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Search of human proteins with 34101268
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34101268 kelch-like 8 [Homo sapiens]
(620 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34101268 kelch-like 8 [Homo sapiens] 1273 0.0
gi|40807500 kelch-like 20 [Homo sapiens] 460 e-129
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 416 e-116
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 416 e-116
gi|14780904 kelch-like 1 protein [Homo sapiens] 414 e-115
gi|11056006 kelch-like 12 [Homo sapiens] 409 e-114
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 400 e-111
gi|38194229 kelch-like 17 [Homo sapiens] 399 e-111
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 397 e-110
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 395 e-110
gi|55925604 kelch-like 18 [Homo sapiens] 380 e-105
gi|166235129 kelch-like 3 [Homo sapiens] 379 e-105
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 375 e-104
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 375 e-104
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 352 6e-97
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 340 2e-93
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 301 1e-81
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 301 1e-81
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 289 5e-78
gi|148664209 kelch-like 10 [Homo sapiens] 285 1e-76
gi|223890235 intracisternal A particle-promoted polypeptide isof... 275 7e-74
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 243 5e-64
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 241 1e-63
gi|40018614 DRE1 protein [Homo sapiens] 232 9e-61
gi|24475847 influenza virus NS1A binding protein [Homo sapiens] 218 1e-56
gi|40255071 kelch-like 23 [Homo sapiens] 209 5e-54
gi|31542246 kelch-like 36 [Homo sapiens] 209 8e-54
gi|55925608 kelch-like 21 [Homo sapiens] 208 1e-53
gi|109150407 kelch-like 6 [Homo sapiens] 207 3e-53
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 205 9e-53
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 1273 bits (3293), Expect = 0.0
Identities = 620/620 (100%), Positives = 620/620 (100%)
Query: 1 MASDSMSSKQARNHITKGKRQQQHQQIKNRSSISDGDGEDSFIFEANEAWKDFHGSLLRF 60
MASDSMSSKQARNHITKGKRQQQHQQIKNRSSISDGDGEDSFIFEANEAWKDFHGSLLRF
Sbjct: 1 MASDSMSSKQARNHITKGKRQQQHQQIKNRSSISDGDGEDSFIFEANEAWKDFHGSLLRF 60
Query: 61 YENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIED 120
YENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIED
Sbjct: 61 YENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIED 120
Query: 121 LVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHN 180
LVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHN
Sbjct: 121 LVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHN 180
Query: 181 RIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLA 240
RIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLA
Sbjct: 181 RIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLA 240
Query: 241 NPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRA 300
NPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRA
Sbjct: 241 NPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRA 300
Query: 301 VPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVG 360
VPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVG
Sbjct: 301 VPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVG 360
Query: 361 VISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGG 420
VISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGG
Sbjct: 361 VISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGG 420
Query: 421 LDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERY 480
LDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERY
Sbjct: 421 LDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERY 480
Query: 481 DPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAAL 540
DPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAAL
Sbjct: 481 DPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAAL 540
Query: 541 TTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCS 600
TTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCS
Sbjct: 541 TTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCS 600
Query: 601 CLTSQIRDVGHGSNNVVDCM 620
CLTSQIRDVGHGSNNVVDCM
Sbjct: 601 CLTSQIRDVGHGSNNVVDCM 620
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 460 bits (1183), Expect = e-129
Identities = 243/546 (44%), Positives = 346/546 (63%), Gaps = 9/546 (1%)
Query: 56 SLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDG 115
+LLR ++ ELCDV L VG+K I H+++L+ PYFRAMF E+AE++QT + IRD D
Sbjct: 59 NLLR--KHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDE 116
Query: 116 DAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAF 175
A+E L+ F Y+S++T+ NVQ LL AAC+LQ+ + ACCE++K PSNCL +RAF
Sbjct: 117 RAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAF 176
Query: 176 AESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAI 235
A++H+ +L+ +AD++ +F EV+E E+F+ + L ++SS +LN+ +E+QV+NA +
Sbjct: 177 ADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVM 236
Query: 236 KWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLH 295
W+ + Q L + L VRLPLL FL+G V + ++K + +CRDL+DEA+NY L
Sbjct: 237 AWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLL 296
Query: 296 LSSRAVPDFEYSIRTTPRK--HTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMN 353
R + RT PRK VLF VGG SGD S+E Y N W M+
Sbjct: 297 PQERPLMQ---GPRTRPRKPIRCGEVLFAVGG-WCSGDAISSVERYDPQTNEWRMVASMS 352
Query: 354 SRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMK-ASMNTKRRGIALASLG 412
RR VGV ++ +YAVGGHDG+ +L S+E +DP TN+W A +T R + +A LG
Sbjct: 353 KRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLG 412
Query: 413 GPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMA 472
G +YA+GG D +C N VERYD + ++W+ VA M+T R GV L +YAVGG+DG +
Sbjct: 413 GFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTS 472
Query: 473 SLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSN 532
L++VERY+P ++W + MG RR G + +Y VGG DD + LSS ERY+PR+N
Sbjct: 473 PLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTN 532
Query: 533 KWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRA 592
+W V A+T+ R GVG+A V G++ AVGG +G YL T+E FDP N W L G +++ R
Sbjct: 533 QWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRL 592
Query: 593 GAGVAV 598
G GV V
Sbjct: 593 GGGVGV 598
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 416 bits (1070), Expect = e-116
Identities = 226/565 (40%), Positives = 331/565 (58%), Gaps = 16/565 (2%)
Query: 40 DSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSE 99
D F N A + F + + + +LCDV L G + I H+LVL+ V YF AMF ++
Sbjct: 148 DEFFQALNHAEQTFK-KMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTND 206
Query: 100 MAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEY 159
+ EA+Q I++ + +++ L+++ Y+ RL L DN++ LL AC+LQ+ V ACC++
Sbjct: 207 VREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKF 266
Query: 160 MKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSS 219
+ HPSNCL +R+FA++ DL +A Y +HF EV+ ++FV + + KLL+S
Sbjct: 267 LMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLAS 326
Query: 220 SDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQN 279
D+NI NE+ + NA + W+ + + K L + LA +RLPLL FL + + + +
Sbjct: 327 DDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDD 385
Query: 280 LKCRDLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECY 339
++C+ L+ EA YHL R + S RT PRK T G LF VGG S SIE Y
Sbjct: 386 IECQKLIMEAMKYHLLPERRPMLQ---SPRTKPRKSTVGTLFAVGGM-DSTKGATSIEKY 441
Query: 340 SINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASM 399
+ N W MN RR GV ++ K+Y VGG DG + L ++E ++P T W + M
Sbjct: 442 DLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPM 501
Query: 400 NTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALV 459
+T R G+ +A L GP+YA+GG D + N VER+D ++ QW+ VA M+TPR VG L
Sbjct: 502 STHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLS 561
Query: 460 NHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNS 519
+YAVGG DG + L SVE +DPH +KW +M +RR G GV+ +G LY +GG D +
Sbjct: 562 GKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHD--A 619
Query: 520 PLSS--------VERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTV 571
P S+ VERYDP+++ W VA+++ R VG+ + K++AVGG++G AYLNTV
Sbjct: 620 PASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTV 679
Query: 572 EAFDPVLNRWELVGSVSHCRAGAGV 596
EA+DP N W V + RAGA V
Sbjct: 680 EAYDPQTNEWTQVAPLCLGRAGACV 704
Score = 119 bits (297), Expect = 1e-26
Identities = 60/142 (42%), Positives = 87/142 (61%)
Query: 459 VNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDN 518
V ++AVGG D +S+E+YD + W V M RR GV+ L LYVVGG D
Sbjct: 420 VGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGL 479
Query: 519 SPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVL 578
L++VE Y+P++ W + ++T R G+G+A + G ++AVGGH+G +YLNTVE +DP
Sbjct: 480 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQA 539
Query: 579 NRWELVGSVSHCRAGAGVAVCS 600
+W V ++S R+ GVAV S
Sbjct: 540 RQWNFVATMSTPRSTVGVAVLS 561
Score = 32.3 bits (72), Expect = 1.3
Identities = 21/59 (35%), Positives = 31/59 (52%), Gaps = 1/59 (1%)
Query: 540 LTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAV 598
L +PR +TV G +FAVGG + ++E +D N W V +++ R GVAV
Sbjct: 408 LQSPRTKPRKSTV-GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAV 465
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 416 bits (1070), Expect = e-116
Identities = 226/565 (40%), Positives = 331/565 (58%), Gaps = 16/565 (2%)
Query: 40 DSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSE 99
D F N A + F + + + +LCDV L G + I H+LVL+ V YF AMF ++
Sbjct: 194 DEFFQALNHAEQTFK-KMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTND 252
Query: 100 MAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEY 159
+ EA+Q I++ + +++ L+++ Y+ RL L DN++ LL AC+LQ+ V ACC++
Sbjct: 253 VREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKF 312
Query: 160 MKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSS 219
+ HPSNCL +R+FA++ DL +A Y +HF EV+ ++FV + + KLL+S
Sbjct: 313 LMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLAS 372
Query: 220 SDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQN 279
D+NI NE+ + NA + W+ + + K L + LA +RLPLL FL + + + +
Sbjct: 373 DDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDD 431
Query: 280 LKCRDLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECY 339
++C+ L+ EA YHL R + S RT PRK T G LF VGG S SIE Y
Sbjct: 432 IECQKLIMEAMKYHLLPERRPMLQ---SPRTKPRKSTVGTLFAVGGM-DSTKGATSIEKY 487
Query: 340 SINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASM 399
+ N W MN RR GV ++ K+Y VGG DG + L ++E ++P T W + M
Sbjct: 488 DLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPM 547
