Search of human proteins with 37595754

Search of human proteins with 37595754

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|37595754 D-lactate dehydrogenase isoform 1 precursor [Homo
sapiens]
         (507 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|37595754 D-lactate dehydrogenase isoform 1 precursor [Homo sa...  1034   0.0  
gi|37595756 D-lactate dehydrogenase isoform 2 precursor [Homo sa...   966   0.0  
gi|119964728 D-2-hydroxyglutarate dehydrogenase precursor [Homo ...   154   1e-37
gi|4501993 alkyldihydroxyacetone phosphate synthase precursor [H...    91   2e-18
gi|27734909 kelch domain containing 8B [Homo sapiens]                  34   0.36 
gi|217416452 dynein, axonemal, intermediate polypeptide 2 [Homo ...    31   3.0  
gi|13375618 24-dehydrocholesterol reductase precursor [Homo sapi...    30   4.0  
gi|4826784 potassium voltage-gated channel, Shab-related subfami...    30   6.8  
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    29   8.8  

>gi|37595754 D-lactate dehydrogenase isoform 1 precursor [Homo
           sapiens]
          Length = 507

 Score = 1034 bits (2674), Expect = 0.0
 Identities = 507/507 (100%), Positives = 507/507 (100%)

Query: 1   MARLLRSATWELFPWRGYCSQKAKGELCRDFVEALKAVVGGSHVSTAAVVREQHGRDESV 60
           MARLLRSATWELFPWRGYCSQKAKGELCRDFVEALKAVVGGSHVSTAAVVREQHGRDESV
Sbjct: 1   MARLLRSATWELFPWRGYCSQKAKGELCRDFVEALKAVVGGSHVSTAAVVREQHGRDESV 60

Query: 61  HRCEPPDAVVWPQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCAVQGGVCVNLTHMD 120
           HRCEPPDAVVWPQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCAVQGGVCVNLTHMD
Sbjct: 61  HRCEPPDAVVWPQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCAVQGGVCVNLTHMD 120

Query: 121 RILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGADASLCGMAATGASGTNAVRY 180
           RILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGADASLCGMAATGASGTNAVRY
Sbjct: 121 RILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGADASLCGMAATGASGTNAVRY 180

Query: 181 GTMRDNVLNLEVVLPDGRLLHTAGRGRHFRFGFWPEIPHHTAWYSPCVSLGRRKSAAGYN 240
           GTMRDNVLNLEVVLPDGRLLHTAGRGRHFRFGFWPEIPHHTAWYSPCVSLGRRKSAAGYN
Sbjct: 181 GTMRDNVLNLEVVLPDGRLLHTAGRGRHFRFGFWPEIPHHTAWYSPCVSLGRRKSAAGYN 240

Query: 241 LTGLFVGSEGTLGLITATTLRLHPAPEATVAATCAFPSVQAAVDSTVHILQAAVPVARIE 300
           LTGLFVGSEGTLGLITATTLRLHPAPEATVAATCAFPSVQAAVDSTVHILQAAVPVARIE
Sbjct: 241 LTGLFVGSEGTLGLITATTLRLHPAPEATVAATCAFPSVQAAVDSTVHILQAAVPVARIE 300

Query: 301 FLDEVMMDACNRYSKLNCLVAPTLFLEFHGSQQALEEQLQRTEEIVQQNGASDFSWAKEA 360
           FLDEVMMDACNRYSKLNCLVAPTLFLEFHGSQQALEEQLQRTEEIVQQNGASDFSWAKEA
Sbjct: 301 FLDEVMMDACNRYSKLNCLVAPTLFLEFHGSQQALEEQLQRTEEIVQQNGASDFSWAKEA 360

