Search of human proteins with 31982936

Search of human proteins with 31982936

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31982936 sphingosine-1-phosphate lyase 1 [Homo sapiens]
         (568 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31982936 sphingosine-1-phosphate lyase 1 [Homo sapiens]           1151   0.0  
gi|197383062 glutamate decarboxylase-like 1 [Homo sapiens]             42   0.002
gi|197276620 glutamate decarboxylase 2 [Homo sapiens]                  40   0.004
gi|4503875 glutamate decarboxylase 2 [Homo sapiens]                    40   0.004
gi|58331246 glutamate decarboxylase 1 isoform GAD67 [Homo sapiens]     37   0.049
gi|4557289 alanine-glyoxylate aminotransferase [Homo sapiens]          35   0.18 
gi|194294551 cysteine sulfinic acid decarboxylase [Homo sapiens]       34   0.31 
gi|108773801 glycine dehydrogenase (decarboxylating) [Homo sapiens]    32   1.2  
gi|132814448 dopa decarboxylase (aromatic L-amino acid decarboxy...    30   5.9  
gi|4503281 dopa decarboxylase (aromatic L-amino acid decarboxyla...    30   5.9  

>gi|31982936 sphingosine-1-phosphate lyase 1 [Homo sapiens]
          Length = 568

 Score = 1151 bits (2977), Expect = 0.0
 Identities = 568/568 (100%), Positives = 568/568 (100%)

Query: 1   MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFV 60
           MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFV
Sbjct: 1   MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFV 60

Query: 61  FQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQG 120
           FQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQG
Sbjct: 61  FQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQG 120

Query: 121 LSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPG 180
           LSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPG
Sbjct: 121 LSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPG 180

Query: 181 LRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQS 240
           LRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQS
Sbjct: 181 LRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQS 240

Query: 241 AHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPE 300
           AHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPE
Sbjct: 241 AHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPE 300

Query: 301 VAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKG 360
           VAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKG
Sbjct: 301 VAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKG 360

Query: 361 SSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEAT 420
           SSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEAT
Sbjct: 361 SSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEAT 420

Query: 421 KQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFP 480
           KQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFP
Sbjct: 421 KQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFP 480

Query: 481 PSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAE 540
           PSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAE
Sbjct: 481 PSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAE 540

Query: 541 LSSVFLDSLYSTDTVTQGSQMNGSPKPH 568
           LSSVFLDSLYSTDTVTQGSQMNGSPKPH
Sbjct: 541 LSSVFLDSLYSTDTVTQGSQMNGSPKPH 568


>gi|197383062 glutamate decarboxylase-like 1 [Homo sapiens]
          Length = 521

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 68/286 (23%), Positives = 110/286 (38%), Gaps = 41/286 (14%)

Query: 196 FNGGPDSCGCVTSGGTESILMACKAYR-----DLAFEKGIK-TPEIVAPQSA--HAAFNK 247
           F G  +  G    GG+ S + A    R     D+  EKG+  +P ++   SA  H +  K
Sbjct: 166 FIGWKEGDGIFNPGGSVSNMYAMNLARYKYCPDIK-EKGLSGSPRLILFTSAECHYSMKK 224

Query: 248 AASYFGMKIVRVPLT------KMM--EVDVRAMRRAISRNTAMLVCSTPQFPH-GVIDPV 298
           AAS+ G+    V         KM+  E++ +  +         LVC+T      G  DP+
Sbjct: 225 AASFLGIGTENVCFVETDGRGKMIPEELEKQVWQARKEGAAPFLVCATSGTTVLGAFDPL 284

Query: 299 PEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAP 358
            E+A +  ++ + LHVDA  GG  +  M +    L H     +    S++ + HK   A 
Sbjct: 285 DEIADICERHSLWLHVDASWGGSAL--MSRKHRKLLH----GIHRADSVAWNPHKMLMAG 338

Query: 359 KGSSLVLYSDKK---------YRNYQF----FVDTDWQGGIYASPTIAGSRPGGISAACW 405
                +L  DK            +Y F    F D  +  G          RP       W
Sbjct: 339 IQCCALLVKDKSDLLKKCYSAKASYLFQQDKFYDVSYDTG--DKSIQCSRRPDAFK--FW 394

Query: 406 AALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVI 451
                 G  G  E   + +  +R+L  E++  +G  +   P+ + I
Sbjct: 395 MTWKALGTLGLEERVNRALALSRYLVDEIKKREGFKLLMEPEYANI 440


>gi|197276620 glutamate decarboxylase 2 [Homo sapiens]
          Length = 585

 Score = 40.4 bits (93), Expect = 0.004
 Identities = 43/142 (30%), Positives = 62/142 (43%), Gaps = 16/142 (11%)