Query: 400 NTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALV 459
+T R G+ +A L GP+YA+GG D + N VER+D ++ QW+ VA M+TPR VG L
Sbjct: 548 STHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLS 607
Query: 460 NHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNS 519
+YAVGG DG + L SVE +DPH +KW +M +RR G GV+ +G LY +GG D +
Sbjct: 608 GKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHD--A 665
Query: 520 PLSS--------VERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTV 571
P S+ VERYDP+++ W VA+++ R VG+ + K++AVGG++G AYLNTV
Sbjct: 666 PASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTV 725
Query: 572 EAFDPVLNRWELVGSVSHCRAGAGV 596
EA+DP N W V + RAGA V
Sbjct: 726 EAYDPQTNEWTQVAPLCLGRAGACV 750
Score = 119 bits (297), Expect = 1e-26
Identities = 60/142 (42%), Positives = 87/142 (61%)
Query: 459 VNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDN 518
V ++AVGG D +S+E+YD + W V M RR GV+ L LYVVGG D
Sbjct: 466 VGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGL 525
Query: 519 SPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVL 578
L++VE Y+P++ W + ++T R G+G+A + G ++AVGGH+G +YLNTVE +DP
Sbjct: 526 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQA 585
Query: 579 NRWELVGSVSHCRAGAGVAVCS 600
+W V ++S R+ GVAV S
Sbjct: 586 RQWNFVATMSTPRSTVGVAVLS 607
Score = 32.3 bits (72), Expect = 1.3
Identities = 21/59 (35%), Positives = 31/59 (52%), Gaps = 1/59 (1%)
Query: 540 LTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAV 598
L +PR +TV G +FAVGG + ++E +D N W V +++ R GVAV
Sbjct: 454 LQSPRTKPRKSTV-GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAV 511
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 414 bits (1065), Expect = e-115
Identities = 225/570 (39%), Positives = 331/570 (58%), Gaps = 12/570 (2%)
Query: 35 DGDGEDSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRA 94
D + F + A + F + + + +LCDV L VG++ I H+LVL+ V YF A
Sbjct: 181 DSSSSEEFYQAVHHAEQTFR-KMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAA 239
Query: 95 MFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVAR 154
MF S++ EAKQ I++ D +A+ DLV+F Y+ L L D ++ LL AAC+LQ+ V
Sbjct: 240 MFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVE 299
Query: 155 ACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLH 214
CC ++ HPSNCL +RAFA++ I+LM +A Y ++ EV+ ++F+ + + LH
Sbjct: 300 VCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELH 359
Query: 215 KLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQ 274
KLL+S D+N+ +E+ +++A + W+ + Q L LA +RLPLLP L +
Sbjct: 360 KLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHA 418
Query: 275 IVKQNLKCRDLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFR 334
+ K +L+C+ L+ EA YHL R + S RT PRK T G L+ VGG +
Sbjct: 419 LFKNDLECQKLILEAMKYHLLPERRTLMQ---SPRTKPRKSTVGTLYAVGGMDNNKGA-T 474
Query: 335 SIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWM 394
+IE Y + N W MN RR GV ++ K++ +GG DG + L ++E ++P T W
Sbjct: 475 TIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWT 534
Query: 395 MKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVG 454
+ M+T R G+ + L GPIYA+GG D + N VER+D +S QW+ VA M+ R VG
Sbjct: 535 VLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVG 594
Query: 455 SVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGG 514
AL +Y+VGG DG + LSS+E YDPH +KW M +RR G GV+ G LY VGG
Sbjct: 595 VAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGG 654
Query: 515 FDDNSP------LSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYL 568
D + L VERYDP+++ W VA L+ PR VG+ + +++AVGG++G YL
Sbjct: 655 HDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYL 714
Query: 569 NTVEAFDPVLNRWELVGSVSHCRAGAGVAV 598
NT+E++DP N W + S++ RAGA V V
Sbjct: 715 NTMESYDPQTNEWTQMASLNIGRAGACVVV 744
Score = 154 bits (389), Expect = 2e-37
Identities = 70/187 (37%), Positives = 116/187 (62%)
Query: 413 GPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMA 472
G +YA+GG+D+N +E+YD+ ++ W MN R G + + ++ +GG DG+
Sbjct: 459 GTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLK 518
Query: 473 SLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSN 532
+L++VE Y+P W + M R G GV+ L G +Y VGG D S L++VER+DP+S
Sbjct: 519 TLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQ 578
Query: 533 KWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRA 592
+W +VA+++ R VG+A + GK+++VGG +G++ L+++E +DP N+W + + R
Sbjct: 579 QWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRG 638
Query: 593 GAGVAVC 599
G GVA C
Sbjct: 639 GVGVATC 645
Score = 63.2 bits (152), Expect = 7e-10
Identities = 34/102 (33%), Positives = 51/102 (50%), Gaps = 5/102 (4%)
Query: 318 GVLFCVGGRGGSGDPFRS-----IECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVG 372
G L+ VGG S +E Y ++W ++ R VGV + ++YAVG
Sbjct: 647 GFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVG 706
Query: 373 GHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGP 414
G+DG +L +ME +DP TN+W AS+N R G + + P
Sbjct: 707 GYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP 748
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 409 bits (1050), Expect = e-114
Identities = 210/551 (38%), Positives = 320/551 (58%), Gaps = 6/551 (1%)
Query: 51 KDFHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEI 110
K S+ ++ LCDVTL+V K H++VLA YF AMF SE++E + ++I
Sbjct: 17 KSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDI 76
Query: 111 RDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCL 170
+ +E L+ FVY+ + +TV+NVQ LL AAC+LQ++ V +ACCE+++ PSNCL
Sbjct: 77 QGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCL 136
Query: 171 AVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQV 230
+R FAE+HN +DLM A+ ++ HF EVV+ E+F+ +S + KL+ ++ +++E+ V
Sbjct: 137 GIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPV 196
Query: 231 YNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEAR 290
+ A I W+ + + L L VR+PLL ++ V+ E ++ +L+CRDL+DEA+
Sbjct: 197 FEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAK 256
Query: 291 NYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGP 350
+HL R+ RT R VL VGG G P +E Y W F P
Sbjct: 257 KFHLRPELRSQMQ---GPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLP 313
Query: 351 EMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNK---WMMKASMNTKRRGIA 407
+ +RR+V +S+ ++Y +GG+DG L S+E D ++ W A MN +R
Sbjct: 314 SITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAG 373
Query: 408 LASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGG 467
+LG IY GG D + +ERYD DQWS + M T R G G V +Y +GG
Sbjct: 374 ATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGG 433
Query: 468 NDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERY 527
DG+ L+SVE+YDPH W V M +R+G GV+ L+ +YVVGGFD + LSSVE Y
Sbjct: 434 YDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAY 493
Query: 528 DPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSV 587
+ R++ W V ++TTPR VG + G+++A+ G++GN+ L+++E +DP+++ WE+V S+
Sbjct: 494 NIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSM 553
Query: 588 SHCRAGAGVAV 598
R AGV V
Sbjct: 554 GTQRCDAGVCV 564
Score = 85.5 bits (210), Expect = 1e-16
Identities = 53/160 (33%), Positives = 81/160 (50%), Gaps = 9/160 (5%)
Query: 445 PMNTPRGGVGSVALVNHVYAVGGNDGMAS-LSSVERYDPHLDKWIEVKEMGQRRAGNGVS 503
P R G V LV VGG S + VE+YDP +W + + ++R
Sbjct: 271 PRTRARLGANEVLLV-----VGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASV 325
Query: 504 KLHGCLYVVGGFDDNSPLSSVERYDPRSNK---WDYVAALTTPRGGVGIATVMGKIFAVG 560
LH +YV+GG+D S LSSVE D +++ W VA + RG G T+ I+ G
Sbjct: 326 SLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSG 385
Query: 561 GHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCS 600
G +G+ ++E +DP +++W ++G + R GAG+ V S
Sbjct: 386 GFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVAS 425
Score = 59.3 bits (142), Expect = 1e-08
Identities = 38/126 (30%), Positives = 67/126 (53%), Gaps = 5/126 (3%)
Query: 483 HLDKWIEVKEMGQR-RAGNGVSKLHGCLYVVGGF-DDNSPLSSVERYDPRSNKWDYVAAL 540
HL + + G R RA G +++ L VVGGF SP+ VE+YDP++ +W ++ ++
Sbjct: 259 HLRPELRSQMQGPRTRARLGANEV---LLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSI 315
Query: 541 TTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCS 600
T R V ++ +I+ +GG++G + L++VE D + + SV+ G+A +
Sbjct: 316 TRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGAT 375
Query: 601 CLTSQI 606
L I
Sbjct: 376 TLGDMI 381
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 400 bits (1029), Expect = e-111
Identities = 216/547 (39%), Positives = 321/547 (58%), Gaps = 15/547 (2%)
Query: 60 FYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIE 119
+ + +LCDV L G I H+LVL+ V YF AMF +++ EAKQ + + D +A+
Sbjct: 175 YLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALN 234
Query: 120 DLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESH 179
LV++ Y+ L L D ++ LL AAC+LQ+ V C ++ HPSNCL +R+F ++
Sbjct: 235 SLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQ 294
Query: 180 NRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLL 239
+L+++A +Y +HF EV++ ++F+ + + KLL S D+N+ +E+ +++A ++W+
Sbjct: 295 GCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVG 354
Query: 240 ANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSR 299
+ Q+ L L+ +RLPLLP L + +L+C+ LL EA YHL R
Sbjct: 355 HDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTG-DLECQKLLMEAMKYHLLPERR 413
Query: 300 AVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHV 359
++ S RT PRK T G L+ VGG +IE Y + NSW MN RR
Sbjct: 414 SMMQ---SPRTKPRKSTVGALYAVGGMDAMKGT-TTIEKYDLRTNSWLHIGTMNGRRLQF 469
Query: 360 GVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIG 419
GV ++ K+Y VGG DG + L ++E F+P+ W + M+T R G+ +A+L GP+YA+G
Sbjct: 470 GVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
Query: 420 GLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVER 479
G D + N VER+D E QW+ VA M+TPR VG VAL N +YA+GG DG + L S+E
Sbjct: 530 GHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 589
Query: 480 YDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSS--------VERYDPRS 531
+DPH +KW M +RR G GV+ +G LYVVGG D +P S+ VERYDP+
Sbjct: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHD--APASNHCSRLSDCVERYDPKG 647
Query: 532 NKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCR 591
+ W VA L+ PR V + + K++ VGG++G+ YLNTVE++D N W+ V+ R
Sbjct: 648 DSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGR 707
Query: 592 AGAGVAV 598
AGA V V
Sbjct: 708 AGACVVV 714
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 399 bits (1024), Expect = e-111
Identities = 215/555 (38%), Positives = 327/555 (58%), Gaps = 6/555 (1%)
Query: 50 WKDFHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIE 109
+ D ++ R + G LCD+ L V +K I HK+VLA PYF AMF +EM+E++QT +
Sbjct: 75 YHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVT 134
