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Search of human proteins with 31542246
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31542246 kelch-like 36 [Homo sapiens]
(616 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31542246 kelch-like 36 [Homo sapiens] 1266 0.0
gi|24308181 kelch-like 9 [Homo sapiens] 425 e-119
gi|45643138 kelch-like 13 [Homo sapiens] 420 e-117
gi|8922854 kelch-like 26 [Homo sapiens] 376 e-104
gi|156616301 kelch-like 32 [Homo sapiens] 326 3e-89
gi|24432026 kelch-like [Homo sapiens] 311 9e-85
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 310 2e-84
gi|55741643 kelch-like 14 [Homo sapiens] 267 2e-71
gi|23397572 kelch-like 34 [Homo sapiens] 263 5e-70
gi|226442729 kelch-like 15 [Homo sapiens] 247 3e-65
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 246 6e-65
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 246 6e-65
gi|166235129 kelch-like 3 [Homo sapiens] 232 9e-61
gi|40807500 kelch-like 20 [Homo sapiens] 226 6e-59
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 225 8e-59
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 225 8e-59
gi|55925604 kelch-like 18 [Homo sapiens] 224 2e-58
gi|34101268 kelch-like 8 [Homo sapiens] 209 8e-54
gi|38194229 kelch-like 17 [Homo sapiens] 202 6e-52
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 200 3e-51
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 199 5e-51
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 199 5e-51
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 199 5e-51
gi|14780904 kelch-like 1 protein [Homo sapiens] 198 1e-50
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 197 2e-50
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 195 1e-49
gi|11056006 kelch-like 12 [Homo sapiens] 194 2e-49
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 191 1e-48
gi|148664209 kelch-like 10 [Homo sapiens] 191 1e-48
gi|40018614 DRE1 protein [Homo sapiens] 189 8e-48
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 1266 bits (3275), Expect = 0.0
Identities = 616/616 (100%), Positives = 616/616 (100%)
Query: 1 MMEGSRQTRVSRPYKISESSKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAH 60
MMEGSRQTRVSRPYKISESSKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAH
Sbjct: 1 MMEGSRQTRVSRPYKISESSKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAH 60
Query: 61 RNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVL 120
RNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVL
Sbjct: 61 RNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVL 120
Query: 121 ETAHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSF 180
ETAHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSF
Sbjct: 121 ETAHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSF 180
Query: 181 TPDFLQNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPEREAHARQVLENIHFPLI 240
TPDFLQNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPEREAHARQVLENIHFPLI
Sbjct: 181 TPDFLQNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPEREAHARQVLENIHFPLI 240
Query: 241 PKNDLLHRVKPAVCSLLPKEANCEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFV 300
PKNDLLHRVKPAVCSLLPKEANCEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFV
Sbjct: 241 PKNDLLHRVKPAVCSLLPKEANCEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFV 300
Query: 301 GGEVSERCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGG 360
GGEVSERCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGG
Sbjct: 301 GGEVSERCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGG 360
Query: 361 DAASNLLYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPK 420
DAASNLLYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPK
Sbjct: 361 DAASNLLYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPK 420
Query: 421 TDSWSYVAGLPRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMT 480
TDSWSYVAGLPRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMT
Sbjct: 421 TDSWSYVAGLPRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMT 480
Query: 481 TARGWHSMCSLGDSIYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESG 540
TARGWHSMCSLGDSIYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESG
Sbjct: 481 TARGWHSMCSLGDSIYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESG 540
Query: 541 VAVWEGRIYILGGYSWENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVCALEPRPE 600
VAVWEGRIYILGGYSWENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVCALEPRPE
Sbjct: 541 VAVWEGRIYILGGYSWENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVCALEPRPE 600
Query: 601 DKKKKGKGKRHQDRGQ 616
DKKKKGKGKRHQDRGQ
Sbjct: 601 DKKKKGKGKRHQDRGQ 616
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 425 bits (1092), Expect = e-119
Identities = 224/578 (38%), Positives = 353/578 (61%), Gaps = 13/578 (2%)
Query: 28 HSSTVLQRLNEQRLRGLFCDVVLVADE--QRVPAHRNLLAVCSDYFNSMFTIGMREAFQK 85
HSS VLQ ++ R+ GL CDV LV + + P HR ++A SDYF +MFT GM+E
Sbjct: 32 HSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLM 91
Query: 86 EVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSE 145
++L G + +GLK ++DF+Y +L L+ N+ LE A LQI V+DFC +L VS
Sbjct: 92 CIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSL 151
Query: 146 DNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRE 205
DN + + +A+ Y+L +D +++ FIL +F L T +FL+ + ++L LSS+ ++
Sbjct: 152 DNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLK-LPFERLAFVLSSNSLKHC 210
Query: 206 CEHDLLQAALQWLTQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEG 265
E +L +AA +WL + R +A ++++NI FPL+ DL++ V+ + + C
Sbjct: 211 TELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTV--DFMRTDNTCVN 268
Query: 266 FIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCYLDAKSEQW 325
+ EA Y QPVMQ+ RTA+R++ L+ +GG + ++ L +S + D ++++W
Sbjct: 269 LLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQ-LVVSKELRMYDERAQEW 327
Query: 326 VKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMNQ 385
P+ A R H +AV+G F+++ GG + D G A + ++R+DPR +W++VAS+N+
Sbjct: 328 RSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNE 387
Query: 386 RRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDF 445
+R F+L++++ L A+GGR+ G L++VE Y+P+ + WSYVA + YGHAGT+Y
Sbjct: 388 KRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGL 447
Query: 446 VYISGG--HDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDD 503
+YISGG HD ++ L+C+D TD W ++ PMTT RG H MC++GD +Y IGG+
Sbjct: 448 MYISGGITHD----TFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHF 503
Query: 504 NIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSK 563
S + DVL E YSP +QWT +A +L S+ GVAV+E +IY++GGYSW N +
Sbjct: 504 RGTS-DYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVE 562
Query: 564 TVQVYDREADKWSRGVDLPKAIAGGSACVCALEPRPED 601
VQ YD E D+W + DLP+++ G AC + P E+
Sbjct: 563 IVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEEN 600
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 420 bits (1079), Expect = e-117
Identities = 221/585 (37%), Positives = 353/585 (60%), Gaps = 13/585 (2%)
Query: 20 SKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADE--QRVPAHRNLLAVCSDYFNSMFTI 77
++++ HSS VLQ ++ RL GL CDV L+ + P HR ++A SDYF +MFT
Sbjct: 66 TRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTG 125
Query: 78 GMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCE 137
GM+E ++L G S +GL+ ++DF+Y +L L+ N+ LE A LQI V+DFC
Sbjct: 126 GMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKV 185
Query: 138 YLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYL 197
+L V+ DN + + +A+ Y+L +D +++ F+L +F L T +FL+ + ++L L
Sbjct: 186 FLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLK-LPFERLAFVL 244
Query: 198 SSSEVQRECEHDLLQAALQWLTQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLL 257
SS+ ++ E +L +A +WL + R A ++++NI FPL+ +L++ V+ +
Sbjct: 245 SSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTV--DFM 302
Query: 258 PKEANCEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCY 317
+ C + EA Y QPVMQ+ RTA+R++ L+ +GG + ++ L +S +
Sbjct: 303 RTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQ-LVVSKELRM 361
Query: 318 LDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQW 377
D K+ +W P+ A R H +AV+G F+++ GG + D G A + ++R+DPR +W
Sbjct: 362 YDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421
Query: 378 IKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGH 437
++VAS+N++R F+L++++ L A+GGRN G L +VE Y+P+T+ W+YVA + YGH
Sbjct: 422 MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGH 481
Query: 438 AGTIYKDFVYISGG--HDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSI 495
AGT+Y +YISGG HD ++K L+C+D TD W ++ PMTT RG H MC++G+ +
Sbjct: 482 AGTVYGGVMYISGGITHD----TFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERL 537
Query: 496 YSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYS 555
Y IGG+ S + DVL E YSP +QWT +A +L S+ GVAV+E +IY++GGYS
Sbjct: 538 YVIGGNHFRGTS-DYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYS 596
Query: 556 WENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVCALEPRPE 600
W N + VQ YD + D+W + DLP+++ G AC + P E
Sbjct: 597 WNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEE 641
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 376 bits (965), Expect = e-104
Identities = 213/573 (37%), Positives = 324/573 (56%), Gaps = 9/573 (1%)
