Search of human proteins with 39812447

Search of human proteins with 39812447

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|39812447 3-oxo-5 alpha-steroid 4-dehydrogenase 2 [Homo
sapiens]
         (254 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|39812447 3-oxo-5 alpha-steroid 4-dehydrogenase 2 [Homo sapiens]    525   e-149
gi|4507201 steroid-5-alpha-reductase 1 [Homo sapiens]                 238   4e-63
gi|24475816 glycoprotein, synaptic 2 [Homo sapiens]                    63   2e-10
gi|239751670 PREDICTED: similar to hCG16318 [Homo sapiens]             62   4e-10
gi|13375785 steroid 5 alpha-reductase 3 [Homo sapiens]                 61   1e-09
gi|58332438 steroid 5 alpha-reductase 2-like 2 [Homo sapiens]          46   4e-05
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p...    34   0.14 
gi|239749777 PREDICTED: hypothetical protein [Homo sapiens]            29   4.5  
gi|239744036 PREDICTED: hypothetical protein XP_002343022 [Homo ...    29   4.5  
gi|126116581 retina and anterior neural fold homeobox [Homo sapi...    29   4.5  
gi|25952144 tumor necrosis factor ligand superfamily, member 14 ...    28   5.9  
gi|109689695 transient receptor potential cation channel, subfam...    28   7.7  

>gi|39812447 3-oxo-5 alpha-steroid 4-dehydrogenase 2 [Homo sapiens]
          Length = 254

 Score =  525 bits (1352), Expect = e-149
 Identities = 254/254 (100%), Positives = 254/254 (100%)

Query: 1   MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS 60
           MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS
Sbjct: 1   MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS 60

Query: 61  FAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCT 120
           FAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCT
Sbjct: 61  FAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCT 120

Query: 121 GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI 180
           GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI
Sbjct: 121 GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI 180

Query: 181 PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE 240
           PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE
Sbjct: 181 PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE 240

Query: 241 DYPKSRKALIPFIF 254
           DYPKSRKALIPFIF
Sbjct: 241 DYPKSRKALIPFIF 254


>gi|4507201 steroid-5-alpha-reductase 1 [Homo sapiens]
          Length = 259

 Score =  238 bits (607), Expect = 4e-63
 Identities = 119/226 (52%), Positives = 150/226 (66%), Gaps = 4/226 (1%)

Query: 31  SGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLS-LFGPPGTVLLGLFCL 89
           S YG+H  +L     R+PARAAW +QELPS A+P    A +    L   P  +LL +F +
Sbjct: 36  SVYGRH--ALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLV 93

Query: 90  HYFHRTFVYSLLNRG-RPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSL 148
           HY HR  +Y  L RG +P P +       FCT NG LQ  YL +CA Y D W TD RF +
Sbjct: 94  HYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLI 153

Query: 149 GVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALAT 208
           G  L++ GM INIHSD+ILR LRKPG+  Y+IP+GGLF YV+ AN+ GEI+EW GYALA+
Sbjct: 154 GFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALAS 213

Query: 209 WSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF 254
           WS+   AFAFF+ CFL  RA  HH +YL+ FE+YPK RK +IPF+F
Sbjct: 214 WSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF 259


>gi|24475816 glycoprotein, synaptic 2 [Homo sapiens]
          Length = 308

 Score = 63.2 bits (152), Expect = 2e-10
 Identities = 44/149 (29%), Positives = 66/149 (44%), Gaps = 9/149 (6%)

Query: 112 ILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTD-IRFSLGVFLFILGMGINIHSDYILRQL 170
           I +   +  G      YY+ +    P  +    ++ +L +F+       +IH    LR L
Sbjct: 161 IFKNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQLGNFSIHM--ALRDL 218

Query: 171 RKPGEISYRIPQGG------LFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFL 224
           R  G  + +IP         LF  VS  N+  E+  WIG+A+ T  LP   F+      +
Sbjct: 219 RPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQM 278

Query: 225 GLRAFHHHRFYLKMFEDYPKSRKALIPFI 253
            + A   HR YLK F DYP  R  +IPF+
Sbjct: 279 TIWAKGKHRSYLKEFRDYPPLRMPIIPFL 307


>gi|239751670 PREDICTED: similar to hCG16318 [Homo sapiens]
          Length = 166

 Score = 62.4 bits (150), Expect = 4e-10
 Identities = 44/156 (28%), Positives = 68/156 (43%), Gaps = 9/156 (5%)

Query: 105 RPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTD-IRFSLGVFLFILGMGINIHS 163
           + +P     +   +  G      YY+ +    P  +    ++ +L +F+       +IH 
Sbjct: 12  KSHPCPAPFQNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQLGNFSIHM 71

Query: 164 DYILRQLRKPGEISYRIPQGG------LFTYVSGANFLGEIIEWIGYALATWSLPALAFA 217
              LR LR  G  + +IP         LF  VS  N+  E+  WIG+A+ T  LP   F+
Sbjct: 72  --ALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFS 129

Query: 218 FFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFI 253
                 + + A   HR YLK F DYP  R  +IPF+
Sbjct: 130 LVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFL 165


>gi|13375785 steroid 5 alpha-reductase 3 [Homo sapiens]
          Length = 318

 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 42/118 (35%), Positives = 57/118 (48%), Gaps = 15/118 (12%)