Query: 110 IRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNC 169
+ D D A++ LV+F Y++ + + NVQ LL AA +LQ+ V ACC+++ PSNC
Sbjct: 135 LHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNC 194
Query: 170 LAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQ 229
L +R FA++H+ DL+ A +Y HF +V + E+F+ + + + +L+SS LN+ +E++
Sbjct: 195 LGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEE 254
Query: 230 VYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEA 289
VY A + W+ + + + + VRLPLL DFL+G V E +V+ + C+DLL EA
Sbjct: 255 VYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEA 314
Query: 290 RNYHLHLSSRAVPDFEYSIRTTPRK-HTAG-VLFCVGGRGGSGDPFRSIECYSINKNSWF 347
+HL R V + RT PR+ AG VLF VGG G E Y + W
Sbjct: 315 LKFHLLPEQRGVLG---TSRTRPRRCEGAGPVLFAVGG-GSLFAIHGDCEAYDTRTDRWH 370
Query: 348 FGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIA 407
M++RR VGV +V ++YAVGG+DG L ++E +DP+TN W + SM T+R +
Sbjct: 371 VVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLG 430
Query: 408 LASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGG 467
+A+L G +Y+ GG D +C N ERYD + W++VA M+T R V L ++YAVGG
Sbjct: 431 VAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGG 490
Query: 468 NDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERY 527
D + L++VE+Y+P ++ W V M RR+ GV+ L G LYV GG D S L+SVERY
Sbjct: 491 YDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERY 550
Query: 528 DPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSV 587
P++ W+ VA + R + + G ++AVGG++G++ LN++E ++P N+W +
Sbjct: 551 SPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCM 610
Query: 588 SHCRAGAGVAVCSCL 602
R+ GVAV L
Sbjct: 611 FTRRSSVGVAVLELL 625
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 397 bits (1021), Expect = e-110
Identities = 214/526 (40%), Positives = 314/526 (59%), Gaps = 16/526 (3%)
Query: 79 SCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQ 138
SC +LVL+ V YF AMF +++ EA+Q I++ + +++ L+++ Y+ RL L DN++
Sbjct: 172 SC-RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIE 230
Query: 139 PLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTE 198
LL AC+LQ+ V ACC+++ HPSNCL +R+FA++ DL +A Y +HF E
Sbjct: 231 CLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFME 290
Query: 199 VVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRL 258
V+ ++FV + + KLL+S D+NI NE+ + NA + W+ + + K L + LA +RL
Sbjct: 291 VIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRL 350
Query: 259 PLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAG 318
PLL FL + + + +++C+ L+ EA YHL R + S RT PRK T G
Sbjct: 351 PLLAPQFLADM-ENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQ---SPRTKPRKSTVG 406
Query: 319 VLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNE 378
LF VGG + SIE Y + N W MN RR GV ++ K+Y VGG DG +
Sbjct: 407 TLFAVGGMDSTKGA-TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 465
Query: 379 HLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESD 438
L ++E ++P T W + M+T R G+ +A L GP+YA+GG D + N VER+D ++
Sbjct: 466 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 525
Query: 439 QWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRA 498
QW+ VA M+TPR VG L +YAVGG DG + L SVE +DPH +KW +M +RR
Sbjct: 526 QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRG 585
Query: 499 GNGVSKLHGCLYVVGGFDDNSPLSS--------VERYDPRSNKWDYVAALTTPRGGVGIA 550
G GV+ +G LY +GG D +P S+ VERYDP+++ W VA+++ R VG+
Sbjct: 586 GVGVTTWNGLLYAIGGHD--APASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVC 643
Query: 551 TVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGV 596
+ K++AVGG++G AYLNTVEA+DP N W V + RAGA V
Sbjct: 644 LLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACV 689
Score = 119 bits (297), Expect = 1e-26
Identities = 60/142 (42%), Positives = 87/142 (61%)
Query: 459 VNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDN 518
V ++AVGG D +S+E+YD + W V M RR GV+ L LYVVGG D
Sbjct: 405 VGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGL 464
Query: 519 SPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVL 578
L++VE Y+P++ W + ++T R G+G+A + G ++AVGGH+G +YLNTVE +DP
Sbjct: 465 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQA 524
Query: 579 NRWELVGSVSHCRAGAGVAVCS 600
+W V ++S R+ GVAV S
Sbjct: 525 RQWNFVATMSTPRSTVGVAVLS 546
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 395 bits (1015), Expect = e-110
Identities = 209/531 (39%), Positives = 313/531 (58%), Gaps = 15/531 (2%)
Query: 60 FYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIE 119
+ + +LCDV L G I H+LVL+ V YF AMF +++ EAKQ + + D +A+
Sbjct: 175 YLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALN 234
Query: 120 DLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESH 179
LV++ Y+ L L D ++ LL AAC+LQ+ V C ++ HPSNCL +R+F ++
Sbjct: 235 SLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQ 294
Query: 180 NRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLL 239
+L+++A +Y +HF EV++ ++F+ + + KLL S D+N+ +E+ +++A ++W+
Sbjct: 295 GCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVG 354
Query: 240 ANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSR 299
+ Q+ L L+ +RLPLLP L + +L+C+ LL EA YHL R
Sbjct: 355 HDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTG-DLECQKLLMEAMKYHLLPERR 413
Query: 300 AVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHV 359
++ S RT PRK T G L+ VGG +IE Y + NSW MN RR
Sbjct: 414 SMMQ---SPRTKPRKSTVGALYAVGGMDAMKGT-TTIEKYDLRTNSWLHIGTMNGRRLQF 469
Query: 360 GVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIG 419
GV ++ K+Y VGG DG + L ++E F+P+ W + M+T R G+ +A+L GP+YA+G
Sbjct: 470 GVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
Query: 420 GLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVER 479
G D + N VER+D E QW+ VA M+TPR VG VAL N +YA+GG DG + L S+E
Sbjct: 530 GHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 589
Query: 480 YDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSS--------VERYDPRS 531
+DPH +KW M +RR G GV+ +G LYVVGG D +P S+ VERYDP+
Sbjct: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHD--APASNHCSRLSDCVERYDPKG 647
Query: 532 NKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWE 582
+ W VA L+ PR V + + K++ VGG++G+ YLNTVE++D N W+
Sbjct: 648 DSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 698
Score = 155 bits (393), Expect = 8e-38
Identities = 80/209 (38%), Positives = 121/209 (57%), Gaps = 4/209 (1%)
Query: 389 LTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNT 448
L + M S TK R S G +YA+GG+D +E+YD+ ++ W + MN
Sbjct: 409 LPERRSMMQSPRTKPR----KSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNG 464
Query: 449 PRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGC 508
R G + N +Y VGG DG+ +L++VE ++P W + M R G GV+ L G
Sbjct: 465 RRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGP 524
Query: 509 LYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYL 568
+Y VGG D S L++VER+DP +W+YVA+++TPR VG+ + K++A+GG +G++ L
Sbjct: 525 MYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCL 584
Query: 569 NTVEAFDPVLNRWELVGSVSHCRAGAGVA 597
++E FDP N+W L +S R G GVA
Sbjct: 585 KSMEYFDPHTNKWSLCAPMSKRRGGVGVA 613
Score = 133 bits (334), Expect = 6e-31
Identities = 71/178 (39%), Positives = 103/178 (57%), Gaps = 7/178 (3%)
Query: 318 GVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGN 377
G ++ VGG G ++E + W + M++ R VGV+++ K+YA+GG DG+
Sbjct: 523 GPMYAVGGHDG-WSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGS 581
Query: 378 EHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLD---DNTCF---NDVE 431
L SME FDP TNKW + A M+ +R G+ +A+ G +Y +GG D N C + VE
Sbjct: 582 SCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVE 641
Query: 432 RYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIE 489
RYD + D WSTVAP++ PR V L + +Y VGG DG L++VE YD ++W E
Sbjct: 642 RYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699
Score = 32.7 bits (73), Expect = 1.0
Identities = 16/48 (33%), Positives = 27/48 (56%)
Query: 551 TVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAV 598
+ +G ++AVGG + T+E +D N W +G+++ R GVAV
Sbjct: 426 STVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAV 473
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 380 bits (976), Expect = e-105
Identities = 204/568 (35%), Positives = 311/568 (54%), Gaps = 7/568 (1%)
Query: 39 EDSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLS 98
ED F +E +G + G+LCDVTLK+G S H++VLA IPYF AMF +
Sbjct: 10 EDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTN 69
Query: 99 EMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCE 158
+M E KQ I ++ D A+E L+ F Y+ L + NVQ LL A LQ++ + ACC
Sbjct: 70 DMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCT 129
Query: 159 YMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLS 218
+++ HP NCL VR FAE+ L D A+ + HF EV E+F+++ + + +L+S
Sbjct: 130 FLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVS 189
Query: 219 SSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQ 278
+LN+++E+QV+ AA+ W+ + + +L E L+ +RLPL FL V ++ +V+
Sbjct: 190 RDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRC 249
Query: 279 NLKCRDLLDEARNYHLHLSSRA-VPDFEYSIRTTPRKHT--AGVLFCVGGRGGSGDPFRS 335
KCRDL+DEA++YHL R +P F RT PR T AG+++ VGG +GD
Sbjct: 250 CHKCRDLVDEAKDYHLMPERRPHLPAF----RTRPRCCTSIAGLIYAVGGLNSAGDSLNV 305
Query: 336 IECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMM 395
+E + N W M + R VGV V G +YA+GG+DG L ++E ++P T+ W
Sbjct: 306 VEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTR 365
Query: 396 KASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGS 455
SMN+KR + L G IY GG D N+ + VE Y E+D+W+ V M++ R G
Sbjct: 366 VGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGV 425
Query: 456 VALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGF 515
+Y GG+DG+ SSVE Y+ H W M +R +G + L ++V GG+
Sbjct: 426 TVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGY 485
Query: 516 DDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFD 575
D + LS E Y +++W + + T R V + G+++AVGG++G + L++VE +D
Sbjct: 486 DGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYD 545
Query: 576 PVLNRWELVGSVSHCRAGAGVAVCSCLT 603
P + W + ++ G GV LT
Sbjct: 546 PETDCWTFMAPMACHEGGVGVGCIPLLT 573
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 379 bits (973), Expect = e-105
Identities = 210/539 (38%), Positives = 318/539 (58%), Gaps = 11/539 (2%)
Query: 66 LCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFV 125
LCDV + I H++VLA PYF AMF +M+E+K IEI+D DG + L+ ++
Sbjct: 49 LCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYI 108
Query: 126 YSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLM 185
Y++ + +T +NVQ LL AA +LQ+ V + CC++++ HP+NCL +RAFA+ H DL+
Sbjct: 109 YTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLL 168
Query: 186 DMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 245
A+ YA HF EV+ E+F+S+S + L+SS L + +E++V+ A I W+ +
