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Search of human proteins with 27544933
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27544933 solute carrier family 25, member 16 [Homo sapiens]
(332 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27544933 solute carrier family 25, member 16 [Homo sapiens] 677 0.0
gi|60460887 solute carrier family 25, member 42 [Homo sapiens] 198 6e-51
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ... 182 3e-46
gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s... 182 3e-46
gi|48476342 solute carrier family 25, member 23 [Homo sapiens] 172 4e-43
gi|239755176 PREDICTED: similar to solute carrier family 25, mem... 171 6e-43
gi|239755174 PREDICTED: similar to solute carrier family 25, mem... 171 6e-43
gi|56699407 solute carrier family 25, member 25 isoform c [Homo ... 171 6e-43
gi|56699401 solute carrier family 25, member 25 isoform a [Homo ... 171 6e-43
gi|56699405 solute carrier family 25, member 25 isoform d [Homo ... 171 6e-43
gi|56699403 solute carrier family 25, member 25 isoform b [Homo ... 171 6e-43
gi|21687151 mitochondrial solute carrier protein [Homo sapiens] 140 2e-33
gi|186928856 solute carrier family 25, member 19 [Homo sapiens] 126 2e-29
gi|186928860 solute carrier family 25, member 19 [Homo sapiens] 126 2e-29
gi|186928858 solute carrier family 25, member 19 [Homo sapiens] 126 2e-29
gi|13775208 solute carrier family 25 (mitochondrial carrier; ade... 125 7e-29
gi|149274607 solute carrier family 25, member 41 [Homo sapiens] 124 1e-28
gi|55749577 solute carrier family 25 (mitochondrial carrier; ade... 111 8e-25
gi|156071462 solute carrier family 25, member A6 [Homo sapiens] 110 2e-24
gi|156071459 solute carrier family 25, member 5 [Homo sapiens] 105 4e-23
gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens] 102 6e-22
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s... 96 3e-20
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo... 96 3e-20
gi|157388925 solute carrier family 25, member 38 [Homo sapiens] 95 1e-19
gi|21361103 solute carrier family 25, member 12 [Homo sapiens] 92 6e-19
gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho... 90 2e-18
gi|13259543 solute carrier family 25, member 14 isoform UCP5S [H... 90 2e-18
gi|86198310 solute carrier family 25, member 29 [Homo sapiens] 90 3e-18
gi|157388989 solute carrier family 25, member 36 isoform a [Homo... 89 5e-18
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit... 88 9e-18
>gi|27544933 solute carrier family 25, member 16 [Homo sapiens]
Length = 332
Score = 677 bits (1747), Expect = 0.0
Identities = 332/332 (100%), Positives = 332/332 (100%)
Query: 1 MAAATAAAALAAADPPPAMPQAAGAGGPTTRRDFYWLRSFLAGGIAGCCAKTTVAPLDRV 60
MAAATAAAALAAADPPPAMPQAAGAGGPTTRRDFYWLRSFLAGGIAGCCAKTTVAPLDRV
Sbjct: 1 MAAATAAAALAAADPPPAMPQAAGAGGPTTRRDFYWLRSFLAGGIAGCCAKTTVAPLDRV 60
Query: 61 KVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTL 120
KVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTL
Sbjct: 61 KVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTL 120
Query: 121 ITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHSYTGIIHAFKTIYA 180
ITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHSYTGIIHAFKTIYA
Sbjct: 121 ITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHSYTGIIHAFKTIYA 180
Query: 181 KEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKT 240
KEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKT
Sbjct: 181 KEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKT 240
