Search of human proteins with 39725938

Search of human proteins with 39725938

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|39725938 polymerase (RNA) III (DNA directed) polypeptide A,
155kDa [Homo sapiens]
         (1390 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|39725938 polymerase (RNA) III (DNA directed) polypeptide A, 1...  2783   0.0  
gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]            571   e-162
gi|103471997 DNA-directed RNA polymerase I A [Homo sapiens]           403   e-112
gi|4507467 transforming growth factor, beta-induced, 68kDa precu...    34   0.86 
gi|154146189 dedicator of cytokinesis 10 [Homo sapiens]                34   1.1  
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo...    31   7.2  
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo...    31   7.2  
gi|56549696 E1A binding protein p400 [Homo sapiens]                    31   7.2  

>gi|39725938 polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
            [Homo sapiens]
          Length = 1390

 Score = 2783 bits (7214), Expect = 0.0
 Identities = 1390/1390 (100%), Positives = 1390/1390 (100%)

Query: 1    MVKEQFRETDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNQHAPLLYGVLDHRM 60
            MVKEQFRETDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNQHAPLLYGVLDHRM
Sbjct: 1    MVKEQFRETDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNQHAPLLYGVLDHRM 60

Query: 61   GTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAVIGILQMICKTCCHIMLSQE 120
            GTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAVIGILQMICKTCCHIMLSQE
Sbjct: 61   GTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAVIGILQMICKTCCHIMLSQE 120

Query: 121  EKKQFLDYLKRPGLTYLQKRGLKKKISDKCRKKNICHHCGAFNGTVKKCGLLKIIHEKYK 180
            EKKQFLDYLKRPGLTYLQKRGLKKKISDKCRKKNICHHCGAFNGTVKKCGLLKIIHEKYK
Sbjct: 121  EKKQFLDYLKRPGLTYLQKRGLKKKISDKCRKKNICHHCGAFNGTVKKCGLLKIIHEKYK 180

Query: 181  TNKKVVDPIVSNFLQSFETAIEHNKEVEPLLGRAQENLNPLVVLNLFKRIPAEDVPLLLM 240
            TNKKVVDPIVSNFLQSFETAIEHNKEVEPLLGRAQENLNPLVVLNLFKRIPAEDVPLLLM
Sbjct: 181  TNKKVVDPIVSNFLQSFETAIEHNKEVEPLLGRAQENLNPLVVLNLFKRIPAEDVPLLLM 240

Query: 241  NPEAGKPSDLILTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISG 300
            NPEAGKPSDLILTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISG
Sbjct: 241  NPEAGKPSDLILTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISG 300

Query: 301  AKTQMIMEDWDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGKR 360
            AKTQMIMEDWDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGKR
Sbjct: 301  AKTQMIMEDWDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGKR 360

Query: 361  VDFSGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVQNGPEVHPGANF 420
            VDFSGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVQNGPEVHPGANF
Sbjct: 361  VDFSGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVQNGPEVHPGANF 420

Query: 421  IQQRHTQMKRFLKYGNREKMAQELKYGDIVERHLIDGDVVLFNRQPSLHKLSIMAHLARV 480
            IQQRHTQMKRFLKYGNREKMAQELKYGDIVERHLIDGDVVLFNRQPSLHKLSIMAHLARV
Sbjct: 421  IQQRHTQMKRFLKYGNREKMAQELKYGDIVERHLIDGDVVLFNRQPSLHKLSIMAHLARV 480

Query: 481  KPHRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIA 540
            KPHRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIA
Sbjct: 481  KPHRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIA 540

Query: 541  AIQDFLTGAYLLTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQI 600
            AIQDFLTGAYLLTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQI
Sbjct: 541  AIQDFLTGAYLLTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQI 600

Query: 601  FSVILRPSDDNPVRANLRTKGKQYCGKGEDLCANDSYVTIQNSELMSGSMDKGTLGSGSK 660
            FSVILRPSDDNPVRANLRTKGKQYCGKGEDLCANDSYVTIQNSELMSGSMDKGTLGSGSK
Sbjct: 601  FSVILRPSDDNPVRANLRTKGKQYCGKGEDLCANDSYVTIQNSELMSGSMDKGTLGSGSK 660