Sbjct: 169 QQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETR 228
Query: 246 SKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYH-LHLSSRAVPDF 304
+ + + + VRLPLLP D+L+ V +E ++K N C+D L EA YH L L R +
Sbjct: 229 LEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIK- 287
Query: 305 EYSIRTTPRKHTA--GVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVI 362
+ RT PR + V+ VGG+ RS+ECY ++ W E+ SRR GV+
Sbjct: 288 --NPRTKPRTPVSLPKVMIVVGGQAPKA--IRSVECYDFEEDRWDQIAELPSRRCRAGVV 343
Query: 363 SVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLD 422
+ G VYAVGG +G+ + +++++D + ++W ASM +R + A L +YA+GG D
Sbjct: 344 FMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFD 403
Query: 423 DNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMA--SLSSVERY 480
+T VE Y ++++W VAPMNT R VG + +YAVGG DG + LS+VE+Y
Sbjct: 404 GSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQY 463
Query: 481 DPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAAL 540
+P ++WI V +M RR+G GV L G LY GG D SVE YDP +N W VA +
Sbjct: 464 NPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADM 523
Query: 541 TTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELV-GSVSHCRAGAGVAV 598
R G+ V G ++ VGG +G+ L +VE ++PV ++W L+ ++S R+ AGVAV
Sbjct: 524 NMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAV 582
Score = 166 bits (421), Expect = 5e-41
Identities = 87/238 (36%), Positives = 135/238 (56%), Gaps = 2/238 (0%)
Query: 367 KVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTC 426
KV V G + + S+E +D ++W A + ++R + + G +YA+GG + +
Sbjct: 301 KVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLR 360
Query: 427 FNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDK 486
V+ YD DQW+++A M R +G+ L + +YAVGG DG L+SVE Y ++
Sbjct: 361 VRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNE 420
Query: 487 WIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSP--LSSVERYDPRSNKWDYVAALTTPR 544
W V M RR+ GV + G LY VGG+D S LS+VE+Y+P +N+W YVA ++T R
Sbjct: 421 WFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRR 480
Query: 545 GGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCSCL 602
G G+ + G+++A GGH+G +VE +DP N W+ V ++ CR AGV + L
Sbjct: 481 SGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGL 538
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 375 bits (962), Expect = e-104
Identities = 201/536 (37%), Positives = 315/536 (58%), Gaps = 5/536 (0%)
Query: 66 LCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFV 125
LCDVT+ IS H++VLA PYF AMF EM+E++ + I++ DG + L+ +V
Sbjct: 59 LCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYV 118
Query: 126 YSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLM 185
Y++ + +T +NVQ LL AA +LQ++ V + CCE+++ HP NCL +RAFA+ H DL+
Sbjct: 119 YTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLL 178
Query: 186 DMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 245
+ A+ YA HF +VV E+F+++ + + L+SS L I +E++V+ A I W+ +
Sbjct: 179 NKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVR 238
Query: 246 SKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAVPDFE 305
+++ + VRLPLLP ++L+ V +E +VK + C+D L EA YHL + + +
Sbjct: 239 QEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKS 298
Query: 306 YSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVE 365
R + ++ VGG+ RS+ECY + W E+ SRR G++ +
Sbjct: 299 VRTRLRTPMNLPKLMVVVGGQAPKA--IRSVECYDFKEERWHQVAELPSRRCRAGMVYMA 356
Query: 366 GKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNT 425
G V+AVGG +G+ + +++ +DP+ ++W A+M +R + A L G +YA+GG D +T
Sbjct: 357 GLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGST 416
Query: 426 CFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMA--SLSSVERYDPH 483
+ VE Y+I+S++W VAPMNT R VG + +YAVGG DG + LS+VE Y+
Sbjct: 417 GLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNAT 476
Query: 484 LDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTP 543
++W + EM RR+G GV L+ LY VGG D SVE YDP +N W VA +
Sbjct: 477 TNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMC 536
Query: 544 RGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGS-VSHCRAGAGVAV 598
R G+ V G ++ VGG +G+ L +VE ++P ++W +V S +S R+ AGV V
Sbjct: 537 RRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTV 592
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 375 bits (962), Expect = e-104
Identities = 201/536 (37%), Positives = 315/536 (58%), Gaps = 5/536 (0%)
Query: 66 LCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFV 125
LCDVT+ IS H++VLA PYF AMF EM+E++ + I++ DG + L+ +V
Sbjct: 55 LCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYV 114
Query: 126 YSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLM 185
Y++ + +T +NVQ LL AA +LQ++ V + CCE+++ HP NCL +RAFA+ H DL+
Sbjct: 115 YTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLL 174
Query: 186 DMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 245
+ A+ YA HF +VV E+F+++ + + L+SS L I +E++V+ A I W+ +
Sbjct: 175 NKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVR 234
Query: 246 SKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAVPDFE 305
+++ + VRLPLLP ++L+ V +E +VK + C+D L EA YHL + + +
Sbjct: 235 QEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKS 294
Query: 306 YSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVE 365
R + ++ VGG+ RS+ECY + W E+ SRR G++ +
Sbjct: 295 VRTRLRTPMNLPKLMVVVGGQAPKA--IRSVECYDFKEERWHQVAELPSRRCRAGMVYMA 352
Query: 366 GKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNT 425
G V+AVGG +G+ + +++ +DP+ ++W A+M +R + A L G +YA+GG D +T
Sbjct: 353 GLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGST 412
Query: 426 CFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMA--SLSSVERYDPH 483
+ VE Y+I+S++W VAPMNT R VG + +YAVGG DG + LS+VE Y+
Sbjct: 413 GLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNAT 472
Query: 484 LDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTP 543
++W + EM RR+G GV L+ LY VGG D SVE YDP +N W VA +
Sbjct: 473 TNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMC 532
Query: 544 RGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGS-VSHCRAGAGVAV 598
R G+ V G ++ VGG +G+ L +VE ++P ++W +V S +S R+ AGV V
Sbjct: 533 RRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTV 588
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 352 bits (903), Expect = 6e-97
Identities = 194/552 (35%), Positives = 302/552 (54%), Gaps = 20/552 (3%)
Query: 56 SLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDG 115
+LLR ++ ELCD+ L+VG I HK+VLA V PYF+AMF ++E + + +E + D
Sbjct: 26 NLLR--QHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEVEFQCIDE 83
Query: 116 DAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAF 175
A++ +V++ Y+ + ++ D V+ LL AA +LQ++LV + CC +++ P NC+ + F
Sbjct: 84 TALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCIGISRF 143
Query: 176 AESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAI 235
AE++ DL A +Y C +F V + E+F ++ L +++S+ LN+ E+ V+ A
Sbjct: 144 AETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEETVFYALE 203
Query: 236 KWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLH 295
W+ + Q K+L + L VRLPLL V FL + +++ + C+ LL+EA YH
Sbjct: 204 SWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHF- 262
Query: 296 LSSRAVPDFEYSIRT---TPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEM 352
+P+ S +T T + VL VGG+ G S+E Y +SW +
Sbjct: 263 -----MPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPL 317
Query: 353 NSRRRHVGVISVEGKVYAVGGHDGN--------EHLGSMEMFDPLTNKWMMKASMNTKRR 404
N R G+ ++ KVY +GG N +H S+E ++P TN W MN R
Sbjct: 318 NIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRS 377
Query: 405 GIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYA 464
+ + L G +YA+GG D + VE+Y + +W VAPM T R + L +YA
Sbjct: 378 TLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYA 437
Query: 465 VGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSV 524
+GG G A ++SVERYDP D W V M +R GV + G ++VVGG + S LSS+
Sbjct: 438 IGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSI 496
Query: 525 ERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELV 584
ERYDP N+W + PR GVG A + ++ VGGH+G++YLNTV+ +DP+ + W
Sbjct: 497 ERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDS 556
Query: 585 GSVSHCRAGAGV 596
+ +CR G+
Sbjct: 557 AGMIYCRCNFGL 568
Score = 83.6 bits (205), Expect = 5e-16
Identities = 50/164 (30%), Positives = 82/164 (50%), Gaps = 9/164 (5%)
Query: 464 AVGGNDGM-ASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDN---- 518
AVGG G+ A L SVE Y P D WI + + R G+ L +YV+GG N
Sbjct: 287 AVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPG 346
Query: 519 ----SPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAF 574
+SVE ++P +N W + + R +G+ + G+++A+GG++G +YL +VE +
Sbjct: 347 VTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKY 406
Query: 575 DPVLNRWELVGSVSHCRAGAGVAVCSCLTSQIRDVGHGSNNVVD 618
P + +W+ V ++ R+ AV + I G N V+
Sbjct: 407 IPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAHMNSVE 450
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 340 bits (873), Expect = 2e-93
Identities = 183/502 (36%), Positives = 294/502 (58%), Gaps = 5/502 (0%)
Query: 100 MAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEY 159
M+E++ + I++ DG + L+ +VY++ + +T +NVQ LL AA +LQ++ V + CCE+
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 160 MKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSS 219
++ HP NCL +RAFA+ H DL++ A+ YA HF +VV E+F+++ + + L+SS
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 220 SDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQN 279
L I +E++V+ A I W+ + +++ + VRLPLLP ++L+ V +E +VK +
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
Query: 280 LKCRDLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECY 339
C+D L EA YHL + + + R + ++ VGG+ RS+ECY
Sbjct: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKA--IRSVECY 238
Query: 340 SINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASM 399
+ W E+ SRR G++ + G V+AVGG +G+ + +++ +DP+ ++W A+M
Sbjct: 239 DFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANM 298
Query: 400 NTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALV 459
+R + A L G +YA+GG D +T + VE Y+I+S++W VAPMNT R VG +
Sbjct: 299 RDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 358
Query: 460 NHVYAVGGNDGMA--SLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDD 517
+YAVGG DG + LS+VE Y+ ++W + EM RR+G GV L+ LY VGG D
Sbjct: 359 GLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDG 418
Query: 518 NSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPV 577
SVE YDP +N W VA + R G+ V G ++ VGG +G+ L +VE ++P
Sbjct: 419 PLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPT 478
Query: 578 LNRWELVGS-VSHCRAGAGVAV 598
++W +V S +S R+ AGV V
Sbjct: 479 TDKWTVVSSCMSTGRSYAGVTV 500
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 301 bits (771), Expect = 1e-81
