Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 42741669
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42741669 kelch repeat and BTB (POZ) domain containing 10
[Homo sapiens]
(606 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Hom... 1212 0.0
gi|45593142 kelch repeat and BTB (POZ) domain containing 5 [Homo... 663 0.0
gi|227497736 T-cell activation kelch repeat protein [Homo sapiens] 224 2e-58
gi|40807500 kelch-like 20 [Homo sapiens] 224 2e-58
gi|55925604 kelch-like 18 [Homo sapiens] 223 4e-58
gi|38194229 kelch-like 17 [Homo sapiens] 216 4e-56
gi|11056006 kelch-like 12 [Homo sapiens] 213 4e-55
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 210 3e-54
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 208 1e-53
gi|166235129 kelch-like 3 [Homo sapiens] 202 7e-52
gi|40018614 DRE1 protein [Homo sapiens] 199 5e-51
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 199 5e-51
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 198 1e-50
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 197 2e-50
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 197 2e-50
gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Hom... 197 3e-50
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 197 3e-50
gi|148664209 kelch-like 10 [Homo sapiens] 194 2e-49
gi|14780904 kelch-like 1 protein [Homo sapiens] 194 2e-49
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 193 4e-49
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 193 4e-49
gi|109150407 kelch-like 6 [Homo sapiens] 189 8e-48
gi|34101268 kelch-like 8 [Homo sapiens] 186 7e-47
gi|148664248 kelch domain containing 6 [Homo sapiens] 185 9e-47
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 184 2e-46
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 184 2e-46
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 181 1e-45
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 181 1e-45
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 179 5e-45
gi|223890235 intracisternal A particle-promoted polypeptide isof... 179 5e-45
>gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Homo
sapiens]
Length = 606
Score = 1212 bits (3136), Expect = 0.0
Identities = 606/606 (100%), Positives = 606/606 (100%)
Query: 1 MDSQRELAEELRLYQSTLLQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFRE 60
MDSQRELAEELRLYQSTLLQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFRE
Sbjct: 1 MDSQRELAEELRLYQSTLLQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFRE 60
Query: 61 YFLSEIDEAKKKEVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFT 120
YFLSEIDEAKKKEVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFT
Sbjct: 61 YFLSEIDEAKKKEVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFT 120
Query: 121 VCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELI 180
VCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELI
Sbjct: 121 VCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELI 180
Query: 181 SVISNDSLNVEKEEAVFEAVMKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDD 240
SVISNDSLNVEKEEAVFEAVMKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDD
Sbjct: 181 SVISNDSLNVEKEEAVFEAVMKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDD 240
Query: 241 IIKSNPDLQKKIKVLKDAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGM 300
IIKSNPDLQKKIKVLKDAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGM
Sbjct: 241 IIKSNPDLQKKIKVLKDAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGM 300
Query: 301 FVKDLILLVNDTAAVAYDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENK 360
FVKDLILLVNDTAAVAYDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENK
Sbjct: 301 FVKDLILLVNDTAAVAYDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENK 360
Query: 361 DQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCY 420
DQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCY
Sbjct: 361 DQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCY 420
Query: 421 DPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAP 480
DPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAP
Sbjct: 421 DPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAP 480
Query: 481 MKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSL 540
MKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSL
Sbjct: 481 MKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSL 540
Query: 541 AGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRLNL 600
AGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRLNL
Sbjct: 541 AGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRLNL 600
Query: 601 FKLSKL 606
FKLSKL
Sbjct: 601 FKLSKL 606
>gi|45593142 kelch repeat and BTB (POZ) domain containing 5 [Homo
sapiens]
Length = 621
Score = 663 bits (1710), Expect = 0.0
Identities = 313/618 (50%), Positives = 444/618 (71%), Gaps = 19/618 (3%)
Query: 6 ELAEELRLYQSTLLQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSE 65
E AEE RLYQ TLLQDGLKD+LD KF+DC ++AG++ PCHRL+L+ACSPYFR FL+E
Sbjct: 6 EQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAE 65
Query: 66 IDEAKKKEVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSY 125
+ A E+ L+ V P ++ ++ YLY++ I L++ +VQD+FA A RFQIPS+FT+CVS+
Sbjct: 66 PERAG--ELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSF 123
Query: 126 LQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISN 185
LQKRL NCLA+ RLGLLLDC RLA++AR+F+ F + ++ DF+ LS ELI++IS+
Sbjct: 124 LQKRLCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISS 183
Query: 186 DSLNVEKEEAVFEAVMKWVRTD----KENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDI 241
D LNVEKEEAVFEAVM+W + + R + L VF+ +R RL+ + + VE+ +
Sbjct: 184 DGLNVEKEEAVFEAVMRWAGSGDAEAQAERQRALPTVFESVRCRLLPRAFLESRVERHPL 243
Query: 242 IKSNPDLQKKIKVLKDAFAGKLPE-PSKNAAKTGAGEVNGDVGD-----------EDLLP 289
+++ P+L +K++++KDA G++ K K GAG D G E +LP
Sbjct: 244 VRAQPELLRKVQMVKDAHEGRITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILP 303
Query: 290 GYLNDIPRHGMFVKDLILLVNDTAAVAYDPTENECYLTALAEQIPRNHSSIVTQQNQIYV 349
G LND R GMF++DLI ++++ AVAYDP NECY +L+ Q+P+NH S+VT++NQ++V
Sbjct: 304 GILNDTLRFGMFLQDLIFMISEEGAVAYDPAANECYCASLSNQVPKNHVSLVTKENQVFV 363
Query: 350 VGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQ 409
GGL+ +E+NK+ P+ +YF Q D + SEW+G+PPLPS RCLFGLGE + IYVV G++++
Sbjct: 364 AGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGREIK 423
Query: 410 T-EASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIF 468
E LDSV+CYD ++ KW E LP VYGH V+SH ++Y +GGK D+KC N++ ++
Sbjct: 424 DGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDRKCLNKMCVY 483
Query: 469 NPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEF 528
+PKK +WK+LAPM+ RS+FG VH G+I++A GVT+ GL++S E + +T NKW F
Sbjct: 484 DPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAF 543
Query: 529 PQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYA 588
PQERSS+SLVSL G+LYAIGGFA ++ ES E PTE+NDIW+Y +++K+W G+L+EI YA
Sbjct: 544 PQERSSLSLVSLVGTLYAIGGFATLETESGELVPTELNDIWRYNEEEKKWEGVLREIAYA 603
Query: 589 SGASCLATRLNLFKLSKL 606
+GA+ L RLN+ L+K+
Sbjct: 604 AGATFLPVRLNVLCLTKM 621
>gi|227497736 T-cell activation kelch repeat protein [Homo sapiens]
Length = 601
Score = 224 bits (571), Expect = 2e-58
Identities = 158/574 (27%), Positives = 259/574 (45%), Gaps = 62/574 (10%)
Query: 23 LKDLLDEKKFIDCTLKAGD-KSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDP 81
LK + DE + D ++ K+ CHR +L+A SPYFR F S + E+ +KEV + V+
Sbjct: 39 LKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEA 98
Query: 82 AILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRL 141
+DL++ Y Y++ + L + NVQ +F AS FQIPS+ C Y+ L P N + +
Sbjct: 99 ESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIF 158
Query: 142 GLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVM 201
L ++E++ +F+ + KE++F+QL+ +LIS++ +D LNV++EE V+E+++
Sbjct: 159 ADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESII 218
Query: 202 KWVRTDKENRVKNLSEVF-DCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFA 260
+W ++ R +L E+F CIRF LM + + I K P + I
Sbjct: 219 RWFEHEQNEREVHLPEIFAKCIRFPLMEDTF---------IEKIPPQFAQAI-------- 261
Query: 261 GKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVN--------DT 312
+K+ + G NG R GM ++I+ +
Sbjct: 262 ------AKSCVEKGPSNTNGCT-------------QRLGMTASEMIICFDAAHKHSGKKQ 302
Query: 313 AAVAYDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGL--YVDEENKDQPLQSYFFQ 370
D + R +V+ N IY+ GG E + D ++ F+
Sbjct: 303 TVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWM 362
Query: 371 LDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEA--SLDSVLCYDPVAAKWN 428
D + W+ P L AR L K+Y + G+ + + SL SV CYD W
Sbjct: 363 YDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWT 422
Query: 429 EVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMF 488
V +P+ + HN + +K IY L G+ + P+K W L PM +PR
Sbjct: 423 TVCAMPVAMEFHNAVEYKEKIYVLQGEF--------FLFYEPQKDYWGFLTPMTVPRIQG 474
Query: 489 GVAVHKGKI-VIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERS---SISLVSLAGSL 544
AV+K I IAG +VEA+D+ NKW +FP ++S + LV L
Sbjct: 475 LAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKL 534
Query: 545 YAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEW 578
+ + +E F + N +++Y+D +W
Sbjct: 535 HLFVRATQVTVEEHVFRTSRKNSLYQYDDIADQW 568
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 224 bits (571), Expect = 2e-58
Identities = 156/532 (29%), Positives = 244/532 (45%), Gaps = 37/532 (6%)
Query: 26 LLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPAILD 85
L ++ D L G K + HR+ILSACSPYFR F E+ E+++ EVV+ ++D ++
Sbjct: 61 LRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAME 120
Query: 86 LIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLL 145
L+I + Y++ I + +GNVQ + A Q+ + C +L+++L P NCL I
Sbjct: 121 LLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTH 180
Query: 146 DCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVR 205
C L A +F F ++ + E+FM L +LI +IS+D LNV EE VF AVM WV+