Query: 28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEV 87
HS+++LQ L R +G DVVL + + PAH+ +LA CSDYF +MFT GMREA Q +
Sbjct: 45 HSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVI 104
Query: 88 ELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
EL G S GL+ ++DF Y E+ LD + VL A LQ+ VV+ C E+L+ +S +
Sbjct: 105 ELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVET 164
Query: 148 YLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECE 207
L + ++A+ +SL L +D F HF ++ DFL+ + +++L +L S+ +Q E
Sbjct: 165 CLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLR-LPLERLVFFLQSNRLQSCAE 223
Query: 208 HDLLQAALQWLTQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGFI 267
DL +AA++WL P R A VL +I FPL+ ++L+ V+ ++ ++ C ++
Sbjct: 224 IDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQ--TLDIMVEDVLCRQYL 281
Query: 268 EEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGG-EVSERCLELSDDTCYLDAKSEQWV 326
EA Y Q MQ+ RTA+R++ L+ GG ++ +S L +
Sbjct: 282 LEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARHF 341
Query: 327 KE-TPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMNQ 385
+E T + SH CVAVL F+++AGG + G+ A + YRYDP +W+++ +M +
Sbjct: 342 RELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQE 401
Query: 386 RRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDF 445
R+ F L + M+ A GGRN G+L+SVE Y P+ + W Y L R T+GHAG
Sbjct: 402 SRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGGR 461
Query: 446 VYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDNI 505
+YISGG+ + +K L CYD D WE + PM+ R H+M G IY++GG D++
Sbjct: 462 LYISGGYGISVED-KKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHV 520
Query: 506 ESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTV 565
+ FDVL VE Y P+ +QWT V+P+ SE+G + E +IYI+GGY+W + V
Sbjct: 521 DRC--FDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTGIV 578
Query: 566 QVYDREADKWSRGVDLPKAIAGGSACVCALEPR 598
QVY+ + D+W R + P++ A G AC L PR
Sbjct: 579 QVYNTDTDEWERDLHFPESFA-GIACAPVLLPR 610
>gi|156616301 kelch-like 32 [Homo sapiens]
Length = 620
Score = 326 bits (836), Expect = 3e-89
Identities = 205/578 (35%), Positives = 308/578 (53%), Gaps = 20/578 (3%)
Query: 28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEV 87
H+ +VL LN+QR G+ CD+ L+A+EQ+ AH+ +LA CSDYF +MF++ M E+ EV
Sbjct: 24 HNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADEV 83
Query: 88 ELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
L G + +GLK ++F Y G+++L+ G I VL LQ+ +++ C YL QE++ N
Sbjct: 84 NLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFN 143
Query: 148 YLYLQELASIYSLKRLDAFIDGFILNHFG-TLSFTPDFLQNVSMQKLCVYLSSSEVQREC 206
YL L LA +++L L+ + F++ H L P+ + + L L S +
Sbjct: 144 YLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLS 203
Query: 207 EHDLLQAALQWLTQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGF 266
E + Q A++WL + + ++L+ I F L+ D LH V + L+
Sbjct: 204 EEQIWQLAVRWLEHNCHYQ-YMDELLQYIRFGLMDV-DTLHTVALS-HPLVQASETATAL 260
Query: 267 IEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERC-------LELSDDTCYLD 319
+ EA+ YH ++ AQPV QT+RT R + L +GG+ E C D L
Sbjct: 261 VNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENALI 320
Query: 320 AKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIK 379
A W + P+P RSHHCVAV+G F+F+AGG +G A RYDPR W +
Sbjct: 321 AAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAE 380
Query: 380 VASMNQRRVDFYLASIEDMLVAIGGRNE-NGALSSVETYSPKTDSWSYVAGLPRFTYGHA 438
+A M R F L ++E+ L A+GGRNE L +VE Y PK + W++V R HA
Sbjct: 381 IAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHA 440
Query: 439 GTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSI 498
G + ++ISGG Y+ L+ Y+ + W R PM R +HSM ++ +Y +
Sbjct: 441 GYVADGLLWISGGVT-NTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVL 499
Query: 499 GGSDDNIESMERFDVLGVEAYSPQCNQWTRV-APLLHANSESGVAVWEGRIYILGGYS-W 556
GG+D + + +R V +++Y+ +QWTR LL +ESGVAV GRIY++GGYS W
Sbjct: 500 GGNDLDYNN-DRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYSIW 558
Query: 557 ENTAFSKTVQVYD--REA-DKWSRGVDLPKAIAGGSAC 591
N + +QV D RE ++ G LP A G +AC
Sbjct: 559 TNEPLA-CIQVLDVSREGKEEVFYGPTLPFASNGIAAC 595
>gi|24432026 kelch-like [Homo sapiens]
Length = 634
Score = 311 bits (798), Expect = 9e-85
Identities = 198/585 (33%), Positives = 305/585 (52%), Gaps = 24/585 (4%)
Query: 20 SKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGM 79
+ YR A HS +L+ L R G+ DVVLV + + + AHR LLA DYF MF G+
Sbjct: 24 NNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGL 83
Query: 80 REAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYL 139
+E Q+EV + G SY + ++ F+Y EL L N+ L A LQI ++ FCC++L
Sbjct: 84 KEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFL 143
Query: 140 EQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSS 199
V E+N L + LA ++ L RL +D +IL +F S T + Q + ++K+ LSS
Sbjct: 144 MSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQ-LPLEKVYSLLSS 202
Query: 200 SEVQRECEHDLLQAALQWLTQQPEREA------HARQVLENIHFPLIPKNDLLHRVKPAV 253
+ ++ CE ++ + AL + + +A ++LE + FPL+ + ++L R+ +
Sbjct: 203 NRLEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLM-EAEVLQRLHDKL 261
Query: 254 CSLLPKEANCEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSD 313
+ + A+ YH N + QP +Q+ +T LR++ + ++ GG S LSD
Sbjct: 262 -----DPSPLRDTVASALMYHRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSD 316
Query: 314 DTCYLDAKSEQWVKET-PLPARRSHHCVAVLGGFIFIAGGSFSRDNG--GDAASNLLYRY 370
YL+ +W T L R S+ +AVL F+++ GG DN G A + +RY
Sbjct: 317 QAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGG----DNNVQGFRAESRCWRY 372
Query: 371 DPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGL 430
DPR +W ++ S+ Q D + + + A+ GR+ + L++VE Y P T+SW+YVA L
Sbjct: 373 DPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPL 432
Query: 431 PRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCS 490
R Y HAG + +YI+ G + Y K CYD ++ W R WH M +
Sbjct: 433 KREVYAHAGATLEGKMYITCGRRGE--DYLKETHCYDPGSNTWHTLADGPVRRAWHGMAT 490
Query: 491 LGDSIYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYI 550
L + +Y IGGS N ++ R DV V YS QW+ V PL + E G+AV + RIY+
Sbjct: 491 LLNKLYVIGGS--NNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYV 548
Query: 551 LGGYSWENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVCAL 595
LGG S + + V +YD E D W G L +I+G +ACV L
Sbjct: 549 LGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTL 593
>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
sapiens]
Length = 634
Score = 310 bits (795), Expect = 2e-84
Identities = 185/572 (32%), Positives = 300/572 (52%), Gaps = 12/572 (2%)
Query: 26 ADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQK 85
A + +L+ L++ R CD+V+ + H++++A CS+YF + I ++ +
Sbjct: 53 ASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYF---YNILKKDPSIQ 109
Query: 86 EVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSE 145
V+L S +GL V+ + Y G+L L I ++ A LQI T+V C ++L +E+S
Sbjct: 110 RVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSV 169
Query: 146 DNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRE 205
+N +Y+ +A YSLK A FI ++F + + F++ ++ +++ L ++Q
Sbjct: 170 ENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMK-LTFEQINELLIDDDLQLP 228
Query: 206 CEHDLLQAALQWLTQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEG 265
E Q A++WL +R +A +L NI F I DL++ V+ + ++A+C
Sbjct: 229 SEIVAFQIAMKWLEFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSV--PRMMQDADCHR 286
Query: 266 FIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCYLDAKSEQW 325
+ +A+ YH Q +Q++RT +R L+ VGG LS D Y D ++ W
Sbjct: 287 LLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPENG-W 345
Query: 326 VKETPLPARRSHHCVAVLGGFIFIAGGSFSRD--NGGDAASNLLYRYDPRCKQWIKVASM 383
K T +PA+ + CVAV+ GF+++AGG D N A + RYDPR WI +ASM
Sbjct: 346 SKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASM 405
Query: 384 NQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYK 443
NQ+R F L+ ++ A GGRN G+L+S+E Y P T+ W L HA +
Sbjct: 406 NQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVAD 465
Query: 444 DFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDD 503
V ++GG Y Y +++ YD +D W+E ++T RGWH +L D +Y +GGS
Sbjct: 466 GRVLVTGG--YIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQL 523
Query: 504 NIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSK 563
ER DVL VE YSP QW+ APL S +GV+ GR Y++GG++ + K
Sbjct: 524 GPRG-ERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKK 582
Query: 564 TVQVYDREADKWSRGVDLPKAIAGGSACVCAL 595
+Q + E ++W+ +LP+A G S C ++
Sbjct: 583 CIQCFSPELNEWTEDDELPEATVGVSCCTLSM 614
>gi|55741643 kelch-like 14 [Homo sapiens]
Length = 628
Score = 267 bits (683), Expect = 2e-71
Identities = 161/512 (31%), Positives = 262/512 (51%), Gaps = 20/512 (3%)
Query: 89 LIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNY 148
L G S IGL+ V+++LY + L ++ VL + +L I V C ++L ++S NY
Sbjct: 127 LQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNY 186
Query: 149 LYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECEH 208
+ ++A+++ L+ + +++ L+F +++ L S E E
Sbjct: 187 KQVCKIAALHGLEETKKLANKYLVEDVLLLNF----------EEMRALLDSLPPPVESEL 236
Query: 209 DLLQAALQWLTQQPE-REAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGFI 267
L Q ++ WL E R +A +++ + F LIP +L+ RV+ + + C+ +