Query: 661  NNIFYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKAKYELLNAG 720
            NNIFYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKAKYELLNAG
Sbjct: 661  NNIFYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKAKYELLNAG 720

Query: 721  YKKCDEYIEALNTGKLQQQPGCTAEETLEALILKELSVIRDHAGSACLRELDKSNSPLTM 780
            YKKCDEYIEALNTGKLQQQPGCTAEETLEALILKELSVIRDHAGSACLRELDKSNSPLTM
Sbjct: 721  YKKCDEYIEALNTGKLQQQPGCTAEETLEALILKELSVIRDHAGSACLRELDKSNSPLTM 780

Query: 781  ALCGSKGSFINISQMIACVGQQAISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYS 840
            ALCGSKGSFINISQMIACVGQQAISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYS
Sbjct: 781  ALCGSKGSFINISQMIACVGQQAISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYS 840

Query: 841  GLTPTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQF 900
            GLTPTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQF
Sbjct: 841  GLTPTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQF 900

Query: 901  IYGGDGLDPAAMEGKDEPLEFKRVLDNIKAVFPCPSEPALSKNELILTTESIMKKSEFLC 960
            IYGGDGLDPAAMEGKDEPLEFKRVLDNIKAVFPCPSEPALSKNELILTTESIMKKSEFLC
Sbjct: 901  IYGGDGLDPAAMEGKDEPLEFKRVLDNIKAVFPCPSEPALSKNELILTTESIMKKSEFLC 960

Query: 961  CQDSFLQEIKKFIKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQVEKFLETCRD 1020
            CQDSFLQEIKKFIKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQVEKFLETCRD
Sbjct: 961  CQDSFLQEIKKFIKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQVEKFLETCRD 1020

Query: 1021 KYMRAQMEPGSAVGALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASKAI 1080
            KYMRAQMEPGSAVGALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASKAI
Sbjct: 1021 KYMRAQMEPGSAVGALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASKAI 1080

Query: 1081 STPIITAQLDKDDDADYARLVKGRIEKTLLGEISEYIEEVFLPDDCFILVKLSLERIRLL 1140
            STPIITAQLDKDDDADYARLVKGRIEKTLLGEISEYIEEVFLPDDCFILVKLSLERIRLL
Sbjct: 1081 STPIITAQLDKDDDADYARLVKGRIEKTLLGEISEYIEEVFLPDDCFILVKLSLERIRLL 1140

Query: 1141 RLEVNAETVRYSICTSKLRVKPGDVAVHGEAVVCVTPRENSKSSMYYVLQFLKEDLPKVV 1200
            RLEVNAETVRYSICTSKLRVKPGDVAVHGEAVVCVTPRENSKSSMYYVLQFLKEDLPKVV
Sbjct: 1141 RLEVNAETVRYSICTSKLRVKPGDVAVHGEAVVCVTPRENSKSSMYYVLQFLKEDLPKVV 1200

Query: 1201 VQGIPEVSRAVIHIDEQSGKEKYKLLVEGDNLRAVMATHGVKGTRTTSNNTYEVEKTLGI 1260
            VQGIPEVSRAVIHIDEQSGKEKYKLLVEGDNLRAVMATHGVKGTRTTSNNTYEVEKTLGI
Sbjct: 1201 VQGIPEVSRAVIHIDEQSGKEKYKLLVEGDNLRAVMATHGVKGTRTTSNNTYEVEKTLGI 1260

Query: 1261 EAARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLMLAS 1320
            EAARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLMLAS
Sbjct: 1261 EAARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLMLAS 1320

Query: 1321 FEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLFKLLHKADRDPNPPKRPLIFD 1380
            FEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLFKLLHKADRDPNPPKRPLIFD
Sbjct: 1321 FEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLFKLLHKADRDPNPPKRPLIFD 1380

Query: 1381 TNEFHIPLVT 1390
            TNEFHIPLVT
Sbjct: 1381 TNEFHIPLVT 1390


>gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]
          Length = 1970

 Score =  571 bits (1471), Expect = e-162
 Identities = 350/910 (38%), Positives = 519/910 (57%), Gaps = 32/910 (3%)