Sbjct: 181 SCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVK 240
Query: 206 TDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGKLPE 265
+ R L +V +R L++ K+ V D +IKS+ + + + K+
Sbjct: 241 YSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQER 300
Query: 266 PSKNAAKT------GAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDP 319
P +T GEV VG G D I ++ YDP
Sbjct: 301 PLMQGPRTRPRKPIRCGEVLFAVG---------------GWCSGDAI-----SSVERYDP 340
Query: 320 TENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWV 379
NE + A + R + + +Y VGG D + ++ Y D ++W
Sbjct: 341 QTNEWRMVASMSK-RRCGVGVSVLDDLLYAVGG--HDGSSYLNSVERY----DPKTNQWS 393
Query: 380 G-LPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVY 438
+ P + R G+ + +Y V G+D + L+ V YDP KW V + +
Sbjct: 394 SDVAPTSTCRTSVGVAVLGGFLYAVGGQD--GVSCLNIVERYDPKENKWTRVASMSTRRL 451
Query: 439 GHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIV 498
G V G +Y +GG +D N V +NP++ W +APM R G AV++ I
Sbjct: 452 GVAVAVLGGFLYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIY 510
Query: 499 IAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGF 550
GG + +S E ++ TN+W + RS + L + G L A+GGF
Sbjct: 511 AVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGF 562
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 223 bits (568), Expect = 4e-58
Identities = 158/582 (27%), Positives = 257/582 (44%), Gaps = 44/582 (7%)
Query: 2 DSQRELAEELRLYQSTLLQDG---LKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYF 58
D EL + + S L G ++++ + K D TLK GD HR++L+A PYF
Sbjct: 4 DGAEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYF 63
Query: 59 REYFLSEIDEAKKKEVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSV 118
F +++ E K+ E+V+ +DP+ L+ +I + Y+ ++ ++ NVQ + AS Q+ S+
Sbjct: 64 HAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSI 123
Query: 119 FTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQE 178
C ++L++RL P NCL + + + C L +A F+ FV++ E+F+ L ++
Sbjct: 124 KDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLED 183
Query: 179 LISVISNDSLNVEKEEAVFEAVMKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEK 238
++ ++S D LNV+ EE VFEA + WVR D+E R L E+ IR L ++ D V++
Sbjct: 184 VLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQ 243
Query: 239 DDIIKSNPDLQKKIKVLKDAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRH 298
DD+++ + + KD P A +T PR
Sbjct: 244 DDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTR---------------------PRC 282
Query: 299 GMFVKDLILLVND--------TAAVAYDPTENECYLTALAEQIPRNHSSIVTQQNQIYVV 350
+ LI V +DP N C+ R+ + +Y +
Sbjct: 283 CTSIAGLIYAVGGLNSAGDSLNVVEVFDPIAN-CWERCRPMTTARSRVGVAVVNGLLYAI 341
Query: 351 GGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQT 410
GG D + + +++Y + D+ W + + S R G +D +IYV G D
Sbjct: 342 GG--YDGQLRLSTVEAYNPETDT----WTRVGSMNSKRSAMGTVVLDGQIYVCGGYD--G 393
Query: 411 EASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNP 470
+SL SV Y P KW V + V +G IY GG D + + V +N
Sbjct: 394 NSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGH-DGLQIFSSVEHYNH 452
Query: 471 KKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQ 530
W A M R G A K+ + GG G + E + ++W ++
Sbjct: 453 HTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHT 512
Query: 531 ERSSISLVSLAGSLYAIGGF-AMIQLESKEFAPTEVNDIWKY 571
RS +SLV+ G LYA+GG+ L S E E D W +
Sbjct: 513 RRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPE-TDCWTF 553
Score = 75.9 bits (185), Expect = 1e-13
Identities = 56/202 (27%), Positives = 89/202 (44%), Gaps = 15/202 (7%)
Query: 400 IYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDK 459
IY V G + + SL+ V +DP+A W + + V G++Y +GG D +
Sbjct: 290 IYAVGGLNSAGD-SLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGY-DGQ 347
Query: 460 KCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTT 519
+ V +NP+ W + M RS G V G+I + GG + +SVE + T
Sbjct: 348 LRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPET 407
Query: 520 NKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEW- 578
+KW V+T RS+ + G +Y GG +Q+ S + Y W
Sbjct: 408 DKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFS---------SVEHYNHHTATWH 458
Query: 579 --AGMLKEIRYASGASCLATRL 598
AGML + R GA+ L +++
Sbjct: 459 PAAGMLNK-RCRHGAASLGSKM 479
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 216 bits (551), Expect = 4e-56
Identities = 157/572 (27%), Positives = 257/572 (44%), Gaps = 59/572 (10%)
Query: 34 DCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPAILDLIIKYLYS 93
D L K + H+++L++CSPYF F +E+ E+++ V L ++DP LD ++++ Y+
Sbjct: 93 DIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYT 152
Query: 94 ASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAIS 153
A I + +GNVQ + AS Q+ V C +L +L P NCL I C L +
Sbjct: 153 AEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADAHSCSDLLKA 212
Query: 154 AREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVRTDKENRVK 213
A +V FV + K E+FM L ++++ ++S+DSLNV EE V+ AV+ WV+ D + R +
Sbjct: 213 AHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLSWVKHDVDARRQ 272
Query: 214 NLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQK------KIKVLKDAFAGKLPEPS 267
++ + C+R L++ + HV+ + +++ +PD + K +L + +
Sbjct: 273 HVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRT 332
Query: 268 KNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPTENECYLT 327
+ GAG V VG L HG AYD + ++
Sbjct: 333 RPRRCEGAGPVLFAVGGGSL-------FAIHG-------------DCEAYDTRTDRWHVV 372
Query: 328 ALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSA 387
A + R + N++Y VGG D + ++SY D + + W + +
Sbjct: 373 A-SMSTRRARVGVAAVGNRLYAVGG--YDGTSDLATVESY----DPVTNTWQPEVSMGTR 425
Query: 388 RCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKG 447
R G+ + +Y G D + L+S YDP+ W V + + V + G
Sbjct: 426 RSCLGVAALHGLLYSAGGYD--GASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDG 483
Query: 448 MIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDG 507
+Y +GG D V + P+ W +A M RS GVAV +G + +AGG DG
Sbjct: 484 NLYAVGG-YDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGG--NDG 540
Query: 508 LSA--SVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEV 565
S SVE + W+ + RS+ LV++ G LYA+GG + +
Sbjct: 541 TSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGG---------NDGSSSL 591
Query: 566 NDIWKYEDDKKEWAGMLKEIRYASGASCLATR 597
N I KY +W ASC+ TR
Sbjct: 592 NSIEKYNPRTNKWV----------AASCMFTR 613
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 213 bits (542), Expect = 4e-55
Identities = 151/556 (27%), Positives = 257/556 (46%), Gaps = 34/556 (6%)
Query: 21 DGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVD 80
+ + L D TL+ K P HR++L+ACS YF F SE+ E K V + +
Sbjct: 21 NSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLT 80
Query: 81 PAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILR 140
+ +++++ ++Y+ ++ + NVQ++ A Q+ V C +L+ +L P NCL I
Sbjct: 81 ASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRD 140
Query: 141 LGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAV 200
+C L +A F F ++ + E+F+ LS E+ +I D + V+ EE VFEAV
Sbjct: 141 FAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAV 200
Query: 201 MKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSN---PDLQKKIKV--L 255
+ WV+ K+ R ++L + +R L+T +Y D ++ + I+ + DL + K L
Sbjct: 201 INWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHL 260
Query: 256 KDAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAV 315
+ ++ P + A+ GA EV VG ++ + +
Sbjct: 261 RPELRSQMQGP-RTRARLGANEVLLVVGGFGSQQSPIDVVEK------------------ 301
Query: 316 AYDP-TENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSI 374
YDP T+ +L ++ + R + + V+ ++IYV+GG D ++ ++ + D
Sbjct: 302 -YDPKTQEWSFLPSITRK--RRYVASVSLHDRIYVIGG--YDGRSRLSSVECLDYTADE- 355
Query: 375 ASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLP 434
W + P+ R L G + D IYV G D + S+ YDP +W+ + +
Sbjct: 356 DGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHT--SMERYDPNIDQWSMLGDMQ 413
Query: 435 IKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHK 494
G ++ G+IYCLGG D N V ++P G W ++ PM RS GVA+
Sbjct: 414 TAREGAGLVVASGVIYCLGG-YDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLN 472
Query: 495 GKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQ 554
I + GG +SVEA+++ T+ W +T R + L G LYAI G+
Sbjct: 473 DHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNS 532
Query: 555 LESKEFAPTEVNDIWK 570
L S + D W+
Sbjct: 533 LLSSIECYDPIIDSWE 548
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 210 bits (535), Expect = 3e-54
Identities = 149/575 (25%), Positives = 255/575 (44%), Gaps = 54/575 (9%)
Query: 23 LKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPA 82
+++ L EK+ D L AG +P HRL+LSA S YF F +++ EAK++EV ++ VDP
Sbjct: 172 MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPN 231
Query: 83 ILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLG 142
L+ +++Y Y+ + L + ++ + A A Q+ V VC ++L K+L P NCL I G
Sbjct: 232 ALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
Query: 143 LLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMK 202
C L A ++ + F+++ K ++F+ L E+ ++ +D +NV EE +F A+M+
Sbjct: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
Query: 203 WVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQK------KIKVLK 256
WV D +NR L + IR L+ + D +E + + + QK K +L
Sbjct: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLMEAMKYHLLP 410
Query: 257 DAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVA 316
+ + P K+ G + VG D + G T
Sbjct: 411 ER-RSMMQSPRTKPRKSTVGALYA-VGGMDAMKG--------------------TTTIEK 448
Query: 317 YDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIAS 376
YD N +L R + N++YVVGG D ++ + + +
Sbjct: 449 YDLRTNS-WLHIGTMNGRRLQFGVAVIDNKLYVVGGR--DGLKTLNTVECF----NPVGK 501
Query: 377 EWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIK 436
W +PP+ + R G+ ++ +Y V G D + L++V +DP +WN V +
Sbjct: 502 IWTVMPPMSTHRHGLGVATLEGPMYAVGGHD--GWSYLNTVERWDPEGRQWNYVASMSTP 559
Query: 437 VYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGK 496