Sbjct: 237 ALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSV--DFMRTDPVCQKLL 294
Query: 268 EEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCYLDAKSEQWVK 327
+A+ YH Q Q+ + +R+N++ LL VGG S+ Y D + + W
Sbjct: 295 LDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKI 354
Query: 328 ETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMNQRR 387
T +P +HHCV + F+F+ GG + G ++N + RYDPR WI++ M +RR
Sbjct: 355 LTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERR 414
Query: 388 VDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDFVY 447
FY ++ L IGGRNE G LSSVE Y+ +T+ W YV+ LP+ HAG ++ +Y
Sbjct: 415 ASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIY 474
Query: 448 ISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDNIES 507
ISGG G Y L CYD DVW ++ M T R H++ + D +Y+IGG ++++
Sbjct: 475 ISGG--VHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGG--NHLKG 530
Query: 508 MERFDVLGVEAYSPQCNQWTRV-APLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQ 566
DV+ VE Y P+ +QW + P+L S G AV + IY++GGYSW A+ +
Sbjct: 531 FSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTI 590
Query: 567 VYDREADKWSR-GVDLPKAIAGGSACVCALEP 597
Y E W+ D+ + +A G ACV + P
Sbjct: 591 CYCPEKGTWTELEGDVAEPLA-GPACVTVILP 621
Score = 45.8 bits (107), Expect = 1e-04
Identities = 22/49 (44%), Positives = 29/49 (59%)
Query: 28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFT 76
HS +L LN + LFCDV L A Q+ H+ +LA CS YF S+F+
Sbjct: 15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
>gi|23397572 kelch-like 34 [Homo sapiens]
Length = 644
Score = 263 bits (671), Expect = 5e-70
Identities = 193/641 (30%), Positives = 294/641 (45%), Gaps = 73/641 (11%)
Query: 28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEV 87
H +L R G CDV L + PAHR+LLA SDYF ++F +E+ + +
Sbjct: 11 HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVI 70
Query: 88 ELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
L S GL+ ++DF+Y L L ++ LE A LQ+ + C YLE++++ +N
Sbjct: 71 HLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPEN 130
Query: 148 YLYLQELASIYSLKRLDAFIDGFILNHFGTL---SFTPDFLQNVSMQKLCVYLSSSEVQR 204
+ +A+ + L + I++H L P L ++ L L + +V R
Sbjct: 131 CCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDVAR 190
Query: 205 ECEHDLLQAALQWLTQQP--EREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEAN 262
E LL AL WL Q+P ER AH ++LE + F L+P D+L RV +LP A
Sbjct: 191 VPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLVPA-DVLRRVYSGSGLVLP--AR 247
Query: 263 CEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGG-------------------- 302
+G I +A+ YH + QP+MQ ++T++R+ Q R+L VGG
Sbjct: 248 VKGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARG 307
Query: 303 ----------------EVSERCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGF 346
E E EL+ + D + +W T LP H V G F
Sbjct: 308 QVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNF 367
Query: 347 IFIAGGSFSRDNGGDAASNL----------LYRYDPRCKQWIKVASMNQRRVDFYLASIE 396
+F+ GG G A+S L ++RYDPR W +V +M + R F+ ++
Sbjct: 368 LFVLGG---ESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVG 424
Query: 397 DMLVAIGGRNENG-ALSSVETYSPKTDSWSYVAGLPRFTYGHAGTI-YKDFVYISG---G 451
+ L+A+GG G L+SVE Y + D W+ LPR +GHAG + + VYISG G
Sbjct: 425 ERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAG 484
Query: 452 HDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDNIESMERF 511
++L VW ++ PM TAR H M L ++++ G + +ER+
Sbjct: 485 RGEGGASSLRDLYVLGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSEIERY 544
Query: 512 DVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQV--YD 569
D P +QWTR+ PL + G+AV E +LGG W ++ T V YD
Sbjct: 545 D--------PGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYD 596
Query: 570 READKWSR-GVDLPKAIAGGSACVCALEPRPEDKKKKGKGK 609
+ D+W G LP A +G V L +D+++ G+
Sbjct: 597 LDLDRWEDIGCALPWAWSGLRCAVLQLAEGGDDEREGEVGE 637
>gi|226442729 kelch-like 15 [Homo sapiens]
Length = 604
Score = 247 bits (630), Expect = 3e-65
Identities = 162/567 (28%), Positives = 269/567 (47%), Gaps = 28/567 (4%)
Query: 28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEV 87
H ++V GL DV LV ++ + AH+ LLA SDYF MFT MRE Q ++
Sbjct: 13 HDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKI 72
Query: 88 ELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
L G + G V+ F+Y G + L + +L+ A +Q+ VV FCC +L ++ +N
Sbjct: 73 HLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLEN 132
Query: 148 YLYLQELASIY--SLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRE 205
+ L + +++ + +D F+L++F L PDFL +S +KL YL + + R
Sbjct: 133 CAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRF 192
Query: 206 CEHDLLQAALQWLTQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEG 265
E +L +A WL R H +++NI F L+ + +VK + ++ E
Sbjct: 193 PEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYE- 251
Query: 266 FIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCYLDAKSEQW 325
+++A+ Y N+ QP++ K + +R+ + + G + + + L W
Sbjct: 252 -VDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMV--NSKILLLKKPRVWW 308
Query: 326 VKETP-LPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMN 384
E P +P R C+A++ F+F+ GG +G AS+ ++RYDPR W+++A M+
Sbjct: 309 ELEGPQVPLRPD--CLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMS 366
Query: 385 QRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKD 444
R +F + I + A+ GR + S E Y D W +V P YGH GT+ +
Sbjct: 367 VPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNN 426
Query: 445 FVYISGGHDYQIGPYRKNLLCYD-----------HRTDV----WEERRPMTTARGWHSMC 489
++I+GG K + +D RT V WE + M AR +H M
Sbjct: 427 KLFITGG--ITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMI 484
Query: 490 SLGDSIYSIGGSDDNIE-SMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRI 548
S +Y GG + S E E Y+P+ +QWT +A + S GV V + +I
Sbjct: 485 SYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQI 544
Query: 549 YILGGYSWENTAFSKTVQVYDREADKW 575
+LGG + N +S ++ +D + +KW
Sbjct: 545 MVLGGLCY-NGHYSDSILTFDPDENKW 570
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 246 bits (627), Expect = 6e-65
Identities = 157/553 (28%), Positives = 275/553 (49%), Gaps = 23/553 (4%)
Query: 28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEV 87
H + +NE R + L CDV +VA++ + AHR +LA CS YF++MFT M E+ K V
Sbjct: 42 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 101
Query: 88 ELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
+ L+ ++D++Y E+ + N+ +L A LLQ+ V CCE+LE ++ N
Sbjct: 102 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 161
Query: 148 YLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECE 207
L ++ A +++ L + + HF + + +FL N+ ++++C +SS ++ E
Sbjct: 162 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFL-NLGIEQVCSLISSDKLTISSE 220
Query: 208 HDLLQAALQWLTQQPE-REAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGF 266
+ +A + W+ + R+ +++E++ PL+P+ L+ RV+ +L+ + C+ +
Sbjct: 221 EKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEE--ALVKNSSACKDY 278
Query: 267 IEEAVRYHNNLAAQPV-MQTKRTALRT--NQERLLFVGGEVSERCLELSDDTCYLDAKSE 323
+ EA++YH Q + M++ RT LRT N +L+ V G + + + + CY D K E
Sbjct: 279 LIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVE--CY-DFKEE 335
Query: 324 QWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASM 383
+W + LP+RR + + G +F GG G + YDP QW VA+M
Sbjct: 336 RWHQVAELPSRRCRAGMVYMAGLVFAVGGF-----NGSLRVRTVDSYDPVKDQWTSVANM 390
Query: 384 NQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYK 443
RR A + +L A+GG + + LSSVE Y+ K++ W +VA + +
Sbjct: 391 RDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 450
Query: 444 DFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDD 503
+Y GG+D + CY+ T+ W M+T R + L + +Y++GG D
Sbjct: 451 GLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDG 510
Query: 504 NIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSK 563
+ VE Y P N W +VA + +GV G +Y++GG + +
Sbjct: 511 PLVRK------SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD--DGSCNLA 562
Query: 564 TVQVYDREADKWS 576
+V+ Y+ DKW+
Sbjct: 563 SVEYYNPTTDKWT 575
Score = 64.7 bits (156), Expect = 2e-10
Identities = 45/150 (30%), Positives = 69/150 (46%), Gaps = 10/150 (6%)
Query: 297 LLFVGGE--VSERCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSF 354
L VGG S +CL + CY +A + +W + RRS V VL ++ GG
Sbjct: 453 LYAVGGYDGASRQCLSTVE--CY-NATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG-- 507
Query: 355 SRDNGGDAASNLLYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSV 414
+ G + YDP W +VA MN R + + ++ +L +GG + + L+SV
Sbjct: 508 ---HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASV 564
Query: 415 ETYSPKTDSWSYVAGLPRFTYGHAGTIYKD 444
E Y+P TD W+ V+ +AG D
Sbjct: 565 EYYNPTTDKWTVVSSCMSTGRSYAGVTVID 594
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 246 bits (627), Expect = 6e-65
Identities = 157/553 (28%), Positives = 275/553 (49%), Gaps = 23/553 (4%)
Query: 28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEV 87
H + +NE R + L CDV +VA++ + AHR +LA CS YF++MFT M E+ K V
Sbjct: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
Query: 88 ELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
+ L+ ++D++Y E+ + N+ +L A LLQ+ V CCE+LE ++ N
Sbjct: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
Query: 148 YLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECE 207
L ++ A +++ L + + HF + + +FL N+ ++++C +SS ++ E
