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Search of human proteins with 38327518
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38327518 BTB and kelch domain containing 3 [Homo sapiens]
(612 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38327518 BTB and kelch domain containing 3 [Homo sapiens] 1263 0.0
gi|38327516 BTB and kelch domain containing 3 [Homo sapiens] 1263 0.0
gi|40018614 DRE1 protein [Homo sapiens] 218 1e-56
gi|128485503 kelch-like 30 [Homo sapiens] 201 2e-51
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 196 5e-50
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 196 5e-50
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 193 3e-49
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 188 1e-47
gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Hom... 176 7e-44
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 174 2e-43
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 174 2e-43
gi|166235129 kelch-like 3 [Homo sapiens] 170 3e-42
gi|40255071 kelch-like 23 [Homo sapiens] 165 1e-40
gi|40807500 kelch-like 20 [Homo sapiens] 164 2e-40
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 163 4e-40
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 163 4e-40
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 162 8e-40
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 162 1e-39
gi|11056006 kelch-like 12 [Homo sapiens] 162 1e-39
gi|148664248 kelch domain containing 6 [Homo sapiens] 160 2e-39
gi|38194229 kelch-like 17 [Homo sapiens] 157 3e-38
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 154 2e-37
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 154 2e-37
gi|109150407 kelch-like 6 [Homo sapiens] 152 7e-37
gi|55925608 kelch-like 21 [Homo sapiens] 148 2e-35
gi|194097389 kelch-like 38 [Homo sapiens] 147 2e-35
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 146 6e-35
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 145 8e-35
gi|24308181 kelch-like 9 [Homo sapiens] 145 8e-35
gi|45643138 kelch-like 13 [Homo sapiens] 142 7e-34
>gi|38327518 BTB and kelch domain containing 3 [Homo sapiens]
Length = 612
Score = 1263 bits (3269), Expect = 0.0
Identities = 612/612 (100%), Positives = 612/612 (100%)
Query: 1 MELAMDNSYAFNQRSTCNGIPSEKKNNFLVSEDHGQKILSVLQNFREQNVFYDFKIIMKD 60
MELAMDNSYAFNQRSTCNGIPSEKKNNFLVSEDHGQKILSVLQNFREQNVFYDFKIIMKD
Sbjct: 1 MELAMDNSYAFNQRSTCNGIPSEKKNNFLVSEDHGQKILSVLQNFREQNVFYDFKIIMKD 60
Query: 61 EIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDD 120
EIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDD
Sbjct: 61 EIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDD 120
Query: 121 NVEMFFQLSSFLQVSFLSKACSDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHH 180
NVEMFFQLSSFLQVSFLSKACSDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHH
Sbjct: 121 NVEMFFQLSSFLQVSFLSKACSDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHH 180
Query: 181 FSLLFKSSDFLEMNFGVLQKCLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEK 240
FSLLFKSSDFLEMNFGVLQKCLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEK
Sbjct: 181 FSLLFKSSDFLEMNFGVLQKCLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEK 240
Query: 241 VRLHQLSEETLQDCLFNEESLLKSTNCFDIIMDAIKCVQGSGGLFPDARPSTTEKYIFIH 300
VRLHQLSEETLQDCLFNEESLLKSTNCFDIIMDAIKCVQGSGGLFPDARPSTTEKYIFIH
Sbjct: 241 VRLHQLSEETLQDCLFNEESLLKSTNCFDIIMDAIKCVQGSGGLFPDARPSTTEKYIFIH 300
Query: 301 KTEENGENQYTFCYNIKSDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRL 360
KTEENGENQYTFCYNIKSDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRL
Sbjct: 301 KTEENGENQYTFCYNIKSDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRL 360
Query: 361 HIAESYHDATDQTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKS 420
HIAESYHDATDQTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKS
Sbjct: 361 HIAESYHDATDQTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKS 420
Query: 421 LLDVESYNPLSKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYN 480
LLDVESYNPLSKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYN
Sbjct: 421 LLDVESYNPLSKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYN 480
Query: 481 ATTDQWSELVAEFGQFFHATLIKAVPVNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECA 540
ATTDQWSELVAEFGQFFHATLIKAVPVNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECA
Sbjct: 481 ATTDQWSELVAEFGQFFHATLIKAVPVNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECA 540
Query: 541 GFNAGAIGIEDKIYILGGDYAPDEITDEVQVYHSNRSEWEEVSPMPRALTEFYCQVIQFN 600
GFNAGAIGIEDKIYILGGDYAPDEITDEVQVYHSNRSEWEEVSPMPRALTEFYCQVIQFN
Sbjct: 541 GFNAGAIGIEDKIYILGGDYAPDEITDEVQVYHSNRSEWEEVSPMPRALTEFYCQVIQFN 600
Query: 601 KYRDPWFSNLCA 612
KYRDPWFSNLCA
Sbjct: 601 KYRDPWFSNLCA 612
>gi|38327516 BTB and kelch domain containing 3 [Homo sapiens]
Length = 612
Score = 1263 bits (3269), Expect = 0.0
Identities = 612/612 (100%), Positives = 612/612 (100%)
Query: 1 MELAMDNSYAFNQRSTCNGIPSEKKNNFLVSEDHGQKILSVLQNFREQNVFYDFKIIMKD 60
MELAMDNSYAFNQRSTCNGIPSEKKNNFLVSEDHGQKILSVLQNFREQNVFYDFKIIMKD
Sbjct: 1 MELAMDNSYAFNQRSTCNGIPSEKKNNFLVSEDHGQKILSVLQNFREQNVFYDFKIIMKD 60
Query: 61 EIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDD 120
EIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDD
Sbjct: 61 EIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDD 120
Query: 121 NVEMFFQLSSFLQVSFLSKACSDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHH 180
NVEMFFQLSSFLQVSFLSKACSDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHH
Sbjct: 121 NVEMFFQLSSFLQVSFLSKACSDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHH 180
Query: 181 FSLLFKSSDFLEMNFGVLQKCLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEK 240
FSLLFKSSDFLEMNFGVLQKCLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEK
Sbjct: 181 FSLLFKSSDFLEMNFGVLQKCLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEK 240
Query: 241 VRLHQLSEETLQDCLFNEESLLKSTNCFDIIMDAIKCVQGSGGLFPDARPSTTEKYIFIH 300
VRLHQLSEETLQDCLFNEESLLKSTNCFDIIMDAIKCVQGSGGLFPDARPSTTEKYIFIH
Sbjct: 241 VRLHQLSEETLQDCLFNEESLLKSTNCFDIIMDAIKCVQGSGGLFPDARPSTTEKYIFIH 300
Query: 301 KTEENGENQYTFCYNIKSDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRL 360
KTEENGENQYTFCYNIKSDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRL
Sbjct: 301 KTEENGENQYTFCYNIKSDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRL 360
Query: 361 HIAESYHDATDQTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKS 420
HIAESYHDATDQTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKS
Sbjct: 361 HIAESYHDATDQTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKS 420
Query: 421 LLDVESYNPLSKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYN 480
LLDVESYNPLSKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYN
Sbjct: 421 LLDVESYNPLSKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYN 480
Query: 481 ATTDQWSELVAEFGQFFHATLIKAVPVNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECA 540
ATTDQWSELVAEFGQFFHATLIKAVPVNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECA
Sbjct: 481 ATTDQWSELVAEFGQFFHATLIKAVPVNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECA 540
Query: 541 GFNAGAIGIEDKIYILGGDYAPDEITDEVQVYHSNRSEWEEVSPMPRALTEFYCQVIQFN 600
GFNAGAIGIEDKIYILGGDYAPDEITDEVQVYHSNRSEWEEVSPMPRALTEFYCQVIQFN
Sbjct: 541 GFNAGAIGIEDKIYILGGDYAPDEITDEVQVYHSNRSEWEEVSPMPRALTEFYCQVIQFN 600
Query: 601 KYRDPWFSNLCA 612
KYRDPWFSNLCA
Sbjct: 601 KYRDPWFSNLCA 612
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 218 bits (556), Expect = 1e-56
Identities = 162/593 (27%), Positives = 268/593 (45%), Gaps = 47/593 (7%)
Query: 27 NFLVSEDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMK 86
+F H + IL + FR+ +F D I ++ + PCHR VL+ACS +FRAMF + +
Sbjct: 41 DFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHR 100
Query: 87 ERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLI 146
E + V I + ++A++ FL Y YTGK KIT +NV+ F+ SS Q+S L AC+ FL
Sbjct: 101 ESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLE 160
Query: 147 KSINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDE 206
+ ++ NCL + +D++ +LF +F F + + +FLE++ L + SDE
Sbjct: 161 EQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDE 220
Query: 207 LNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTN 266
L + +EEMV + V+ W ++ R+ L L+ VRL L + ++ + S
Sbjct: 221 LVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPE 280
Query: 267 CFDIIMDAIKC-VQGSGGLFPDARPSTTEKY----IFIHKTEENG--ENQYTFCYNIKSD 319
C+ ++ +A + + G+ + P RP + Y + + E G YT CY+ +
Sbjct: 281 CYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTG 340
Query: 320 SWKILPQSHLIDLPGSSLSSYG-----EKIFLTGGCKGKCCRTVRLHIAESYHDATDQTW 374
WK L + LP + S Y I ++GG R++ + W
Sbjct: 341 EWKSLAK-----LPEFTKSEYAVCALRNDILVSGG---------RIN--------SRDVW 378
Query: 375 CYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEW 434
Y N + V+++ R H + L +++V+GG +R L VE Y+ S W
Sbjct: 379 IYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNR----LSSVECYDSFSNRW 434
Query: 435 ISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELVAEFG 494
V+PL + P ++C ++V+G + N D Y+ T+ W +
Sbjct: 435 TEVAPLKEAVSSPAVTSCVGKLFVIGGGPD----DNTCSDKVQSYDPETNSW---LLRAA 487
Query: 495 QFFHATLIKAVPVNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIY 554
I AV +N +Y+ T +Y + P W + N G KIY
Sbjct: 488 IPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIY 547
Query: 555 ILGGDYAPDEITDEVQVYHSNRSEWEEVSPMPRALTEFYCQVIQFNKYRDPWF 607