Identities = 182/571 (31%), Positives = 291/571 (50%), Gaps = 20/571 (3%)
Query: 38 GEDSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVG-----SKLISCHKLVLACVIPYF 92
G +F + + K G + + +LCDVTL+V + HK+VLA P F
Sbjct: 48 GNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVF 107
Query: 93 RAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELV 152
+AMF + + E ++ I +E L++F Y++ +++ V ++ A + Q++ V
Sbjct: 108 KAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSV 167
Query: 153 ARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQH 212
RAC +++ PSN + + FAE ++L A +Y HF EV + E+F ++S
Sbjct: 168 VRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQ 227
Query: 213 LHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAK 272
L L+S DLN+ E +V++A I W+ + + ++ L VR L +FL + K
Sbjct: 228 LVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQK 287
Query: 273 EQIVKQNLKCRDLLDEA-RNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGD 331
+I++ + +C+D L + LH ++ +P R G L G G
Sbjct: 288 CEILQSDSRCKDYLVKIFEELTLHKPTQVMPC---------RAPKVGRLIYTAG-GYFRQ 337
Query: 332 PFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGH----DGNEHLGSMEMFD 387
+E Y+ + +W ++ R + V G +YAVGG DGN +++ ++
Sbjct: 338 SLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYN 397
Query: 388 PLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMN 447
P+TN+W A M+ R I + + G IYA+GG N VERY+ E D+W VAPM
Sbjct: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPML 457
Query: 448 TPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHG 507
T R GVG L +YAVGG DG L+S E Y P ++W + M R+G GV LH
Sbjct: 458 TRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHN 517
Query: 508 CLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAY 567
C+Y GG+D L+SVERYD + W +VA + R +GI G+I+ +GG++G+ +
Sbjct: 518 CIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTF 577
Query: 568 LNTVEAFDPVLNRWELVGSVSHCRAGAGVAV 598
L++VE +DP + W V ++ R+G GVAV
Sbjct: 578 LDSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608
Score = 90.1 bits (222), Expect = 5e-18
Identities = 50/145 (34%), Positives = 80/145 (55%), Gaps = 5/145 (3%)
Query: 462 VYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGF----DD 517
+Y GG SLS +E Y+P W+ + ++ R+G + G LY VGG D
Sbjct: 328 IYTAGGYFRQ-SLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 518 NSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPV 577
N+ S+++ Y+P +N+W A ++ PR +G+ + G I+AVGG +G + N+VE ++P
Sbjct: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
Query: 578 LNRWELVGSVSHCRAGAGVAVCSCL 602
+ W LV + R G GVAV + L
Sbjct: 447 RDEWHLVAPMLTRRIGVGVAVLNRL 471
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 301 bits (771), Expect = 1e-81
Identities = 182/571 (31%), Positives = 291/571 (50%), Gaps = 20/571 (3%)
Query: 38 GEDSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVG-----SKLISCHKLVLACVIPYF 92
G +F + + K G + + +LCDVTL+V + HK+VLA P F
Sbjct: 48 GNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVF 107
Query: 93 RAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELV 152
+AMF + + E ++ I +E L++F Y++ +++ V ++ A + Q++ V
Sbjct: 108 KAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSV 167
Query: 153 ARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQH 212
RAC +++ PSN + + FAE ++L A +Y HF EV + E+F ++S
Sbjct: 168 VRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQ 227
Query: 213 LHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAK 272
L L+S DLN+ E +V++A I W+ + + ++ L VR L +FL + K
Sbjct: 228 LVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQK 287
Query: 273 EQIVKQNLKCRDLLDEA-RNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGD 331
+I++ + +C+D L + LH ++ +P R G L G G
Sbjct: 288 CEILQSDSRCKDYLVKIFEELTLHKPTQVMPC---------RAPKVGRLIYTAG-GYFRQ 337
Query: 332 PFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGH----DGNEHLGSMEMFD 387
+E Y+ + +W ++ R + V G +YAVGG DGN +++ ++
Sbjct: 338 SLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYN 397
Query: 388 PLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMN 447
P+TN+W A M+ R I + + G IYA+GG N VERY+ E D+W VAPM
Sbjct: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPML 457
Query: 448 TPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHG 507
T R GVG L +YAVGG DG L+S E Y P ++W + M R+G GV LH
Sbjct: 458 TRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHN 517
Query: 508 CLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAY 567
C+Y GG+D L+SVERYD + W +VA + R +GI G+I+ +GG++G+ +
Sbjct: 518 CIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTF 577
Query: 568 LNTVEAFDPVLNRWELVGSVSHCRAGAGVAV 598
L++VE +DP + W V ++ R+G GVAV
Sbjct: 578 LDSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608
Score = 90.1 bits (222), Expect = 5e-18
Identities = 50/145 (34%), Positives = 80/145 (55%), Gaps = 5/145 (3%)
Query: 462 VYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGF----DD 517
+Y GG SLS +E Y+P W+ + ++ R+G + G LY VGG D
Sbjct: 328 IYTAGGYFRQ-SLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 518 NSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPV 577
N+ S+++ Y+P +N+W A ++ PR +G+ + G I+AVGG +G + N+VE ++P
Sbjct: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
Query: 578 LNRWELVGSVSHCRAGAGVAVCSCL 602
+ W LV + R G GVAV + L
Sbjct: 447 RDEWHLVAPMLTRRIGVGVAVLNRL 471
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 289 bits (740), Expect = 5e-78
Identities = 177/553 (32%), Positives = 281/553 (50%), Gaps = 18/553 (3%)
Query: 63 NGE-LCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDL 121
NG+ CDV L+VG + H+LVLA PYF A+F M E+ + ++ I + + L
Sbjct: 32 NGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQIL 91
Query: 122 VKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNR 181
+ F+Y+ + + V+NVQ L+ AA +LQ+ V CCE++K P NC+ + F+E
Sbjct: 92 LDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIAC 151
Query: 182 IDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLAN 241
DL++ ++ Y HF EV E+F++++ L K+L S +L+IE+E QV+ AA++W+L +
Sbjct: 152 HDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKD 211
Query: 242 PQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAV 301
K + E L +R PLLP L+ + + + LL E
Sbjct: 212 LGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKF 271
Query: 302 PDFEYSIRTTPRKHTAGVLFCVGG----RGGSGDPFRSIEC---YSINKNSWFFGPEMNS 354
F + + PRK L+ VGG +GG R++ C + W ++
Sbjct: 272 CSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQ 331
Query: 355 RRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGP 414
R +GV + G VYA+GG + E +DP+T +W ASMN R G+ + G
Sbjct: 332 ARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGA 391
Query: 415 IYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGG--NDGMA 472
IYA+GG N +ER+D + ++W V M R G + +Y +GG N+G+
Sbjct: 392 IYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGI- 450
Query: 473 SLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDD-NSPLSSVERYDPRS 531
L S E YDP +W + MG RRA GV+ L+ C+Y VGG+++ L +VE+Y
Sbjct: 451 ELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEE 510
Query: 532 NKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGN------AYLNTVEAFDPVLNRWELVG 585
KW VA++ PR G+ + V G ++ GG + + L++VE ++P + W +G
Sbjct: 511 EKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIG 570
Query: 586 SVSHCRAGAGVAV 598
++ R GVAV
Sbjct: 571 NMITSRCEGGVAV 583
Score = 105 bits (262), Expect = 1e-22
Identities = 64/197 (32%), Positives = 103/197 (52%), Gaps = 11/197 (5%)
Query: 318 GVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGG--HD 375
G ++ +GG G+ + +IE + ++N W M R + G ++G +Y +GG ++
Sbjct: 390 GAIYALGGWVGA-EIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNE 448
Query: 376 GNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNT-CFNDVERYD 434
G E L S E++DPL+ +W M T+R + +A+L IY++GG ++ + VE+Y
Sbjct: 449 GIE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYS 507
Query: 435 IESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGM------ASLSSVERYDPHLDKWI 488
E ++W VA M PR G+ VA+ +Y GG +L SVE Y+PH D W
Sbjct: 508 FEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWT 567
Query: 489 EVKEMGQRRAGNGVSKL 505
E+ M R GV+ L
Sbjct: 568 EIGNMITSRCEGGVAVL 584
Score = 76.6 bits (187), Expect = 6e-14
Identities = 37/99 (37%), Positives = 54/99 (54%), Gaps = 8/99 (8%)
Query: 509 LYVVGGF--------DDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVG 560
LY VGG+ D+ LS VER+D S W V++L R G+G+ + G ++A+G
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
Query: 561 GHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVC 599
G + + E +DPV +W V S++H R G GV VC
Sbjct: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVC 388
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 285 bits (728), Expect = 1e-76
Identities = 164/522 (31%), Positives = 265/522 (50%), Gaps = 7/522 (1%)
Query: 64 GELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVK 123
G+LCDV +KV S HK +L YFRA+F S ++ + I D ++ +++
Sbjct: 36 GKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIE 95
Query: 124 FVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRID 183
+ Y+ + +T DNV+ LL AA + + R CCE++K NC+ + F + + +
Sbjct: 96 YAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPE 155
Query: 184 LMDMADQYACDHFTEVVECE-DFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANP 242
L A + +F E+V+ +F+ +S L ++ +LN++ E V+ A +KW+ +P
Sbjct: 156 LRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDP 215
Query: 243 QHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARN--YHLHLSSRA 300
Q+ + + L +VRL L+ ++ M V VK + +C+ ++ A Y L+++ +
Sbjct: 216 QNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPS 275
Query: 301 VPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWF-FGPEMNSRRRHV 359
DF + T PR A +LF +GG G G P +IE Y + W E S R +
Sbjct: 276 NSDFTNPL-TRPRLPYA-ILFAIGGWSG-GSPTNAIEAYDARADRWVNVTCEEESPRAYH 332
Query: 360 GVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIG 419
G ++G VY +GG D ++ S++ FDP+ W A M+++R +++ LG IYA+G
Sbjct: 333 GAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMG 392
Query: 420 GLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVER 479
G D N ERY+ E++QW+ +APM+ R + L VY GG +G L + E
Sbjct: 393 GFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEV 452
Query: 480 YDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAA 539
Y+ ++W + M RR+G GV +Y VGGFD + L S E Y P +N W +
Sbjct: 453 YNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPT 512
Query: 540 LTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRW 581
+ PR GI V +F VGG NG VE +D + W
Sbjct: 513 MFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEW 554
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 275 bits (704), Expect = 7e-74
Identities = 166/514 (32%), Positives = 262/514 (50%), Gaps = 12/514 (2%)