Query: 13  KKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNQHA-PLLYGVLDHRMGTSEKDRPCET 71
           + I  + FG+ SP+E+++ +  +   K  Y +  +   P L G++D R G  E+   C+T
Sbjct: 16  RTIKRVQFGVLSPDELKRMSVTEGGIK--YPETTEGGRPKLGGLMDPRQGVIERTGRCQT 73

Query: 72  CGKNLADCLGHYGYIDLELPCFHVGYFRAVIGILQMICKTCCHIMLSQEEKKQFLDYLKR 131
           C  N+ +C GH+G+I+L  P FHVG+    + +L+ +C  C  +++     K   D L +
Sbjct: 74  CAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVDSNNPK-IKDILAK 132

Query: 132 PGLTYLQKRGLKKK----ISDKCRKKNICHHCGAFNGTVKKCGLLKIIHEKYKTNKKVVD 187
                   +G  KK    + D C+ KNIC      +    K G+ +   ++  T +K   
Sbjct: 133 -------SKGQPKKRLTHVYDLCKGKNICEGGEEMDN---KFGVEQPEGDEDLTKEKGHG 182

Query: 188 PIVSNFLQSFETAIEHNKEVEPLLGRAQEN---LNPLVVLNLFKRIPAEDVPLLLMNPEA 244
                  +   + +E   E + +   +QE    L+P  V  +FKRI  E+  +L M P  
Sbjct: 183 GCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEPRY 242

Query: 245 GKPSDLILTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISGAKTQ 304
            +P  +I+T L VPPL +RP+VV    S  N+DDLT KL +I+ +N+ ++++  +GA   
Sbjct: 243 ARPEWMIVTVLPVPPLSVRPAVVMQ-GSARNQDDLTHKLADIVKINNQLRRNEQNGAAAH 301

Query: 305 MIMEDWDFLQLQCALYINSELSGIPLNMAPK-KWTRGFVQRLKGKQGRFRGNLSGKRVDF 363
           +I ED   LQ   A  +++EL G+P  M    +  +   QRLKGK+GR RGNL GKRVDF
Sbjct: 302 VIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVDF 361

Query: 364 SGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVQNGPEVHPGANFIQQ 423
           S RTVI+PDPNL ID+V VP  +A  +TF E V   NI+ L++LV+ G   +PGA +I  
Sbjct: 362 SARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII- 420

Query: 424 RHTQMKRFLKYGNREKMAQELKYGDIVERHLIDGDVVLFNRQPSLHKLSIMAHLARVKPH 483
           R    +  L++ + +     L+ G  VERH+ DGD+V+FNRQP+LHK+S+M H  R+ P 
Sbjct: 421 RDNGDRIDLRF-HPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPW 479

Query: 484 RTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIAAIQ 543
            TFR N  V TPYNADFDGDEMNLHLPQ+ E +AE   L      +VTP++  P++  +Q
Sbjct: 480 STFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQ 539

Query: 544 DFLTGAYLLTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQIFSV 603
           D LT     T +D F +R +   ++   L   D K+    P P ILKP  LWTGKQIFS+
Sbjct: 540 DTLTAVRKFTKRDVFLERGEVMNLLM-FLSTWDGKV----PQPAILKPRPLWTGKQIFSL 594

Query: 604 ILRPSDDNPVRANLRTKGKQYCGKGEDLCANDSYVTIQNSELMSGSMDKGTLGSGSKNNI 663
           I+ P   N +R +      +  G  + +   D+ V ++N EL+ G + K +LG+ S  ++
Sbjct: 595 II-PGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGT-SAGSL 652

Query: 664 FYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKAKYELLNAGYKK 723
            +I   + G +      S +  +   +L   G +IGIGD        +     +    + 
Sbjct: 653 VHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQD 712

Query: 724 CDEYIEALNTGKLQQQPGCTAEETLEALILKELSVIRDHAGSACLRELDKSNSPLTMALC 783
             E IE  +  +L+  PG T  +T E  + + L+  RD  GS+  + L + N+  +M + 
Sbjct: 713 VIEVIEKAHNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVS 772