ILGG E TD + Y S V+ MPR ++ C + ++Y + F
Sbjct: 548 ILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGC--VTIHRYNEKCF 598
>gi|128485503 kelch-like 30 [Homo sapiens]
Length = 560
Score = 201 bits (510), Expect = 2e-51
Identities = 149/563 (26%), Positives = 253/563 (44%), Gaps = 43/563 (7%)
Query: 38 ILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITN 97
+L LQ R Q D +++ +PCHR +LA S +F AMF + E V + +
Sbjct: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRD 60
Query: 98 LSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSINLVNCLQL 157
+ V +D+ YTG+ IT NVE + ++ L + K C +L + ++ NCL +
Sbjct: 61 VEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGI 120
Query: 158 LSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVPEEEMVLK 217
+ G + A F++ +F + + +FL++ L CL D L V E+ L+
Sbjct: 121 CEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLE 180
Query: 218 VVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFDIIMDAIKC 277
++ W +H+ ++R +LP L+ V L + +Q L +E + +S C +
Sbjct: 181 ALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALS----- 235
Query: 278 VQGSGGLFPDARPSTTEKYIFI-----HKTEENGE------NQYTFCYNIKSDSWKILPQ 326
QG G P A E+ + + + EE GE + F YN K+ W LP
Sbjct: 236 -QGHDGA-PLALQQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAF-YNSKAKRWMALPD 292
Query: 327 SHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYCPVKNDFFLV 386
G SL++ I++TGG +G T +T Q WC+ + + V
Sbjct: 293 FPDYHKWGFSLAALNNNIYVTGGSRGTKTDTW----------STTQAWCFPLKEASWKPV 342
Query: 387 STMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPRGIYY 446
+ M PRT H S ++VIGG T +++VESY+P + W VSP + +
Sbjct: 343 APMLKPRTNHASAALNGEIYVIGGTT------LDVVEVESYDPYTDSWTPVSPALKYVSN 396
Query: 447 PEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELVAEFGQFFHATLIKAVP 506
A+ C+ +Y++GS +A +L C YN TD WS + + F + ++ +
Sbjct: 397 FSAAGCRGRLYLVGSSACKYNAL--ALQC---YNPVTDAWSVIASPFLPKYLSS-PRCAA 450
Query: 507 VNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGDY--APDE 564
++ LY+ +T KVY + P +W+ S N + + D +Y+ GG + +
Sbjct: 451 LHGELYLIGDNTKKVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGD 510
Query: 565 ITDEVQVYHSNRSEWEEVSPMPR 587
E++ Y + R W +PR
Sbjct: 511 YHVEMEAYDTVRDTWTRHGALPR 533
Score = 32.7 bits (73), Expect = 1.0
Identities = 32/140 (22%), Positives = 55/140 (39%), Gaps = 21/140 (15%)
Query: 313 CYNIKSDSWKILPQSHLID-LPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATD 371
CYN +D+W ++ L L ++ +++L G D T
Sbjct: 423 CYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIG-------------------DNTK 463
Query: 372 QTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLS 431
+ + Y P N + V + + V D L+V GG+ +G + ++E+Y+ +
Sbjct: 464 KVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHV-EMEAYDTVR 522
Query: 432 KEWISVSPLPRGIYYPEAST 451
W LPR Y AST
Sbjct: 523 DTWTRHGALPRLWLYHGAST 542
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 196 bits (498), Expect = 5e-50
Identities = 153/586 (26%), Positives = 260/586 (44%), Gaps = 61/586 (10%)
Query: 22 SEKKNNFLVSEDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMF 81
+EK V+ H +K V+ R QN+ D I+ +D I HR VLAACS +F AMF
Sbjct: 30 TEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMF 89
Query: 82 EVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKAC 141
M E V I + ++ +DY YT + ++T++NV++ + LQ+ + K C
Sbjct: 90 TGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTC 149
Query: 142 SDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKC 201
+FL ++ VNCL + + +D + T L + A + + HF+ + S +FL N G+ Q C
Sbjct: 150 CEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFL--NLGIEQVC 207
Query: 202 --LESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEE 259
+ SD+L + EE V + V++W H+ + RQ+++ L+E VRL L E L + E
Sbjct: 208 SLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEA 267
Query: 260 SLLKSTNCFDIIMDAIKCVQGSGGLFPDAR-------------PSTTEKYIFIHKTEENG 306
+ S+ C D +++A+K L P + P K + + +
Sbjct: 268 LVKNSSACKDYLIEAMKY-----HLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPK 322
Query: 307 ENQYTFCYNIKSDSWKILPQSHLIDLPG----SSLSSYGEKIFLTGGCKGKCCRTVRLHI 362
+ CY+ K + W + +LP + + +F GG G ++R+
Sbjct: 323 AIRSVECYDFKEERW-----HQVAELPSRRCRAGMVYMAGLVFAVGGFNG----SLRVRT 373
Query: 363 AESYHDATDQTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLL 422
+SY PVK+ + V+ M+ R+ + + L+ +GG GS + S
Sbjct: 374 VDSYD----------PVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGG-FDGSTGLSS-- 420
Query: 423 DVESYNPLSKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNAT 482
VE+YN S EW V+P+ ++Y +G + +++C YNAT
Sbjct: 421 -VEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVEC---YNAT 476
Query: 483 TDQWSELVAEFGQFFHATLIKAVPVNCTLYIC-----DLSTYKVYSFCPDTCVWKGEGSF 537
T++W+ +AE + +N LY L V + P T W+
Sbjct: 477 TNEWT-YIAEMSTRRSGAGVGV--LNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADM 533
Query: 538 ECAGFNAGAIGIEDKIYILGGDYAPDEITDEVQVYHSNRSEWEEVS 583
NAG + +Y++GGD + V+ Y+ +W VS
Sbjct: 534 NMCRRNAGVCAVNGLLYVVGGDDGSCNLA-SVEYYNPTTDKWTVVS 578
Score = 37.4 bits (85), Expect = 0.041
Identities = 46/207 (22%), Positives = 82/207 (39%), Gaps = 26/207 (12%)
Query: 389 MKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPRGIYYPE 448
MK+ RT + M L +L V+ G + K++ VE Y+ + W V+ LP
Sbjct: 296 MKSVRTRLRTPMNLPKLMVVVG----GQAPKAIRSVECYDFKEERWHQVAELP------- 344
Query: 449 ASTCQNVIYVLGSEVEITDAFNPSL--DCFFKYNATTDQWSELVAEFGQFFHATLIKAVP 506
+ C+ + + V FN SL Y+ DQW+ + + + A
Sbjct: 345 SRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVA---NMRDRRSTLGAAV 401
Query: 507 VNCTLYI-------CDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGG- 558
+N LY LS+ + Y+ + + + G +G +Y +GG
Sbjct: 402 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG--GLLYAVGGY 459
Query: 559 DYAPDEITDEVQVYHSNRSEWEEVSPM 585
D A + V+ Y++ +EW ++ M
Sbjct: 460 DGASRQCLSTVECYNATTNEWTYIAEM 486
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 196 bits (498), Expect = 5e-50
Identities = 153/586 (26%), Positives = 260/586 (44%), Gaps = 61/586 (10%)
Query: 22 SEKKNNFLVSEDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMF 81
+EK V+ H +K V+ R QN+ D I+ +D I HR VLAACS +F AMF
Sbjct: 26 TEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMF 85
Query: 82 EVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKAC 141
M E V I + ++ +DY YT + ++T++NV++ + LQ+ + K C
Sbjct: 86 TGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTC 145
Query: 142 SDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKC 201
+FL ++ VNCL + + +D + T L + A + + HF+ + S +FL N G+ Q C
Sbjct: 146 CEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFL--NLGIEQVC 203
Query: 202 --LESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEE 259
+ SD+L + EE V + V++W H+ + RQ+++ L+E VRL L E L + E
Sbjct: 204 SLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEA 263
Query: 260 SLLKSTNCFDIIMDAIKCVQGSGGLFPDAR-------------PSTTEKYIFIHKTEENG 306
+ S+ C D +++A+K L P + P K + + +
Sbjct: 264 LVKNSSACKDYLIEAMKY-----HLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPK 318
Query: 307 ENQYTFCYNIKSDSWKILPQSHLIDLPG----SSLSSYGEKIFLTGGCKGKCCRTVRLHI 362
+ CY+ K + W + +LP + + +F GG G ++R+
Sbjct: 319 AIRSVECYDFKEERW-----HQVAELPSRRCRAGMVYMAGLVFAVGGFNG----SLRVRT 369
Query: 363 AESYHDATDQTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLL 422
+SY PVK+ + V+ M+ R+ + + L+ +GG GS + S
Sbjct: 370 VDSYD----------PVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGG-FDGSTGLSS-- 416
Query: 423 DVESYNPLSKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNAT 482
VE+YN S EW V+P+ ++Y +G + +++C YNAT
Sbjct: 417 -VEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVEC---YNAT 472
Query: 483 TDQWSELVAEFGQFFHATLIKAVPVNCTLYIC-----DLSTYKVYSFCPDTCVWKGEGSF 537
T++W+ +AE + +N LY L V + P T W+
Sbjct: 473 TNEWT-YIAEMSTRRSGAGVGV--LNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADM 529
Query: 538 ECAGFNAGAIGIEDKIYILGGDYAPDEITDEVQVYHSNRSEWEEVS 583
NAG + +Y++GGD + V+ Y+ +W VS
Sbjct: 530 NMCRRNAGVCAVNGLLYVVGGDDGSCNLA-SVEYYNPTTDKWTVVS 574
Score = 37.4 bits (85), Expect = 0.041
Identities = 46/207 (22%), Positives = 82/207 (39%), Gaps = 26/207 (12%)
Query: 389 MKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPRGIYYPE 448
MK+ RT + M L +L V+ G + K++ VE Y+ + W V+ LP
Sbjct: 292 MKSVRTRLRTPMNLPKLMVVVG----GQAPKAIRSVECYDFKEERWHQVAELP------- 340
Query: 449 ASTCQNVIYVLGSEVEITDAFNPSL--DCFFKYNATTDQWSELVAEFGQFFHATLIKAVP 506
+ C+ + + V FN SL Y+ DQW+ + + + A
Sbjct: 341 SRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVA---NMRDRRSTLGAAV 397
Query: 507 VNCTLYI-------CDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGG- 558
+N LY LS+ + Y+ + + + G +G +Y +GG
Sbjct: 398 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG--GLLYAVGGY 455
Query: 559 DYAPDEITDEVQVYHSNRSEWEEVSPM 585
D A + V+ Y++ +EW ++ M
Sbjct: 456 DGASRQCLSTVECYNATTNEWTYIAEM 482
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 193 bits (491), Expect = 3e-49
Identities = 147/578 (25%), Positives = 262/578 (45%), Gaps = 52/578 (8%)
Query: 34 HGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSV 93
+ +L+ L R+Q +F D + + PCHR VLAACS +F AMF +KE D V
Sbjct: 28 YADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEV 87
Query: 94 TITN-LSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSINLV 152
N + + ++ LDYAY+ + I ++N E + L+ + AC++FL K+++
Sbjct: 88 NFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPT 147