Query: 63 NGE-LCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDL 121
NG+ CDV L+VG + H+LVLA PYF A+F M E+ + ++ I + + L
Sbjct: 32 NGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQIL 91
Query: 122 VKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNR 181
+ F+Y+ + + V+NVQ L+ AA +LQ+ V CCE++K P NC+ + F+E
Sbjct: 92 LDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIAC 151
Query: 182 IDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLAN 241
DL++ ++ Y HF EV E+F++++ L K+L S +L+IE+E QV+ AA++W+L +
Sbjct: 152 HDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKD 211
Query: 242 PQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAV 301
K + E L +R PLLP L+ + + + LL E
Sbjct: 212 LGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKF 271
Query: 302 PDFEYSIRTTPRKHTAGVLFCVGG----RGGSGDPFRSIEC---YSINKNSWFFGPEMNS 354
F + + PRK L+ VGG +GG R++ C + W ++
Sbjct: 272 CSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQ 331
Query: 355 RRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGP 414
R +GV + G VYA+GG + E +DP+T +W ASMN R G+ + G
Sbjct: 332 ARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGA 391
Query: 415 IYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGG--NDGMA 472
IYA+GG N +ER+D + ++W V M R G + +Y +GG N+G+
Sbjct: 392 IYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGI- 450
Query: 473 SLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDD-NSPLSSVERYDPRS 531
L S E YDP +W + MG RRA GV+ L+ C+Y VGG+++ L +VE+Y
Sbjct: 451 ELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEE 510
Query: 532 NKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGN 565
KW VA++ PR G+ + V G ++ GG + +
Sbjct: 511 EKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
Score = 113 bits (283), Expect = 5e-25
Identities = 70/215 (32%), Positives = 101/215 (46%), Gaps = 13/215 (6%)
Query: 415 IYAIGGL--------DDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVG 466
+YA+GG D+ + VER+D S W+TV+ ++ R G+G L VYA+G
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
Query: 467 GNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVER 526
G E YDP +W V M R G GV +G +Y +GG+ +++ER
Sbjct: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
Query: 527 YDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGG-HNGNAYLNTVEAFDPVLNRWELVG 585
+DP NKW+ V + R G + G I+ +GG N L + E +DP+ RW +
Sbjct: 410 FDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLP 469
Query: 586 SVSHCRAGAGVAVCSCLTSQIRDVGHGSNNVVDCM 620
+ RA GVA L I VG G N D +
Sbjct: 470 PMGTRRAYLGVA---ALNDCIYSVG-GWNETQDAL 500
Score = 100 bits (250), Expect = 3e-21
Identities = 59/166 (35%), Positives = 88/166 (53%), Gaps = 11/166 (6%)
Query: 461 HVYAVGGNDGMA--------SLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVV 512
++YAVGG + +LS VER+D W V + Q R+G GV+ L G +Y +
Sbjct: 289 YLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAI 348
Query: 513 GGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVE 572
GG D+ E YDP + +W VA++ PR G+G+ G I+A+GG G NT+E
Sbjct: 349 GGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIE 408
Query: 573 AFDPVLNRWELVGSVSHCRAGAGVAVCSCLTSQIRDVGHGSNNVVD 618
FDP N+WE+VG+++ R G C + I +G SN ++
Sbjct: 409 RFDPDENKWEVVGNMAVSRYYFG---CCEMQGLIYVIGGISNEGIE 451
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 243 bits (619), Expect = 5e-64
Identities = 154/527 (29%), Positives = 249/527 (47%), Gaps = 46/527 (8%)
Query: 53 FHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRD 112
F G + + LCDV L V + I H++VLA +F MF + M E+K +E++D
Sbjct: 30 FMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKD 89
Query: 113 FDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAV 172
+ D IE LV+F Y++R+++ +NVQ LL AA Q+E V + C +++K SNCL +
Sbjct: 90 AEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGI 149
Query: 173 RAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYN 232
AE + +L AD + HFTEV + ++F+ + + + LL+ L + E QVY+
Sbjct: 150 SVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYD 209
Query: 233 AAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNY 292
AA++WL + + ++ + LA+VR PL+ +FL V E +++ N +C ++ Y
Sbjct: 210 AAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRY 269
Query: 293 HLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGR-------------------------- 326
HL LS + R +KH + G +
Sbjct: 270 HL-LSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRD 328
Query: 327 -------------GGSG-DPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVG 372
GGS P + ++CY++ K+SW+ + R + + EGK+Y G
Sbjct: 329 AACVFWDNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSG 388
Query: 373 GHD-GNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNT----CF 427
G + GN L E +D T W K SM T+R + G IY GG N
Sbjct: 389 GSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVL 448
Query: 428 NDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKW 487
N E YD ++ W+ + PM R G V + + ++AVGG +G+ L +VE YD L++W
Sbjct: 449 NSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEW 508
Query: 488 IEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKW 534
V M + + + +YV+ GF L + Y+ ++KW
Sbjct: 509 KMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555
Score = 91.7 bits (226), Expect = 2e-18
Identities = 56/187 (29%), Positives = 83/187 (44%), Gaps = 9/187 (4%)
Query: 311 TPRKHTA-----GVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVE 365
TPR A G ++ GG ECY SW P M ++R G++
Sbjct: 370 TPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEAN 429
Query: 366 GKVYAVGGHDGNEHLG----SMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGL 421
G +Y GG GN G S E++DP T W M R+ L + I+A+GG
Sbjct: 430 GLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQ 489
Query: 422 DDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYD 481
+ ++VE YDI+ ++W V+PM V A+ + VY + G G+ L + Y+
Sbjct: 490 NGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYN 549
Query: 482 PHLDKWI 488
DKW+
Sbjct: 550 TETDKWV 556
Score = 52.8 bits (125), Expect = 1e-06
Identities = 48/188 (25%), Positives = 70/188 (37%), Gaps = 12/188 (6%)
Query: 415 IYAIGGLDDNTCFNDVERYDIESD-QWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMAS 473
I GG +C RY D W+ + R V N VY +GG+ +
Sbjct: 295 IALFGGSQPQSC-----RYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFP 348
Query: 474 LSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFD-DNSPLSSVERYDPRSN 532
+ ++ Y+ D W R G +Y GG + NS L E YD R+
Sbjct: 349 IKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTE 408
Query: 533 KWDYVAALTTPRGGVGIATVMGKIFAVGGHNGN----AYLNTVEAFDPVLNRWELVGSVS 588
W ++ T R G+ G I+ GG GN LN+ E +DP W + +
Sbjct: 409 SWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMI 468
Query: 589 HCRAGAGV 596
R G+
Sbjct: 469 EARKNHGL 476
Score = 38.5 bits (88), Expect = 0.019
Identities = 27/91 (29%), Positives = 41/91 (45%), Gaps = 5/91 (5%)
Query: 320 LFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEH 379
+F VGG+ G G ++E Y I N W M + V +V VY + G G
Sbjct: 483 IFAVGGQNGLGG-LDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGR 541
Query: 380 LGSMEMFDPLTNKWMMKASMNTKRRGIALAS 410
LG + ++ T+KW+ N+K R + S
Sbjct: 542 LGHILEYNTETDKWV----ANSKVRAFPVTS 568
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 241 bits (616), Expect = 1e-63
Identities = 152/514 (29%), Positives = 245/514 (47%), Gaps = 46/514 (8%)
Query: 66 LCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFV 125
LCDV L V + I H++VLA +F MF + M E+K +E++D + D IE LV+F
Sbjct: 21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFA 80
Query: 126 YSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLM 185
Y++R+++ +NVQ LL AA Q+E V + C +++K SNCL + AE + +L
Sbjct: 81 YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELK 140
Query: 186 DMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 245
AD + HFTEV + ++F+ + + + LL+ L + E QVY+AA++WL + +
Sbjct: 141 ATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNR 200
Query: 246 SKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAVPDFE 305
++ + LA+VR PL+ +FL V E +++ N +C ++ YHL LS +
Sbjct: 201 QPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHL-LSPEDREELV 259
Query: 306 YSIRTTPRKHTAGVLFCVGGR--------------------------------------- 326
R +KH + G +
Sbjct: 260 DGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYIL 319
Query: 327 GGSG-DPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHD-GNEHLGSME 384
GGS P + ++CY++ K+SW+ + R + + EGK+Y GG + GN L E
Sbjct: 320 GGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFE 379
Query: 385 MFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNT----CFNDVERYDIESDQW 440
+D T W K SM T+R + G IY GG N N E YD ++ W
Sbjct: 380 CYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETW 439
Query: 441 STVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGN 500
+ + PM R G V + + ++AVGG +G+ L +VE YD L++W V M +
Sbjct: 440 TELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTV 499
Query: 501 GVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKW 534
+ + +YV+ GF L + Y+ ++KW
Sbjct: 500 KCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 533
Score = 91.7 bits (226), Expect = 2e-18
Identities = 56/187 (29%), Positives = 83/187 (44%), Gaps = 9/187 (4%)
Query: 311 TPRKHTA-----GVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVE 365
TPR A G ++ GG ECY SW P M ++R G++
Sbjct: 348 TPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEAN 407
Query: 366 GKVYAVGGHDGNEHLG----SMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGL 421
G +Y GG GN G S E++DP T W M R+ L + I+A+GG
Sbjct: 408 GLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQ 467
Query: 422 DDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYD 481
+ ++VE YDI+ ++W V+PM V A+ + VY + G G+ L + Y+
Sbjct: 468 NGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYN 527
Query: 482 PHLDKWI 488
DKW+
Sbjct: 528 TETDKWV 534
Score = 52.8 bits (125), Expect = 1e-06
Identities = 48/188 (25%), Positives = 70/188 (37%), Gaps = 12/188 (6%)
Query: 415 IYAIGGLDDNTCFNDVERYDIESD-QWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMAS 473
I GG +C RY D W+ + R V N VY +GG+ +
Sbjct: 273 IALFGGSQPQSC-----RYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFP 326
Query: 474 LSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFD-DNSPLSSVERYDPRSN 532
+ ++ Y+ D W R G +Y GG + NS L E YD R+
Sbjct: 327 IKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTE 386
Query: 533 KWDYVAALTTPRGGVGIATVMGKIFAVGGHNGN----AYLNTVEAFDPVLNRWELVGSVS 588
W ++ T R G+ G I+ GG GN LN+ E +DP W + +
Sbjct: 387 SWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMI 446
Query: 589 HCRAGAGV 596
R G+
Sbjct: 447 EARKNHGL 454
Score = 38.5 bits (88), Expect = 0.019
Identities = 27/91 (29%), Positives = 41/91 (45%), Gaps = 5/91 (5%)
Query: 320 LFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEH 379