Query: 784 GSKGSFINISQMIACVGQQAISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYSGLT 843
           G+KGS INISQ+IA VGQQ + G R+P GF++R+LPHF K    P ++GFV NS+ +GLT
Sbjct: 773 GAKGSKINISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLT 832

Query: 844 PTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQFIYG 903
           PTEFFFH M GREGL+DTAVKTAETGY+QRRL+KS+E +  +YD TVR+S   ++Q  YG
Sbjct: 833 PTEFFFHAMGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYG 892

Query: 904 GDGLDPAAME 913
            DGL   ++E
Sbjct: 893 EDGLAGESVE 902



 Score =  177 bits (450), Expect = 5e-44
 Identities = 136/439 (30%), Positives = 210/439 (47%), Gaps = 57/439 (12%)

Query: 987  YGINDNGTTEPRVLYQLDRITPTQVEKFLETCRDKYMRAQMEPGSAVGALCAQSIGEPGT 1046
            + I+   T   R + +  R++    +  L     K+ +A   PG  VGAL AQS+GEP T
Sbjct: 1041 FNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPAT 1100

Query: 1047 QMTLKTFHFAGVASMNITLGVPRIKEIINASKAISTPIITAQL--DKDDDADYARLVKGR 1104
            QMTL TFH+AGV++ N+TLGVPR+KE+IN SK   TP +T  L      DA+ A+ +  R
Sbjct: 1101 QMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERAKDILCR 1160

Query: 1105 IEKTLLGEIS--------------------EYIEEVF-LPDDCFILVKLSLERIRLLRLE 1143
            +E T L +++                    E++   + +PD     +   L R+ L R  
Sbjct: 1161 LEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMPDFDVARISPWLLRVELDRKH 1220

Query: 1144 VNAETVRYSICTSKLRVKPGDVAV------HGEAVVC----VTPRENSKSSMYYVLQFLK 1193
            +    +       K+    GD         + E +V     +   EN       V+  + 
Sbjct: 1221 MTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIMNSDENKMQEEEEVVDKMD 1280

Query: 1194 ED----------LPKVVVQGIPEVSRAVIHIDEQSGKEK--------YKLLVE------G 1229
            +D          L  + +QGI ++S+  +H+ +   K+K        +K L E      G
Sbjct: 1281 DDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKALQEWILETDG 1340

Query: 1230 DNLRAVMATHGVKGTRTTSNNTYEVEKTLGIEAARTTIINEIQYTMVNHGMSIDRRHVML 1289
             +L  V++   V   RTTSN+  E+   LGIEA R  +  E+ + +   G  ++ RH+ L
Sbjct: 1341 VSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALERELYHVISFDGSYVNYRHLAL 1400

Query: 1290 LSDLMTYKGEVLGITRFGLAKMKESVLMLASFEKTADHLFDAAYFGQKDSVCGVSECIIM 1349
            L D MT +G ++ ITR G+ +     LM  SFE+T D L +AA  G+ D + GVSE I++
Sbjct: 1401 LCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIML 1460

Query: 1350 GIPMNIGTGLFKLLHKADR 1368
            G     GTG F LL  A++
Sbjct: 1461 GQLAPAGTGCFDLLLDAEK 1479


>gi|103471997 DNA-directed RNA polymerase I A [Homo sapiens]
          Length = 1720

 Score =  403 bits (1035), Expect = e-112
 Identities = 296/927 (31%), Positives = 444/927 (47%), Gaps = 137/927 (14%)

Query: 310  WDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGKRVDFSGRTVI 369
            W  LQ    +  +SE+  + ++  P     G  Q L+ K+G FR ++ GKRVD++ R+VI
Sbjct: 391  WIRLQSHVNIVFDSEMDKLMMDKYP-----GIRQILEKKEGLFRKHMMGKRVDYAARSVI 445

Query: 370  SPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVQNGPEVHPGANFI-------- 421
             PD  +  +E+ +P+  A  LT+P+ V   N+  LR+ V NGP VHPGA+ +        
Sbjct: 446  CPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQELRQAVINGPNVHPGASMVINEDGSRT 505