Query: 153 NCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVPEE 212
NCL +L +SD++ T L++ + +F + K+ DFL++ ++ + L S+EL +E
Sbjct: 148 NCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDE 207
Query: 213 EMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFDIIM 272
+V + ++W ++L+ R YLP L++ VRL L L + + EE + K +I+
Sbjct: 208 RLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVE 267
Query: 273 DAIKC----VQGSGGLFP-DARPSTTEKYIFIHKTEENGENQYTFC---YNIKSDSWKIL 324
+AI+C +Q G + ARP T +F+ Q C Y + + +I+
Sbjct: 268 EAIRCKLKILQNDGVVTSLCARPRKTGHALFLL------GGQTFMCDKLYLVDQKAKEII 321
Query: 325 PQSHLIDLPGS----SLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYCPVK 380
P++ D+P S + G K+++TGG S + + W Y +
Sbjct: 322 PKA---DIPSPRKEFSACAIGCKVYITGG-------------RGSENGVSKDVWVYDTLH 365
Query: 381 NDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIK-----SLLDVESYNPLSKEWI 435
++ + M R H S L+V+GG T + + SL VE Y+P +W
Sbjct: 366 EEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWT 425
Query: 436 SVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELVAEFGQ 495
V+PL G+ + + ++ G D P + C Y+ ++W+ + A Q
Sbjct: 426 MVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKL-PKVQC---YDQCENRWT-VPATCPQ 480
Query: 496 FFHATLIKAVPVNCTLYI----CDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIED 551
+ T A + ++I + S Y F +T W G + A+ +
Sbjct: 481 PWRYT--AAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGN 538
Query: 552 KIYILGGDYAPDEITDEVQVYHSNRSEWEEVSPMPRAL 589
K+Y++GG Y + + Y W ++ +P +L
Sbjct: 539 KLYVVGG-YFGIQRCKTLDCYDPTLDVWNSITTVPYSL 575
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 188 bits (478), Expect = 1e-47
Identities = 150/578 (25%), Positives = 262/578 (45%), Gaps = 52/578 (8%)
Query: 34 HGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSV 93
H +L+ L R+ +F D + D PCHR VLAA S +F AMF ++E D +V
Sbjct: 28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTV 87
Query: 94 TIT-NLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSINLV 152
NL + ++ LD+AY+ + I ++N E + LQ + A ++FL K++
Sbjct: 88 NFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPS 147
Query: 153 NCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVPEE 212
NCL ++ +SD++ L++ + HF + +S DF ++ L + SDEL +E
Sbjct: 148 NCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDE 207
Query: 213 EMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFDIIM 272
+V + +L W KH+LE R+ +LP L+ VRL L + LQ+ + +E L+ I+
Sbjct: 208 RVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMD 267
Query: 273 DAIKC----VQGSGGL-FPDARPSTTEKYIFIHKTEENGENQYTFC---YNIKSDSWKIL 324
+A++C +Q G + P ARP + I Q C Y + + +I+
Sbjct: 268 EALRCKTRILQNDGVVTSPCARPRKAGHTLLIL------GGQTFMCDKIYQVDHKAKEII 321
Query: 325 PQSHLIDLPGS----SLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYCPVK 380
P++ DLP S S+ G K+++TGG S + + W Y V
Sbjct: 322 PKA---DLPSPRKEFSASAIGCKVYVTGG-------------RGSENGVSKDVWVYDTVH 365
Query: 381 NDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTR-----GSRDIKSLLDVESYNPLSKEWI 435
++ + M R H S + L+V+GG T + SL VE Y+P + +W+
Sbjct: 366 EEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWM 425
Query: 436 SVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELVAEFGQ 495
V+PL G+ + + ++V G D + + C Y+ + ++W+ + AE Q
Sbjct: 426 MVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVS-KVQC---YDPSENRWT-IKAECPQ 480
Query: 496 FFHATLIKAVPVNCTLYI----CDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIED 551
+ T A + ++I + + Y F +T W G + A+ +
Sbjct: 481 PWRYT--AAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGN 538
Query: 552 KIYILGGDYAPDEITDEVQVYHSNRSEWEEVSPMPRAL 589
K+Y++GG Y + + Y W ++ +P +L
Sbjct: 539 KLYVVGG-YFGTQRCKTLDCYDPTSDTWNCITTVPYSL 575
>gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Homo
sapiens]
Length = 623
Score = 176 bits (445), Expect = 7e-44
Identities = 129/474 (27%), Positives = 219/474 (46%), Gaps = 44/474 (9%)
Query: 30 VSEDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERD 89
++ ++ +L L+ F EQ +F D +I++ PCH+ VLA CS +FRAMF + E
Sbjct: 9 INTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESK 68
Query: 90 DGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSI 149
V + N+ + ++ + YAYTG + D VE ++ + FLQV + + C ++LIK I
Sbjct: 69 QTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKI 128
Query: 150 NLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNV 209
N NC++LLS +D + L A V+H F+ ++ F++++ +L L SD LNV
Sbjct: 129 NAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNV 188
Query: 210 PEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFD 269
+EE V + + W ++N ESR +YL ++ ++R+ LSE T + KS
Sbjct: 189 EKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSVVVQG 248
Query: 270 IIMDAIKCVQGSGGLFPDARPSTTEKYIFIHKTEENGENQY-TFCYNIKSDS-WKILPQS 327
+ K + G+ + E IFI + EN + Y + CY+ +++ +K+
Sbjct: 249 LYKSMPKFFKPRLGM------TKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPP 302
Query: 328 HLIDLPGSSLSSYGEKIFLTGG------CKGKCCRTVRLHIAES------YHDATDQTWC 375
+ G+ ++ + I++ GG K +T +L A + DA TW
Sbjct: 303 ADLHKVGTVVTPDND-IYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTW- 360
Query: 376 YCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWI 435
F + M R + V ++ IGG + G + VE Y+ EW
Sbjct: 361 --------FPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGE--LNRRTVERYDTEKDEWT 410
Query: 436 SVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSEL 489
VSPLP + A + IYV+ +L+ + Y +D W E+
Sbjct: 411 MVSPLPCAWQWSAAVVVHDCIYVM------------TLNLMYCYFPRSDSWVEM 452
Score = 31.6 bits (70), Expect = 2.2
Identities = 16/40 (40%), Positives = 22/40 (55%), Gaps = 1/40 (2%)
Query: 550 EDKIYILGGDYAPDEITDE-VQVYHSNRSEWEEVSPMPRA 588
E IY +GGD E+ V+ Y + + EW VSP+P A
Sbjct: 379 EGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCA 418
Score = 31.6 bits (70), Expect = 2.2
Identities = 33/152 (21%), Positives = 61/152 (40%), Gaps = 22/152 (14%)
Query: 374 WCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGG----KTRGSRDIKSLLD-----V 424
+CY P + + ++ +T R+ ++ D++F IGG G R +D V
Sbjct: 440 YCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTV 499
Query: 425 ESYNPLSKEWISVSPLPRGIYYP---EASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNA 481
E Y+ EW + +P Y A N + V E + + + ++Y+
Sbjct: 500 EIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHLNER---AKYVTYQYDL 556
Query: 482 TTDQWS-------ELVAEFGQFFHATLIKAVP 506
D+WS ++ + G+ F T+ K P
Sbjct: 557 ELDRWSLRQHISERVLWDLGRDFRCTVGKLYP 588
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 174 bits (441), Expect = 2e-43
Identities = 137/616 (22%), Positives = 261/616 (42%), Gaps = 102/616 (16%)
Query: 15 STCNGIPSEKKNNFLVSEDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACS 74
S+C+ + + F + +H ++ ++N+ D ++ D IP HR VL++ S
Sbjct: 137 SSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVS 196
Query: 75 DFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQV 134
D+F AMF +++E + + + ++ + + YAYTG+ ++ +DN+E + LQ+
Sbjct: 197 DYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQL 256
Query: 135 SFLSKACSDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMN 194
S + +AC FL+K ++ NCL + S +D+ G T L A ++ HF + ++ +F+ +
Sbjct: 257 SQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLP 316
Query: 195 FGVLQKCLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDC 254
+ K L SD++N+P EE +L +L+W +H+LE R+K L L+ +RL L+ + L D
Sbjct: 317 ASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD- 375
Query: 255 LFNEESLLKSTNCFDIIMDAIKCVQGSGGLFPDARP-----------STTEKYIFIHKTE 303
+ N C +IM+A+K L P+ RP ST + +
Sbjct: 376 MENNVLFRDDIECQKLIMEAMKY-----HLLPERRPMLQSPRTKPRKSTVGTLFAVGGMD 430
Query: 304 ENGENQYTFCYNIKSDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKG-KCCRTVRLHI 362
Y+++++ W + + L ++ +K+++ GG G K TV +
Sbjct: 431 STKGATSIEKYDLRTNMWTPVANMNGRRLQ-FGVAVLDDKLYVVGGRDGLKTLNTVECYN 489
Query: 363 AES-------------------------YHDATDQTWCYC-------PVKNDFFLVSTMK 390
++ Y W Y P + V+TM
Sbjct: 490 PKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMS 549
Query: 391 TPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPRGIYYPEAS 450
TPR+ + +L+ +GG+ GS +KS VE ++P + +W + + + +
Sbjct: 550 TPRSTVGVAVLSGKLYAVGGRD-GSSCLKS---VECFDPHTNKWTLCAQMSKRRGGVGVT 605
Query: 451 TCQNVIYVLGS-EVEITDAFNPSLDCFFKYNATTDQWSELVAEFGQFFHATLIKAVPVNC 509
T ++Y +G + ++ + DC +Y+ TD W+ +
Sbjct: 606 TWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAV-------------------- 645
Query: 510 TLYICDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGDYAPDEITDEV 569
S + G + DK+Y +GG Y + V
Sbjct: 646 -------------------------ASMSISRDAVGVCLLGDKLYAVGG-YDGQAYLNTV 679
Query: 570 QVYHSNRSEWEEVSPM 585
+ Y +EW +V+P+
Sbjct: 680 EAYDPQTNEWTQVAPL 695
Score = 31.2 bits (69), Expect = 2.9
Identities = 21/69 (30%), Positives = 36/69 (52%), Gaps = 6/69 (8%)
Query: 376 YCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLD-VESYNPLSKEW 434
Y P + + V++M R + D+L+ +GG D ++ L+ VE+Y+P + EW
Sbjct: 635 YDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGY-----DGQAYLNTVEAYDPQTNEW 689
Query: 435 ISVSPLPRG 443
V+PL G
Sbjct: 690 TQVAPLCLG 698
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 174 bits (441), Expect = 2e-43
Identities = 137/616 (22%), Positives = 261/616 (42%), Gaps = 102/616 (16%)
Query: 15 STCNGIPSEKKNNFLVSEDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACS 74
S+C+ + + F + +H ++ ++N+ D ++ D IP HR VL++ S