Query: 241 HVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGL 300
HVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGL
Sbjct: 241 HVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGL 300
Query: 301 YRGLSLNYIRCIPSQAVAFTTYELMKQFFHLN 332
YRGLSLNYIRCIPSQAVAFTTYELMKQFFHLN
Sbjct: 301 YRGLSLNYIRCIPSQAVAFTTYELMKQFFHLN 332
>gi|60460887 solute carrier family 25, member 42 [Homo sapiens]
Length = 318
Score = 198 bits (503), Expect = 6e-51
Identities = 117/294 (39%), Positives = 164/294 (55%), Gaps = 21/294 (7%)
Query: 37 LRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGN 96
L S L G +AG AKT VAPLDR K++ Q + + F L EGFL L++GN
Sbjct: 34 LSSLLPGALAGALAKTAVAPLDRTKIIFQVSSKRFSAKEAFRVLYYTYLNEGFLSLWRGN 93
Query: 97 GAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHV----HRLMAGSMAGMTAVICTYPLD 152
A M+R+ PY AIQF A E YK ++ + G G RL AG++AG TA TYPLD
Sbjct: 94 SATMVRVVPYAAIQFSAHEEYKRILGSYYGFRGEALPPWPRLFAGALAGTTAASLTYPLD 153
Query: 153 MVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGT 212
+VR R+A V + Y+ I H F I ++E G Y G MPT+LG+ PYAG+SFFT+ T
Sbjct: 154 LVRARMA--VTPKEMYSNIFHVFIRI-SREEGLKTLYHGFMPTVLGVIPYAGLSFFTYET 210
Query: 213 LKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQLGT 272
LKS+ ++ P ++ G AG I Q+ SYP DV RRRMQ
Sbjct: 211 LKSLHREYSGRRQPYPFE------------RMIFGACAGLIGQSASYPLDVVRRRMQTAG 258
Query: 273 VLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMK 326
V + + R T++ + G +GLY+GLS+N+++ + ++FTT++LM+
Sbjct: 259 V-TGYPRASIAR-TLRTIVREEGAVRGLYKGLSMNWVKGPIAVGISFTTFDLMQ 310
>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
sapiens]
Length = 477
Score = 182 bits (463), Expect = 3e-46
Identities = 107/292 (36%), Positives = 161/292 (55%), Gaps = 15/292 (5%)
Query: 36 WLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKG 95
W R LAGGIAG ++T+ APLDR+K+++Q H + +F R + ++ G L++G
Sbjct: 194 WWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRG 253
Query: 96 NGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMVR 155
NG +I+I P A++F A+E YK L+T + G R ++GSMAG TA YP+++++
Sbjct: 254 NGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMK 313
Query: 156 VRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKS 215
RLA G+ Y+GI K I K G FY+G +P +LG+ PYAG+ + LKS
Sbjct: 314 TRLAVGKTGQ--YSGIYDCAKKI-LKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKS 370
Query: 216 VGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLP 275
L + S NP V+VL L CG ++ Q SYP + R RMQ +L
Sbjct: 371 YWLDNF-----AKDSVNPGVMVL-----LGCGALSSTCGQLASYPLALVRTRMQAQAML- 419
Query: 276 EFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQ 327
E L M + + GI GLYRG++ N+++ +P+ +++ YE MKQ
Sbjct: 420 EGSPQLNMVGLFRRIISKEGI-PGLYRGITPNFMKVLPAVGISYVVYENMKQ 470
Score = 68.6 bits (166), Expect = 8e-12
Identities = 55/198 (27%), Positives = 89/198 (44%), Gaps = 23/198 (11%)
Query: 133 RLMAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHS-YTGIIHAFKTIYAKEGGFFGFYRG 191
+L+AG +AG + T PLD R+++ QV G S I F+ + KEGG +RG
Sbjct: 197 QLLAGGIAGAVSRTSTAPLD--RLKIMMQVHGSKSDKMNIFGGFRQM-VKEGGIRSLWRG 253
Query: 192 LMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAG 251
++ +AP V F+ + K + L+ +G T + G +AG
Sbjct: 254 NGTNVIKIAPETAVKFWAYEQYKKL-LTEEGQKIG-------------TFERFISGSMAG 299
Query: 252 AIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRC 311
A AQT YP +V + R+ +G + + D K + H G+ Y+G N +
Sbjct: 300 ATAQTFIYPMEVMKTRLAVGKT----GQYSGIYDCAKKILKHEGLG-AFYKGYVPNLLGI 354
Query: 312 IPSQAVAFTTYELMKQFF 329
IP + YEL+K ++