Query: 422  -------QQRHTQMKRFLKYGNREKMAQELKYGDIVERHLIDGDVVLFNRQPSLHKLSIM 474
                    QR    K+ L         Q  K   IV RH+ +GD++L NRQP+LH+ SI 
Sbjct: 506  ALSAVDMTQREAVAKQLLTPATGAPKPQGTK---IVCRHVKNGDILLLNRQPTLHRPSIQ 562

Query: 475  AHLARVKPH-RTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPR 533
            AH AR+ P  +  R +   C  YNADFDGDEMN H PQ+E  +AEA VL  T    + P+
Sbjct: 563  AHRARILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQSELGRAEAYVLACTDQQYLVPK 622

Query: 534  NGEPLIAAIQDFLTGAYLLTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPTILKPVT 593
            +G+PL   IQD +     +T +  FF R    +++   L   D+  +V+L  P+ILKP  
Sbjct: 623  DGQPLAGLIQDHMVSGASMTTRGCFFTREHYMELVYRGLT--DKVGRVKLLSPSILKPFP 680

Query: 594  LWTGKQIFSVIL---RPSDDNPVRANLRTK--GKQYCGK---------GEDLCANDSYVT 639
            LWTGKQ+ S +L    P D  P+  + + K  GK +  +          + +C  +S V 
Sbjct: 681  LWTGKQVVSTLLINIIPEDHIPLNLSGKAKITGKAWVKETPRSVPGFNPDSMC--ESQVI 738

Query: 640  IQNSELMSGSMDKGTLGSGSKNNIFYILLRDWGQNEAADAMSRLARLAPVYLS-NRGFSI 698
            I+  EL+ G +DK   GS S   + +     +G   +   ++ LARL   YL   RGF++
Sbjct: 739  IREGELLCGVLDKAHYGS-SAYGLVHCCYEIYGGETSGKVLTCLARLFTAYLQLYRGFTL 797

Query: 699  GIGDVTP------------------GQGLLKAKYELLN-AGYKKCDEYIEALNTGKLQQQ 739
            G+ D+                    G   ++A   L   A Y +     +  + GK Q+ 
Sbjct: 798  GVEDILVKPKADVKRQRIIEESTHCGPQAVRAALNLPEAASYDEVRGKWQDAHLGKDQRD 857

Query: 740  PGCTAEETLEALILKELSVIRDHAGSAC----LRELDKSNSPLTMALCGSKGSFINISQM 795
                    ++    +E++   +    AC    L      NS   M   G+KGS +N  Q+
Sbjct: 858  -----FNMIDLKFKEEVNHYSNEINKACMPFGLHRQFPENSLQMMVQSGAKGSTVNTMQI 912

Query: 796  IACVGQQAISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYSGLTPTEFFFHTMAGR 855
               +GQ  + G R P     +SLP FE +   P A GFV   F +G+ P EFFFH MAGR
Sbjct: 913  SCLLGQIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIKPPEFFFHCMAGR 972

Query: 856  EGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQFIYGGDGLDPAAMEGK 915
            EGLVDTAVKT+ +GY+QR ++K LE L  QYDLTVR S G ++QF+YG DGLD    +  
Sbjct: 973  EGLVDTAVKTSRSGYLQRCIIKHLEGLVVQYDLTVRDSDGSVVQFLYGEDGLDIPKTQFL 1032

Query: 916  DEPLEFKRVLDNIKAVFPCP--------SEPALSKNELILTTESIMKKSEFLCCQDSFLQ 967
             +P +F  +  N + +            ++P  + +      +   K    L  + +FL 
Sbjct: 1033 -QPKQFPFLASNYEVIMKSQHLHEVLSRADPKKALHHFRAIKKWQSKHPNTLLRRGAFLS 1091

Query: 968  EIKKFIKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQVEKFLETCRD------- 1020
              +K  + V     ++ ++ G +       R+ Y+LD  +  + +K    C D       
Sbjct: 1092 YSQKIQEAVKALKLESENRNGRSPGTQEMLRMWYELDEESRRKYQKKAAACPDPSLSVWR 1151

Query: 1021 -----------------------------KYMRAQM------------------EPGSAV 1033
                                          Y ++++                  EPG AV
Sbjct: 1152 PDIYFASVSETFETKVDDYSQEWAAQTEKSYEKSELSLDRLRTLLQLKWQRSLCEPGEAV 1211