V++ +Y +GG+ D C + F+P W APM R GVA + G
Sbjct: 560 RSTVGVVALNNKLYAIGGR-DGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGF 618
Query: 497 IVIAGGVTEDG------LSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGF 550
+ + GG LS VE +D + W + R ++++ L LY +GG+
Sbjct: 619 LYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY 678
Query: 551 AMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEI 585
T +N + Y+ + EW ++E+
Sbjct: 679 D---------GHTYLNTVESYDAQRNEWKESMQEL 704
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 208 bits (529), Expect = 1e-53
Identities = 148/568 (26%), Positives = 251/568 (44%), Gaps = 54/568 (9%)
Query: 23 LKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPA 82
+++ L EK+ D L AG +P HRL+LSA S YF F +++ EAK++EV ++ VDP
Sbjct: 172 MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPN 231
Query: 83 ILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLG 142
L+ +++Y Y+ + L + ++ + A A Q+ V VC ++L K+L P NCL I G
Sbjct: 232 ALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
Query: 143 LLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMK 202
C L A ++ + F+++ K ++F+ L E+ ++ +D +NV EE +F A+M+
Sbjct: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
Query: 203 WVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQK------KIKVLK 256
WV D +NR L + IR L+ + D +E + + + QK K +L
Sbjct: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLMEAMKYHLLP 410
Query: 257 DAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVA 316
+ + P K+ G + VG D + G T
Sbjct: 411 ER-RSMMQSPRTKPRKSTVGALYA-VGGMDAMKG--------------------TTTIEK 448
Query: 317 YDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIAS 376
YD N +L R + N++YVVGG D ++ + + +
Sbjct: 449 YDLRTNS-WLHIGTMNGRRLQFGVAVIDNKLYVVGGR--DGLKTLNTVECF----NPVGK 501
Query: 377 EWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIK 436
W +PP+ + R G+ ++ +Y V G D + L++V +DP +WN V +
Sbjct: 502 IWTVMPPMSTHRHGLGVATLEGPMYAVGGHD--GWSYLNTVERWDPEGRQWNYVASMSTP 559
Query: 437 VYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGK 496
V++ +Y +GG+ D C + F+P W APM R GVA + G
Sbjct: 560 RSTVGVVALNNKLYAIGGR-DGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGF 618
Query: 497 IVIAGGVTEDG------LSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGF 550
+ + GG LS VE +D + W + R ++++ L LY +GG+
Sbjct: 619 LYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY 678
Query: 551 AMIQLESKEFAPTEVNDIWKYEDDKKEW 578
T +N + Y+ + EW
Sbjct: 679 D---------GHTYLNTVESYDAQRNEW 697
Score = 48.5 bits (114), Expect = 2e-05
Identities = 42/165 (25%), Positives = 68/165 (41%), Gaps = 11/165 (6%)
Query: 334 PRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGL 393
PR+ +V N++Y +GG + L+S + D ++W P+ R G+
Sbjct: 559 PRSTVGVVALNNKLYAIGG-----RDGSSCLKSMEY-FDPHTNKWSLCAPMSKRRGGVGV 612
Query: 394 GEVDDKIYVVAGKDLQTEASL----DSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMI 449
+ +YVV G D D V YDP W+ V L + V +
Sbjct: 613 ATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKL 672
Query: 450 YCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHK 494
Y +GG D N V ++ ++ +WK+ P+ I R+ V V K
Sbjct: 673 YVVGG-YDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVK 716
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 202 bits (514), Expect = 7e-52
Identities = 145/534 (27%), Positives = 247/534 (46%), Gaps = 36/534 (6%)
Query: 23 LKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPA 82
+ +L ++ D + A D + HR++L+ACSPYF F ++ E+K K++ + +VD
Sbjct: 40 MNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQ 99
Query: 83 ILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLG 142
L +I Y+Y+A I++ + NVQ + AS Q+ V C +LQ +L P NCL I
Sbjct: 100 TLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFA 159
Query: 143 LLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMK 202
+ C L A + F ++ E+F+ LS ++ S+IS+D L V EE VFEAV+
Sbjct: 160 DVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVIS 219
Query: 203 WVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQK-KIKVLKDAFAG 261
W+ +KE R+++++++ + +R L+ Y VE++ +IK+N + I+ +K
Sbjct: 220 WINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHL-- 277
Query: 262 KLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPTE 321
LP D+ LL PR + + ++++V A A E
Sbjct: 278 -LPL------------------DQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVE 318
Query: 322 NECYLTALAEQIP-----RNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIAS 376
+ +QI R + +V +Y VGG + + + + Y D +
Sbjct: 319 CYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGF--NGSLRVRTVDVY----DGVKD 372
Query: 377 EWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIK 436
+W + + R G ++D +Y V G D T L SV Y +W V + +
Sbjct: 373 QWTSIASMQERRSTLGAAVLNDLLYAVGGFDGST--GLASVEAYSYKTNEWFFVAPMNTR 430
Query: 437 VYGHNVISHKGMIYCLGGKTD-DKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKG 495
V +G +Y +GG ++C + V +NP +W +A M RS GV V G
Sbjct: 431 RSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSG 490
Query: 496 KIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGG 549
++ GG + SVE +D TN W + + R + + ++ G LY +GG
Sbjct: 491 QLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGG 544
Score = 77.4 bits (189), Expect = 4e-14
Identities = 46/152 (30%), Positives = 74/152 (48%), Gaps = 3/152 (1%)
Query: 399 KIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDD 458
K+ +V G Q ++ SV CYD +W+++ +LP + V+ G +Y +GG
Sbjct: 301 KVMIVVGG--QAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGS 358
Query: 459 KKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLT 518
+ V +++ K W +A M+ RS G AV + GG ASVEA+
Sbjct: 359 LR-VRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYK 417
Query: 519 TNKWDVMTEFPQERSSISLVSLAGSLYAIGGF 550
TN+W + RSS+ + + G LYA+GG+
Sbjct: 418 TNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGY 449
Score = 50.4 bits (119), Expect = 5e-06
Identities = 36/133 (27%), Positives = 59/133 (44%), Gaps = 25/133 (18%)
Query: 464 RVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWD 523
R+ I NP+ K P+ +P+ M ++ GG + SVE +D ++WD
Sbjct: 283 RLLIKNPRT---KPRTPVSLPKVM----------IVVGGQAPKAIR-SVECYDFEEDRWD 328
Query: 524 VMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGM-- 581
+ E P R +V +AG +YA+GGF V + Y+ K +W +
Sbjct: 329 QIAELPSRRCRAGVVFMAGHVYAVGGFN---------GSLRVRTVDVYDGVKDQWTSIAS 379
Query: 582 LKEIRYASGASCL 594
++E R GA+ L
Sbjct: 380 MQERRSTLGAAVL 392
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 199 bits (507), Expect = 5e-51
Identities = 146/530 (27%), Positives = 238/530 (44%), Gaps = 47/530 (8%)
Query: 28 DEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPAILDLI 87
D + F D + K PCHR +LSACS YFR F ++ E+++ V ++ + ++
Sbjct: 61 DSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECF 120
Query: 88 IKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDC 147
++Y+Y+ + + NVQ +F +S FQI + C +L+++L P NCL I R
Sbjct: 121 LQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSL 180
Query: 148 PRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVRTD 207
L + F F + + E+F++L ELI I +D L + KEE VFEAVM+WV
Sbjct: 181 KTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRA 240
Query: 208 KENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDL------QKKIKVLKDAFAG 261
+ R L E+ +R L+ YF VE D +I+++P+ ++ +L +
Sbjct: 241 VDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMS 300
Query: 262 KLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPTE 321
P ++ TG EV VG + + G+ N YDP
Sbjct: 301 PRTRPRRS---TGYSEVIVVVGGCERVGGF------------------NLPYTECYDPVT 339
Query: 322 NECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGL 381
E A + ++ ++ +N I V GG + + Y QL+ W+ +
Sbjct: 340 GEWKSLAKLPEFTKSEYAVCALRNDILVSGG-----RINSRDVWIYNSQLNI----WIRV 390
Query: 382 PPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHN 441
L R + + K+YVV G D Q L SV CYD + +W EV L V
Sbjct: 391 ASLNKGRWRHKMAVLLGKVYVVGGYDGQNR--LSSVECYDSFSNRWTEVAPLKEAVSSPA 448
Query: 442 VISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAG 501
V S G ++ +GG DD C+++V ++P+ W A + I + I +AG
Sbjct: 449 VTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAG 508
Query: 502 GVTEDGLSASVEAFDLTTNKW-DVMTEFP-QERSSISLVSLAGSLYAIGG 549
G+T+ ++ +D + W V F QE +S+ + G +Y +GG
Sbjct: 509 GLTK-----AIYCYDPVEDYWMHVQNTFSRQENCGMSVCN--GKIYILGG 551
Score = 48.9 bits (115), Expect = 1e-05
Identities = 38/150 (25%), Positives = 67/150 (44%), Gaps = 13/150 (8%)
Query: 346 QIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAG 405
+++V+GG D D+ +QSY D + W+ +P A+ +++ IYV G
Sbjct: 455 KLFVIGGGPDDNTCSDK-VQSY----DPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG 509
Query: 406 KDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRV 465
++ CYDPV W V+ + + G IY LGG+ ++ + T+ +
Sbjct: 510 LT-------KAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTI 562
Query: 466 FIFNPKKGDWKDLAPMKIPRSMFG-VAVHK 494
++P +A M P S G V +H+
Sbjct: 563 LCYDPATSIITGVAAMPRPVSYHGCVTIHR 592
Score = 36.6 bits (83), Expect = 0.069
Identities = 21/84 (25%), Positives = 40/84 (47%), Gaps = 4/84 (4%)
Query: 468 FNPKKGDWKDLAPM-KIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMT 526
++P G+WK LA + + +S + V + I+++GG S V ++ N W +
Sbjct: 335 YDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRIN---SRDVWIYNSQLNIWIRVA 391
Query: 527 EFPQERSSISLVSLAGSLYAIGGF 550
+ R + L G +Y +GG+
Sbjct: 392 SLNKGRWRHKMAVLLGKVYVVGGY 415
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 199 bits (507), Expect = 5e-51
Identities = 150/589 (25%), Positives = 260/589 (44%), Gaps = 51/589 (8%)
Query: 7 LAEELRLYQSTLLQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEI 66
LA L+ LLQ GL L + D L+ GD + H+++L++ SPYF+ F +
Sbjct: 10 LANLTHLHSEQLLQ-GLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNL 68
Query: 67 DEAKKKEVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYL 126
E + EV +D L I++Y Y+ ++ ++ V+ + A+ QI V C ++L
Sbjct: 69 SEKENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFL 128