+F VGG+ G G ++E Y I N W M + V +V VY + G G
Sbjct: 461 IFAVGGQNGLGG-LDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGR 519
Query: 380 LGSMEMFDPLTNKWMMKASMNTKRRGIALAS 410
LG + ++ T+KW+ N+K R + S
Sbjct: 520 LGHILEYNTETDKWV----ANSKVRAFPVTS 546
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 232 bits (591), Expect = 9e-61
Identities = 156/546 (28%), Positives = 263/546 (48%), Gaps = 67/546 (12%)
Query: 60 FYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIE 119
F ++ DV + V K CH+ VL+ YFRAMF ++ E+++ L+EI +A+E
Sbjct: 59 FRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAME 118
Query: 120 DLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESH 179
+++VY+ ++ +T +NVQ L + + Q+ ++ AC ++++ P NCL ++ FA++H
Sbjct: 119 CFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTH 178
Query: 180 NRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLL 239
+ L +A F +V + E+F+ + L + S +L I E+ V+ A ++W+
Sbjct: 179 SLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVY 238
Query: 240 ANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSR 299
L E L VRLPLL ++ + V +Q+++ + +C LL EAR YH+ +
Sbjct: 239 RAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEM 298
Query: 300 AVPDFEYSIRTTPRKHT--AGVLFCVGG---RGGSGDPFRSIECYS-------------- 340
P RT PR+ T + V+ VGG GG P+ ECY
Sbjct: 299 MSP------RTRPRRSTGYSEVIVVVGGCERVGGFNLPY--TECYDPVTGEWKSLAKLPE 350
Query: 341 ---------------------IN-KNSWFFGPEMN----------SRRRHVGVISVEGKV 368
IN ++ W + ++N R RH + + GKV
Sbjct: 351 FTKSEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLL-GKV 409
Query: 369 YAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAI-GGLDDNTCF 427
Y VGG+DG L S+E +D +N+W A + A+ S G ++ I GG DDNTC
Sbjct: 410 YVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCS 469
Query: 428 NDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKW 487
+ V+ YD E++ W A + + + +V+L N +Y GG ++ YDP D W
Sbjct: 470 DKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG-----LTKAIYCYDPVEDYW 524
Query: 488 IEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLS-SVERYDPRSNKWDYVAALTTPRGG 546
+ V+ R+ G+S +G +Y++GG +N + ++ YDP ++ VAA+ P
Sbjct: 525 MHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSY 584
Query: 547 VGIATV 552
G T+
Sbjct: 585 HGCVTI 590
Score = 81.3 bits (199), Expect = 2e-15
Identities = 55/177 (31%), Positives = 88/177 (49%), Gaps = 7/177 (3%)
Query: 415 IYAIGGLDDNTCFN--DVERYDIESDQWSTVAPM-NTPRGGVGSVALVNHVYAVGGNDGM 471
I +GG + FN E YD + +W ++A + + AL N + GG
Sbjct: 315 IVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGR--- 371
Query: 472 ASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRS 531
+ V Y+ L+ WI V + + R + ++ L G +YVVGG+D + LSSVE YD S
Sbjct: 372 INSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFS 431
Query: 532 NKWDYVAALTTPRGGVGIATVMGKIFAVGGH-NGNAYLNTVEAFDPVLNRWELVGSV 587
N+W VA L + + +GK+F +GG + N + V+++DP N W L ++
Sbjct: 432 NRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAI 488
Score = 60.5 bits (145), Expect = 5e-09
Identities = 47/175 (26%), Positives = 82/175 (46%), Gaps = 11/175 (6%)
Query: 428 NDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGND--GMASLSSVERYDPHLD 485
++ RY I ++ ++P PR G ++ VGG + G +L E YDP
Sbjct: 286 HEARRYHILGNEM--MSPRTRPRRSTGYSEVI---VVVGGCERVGGFNLPYTECYDPVTG 340
Query: 486 KWIEVKEMGQ-RRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPR 544
+W + ++ + ++ V L + V GG ++ V Y+ + N W VA+L R
Sbjct: 341 EWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSR---DVWIYNSQLNIWIRVASLNKGR 397
Query: 545 GGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVC 599
+A ++GK++ VGG++G L++VE +D NRW V + + V C
Sbjct: 398 WRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSC 452
>gi|24475847 influenza virus NS1A binding protein [Homo sapiens]
Length = 642
Score = 218 bits (555), Expect = 1e-56
Identities = 156/580 (26%), Positives = 265/580 (45%), Gaps = 48/580 (8%)
Query: 62 ENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDL 121
++G+ CDV L+V + H+ VLAC PY +F S+ + ++ D + +A+E L
Sbjct: 27 KSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVL 86
Query: 122 VKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNR 181
+ + Y+++L + V+ + AA L+++ V + C +Y+ ++C++ R FA
Sbjct: 87 LNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFASCMGD 146
Query: 182 IDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLAN 241
L++ D Y +H ++ E E+F+ + L +L + N K +Y I W+ +
Sbjct: 147 SRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVCLPSNGK-LYTKVINWVQRS 205
Query: 242 PQHHSKWLDETLAQVRL-------PLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHL 294
+ L+E + +V+ LL + L G +++ N H
Sbjct: 206 IWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHK 265
Query: 295 HLSSRAV------------PDFEYSIRTTPRKHTAGVL--------FCVGGRGGSGDPFR 334
+SS + P E+ I + + L FCV G P
Sbjct: 266 QISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVIFLHGRNSPQS 325
Query: 335 SIECYSINKNSWFFGPE-----------MNSRRRHVGVISVEGKVYAVGGHDGNEHLGSM 383
S S F + M R +G + GK+ A GG++ E L ++
Sbjct: 326 SPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTV 385
Query: 384 EMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGL----DDNTCFNDVERYDIESDQ 439
E ++P T+ W A M T R +A L G +Y +GG DD +C E YD D
Sbjct: 386 ECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCG---EMYDSNIDD 442
Query: 440 WSTVAPMNTPRGGVGSVALVNHVYAVGGND--GMASLSSVERYDPHLDKWIEVKEMGQRR 497
W V + T R G AL +Y VGG+D G L + + +DP W + RR
Sbjct: 443 WIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRR 502
Query: 498 AGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIF 557
+ V +L G LY++GG + + L++VERY+P +N W +A + R G G+A + GK+F
Sbjct: 503 HQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLF 562
Query: 558 AVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVA 597
GG +G+ ++ VE +DP N W+++G+++ R+ AG+A
Sbjct: 563 VCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIA 602
Score = 168 bits (426), Expect = 1e-41
Identities = 91/267 (34%), Positives = 143/267 (53%), Gaps = 4/267 (1%)
Query: 318 GVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGN 377
G L GG + R++ECY+ + + W F M + R + + G++Y VGG +G+
Sbjct: 368 GKLIAAGGYNRE-ECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGH 426
Query: 378 -EHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDD--NTCFNDVERYD 434
+ L EM+D + W+ + T R + +L G +Y +GG D + + +D
Sbjct: 427 SDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFD 486
Query: 435 IESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMG 494
+ W++ AP+N R L ++Y +GG + L++VERY+P + W + M
Sbjct: 487 PVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMN 546
Query: 495 QRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMG 554
R G GV+ L+G L+V GGFD + +S VE YDP N+W + +T+PR GIATV
Sbjct: 547 VARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGN 606
Query: 555 KIFAVGGHNGNAYLNTVEAFDPVLNRW 581
I+AVGG +GN +LNTVE ++ N W
Sbjct: 607 TIYAVGGFDGNEFLNTVEVYNLESNEW 633
Score = 100 bits (248), Expect = 5e-21
Identities = 47/124 (37%), Positives = 72/124 (58%), Gaps = 1/124 (0%)
Query: 318 GVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGN 377
G L+ +GG S + ++E Y+ N+W MN RR GV + GK++ GG DG+
Sbjct: 512 GYLYIIGG-AESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGS 570
Query: 378 EHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIES 437
+ +EM+DP N+W M +M + R +A++G IYA+GG D N N VE Y++ES
Sbjct: 571 HAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLES 630
Query: 438 DQWS 441
++WS
Sbjct: 631 NEWS 634
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 209 bits (533), Expect = 5e-54
Identities = 155/562 (27%), Positives = 257/562 (45%), Gaps = 56/562 (9%)
Query: 36 GDGEDSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVGSKLI-SCHKLVLACVIPYFRA 94
G + ++F+ + DF + FY +G D+TL+ S +I CH+ VLA YF+A
Sbjct: 5 GQEDYIYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKA 64
Query: 95 MFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVAR 154
MF ++M E + I++ D +E LV + Y+S++ +T NVQ LL AA +LQ V +
Sbjct: 65 MFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKK 124
Query: 155 ACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLH 214
AC ++ H NC+ + +FAE H +L + + C F EV + E+F+ +S +
Sbjct: 125 ACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFL 184
Query: 215 KLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQ 274
+LS +L++ E+ + IKW + ++ + L L+ + + + PV + +
Sbjct: 185 FILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDIDPVYLKTALGLQRS 244
Query: 275 IVKQNLKCRDLLDEARN-YHLHLSSRA--------------------------------- 300
+ K R L+ A N H +S R+
Sbjct: 245 CLLTENKIRSLIYNALNPMHKEISQRSTATMYIIGGYYWHPLSEVHIWDPLTNVWIQGAE 304
Query: 301 VPDF---EYSIRTT-PRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFG-PEMNSR 355
+PD+ Y + P + G G R + + ++ Y+ + W G P +N+R
Sbjct: 305 IPDYTRESYGVTCLGPNIYVTG-----GYRTDNIEALDTVWIYNSESDEWTEGLPMLNAR 359
Query: 356 RRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPI 415
H V ++ G VYA+GG+ E +DPL KW+ A+M L I
Sbjct: 360 YYHCAV-TLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVI 418
Query: 416 YAIG---GLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMA 472
Y IG G + ++ V+ Y+ + ++WS + P G+ SV N +Y VGG
Sbjct: 419 YVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGG----- 473
Query: 473 SLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGG--FDDNSPLSSVERYDPR 530
+ E YDP ++W E+ M +RR G ++GC+YV GG + + L S+E+YDP
Sbjct: 474 QTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPD 533
Query: 531 SNKWDYVAALTTPRGGVGIATV 552
NKW+ V L + G V
Sbjct: 534 LNKWEIVGNLPSAMRSHGCVCV 555
Score = 50.4 bits (119), Expect = 5e-06
Identities = 39/148 (26%), Positives = 62/148 (41%), Gaps = 13/148 (8%)
Query: 319 VLFCVGGRGG--SGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISV--EGKVYAVGGH 374
V++ +GG G + ++ Y+ + N W +S G+ SV E K+Y VGG
Sbjct: 417 VIYVIGGHCGYRGSCTYDKVQSYNSDINEWSL--ITSSPHPEYGLCSVPFENKLYLVGGQ 474
Query: 375 DGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLD--DNTCFNDVER 432
E +DP N+W A M +R + G IY GG T +E+
Sbjct: 475 TT-----ITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEK 529
Query: 433 YDIESDQWSTVAPMNTPRGGVGSVALVN 460
YD + ++W V + + G V + N
Sbjct: 530 YDPDLNKWEIVGNLPSAMRSHGCVCVYN 557
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 209 bits (531), Expect = 8e-54
Identities = 158/574 (27%), Positives = 256/574 (44%), Gaps = 27/574 (4%)
Query: 50 WKDFHGSLLRFYEN----GELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQ 105
W D ++L+ G CDV L + + H+ +LA YF +MF M EA Q
Sbjct: 25 WADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQ 84
Query: 106 TLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFH 165
+E+ ++ +V F+Y L L N+ +L A +LQ+ V CCEY++
Sbjct: 85 KEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVS 144