Query: 361 EERSRLWTARHNAWYAALATRPGCKGYSTDVCVPISRLPEIVVQTKEDLNASGLTGSIVG 420
           EERSRLWTARHNAWYAALATRPGCKGYSTDVCVPISRLPEIVVQTKEDLNASGLTGSIVG
Sbjct: 361 EERSRLWTARHNAWYAALATRPGCKGYSTDVCVPISRLPEIVVQTKEDLNASGLTGSIVG 420

Query: 421 HVGDGNFHCILLVNPDDAEELGRVKAFAEQLGRRALALHGTCTGEHGIGMGKRQLLQEEV 480
           HVGDGNFHCILLVNPDDAEELGRVKAFAEQLGRRALALHGTCTGEHGIGMGKRQLLQEEV
Sbjct: 421 HVGDGNFHCILLVNPDDAEELGRVKAFAEQLGRRALALHGTCTGEHGIGMGKRQLLQEEV 480

Query: 481 GAVGVETMRQLKAVLDPQGLMNPGKVL 507
           GAVGVETMRQLKAVLDPQGLMNPGKVL
Sbjct: 481 GAVGVETMRQLKAVLDPQGLMNPGKVL 507


>gi|37595756 D-lactate dehydrogenase isoform 2 precursor [Homo
           sapiens]
          Length = 484

 Score =  966 bits (2497), Expect = 0.0
 Identities = 484/507 (95%), Positives = 484/507 (95%), Gaps = 23/507 (4%)

Query: 1   MARLLRSATWELFPWRGYCSQKAKGELCRDFVEALKAVVGGSHVSTAAVVREQHGRDESV 60
           MARLLRSATWELFPWRGYCSQKAKGELCRDFVEALKAVVGGSHVSTAAVVREQHGRDESV
Sbjct: 1   MARLLRSATWELFPWRGYCSQKAKGELCRDFVEALKAVVGGSHVSTAAVVREQHGRDESV 60

Query: 61  HRCEPPDAVVWPQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCAVQGGVCVNLTHMD 120
           HRCEPPDAVVWPQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCAVQGGVCVNLTHMD
Sbjct: 61  HRCEPPDAVVWPQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCAVQGGVCVNLTHMD 120

Query: 121 RILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGADASLCGMAATGASGTNAVRY 180
           RILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGADASLCGMAATGASGTNAVRY
Sbjct: 121 RILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGADASLCGMAATGASGTNAVRY 180

Query: 181 GTMRDNVLNLEVVLPDGRLLHTAGRGRHFRFGFWPEIPHHTAWYSPCVSLGRRKSAAGYN 240
           GTMRDNVLNLEVVLPDGRLLHTAGRGRHFR                       KSAAGYN
Sbjct: 181 GTMRDNVLNLEVVLPDGRLLHTAGRGRHFR-----------------------KSAAGYN 217

Query: 241 LTGLFVGSEGTLGLITATTLRLHPAPEATVAATCAFPSVQAAVDSTVHILQAAVPVARIE 300
           LTGLFVGSEGTLGLITATTLRLHPAPEATVAATCAFPSVQAAVDSTVHILQAAVPVARIE
Sbjct: 218 LTGLFVGSEGTLGLITATTLRLHPAPEATVAATCAFPSVQAAVDSTVHILQAAVPVARIE 277

Query: 301 FLDEVMMDACNRYSKLNCLVAPTLFLEFHGSQQALEEQLQRTEEIVQQNGASDFSWAKEA 360
           FLDEVMMDACNRYSKLNCLVAPTLFLEFHGSQQALEEQLQRTEEIVQQNGASDFSWAKEA
Sbjct: 278 FLDEVMMDACNRYSKLNCLVAPTLFLEFHGSQQALEEQLQRTEEIVQQNGASDFSWAKEA 337

Query: 361 EERSRLWTARHNAWYAALATRPGCKGYSTDVCVPISRLPEIVVQTKEDLNASGLTGSIVG 420
           EERSRLWTARHNAWYAALATRPGCKGYSTDVCVPISRLPEIVVQTKEDLNASGLTGSIVG
Sbjct: 338 EERSRLWTARHNAWYAALATRPGCKGYSTDVCVPISRLPEIVVQTKEDLNASGLTGSIVG 397