Sbjct: 183 SSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVS 242
Query: 75 DFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQV 134
D+F AMF +++E + + + ++ + + YAYTG+ ++ +DN+E + LQ+
Sbjct: 243 DYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQL 302
Query: 135 SFLSKACSDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMN 194
S + +AC FL+K ++ NCL + S +D+ G T L A ++ HF + ++ +F+ +
Sbjct: 303 SQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLP 362
Query: 195 FGVLQKCLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDC 254
+ K L SD++N+P EE +L +L+W +H+LE R+K L L+ +RL L+ + L D
Sbjct: 363 ASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD- 421
Query: 255 LFNEESLLKSTNCFDIIMDAIKCVQGSGGLFPDARP-----------STTEKYIFIHKTE 303
+ N C +IM+A+K L P+ RP ST + +
Sbjct: 422 MENNVLFRDDIECQKLIMEAMKY-----HLLPERRPMLQSPRTKPRKSTVGTLFAVGGMD 476
Query: 304 ENGENQYTFCYNIKSDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKG-KCCRTVRLHI 362
Y+++++ W + + L ++ +K+++ GG G K TV +
Sbjct: 477 STKGATSIEKYDLRTNMWTPVANMNGRRLQ-FGVAVLDDKLYVVGGRDGLKTLNTVECYN 535
Query: 363 AES-------------------------YHDATDQTWCYC-------PVKNDFFLVSTMK 390
++ Y W Y P + V+TM
Sbjct: 536 PKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMS 595
Query: 391 TPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPRGIYYPEAS 450
TPR+ + +L+ +GG+ GS +KS VE ++P + +W + + + +
Sbjct: 596 TPRSTVGVAVLSGKLYAVGGRD-GSSCLKS---VECFDPHTNKWTLCAQMSKRRGGVGVT 651
Query: 451 TCQNVIYVLGS-EVEITDAFNPSLDCFFKYNATTDQWSELVAEFGQFFHATLIKAVPVNC 509
T ++Y +G + ++ + DC +Y+ TD W+ +
Sbjct: 652 TWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAV-------------------- 691
Query: 510 TLYICDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGDYAPDEITDEV 569
S + G + DK+Y +GG Y + V
Sbjct: 692 -------------------------ASMSISRDAVGVCLLGDKLYAVGG-YDGQAYLNTV 725
Query: 570 QVYHSNRSEWEEVSPM 585
+ Y +EW +V+P+
Sbjct: 726 EAYDPQTNEWTQVAPL 741
Score = 31.2 bits (69), Expect = 2.9
Identities = 21/69 (30%), Positives = 36/69 (52%), Gaps = 6/69 (8%)
Query: 376 YCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLD-VESYNPLSKEW 434
Y P + + V++M R + D+L+ +GG D ++ L+ VE+Y+P + EW
Sbjct: 681 YDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGY-----DGQAYLNTVEAYDPQTNEW 735
Query: 435 ISVSPLPRG 443
V+PL G
Sbjct: 736 TQVAPLCLG 744
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 170 bits (431), Expect = 3e-42
Identities = 139/584 (23%), Positives = 250/584 (42%), Gaps = 59/584 (10%)
Query: 19 GIPSEKKNNFLVSEDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFR 78
G + + V+ H K V+ R + + D I+ +D I HR VLAACS +F
Sbjct: 17 GDDEKNQRTITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFC 76
Query: 79 AMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLS 138
AMF +M E + I ++ + + +DY YT + ++T++NV++ +S LQ+ +
Sbjct: 77 AMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVR 136
Query: 139 KACSDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVL 198
+ C DFL ++ NCL + + +D + T L A + + HF + +FL ++ +
Sbjct: 137 QNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQV 196
Query: 199 QKCLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNE 258
+ SD+L V EE V + V+SW + E+R +++ L+E VRL L + L + E
Sbjct: 197 CSLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTV-EE 255
Query: 259 ESLLKSTN-CFDIIMDAIKCVQGSGGLFP-DAR------------PSTTEKYIFIHKTEE 304
E+L+K+ N C D +++A+K L P D R P + K + + +
Sbjct: 256 EALIKNNNTCKDFLIEAMKY-----HLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQA 310
Query: 305 NGENQYTFCYNIKSDSWKILPQSHLIDLPG----SSLSSYGEKIFLTGGCKGKCCRTVRL 360
+ CY+ + D W + +LP + + ++ GG G ++R+
Sbjct: 311 PKAIRSVECYDFEEDRW-----DQIAELPSRRCRAGVVFMAGHVYAVGGFNG----SLRV 361
Query: 361 HIAESYHDATDQTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKS 420
+ Y DQ + +++M+ R+ + + D L+ +GG +
Sbjct: 362 RTVDVYDGVKDQ----------WTSIASMQERRSTLGAAVLNDLLYAVGGFDGST----G 407
Query: 421 LLDVESYNPLSKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYN 480
L VE+Y+ + EW V+P+ + +Y +G A L +YN
Sbjct: 408 LASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGG---YDGASRQCLSTVEQYN 464
Query: 481 ATTDQWSELVAEFGQFFHATLIKAVPVNCTLYIC-----DLSTYKVYSFCPDTCVWKGEG 535
T++W VA+ + ++ LY L V + P T WK
Sbjct: 465 PATNEWI-YVADMSTRRSGAGVGV--LSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVA 521
Query: 536 SFECAGFNAGAIGIEDKIYILGGDYAPDEITDEVQVYHSNRSEW 579
NAG + +Y++GGD + V+ Y+ +W
Sbjct: 522 DMNMCRRNAGVCAVNGLLYVVGGDDGSCNLA-SVEYYNPVTDKW 564
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 165 bits (417), Expect = 1e-40
Identities = 132/578 (22%), Positives = 251/578 (43%), Gaps = 60/578 (10%)
Query: 34 HGQKILSVLQNFREQNVFYDFKIIMKDEII-PCHRCVLAACSDFFRAMFEVNMKERDDGS 92
H L + F +F D + II CHR VLAACS++F+AMF +MKE+
Sbjct: 18 HPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKNK 77
Query: 93 VTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSINLV 152
+ ++ + ++ ++YAYT + +IT NV+ + + LQ + KAC FL++ +++
Sbjct: 78 IKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHLDID 137
Query: 153 NCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVPEE 212
NC+ + S ++ + L + + F +++ +FLE++ L L+V +E
Sbjct: 138 NCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNLSVWKE 197
Query: 213 EMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCF-DII 271
E +++ V+ WT H++E+R + L +L+ + + + L+ L + S L + N +I
Sbjct: 198 EAIIEPVIKWTAHDVENRIECLYNLLSYINI-DIDPVYLKTALGLQRSCLLTENKIRSLI 256
Query: 272 MDAIKCVQGSGGLFPDARPSTTEKYIFIHKTEENGENQYTFCYNIKSDSWKILPQSHLID 331
+A+ +HK E + Y I W L + H+ D
Sbjct: 257 YNALNP---------------------MHK--EISQRSTATMYIIGGYYWHPLSEVHIWD 293
Query: 332 ------LPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYH----DATDQTWCYCPVKN 381
+ G+ + Y + + G C +++ Y +A D W Y +
Sbjct: 294 PLTNVWIQGAEIPDYTRESY------GVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESD 347
Query: 382 DFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLP 441
++ M R H +V ++ +GG +G+ + E Y+PL ++WI ++ +
Sbjct: 348 EWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGA----PAEEAEFYDPLKEKWIPIANMI 403
Query: 442 RGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELVA----EFGQFF 497
+G+ A +VIYV+G + + D YN+ ++WS + + E+G
Sbjct: 404 KGVGNATACVLHDVIYVIGGHCGYRGSC--TYDKVQSYNSDINEWSLITSSPHPEYG--- 458
Query: 498 HATLIKAVPVNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILG 557
+ +VP LY+ T + P+ W+ GA+ + IY+ G
Sbjct: 459 ----LCSVPFENKLYLVGGQTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTG 514
Query: 558 G-DYAPDEITDEVQVYHSNRSEWEEVSPMPRALTEFYC 594
G Y+ ++ Y + ++WE V +P A+ C
Sbjct: 515 GYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHGC 552
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 164 bits (415), Expect = 2e-40
Identities = 128/525 (24%), Positives = 233/525 (44%), Gaps = 73/525 (13%)
Query: 19 GIPSEKKNNFLVSEDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFR 78
G+P + + +S+ H ++ L V+ R+ D +++ + I HR +L+ACS +FR
Sbjct: 36 GVPQPARMPY-ISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFR 94
Query: 79 AMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLS 138
AMF + E V I ++ +A++ +D+AYT + + + NV+ + LQ++ +
Sbjct: 95 AMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQ 154
Query: 139 KACSDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVL 198
+AC +FL + ++ NCL + + +D++ L A F QH+F + +S +F+ + L
Sbjct: 155 EACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQL 214
Query: 199 QKCLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNE 258
+ SDELNV EE V V++W K++++ R+ LP +++ VRL LS + L + ++
Sbjct: 215 IDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSD 274
Query: 259 ESLLKSTNCFDIIMDAIKCVQGSGGLFPDARPSTTEKYIFIHKTEENGENQYT---FC-- 313
+ C D++ +A + L P RP K GE + +C
Sbjct: 275 PLIKSDEECRDLVDEAKNYL-----LLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSG 329
Query: 314 --------YNIKSDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAES 365
Y+ +++ W+++ S G +S + ++ GG G + L+ E
Sbjct: 330 DAISSVERYDPQTNEWRMV-ASMSKRRCGVGVSVLDDLLYAVGGHDG----SSYLNSVER 384
Query: 366 YHDATDQTWC---------------------------------------YCPVKNDFFLV 386
Y T+Q W Y P +N + V
Sbjct: 385 YDPKTNQ-WSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRV 443
Query: 387 STMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPRGIYY 446
++M T R + L+ +G GS L VE YNP W +++P+ +
Sbjct: 444 ASMSTRRLGVAVAVLGGFLYAVG----GSDGTSPLNTVERYNPQENRWHTIAPMGTRRKH 499
Query: 447 PEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELVA 491
+ Q++IY +G + T+ L +YN T+QWS +VA
Sbjct: 500 LGCAVYQDMIYAVGGRDDTTE-----LSSAERYNPRTNQWSPVVA 539
Score = 39.3 bits (90), Expect = 0.011
Identities = 46/218 (21%), Positives = 81/218 (37%), Gaps = 22/218 (10%)
Query: 389 MKTPRTM-HTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPRGIYYP 447
M+ PRT + + LF +GG G ++ VE Y+P + EW V+ + +
Sbjct: 303 MQGPRTRPRKPIRCGEVLFAVGGWCSGD----AISSVERYDPQTNEWRMVASMSKRRCGV 358
Query: 448 EASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELVAEFGQFFHATLIKAVPV 507
S +++Y +G + L+ +Y+ T+QWS VA T + +
Sbjct: 359 GVSVLDDLLYAVGGHDG-----SSYLNSVERYDPKTNQWSSDVAPTSTC--RTSVGVAVL 411
Query: 508 NCTLY-------ICDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGDY 560
LY + L+ + Y P W S + +Y +GG
Sbjct: 412 GGFLYAVGGQDGVSCLNIVERYD--PKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSD 469
Query: 561 APDEITDEVQVYHSNRSEWEEVSPMPRALTEFYCQVIQ 598
+ + V+ Y+ + W ++PM C V Q