Query: 127 QKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISND 186
+ +L PGNC+ I R C L ++A +++ F +C+ E+F +L+ +L ++SND
Sbjct: 129 ESQLDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSND 188
Query: 187 SLNVEKEEAVFEAVMKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNP 246
LNV EE VF A+ W++ D + R K L+++ + +R L++ K+ E + +I+ +
Sbjct: 189 CLNVATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDR 248
Query: 247 DLQKKI-KVLKDAFAGKLPEPSKNAAKTG---AGEVNGDVGDEDLLPGYLNDIPRHGMFV 302
+ + + LK F + + T A +V VG + L L+ +
Sbjct: 249 TCKHLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDSVE------ 302
Query: 303 KDLILLVNDTAAVAYDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLY------VD 356
Y P +N+ ++ IPR I ++YV+GG+ V
Sbjct: 303 -------------MYFP-QNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVT 348
Query: 357 EENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDS 416
+ ++ + + + W L + +R G+ + ++Y + G D Q + L S
Sbjct: 349 IRKHENSVECW----NPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQ--SYLQS 402
Query: 417 VLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWK 476
V Y P KW V + GMIY +GG N V ++P K W+
Sbjct: 403 VEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY--GPAHMNSVERYDPSKDSWE 460
Query: 477 DLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSIS 536
+A M R FGV V G I + GG +S+E +D N+W V + R+ +
Sbjct: 461 MVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVG 520
Query: 537 LVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEW---AGML 582
+ LY +GG + + +N + KY+ W AGM+
Sbjct: 521 AAVIDNYLYVVGGHS---------GSSYLNTVQKYDPISDTWLDSAGMI 560
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 198 bits (503), Expect = 1e-50
Identities = 133/575 (23%), Positives = 260/575 (45%), Gaps = 41/575 (7%)
Query: 23 LKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPA 82
+ ++ +K D L ++ +P HR++L+A S +F F + + E+K EV L + +P
Sbjct: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93
Query: 83 ILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLG 142
I++ ++++ Y+A I +N NVQ + A+++QI V +CV +L++++ NCL I L
Sbjct: 94 IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153
Query: 143 LLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMK 202
LDCP L +A +F+ F ++ K ++F+QL + + +++ D+L V E+ V++A ++
Sbjct: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213
Query: 203 WVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGK 262
W++ D+ NR + ++ +RF L+++ + V+ + +I+ NP+ +K++
Sbjct: 214 WLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPEC---LKMVISGMRYH 270
Query: 263 LPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPTEN 322
L P E+L+ G +H + + + + Y ++
Sbjct: 271 LLSPEDR---------------EELVDGTRPRRKKHDYRI--ALFGGSQPQSCRYFNPKD 313
Query: 323 ECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLP 382
+ R ++ V N +Y++GG + + + Y DS W
Sbjct: 314 YSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFPIKR---MDCYNVVKDS----WYSKL 366
Query: 383 PLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNV 442
P+ R + KIY G ++ A L CYD W+ + + H +
Sbjct: 367 GPPTPRDSLAACAAEGKIYTSGGSEVGNSA-LYLFECYDTRTESWHTKPSMLTQRCSHGM 425
Query: 443 ISHKGMIYCLGGKTDDK---KCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVI 499
+ G+IY GG + + N +++P W +L PM R G+ K KI
Sbjct: 426 VEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFA 485
Query: 500 AGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKE 559
GG G +VE +D+ N+W +++ P + ++ ++ +Y + GF +
Sbjct: 486 VGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGV------ 539
Query: 560 FAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCL 594
+ I +Y + +W K +R SCL
Sbjct: 540 ---GRLGHILEYNTETDKWVANSK-VRAFPVTSCL 570
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 197 bits (501), Expect = 2e-50
Identities = 152/590 (25%), Positives = 259/590 (43%), Gaps = 58/590 (9%)
Query: 23 LKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPA 82
+++ L K+ D L AGD+ +P HRL+LS+ S YF F +++ EA+++E+ ++ V+P
Sbjct: 164 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPN 223
Query: 83 ILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLG 142
L +I+Y Y+ ++L + N++ + + A Q+ V C +L K+L P NCL I
Sbjct: 224 SLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFA 283
Query: 143 LLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMK 202
C L A + + F+++ + ++F+ L E+ ++++D +N+ EE + A++
Sbjct: 284 DAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLT 343
Query: 203 WVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKV-----LKD 257
WVR D E R K+LS++ IR L+ ++ D +E + + + + + QK I L
Sbjct: 344 WVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLP 402
Query: 258 AFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAY 317
L P K+ G + VG D G T+ Y
Sbjct: 403 ERRPMLQSPRTKPRKSTVGTLFA-VGGMDSTKG--------------------ATSIEKY 441
Query: 318 DPTENECYLTALAEQIPRN-HSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIAS 376
D N T +A R + +++YVVGG D ++ Y +
Sbjct: 442 DLRTN--MWTPVANMNGRRLQFGVAVLDDKLYVVGGR--DGLKTLNTVECY----NPKTK 493
Query: 377 EWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKL--P 434
W +PP+ + R G+ ++ +Y V G D + L++V +DP A +WN V + P
Sbjct: 494 TWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD--GWSYLNTVERWDPQARQWNFVATMSTP 551
Query: 435 IKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHK 494
G V+S G +Y +GG+ D C V F+P W A M R GV
Sbjct: 552 RSTVGVAVLS--GKLYAVGGR-DGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWN 608
Query: 495 GKIVIAGGVTEDG------LSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIG 548
G + GG LS VE +D T+ W + R ++ + L LYA+G
Sbjct: 609 GLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 668
Query: 549 GFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRL 598
G+ +N + Y+ EW + +GA + +L
Sbjct: 669 GYD---------GQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 709
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 197 bits (501), Expect = 2e-50
Identities = 152/590 (25%), Positives = 259/590 (43%), Gaps = 58/590 (9%)
Query: 23 LKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPA 82
+++ L K+ D L AGD+ +P HRL+LS+ S YF F +++ EA+++E+ ++ V+P
Sbjct: 210 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPN 269
Query: 83 ILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLG 142
L +I+Y Y+ ++L + N++ + + A Q+ V C +L K+L P NCL I
Sbjct: 270 SLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFA 329
Query: 143 LLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMK 202
C L A + + F+++ + ++F+ L E+ ++++D +N+ EE + A++
Sbjct: 330 DAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLT 389
Query: 203 WVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKV-----LKD 257
WVR D E R K+LS++ IR L+ ++ D +E + + + + + QK I L
Sbjct: 390 WVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLP 448
Query: 258 AFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAY 317
L P K+ G + VG D G T+ Y
Sbjct: 449 ERRPMLQSPRTKPRKSTVGTLFA-VGGMDSTKG--------------------ATSIEKY 487
Query: 318 DPTENECYLTALAEQIPRN-HSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIAS 376
D N T +A R + +++YVVGG D ++ Y +
Sbjct: 488 DLRTN--MWTPVANMNGRRLQFGVAVLDDKLYVVGGR--DGLKTLNTVECY----NPKTK 539
Query: 377 EWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKL--P 434
W +PP+ + R G+ ++ +Y V G D + L++V +DP A +WN V + P
Sbjct: 540 TWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD--GWSYLNTVERWDPQARQWNFVATMSTP 597
Query: 435 IKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHK 494
G V+S G +Y +GG+ D C V F+P W A M R GV
Sbjct: 598 RSTVGVAVLS--GKLYAVGGR-DGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWN 654
Query: 495 GKIVIAGGVTEDG------LSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIG 548
G + GG LS VE +D T+ W + R ++ + L LYA+G
Sbjct: 655 GLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 714
Query: 549 GFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRL 598
G+ +N + Y+ EW + +GA + +L
Sbjct: 715 GYD---------GQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 755
>gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Homo
sapiens]
Length = 623
Score = 197 bits (500), Expect = 3e-50
Identities = 148/553 (26%), Positives = 236/553 (42%), Gaps = 76/553 (13%)
Query: 14 YQSTLLQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKE 73
Y +LL+ LK +++ F D L PCH+++L+ CS YFR F+S + E+K+
Sbjct: 13 YAVSLLEQ-LKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTH 71
Query: 74 VVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPG 133
V L NVD A L +II Y Y+ ++ +ND V+ ++ A Q+ V C YL K++
Sbjct: 72 VHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAE 131
Query: 134 NCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKE 193
NC+ +L L C L SA+ V +F + ++ FMQLS LI ++S+D+LNVEKE
Sbjct: 132 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKE 191
Query: 194 EAVFEAVMKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIK 253
E V EA M W+ + E+R + LS V IR ++E
Sbjct: 192 ETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSE------------------------ 227
Query: 254 VLKDAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDT- 312
V + A+ LP K+ G + +P + PR GM +++++ + +
Sbjct: 228 VTQRAWFQGLPPNDKSVVVQGLYK---------SMPKFFK--PRLGMTKEEMMIFIEASS 276
Query: 313 -------AAVAYDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLY-----VDEENK 360
++V Y P + Y ++VT N IY+ GG +K
Sbjct: 277 ENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSK 336
Query: 361 DQPLQ------SYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASL 414
LQ + F+ D+ + W P+ R L + IY + G + E +
Sbjct: 337 TSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNR 396
Query: 415 DSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGD 474
+V YD +W V LP + IY + N ++ + P+
Sbjct: 397 RTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVM--------TLNLMYCYFPRSDS 448
Query: 475 WKDLAPMKIPRSMFGVAVHKGKIVIAGGV-------------TEDGLSASVEAFDLTTNK 521
W ++A + RS A KI GG+ T DG S +VE +D+ N+