Query: 199 GPDSCGCVTSGGTESILMACKAYRDLAF----EKGIKT-PEIVAPQSAHAAFN--KAASY 251
           G    G  + GG  S + A    R   F    EKG+   P ++A  S H+ F+  K A+ 
Sbjct: 232 GGSGDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAA 291

Query: 252 FGMKIVRVPLTKMME--------VDVRAMRRAISRNTAMLVCSTPQFP-HGVIDPVPEVA 302
            G+    V L K  E        ++ R +          LV +T     +G  DP+  VA
Sbjct: 292 LGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVA 351

Query: 303 KLAVKYKIPLHVDACLGGFLIV 324
            +  KYKI +HVDA  GG L++
Sbjct: 352 DICKKYKIWMHVDAAWGGGLLM 373


>gi|4503875 glutamate decarboxylase 2 [Homo sapiens]
          Length = 585

 Score = 40.4 bits (93), Expect = 0.004
 Identities = 43/142 (30%), Positives = 62/142 (43%), Gaps = 16/142 (11%)

Query: 199 GPDSCGCVTSGGTESILMACKAYRDLAF----EKGIKT-PEIVAPQSAHAAFN--KAASY 251
           G    G  + GG  S + A    R   F    EKG+   P ++A  S H+ F+  K A+ 
Sbjct: 232 GGSGDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAA 291

Query: 252 FGMKIVRVPLTKMME--------VDVRAMRRAISRNTAMLVCSTPQFP-HGVIDPVPEVA 302
            G+    V L K  E        ++ R +          LV +T     +G  DP+  VA
Sbjct: 292 LGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVA 351

Query: 303 KLAVKYKIPLHVDACLGGFLIV 324
            +  KYKI +HVDA  GG L++
Sbjct: 352 DICKKYKIWMHVDAAWGGGLLM 373


>gi|58331246 glutamate decarboxylase 1 isoform GAD67 [Homo sapiens]
          Length = 594

 Score = 37.0 bits (84), Expect = 0.049
 Identities = 15/33 (45%), Positives = 22/33 (66%)

Query: 292 HGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIV 324
           +G  DP+ E+A +  KY + LHVDA  GG L++
Sbjct: 350 YGAFDPIQEIADICEKYNLWLHVDAAWGGGLLM 382


>gi|4557289 alanine-glyoxylate aminotransferase [Homo sapiens]
          Length = 392

 Score = 35.0 bits (79), Expect = 0.18
 Identities = 28/100 (28%), Positives = 48/100 (48%), Gaps = 24/100 (24%)

Query: 293 GVIDPVPEVAKLAVKYKIPLHVD--ACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISAD 350
           GV+ P+    +L  +YK  L VD  A LGG  + +M++             +G+  + + 
Sbjct: 161 GVLQPLDGFGELCHRYKCLLLVDSVASLGGTPL-YMDR-------------QGIDILYSG 206

Query: 351 THKYGYAPKGSSLVLYSDK--------KYRNYQFFVDTDW 382
           + K   AP G+SL+ +SDK        K + + F++D  W
Sbjct: 207 SQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKW 246


>gi|194294551 cysteine sulfinic acid decarboxylase [Homo sapiens]
          Length = 520

 Score = 34.3 bits (77), Expect = 0.31
 Identities = 70/357 (19%), Positives = 131/357 (36%), Gaps = 33/357 (9%)

Query: 116 LPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHP 175
           L SQG S   +LE+ +            R    ++SG +    L  +   +   ++    
Sbjct: 87  LRSQGESQKQILERCRAVIRYSVKTGHPRFFNQLFSGLDPHA-LAGRIITESLNTSQYTY 145

Query: 176 DIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAF----EKGIK 231
           +I P    +E E++R   +L  G     G    GG+ S + A    R   +    ++G++
Sbjct: 146 EIAPVFVLMEEEVLRKLRALV-GWSSGDGIFCPGGSISNMYAVNLARYQRYPDCKQRGLR 204

Query: 232 TPEIVA---PQSAHAAFNKAASYFGMKIVRVPLTK------MMEVDVR---AMRRAISRN 279
           T   +A    +  H +  K A++ G+    V + K      M+  D+     M  A    
Sbjct: 205 TLPPLALFTSKECHYSIQKGAAFLGLGTDSVRVVKADERGKMVPEDLERQIGMAEAEGAV 264

Query: 280 TAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDF 339
             ++  ++     G  DP+  +A +  ++ + LHVDA  GG +++          H  D 
Sbjct: 265 PFLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGSVLLSQTH-----RHLLD- 318