Sbjct: 470 GTSPL-NTVERYNPQENRWHTIAPMGTRRKHLGCAVYQ 506
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 163 bits (413), Expect = 4e-40
Identities = 144/596 (24%), Positives = 257/596 (43%), Gaps = 68/596 (11%)
Query: 34 HGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGS- 92
H +++L L R F D KI+++ H+ VLA+CS +F+ + + ++++ G
Sbjct: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
Query: 93 ----VTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKS 148
+ ++NL + ++ L++ YTG I N + + +S Q K C FL K
Sbjct: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
Query: 149 INLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELN 208
+ NCL +L+++++ + L+ A F F + + L ++ + +D LN
Sbjct: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
Query: 209 VPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCF 268
EE+V + V+ W K + +R +Y L+ VRL + L + + NEE + S C
Sbjct: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
Query: 269 DIIMDAIKCVQGSGGLFPDAR-----PST--------TEKYIFIHKTEENGENQYTF--- 312
D++ +A + + P AR P T E + + + G Q +
Sbjct: 551 DLVNEAKRY-----HMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAV 605
Query: 313 -CYNIKSDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATD 371
C+N +++ W L D S+ S G+ I+L+GG ES D
Sbjct: 606 TCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGG-------------MESGVTLAD 652
Query: 372 QTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGG-KTRGSRDIKSLLDVESYNPL 430
WCY + +++ LVS M PR H S++ +++ +GG G+ D VE Y+ +
Sbjct: 653 -VWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVD-----HVERYDTI 706
Query: 431 SKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELV 490
+ +W +V+PLP+ ++ A+ C IYV G E A Y T+ WS +
Sbjct: 707 TNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRA----AGVLQSYVPQTNTWSFIE 762
Query: 491 AEFGQFFHATLIKAVPVNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECAGFN------- 543
+ +A AV +N ++I ++ T ++ E AG N
Sbjct: 763 SPMIDNKYA---PAVTLNGFVFILG------GAYARATTIYDPEKGNIKAGPNMNHSRQF 813
Query: 544 AGAIGIEDKIYILGGDYAPD-EITDEVQVYHSNRSEWEEVSPMPRALTEFYCQVIQ 598
A+ ++ KIY GG + + ++ Y + W + MP + C VI+
Sbjct: 814 CSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVIK 869
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 163 bits (413), Expect = 4e-40
Identities = 144/596 (24%), Positives = 257/596 (43%), Gaps = 68/596 (11%)
Query: 34 HGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGS- 92
H +++L L R F D KI+++ H+ VLA+CS +F+ + + ++++ G
Sbjct: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
Query: 93 ----VTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKS 148
+ ++NL + ++ L++ YTG I N + + +S Q K C FL K
Sbjct: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
Query: 149 INLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELN 208
+ NCL +L+++++ + L+ A F F + + L ++ + +D LN
Sbjct: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
Query: 209 VPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCF 268
EE+V + V+ W K + +R +Y L+ VRL + L + + NEE + S C
Sbjct: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
Query: 269 DIIMDAIKCVQGSGGLFPDAR-----PST--------TEKYIFIHKTEENGENQYTF--- 312
D++ +A + + P AR P T E + + + G Q +
Sbjct: 551 DLVNEAKRY-----HMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAV 605
Query: 313 -CYNIKSDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATD 371
C+N +++ W L D S+ S G+ I+L+GG ES D
Sbjct: 606 TCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGG-------------MESGVTLAD 652
Query: 372 QTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGG-KTRGSRDIKSLLDVESYNPL 430
WCY + +++ LVS M PR H S++ +++ +GG G+ D VE Y+ +
Sbjct: 653 -VWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVD-----HVERYDTI 706
Query: 431 SKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELV 490
+ +W +V+PLP+ ++ A+ C IYV G E A Y T+ WS +
Sbjct: 707 TNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRA----AGVLQSYVPQTNTWSFIE 762
Query: 491 AEFGQFFHATLIKAVPVNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECAGFN------- 543
+ +A AV +N ++I ++ T ++ E AG N
Sbjct: 763 SPMIDNKYA---PAVTLNGFVFILG------GAYARATTIYDPEKGNIKAGPNMNHSRQF 813
Query: 544 AGAIGIEDKIYILGGDYAPD-EITDEVQVYHSNRSEWEEVSPMPRALTEFYCQVIQ 598
A+ ++ KIY GG + + ++ Y + W + MP + C VI+
Sbjct: 814 CSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVIK 869
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 162 bits (410), Expect = 8e-40
Identities = 143/615 (23%), Positives = 254/615 (41%), Gaps = 122/615 (19%)
Query: 33 DHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGS 92
+H ++ L ++N+ ++ D +I IP HR VL+A SD+F AMF ++ E
Sbjct: 163 NHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEE 222
Query: 93 VTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSINLV 152
V + + A+ + + YAYTG ++ +D +E + LQ++ + CS+FLIK ++
Sbjct: 223 VRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPS 282
Query: 153 NCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVPEE 212
NCL + S D+ G T L + A + HF + K+ +FL + + K L SD++NVP+E
Sbjct: 283 NCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDE 342
Query: 213 EMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFDIIM 272
E + ++ W H++++RQ L L+ +RL L + L D L C ++M
Sbjct: 343 ETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLM 401
Query: 273 DAIK------------------------CVQGSGGLFPDARPSTTEKY-----IFIHKTE 303
+A+K + GG+ +T EKY ++H
Sbjct: 402 EAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGT 461
Query: 304 ENGEN------------------------QYTFCYNIKSDSWKILPQSHLIDLPGSSLSS 339
NG C+N W ++P G +++
Sbjct: 462 MNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMS-THRHGLGVAT 520
Query: 340 YGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYCPVKNDFFLVSTMKTPRTMHTSV 399
++ GG H SY + ++ + P + V++M TPR+ V
Sbjct: 521 LEGPMYAVGG-----------HDGWSYLNTVER---WDPEGRQWNYVASMSTPRSTVGVV 566
Query: 400 MALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPRGIYYPEASTCQNVIYVL 459
++L+ IGG+ GS +KS+ E ++P + +W +P+ + +T +YV+
Sbjct: 567 ALNNKLYAIGGRD-GSSCLKSM---EYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVV 622
Query: 460 GS-EVEITDAFNPSLDCFFKYNATTDQWSELVAEFGQFFHATLIKAVPVNCTLYICDLST 518
G + ++ + DC +Y+ D WS + +VP +
Sbjct: 623 GGHDAPASNHCSRLSDCVERYDPKGDSWSTVAP-----------LSVPRDAV-------- 663
Query: 519 YKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGDYAPDEITDEVQVYHSNRSE 578
+ CP + DK+Y++GG Y + V+ Y + R+E
Sbjct: 664 ----AVCP----------------------LGDKLYVVGG-YDGHTYLNTVESYDAQRNE 696
Query: 579 WEEVSPMPRALTEFY 593
W+E M L FY
Sbjct: 697 WKE--SMQELLQNFY 709
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 162 bits (409), Expect = 1e-39
Identities = 140/607 (23%), Positives = 252/607 (41%), Gaps = 120/607 (19%)
Query: 33 DHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGS 92
+H ++ L ++N+ ++ D +I IP HR VL+A SD+F AMF ++ E
Sbjct: 163 NHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEE 222
Query: 93 VTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSINLV 152
V + + A+ + + YAYTG ++ +D +E + LQ++ + CS+FLIK ++
Sbjct: 223 VRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPS 282
Query: 153 NCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVPEE 212
NCL + S D+ G T L + A + HF + K+ +FL + + K L SD++NVP+E
Sbjct: 283 NCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDE 342
Query: 213 EMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFDIIM 272
E + ++ W H++++RQ L L+ +RL L + L D L C ++M
Sbjct: 343 ETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLM 401
Query: 273 DAIK------------------------CVQGSGGLFPDARPSTTEKY-----IFIHKTE 303
+A+K + GG+ +T EKY ++H
Sbjct: 402 EAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGT 461
Query: 304 ENGEN------------------------QYTFCYNIKSDSWKILPQSHLIDLPGSSLSS 339
NG C+N W ++P G +++
Sbjct: 462 MNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMS-THRHGLGVAT 520
Query: 340 YGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYCPVKNDFFLVSTMKTPRTMHTSV 399
++ GG H SY + ++ + P + V++M TPR+ V
Sbjct: 521 LEGPMYAVGG-----------HDGWSYLNTVER---WDPEGRQWNYVASMSTPRSTVGVV 566
Query: 400 MALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPRGIYYPEASTCQNVIYVL 459
++L+ IGG+ GS +KS+ E ++P + +W +P+ + +T +YV+
Sbjct: 567 ALNNKLYAIGGRD-GSSCLKSM---EYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVV 622
Query: 460 GS-EVEITDAFNPSLDCFFKYNATTDQWSELVAEFGQFFHATLIKAVPVNCTLYICDLST 518
G + ++ + DC +Y+ D WS + +VP +
Sbjct: 623 GGHDAPASNHCSRLSDCVERYDPKGDSWSTVAP-----------LSVPRDAV-------- 663
Query: 519 YKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGDYAPDEITDEVQVYHSNRSE 578
+ CP + DK+Y++GG Y + V+ Y + R+E
Sbjct: 664 ----AVCP----------------------LGDKLYVVGG-YDGHTYLNTVESYDAQRNE 696
Query: 579 WEEVSPM 585
W+E P+
Sbjct: 697 WKEEVPV 703
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 162 bits (409), Expect = 1e-39
Identities = 140/573 (24%), Positives = 249/573 (43%), Gaps = 45/573 (7%)
Query: 29 LVSEDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKER 88
+++ H + IL+ + + R+ N D + ++ + P HR VLAACSD+F AMF + E+
Sbjct: 10 IMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEK 69
Query: 89 DDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKS 148
V I L++ ++ LD+ YT +T +NV+ + LQ+ + +AC +FL
Sbjct: 70 GKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQ 129
Query: 149 INLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELN 208