Sbjct: 449 WVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTVEIYDVNKNE 508
Query: 522 WDVMTEFPQERSS 534
W + P +R S
Sbjct: 509 WKMAANIPAKRYS 521
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 197 bits (500), Expect = 3e-50
Identities = 133/569 (23%), Positives = 257/569 (45%), Gaps = 41/569 (7%)
Query: 29 EKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPAILDLII 88
+K D L ++ +P HR++L+A S +F F + + E+K EV L + +P I++ ++
Sbjct: 18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLV 77
Query: 89 KYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCP 148
++ Y+A I +N NVQ + A+++QI V +CV +L++++ NCL I L LDCP
Sbjct: 78 EFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCP 137
Query: 149 RLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVRTDK 208
L +A +F+ F ++ K ++F+QL + + +++ D+L V E+ V++A ++W++ D+
Sbjct: 138 ELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 197
Query: 209 ENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGKLPEPSK 268
NR + ++ +RF L+++ + V+ + +I+ NP+ +K++ L P
Sbjct: 198 PNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPEC---LKMVISGMRYHLLSPED 254
Query: 269 NAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPTENECYLTA 328
E+L+ G +H + + + + Y ++ +
Sbjct: 255 R---------------EELVDGTRPRRKKHDYRI--ALFGGSQPQSCRYFNPKDYSWTDI 297
Query: 329 LAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSAR 388
R ++ V N +Y++GG + + + Y DS W P+ R
Sbjct: 298 RCPFEKRRDAACVFWDNVVYILGGSQLFPIKR---MDCYNVVKDS----WYSKLGPPTPR 350
Query: 389 CLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGM 448
+ KIY G ++ A L CYD W+ + + H ++ G+
Sbjct: 351 DSLAACAAEGKIYTSGGSEVGNSA-LYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGL 409
Query: 449 IYCLGGKTDDK---KCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTE 505
IY GG + + N +++P W +L PM R G+ K KI GG
Sbjct: 410 IYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNG 469
Query: 506 DGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEV 565
G +VE +D+ N+W +++ P + ++ ++ +Y + GF + +
Sbjct: 470 LGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGV---------GRL 520
Query: 566 NDIWKYEDDKKEWAGMLKEIRYASGASCL 594
I +Y + +W K +R SCL
Sbjct: 521 GHILEYNTETDKWVANSK-VRAFPVTSCL 548
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 194 bits (494), Expect = 2e-49
Identities = 140/568 (24%), Positives = 242/568 (42%), Gaps = 36/568 (6%)
Query: 29 EKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPAILDLII 88
E K D +K H+ IL +CS YFR F S + +KK + + P ++ LII
Sbjct: 35 EGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLII 94
Query: 89 KYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCP 148
+Y Y+ ++ + NV+ + A A +F I + C +L+ L NC+ I + CP
Sbjct: 95 EYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCP 154
Query: 149 RLAISAREFVSDRFVQICK-EEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVRTD 207
L A F+ F ++ K +F++LS EL +I D LNV++E+AVFEA++KW+ D
Sbjct: 155 ELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHD 214
Query: 208 KENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKK-IKVLKDAFAGKLPEP 266
+NR +++S + +R LM +YF ++V+ +D +K + + + I LK + + P
Sbjct: 215 PQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGP 274
Query: 267 SKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPTENECYL 326
S + + G+ P + A AYD +
Sbjct: 275 SNSDFTNPLTRPRLPYAILFAIGGWSGGSPTN--------------AIEAYDARADRWVN 320
Query: 327 TALAEQIPRNHSSIVTQQNQIYVVGGL-YVDEENKDQPLQSYFFQLDSIASEWVGLPPLP 385
E+ PR + + +Y++GG VD N + + D + W + P+
Sbjct: 321 VTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVK-------RFDPVKKTWHQVAPMH 373
Query: 386 SARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISH 445
S RC + + + IY + G D L++ Y+P +W + + + + +
Sbjct: 374 SRRCYVSVTVLGNFIYAMGGFD--GYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTL 431
Query: 446 KGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTE 505
G +Y GG + +C ++N + W +APM+ RS GV + + GG
Sbjct: 432 YGKVYICGG-FNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDG 490
Query: 506 DGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEV 565
S EA+ N W + RS+ + + L+ +GGF T
Sbjct: 491 ANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGF---------TTT 541
Query: 566 NDIWKYEDDKKEWAGMLKEIRYASGASC 593
++ Y++ EW Y S SC
Sbjct: 542 FNVECYDEKTDEWYDAHDMSIYRSALSC 569
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 194 bits (493), Expect = 2e-49
Identities = 144/565 (25%), Positives = 252/565 (44%), Gaps = 42/565 (7%)
Query: 23 LKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPA 82
++ L +++ D L G++ +P HRL+LS+ S YF F S++ EAK++E+ ++ +DP
Sbjct: 202 MESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPN 261
Query: 83 ILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLG 142
L ++++ Y+ ++L + ++++ A A Q+P V VC +L K L P NCL I
Sbjct: 262 ALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFA 321
Query: 143 LLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMK 202
C L A + + +++ + ++F+ L +EL ++++D +NV EE +F A+M
Sbjct: 322 DAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMM 381
Query: 203 WVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGK 262
WV+ D ++R +LS + IR L+ + D +E + K++ + QK I L+
Sbjct: 382 WVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQKLI--LEAMKYHL 438
Query: 263 LPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPTEN 322
LPE VG + G N+ T YD N
Sbjct: 439 LPERRTLMQSPRTKPRKSTVGTLYAVGGMDNN--------------KGATTIEKYDLRTN 484
Query: 323 ECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLP 382
++ A R + ++++V+GG D ++ Y + W LP
Sbjct: 485 -LWIQAGMMNGRRLQFGVAVIDDKLFVIGGR--DGLKTLNTVECY----NPKTKTWTVLP 537
Query: 383 PLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNV 442
P+ + R G+ ++ IY V G D + L++V +DP + +W V + I V
Sbjct: 538 PMSTHRHGLGVTVLEGPIYAVGGHD--GWSYLNTVERWDPQSQQWTFVASMSIARSTVGV 595
Query: 443 ISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGG 502
+ G +Y +GG+ D C + + ++P W APM R GVA G + GG
Sbjct: 596 AALNGKLYSVGGR-DGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGG 654
Query: 503 VTEDG------LSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLE 556
L VE +D T+ W ++ R ++ + L LYA+GG+
Sbjct: 655 HDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYD----- 709
Query: 557 SKEFAPTEVNDIWKYEDDKKEWAGM 581
T +N + Y+ EW M
Sbjct: 710 ----GQTYLNTMESYDPQTNEWTQM 730
Score = 43.1 bits (100), Expect = 7e-04
Identities = 44/182 (24%), Positives = 71/182 (39%), Gaps = 12/182 (6%)
Query: 317 YDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIAS 376
+DP + A + I R+ + ++Y VGG D + ++ Y D +
Sbjct: 573 WDPQSQQWTFVA-SMSIARSTVGVAALNGKLYSVGGR--DGSSCLSSMEYY----DPHTN 625
Query: 377 EWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEAS----LDSVLCYDPVAAKWNEVKK 432
+W P+ R G+ D +Y V G D LD V YDP W V
Sbjct: 626 KWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAP 685
Query: 433 LPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAV 492
L + V +Y +GG D + N + ++P+ +W +A + I R+ V V
Sbjct: 686 LSMPRDAVGVCLLGDRLYAVGGY-DGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVV 744
Query: 493 HK 494
K
Sbjct: 745 IK 746
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 193 bits (490), Expect = 4e-49
Identities = 140/536 (26%), Positives = 242/536 (45%), Gaps = 40/536 (7%)
Query: 23 LKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPA 82
+ +L + D T+ A D + HR++L+ACSPYF F E+ E++ K V + VD
Sbjct: 50 MNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGW 109
Query: 83 ILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLG 142
L ++I Y+Y+A I + + NVQ + A Q+ V C +L+ +L P NCL I
Sbjct: 110 TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFA 169
Query: 143 LLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMK 202
+ C L A + F + E+F+ L +++ S+IS+D L + EE VFEAV+
Sbjct: 170 DMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIA 229
Query: 203 WVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGK 262
WV DK+ R + ++ + + +R L+ +Y VE++ ++K++ K +++
Sbjct: 230 WVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSAC--KDYLIEAMKYHL 287
Query: 263 LPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVA------ 316
LP + K+ + R M + L+++V A A
Sbjct: 288 LPTEQRILMKSVRTRL------------------RTPMNLPKLMVVVGGQAPKAIRSVEC 329
Query: 317 YDPTENECYLTALAEQIP--RNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSI 374
YD E + A ++P R + +V ++ VGG + + + + SY D +
Sbjct: 330 YDFKEERWHQVA---ELPSRRCRAGMVYMAGLVFAVGGF--NGSLRVRTVDSY----DPV 380
Query: 375 ASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLP 434
+W + + R G ++ +Y V G D T L SV Y+ + +W V +
Sbjct: 381 KDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGST--GLSSVEAYNIKSNEWFHVAPMN 438
Query: 435 IKVYGHNVISHKGMIYCLGGKTD-DKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVH 493
+ V G++Y +GG ++C + V +N +W +A M RS GV V
Sbjct: 439 TRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVL 498
Query: 494 KGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGG 549
+ GG + SVE +D TTN W + + R + + ++ G LY +GG
Sbjct: 499 NNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG 554
Score = 78.6 bits (192), Expect = 2e-14
Identities = 46/152 (30%), Positives = 78/152 (51%), Gaps = 3/152 (1%)
Query: 399 KIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDD 458
K+ VV G Q ++ SV CYD +W++V +LP + ++ G+++ +GG
Sbjct: 311 KLMVVVGG--QAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGS 368
Query: 459 KKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLT 518
+ V ++P K W +A M+ RS G AV G + GG +SVEA+++
Sbjct: 369 LR-VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIK 427
Query: 519 TNKWDVMTEFPQERSSISLVSLAGSLYAIGGF 550
+N+W + RSS+ + + G LYA+GG+
Sbjct: 428 SNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGY 459
Score = 44.3 bits (103), Expect = 3e-04
Identities = 30/117 (25%), Positives = 50/117 (42%), Gaps = 22/117 (18%)
Query: 480 PMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVS 539