Query: 148 LGVFLFILGMGINIHSDYILRQLRKPG-----EISYRIPQGGLFTYVSGANFLGEIIEWI 202
           LG+ +FI           IL  LRK         ++RIP G  F YVS  N+L E++ ++
Sbjct: 205 LGMMMFIWSSAHQYKCHVILGNLRKNKAGVVIHCNHRIPFGDWFEYVSSPNYLAELMIYV 264

Query: 203 GYALA------TWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF 254
             A+       TW L  +   FF+     L AF  H+FY   F  YPK RKA +PF+F
Sbjct: 265 SMAVTFGFHNLTWWL-VVTNVFFNQA---LSAFLSHQFYKSKFVSYPKHRKAFLPFLF 318


>gi|58332438 steroid 5 alpha-reductase 2-like 2 [Homo sapiens]
          Length = 363

 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 24/69 (34%), Positives = 34/69 (49%)

Query: 185 LFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPK 244
           +F  VS  N+  EI  WI + + T +LP   F       + L A   H+ YL+ F  Y  
Sbjct: 294 MFFLVSCPNYTYEIGSWISFTVMTQTLPVGIFTLLMSIQMSLWAQKKHKIYLRKFNSYIH 353

Query: 245 SRKALIPFI 253
            + A+IPFI
Sbjct: 354 RKSAMIPFI 362


>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 4 [Homo sapiens]
          Length = 1203

 Score = 33.9 bits (76), Expect = 0.14
 Identities = 15/50 (30%), Positives = 26/50 (52%)

Query: 30  PSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPP 79
           PS  G  + +  P+    P+ +++ +Q+L  F+ PAG+    P S   PP
Sbjct: 834 PSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPAGLSPLLPSSSSSPP 883


>gi|239749777 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 686

 Score = 28.9 bits (63), Expect = 4.5
 Identities = 27/75 (36%), Positives = 31/75 (41%), Gaps = 9/75 (12%)

Query: 49  ARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRG---R 105
           A AA F  +  SF      L  QPL LF P  T     FC    HR F+     R     
Sbjct: 339 AAAAAFCPQSHSFLPSPPRLFAQPLQLFAPEATP----FCPR--HRGFLRHFTPRRCGFL 392

Query: 106 PYPAILILRGTAFCT 120
           P P +LI    AFC+
Sbjct: 393 PPPQLLIPIAVAFCS 407


>gi|239744036 PREDICTED: hypothetical protein XP_002343022 [Homo
           sapiens]
          Length = 686

 Score = 28.9 bits (63), Expect = 4.5
 Identities = 27/75 (36%), Positives = 31/75 (41%), Gaps = 9/75 (12%)

Query: 49  ARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRG---R 105
           A AA F  +  SF      L  QPL LF P  T     FC    HR F+     R     
Sbjct: 339 AAAAAFCPQSHSFLPSPPRLFAQPLQLFAPEATP----FCPR--HRGFLRHFTPRRCGFL 392

Query: 106 PYPAILILRGTAFCT 120
           P P +LI    AFC+
Sbjct: 393 PPPQLLIPIAVAFCS 407


>gi|126116581 retina and anterior neural fold homeobox [Homo
           sapiens]
          Length = 346

 Score = 28.9 bits (63), Expect = 4.5
 Identities = 32/83 (38%), Positives = 37/83 (44%), Gaps = 12/83 (14%)

Query: 3   VQCQQSPVLA-----GSATLVALGALALYVAKPSGYGKHTES-LKPAATRLPARAAWFLQ 56
           ++ Q SP+L+      SATL  LGA       P+G     ES L P    LP   A  LQ
Sbjct: 202 MKLQDSPLLSFSRSPPSATLSPLGAGPGSGGGPAGGALPLESWLGPP---LPGGGATALQ 258

Query: 57  ELPSFAVPAGILARQPLSLFGPP 79
            LP F  PA  L   P S   PP
Sbjct: 259 SLPGFGPPAQSL---PASYTPPP 278


>gi|25952144 tumor necrosis factor ligand superfamily, member 14
           isoform 1 precursor [Homo sapiens]
          Length = 240

 Score = 28.5 bits (62), Expect = 5.9
 Identities = 12/39 (30%), Positives = 23/39 (58%)

Query: 145 RFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQG 183
           R  LG+ L ++G G+ +   ++L+   + GE+  R+P G
Sbjct: 37  RVGLGLLLLLMGAGLAVQGWFLLQLHWRLGEMVTRLPDG 75


>gi|109689695 transient receptor potential cation channel, subfamily
           M, member 8 [Homo sapiens]
          Length = 1104

 Score = 28.1 bits (61), Expect = 7.7
 Identities = 20/70 (28%), Positives = 33/70 (47%), Gaps = 4/70 (5%)

Query: 96  FVYSLLN--RGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLF 153
           F Y LL      P+P  L+L    F      ++ +Y+     + D W  ++  +LG+F F
Sbjct: 752 FAYVLLMDFHSVPHPPELVLYSLVFVLFCDEVRQWYVNGVNYFTDLW--NVMDTLGLFYF 809

Query: 154 ILGMGINIHS 163
           I G+   +HS
Sbjct: 810 IAGIVFRLHS 819


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.330    0.146    0.473 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,582,993
Number of Sequences: 37866
Number of extensions: 519468
Number of successful extensions: 1218
Number of sequences better than 10.0: 12
Number of HSP's better than 10.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1206
Number of HSP's gapped (non-prelim): 13
length of query: 254
length of database: 18,247,518
effective HSP length: 100
effective length of query: 154
effective length of database: 14,460,918
effective search space: 2226981372
effective search space used: 2226981372
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.