++ NCL + ++++ L A F Q HF + + +F+ ++ G ++K ++ DE+
Sbjct: 130 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQ 189
Query: 209 VPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCF 268
V EE V + V++W KH + R++ LP+L++ VR+ L+ + D + E + S C
Sbjct: 190 VDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCR 249
Query: 269 DIIMDAIK------CVQGSGGLFPDARPSTTEKYIFIHK-TEENGENQYTFCYNIKSDSW 321
D++ +A K G AR E + + + Y+ K+ W
Sbjct: 250 DLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEW 309
Query: 322 KILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAE--SYHDATDQTWCYCPV 379
LP +S+S + ++I++ GG G+ RL E Y D W
Sbjct: 310 SFLPSITRKRRYVASVSLH-DRIYVIGGYDGRS----RLSSVECLDYTADEDGVW----- 359
Query: 380 KNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSP 439
+ V+ M R + + D ++V GG GSR S+ E Y+P +W +
Sbjct: 360 ----YSVAPMNVRRGLAGATTLGDMIYVSGG-FDGSRRHTSM---ERYDPNIDQWSMLGD 411
Query: 440 LPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELVAEFGQFFHA 499
+ VIY LG D N L+ KY+ T W+ + + A
Sbjct: 412 MQTAREGAGLVVASGVIYCLGG----YDGLN-ILNSVEKYDPHTGHWTNVTPMATKRSGA 466
Query: 500 TLIKAVPVNCTLYI-------CDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDK 552
+ +N +Y+ LS+ + Y+ D+ W S GA + +
Sbjct: 467 GV---ALLNDHIYVVGGFDGTAHLSSVEAYNIRTDS--WTTVTSMTTPRCYVGATVLRGR 521
Query: 553 IYILGGDYAPDEITDEVQVYHSNRSEWEEVSPM 585
+Y + G Y + + ++ Y WE V+ M
Sbjct: 522 LYAIAG-YDGNSLLSSIECYDPIIDSWEVVTSM 553
Score = 31.2 bits (69), Expect = 2.9
Identities = 29/119 (24%), Positives = 53/119 (44%), Gaps = 10/119 (8%)
Query: 376 YCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWI 435
Y P + V+ M T R+ + D ++V+GG G+ + S VE+YN + W
Sbjct: 446 YDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFD-GTAHLSS---VEAYNIRTDSWT 501
Query: 436 SVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELVAEFG 494
+V+ + Y A+ + +Y + ++ S++C Y+ D W E+V G
Sbjct: 502 TVTSMTTPRCYVGATVLRGRLYAIAG--YDGNSLLSSIEC---YDPIIDSW-EVVTSMG 554
>gi|148664248 kelch domain containing 6 [Homo sapiens]
Length = 623
Score = 160 bits (406), Expect = 2e-39
Identities = 145/603 (24%), Positives = 259/603 (42%), Gaps = 81/603 (13%)
Query: 34 HGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSV 93
H +L+ +QN +E D + + E PCHR VLAA S +F+AMF + E + V
Sbjct: 13 HSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMFTCGLLECNQREV 72
Query: 94 TITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSINLVN 153
+ ++++++V L+Y Y +I + NV+ + F+Q+ + C +++ ++ N
Sbjct: 73 ILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDASN 132
Query: 154 CLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVPEEE 213
CL + + G+ L D + ++ HF+ + + LE+ ++SD+LN+ EE
Sbjct: 133 CLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISREE 192
Query: 214 MVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFDIIMD 273
+L +VL W HN E R +L L+++VRL ++ L+ L LL +C DII +
Sbjct: 193 SILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLRQALRRNTMLLCDADCVDIIQN 252
Query: 274 AIKCVQGSGGLFPDAR--PSTTEKYIFIHKTEENGENQY------TFCYNIKSDSWKILP 325
A K ++ + R TT + I +++ +FCY+ +
Sbjct: 253 AFKAIKTPQQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYD------PVSR 306
Query: 326 QSHLIDLP--GSSLSSY-------GEKIFLTG-GCKGKCCRTVRLHI-AESYHDATDQTW 374
+++ I P G L + I + G K R ++ YHD +Q W
Sbjct: 307 KTYFISSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFW 366
Query: 375 ---CYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLS 431
C + + L S +H L+VIGG+ + V+ Y+
Sbjct: 367 EKLCTAEFRELYALGS-------IHND------LYVIGGQMKIKNQYLITNCVDKYSVER 413
Query: 432 KEWISVSPLPRGIYYPEASTCQNVIYVLGS---EVEITDAFNPSL-DCFFKYNATTDQWS 487
W VSPLP + T N +YV+G ++++ D L + +Y+ + DQWS
Sbjct: 414 DNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWS 473
Query: 488 -ELVAEFGQFFHATLIKAVPVNCTLYICD---------------LSTYKVYSFCPDTCVW 531
++ ++ +T + VN +Y+ L ++Y+ PD W
Sbjct: 474 VRAPMKYSKYRFSTAV----VNSEIYVLGGIGCVGQDKGQVRKCLDVVEIYN--PDGDFW 527
Query: 532 KGEG--------SFECAGFNAGAIGIEDKIYILGGDYAPDE---ITDEVQVYHSNRSEWE 580
+ EG S NAGA ++ K+Y+ GG + D I+ E+ ++W
Sbjct: 528 R-EGPPMPSPLLSLRTNSTNAGA--VDGKLYVCGGFHGADRHEVISKEILELDPWENQWN 584
Query: 581 EVS 583
V+
Sbjct: 585 VVA 587
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 157 bits (397), Expect = 3e-38
Identities = 134/575 (23%), Positives = 248/575 (43%), Gaps = 55/575 (9%)
Query: 31 SEDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDD 90
S+ H + R++ + D + + + I H+ VLA+CS +F AMF M E
Sbjct: 71 SKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQ 130
Query: 91 GSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSIN 150
VT+ ++ +A+ + +AYT + + + NV+ +S LQ++ + AC FL+ ++
Sbjct: 131 THVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLD 190
Query: 151 LVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVP 210
NCL + +D++ + L A +V HF + K+ +F+ + + + + SD LNVP
Sbjct: 191 PSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVP 250
Query: 211 EEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFDI 270
EE V + VLSW KH++++R++++P L++ VRL LS + L + E + +C D+
Sbjct: 251 SEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDL 310
Query: 271 IMDAIKCVQGSGGLFPDARPSTTEKYIFIHKTEENGENQYTF-------------CYNIK 317
+++A+K L P+ R + E G + Y+ +
Sbjct: 311 LIEALKF-----HLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTR 365
Query: 318 SDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYC 377
+D W ++ S +++ G +++ GG G T L ESY
Sbjct: 366 TDRWHVV-ASMSTRRARVGVAAVGNRLYAVGGYDG----TSDLATVESYD---------- 410
Query: 378 PVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISV 437
PV N + +M T R+ V AL L G G+ + S E Y+PL+ W SV
Sbjct: 411 PVTNTWQPEVSMGTRRSC-LGVAALHGLLYSAGGYDGASCLNS---AERYDPLTGTWTSV 466
Query: 438 SPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELVAEFGQFF 497
+ + Y +T +Y +G + L KY + WS + + +
Sbjct: 467 AAMSTRRRYVRVATLDGNLYAVGGYDS-----SSHLATVEKYEPQVNVWSPVASMLSRRS 521
Query: 498 HATLIKAVPVNCTLYICD-------LSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIE 550
A + + LY+ L++ + YS P W+ + ++
Sbjct: 522 SAGV---AVLEGALYVAGGNDGTSCLNSVERYS--PKAGAWESVAPMNIRRSTHDLVAMD 576
Query: 551 DKIYILGGDYAPDEITDEVQVYHSNRSEWEEVSPM 585
+Y +GG+ + + ++ Y+ ++W S M
Sbjct: 577 GWLYAVGGNDGSSSL-NSIEKYNPRTNKWVAASCM 610
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 154 bits (389), Expect = 2e-37
Identities = 128/523 (24%), Positives = 227/523 (43%), Gaps = 61/523 (11%)
Query: 85 MKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDF 144
M E V I + ++ +DY YT + ++T++NV++ + LQ+ + K C +F
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 145 LIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKC--L 202
L ++ VNCL + + +D + T L + A + + HF+ + S +FL N G+ Q C +
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFL--NLGIEQVCSLI 118
Query: 203 ESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLL 262
SD+L + EE V + V++W H+ + RQ+++ L+E VRL L E L + E +
Sbjct: 119 SSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVK 178
Query: 263 KSTNCFDIIMDAIKCVQGSGGLFPDAR-------------PSTTEKYIFIHKTEENGENQ 309
S+ C D +++A+K L P + P K + + + +
Sbjct: 179 NSSACKDYLIEAMKY-----HLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIR 233
Query: 310 YTFCYNIKSDSWKILPQSHLIDLPG----SSLSSYGEKIFLTGGCKGKCCRTVRLHIAES 365
CY+ K + W + +LP + + +F GG G ++R+ +S
Sbjct: 234 SVECYDFKEERW-----HQVAELPSRRCRAGMVYMAGLVFAVGGFNG----SLRVRTVDS 284
Query: 366 YHDATDQTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVE 425
Y PVK+ + V+ M+ R+ + + L+ +GG GS + S VE
Sbjct: 285 YD----------PVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGG-FDGSTGLSS---VE 330
Query: 426 SYNPLSKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQ 485
+YN S EW V+P+ ++Y +G + +++C YNATT++
Sbjct: 331 AYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVEC---YNATTNE 387
Query: 486 WSELVAEFGQFFHATLIKAVPVNCTLYIC-----DLSTYKVYSFCPDTCVWKGEGSFECA 540
W+ +AE + +N LY L V + P T W+
Sbjct: 388 WT-YIAEMSTRRSGAGVGV--LNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMC 444
Query: 541 GFNAGAIGIEDKIYILGGDYAPDEITDEVQVYHSNRSEWEEVS 583
NAG + +Y++GGD + V+ Y+ +W VS
Sbjct: 445 RRNAGVCAVNGLLYVVGGDDGSCNLA-SVEYYNPTTDKWTVVS 486
Score = 37.4 bits (85), Expect = 0.041
Identities = 46/207 (22%), Positives = 82/207 (39%), Gaps = 26/207 (12%)
Query: 389 MKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPRGIYYPE 448
MK+ RT + M L +L V+ G + K++ VE Y+ + W V+ LP
Sbjct: 204 MKSVRTRLRTPMNLPKLMVVVG----GQAPKAIRSVECYDFKEERWHQVAELP------- 252
Query: 449 ASTCQNVIYVLGSEVEITDAFNPSL--DCFFKYNATTDQWSELVAEFGQFFHATLIKAVP 506
+ C+ + + V FN SL Y+ DQW+ + + + A
Sbjct: 253 SRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVA---NMRDRRSTLGAAV 309
Query: 507 VNCTLYI-------CDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGG- 558
+N LY LS+ + Y+ + + + G +G +Y +GG
Sbjct: 310 LNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG--GLLYAVGGY 367
Query: 559 DYAPDEITDEVQVYHSNRSEWEEVSPM 585
D A + V+ Y++ +EW ++ M
Sbjct: 368 DGASRQCLSTVECYNATTNEWTYIAEM 394
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 154 bits (389), Expect = 2e-37
Identities = 127/564 (22%), Positives = 238/564 (42%), Gaps = 102/564 (18%)
Query: 67 RCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFF 126
R VL++ SD+F AMF +++E + + + ++ + + YAYTG+ ++ +DN+E
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 127 QLSSFLQVSFLSKACSDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFK 186
+ LQ+S + +AC FL+K ++ NCL + S +D+ G T L A ++ HF + +