Query: 166 PSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFV-SVSPQHLHKLLSSSDLNI 224
N L ++ A ++ L D + +HF + DF+ +VS Q L LSSS++
Sbjct: 145 EDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQR 204
Query: 225 ENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVV--AKEQIVKQNLKC 282
E E + AA++WL P+ + + L + PL+P + L+ V A ++ + C
Sbjct: 205 ECEHDLLQAALQWLTQQPEREAH-ARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANC 263
Query: 283 RDLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECY-SI 341
++EA YH +L+++ V + RT R + +LF G CY
Sbjct: 264 EGFIEEAVRYHNNLAAQPVMQTK---RTALRTNQERLLFVGGEVSERCLELSDDTCYLDA 320
Query: 342 NKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGS-----MEMFDPLTNKWMMK 396
W + +RR H V + G ++ GG ++ G + +DP +W+
Sbjct: 321 KSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKV 380
Query: 397 ASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSV 456
ASMN +R LAS+ + AIGG ++N + VE Y ++D WS VA + G
Sbjct: 381 ASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGT 440
Query: 457 ALVNHVYAVGGNDGMAS--LSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGG 514
+ VY GG+D ++ YD D W E + M R + + L +Y +GG
Sbjct: 441 IYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGG 500
Query: 515 FDDN------SPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHN--GNA 566
DDN + VE Y P+ N+W VA L G+A G+I+ +GG++ A
Sbjct: 501 SDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTA 560
Query: 567 YLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCS 600
+ TV+ +D ++W + AG VC+
Sbjct: 561 FSKTVQVYDREADKWSRGVDLPKAIAGGSACVCA 594
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 208 bits (530), Expect = 1e-53
Identities = 143/526 (27%), Positives = 245/526 (46%), Gaps = 25/526 (4%)
Query: 68 DVTLKV-GSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVY 126
DVTL+ G + H+ VLA PYFRAMF ++ E++ + + D ++ L+ F Y
Sbjct: 36 DVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSY 95
Query: 127 SSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMD 186
+ R+ ++ DN +PLL AA +LQ V AC +++ +NCL ++ FAE+ + L
Sbjct: 96 TGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLAS 155
Query: 187 MADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHS 246
A ++ H E + E + L + L L + E+ Y A++W+ A+P +
Sbjct: 156 AAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRA 214
Query: 247 KWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAVPDFEY 306
+ L VRLP + +L+ V E +V + C LL EAR++ R
Sbjct: 215 AHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCP 274
Query: 307 SIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVG----VI 362
+R P A +L VGG D +++CY+ W + E H+G ++
Sbjct: 275 RMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPD---HLGGGYSIV 331
Query: 363 SVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLD 422
++ +Y GG DG+ + ++ N+W A M R + + L G +Y +
Sbjct: 332 ALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAA-- 389
Query: 423 DNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDP 482
+ ERYD +D W + PM P + A +YA+G G ++ ++ YDP
Sbjct: 390 -----DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETM-VMQCYDP 443
Query: 483 HLDKW--IEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAAL 540
D W ++ ++ + L+G +Y V DD+ + V+ Y+P N+WD + ++
Sbjct: 444 DTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVR--DDS---AEVDVYNPTRNEWDKIPSM 498
Query: 541 TTPRGGVGIATVMGKIFAVGGHNGNAYL-NTVEAFDPVLNRWELVG 585
G +A + GK++ GG++ L + VEA+DP W +VG
Sbjct: 499 NQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVG 544
Score = 72.0 bits (175), Expect = 2e-12
Identities = 59/226 (26%), Positives = 90/226 (39%), Gaps = 52/226 (23%)
Query: 418 IGGLD-DNTCFNDVERYDIESDQWSTVAPMNTPRGGVGS-VALVNHVYAVGGNDGMASLS 475
+GG D D V+ Y+ ++ QW +A GG S VAL N +Y GG+DG
Sbjct: 291 VGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYD 350
Query: 476 SVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWD 535
V RY+ +++W EV M + R + S L G LYVV S ERYD ++ W+
Sbjct: 351 CVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAA-------DSTERYDHTTDSWE 403
Query: 536 YVAALTTPRGGVGIATVMGKIFAVGGHNGN------------------------------ 565
+ +T P G+++A+G G
Sbjct: 404 ALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAP 463
Query: 566 --AYLN-----------TVEAFDPVLNRWELVGSVSHCRAGAGVAV 598
A LN V+ ++P N W+ + S++ G +AV
Sbjct: 464 KTATLNGLMYFVRDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAV 509
Score = 52.0 bits (123), Expect = 2e-06
Identities = 35/114 (30%), Positives = 54/114 (47%), Gaps = 15/114 (13%)
Query: 346 WFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRG 405
W F P+ ++ G +Y V + +++++P N+W SMN G
Sbjct: 459 WSFAPK---------TATLNGLMYFV-----RDDSAEVDVYNPTRNEWDKIPSMNQVHVG 504
Query: 406 IALASLGGPIYAIGGLDDNTCFNDV-ERYDIESDQWSTVAPMNTPRGGVGSVAL 458
+LA LGG +Y GG D+ +DV E YD E+ WS V + P GSV++
Sbjct: 505 GSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSI 558
Score = 42.0 bits (97), Expect = 0.002
Identities = 27/97 (27%), Positives = 48/97 (49%), Gaps = 5/97 (5%)
Query: 497 RAGNGVSKLHGCLYVVGGFD-DNSPLSSVERYDPRSNKWDYVAALTTPRGG-VGIATVMG 554
R G++++ L +VGG D D L +V+ Y+P++ +W Y+A GG I +
Sbjct: 279 RPSTGLAEI---LVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGN 335
Query: 555 KIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCR 591
I+ GG +G+ + V ++ +N W V + R
Sbjct: 336 DIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAR 372
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 207 bits (526), Expect = 3e-53
Identities = 146/526 (27%), Positives = 240/526 (45%), Gaps = 30/526 (5%)
Query: 66 LCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFV 125
L DV L V + SCH++VLA YFRAMF +++ E + I I+ D + + L+ +
Sbjct: 71 LTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYT 130
Query: 126 YSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLM 185
Y+S+ +T NVQ +L AA + Q + AC ++ +P NC+ + A++H+ L
Sbjct: 131 YTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLK 190
Query: 186 DMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 245
Y +F +++ E+F+ + LH +L S DL + E QV+ + W+ P
Sbjct: 191 KQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSER 250
Query: 246 SKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAVPDFE 305
L L VRLPLL + + V + +++Q + LL EAR Y HLS +
Sbjct: 251 LCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMY--HLSGNEI---- 304
Query: 306 YSIRTTPRKH--TAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEM----------N 353
S RT PR H + V +GG + C + S ++ N
Sbjct: 305 ISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESEN 364
Query: 354 SRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGG 413
+ ++++ +VY GG + +H + ++ NKW+ +N R + LGG
Sbjct: 365 KKWVEFACVTLKNEVYISGGKE-TQH--DVWKYNSSINKWIQIEYLNIGRWRHKMVVLGG 421
Query: 414 PIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGN-DGMA 472
+Y IGG D N+VE YD + WS AP+ + + +Y +GG +G
Sbjct: 422 KVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKL 481
Query: 473 SLSSVERYDPHLDKW-IEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRS 531
+ + YDP +KW ++ + + N VS +YVVGG + ++ Y P
Sbjct: 482 ATDKTQCYDPSTNKWSLKAAMPVEAKCINAVS-FRDRIYVVGG-----AMRALYAYSPLE 535
Query: 532 NKWDYVAALTTPRGGVGIATVMGKIFAVGGHN-GNAYLNTVEAFDP 576
+ W V L+ R GIA +++ GG + N + TV +DP
Sbjct: 536 DSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDP 581
Score = 43.1 bits (100), Expect = 8e-04
Identities = 22/73 (30%), Positives = 36/73 (49%), Gaps = 3/73 (4%)
Query: 509 LYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYL 568
+Y+ GG + V +Y+ NKW + L R + + GK++ +GG +G +
Sbjct: 379 VYISGGKETQH---DVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRI 435
Query: 569 NTVEAFDPVLNRW 581
N VE +DP N W
Sbjct: 436 NNVETYDPFHNCW 448
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 205 bits (522), Expect = 9e-53
Identities = 149/540 (27%), Positives = 253/540 (46%), Gaps = 31/540 (5%)
Query: 68 DVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRD-FDGDAIEDLVKFVY 126
DVTL G + CH+ VLA YF AMF + E++ + +D + +E L+ F Y
Sbjct: 47 DVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAY 106
Query: 127 SSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMD 186
SSR+ + +N + LL A +LQ V A E+++ + PSNCL + +++H L +
Sbjct: 107 SSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYE 166
Query: 187 MADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHS 246
+ + HF V + EDF S+S L L+SS +L E+E+ V+ A ++W+ + +
Sbjct: 167 FSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRK 226
Query: 247 KWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAVPDFEY 306
L E L VRL LLP D L V+ E ++ + + + ++DEA L +R + +
Sbjct: 227 VHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEA----LRCKTRILQNDGV 282
Query: 307 SIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGP--EMNSRRRHVGVISV 364
R AG + G G F + Y ++ + P ++ S R+ ++
Sbjct: 283 VTSPCARPRKAGHTLLILG----GQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAI 338
Query: 365 EGKVYAVGGHDGNEHLGSME--MFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGG-- 420
KVY GG G+E+ S + ++D + +W A M R G A L +Y +GG
Sbjct: 339 GCKVYVTGGR-GSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHT 397
Query: 421 -------LDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVN---HVYAVGGND- 469
+ VE+YD +++W VAP+ R GV + A+V+ ++ GG
Sbjct: 398 SLAGVFPASPSVSLKQVEKYDPGANKWMMVAPL---RDGVSNAAVVSAKLKLFVFGGTSI 454
Query: 470 GMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDP 529
+S V+ YDP ++W E Q + L ++++GG D +S R+D
Sbjct: 455 HRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFTAASAYRFDC 513
Query: 530 RSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSH 589
+N+W + +T R K++ VGG+ G T++ +DP + W + +V +
Sbjct: 514 ETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPY 573
Score = 42.0 bits (97), Expect = 0.002
Identities = 31/101 (30%), Positives = 43/101 (42%), Gaps = 11/101 (10%)
Query: 507 GC-LYVVGGF-DDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNG 564
GC +YV GG +N V YD +W A + R G G A + ++ VGGH
Sbjct: 339 GCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTS 398
Query: 565 NA---------YLNTVEAFDPVLNRWELVGSVSHCRAGAGV 596
A L VE +DP N+W +V + + A V
Sbjct: 399 LAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAV 439
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,634,988
Number of Sequences: 37866
Number of extensions: 1057610
Number of successful extensions: 3433
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 151
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 2139
Number of HSP's gapped (non-prelim): 423
length of query: 620
length of database: 18,247,518
effective HSP length: 108
effective length of query: 512
effective length of database: 14,157,990
effective search space: 7248890880
effective search space used: 7248890880
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.