PM +P+ M V+ GG + SVE +D +W + E P R +V
Sbjct: 306 PMNLPKLM----------VVVGGQAPKAIR-SVECYDFKEERWHQVAELPSRRCRAGMVY 354
Query: 540 LAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGM--LKEIRYASGASCL 594
+AG ++A+GGF V + Y+ K +W + +++ R GA+ L
Sbjct: 355 MAGLVFAVGGFN---------GSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVL 402
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 193 bits (490), Expect = 4e-49
Identities = 140/536 (26%), Positives = 242/536 (45%), Gaps = 40/536 (7%)
Query: 23 LKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPA 82
+ +L + D T+ A D + HR++L+ACSPYF F E+ E++ K V + VD
Sbjct: 46 MNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGW 105
Query: 83 ILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLG 142
L ++I Y+Y+A I + + NVQ + A Q+ V C +L+ +L P NCL I
Sbjct: 106 TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFA 165
Query: 143 LLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMK 202
+ C L A + F + E+F+ L +++ S+IS+D L + EE VFEAV+
Sbjct: 166 DMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIA 225
Query: 203 WVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGK 262
WV DK+ R + ++ + + +R L+ +Y VE++ ++K++ K +++
Sbjct: 226 WVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSAC--KDYLIEAMKYHL 283
Query: 263 LPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVA------ 316
LP + K+ + R M + L+++V A A
Sbjct: 284 LPTEQRILMKSVRTRL------------------RTPMNLPKLMVVVGGQAPKAIRSVEC 325
Query: 317 YDPTENECYLTALAEQIP--RNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSI 374
YD E + A ++P R + +V ++ VGG + + + + SY D +
Sbjct: 326 YDFKEERWHQVA---ELPSRRCRAGMVYMAGLVFAVGGF--NGSLRVRTVDSY----DPV 376
Query: 375 ASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLP 434
+W + + R G ++ +Y V G D T L SV Y+ + +W V +
Sbjct: 377 KDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGST--GLSSVEAYNIKSNEWFHVAPMN 434
Query: 435 IKVYGHNVISHKGMIYCLGGKTD-DKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVH 493
+ V G++Y +GG ++C + V +N +W +A M RS GV V
Sbjct: 435 TRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVL 494
Query: 494 KGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGG 549
+ GG + SVE +D TTN W + + R + + ++ G LY +GG
Sbjct: 495 NNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG 550
Score = 78.6 bits (192), Expect = 2e-14
Identities = 46/152 (30%), Positives = 78/152 (51%), Gaps = 3/152 (1%)
Query: 399 KIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDD 458
K+ VV G Q ++ SV CYD +W++V +LP + ++ G+++ +GG
Sbjct: 307 KLMVVVGG--QAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGS 364
Query: 459 KKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLT 518
+ V ++P K W +A M+ RS G AV G + GG +SVEA+++
Sbjct: 365 LR-VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIK 423
Query: 519 TNKWDVMTEFPQERSSISLVSLAGSLYAIGGF 550
+N+W + RSS+ + + G LYA+GG+
Sbjct: 424 SNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGY 455
Score = 44.3 bits (103), Expect = 3e-04
Identities = 30/117 (25%), Positives = 50/117 (42%), Gaps = 22/117 (18%)
Query: 480 PMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVS 539
PM +P+ M V+ GG + SVE +D +W + E P R +V
Sbjct: 302 PMNLPKLM----------VVVGGQAPKAIR-SVECYDFKEERWHQVAELPSRRCRAGMVY 350
Query: 540 LAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGM--LKEIRYASGASCL 594
+AG ++A+GGF V + Y+ K +W + +++ R GA+ L
Sbjct: 351 MAGLVFAVGGFN---------GSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVL 398
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 189 bits (479), Expect = 8e-48
Identities = 145/538 (26%), Positives = 239/538 (44%), Gaps = 31/538 (5%)
Query: 16 STLLQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVV 75
S +LQ+GL+ L E D L + CHR++L+A S YFR F +++ E +K ++
Sbjct: 55 SLILQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRII 114
Query: 76 LDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNC 135
+ VD + ++ Y Y++ + NVQ + A+ FQ + C S+L + L P NC
Sbjct: 115 IKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENC 174
Query: 136 LAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEA 195
+ ILRL L + ++ FVQI E+F+ L L ++ +D L V +E
Sbjct: 175 VGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQ 234
Query: 196 VFEAVMKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVL 255
VFE VM WVR R+ L V + +R L+ YF + VE D +I+ P++ +L
Sbjct: 235 VFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEV---FPLL 291
Query: 256 KDAFAGKLP--EPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTA 313
++A L E K E +V ++ G R V L L
Sbjct: 292 QEARMYHLSGNEIISERTKPRMHEFQSEV---FMIIGGCTKDERFVAEVTCLDPLRRSRL 348
Query: 314 AVAYDP-TENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLD 372
VA P TE+E +E + VT +N++Y+ GG + Q ++ +
Sbjct: 349 EVAKLPLTEHELE----SENKKWVEFACVTLKNEVYISGG---------KETQHDVWKYN 395
Query: 373 SIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKD-LQTEASLDSVLCYDPVAAKWNEVK 431
S ++W+ + L R + + K+YV+ G D LQ +++V YDP W+E
Sbjct: 396 SSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQ---RINNVETYDPFHNCWSEAA 452
Query: 432 KLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVA 491
L + V SHK +Y +GG + K T++ ++P W A M +
Sbjct: 453 PLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAV 512
Query: 492 VHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGG 549
+ +I + GG ++ A+ + W ++T+ ER+S + LY GG
Sbjct: 513 SFRDRIYVVGGAMR-----ALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGG 565
Score = 47.8 bits (112), Expect = 3e-05
Identities = 36/128 (28%), Positives = 61/128 (47%), Gaps = 13/128 (10%)
Query: 317 YDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIAS 376
YDP+ N+ L A A + + V+ +++IYVVGG + L +Y +
Sbjct: 489 YDPSTNKWSLKA-AMPVEAKCINAVSFRDRIYVVGGAM-------RALYAY----SPLED 536
Query: 377 EWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIK 436
W + L R G+ ++++Y+ G+D + E + +VLC+DP A K E LP
Sbjct: 537 SWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEV-IATVLCWDPEAQKLTEECVLPRG 595
Query: 437 VYGHNVIS 444
V H ++
Sbjct: 596 VSHHGSVT 603
Score = 35.0 bits (79), Expect = 0.20
Identities = 34/156 (21%), Positives = 67/156 (42%), Gaps = 15/156 (9%)
Query: 317 YDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIAS 376
YDP N C+ A + + + + + ++YV+GG + D+ Q Y D +
Sbjct: 441 YDPFHN-CWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKT-QCY----DPSTN 494
Query: 377 EWVGLPPLP-SARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPI 435
+W +P A+C+ + D+IYVV G ++ ++ Y P+ W V +L
Sbjct: 495 KWSLKAAMPVEAKCINAVS-FRDRIYVVGG-------AMRALYAYSPLEDSWCLVTQLSH 546
Query: 436 KVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPK 471
+ + +Y GG+ + + V ++P+
Sbjct: 547 ERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPE 582
Score = 32.3 bits (72), Expect = 1.3
Identities = 40/207 (19%), Positives = 78/207 (37%), Gaps = 50/207 (24%)
Query: 395 EVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGG 454
E +++++ G + E + V C DP+ EV KLP+ H +
Sbjct: 315 EFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTE--HEL------------ 360
Query: 455 KTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEA 514
++++KK W + A + + K ++ I+GG V
Sbjct: 361 ESENKK--------------WVEFACVTL----------KNEVYISGGKETQH---DVWK 393
Query: 515 FDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDD 574
++ + NKW + R +V L G +Y IGGF +Q +N++ Y+
Sbjct: 394 YNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQ---------RINNVETYDPF 444
Query: 575 KKEWAGMLKEIRYASGASCLATRLNLF 601
W+ + + S + + + L+
Sbjct: 445 HNCWSEAAPLLVHVSSFAATSHKKKLY 471
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 186 bits (471), Expect = 7e-47
Identities = 142/527 (26%), Positives = 242/527 (45%), Gaps = 45/527 (8%)
Query: 34 DCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPAILDLIIKYLYS 93
D TLK G K + CH+L+L+ PYFR FLSE+ EAK+ + + + D ++ ++K++YS
Sbjct: 68 DVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYS 127
Query: 94 ASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAIS 153
+ + L NVQ + A Q+ V C Y++ P NCLA+ + L
Sbjct: 128 SRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDM 187
Query: 154 AREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVRTDKENRVK 213
A ++ D F ++ + EDF+ +SPQ L ++S+ LN+E E+ V+ A +KW+ + ++ K
Sbjct: 188 ADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSK 247
Query: 214 NLSEVFDCIRFRLMT----------EKYFKDHVEKDDIIKS--NPDLQKKIKVLKDAFAG 261
L E +R L+ E+ K +++ D++ N L + + D
Sbjct: 248 WLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAVPDFEYS 307
Query: 262 KLPEPSKNAA--------KTGAGEVNGDVGDEDLLPGY------LNDIPRHG--MFVKDL 305
P K+ A + G+G+ + + +N RH + V+
Sbjct: 308 IRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGK 367
Query: 306 ILLVNDT-------AAVAYDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEE 358
+ V + +DP N+ + A + R ++ + IY +GGL D+
Sbjct: 368 VYAVGGHDGNEHLGSMEMFDPLTNKWMMKA-SMNTKRRGIALASLGGPIYAIGGL--DDN 424
Query: 359 NKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVL 418
++ Y + D +W + P+ + R G + + +Y V G D ASL SV
Sbjct: 425 TCFNDVERYDIESD----QWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGM--ASLSSVE 478
Query: 419 CYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDL 478
YDP KW EVK++ + G+ V G +Y +GG DD + V ++P+ W +
Sbjct: 479 RYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGG-FDDNSPLSSVERYDPRSNKWDYV 537
Query: 479 APMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDVM 525
A + PR G+A GKI GG + +VEAFD N+W+++
Sbjct: 538 AALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELV 584
Score = 62.8 bits (151), Expect = 9e-10
Identities = 39/133 (29%), Positives = 62/133 (46%), Gaps = 9/133 (6%)
Query: 447 GMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTED 506
G+++C+GG+ + ++ K W M R GV +GK+ GG +
Sbjct: 318 GVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGN 377
Query: 507 GLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVN 566
S+E FD TNKW + +R I+L SL G +YAIGG L+ T N