Sbjct: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFL-NLGIEQVCSLISSDKLTISSE 216
Query: 208 HDLLQAALQWLTQQPE-REAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGF 266
+ +A + W+ + R+ +++E++ PL+P+ L+ RV+ +L+ + C+ +
Sbjct: 217 EKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEE--ALVKNSSACKDY 274
Query: 267 IEEAVRYHNNLAAQPV-MQTKRTALRT--NQERLLFVGGEVSERCLELSDDTCYLDAKSE 323
+ EA++YH Q + M++ RT LRT N +L+ V G + + + + CY D K E
Sbjct: 275 LIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVE--CY-DFKEE 331
Query: 324 QWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASM 383
+W + LP+RR + + G +F GG G + YDP QW VA+M
Sbjct: 332 RWHQVAELPSRRCRAGMVYMAGLVFAVGGF-----NGSLRVRTVDSYDPVKDQWTSVANM 386
Query: 384 NQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYK 443
RR A + +L A+GG + + LSSVE Y+ K++ W +VA + +
Sbjct: 387 RDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 446
Query: 444 DFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDD 503
+Y GG+D + CY+ T+ W M+T R + L + +Y++GG D
Sbjct: 447 GLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDG 506
Query: 504 NIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSK 563
+ VE Y P N W +VA + +GV G +Y++GG + +
Sbjct: 507 PLVRK------SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD--DGSCNLA 558
Query: 564 TVQVYDREADKWS 576
+V+ Y+ DKW+
Sbjct: 559 SVEYYNPTTDKWT 571
Score = 64.7 bits (156), Expect = 2e-10
Identities = 45/150 (30%), Positives = 69/150 (46%), Gaps = 10/150 (6%)
Query: 297 LLFVGGE--VSERCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSF 354
L VGG S +CL + CY +A + +W + RRS V VL ++ GG
Sbjct: 449 LYAVGGYDGASRQCLSTVE--CY-NATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG-- 503
Query: 355 SRDNGGDAASNLLYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSV 414
+ G + YDP W +VA MN R + + ++ +L +GG + + L+SV
Sbjct: 504 ---HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASV 560
Query: 415 ETYSPKTDSWSYVAGLPRFTYGHAGTIYKD 444
E Y+P TD W+ V+ +AG D
Sbjct: 561 EYYNPTTDKWTVVSSCMSTGRSYAGVTVID 590
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 232 bits (591), Expect = 9e-61
Identities = 152/554 (27%), Positives = 272/554 (49%), Gaps = 25/554 (4%)
Query: 28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEV 87
H + +NE R + L CDV++VA++ + AHR +LA CS YF +MFT M E+ K++
Sbjct: 32 HMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKI 91
Query: 88 ELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
E+ L ++D++Y E+ + N+ +L A LLQ+ V CC++L+ ++ N
Sbjct: 92 EIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTN 151
Query: 148 YLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECE 207
L ++ A +++ L + + HF + +FL ++S+ ++C +SS ++ E
Sbjct: 152 CLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFL-SLSLDQVCSLISSDKLTVSSE 210
Query: 208 HDLLQAALQWLTQQPE-REAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGF 266
+ +A + W+ + E R H +++E++ PL+P++ L+ V+ +L+ C+ F
Sbjct: 211 EKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEE--ALIKNNNTCKDF 268
Query: 267 IEEAVRYH-NNLAAQPVMQTKRTALRTN---QERLLFVGGEVSERCLELSDDTCYLDAKS 322
+ EA++YH L + +++ RT RT + ++ VGG+ + + CY D +
Sbjct: 269 LIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVE---CY-DFEE 324
Query: 323 EQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVAS 382
++W + LP+RR V + G ++ GG G + YD QW +AS
Sbjct: 325 DRWDQIAELPSRRCRAGVVFMAGHVYAVGGF-----NGSLRVRTVDVYDGVKDQWTSIAS 379
Query: 383 MNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIY 442
M +RR A + D+L A+GG + + L+SVE YS KT+ W +VA + +
Sbjct: 380 MQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVV 439
Query: 443 KDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSD 502
+ +Y GG+D + Y+ T+ W M+T R + L +Y+ GG D
Sbjct: 440 EGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHD 499
Query: 503 DNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFS 562
+ VE Y P N W +VA + +GV G +Y++GG + +
Sbjct: 500 GPLVRK------SVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGD--DGSCNL 551
Query: 563 KTVQVYDREADKWS 576
+V+ Y+ DKW+
Sbjct: 552 ASVEYYNPVTDKWT 565
Score = 84.3 bits (207), Expect = 3e-16
Identities = 59/204 (28%), Positives = 91/204 (44%), Gaps = 19/204 (9%)
Query: 394 SIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDFVYISGGHD 453
S+ +++ +GG+ A+ SVE Y + D W +A LP AG ++ GH
Sbjct: 298 SLPKVMIVVGGQAPK-AIRSVECYDFEEDRWDQIAELPSRRC-RAGVVFM------AGHV 349
Query: 454 YQIGPYRKNLLC-----YDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDNIESM 508
Y +G + +L YD D W M R L D +Y++GG D +
Sbjct: 350 YAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGST--- 406
Query: 509 ERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQVY 568
+ VEAYS + N+W VAP+ S GV V EG++Y +GGY + TV+ Y
Sbjct: 407 ---GLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQY 463
Query: 569 DREADKWSRGVDLPKAIAGGSACV 592
+ ++W D+ +G V
Sbjct: 464 NPATNEWIYVADMSTRRSGAGVGV 487
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 226 bits (575), Expect = 6e-59
Identities = 159/554 (28%), Positives = 264/554 (47%), Gaps = 28/554 (5%)
Query: 28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEV 87
H L+ +N R CDVVLV +++ AHR +L+ CS YF +MFT + E+ Q EV
Sbjct: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 109
Query: 88 ELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
+ ++ ++DF Y ++ ++ GN+ +L A LLQ+ + + CCE+L++++ N
Sbjct: 110 VIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 169
Query: 148 YLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECE 207
L ++ A +S + L D F ++F + + +F+ + +L +SS E+ E
Sbjct: 170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFML-LPANQLIDIISSDELNVRSE 228
Query: 208 HDLLQAALQWLTQQ-PEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGF 266
+ A + W+ ER QVL+++ PL+ L+ V L+ + C
Sbjct: 229 EQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTV--GSDPLIKSDEECRDL 286
Query: 267 IEEAVRYHNNLAAQPVMQTKRTALRTN---QERLLFVGGEVSERCLELSDDTCYLDAKSE 323
++EA Y +P+MQ RT R E L VGG S + + D ++
Sbjct: 287 VDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVE---RYDPQTN 343
Query: 324 QWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIK-VAS 382
+W + RR V+VL ++ GG + G + N + RYDP+ QW VA
Sbjct: 344 EWRMVASMSKRRCGVGVSVLDDLLYAVGG-----HDGSSYLNSVERYDPKTNQWSSDVAP 398
Query: 383 MNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIY 442
+ R +A + L A+GG++ L+ VE Y PK + W+ VA + G A +
Sbjct: 399 TSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVL 458
Query: 443 KDFVYISGGHDYQIGPYRKNLL-CYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGS 501
F+Y GG D G N + Y+ + + W PM T R D IY++GG
Sbjct: 459 GGFLYAVGGSD---GTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGR 515
Query: 502 DDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAF 561
DD E + E Y+P+ NQW+ V + S G+AV G++ +GG+ + T +
Sbjct: 516 DDTTE------LSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGF--DGTTY 567
Query: 562 SKTVQVYDREADKW 575
KT++V+D +A+ W
Sbjct: 568 LKTIEVFDPDANTW 581
Score = 61.2 bits (147), Expect = 3e-09
Identities = 46/176 (26%), Positives = 69/176 (39%), Gaps = 45/176 (25%)
Query: 297 LLFVGGEVSERCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGS--- 353
L VGG+ CL + + D K +W + + RR VAVLGGF++ GGS
Sbjct: 415 LYAVGGQDGVSCLNIVER---YDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGT 471
Query: 354 -----FSRDN-------------------GGDAASNLLY---------------RYDPRC 374
R N G +++Y RY+PR
Sbjct: 472 SPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRT 531
Query: 375 KQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGL 430
QW V +M RR LA + L+A+GG + L ++E + P ++W G+
Sbjct: 532 NQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGM 587
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 225 bits (574), Expect = 8e-59
Identities = 162/582 (27%), Positives = 279/582 (47%), Gaps = 24/582 (4%)
Query: 19 SSKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIG 78
S + ++ +H+ +++ CDV+LVA ++R+PAHR +L+ SDYF +MFT
Sbjct: 147 SDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTND 206
Query: 79 MREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEY 138
+REA Q+E+++ G L +++ + Y G L L NI+ +L TA LLQ+ VV+ CC++
Sbjct: 207 VREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKF 266
Query: 139 LEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLS 198
L +++ N L ++ A L + + HF + +F+ + ++ L+
Sbjct: 267 LMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVL-LPASEIAKLLA 325
Query: 199 SSEVQRECEHDLLQAALQWLTQQPE-REAHARQVLENIHFPLIPKNDLLHRVKPAVCSLL 257
S ++ E +L A L W+ E R ++L I PL+ L L
Sbjct: 326 SDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNV---LF 382
Query: 258 PKEANCEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLF-VGGEVSERCLELSDDTC 316
+ C+ I EA++YH +P++Q+ RT R + LF VGG S + +
Sbjct: 383 RDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEK-- 440
Query: 317 YLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQ 376
D ++ W + RR VAVL +++ GG RD G N + Y+P+ K
Sbjct: 441 -YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG---RD--GLKTLNTVECYNPKTKT 494
Query: 377 WIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGL--PRFT 434
W + M+ R +A +E + A+GG + L++VE + P+ W++VA + PR T
Sbjct: 495 WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRST 554