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 187 SSDFLEMNFGVLQKCLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQL 246
+ +F+ + + K L SD++N+P EE +L +L+W +H+LE R+K L L+ +RL L
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
Query: 247 SEETLQDCLFNEESLLKSTNCFDIIMDAIKCVQGSGGLFPDARP-----------STTEK 295
+ + L D + N C +IM+A+K L P+ RP ST
Sbjct: 354 APQFLAD-MENNVLFRDDIECQKLIMEAMKY-----HLLPERRPMLQSPRTKPRKSTVGT 407
Query: 296 YIFIHKTEENGENQYTFCYNIKSDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKG-KC 354
+ + Y+++++ W + + L ++ +K+++ GG G K
Sbjct: 408 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQ-FGVAVLDDKLYVVGGRDGLKT 466
Query: 355 CRTVRLHIAES-------------------------YHDATDQTWCYC-------PVKND 382
TV + ++ Y W Y P
Sbjct: 467 LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQ 526
Query: 383 FFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPR 442
+ V+TM TPR+ + +L+ +GG+ GS +KS VE ++P + +W + + +
Sbjct: 527 WNFVATMSTPRSTVGVAVLSGKLYAVGGRD-GSSCLKS---VECFDPHTNKWTLCAQMSK 582
Query: 443 GIYYPEASTCQNVIYVLGS-EVEITDAFNPSLDCFFKYNATTDQWSELVAEFGQFFHATL 501
+T ++Y +G + ++ + DC +Y+ TD W+ +
Sbjct: 583 RRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAV------------ 630
Query: 502 IKAVPVNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGDYA 561
S + G + DK+Y +GG Y
Sbjct: 631 ---------------------------------ASMSISRDAVGVCLLGDKLYAVGG-YD 656
Query: 562 PDEITDEVQVYHSNRSEWEEVSPM 585
+ V+ Y +EW +V+P+
Sbjct: 657 GQAYLNTVEAYDPQTNEWTQVAPL 680
Score = 31.2 bits (69), Expect = 2.9
Identities = 21/69 (30%), Positives = 36/69 (52%), Gaps = 6/69 (8%)
Query: 376 YCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLD-VESYNPLSKEW 434
Y P + + V++M R + D+L+ +GG D ++ L+ VE+Y+P + EW
Sbjct: 620 YDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGY-----DGQAYLNTVEAYDPQTNEW 674
Query: 435 ISVSPLPRG 443
V+PL G
Sbjct: 675 TQVAPLCLG 683
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 152 bits (385), Expect = 7e-37
Identities = 129/564 (22%), Positives = 249/564 (44%), Gaps = 43/564 (7%)
Query: 42 LQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSK 101
L+ R +N D + + + CHR VLAA S++FRAMF ++KE+ + + I + ++
Sbjct: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAE 121
Query: 102 AVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSINLVNCLQLLSIS 161
+ LDY YT K IT NV+ + ++ Q + AC+ FL +++N NC+ +L ++
Sbjct: 122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLA 181
Query: 162 DSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVPEEEMVLKVVLS 221
D++ SL ++ +F + S +FL++ L L+SD+L V EE V + V+S
Sbjct: 182 DTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMS 241
Query: 222 WTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFDIIMDA-IKCVQG 280
W +H R LP+++E VRL L + + + + + F ++ +A + + G
Sbjct: 242 WVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSG 301
Query: 281 SGGLFPDARPS----TTEKYIFIH--KTEENGENQYTFCYNIKSDSWKI--LP-QSHLID 331
+ + +P +E ++ I +E + T ++ ++ LP H ++
Sbjct: 302 NEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELE 361
Query: 332 LPGSSLSSYG-----EKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYCPVKNDFFLV 386
+ +++++GG E+ HD W Y N + +
Sbjct: 362 SENKKWVEFACVTLKNEVYISGG-------------KETQHD----VWKYNSSINKWIQI 404
Query: 387 STMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPRGIYY 446
+ R H V+ +++VIG G ++ + +VE+Y+P W +PL +
Sbjct: 405 EYLNIGRWRHKMVVLGGKVYVIG----GFDGLQRINNVETYDPFHNCWSEAAPLLVHVSS 460
Query: 447 PEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELVAEFGQFFHATLIKAVP 506
A++ + +YV+G A + + C Y+ +T++WS A A I AV
Sbjct: 461 FAATSHKKKLYVIGGGPNGKLATDKT-QC---YDPSTNKWSLKAA---MPVEAKCINAVS 513
Query: 507 VNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGDYAPDEIT 566
+Y+ + +Y++ P W + G +++YI GG +E+
Sbjct: 514 FRDRIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVI 573
Query: 567 DEVQVYHSNRSEWEEVSPMPRALT 590
V + + E +PR ++
Sbjct: 574 ATVLCWDPEAQKLTEECVLPRGVS 597
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 148 bits (373), Expect = 2e-35
Identities = 138/589 (23%), Positives = 241/589 (40%), Gaps = 51/589 (8%)
Query: 34 HGQKILSVLQNFREQNVFYDFKI-IMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGS 92
H +L L R + F D + P HR VLAA S +FRAMF ++E
Sbjct: 17 HALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAER 76
Query: 93 VTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSINLV 152
V + + ++ LD++YTG+ ++ DN E + + LQ + +AC FL + ++L
Sbjct: 77 VRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLA 136
Query: 153 NCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVPEE 212
NCL + ++++ + L A F+ H L + + L + L D L VP+E
Sbjct: 137 NCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDGLCVPKE 195
Query: 213 EMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFDIIM 272
E ++ L W + + R + P L+E VRL + L + E + + C ++
Sbjct: 196 EAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLR 255
Query: 273 D-----AIKCVQGSGGLFPDARP----STTEKYIFIHKTEENGENQYTF-CYNIKSDSWK 322
+ A + + G P RP E + + +++ + T CYN ++ W+
Sbjct: 256 EARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWR 315
Query: 323 ILPQ--SHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYCPVK 380
L + HL G S+ + G I++TGG G RL+ D W Y
Sbjct: 316 YLAEFPDHLGG--GYSIVALGNDIYVTGGSDGS-----RLY---------DCVWRYNSSV 359
Query: 381 NDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPL 440
N++ V+ M R H+S + L+V+ + E Y+ + W ++ P+
Sbjct: 360 NEWAEVAPMLKAREYHSSSVLDGLLYVVAADS-----------TERYDHTTDSWEALQPM 408
Query: 441 PRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELVAEFGQFFHAT 500
+ + C+ +Y +GS + + C Y+ TD WS + + GQ +
Sbjct: 409 TYPMDNCSTTACRGRLYAIGS---LAGKETMVMQC---YDPDTDLWS--LVDCGQLPPWS 460
Query: 501 LI-KAVPVNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGD 559
K +N +Y + +V + P W S + K+Y+ GG
Sbjct: 461 FAPKTATLNGLMYFVRDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGY 520
Query: 560 YAPDEITDEVQVYHSNRSEWEEVSPMPRALTEFYCQVIQFNKYRDPWFS 608
E++D V+ Y W V +P T ++ V F ++ FS
Sbjct: 521 DNTFELSDVVEAYDPETRAWSVVGRLPEP-TFWHGSVSIFRQFMPQTFS 568
>gi|194097389 kelch-like 38 [Homo sapiens]
Length = 581
Score = 147 bits (372), Expect = 2e-35
Identities = 136/593 (22%), Positives = 247/593 (41%), Gaps = 40/593 (6%)
Query: 23 EKKNNFLVSEDH--GQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAM 80
E+ + L+ +DH +L L + R+ + D I IPCHR VLA+ S +FRAM
Sbjct: 3 EESLDGLLFKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAM 62
Query: 81 FEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKA 140
F + +E+ + V + + + + Y YTG+ I DNV + +S LQ L +A
Sbjct: 63 FCSSFREKSEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEA 122
Query: 141 CSDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQK 200
CS +L + NCL ++ +S+ +L A F + S+D E+ L+
Sbjct: 123 CSSYLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRD 182
Query: 201 CLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEES 260
L D L EEE V + ++ W KH+L++R++Y+ L ++VRL + + N ++
Sbjct: 183 YLGDDGL-CGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIAN-DA 240
Query: 261 LLKSTNCFDIIMDAIKCVQGS--GGLFPDAR-----PSTTEKYIFIHKTEENGENQYT-- 311
LL+S+ II++ K S G PD + P F+ ++Q T
Sbjct: 241 LLQSSPACQIILETAKRQMFSLCGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTTR 300
Query: 312 --FCYNIKSDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDA 369
Y+ ++ W+ L + S+++ + I++ GG R++ H
Sbjct: 301 DVLLYSKQTGQWQSLAKLPTRLYKASAITLH-RSIYVLGGMAVSSGRSLVSH-------- 351
Query: 370 TDQTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNP 429
+ + N + L M R H S + +F IGG G + S+ E Y+
Sbjct: 352 --NVYIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSM---ERYDS 406
Query: 430 LSKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSEL 489
+ W S++ +P G+ +P + +Y+ G E D + Y+ + + W ++
Sbjct: 407 ICNVWESMASMPVGVLHPAVAVKDQRLYLFGGE----DIMQNPVRLIQVYHISRNSWFKM 462
Query: 490 VAEFGQFFHATLIKAVPVNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGI 549
+ AV + + I T ++ ++ P + + + + GA +
Sbjct: 463 ET---RMIKNVCAPAVVLGERIVIVGGYTRRILAYDPQSNKFVKCADMKDRRMHHGATVM 519
Query: 550 EDKIYILGGDYAPDEITDE----VQVYHSNRSEWEEVSPMPRALTEFYCQVIQ 598
+K+Y+ GG + E Y W +P L + C +Q
Sbjct: 520 GNKLYVTGGRRLTTDCNIEDSASFDCYDPETDTWTSQGQLPHKLFDHACLTLQ 572
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 146 bits (368), Expect = 6e-35
Identities = 131/584 (22%), Positives = 239/584 (40%), Gaps = 97/584 (16%)
Query: 22 SEKKNNFLVSEDHGQKILS----VLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFF 77
S+KK ++ K+L+ V+ N R+Q D +++++ IP HR VLAA S FF
Sbjct: 10 SKKKTEKKLAAREEAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFF 69
Query: 78 RAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFL 137
MF NM E V + + ++ +++AYT + + +NV+ ++ Q+ +
Sbjct: 70 NLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPV 129
Query: 138 SKACSDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGV 197
K C DFL + ++ NCL + +++ L A F+ HF+ ++K+ +FL+++
Sbjct: 130 KKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKR 189
Query: 198 LQKCLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFN 257
+ L D L V E+ V + W K++ +RQ ++ ++ KVR +S+ L +
Sbjct: 190 VTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQA 249
Query: 258 EESLLKSTNCFDIIMDAIKCVQGSGGLFPDARPSTTEKYIFIHKTEENGENQYTFCYNIK 317
E + + C +++ ++ Y++
Sbjct: 250 EPLIQDNPECLKMVISGMR-------------------------------------YHLL 272