Query: 421 HVGDGNFHCILLVNPDDAEELGRVKAFAEQLGRRALALHGTCTGEHGIGMGKRQLLQEEV 480
           HVGDGNFHCILLVNPDDAEELGRVKAFAEQLGRRALALHGTCTGEHGIGMGKRQLLQEEV
Sbjct: 398 HVGDGNFHCILLVNPDDAEELGRVKAFAEQLGRRALALHGTCTGEHGIGMGKRQLLQEEV 457

Query: 481 GAVGVETMRQLKAVLDPQGLMNPGKVL 507
           GAVGVETMRQLKAVLDPQGLMNPGKVL
Sbjct: 458 GAVGVETMRQLKAVLDPQGLMNPGKVL 484


>gi|119964728 D-2-hydroxyglutarate dehydrogenase precursor [Homo
           sapiens]
          Length = 521

 Score =  154 bits (390), Expect = 1e-37
 Identities = 127/445 (28%), Positives = 199/445 (44%), Gaps = 42/445 (9%)

Query: 72  PQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCAVQGGVCVNLTHMDRILELNQEDFS 131
           P+  E+VS +   C+ + + + P G  TG+ GG   V   + ++   M+R+L  +     
Sbjct: 106 PRTSEEVSHILRHCHERNLAVNPQGGNTGMVGGSVPVFDEIILSTARMNRVLSFHSVSGI 165

Query: 132 VVVEPGVTRKALNAHLRDSGLWFPVDPGADAS--LCGMAATGASGTNAVRYGTMRDNVLN 189
           +V + G   + L+ ++ +     P+D GA  S  + G  AT A G   +RYG++   VL 
Sbjct: 166 LVCQAGCVLEELSRYVEERDFIMPLDLGAKGSCHIGGNVATNAGGLRFLRYGSLHGTVLG 225

Query: 190 LEVVLPDGRLLHTAGRGRHFRFGFWPEIPHHTAWYSPCVSLGRRKSAAGYNLTGLFVGSE 249
           LEVVL DG +L                          C++   RK   GY+L  LF+GSE
Sbjct: 226 LEVVLADGTVL-------------------------DCLT-SLRKDNTGYDLKQLFIGSE 259

Query: 250 GTLGLITATTLRLHPAPEATVAATCAFPSVQAAVD--STVHILQAAVPVARIEFLDEVMM 307
           GTLG+IT  ++   P P A   A    P     +   ST   +   + ++  EF+D V M
Sbjct: 260 GTLGIITTVSILCPPKPRAVNVAFLGCPGFAEVLQTFSTCKGMLGEI-LSAFEFMDAVCM 318

Query: 308 DACNRYSKLNCLVAPTLF---LEFHGSQQALE-EQLQRTEEIVQQNG-ASDFSWAKEAEE 362
               R+  L   V  + F   +E  GS    + E+L    E    +G  +D + A +  +
Sbjct: 319 QLVGRHLHLASPVQESPFYVLIETSGSNAGHDAEKLGHFLEHALGSGLVTDGTMATDQRK 378

Query: 363 RSRLWTARHNAWYAALATRPGCKGYSTDVCVPISRLPEIVVQTKEDLNASGLTGSIVGHV 422
              LW  R     A   +R G   Y  D+ +P+ RL +IV   +  L          GH+
Sbjct: 379 VKMLWALRERITEA--LSRDGYV-YKYDLSLPVERLYDIVTDLRARLGPHAKHVVGYGHL 435

Query: 423 GDGNFHCILLVNPDDAEELGRVKAFAEQLGRRALALHGTCTGEHGIGMGKRQLLQEEVGA 482
           GDGN H  +     +A     + A    +        G+ + EHG+G  KR +L      
Sbjct: 436 GDGNLHLNVTA---EAFSPSLLAALEPHVYEWTAGQQGSVSAEHGVGFRKRDVLGYSKPP 492