Query: 435 YGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDS 494
G A + +Y GG D K++ C+D T+ W M+ RG + +
Sbjct: 555 VGVA--VLSGKLYAVGGRDG--SSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGL 610
Query: 495 IYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGY 554
+Y+IGG D ++ VE Y P+ + WT VA + + GV + ++Y +GGY
Sbjct: 611 LYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGY 670
Query: 555 SWENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVCALE 596
+ A+ TV+ YD + ++W++ P + ACV ++
Sbjct: 671 --DGQAYLNTVEAYDPQTNEWTQVA--PLCLGRAGACVVTVK 708
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 225 bits (574), Expect = 8e-59
Identities = 162/582 (27%), Positives = 279/582 (47%), Gaps = 24/582 (4%)
Query: 19 SSKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIG 78
S + ++ +H+ +++ CDV+LVA ++R+PAHR +L+ SDYF +MFT
Sbjct: 193 SDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTND 252
Query: 79 MREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEY 138
+REA Q+E+++ G L +++ + Y G L L NI+ +L TA LLQ+ VV+ CC++
Sbjct: 253 VREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKF 312
Query: 139 LEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLS 198
L +++ N L ++ A L + + HF + +F+ + ++ L+
Sbjct: 313 LMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVL-LPASEIAKLLA 371
Query: 199 SSEVQRECEHDLLQAALQWLTQQPE-REAHARQVLENIHFPLIPKNDLLHRVKPAVCSLL 257
S ++ E +L A L W+ E R ++L I PL+ L L
Sbjct: 372 SDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNV---LF 428
Query: 258 PKEANCEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLF-VGGEVSERCLELSDDTC 316
+ C+ I EA++YH +P++Q+ RT R + LF VGG S + +
Sbjct: 429 RDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEK-- 486
Query: 317 YLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQ 376
D ++ W + RR VAVL +++ GG RD G N + Y+P+ K
Sbjct: 487 -YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG---RD--GLKTLNTVECYNPKTKT 540
Query: 377 WIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGL--PRFT 434
W + M+ R +A +E + A+GG + L++VE + P+ W++VA + PR T
Sbjct: 541 WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRST 600
Query: 435 YGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDS 494
G A + +Y GG D K++ C+D T+ W M+ RG + +
Sbjct: 601 VGVA--VLSGKLYAVGGRDG--SSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGL 656
Query: 495 IYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGY 554
+Y+IGG D ++ VE Y P+ + WT VA + + GV + ++Y +GGY
Sbjct: 657 LYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGY 716
Query: 555 SWENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVCALE 596
+ A+ TV+ YD + ++W++ P + ACV ++
Sbjct: 717 --DGQAYLNTVEAYDPQTNEWTQVA--PLCLGRAGACVVTVK 754
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 224 bits (571), Expect = 2e-58
Identities = 158/546 (28%), Positives = 257/546 (47%), Gaps = 26/546 (4%)
Query: 36 LNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYI 95
+ E R +G CDV L + + AHR +LA YF++MFT M E Q E+ + G
Sbjct: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
Query: 96 GLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELA 155
L+A+++F Y G L +D N+ +L A LQ+ ++ D CC +L + + N L +++ A
Sbjct: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
Query: 156 SIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECEHDLLQAAL 215
L + FI HF +S + +FL + ++ + +S E+ + E + +AAL
Sbjct: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLA-LPLEDVLELVSRDELNVKSEEQVFEAAL 206
Query: 216 QWLT-QQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGFIEEAVRYH 274
W+ + +R + ++L NI PL L RV+ L+ C ++EA YH
Sbjct: 207 AWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQD--DLVRCCHKCRDLVDEAKDYH 264
Query: 275 NNLAAQPVMQTKRTALR--TNQERLLFVGGEVSERCLELSDDTCYLDAKSEQWVKETPLP 332
+P + RT R T+ L++ G ++ L+ + D + W + P+
Sbjct: 265 LMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVF-DPIANCWERCRPMT 323
Query: 333 ARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMNQRRVDFYL 392
RS VAV+ G ++ GG G + + Y+P W +V SMN +R
Sbjct: 324 TARSRVGVAVVNGLLYAIGG-----YDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGT 378
Query: 393 ASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDFVYISGGH 452
++ + GG + N +LSSVETYSP+TD W+ V + T+++ +Y+SGGH
Sbjct: 379 VVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGH 438
Query: 453 D-YQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDNIESMERF 511
D QI ++ Y+H T W M R H SLG ++ GG D +
Sbjct: 439 DGLQI---FSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGS------- 488
Query: 512 DVLGV-EAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQVYDR 570
L + E YS +QW + P+ S + GR+Y +GGY ++ S V++YD
Sbjct: 489 GFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSS--VEMYDP 546
Query: 571 EADKWS 576
E D W+
Sbjct: 547 ETDCWT 552
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/105 (35%), Positives = 51/105 (48%), Gaps = 9/105 (8%)
Query: 475 ERRPMTTARGWHSMC--SLGDSIYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPL 532
ERRP A C S+ IY++GG + +S+ VE + P N W R P+
Sbjct: 268 ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNV-----VEVFDPIANCWERCRPM 322
Query: 533 LHANSESGVAVWEGRIYILGGYSWENTAFSKTVQVYDREADKWSR 577
A S GVAV G +Y +GGY + TV+ Y+ E D W+R
Sbjct: 323 TTARSRVGVAVVNGLLYAIGGYDGQLRL--STVEAYNPETDTWTR 365
Score = 54.3 bits (129), Expect = 3e-07
Identities = 32/104 (30%), Positives = 47/104 (45%), Gaps = 5/104 (4%)
Query: 325 WVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMN 384
W + +R H A LG +F+ GG G ++ Y QW + M+
Sbjct: 457 WHPAAGMLNKRCRHGAASLGSKMFVCGGY-----DGSGFLSIAEMYSSVADQWCLIVPMH 511
Query: 385 QRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVA 428
RR L + L A+GG + LSSVE Y P+TD W+++A
Sbjct: 512 TRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMA 555
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 209 bits (531), Expect = 8e-54
Identities = 158/574 (27%), Positives = 256/574 (44%), Gaps = 27/574 (4%)
Query: 25 WADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQ 84
W D ++L+ G CDV L + + H+ +LA YF +MF M EA Q
Sbjct: 50 WKDFHGSLLRFYEN----GELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQ 105
Query: 85 KEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVS 144
+E+ ++ +V F+Y L L N+ +L A +LQ+ V CCEY++
Sbjct: 106 TLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFH 165
Query: 145 EDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQR 204
N L ++ A ++ L D + +HF + DF+ +VS Q L LSSS++
Sbjct: 166 PSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFV-SVSPQHLHKLLSSSDLNI 224
Query: 205 ECEHDLLQAALQWLTQQPEREAH-ARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANC 263
E E + AA++WL P+ + + L + PL+P + L+ V A ++ + C
Sbjct: 225 ENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVV--AKEQIVKQNLKC 282
Query: 264 EGFIEEAVRYHNNLAAQPVMQTK---RTALRTNQERLLFVGGEVSERCLELSDDTCYLDA 320
++EA YH +L+++ V + RT R + +LF G CY
Sbjct: 283 RDLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECY-SI 341
Query: 321 KSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKV 380
W + +RR H V + G ++ GG ++ G + +DP +W+
Sbjct: 342 NKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGS-----MEMFDPLTNKWMMK 396
Query: 381 ASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGT 440
ASMN +R LAS+ + AIGG ++N + VE Y ++D WS VA + G
Sbjct: 397 ASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSV 456
Query: 441 IYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGG 500
+ VY GG+D ++ YD D W E + M R + + L +Y +GG
Sbjct: 457 ALVNHVYAVGGNDGMAS--LSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGG 514
Query: 501 SDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTA 560
DDN + VE Y P+ N+W VA L G+A G+I+ +GG++ A
Sbjct: 515 FDDN------SPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHN--GNA 566
Query: 561 FSKTVQVYDREADKWSRGVDLPKAIAGGSACVCA 594
+ TV+ +D ++W + AG VC+
Sbjct: 567 YLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCS 600
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 202 bits (515), Expect = 6e-52
Identities = 156/581 (26%), Positives = 272/581 (46%), Gaps = 36/581 (6%)
Query: 2 MEGSRQTRVSRPYKISESSKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHR 61
MEG+ Q + ++ +SK H ++ R RGL CD+VL + + AH+
Sbjct: 53 MEGAVQLLSREGHSVAHNSK-----RHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHK 107
Query: 62 NLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLE 121
+LA CS YF++MFT M E+ Q V L L +V F Y E+V+ GN+ +L
Sbjct: 108 VVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLP 167
Query: 122 TAHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFT 181
A LLQ+ V D CC++L ++ N L ++ A +S L ++L HF ++ T
Sbjct: 168 AASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKT 227
Query: 182 PDFLQNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPE-REAHARQVLENIHFPLI 240
+F+ + ++++ +SS + E ++ +A L W+ + R H ++++ + PL+
Sbjct: 228 EEFML-LPLKQVLELVSSDSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLL 286
Query: 241 PKNDLLHRVKPAVCSLLPKEANCEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQER---L 297
++ LL V SL+ +C+ + EA+++H + V+ T RT R + L
Sbjct: 287 SRDFLLGHVDAE--SLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVL 344
Query: 298 LFVGGEVSERCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRD 357