Query: 1034 GALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIIN-ASKAISTPIITAQ-LDK 1091
            G L AQSIGEP TQMTL TFHFAG   MN+TLG+PR++EI+  AS  I TP+++   L+ 
Sbjct: 1212 GLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMVASANIKTPMMSVPVLNT 1271

Query: 1092 DDDADYARLVKGRIEKTLLGEISEYIE 1118
                   + +K ++ +  LGE+ + I+
Sbjct: 1272 KKALKRVKSLKKQLTRVCLGEVLQKID 1298



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 50/165 (30%), Positives = 83/165 (50%), Gaps = 3/165 (1%)

Query: 1200 VVQGIPEVSRAVIHIDEQSGKEKYKLL-VEGDNLRAVMATHGVKGTRTT-SNNTYEVEKT 1257
            V+     ++R +++    +  EK  +L  EG NL  +     V   R   SN+ + +  T
Sbjct: 1552 VIYATKGITRCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLDLRRLYSNDIHAIANT 1611

Query: 1258 LGIEAARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLM 1317
             GIEAA   I  EI+     +G+++D RH+ L++D M ++G    + RFG+ +   S L 
Sbjct: 1612 YGIEAALRVIEKEIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGI-RSNSSPLQ 1670

Query: 1318 LASFEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLFKL 1362
              +FE +   L  A   G  D +   S C+++G  +  GTGLF+L
Sbjct: 1671 QMTFETSFQFLKQATMLGSHDELRSPSACLVVGKVVRGGTGLFEL 1715



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 27/100 (27%), Positives = 54/100 (54%), Gaps = 2/100 (2%)

Query: 13  KKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNQHAPLLYGVLDHRMGTSEKDRPCETC 72
           +++  I FGM S EE+++ + ++ ++   Y  D+   P   G+ D  +G ++    C TC
Sbjct: 10  RRLQGISFGMYSAEELKKLS-VKSITNPRYL-DSLGNPSANGLYDLALGPADSKEVCSTC 67

Query: 73  GKNLADCLGHYGYIDLELPCFHVGYFRAVIGILQMICKTC 112
            ++ ++C GH G+I+L L  ++   F  +  +L+  C  C
Sbjct: 68  VQDFSNCSGHLGHIELPLTVYNPLLFDKLYLLLRGSCLNC 107


>gi|4507467 transforming growth factor, beta-induced, 68kDa
           precursor [Homo sapiens]
          Length = 683

 Score = 34.3 bits (77), Expect = 0.86
 Identities = 40/174 (22%), Positives = 70/174 (40%), Gaps = 23/174 (13%)

Query: 157 HHCGAFNGTVKKCGLLKIIHEKYKTNKKVVDPIVSNFLQSFETAIEHNKEVEPLLGR-AQ 215
           HH      TV    LLK  H        ++D ++S    + +  IE     E L    A 
Sbjct: 203 HHYPNGIVTVNCARLLKADHHATNGVVHLIDKVISTITNNIQQIIEIEDTFETLRAAVAA 262

Query: 216 ENLNPLVVLN-----------LFKRIPAEDVPLLLMNPEAGKPSDLILTRLLVPPLCIRP 264
             LN ++  N            F++IP+E +  +L +PEA +  DL+   +L   +C   
Sbjct: 263 SGLNTMLEGNGQYTLLAPTNEAFEKIPSETLNRILGDPEALR--DLLNNHILKSAMCAEA 320

Query: 265 SVV---------SDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISGAKTQMIMED 309
            V          + L+ G + D LT+    II   D++  + +     ++++ D
Sbjct: 321 IVAGLSVETLEGTTLEVGCSGDMLTINGKAIISNKDILATNGVIHYIDELLIPD 374


>gi|154146189 dedicator of cytokinesis 10 [Homo sapiens]
          Length = 2186

 Score = 33.9 bits (76), Expect = 1.1
 Identities = 54/241 (22%), Positives = 94/241 (39%), Gaps = 52/241 (21%)