Query: 340 RVKGVTSISADTHKYGYAPKGSSLVLYSDK---------KYRNYQFFVDTDWQGGIYASP 390
            ++   S++ + HK   A    S +L  D             +Y F  D  +   +    
Sbjct: 319 GIQRADSVAWNPHKLLAAGLQCSALLLQDTSNLLKRCHGSQASYLFQQDKFYDVALDTGD 378

Query: 391 TIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQ 447
            +            W      G+ G      Q    AR+L  E++  +G  +   P+
Sbjct: 379 KVVQCGRRVDCLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVMEPE 435


>gi|108773801 glycine dehydrogenase (decarboxylating) [Homo sapiens]
          Length = 1020

 Score = 32.3 bits (72), Expect = 1.2
 Identities = 65/296 (21%), Positives = 114/296 (38%), Gaps = 33/296 (11%)

Query: 157 TELLVKAYGDFAWSNPLHP-DIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSG--GTES 213
           +EL    + +FA  +P  P D   G +++  E+ +  C L  G    C    SG  G  +
Sbjct: 566 SELAPITWKEFANIHPFVPLDQAQGYQQLFRELEKDLCEL-TGYDQVCFQPNSGAQGEYA 624

Query: 214 ILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMR 273
            L   +AY +   E G +T  ++ P+SAH     +A   GMKI  V + K   +D   ++
Sbjct: 625 GLATIRAYLNQKGE-GHRTVCLI-PKSAHGTNPASAHMAGMKIQPVEVDKYGNIDAVHLK 682

Query: 274 RAISRNTAMLVCSTPQFP--HGVIDP-VPEVAKLAVKYKIPLHVDACLGGFLIVFMEKA- 329
             + ++   L      +P  +GV +  + +V  L  ++   +++D       +       
Sbjct: 683 AMVDKHKENLAAIMITYPSTNGVFEENISDVCDLIHQHGGQVYLDGANMNAQVGICRPGD 742

Query: 330 -GYPLEH---------PFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVD 379
            G  + H         P      G+  I    H   + P    + L  ++         D
Sbjct: 743 FGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLAPFLPNHPVISLKRNE---------D 793

Query: 380 TDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELE 435
               G + A+P  + S    I    WA +   G  G  +AT+  I  A ++   LE
Sbjct: 794 ACPVGTVSAAPWGSSS----ILPISWAYIKMMGGKGLKQATETAILNANYMAKRLE 845


>gi|132814448 dopa decarboxylase (aromatic L-amino acid
           decarboxylase) [Homo sapiens]
          Length = 480

 Score = 30.0 bits (66), Expect = 5.9
 Identities = 31/142 (21%), Positives = 55/142 (38%), Gaps = 18/142 (12%)

Query: 204 GCVTSGGTESILMACKAYRDLAFEK-GIKTPEIV-----------APQSAHAAFNKAASY 251
           G +    +E+ L+A  A R     +    +PE+            +   AH++  +A   
Sbjct: 142 GVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLI 201

Query: 252 FGMKIVRVPLTKMMEVDVRAMRRAISRNTA------MLVCSTPQFPHGVIDPVPEVAKLA 305
            G+K+  +P      +   A++ A+ R+ A       +V +         D + EV  + 
Sbjct: 202 GGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPIC 261

Query: 306 VKYKIPLHVDACLGGFLIVFME 327
            K  I LHVDA   G   +  E
Sbjct: 262 NKEDIWLHVDAAYAGSAFICPE 283


>gi|4503281 dopa decarboxylase (aromatic L-amino acid decarboxylase)
           [Homo sapiens]
          Length = 480

 Score = 30.0 bits (66), Expect = 5.9
 Identities = 31/142 (21%), Positives = 55/142 (38%), Gaps = 18/142 (12%)

Query: 204 GCVTSGGTESILMACKAYRDLAFEK-GIKTPEIV-----------APQSAHAAFNKAASY 251
           G +    +E+ L+A  A R     +    +PE+            +   AH++  +A   
Sbjct: 142 GVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLI 201

Query: 252 FGMKIVRVPLTKMMEVDVRAMRRAISRNTA------MLVCSTPQFPHGVIDPVPEVAKLA 305
            G+K+  +P      +   A++ A+ R+ A       +V +         D + EV  + 
Sbjct: 202 GGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPIC 261

Query: 306 VKYKIPLHVDACLGGFLIVFME 327
            K  I LHVDA   G   +  E
Sbjct: 262 NKEDIWLHVDAAYAGSAFICPE 283


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.135    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,305,633
Number of Sequences: 37866
Number of extensions: 927089
Number of successful extensions: 1894
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1886
Number of HSP's gapped (non-prelim): 13
length of query: 568
length of database: 18,247,518
effective HSP length: 108
effective length of query: 460
effective length of database: 14,157,990
effective search space: 6512675400
effective search space used: 6512675400
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.