VGG + D D ++++W + RR+ VA +G ++ GG D
Sbjct: 345 FAVGG---GSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGG---YD 398
Query: 358 NGGDAASNLLYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETY 417
D A+ + YDP W SM RR +A++ +L + GG + L+S E Y
Sbjct: 399 GTSDLAT--VESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERY 456
Query: 418 SPKTDSWSYVAGL-PRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEER 476
P T +W+ VA + R Y T+ + +Y GG+D + + Y+ + +VW
Sbjct: 457 DPLTGTWTSVAAMSTRRRYVRVATLDGN-LYAVGGYD--SSSHLATVEKYEPQVNVWSPV 513
Query: 477 RPMTTARGWHSMCSLGDSIYSIGGSDDN--IESMERFDVLGVEAYSPQCNQWTRVAPLLH 534
M + R + L ++Y GG+D + S+ER YSP+ W VAP+
Sbjct: 514 ASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVER--------YSPKAGAWESVAPMNI 565
Query: 535 ANSESGVAVWEGRIYILGGYSWENTAFSKTVQVYDREADKW 575
S + +G +Y +GG + ++ +++ Y+ +KW
Sbjct: 566 RRSTHDLVAMDGWLYAVGGN--DGSSSLNSIEKYNPRTNKW 604
Score = 46.6 bits (109), Expect = 7e-05
Identities = 27/100 (27%), Positives = 45/100 (45%), Gaps = 8/100 (8%)
Query: 297 LLFVGGEVSERCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSR 356
L GG CL + K+ W P+ RRS H + + G+++ GG
Sbjct: 532 LYVAGGNDGTSCLNSVER---YSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGG---- 584
Query: 357 DNGGDAASNLLYRYDPRCKQWIKVASMNQRRVDFYLASIE 396
N G ++ N + +Y+PR +W+ + M RR +A +E
Sbjct: 585 -NDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLE 623
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 200 bits (509), Expect = 3e-51
Identities = 135/502 (26%), Positives = 243/502 (48%), Gaps = 23/502 (4%)
Query: 79 MREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEY 138
M E+ K V + L+ ++D++Y E+ + N+ +L A LLQ+ V CCE+
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 139 LEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLS 198
LE ++ N L ++ A +++ L + + HF + + +FL N+ ++++C +S
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFL-NLGIEQVCSLIS 119
Query: 199 SSEVQRECEHDLLQAALQWLTQQPE-REAHARQVLENIHFPLIPKNDLLHRVKPAVCSLL 257
S ++ E + +A + W+ + R+ +++E++ PL+P+ L+ RV+ +L+
Sbjct: 120 SDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEE--ALV 177
Query: 258 PKEANCEGFIEEAVRYHNNLAAQPV-MQTKRTALRT--NQERLLFVGGEVSERCLELSDD 314
+ C+ ++ EA++YH Q + M++ RT LRT N +L+ V G + + + +
Sbjct: 178 KNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVE- 236
Query: 315 TCYLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRC 374
CY D K E+W + LP+RR + + G +F GG G + YDP
Sbjct: 237 -CY-DFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGF-----NGSLRVRTVDSYDPVK 289
Query: 375 KQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFT 434
QW VA+M RR A + +L A+GG + + LSSVE Y+ K++ W +VA +
Sbjct: 290 DQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRR 349
Query: 435 YGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDS 494
+ +Y GG+D + CY+ T+ W M+T R + L +
Sbjct: 350 SSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNL 409
Query: 495 IYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGY 554
+Y++GG D + VE Y P N W +VA + +GV G +Y++GG
Sbjct: 410 LYAVGGHDGPLVRK------SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD 463
Query: 555 SWENTAFSKTVQVYDREADKWS 576
+ + +V+ Y+ DKW+
Sbjct: 464 --DGSCNLASVEYYNPTTDKWT 483
Score = 64.7 bits (156), Expect = 2e-10
Identities = 45/150 (30%), Positives = 69/150 (46%), Gaps = 10/150 (6%)
Query: 297 LLFVGGE--VSERCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSF 354
L VGG S +CL + CY +A + +W + RRS V VL ++ GG
Sbjct: 361 LYAVGGYDGASRQCLSTVE--CY-NATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG-- 415
Query: 355 SRDNGGDAASNLLYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSV 414
+ G + YDP W +VA MN R + + ++ +L +GG + + L+SV
Sbjct: 416 ---HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASV 472
Query: 415 ETYSPKTDSWSYVAGLPRFTYGHAGTIYKD 444
E Y+P TD W+ V+ +AG D
Sbjct: 473 EYYNPTTDKWTVVSSCMSTGRSYAGVTVID 502
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 199 bits (507), Expect = 5e-51
Identities = 161/590 (27%), Positives = 258/590 (43%), Gaps = 46/590 (7%)
Query: 23 YRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPA-----HRNLLAVCSDYFNSMFTI 77
Y DH+ +NE RL CDV L Q PA H+ +LA S F +MFT
Sbjct: 54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
Query: 78 GMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCE 137
G+RE + V + G ++ +++F Y + + + +V+ A + QI +VV C +
Sbjct: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
Query: 138 YLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYL 197
+L Q++ N + + A L +I HFG ++ +F N+S +L +
Sbjct: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFF-NLSHCQLVTLI 232
Query: 198 SSSEVQRECEHDLLQAALQWLTQQPE-REAHARQVLENIHFPLIPKNDLLHRVKPAVCSL 256
S ++ CE ++ A + W+ E R + + +L + + N L +++ C +
Sbjct: 233 SRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQK--CEI 290
Query: 257 LPKEANCEGF---IEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSD 313
L ++ C+ + I E + H P K RL++ G + L
Sbjct: 291 LQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPK-------VGRLIYTAGGYFRQSLS--- 340
Query: 314 DTCYLDAKSEQ---WVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRY 370
YL+A + W++ L RS V+GG ++ GG + G+ S+ L Y
Sbjct: 341 ---YLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGR-NNSPDGNTDSSALDCY 396
Query: 371 DPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGL 430
+P QW A M+ R + I+ + A+GG + +SVE Y P+ D W VA +
Sbjct: 397 NPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPM 456
Query: 431 PRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLL-CYDHRTDVWEERRPMTTARGWHSMC 489
G + +Y GG D G R N CY + W M T R +C
Sbjct: 457 LTRRIGVGVAVLNRLLYAVGGFD---GTNRLNSAECYYPERNEWRMITAMNTIRSGAGVC 513
Query: 490 SLGDSIYSIGGSD--DNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGR 547
L + IY+ GG D D + S+ER+DV + WT VAP+ H S G+ V +GR
Sbjct: 514 VLHNCIYAAGGYDGQDQLNSVERYDV--------ETETWTFVAPMKHRRSALGITVHQGR 565
Query: 548 IYILGGYSWENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVCALEP 597
IY+LGGY + F +V+ YD + D WS + +G V +EP
Sbjct: 566 IYVLGGY--DGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAV-TMEP 612
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 199 bits (507), Expect = 5e-51
Identities = 161/590 (27%), Positives = 258/590 (43%), Gaps = 46/590 (7%)
Query: 23 YRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPA-----HRNLLAVCSDYFNSMFTI 77
Y DH+ +NE RL CDV L Q PA H+ +LA S F +MFT
Sbjct: 54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
Query: 78 GMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCE 137
G+RE + V + G ++ +++F Y + + + +V+ A + QI +VV C +
Sbjct: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
Query: 138 YLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYL 197
+L Q++ N + + A L +I HFG ++ +F N+S +L +
Sbjct: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFF-NLSHCQLVTLI 232
Query: 198 SSSEVQRECEHDLLQAALQWLTQQPE-REAHARQVLENIHFPLIPKNDLLHRVKPAVCSL 256
S ++ CE ++ A + W+ E R + + +L + + N L +++ C +
Sbjct: 233 SRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQK--CEI 290
Query: 257 LPKEANCEGF---IEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSD 313
L ++ C+ + I E + H P K RL++ G + L
Sbjct: 291 LQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPK-------VGRLIYTAGGYFRQSLS--- 340
Query: 314 DTCYLDAKSEQ---WVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRY 370
YL+A + W++ L RS V+GG ++ GG + G+ S+ L Y
Sbjct: 341 ---YLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGR-NNSPDGNTDSSALDCY 396
Query: 371 DPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGL 430
+P QW A M+ R + I+ + A+GG + +SVE Y P+ D W VA +
Sbjct: 397 NPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPM 456
Query: 431 PRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLL-CYDHRTDVWEERRPMTTARGWHSMC 489
G + +Y GG D G R N CY + W M T R +C
Sbjct: 457 LTRRIGVGVAVLNRLLYAVGGFD---GTNRLNSAECYYPERNEWRMITAMNTIRSGAGVC 513
Query: 490 SLGDSIYSIGGSD--DNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGR 547
L + IY+ GG D D + S+ER+DV + WT VAP+ H S G+ V +GR
Sbjct: 514 VLHNCIYAAGGYDGQDQLNSVERYDV--------ETETWTFVAPMKHRRSALGITVHQGR 565
Query: 548 IYILGGYSWENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVCALEP 597
IY+LGGY + F +V+ YD + D WS + +G V +EP
Sbjct: 566 IYVLGGY--DGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAV-TMEP 612
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 199 bits (507), Expect = 5e-51
Identities = 155/600 (25%), Positives = 275/600 (45%), Gaps = 38/600 (6%)
Query: 8 TRVSRPYKISESSKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVC 67
T+ S + S + + +H+ L+++ CDV+L+A R+PAHR +L+
Sbjct: 144 TQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAV 203
Query: 68 SDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQ 127
SDYF +MFT + EA Q+EV + G L ++V + Y G L L I+ +L A LLQ
Sbjct: 204 SDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQ 263
Query: 128 IWTVVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQN 187
+ V+D C +L +++ N L ++ L + + HF + +FL
Sbjct: 264 LTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLL- 322
Query: 188 VSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPE-REAHARQVLENIHFPLIPKNDLL 246
+ ++ L S ++ E + A +QW+ + R+ +L I PL+P LL