Query: 483 VGVETMRQLKAVLDPQGLMNPGKVL 507
             ++ M+QLKA+LDP+G++NP K L
Sbjct: 493 GALQLMQQLKALLDPKGILNPYKTL 517


>gi|4501993 alkyldihydroxyacetone phosphate synthase precursor [Homo
           sapiens]
          Length = 658

 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 106/484 (21%), Positives = 193/484 (39%), Gaps = 73/484 (15%)

Query: 66  PDAVVWPQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCA----VQGGVCVNLTHMDR 121
           PD V+WP   + V ++  L  +  + IIP G GT +  G+       +  + ++ + M+R
Sbjct: 206 PDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYGLMCPADETRTIISLDTSQMNR 265

Query: 122 ILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGA--DASLCGMAATGASGTNAVR 179
           IL +++ + +  VE G+T + L   L++SG     +P +   +++ G  +T ASG     
Sbjct: 266 ILWVDENNLTAHVEAGITGQELERQLKESGYCTGHEPDSLEFSTVGGWVSTRASGMKKNI 325

Query: 180 YGTMRDNVLNLEVVLPDGRLLHTAGRGRHFRFGFWPEIPHHTAWYSPCVSLGRRKSAAGY 239
           YG + D V+++++V P G ++  + +G     G  P+I H                    
Sbjct: 326 YGNIEDLVVHIKMVTPRG-IIEKSCQGPRMSTG--PDIHH-------------------- 362

Query: 240 NLTGLFVGSEGTLGLITATTLRLHPAPEATVAATCAFPSVQAAVDSTV------------ 287
                 +GSEGTLG+IT  T+++ P PE     + AFP+ +  V                
Sbjct: 363 ----FIMGSEGTLGVITEATIKIRPVPEYQKYGSVAFPNFEQGVACLREIAKQRCAPASI 418

Query: 288 -----------HILQAAVPVARIEFLDEVMMDACNRYSKLNCLVAPTLFLEFHGSQQALE 336
                      H L+  V      FLD +      ++   +        L F G ++ + 
Sbjct: 419 RLMDNKQFQFGHALKPQVSSIFTSFLDGLKKFYITKFKGFDPNQLSVATLLFEGDREKVL 478

Query: 337 EQLQRTEEIVQQNGASDFSWAKEAEERSRLWTARHNAWYAALATRPGCKGYSTDVCVPIS 396
           +  ++  +I  + G    +  ++  +R  L T    A+   LA      G S +   P  
Sbjct: 479 QHEKQVYDIAAKFGG--LAAGEDNGQRGYLLTYVI-AYIRDLALEYYVLGESFETSAPWD 535

Query: 397 RLPEIVVQTKEDLNASGLTGSI---------VGHVGDGNFHCILLVNPDDAEELGRVKAF 447
           R+ ++    KE +        +         V    D    CI      +   +      
Sbjct: 536 RVVDLCRNVKERITRECKEKGVQFAPFSTCRVTQTYDAGA-CIYFYFAFNYRGISDPLTV 594

Query: 448 AEQLGRRA----LALHGTCTGEHGIGMGKRQLLQEEVGAVGVETMRQLKAVLDPQGLMNP 503
            EQ    A    LA  G+ +  HG+G  ++Q L+E +  VG   ++ +K  +DP  +   
Sbjct: 595 FEQTEAAAREEILANGGSLSHHHGVGKLRKQWLKESISDVGFGMLKSVKEYVDPNNIFGN 654

Query: 504 GKVL 507
             +L
Sbjct: 655 RNLL 658


>gi|27734909 kelch domain containing 8B [Homo sapiens]
          Length = 354

 Score = 33.9 bits (76), Expect = 0.36
 Identities = 27/103 (26%), Positives = 40/103 (38%)