Query: 318 SDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTW--C 375
S + L+D + +I L GG + + CR Y + D +W
Sbjct: 273 SPE----DREELVDGTRPRRKKHDYRIALFGGSQPQSCR---------YFNPKDYSWTDI 319
Query: 376 YCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWI 435
CP + R V + ++++GG + + ++ YN + W
Sbjct: 320 RCPFEK-----------RRDAACVFWDNVVYILGGS-----QLFPIKRMDCYNVVKDSWY 363
Query: 436 SV--SPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELVAEF 493
S P PR A + IY G ++ N +L F Y+ T+ W +
Sbjct: 364 SKLGPPTPRDSL--AACAAEGKIYTSGG----SEVGNSALYLFECYDTRTESWHTKPSML 417
Query: 494 GQFFHATLIKAVPVNCTLYICD-----------LSTYKVYSFCPDTCVWKGEGSFECAGF 542
Q +++A N +Y+C L++ +VY P T W A
Sbjct: 418 TQRCSHGMVEA---NGLIYVCGGSLGNNVSGRVLNSCEVYD--PATETWTELCPMIEARK 472
Query: 543 NAGAIGIEDKIYILGGDYAPDEITDEVQVYHSNRSEWEEVSPMP 586
N G + ++DKI+ +GG + D V+ Y +EW+ VSPMP
Sbjct: 473 NHGLVFVKDKIFAVGGQNGLGGL-DNVEYYDIKLNEWKMVSPMP 515
Score = 56.2 bits (134), Expect = 8e-08
Identities = 55/227 (24%), Positives = 89/227 (39%), Gaps = 22/227 (9%)
Query: 262 LKSTNCFDIIMDAIKCVQGSGGLFPDARPSTTEKYIFIHKTEENGENQ-YTF-CYNIKSD 319
+K +C++++ D+ G E I+ E G + Y F CY+ +++
Sbjct: 349 IKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTE 408
Query: 320 SWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYCPV 379
SW P S L + I++ GG G L+ E Y AT+ CP
Sbjct: 409 SWHTKP-SMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP- 466
Query: 380 KNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSP 439
M R H V D++F +GG+ + L +VE Y+ EW VSP
Sbjct: 467 ---------MIEARKNHGLVFVKDKIFAVGGQN----GLGGLDNVEYYDIKLNEWKMVSP 513
Query: 440 LPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQW 486
+P + + +++YVL + L +YN TD+W
Sbjct: 514 MPWKGVTVKCAAVGSIVYVLAGFQGV-----GRLGHILEYNTETDKW 555
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 145 bits (367), Expect = 8e-35
Identities = 134/568 (23%), Positives = 243/568 (42%), Gaps = 41/568 (7%)
Query: 34 HGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSV 93
H +++L L R+ + D + + D I H+ VLA+ S +F+AMF N+ E+++ V
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
Query: 94 TITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSINLVN 153
+ A++A ++YAYTG I+ D VE ++ LQ+ + K C FL ++ N
Sbjct: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
Query: 154 CLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVPEEE 213
C+ + +++YG L+ A ++ +F + ++ +F E+ L + + +D LNV EE
Sbjct: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
Query: 214 MVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFDIIMD 273
V + SW K++++ RQKYL L+ VRL LS + L + C ++ +
Sbjct: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
Query: 274 AIKC-----VQGSGGLFPDARPSTTEKYIFIHKTEENGENQYTFC------YNIKSDSWK 322
A+K + S RP K + G++ C Y ++DSW
Sbjct: 257 ALKYHFMPEHRLSHQTVLMTRPRCAPKVL----CAVGGKSGLFACLDSVEMYFPQNDSWI 312
Query: 323 ILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYCPVKND 382
L + I + +K+++ GG VR + H+ + C+ P N
Sbjct: 313 GLAPLN-IPRYEFGICVLDQKVYVIGG----IATNVRPGVTIRKHE--NSVECWNPDTNT 365
Query: 383 FFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPR 442
+ + M R+ V+ L+ +GG S L VE Y P ++W V+P+
Sbjct: 366 WTSLERMNESRSTLGVVVLAGELYALGGYDGQS----YLQSVEKYIPKIRKWQPVAPMTT 421
Query: 443 GIYYPEASTCQNVIYVLGSEVEITDAFNPS-LDCFFKYNATTDQWSELVAEFGQFFH--- 498
A+ +IY +G + P+ ++ +Y+ + D W + + + H
Sbjct: 422 TRSCFAAAVLDGMIYAIG-------GYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGV 474
Query: 499 -ATLIKAVPVNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILG 557
L V + LS+ + Y P W + GA I++ +Y++G
Sbjct: 475 GVMLGFIFVVGGHNGVSHLSSIERYD--PHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVG 532
Query: 558 GDYAPDEITDEVQVYHSNRSEWEEVSPM 585
G ++ + VQ Y W + + M
Sbjct: 533 G-HSGSSYLNTVQKYDPISDTWLDSAGM 559
Score = 30.4 bits (67), Expect = 5.0
Identities = 40/194 (20%), Positives = 65/194 (33%), Gaps = 48/194 (24%)
Query: 405 LFVIGGKTRGSRDIKSLLD-VESYNPLSKEWISVSPLPRGIYYPEASTCQNVIYVLGSEV 463
L +GGK+ + + LD VE Y P + WI ++PL Y +YV+G
Sbjct: 285 LCAVGGKS----GLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGG-- 338
Query: 464 EITDAFNPSLDCFFKYNATTDQWSELVAEFGQFFHATLIKAVPVNCTLYICDLSTYKVYS 523
I P + K+ + + W+
Sbjct: 339 -IATNVRPGVT-IRKHENSVECWN------------------------------------ 360
Query: 524 FCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGDYAPDEITDEVQVYHSNRSEWEEVS 583
PDT W + G + + ++Y LGG Y V+ Y +W+ V+
Sbjct: 361 --PDTNTWTSLERMNESRSTLGVVVLAGELYALGG-YDGQSYLQSVEKYIPKIRKWQPVA 417
Query: 584 PMPRALTEFYCQVI 597
PM + F V+
Sbjct: 418 PMTTTRSCFAAAVL 431
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 145 bits (367), Expect = 8e-35
Identities = 132/598 (22%), Positives = 248/598 (41%), Gaps = 75/598 (12%)
Query: 28 FLVSEDHGQKILSVLQNFREQNVFYDFKIIMKD--EIIPCHRCVLAACSDFFRAMFEVNM 85
F S H +L R + + D ++ D EI P HR ++A+ SD+F+AMF M
Sbjct: 26 FFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGM 85
Query: 86 KERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFL 145
KE+D + + ++ +K +D+ YT K + DN++ + +SFLQ+ + C FL
Sbjct: 86 KEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 145
Query: 146 IKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESD 205
I ++L NC+++ I+++Y + + +F+ +F L + +FL++ F L L S+
Sbjct: 146 ISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSN 205
Query: 206 ELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKST 265
L E + K W + + R Y L++ +R ++ + L + + + +
Sbjct: 206 SLKHCTELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDN 264
Query: 266 NCFDIIMDAIKCVQGSGGLFPDARP-----STTEKYIFIHKTEENG-------ENQYTFC 313
C +++++A + + P +P T + H G ++
Sbjct: 265 TCVNLLLEA-----SNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRM 319
Query: 314 YNIKSDSWKILPQSHLIDLP--GSSLSSYGEKIFLTGG-----CKGKCCRTVRLHIAESY 366
Y+ ++ W+ L +D P ++ G +++ GG KGK
Sbjct: 320 YDERAQEWRSLAP---MDAPRYQHGIAVIGNFLYVVGGQSNYDTKGK------------- 363
Query: 367 HDATDQTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVES 426
A D + + P N + V+++ RT L+ +GG++ L VE
Sbjct: 364 -TAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAG----ELATVEC 418
Query: 427 YNPLSKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQW 486
YNP EW V+ + Y + ++Y+ G D F L CF + TD+W
Sbjct: 419 YNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITH--DTFQNELMCF---DPDTDKW 473
Query: 487 SELVAEFGQFFHATLIKAVPVNCT----LYICDLSTYKVYS----------FCPDTCVWK 532
+ T ++ + CT LY+ + ++ S + P W
Sbjct: 474 MQKAP-------MTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWT 526
Query: 533 GEGSFECAGFNAGAIGIEDKIYILGG-DYAPDEITDEVQVYHSNRSEWEEVSPMPRAL 589
+ + G E+KIY++GG + + + VQ Y + EW +V +P +L
Sbjct: 527 PIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESL 584
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 142 bits (359), Expect = 7e-34
Identities = 134/595 (22%), Positives = 246/595 (41%), Gaps = 75/595 (12%)
Query: 31 SEDHGQKILSVLQNFREQNVFYDFKIIM--KDEIIPCHRCVLAACSDFFRAMFEVNMKER 88
S H +L R + + D ++ D+ P HR ++A+ SD+F+AMF MKE+
Sbjct: 71 SNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQ 130
Query: 89 DDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKS 148
D + + +S ++ +D+ YT K + DN++ + +SFLQ+ + C FLI
Sbjct: 131 DLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISG 190
Query: 149 INLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELN 208
+ L NC+++ I+++Y T + + FV +F L + +FL++ F L L S+ L
Sbjct: 191 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLK 250
Query: 209 VPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCF 268
E + K W + E R + L++ +R ++ + L + + + + C
Sbjct: 251 HCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCV 309
Query: 269 DIIMDAIKCVQGSGGLFPDARP-----STTEKYIFIHKTEENG-------ENQYTFCYNI 316
+++++A + + P +P T + H G ++ Y+
Sbjct: 310 NLLLEA-----SNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDE 364
Query: 317 KSDSWKILPQSHLIDLP--GSSLSSYGEKIFLTGG-----CKGKCCRTVRLHIAESYHDA 369
K+ WK L +D P ++ G +++ GG KGK A
Sbjct: 365 KAHEWKSLAP---MDAPRYQHGIAVIGNFLYVVGGQSNYDTKGK--------------TA 407
Query: 370 TDQTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNP 429
D + + P N + V+++ RT L+ +GG+ L VE YNP
Sbjct: 408 VDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAG----ELPTVECYNP 463
Query: 430 LSKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSEL 489
+ EW V+ + Y + V+Y+ G D F L CF + TD+W +
Sbjct: 464 RTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITH--DTFQKELMCF---DPDTDKWIQK 518
Query: 490 VAEFGQFFHATLIKAVPVNCT----LYICDLSTYKVYS----------FCPDTCVWKGEG 535
T ++ + CT LY+ + ++ S + P W
Sbjct: 519 AP-------MTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIA 571
Query: 536 SFECAGFNAGAIGIEDKIYILGG-DYAPDEITDEVQVYHSNRSEWEEVSPMPRAL 589
+ + G E+KIY++GG + + + VQ Y ++ EW +V +P +L
Sbjct: 572 AMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESL 626
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,315,279
Number of Sequences: 37866
Number of extensions: 1035714
Number of successful extensions: 2868
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 154
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 2176
Number of HSP's gapped (non-prelim): 382
length of query: 612
length of database: 18,247,518
effective HSP length: 108
effective length of query: 504
effective length of database: 14,157,990
effective search space: 7135626960
effective search space used: 7135626960
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.