Sbjct: 323 LPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPP-QLL 381
Query: 247 HRVKPAVCSLLPKEANCEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSE 306
++ + S+ + C+ + EA++YH + +MQ+ RT R + L+ G +
Sbjct: 382 ADLETS--SMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMD- 438
Query: 307 RCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNL 366
++ + D ++ W+ + RR VAV+ +++ GG RD G N
Sbjct: 439 -AMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGG---RD--GLKTLNT 492
Query: 367 LYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSY 426
+ ++P K W + M+ R +A++E + A+GG + L++VE + P+ W+Y
Sbjct: 493 VECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNY 552
Query: 427 VAGL--PRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARG 484
VA + PR T G K +Y GG D K++ +D T+ W PM+ RG
Sbjct: 553 VASMSTPRSTVGVVALNNK--LYAIGGRDG--SSCLKSMEYFDPHTNKWSLCAPMSKRRG 608
Query: 485 WHSMCSLGDSIYSIGGSDDNI--------ESMERFDVLGVEAYSPQCNQWTRVAPLLHAN 536
+ + +Y +GG D + +ER+D P+ + W+ VAPL
Sbjct: 609 GVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYD--------PKGDSWSTVAPLSVPR 660
Query: 537 SESGVAVWEGRIYILGGYSWENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVCALE 596
V ++Y++GGY + + TV+ YD + ++W ++P I ACV ++
Sbjct: 661 DAVAVCPLGDKLYVVGGY--DGHTYLNTVESYDAQRNEWKE--EVPVNIGRAGACVVVVK 716
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 198 bits (504), Expect = 1e-50
Identities = 154/569 (27%), Positives = 252/569 (44%), Gaps = 71/569 (12%)
Query: 17 SESSKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFT 76
S S + Y+ H+ +++ + CDV+L+ +++PAHR +L+ SDYF +MFT
Sbjct: 183 SSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFT 242
Query: 77 IGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCC 136
+ EA Q+E+++ G L +V F Y G L L I+ +L A LLQ+ VV+ CC
Sbjct: 243 SDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCC 302
Query: 137 EYLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVY 196
+L + + N L ++ A L + + + + +FL + ++L
Sbjct: 303 HFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLL-LPAEELHKL 361
Query: 197 LSSSEVQRECEHDLLQAALQWLTQQPEREAH-ARQVLENIHFPLIPKNDLLHRVKPAVCS 255
L+S +V E + A + W+ + + +L I PL+P L A
Sbjct: 362 LASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLENHA--- 418
Query: 256 LLPKEANCEGFIEEAVRYHNNLAAQPVMQTKRTA-------------------------- 289
L + C+ I EA++YH + +MQ+ RT
Sbjct: 419 LFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEK 478
Query: 290 --LRTN--------------------QERLLFVGGEVSERCLELSDDTCYLDAKSEQWVK 327
LRTN ++L +GG + L + CY + K++ W
Sbjct: 479 YDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVE--CY-NPKTKTWTV 535
Query: 328 ETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMNQRR 387
P+ R V VL G I+ GG + G + N + R+DP+ +QW VASM+ R
Sbjct: 536 LPPMSTHRHGLGVTVLEGPIYAVGG-----HDGWSYLNTVERWDPQSQQWTFVASMSIAR 590
Query: 388 VDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDFVY 447
+A++ L ++GGR+ + LSS+E Y P T+ W+ A + + G F+Y
Sbjct: 591 STVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLY 650
Query: 448 ISGGHDYQIGPYRKNLL----CYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDD 503
GGHD + LL YD +TD W P++ R +C LGD +Y++GG D
Sbjct: 651 AVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDG 710
Query: 504 NIESMERFDVLGVEAYSPQCNQWTRVAPL 532
+ +E+Y PQ N+WT++A L
Sbjct: 711 QTY------LNTMESYDPQTNEWTQMASL 733
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 197 bits (502), Expect = 2e-50
Identities = 150/540 (27%), Positives = 255/540 (47%), Gaps = 24/540 (4%)
Query: 61 RNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVL 120
R +L+ SDYF +MFT +REA Q+E+++ G L +++ + Y G L L NI+ +L
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 121 ETAHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSF 180
TA LLQ+ VV+ CC++L +++ N L ++ A L + + HF +
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 181 TPDFLQNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPE-REAHARQVLENIHFPL 239
+F+ + ++ L+S ++ E +L A L W+ E R ++L I PL
Sbjct: 294 NQEFVL-LPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPL 352
Query: 240 IPKNDLLHRVKPAVCSLLPKEANCEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLF 299
+ L L + C+ I EA++YH +P++Q+ RT R + LF
Sbjct: 353 LAPQFLADMENNV---LFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLF 409
Query: 300 -VGGEVSERCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDN 358
VGG S + + D ++ W + RR VAVL +++ GG RD
Sbjct: 410 AVGGMDSTKGATSIEK---YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG---RD- 462
Query: 359 GGDAASNLLYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYS 418
G N + Y+P+ K W + M+ R +A +E + A+GG + L++VE +
Sbjct: 463 -GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWD 521
Query: 419 PKTDSWSYVAGL--PRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEER 476
P+ W++VA + PR T G A + +Y GG D K++ C+D T+ W
Sbjct: 522 PQARQWNFVATMSTPRSTVGVA--VLSGKLYAVGGRDG--SSCLKSVECFDPHTNKWTLC 577
Query: 477 RPMTTARGWHSMCSLGDSIYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHAN 536
M+ RG + + +Y+IGG D ++ VE Y P+ + WT VA + +
Sbjct: 578 AQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISR 637
Query: 537 SESGVAVWEGRIYILGGYSWENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVCALE 596
GV + ++Y +GGY + A+ TV+ YD + ++W++ P + ACV ++
Sbjct: 638 DAVGVCLLGDKLYAVGGY--DGQAYLNTVEAYDPQTNEWTQVA--PLCLGRAGACVVTVK 693
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 195 bits (495), Expect = 1e-49
Identities = 150/583 (25%), Positives = 267/583 (45%), Gaps = 36/583 (6%)
Query: 8 TRVSRPYKISESSKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVC 67
T+ S + S + + +H+ L+++ CDV+L+A R+PAHR +L+
Sbjct: 144 TQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAV 203
Query: 68 SDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQ 127
SDYF +MFT + EA Q+EV + G L ++V + Y G L L I+ +L A LLQ
Sbjct: 204 SDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQ 263
Query: 128 IWTVVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQN 187
+ V+D C +L +++ N L ++ L + + HF + +FL
Sbjct: 264 LTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLL- 322
Query: 188 VSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPE-REAHARQVLENIHFPLIPKNDLL 246
+ ++ L S ++ E + A +QW+ + R+ +L I PL+P LL
Sbjct: 323 LPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPP-QLL 381
Query: 247 HRVKPAVCSLLPKEANCEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSE 306
++ + S+ + C+ + EA++YH + +MQ+ RT R + L+ G +
Sbjct: 382 ADLETS--SMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMD- 438
Query: 307 RCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNL 366
++ + D ++ W+ + RR VAV+ +++ GG RD G N
Sbjct: 439 -AMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGG---RD--GLKTLNT 492
Query: 367 LYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSY 426
+ ++P K W + M+ R +A++E + A+GG + L++VE + P+ W+Y
Sbjct: 493 VECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNY 552
Query: 427 VAGL--PRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARG 484
VA + PR T G K +Y GG D K++ +D T+ W PM+ RG
Sbjct: 553 VASMSTPRSTVGVVALNNK--LYAIGGRDG--SSCLKSMEYFDPHTNKWSLCAPMSKRRG 608
Query: 485 WHSMCSLGDSIYSIGGSDDNI--------ESMERFDVLGVEAYSPQCNQWTRVAPLLHAN 536
+ + +Y +GG D + +ER+D P+ + W+ VAPL
Sbjct: 609 GVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYD--------PKGDSWSTVAPLSVPR 660
Query: 537 SESGVAVWEGRIYILGGYSWENTAFSKTVQVYDREADKWSRGV 579
V ++Y++GGY + + TV+ YD + ++W +
Sbjct: 661 DAVAVCPLGDKLYVVGGY--DGHTYLNTVESYDAQRNEWKESM 701
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 194 bits (494), Expect = 2e-49
Identities = 151/570 (26%), Positives = 249/570 (43%), Gaps = 25/570 (4%)
Query: 28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEV 87
H+ ++L +N R CDV L +++ PAHR +LA CSDYF +MFT + E + V
Sbjct: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
Query: 88 ELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
++ G + ++ ++DF+Y + + N+ +L A LLQ+ V CCE+LE ++ N
Sbjct: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
Query: 148 YLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECE 207
L +++ A ++ L + F HF + +F+ +S ++ + E+Q + E
Sbjct: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFIL-LSQGEVEKLIKCDEIQVDSE 193
Query: 208 HDLLQAALQWLTQ-QPEREAHARQVLENIHFPLIPK---NDLLHRVKPAVCSLLPKEANC 263
+ +A + W+ + ERE +L+ + PL+ D++ CSL C
Sbjct: 194 EPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSL-----QC 248
Query: 264 EGFIEEAVRYHNNLAAQPVMQTKRTALRTN-QERLLFVGGEVSERCLELSDDTCYLDAKS 322
++EA ++H + MQ RT R E LL VGG S++ D D K+
Sbjct: 249 RDLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQ--SPIDVVEKYDPKT 306
Query: 323 EQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVAS 382
++W + +R + L I++ GG R + L Y D W VA
Sbjct: 307 QEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSR-LSSVECLDYTAD-EDGVWYSVAP 364
Query: 383 MNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIY 442
MN RR ++ DM+ GG + + +S+E Y P D WS + + G +
Sbjct: 365 MNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVA 424
Query: 443 KDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSD 502
+Y GG+D ++ YD T W PM T R + L D IY +GG D
Sbjct: 425 SGVIYCLGGYDGL--NILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFD 482
Query: 503 DNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFS 562
