26%), Positives = 34/72 (47%), Gaps = 2/72 (2%)

Query: 64  IYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEM 123
           +YRH   ++FV  + +    L +++ +   V+T    F    E  +  +V  V+ +L EM
Sbjct: 59  VYRH--KIFFVAVIQTEVPPLFVIEFLHRVVDTFQDYFGVCSEPVIKDNVVVVYEVLEEM 116

Query: 124 VMGGMVLETNMN 135
           +  G  L T  N
Sbjct: 117 LDNGFPLATESN 128


>gi|4557485 ceruloplasmin precursor [Homo sapiens]
          Length = 1065

 Score = 28.5 bits (62), Expect = 3.7
 Identities = 23/64 (35%), Positives = 34/64 (53%), Gaps = 7/64 (10%)

Query: 28  QQQIIRETFHLVSKRDENVCN-FLEGG-LLIGGSDNKLIYRHYATLYFVFCVD--SSESE 83
           Q++  +E  HL   +++NV N FL+ G   IG    K++YR Y    F   V+  + E  
Sbjct: 748 QREWEKELHHL---QEQNVSNAFLDKGEFYIGSKYKKVVYRQYTDSTFRVPVERKAEEEH 804

Query: 84  LGIL 87
           LGIL
Sbjct: 805 LGIL 808



 Score = 28.1 bits (61), Expect = 4.8
 Identities = 18/53 (33%), Positives = 25/53 (47%), Gaps = 2/53 (3%)

Query: 37  HLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVD--SSESELGIL 87
           +L +   ++   F +G   IGGS  KL+YR Y    F    +    E  LGIL
Sbjct: 397 NLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHLGIL 449


>gi|121114302 cullin 4B isoform 2 [Homo sapiens]
          Length = 895

 Score = 27.7 bits (60), Expect = 6.3
 Identities = 36/159 (22%), Positives = 70/159 (44%), Gaps = 23/159 (14%)

Query: 3   KAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNK 62
           K ++I N   KP+L    + Y+++T Q++ +E    +        N  E   L    +N 
Sbjct: 177 KKLVIKNFKDKPKLP---ENYTDETWQKL-KEAVEAIQNSTSIKYNLEE---LYQAVENL 229

Query: 63  LIYRHYATLYFVF---CVDSSESEL-----GILDLIQVFVETLDKCFENVCE-----LDL 109
             Y+  A LY      C D  ++++       LD + +F++ +D+C++N C        +
Sbjct: 230 CSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSV-LFLKKIDRCWQNHCRQMIMIRSI 288

Query: 110 IFHVDKVHNILAEMV--MGGMVLETNMNEIVTQIDAQNK 146
              +D+ + +   M+  +  M LE     I++    QNK
Sbjct: 289 FLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNK 327


>gi|121114298 cullin 4B isoform 1 [Homo sapiens]
          Length = 913

 Score = 27.7 bits (60), Expect = 6.3
 Identities = 36/159 (22%), Positives = 70/159 (44%), Gaps = 23/159 (14%)

Query: 3   KAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNK 62
           K ++I N   KP+L    + Y+++T Q++ +E    +        N  E   L    +N 
Sbjct: 195 KKLVIKNFKDKPKLP---ENYTDETWQKL-KEAVEAIQNSTSIKYNLEE---LYQAVENL 247

Query: 63  LIYRHYATLYFVF---CVDSSESEL-----GILDLIQVFVETLDKCFENVCE-----LDL 109
             Y+  A LY      C D  ++++       LD + +F++ +D+C++N C        +
Sbjct: 248 CSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSV-LFLKKIDRCWQNHCRQMIMIRSI 306

Query: 110 IFHVDKVHNILAEMV--MGGMVLETNMNEIVTQIDAQNK 146
              +D+ + +   M+  +  M LE     I++    QNK
Sbjct: 307 FLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNK 345


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.139    0.398 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 6,585,466
Number of Sequences: 37866
Number of extensions: 257445
Number of successful extensions: 653
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 632
Number of HSP's gapped (non-prelim): 18
length of query: 193
length of database: 18,247,518
effective HSP length: 97
effective length of query: 96
effective length of database: 14,574,516
effective search space: 1399153536
effective search space used: 1399153536
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.