Sbjct: 378 EHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGG-----LDDN----TCFN 428
Query: 567 DIWKYEDDKKEWA 579
D+ +Y+ + +W+
Sbjct: 429 DVERYDIESDQWS 441
>gi|148664248 kelch domain containing 6 [Homo sapiens]
Length = 623
Score = 185 bits (470), Expect = 9e-47
Identities = 134/628 (21%), Positives = 283/628 (45%), Gaps = 75/628 (11%)
Query: 14 YQSTL-LQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKK 72
YQ +L L + ++++ + + ID L A + PCHRL+L+A SPYF+ F + E ++
Sbjct: 11 YQHSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQR 70
Query: 73 EVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAP 132
EV+L ++ + +++ Y+Y+A++++N+ NVQ + A Q+ VF+VC Y+ +
Sbjct: 71 EVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDA 130
Query: 133 GNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEK 192
NCL I + L+ +++++ F ++ E+ +++ + +++I +D LN+ +
Sbjct: 131 SNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISR 190
Query: 193 EEAVFEAVMKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKI 252
EE++ + V++WV +KE R +L E+ +R L+ + + + ++ ++ + D +
Sbjct: 191 EESILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADC---V 247
Query: 253 KVLKDAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDT 312
++++AF + P +++ R+GM L+L + +
Sbjct: 248 DIIQNAFKA-IKTPQQHSLNL-----------------------RYGMETTSLLLCIGNN 283
Query: 313 -------------AAVAYDPTENECYLTA---LAEQIPRNHSSIVTQQNQIYVVGGLYVD 356
A+ YDP + Y + E + + +V + N I V G
Sbjct: 284 SSGIRSRHRSYGDASFCYDPVSRKTYFISSPKYGEGLGTVCTGVVMENNTIIVAGEASAS 343
Query: 357 EENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDS 416
+ ++ + ++ +++ R L+ LG + + +YV+ G+ ++ +
Sbjct: 344 KLSRQKNKNVEIYRYHDRGNQFWEKLCTAEFRELYALGSIHNDLYVIGGQ-MKIKNQYLI 402
Query: 417 VLCYDPVAAK---WNEVKKLPIKVYGHNVISHKGMIYCLGGKT--------DDKKCTNRV 465
C D + + W V LP+++ H V++ +Y +GG T + + +N++
Sbjct: 403 TNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKL 462
Query: 466 FIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSAS--------VEAFDL 517
++P + W APMK + F AV +I + GG+ G VE ++
Sbjct: 463 LQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYNP 522
Query: 518 TTNKWDVMTEFPQ-----ERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYE 572
+ W P +S + ++ G LY GGF + E E+ ++ +E
Sbjct: 523 DGDFWREGPPMPSPLLSLRTNSTNAGAVDGKLYVCGGFH--GADRHEVISKEILELDPWE 580
Query: 573 DDKKEW-AGMLKEIRYASGASCLATRLN 599
+ +W + + + S CL R+N
Sbjct: 581 N---QWNVVAINVLMHDSYDVCLVARMN 605
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 184 bits (468), Expect = 2e-46
Identities = 139/537 (25%), Positives = 227/537 (42%), Gaps = 33/537 (6%)
Query: 26 LLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDN-VDPAIL 84
L ++ F D L AG+++ PCHR +L+ACS YF F + E++ EV DN + P +L
Sbjct: 39 LRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVL 98
Query: 85 DLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLL 144
+L++ Y YS+ + +N+ N + + + + C +L+K L P NCL +L L
Sbjct: 99 ELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDA 158
Query: 145 LDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWV 204
C +L + F I K EDF+QL ++ ++S++ L E E V+E+ + W+
Sbjct: 159 HQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWI 218
Query: 205 RTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGKLP 264
D + R L E+ +R L+ Y ++V +++I +K +++++A KL
Sbjct: 219 SYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQ---RKSKEIVEEAIRCKLK 275
Query: 265 EPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPTENEC 324
+ T G L G F+ D + LV+ A +
Sbjct: 276 ILQNDGVVTSLCARPRKTGHALFLLG-------GQTFMCDKLYLVDQKAKEIIPKADIPS 328
Query: 325 YLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPL 384
PR S ++Y+ GG + + + D++ EW P+
Sbjct: 329 ---------PRKEFSACAIGCKVYITGG-----RGSENGVSKDVWVYDTLHEEWSKAAPM 374
Query: 385 PSARCLFGLGEVDDKIYVVAGKDLQT-------EASLDSVLCYDPVAAKWNEVKKLPIKV 437
AR G E+ +YVV G T SL V YDP KW V L V
Sbjct: 375 LVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGV 434
Query: 438 YGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKI 497
V+S K ++ GG + +V ++ + W A P AV +I
Sbjct: 435 SNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQI 494
Query: 498 VIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQ 554
I GG TE + S F+ T +W + + +R S V+ LY +GG+ IQ
Sbjct: 495 FIMGGDTEFS-ACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQ 550
Score = 64.3 bits (155), Expect = 3e-10
Identities = 52/216 (24%), Positives = 91/216 (42%), Gaps = 18/216 (8%)
Query: 369 FQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWN 428
+ +D A E + +PS R F + K+Y+ G+ + S D V YD + +W+
Sbjct: 311 YLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKD-VWVYDTLHEEWS 369
Query: 429 EVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKC--------TNRVFIFNPKKGDWKDLAP 480
+ + + +GH K +Y +GG T C +V ++P W +AP
Sbjct: 370 KAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAP 429
Query: 481 MKIPRSMFGVAVHKGKIVIAGG--VTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLV 538
++ S V K K+ GG V+ D L V+ +D N+W V PQ +
Sbjct: 430 LREGVSNAAVVSAKLKLFAFGGTSVSHDKL-PKVQCYDQCENRWTVPATCPQPWRYTAAA 488
Query: 539 SLAGSLYAIGG------FAMIQLESKEFAPTEVNDI 568
L ++ +GG + + S+ + T+V D+
Sbjct: 489 VLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDV 524
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 184 bits (468), Expect = 2e-46
Identities = 145/530 (27%), Positives = 230/530 (43%), Gaps = 39/530 (7%)
Query: 32 FIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVL-DNVDPAILDLIIKY 90
F D TL AGD++ PCHR +L+A S YF F + E++ V DN+ P +L+L++ +
Sbjct: 45 FTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDF 104
Query: 91 LYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRL 150
YS+ I +N+ N + + Q V +L+K L P NCL ++ L C RL
Sbjct: 105 AYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRL 164
Query: 151 AISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVRTDKEN 210
+ F + + EDF LS L+ +IS+D L E E VFEA+++WV+ D E
Sbjct: 165 YEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEP 224
Query: 211 RVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGKLPEPSKNA 270
R +L E+ +R L+ ++ V + ++ ++ ++ K++ D
Sbjct: 225 RKVHLPELLRSVRLALLPSDCLQEAVSSEALLMAD----ERTKLIMD---------EALR 271
Query: 271 AKTGAGEVNGDVGDEDLLP---GYLNDIPRHGMFVKDLILLVNDTAAVAYDPTENECYLT 327
KT + +G V P G+ I F+ D I V+ A +
Sbjct: 272 CKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPS--- 328
Query: 328 ALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSA 387
PR S ++YV GG + + + D++ EW P+ A
Sbjct: 329 ------PRKEFSASAIGCKVYVTGG-----RGSENGVSKDVWVYDTVHEEWSKAAPMLIA 377
Query: 388 RCLFGLGEVDDKIYVVAGK-------DLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGH 440
R G E+++ +YVV G SL V YDP A KW V L V
Sbjct: 378 RFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNA 437
Query: 441 NVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIA 500
V+S K ++ GG + + ++V ++P + W A P AV +I I
Sbjct: 438 AVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIM 497
Query: 501 GGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGF 550
GG TE +AS FD TN+W + + +R S ++ LY +GG+
Sbjct: 498 GGDTE-FTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGY 546
Score = 39.3 bits (90), Expect = 0.011
Identities = 32/151 (21%), Positives = 59/151 (39%), Gaps = 4/151 (2%)
Query: 452 LGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGV-TEDGLSA 510
LGG+T ++++ + K + A + PR F + K+ + GG +E+G+S
Sbjct: 300 LGGQTF---MCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSK 356
Query: 511 SVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWK 570
V +D +W R L LY +GG + + + K
Sbjct: 357 DVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEK 416
Query: 571 YEDDKKEWAGMLKEIRYASGASCLATRLNLF 601
Y+ +W + S A+ ++ +L LF
Sbjct: 417 YDPGANKWMMVAPLRDGVSNAAVVSAKLKLF 447
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 181 bits (460), Expect = 1e-45
Identities = 133/531 (25%), Positives = 231/531 (43%), Gaps = 39/531 (7%)
Query: 30 KKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEA-----KKKEVVLDNVDPAIL 84
K F D + + H+ +L++CS YF++ + ++ +K E+VL N+ +L
Sbjct: 326 KAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVL 385
Query: 85 DLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLL 144
+L+++++Y+ S+ ++ N + + AS+FQ + VCVS+L+K+L NCL +L +
Sbjct: 386 ELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEA 445
Query: 145 LDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWV 204
+ C L A+ F F ++ +E+ + +S + I+ +SNDSLN + EE V+E V+KW+
Sbjct: 446 MQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWI 505
Query: 205 RTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNP---DL---QKKIKVLKDA 258
+ D R + +E+ +R + Y + V+ +++IKS+ DL K+ +L A
Sbjct: 506 KKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHA 565
Query: 259 FAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYD 318
++ G EV VG ++ GM + L+ A ++
Sbjct: 566 RQEMQTPRTRPRLSAGVAEVIVLVGGRQMV----------GMTQRSLV------AVTCWN 609
Query: 319 PTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEW 378
P N+ Y A R S+V+ + IY+ GG+ D + Y LD+ W
Sbjct: 610 PQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLAD--VWCYMSLLDN----W 663
Query: 379 VGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVY 438
+ + RC D KIY + G L ++D V YD + +W V LP V+
Sbjct: 664 NLVSRMTVPRCRHNSLVYDGKIYTLGG--LGVAGNVDHVERYDTITNQWEAVAPLPKAVH 721
Query: 439 GHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIV 498
G IY GG + + + + P+ W + I G +
Sbjct: 722 SAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVF 781
Query: 499 IAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGG 549
I GG + + +D R S V L G +YA GG
Sbjct: 782 ILGG----AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGG 828
Score = 35.0 bits (79), Expect = 0.20
Identities = 27/133 (20%), Positives = 52/133 (39%), Gaps = 13/133 (9%)
Query: 465 VFIFNPKKGDWKDLAPMKI-PRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWD 523
V +NP+ W LA + R F V I ++GG+ A V + + W+