Sbjct: 355 IPYAGIDLAVYELLKSYW 372
>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
sapiens]
Length = 458
Score = 182 bits (463), Expect = 3e-46
Identities = 107/292 (36%), Positives = 161/292 (55%), Gaps = 15/292 (5%)
Query: 36 WLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKG 95
W R LAGGIAG ++T+ APLDR+K+++Q H + +F R + ++ G L++G
Sbjct: 175 WWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRG 234
Query: 96 NGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMVR 155
NG +I+I P A++F A+E YK L+T + G R ++GSMAG TA YP+++++
Sbjct: 235 NGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMK 294
Query: 156 VRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKS 215
RLA G+ Y+GI K I K G FY+G +P +LG+ PYAG+ + LKS
Sbjct: 295 TRLAVGKTGQ--YSGIYDCAKKI-LKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKS 351
Query: 216 VGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLP 275
L + S NP V+VL L CG ++ Q SYP + R RMQ +L
Sbjct: 352 YWLDNF-----AKDSVNPGVMVL-----LGCGALSSTCGQLASYPLALVRTRMQAQAML- 400
Query: 276 EFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQ 327
E L M + + GI GLYRG++ N+++ +P+ +++ YE MKQ
Sbjct: 401 EGSPQLNMVGLFRRIISKEGI-PGLYRGITPNFMKVLPAVGISYVVYENMKQ 451
Score = 68.6 bits (166), Expect = 8e-12
Identities = 55/198 (27%), Positives = 89/198 (44%), Gaps = 23/198 (11%)
Query: 133 RLMAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHS-YTGIIHAFKTIYAKEGGFFGFYRG 191
+L+AG +AG + T PLD R+++ QV G S I F+ + KEGG +RG
Sbjct: 178 QLLAGGIAGAVSRTSTAPLD--RLKIMMQVHGSKSDKMNIFGGFRQM-VKEGGIRSLWRG 234
Query: 192 LMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAG 251
++ +AP V F+ + K + L+ +G T + G +AG
Sbjct: 235 NGTNVIKIAPETAVKFWAYEQYKKL-LTEEGQKIG-------------TFERFISGSMAG 280
Query: 252 AIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRC 311
A AQT YP +V + R+ +G + + D K + H G+ Y+G N +
Sbjct: 281 ATAQTFIYPMEVMKTRLAVGKT----GQYSGIYDCAKKILKHEGLG-AFYKGYVPNLLGI 335
Query: 312 IPSQAVAFTTYELMKQFF 329
IP + YEL+K ++
Sbjct: 336 IPYAGIDLAVYELLKSYW 353
>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
Length = 468
Score = 172 bits (436), Expect = 4e-43
Identities = 100/292 (34%), Positives = 160/292 (54%), Gaps = 15/292 (5%)
Query: 36 WLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKG 95
W + +AG +AG ++T APLDR+KV +Q H L + LR++ + G L++G
Sbjct: 185 WWKQLVAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLNILGGLRSMVLEGGIRSLWRG 244
Query: 96 NGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMVR 155
NG +++I P AI+FMA+E K I + R +AGS+AG TA YP+++++
Sbjct: 245 NGINVLKIAPESAIKFMAYEQIKRAILGQQETLHVQERFVAGSLAGATAQTIIYPMEVLK 304
Query: 156 VRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKS 215
RL + G+ Y G++ + I +EG FYRG +P +LG+ PYAG+ + TLK+
Sbjct: 305 TRLTLRRTGQ--YKGLLDCARRILEREGP-RAFYRGYLPNVLGIIPYAGIDLAVYETLKN 361
Query: 216 VGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLP 275
L S +P +LVL L CG ++ Q SYP + R RMQ +
Sbjct: 362 WWLQQY-----SHDSADPGILVL-----LACGTISSTCGQIASYPLALVRTRMQAQASI- 410
Query: 276 EFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQ 327
E L+M ++++ G+R GLYRG++ N+++ IP+ ++++ YE MKQ
Sbjct: 411 EGGPQLSMLGLLRHILSQEGMR-GLYRGIAPNFMKVIPAVSISYVVYENMKQ 461
Score = 58.2 bits (139), Expect = 1e-08
Identities = 52/199 (26%), Positives = 88/199 (44%), Gaps = 25/199 (12%)
Query: 133 RLMAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGL 192
+L+AG++AG + T PLD ++V + + + I+ +++ EGG +RG
Sbjct: 188 QLVAGAVAGAVSRTGTAPLDRLKVFMQVHAS-KTNRLNILGGLRSMVL-EGGIRSLWRGN 245