Query: 202 TAGRGRHFRFGFWPEIPHHTAWYSPCVSLGRRKSAAGYNLTGLFVGSEGTLGLITATTLR 261
           +AG GR F +  +P +P    + +     G      G    GL + +  TL + + T L 
Sbjct: 2   SAGGGRAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLA 61

Query: 262 LHPAPEATVAATCAFPSVQAAVDSTVHILQAAVPVARIEFLDE 304
           L P P A   A       Q  V   V  +Q+ V       +DE
Sbjct: 62  LAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDE 104


>gi|217416452 dynein, axonemal, intermediate polypeptide 2 [Homo
           sapiens]
          Length = 605

 Score = 30.8 bits (68), Expect = 3.0
 Identities = 19/92 (20%), Positives = 40/92 (43%)

Query: 291 QAAVPVARIEFLDEVMMDACNRYSKLNCLVAPTLFLEFHGSQQALEEQLQRTEEIVQQNG 350
           ++ +P   +   ++ ++ +CNR +K +       F   HG   AL+      +  +    
Sbjct: 326 ESTLPTKFMVGTEQGIVISCNRKAKTSAEKIVCTFPGHHGPIYALQRNPFYPKNFLTVGD 385

Query: 351 ASDFSWAKEAEERSRLWTARHNAWYAALATRP 382
            +   W++++ E S +WT  H A+    A  P
Sbjct: 386 WTARIWSEDSRESSIMWTKYHMAYLTDAAWSP 417


>gi|13375618 24-dehydrocholesterol reductase precursor [Homo
           sapiens]
          Length = 516

 Score = 30.4 bits (67), Expect = 4.0
 Identities = 29/87 (33%), Positives = 41/87 (47%), Gaps = 4/87 (4%)

Query: 112 VCVNLTHMDRILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGADASLCGMAATG 171
           + +NL  MD ILE++ +   V VEP VT   + A L   G   PV P  D    G    G
Sbjct: 114 IMINL--MD-ILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMG 170

Query: 172 AS-GTNAVRYGTMRDNVLNLEVVLPDG 197
               +++ +YG  +      E+VL DG
Sbjct: 171 TGIESSSHKYGLFQHICTAYELVLADG 197


>gi|4826784 potassium voltage-gated channel, Shab-related subfamily,
           member 1 [Homo sapiens]
          Length = 858

 Score = 29.6 bits (65), Expect = 6.8
 Identities = 14/66 (21%), Positives = 32/66 (48%), Gaps = 13/66 (19%)

Query: 302 LDEVMMDACNRYSKLNCLVAPTLFLEFHGSQQALEEQLQRTEEIVQQNGASDFSWAKEAE 361
           +DE+ +++C +               +H  ++ + E+L+R  E +++    +F     AE
Sbjct: 124 IDEIYLESCCQ-------------ARYHQKKEQMNEELKREAETLREREGEEFDNTCCAE 170

Query: 362 ERSRLW 367
           +R +LW
Sbjct: 171 KRKKLW 176


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 29.3 bits (64), Expect = 8.8
 Identities = 20/50 (40%), Positives = 24/50 (48%), Gaps = 7/50 (14%)

Query: 199  LLHTAGRGRHFRFGFW-----PEIPHHTAWYSPCVSLGRRKSAAGYNLTG 243
            LLHTAG G H + G         +PH  A   P VSLG +  +   NL G
Sbjct: 4107 LLHTAGGGSHGQLGSGSSSEASSVPHLLA--QPSVSLGDQPGSMTQNLLG 4154


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,803,075
Number of Sequences: 37866
Number of extensions: 880100
Number of successful extensions: 2093
Number of sequences better than 10.0: 9
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 2080
Number of HSP's gapped (non-prelim): 11
length of query: 507
length of database: 18,247,518
effective HSP length: 107
effective length of query: 400
effective length of database: 14,195,856
effective search space: 5678342400
effective search space used: 5678342400
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.