Query: 119  QEEKKQFLDYLKRPGLTYLQK--RGLKKKISDKCRKKNICHHCGAFNGTVKKCGLLKIIH 176
            +EE K+++   K P LT L +  + L K  +DK    N+                 KII 
Sbjct: 1890 EEEGKEYI--YKEPKLTGLSEISQRLLKLYADKFGADNV-----------------KIIQ 1930

Query: 177  EKYKTNKKVVDPIVSNFLQSFETAIEHNKEVEPLLG--RAQENLNPLVVLNLFKRIPAED 234
            +  K N K +DP  +    ++ T     KE+E          N+N  V           +
Sbjct: 1931 DSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFEMHHNINRFVF----------E 1980

Query: 235  VPLLLMNPEAG------KPSDLILTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIF 288
             P  L   + G      K   ++ T  L P +  R  V+S  +S T  + + + + E+  
Sbjct: 1981 TPFTLSGKKHGGVAEQCKRRTILTTSHLFPYVKKRIQVIS--QSSTELNPIEVAIDEM-- 2036

Query: 289  LNDVIKKHRISGAKTQMIMEDWDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGK 348
                    ++S       ME+ D ++LQ  L +   +S + +N  P  + R F++    K
Sbjct: 2037 ------SKKVSELNQLCTMEEVDMIRLQ--LKLQGSVS-VKVNAGPMAYARAFLEETNAK 2087

Query: 349  Q 349
            +
Sbjct: 2088 K 2088


>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog
           4 isoform JM-a/CVT-2 precursor [Homo sapiens]
          Length = 1292

 Score = 31.2 bits (69), Expect = 7.2
 Identities = 21/77 (27%), Positives = 40/77 (51%), Gaps = 4/77 (5%)

Query: 164 GTVKKCGLLKIIHEKYKTNKKVVD--PIVSNFLQSFETAIEHNKEVEPLLGRAQENLNPL 221
           GT  K   L  + ++Y+  +K  +   +V   L+   T+IEHN+++  L    +     L
Sbjct: 31  GTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEI--TSIEHNRDLSFLRSVREVTGYVL 88

Query: 222 VVLNLFKRIPAEDVPLL 238
           V LN F+ +P E++ ++
Sbjct: 89  VALNQFRYLPLENLRII 105


>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
           isoform JM-a/CVT-1 precursor [Homo sapiens]
          Length = 1308

 Score = 31.2 bits (69), Expect = 7.2
 Identities = 21/77 (27%), Positives = 40/77 (51%), Gaps = 4/77 (5%)

Query: 164 GTVKKCGLLKIIHEKYKTNKKVVD--PIVSNFLQSFETAIEHNKEVEPLLGRAQENLNPL 221
           GT  K   L  + ++Y+  +K  +   +V   L+   T+IEHN+++  L    +     L
Sbjct: 31  GTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEI--TSIEHNRDLSFLRSVREVTGYVL 88

Query: 222 VVLNLFKRIPAEDVPLL 238
           V LN F+ +P E++ ++
Sbjct: 89  VALNQFRYLPLENLRII 105


>gi|56549696 E1A binding protein p400 [Homo sapiens]
          Length = 3122

 Score = 31.2 bits (69), Expect = 7.2
 Identities = 27/93 (29%), Positives = 44/93 (47%), Gaps = 6/93 (6%)

Query: 973  IKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQVEKFLETCRDKYMRAQMEPGSA 1032
            ++  SE+ +    K  I  +  T+P +L    R T   VEK L    +  ++ ++   + 
Sbjct: 1241 LRAPSEESQDYYHKVVIRLHRVTQPFIL----RRTKRDVEKQLTKKYEHVLKCRLS--NR 1294

Query: 1033 VGALCAQSIGEPGTQMTLKTFHFAGVASMNITL 1065
              AL    I +PGTQ  LK+ HF  V S+ + L
Sbjct: 1295 QKALYEDVILQPGTQEALKSGHFVNVLSILVRL 1327


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,840,095
Number of Sequences: 37866
Number of extensions: 2345409
Number of successful extensions: 6520
Number of sequences better than 10.0: 8
Number of HSP's better than 10.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 6496
Number of HSP's gapped (non-prelim): 17
length of query: 1390
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1275
effective length of database: 13,892,928
effective search space: 17713483200
effective search space used: 17713483200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.