Sbjct: 605 VTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWN 664
Query: 524 VMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEW---AG 580
+++ R + + G +Y +GG + V+ + +Y+ +W A
Sbjct: 665 LVSRMTVPRCRHNSLVYDGKIYTLGGLGV---------AGNVDHVERYDTITNQWEAVAP 715
Query: 581 MLKEIRYASGASC 593
+ K + A+ C
Sbjct: 716 LPKAVHSAAATVC 728
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 181 bits (460), Expect = 1e-45
Identities = 133/531 (25%), Positives = 231/531 (43%), Gaps = 39/531 (7%)
Query: 30 KKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEA-----KKKEVVLDNVDPAIL 84
K F D + + H+ +L++CS YF++ + ++ +K E+VL N+ +L
Sbjct: 326 KAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVL 385
Query: 85 DLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLL 144
+L+++++Y+ S+ ++ N + + AS+FQ + VCVS+L+K+L NCL +L +
Sbjct: 386 ELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEA 445
Query: 145 LDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWV 204
+ C L A+ F F ++ +E+ + +S + I+ +SNDSLN + EE V+E V+KW+
Sbjct: 446 MQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWI 505
Query: 205 RTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNP---DL---QKKIKVLKDA 258
+ D R + +E+ +R + Y + V+ +++IKS+ DL K+ +L A
Sbjct: 506 KKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHA 565
Query: 259 FAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYD 318
++ G EV VG ++ GM + L+ A ++
Sbjct: 566 RQEMQTPRTRPRLSAGVAEVIVLVGGRQMV----------GMTQRSLV------AVTCWN 609
Query: 319 PTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEW 378
P N+ Y A R S+V+ + IY+ GG+ D + Y LD+ W
Sbjct: 610 PQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLAD--VWCYMSLLDN----W 663
Query: 379 VGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVY 438
+ + RC D KIY + G L ++D V YD + +W V LP V+
Sbjct: 664 NLVSRMTVPRCRHNSLVYDGKIYTLGG--LGVAGNVDHVERYDTITNQWEAVAPLPKAVH 721
Query: 439 GHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIV 498
G IY GG + + + + P+ W + I G +
Sbjct: 722 SAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVF 781
Query: 499 IAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGG 549
I GG + + +D R S V L G +YA GG
Sbjct: 782 ILGG----AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGG 828
Score = 35.0 bits (79), Expect = 0.20
Identities = 27/133 (20%), Positives = 52/133 (39%), Gaps = 13/133 (9%)
Query: 465 VFIFNPKKGDWKDLAPMKI-PRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWD 523
V +NP+ W LA + R F V I ++GG+ A V + + W+
Sbjct: 605 VTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWN 664
Query: 524 VMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEW---AG 580
+++ R + + G +Y +GG + V+ + +Y+ +W A
Sbjct: 665 LVSRMTVPRCRHNSLVYDGKIYTLGGLGV---------AGNVDHVERYDTITNQWEAVAP 715
Query: 581 MLKEIRYASGASC 593
+ K + A+ C
Sbjct: 716 LPKAVHSAAATVC 728
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 179 bits (455), Expect = 5e-45
Identities = 128/551 (23%), Positives = 235/551 (42%), Gaps = 77/551 (13%)
Query: 32 FIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPAILDLIIKYL 91
F D L+ G +S HRL+L+A SPYF F + E+ K V + ++ I +++ ++
Sbjct: 36 FCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFI 95
Query: 92 YSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLA 151
Y+ +++ NVQ++ A Q+ V +C +L+ ++ P NC+ I + + C L
Sbjct: 96 YTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLL 155
Query: 152 ISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVRTDKENR 211
+ ++ F+++ E+F+ L+ +LI ++ ++ L++E E VF A M+W+ D R
Sbjct: 156 EFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKR 215
Query: 212 VKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGKLPEPSKNAA 271
K++ EV D IRF L+ + ++E
Sbjct: 216 RKHVVEVLDPIRFPLLPPQRLLKYIE---------------------------------- 241
Query: 272 KTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPTENE-CYLTALA 330
G + N V + LL Y V P EN+ C +
Sbjct: 242 --GVSDFNLRVALQTLLKEY---------------------CEVCKSPKENKFCSFLQTS 278
Query: 331 EQIPRNHSSIVTQQNQIYVVGGLYVDEENK--DQPLQSYFFQLDSIASEWVGLPPLPSAR 388
+ PR + + +Y VGG + + D S + D+ + W + L AR
Sbjct: 279 KVRPRKKA-----RKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQAR 333
Query: 389 CLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGM 448
G+ + +Y + G+ + D CYDPV +W V + G V G
Sbjct: 334 SGLGVTVLGGMVYAIGGE--KDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGA 391
Query: 449 IYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGL 508
IY LGG + N + F+P + W+ + M + R FG +G I + GG++ +G+
Sbjct: 392 IYALGGWV-GAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGI 450
Query: 509 S-ASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVND 567
S E +D + +W + R+ + + +L +Y++GG+ Q ++
Sbjct: 451 ELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ--------DALHT 502
Query: 568 IWKYEDDKKEW 578
+ KY ++++W
Sbjct: 503 VEKYSFEEEKW 513
Score = 70.1 bits (170), Expect = 6e-12
Identities = 51/181 (28%), Positives = 85/181 (46%), Gaps = 12/181 (6%)
Query: 317 YDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIAS 376
+DP EN+ + + R + Q IYV+GG+ N+ L+S F D ++
Sbjct: 410 FDPDENKWEVVGNMA-VSRYYFGCCEMQGLIYVIGGI----SNEGIELRS-FEVYDPLSK 463
Query: 377 EWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIK 436
W LPP+ + R G+ ++D IY V G + +T+ +L +V Y KW EV + +
Sbjct: 464 RWSPLPPMGTRRAYLGVAALNDCIYSVGGWN-ETQDALHTVEKYSFEEEKWVEVASMKVP 522
Query: 437 VYGHNVISHKGMIYCLGGKTDDKK-----CTNRVFIFNPKKGDWKDLAPMKIPRSMFGVA 491
G V++ G++Y GG++ + V ++NP W ++ M R GVA
Sbjct: 523 RAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVA 582
Query: 492 V 492
V
Sbjct: 583 V 583
Score = 50.8 bits (120), Expect = 4e-06
Identities = 51/218 (23%), Positives = 84/218 (38%), Gaps = 18/218 (8%)
Query: 379 VGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKW----NEVKKLP 434
+ P LP R L + V D VA LQT +C P K+ K P
Sbjct: 226 IRFPLLPPQRLLKYIEGVSDFNLRVA---LQTLLKEYCEVCKSPKENKFCSFLQTSKVRP 282
Query: 435 IKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHK 494
K + + G GG+ D + + V F+ W ++ + RS GV V
Sbjct: 283 RKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLG 342
Query: 495 GKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQ 554
G + GG + + E +D T +W + R + + G++YA+GG+ +
Sbjct: 343 GMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAE 402
Query: 555 LESKEFAPTEVNDIWKYEDDKKEW--AGMLKEIRYASG 590
+ N I +++ D+ +W G + RY G
Sbjct: 403 IG---------NTIERFDPDENKWEVVGNMAVSRYYFG 431
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 179 bits (455), Expect = 5e-45
Identities = 128/551 (23%), Positives = 235/551 (42%), Gaps = 77/551 (13%)
Query: 32 FIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPAILDLIIKYL 91
F D L+ G +S HRL+L+A SPYF F + E+ K V + ++ I +++ ++
Sbjct: 36 FCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFI 95
Query: 92 YSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLA 151
Y+ +++ NVQ++ A Q+ V +C +L+ ++ P NC+ I + + C L
Sbjct: 96 YTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLL 155
Query: 152 ISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVRTDKENR 211
+ ++ F+++ E+F+ L+ +LI ++ ++ L++E E VF A M+W+ D R
Sbjct: 156 EFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKR 215
Query: 212 VKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGKLPEPSKNAA 271
K++ EV D IRF L+ + ++E
Sbjct: 216 RKHVVEVLDPIRFPLLPPQRLLKYIE---------------------------------- 241
Query: 272 KTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPTENE-CYLTALA 330
G + N V + LL Y V P EN+ C +
Sbjct: 242 --GVSDFNLRVALQTLLKEY---------------------CEVCKSPKENKFCSFLQTS 278
Query: 331 EQIPRNHSSIVTQQNQIYVVGGLYVDEENK--DQPLQSYFFQLDSIASEWVGLPPLPSAR 388
+ PR + + +Y VGG + + D S + D+ + W + L AR
Sbjct: 279 KVRPRKKA-----RKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQAR 333
Query: 389 CLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGM 448
G+ + +Y + G+ + D CYDPV +W V + G V G
Sbjct: 334 SGLGVTVLGGMVYAIGGE--KDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGA 391
Query: 449 IYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGL 508
IY LGG + N + F+P + W+ + M + R FG +G I + GG++ +G+
Sbjct: 392 IYALGGWV-GAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGI 450
Query: 509 S-ASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVND 567
S E +D + +W + R+ + + +L +Y++GG+ Q ++
Sbjct: 451 ELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ--------DALHT 502
Query: 568 IWKYEDDKKEW 578
+ KY ++++W
Sbjct: 503 VEKYSFEEEKW 513
Score = 50.8 bits (120), Expect = 4e-06
Identities = 51/218 (23%), Positives = 84/218 (38%), Gaps = 18/218 (8%)
Query: 379 VGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKW----NEVKKLP 434
+ P LP R L + V D VA LQT +C P K+ K P
Sbjct: 226 IRFPLLPPQRLLKYIEGVSDFNLRVA---LQTLLKEYCEVCKSPKENKFCSFLQTSKVRP 282
Query: 435 IKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHK 494
K + + G GG+ D + + V F+ W ++ + RS GV V
Sbjct: 283 RKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLG 342
Query: 495 GKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQ 554
G + GG + + E +D T +W + R + + G++YA+GG+ +
Sbjct: 343 GMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAE 402
Query: 555 LESKEFAPTEVNDIWKYEDDKKEW--AGMLKEIRYASG 590
+ N I +++ D+ +W G + RY G
Sbjct: 403 IG---------NTIERFDPDENKWEVVGNMAVSRYYFG 431
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,440,049
Number of Sequences: 37866
Number of extensions: 991516
Number of successful extensions: 3434
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 141
Number of HSP's successfully gapped in prelim test: 53
Number of HSP's that attempted gapping in prelim test: 2433
Number of HSP's gapped (non-prelim): 471
length of query: 606
length of database: 18,247,518
effective HSP length: 108
effective length of query: 498
effective length of database: 14,157,990
effective search space: 7050679020
effective search space used: 7050679020
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.