+ VEAY+ + + WT V + G V GR+Y + GY + +
Sbjct: 483 GTAH------LSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGY--DGNSLL 534
Query: 563 KTVQVYDREADKWSRGVDLPKAIAGGSACV 592
+++ YD D W + CV
Sbjct: 535 SSIECYDPIIDSWEVVTSMGTQRCDAGVCV 564
Score = 67.4 bits (163), Expect = 4e-11
Identities = 51/175 (29%), Positives = 74/175 (42%), Gaps = 11/175 (6%)
Query: 319 DAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWI 378
D +QW + R + V G I+ GG G N + +YDP W
Sbjct: 400 DPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGY-----DGLNILNSVEKYDPHTGHWT 454
Query: 379 KVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGL--PRFTYG 436
V M +R +A + D + +GG + LSSVE Y+ +TDSW+ V + PR G
Sbjct: 455 NVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVG 514
Query: 437 HAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSL 491
T+ + +Y G+D ++ CYD D WE M T R +C L
Sbjct: 515 --ATVLRGRLYAIAGYDGN--SLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVL 565
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 191 bits (486), Expect = 1e-48
Identities = 148/567 (26%), Positives = 259/567 (45%), Gaps = 36/567 (6%)
Query: 28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEV 87
H+ +L ++N+ R FCDV L ++ AHR +LA S YF ++FT GM+E+ + V
Sbjct: 19 HAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVV 78
Query: 88 ELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
++G + ++DF+Y G + + N+ ++ A +LQ+ VV CCE+L+ ++ N
Sbjct: 79 PILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLN 138
Query: 148 YLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECE 207
+ + + + + L F + +I HF + +FL ++ +L L S E+ E E
Sbjct: 139 CIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLA-LTKDQLIKILRSEELSIEDE 197
Query: 208 HDLLQAALQWLTQQ-PEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGF 266
+ + AA+QW+ + +R H +VL+ I FPL+P LL ++ + N
Sbjct: 198 YQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGV------SDFNLRVA 251
Query: 267 IEEAVRYHNNLAAQP-------VMQTKRTALRTNQERLLF-VGGEVSERCLELSDDTCY- 317
++ ++ + + P +QT + R + L+ VGG + SD
Sbjct: 252 LQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALS 311
Query: 318 ----LDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPR 373
D S+ W + L RS V VLGG ++ GG +D+ + YDP
Sbjct: 312 CVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGG--EKDS---MIFDCTECYDPV 366
Query: 374 CKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRF 433
KQW VASMN R + + A+GG +++E + P + W V +
Sbjct: 367 TKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVS 426
Query: 434 TYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGD 493
Y + +Y+ GG + G ++ YD + W PM T R + + +L D
Sbjct: 427 RYYFGCCEMQGLIYVIGGISNE-GIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALND 485
Query: 494 SIYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGG 553
IYS+GG ++ +++ VE YS + +W VA + + V G +Y+ GG
Sbjct: 486 CIYSVGGWNETQDALHT-----VEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
Query: 554 YSWENTAFS----KTVQVYDREADKWS 576
S + + +V+VY+ +D W+
Sbjct: 541 RSSSHDFLAPGTLDSVEVYNPHSDTWT 567
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 191 bits (486), Expect = 1e-48
Identities = 144/571 (25%), Positives = 263/571 (46%), Gaps = 28/571 (4%)
Query: 29 SSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVE 88
S+ + NE RL G CDVV+ + AH+N+L CS YF ++FT G +K
Sbjct: 22 SAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYN 81
Query: 89 LIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNY 148
+ G S +K ++++ Y + + N++ +L A I +V CCE+L+ E+ DN
Sbjct: 82 IPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNC 141
Query: 149 LYLQELASIYSLKRLDAFIDGFILNHFGTL-SFTPDFLQNVSMQKLCVYLSSSEVQRECE 207
+ + + Y L FIL++F + + +FL+ +S+ +L + E+ + E
Sbjct: 142 IGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLE-LSVTELKDIIEKDELNVKQE 200
Query: 208 HDLLQAALQWLTQQPE-REAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGF 266
+ +A L+W++ P+ R+ H +L + L+ ++ VK + + C+
Sbjct: 201 DAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVK--MNDYVKDSEECKPV 258
Query: 267 IEEAVR----YHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCYLDAKS 322
I A++ + N + T R L +GG + DA++
Sbjct: 259 IINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIE---AYDARA 315
Query: 323 EQWVKET-PLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVA 381
++WV T + R++H A L G+++I GG S D N + R+DP K W +VA
Sbjct: 316 DRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVD-----YFNSVKRFDPVKKTWHQVA 370
Query: 382 SMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTI 441
M+ RR + + + + A+GG + L++ E Y P+T+ W+ +A + + T
Sbjct: 371 PMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATT 430
Query: 442 YKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGS 501
VYI GG + + + Y+ ++ W PM + R + + G+ +Y++GG
Sbjct: 431 LYGKVYICGGFNGNECLFTAEV--YNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGF 488
Query: 502 DDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAF 561
D + EAYSP N W + + + S G+ V + ++++GG++ T F
Sbjct: 489 DGANR------LRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTF 542
Query: 562 SKTVQVYDREADKWSRGVDLPKAIAGGSACV 592
+ V+ YD + D+W D+ + S CV
Sbjct: 543 N--VECYDEKTDEWYDAHDMSIYRSALSCCV 571
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 189 bits (479), Expect = 8e-48
Identities = 156/551 (28%), Positives = 251/551 (45%), Gaps = 37/551 (6%)
Query: 26 ADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQK 85
+ H+ +LQ NE R LF DV++ + + P HR +L+ CS YF +MF RE+ +
Sbjct: 46 SSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREM 105
Query: 86 EVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSE 145
VE+ G ++ + ++Y G++ + N+ Y+ ET+ L QI + D C ++LE+++
Sbjct: 106 LVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDP 165
Query: 146 DNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRE 205
N L +Q A +SLK L F L F +S +FL+ + +L Y+ S E+
Sbjct: 166 CNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLE-LDKDELIDYICSDELVIG 224
Query: 206 CEHDLLQAALQWLTQQPE-REAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCE 264
E + +A ++W+ + + R ++L ++ PL+ N + V+ V L+ C
Sbjct: 225 KEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVE--VDQLIQNSPECY 282
Query: 265 GFIEEAVRYH--NNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCYLDAKS 322
+ EA RYH N P + +R+ E ++ VGG L CY D +
Sbjct: 283 QLLHEARRYHILGNEMMSPRTRPRRST--GYSEVIVVVGGCERVGGFNLPYTECY-DPVT 339
Query: 323 EQWVKETPLPA-RRSHHCVAVLGGFIFIAGGSF-SRDNGGDAASNLLYRYDPRCKQWIKV 380
+W LP +S + V L I ++GG SRD ++ Y+ + WI+V
Sbjct: 340 GEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRD---------VWIYNSQLNIWIRV 390
Query: 381 ASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGT 440
AS+N+ R +A + + +GG + LSSVE Y ++ W+ VA L A T
Sbjct: 391 ASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVT 450
Query: 441 --IYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSI 498
+ K FV I GG D + YD T+ W R + A+ + SL + IY
Sbjct: 451 SCVGKLFV-IGGGPD--DNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVA 507
Query: 499 GGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWEN 558
GG + Y P + W V G++V G+IYILGG EN
Sbjct: 508 GGL-----------TKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRR-EN 555
Query: 559 TAFSKTVQVYD 569
+ T+ YD
Sbjct: 556 GEATDTILCYD 566
Score = 58.9 bits (141), Expect = 1e-08
Identities = 43/158 (27%), Positives = 73/158 (46%), Gaps = 18/158 (11%)
Query: 440 TIYKDFVYISGGHDYQIG---PYRKNLLCYDHRTDVWEERRPMTT-ARGWHSMCSLGDSI 495
T Y + + + GG + G PY + CYD T W+ + + +++C+L + I
Sbjct: 309 TGYSEVIVVVGGCERVGGFNLPYTE---CYDPVTGEWKSLAKLPEFTKSEYAVCALRNDI 365
Query: 496 YSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYS 555
GG R + V Y+ Q N W RVA L +AV G++Y++GGY
Sbjct: 366 LVSGG---------RINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYD 416
Query: 556 WENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVC 593
+N S V+ YD +++W+ L +A++ + C
Sbjct: 417 GQNRLSS--VECYDSFSNRWTEVAPLKEAVSSPAVTSC 452
Score = 49.3 bits (116), Expect = 1e-05
Identities = 40/150 (26%), Positives = 64/150 (42%), Gaps = 17/150 (11%)
Query: 298 LFV--GGEVSERCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFS 355
LFV GG C SD D ++ W+ +P + L I++AGG
Sbjct: 456 LFVIGGGPDDNTC---SDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG--- 509
Query: 356 RDNGGDAASNLLYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENG-ALSSV 414
+ +Y YDP W+ V + R+ + ++ + +GGR ENG A ++
Sbjct: 510 -------LTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTI 562
Query: 415 ETYSPKTDSWSYVAGLPR-FTYGHAGTIYK 443
Y P T + VA +PR +Y TI++
Sbjct: 563 LCYDPATSIITGVAAMPRPVSYHGCVTIHR 592
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,093,370
Number of Sequences: 37866
Number of extensions: 1076047
Number of successful extensions: 4068
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 161
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 2593
Number of HSP's gapped (non-prelim): 354
length of query: 616
length of database: 18,247,518
effective HSP length: 108
effective length of query: 508
effective length of database: 14,157,990
effective search space: 7192258920
effective search space used: 7192258920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.