Query: 193 MPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVN--LLCGGVA 250
+L +AP + + F + +K L TL HV + G +A
Sbjct: 246 GINVLKIAPESAIKFMAYEQIKRAILGQQETL----------------HVQERFVAGSLA 289
Query: 251 GAIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIR 310
GA AQTI YP +V + R+ L +++ L D + + G R YRG N +
Sbjct: 290 GATAQTIIYPMEVLKTRLTLRRT-GQYKGLL---DCARRILEREGPR-AFYRGYLPNVLG 344
Query: 311 CIPSQAVAFTTYELMKQFF 329
IP + YE +K ++
Sbjct: 345 IIPYAGIDLAVYETLKNWW 363
>gi|239755176 PREDICTED: similar to solute carrier family 25, member
25 isoform 2 [Homo sapiens]
Length = 469
Score = 171 bits (434), Expect = 6e-43
Identities = 102/296 (34%), Positives = 164/296 (55%), Gaps = 15/296 (5%)
Query: 31 RRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFL 90
R+ W R +AGG AG ++T APLDR+KVL+Q H ++G+ + ++ G
Sbjct: 181 RQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGAR 240
Query: 91 GLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYP 150
L++GNG +++I P AI+FMA+E K L+ + RL+AGS+AG A YP
Sbjct: 241 SLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYP 300
Query: 151 LDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTF 210
+++++ R+A + G+ Y+G++ + I A+E G FY+G +P +LG+ PYAG+ +
Sbjct: 301 MEVLKTRMALRKTGQ--YSGMLDCARRILARE-GVAAFYKGYVPNMLGIIPYAGIDLAVY 357
Query: 211 GTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQL 270
TLK+ L H +S +P V VL L CG ++ Q SYP + R RMQ
Sbjct: 358 ETLKNAWLQHYAV-----NSADPGVFVL-----LACGTMSSTCGQLASYPLALVRTRMQA 407
Query: 271 GTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMK 326
+ E +TM K++ G GLYRGL+ N+++ IP+ ++++ YE +K
Sbjct: 408 QASI-EGAPEVTMSSLFKHILRTEG-AFGLYRGLAPNFMKVIPAVSISYVVYENLK 461
Score = 37.7 bits (86), Expect = 0.014
Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 14/90 (15%)
Query: 243 NLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYG-----HHGIR 297
+L+ GG AGA+++T + P D + MQ+ + + M V G G
Sbjct: 189 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHA---------SRSNNMGIVGGFTQMIREGGA 239
Query: 298 KGLYRGLSLNYIRCIPSQAVAFTTYELMKQ 327
+ L+RG +N ++ P A+ F YE +K+
Sbjct: 240 RSLWRGNGINVLKIAPESAIKFMAYEQIKR 269
>gi|239755174 PREDICTED: similar to solute carrier family 25, member
25 isoform 1 [Homo sapiens]
Length = 503
Score = 171 bits (434), Expect = 6e-43
Identities = 102/296 (34%), Positives = 164/296 (55%), Gaps = 15/296 (5%)
Query: 31 RRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFL 90
R+ W R +AGG AG ++T APLDR+KVL+Q H ++G+ + ++ G
Sbjct: 215 RQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGAR 274
Query: 91 GLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYP 150
L++GNG +++I P AI+FMA+E K L+ + RL+AGS+AG A YP
Sbjct: 275 SLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYP 334
Query: 151 LDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTF 210
+++++ R+A + G+ Y+G++ + I A+E G FY+G +P +LG+ PYAG+ +
Sbjct: 335 MEVLKTRMALRKTGQ--YSGMLDCARRILARE-GVAAFYKGYVPNMLGIIPYAGIDLAVY 391
Query: 211 GTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQL 270
TLK+ L H +S +P V VL L CG ++ Q SYP + R RMQ
Sbjct: 392 ETLKNAWLQHYAV-----NSADPGVFVL-----LACGTMSSTCGQLASYPLALVRTRMQA 441
Query: 271 GTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMK 326
+ E +TM K++ G GLYRGL+ N+++ IP+ ++++ YE +K
Sbjct: 442 QASI-EGAPEVTMSSLFKHILRTEG-AFGLYRGLAPNFMKVIPAVSISYVVYENLK 495
Score = 37.7 bits (86), Expect = 0.014
Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 14/90 (15%)
Query: 243 NLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYG-----HHGIR 297
+L+ GG AGA+++T + P D + MQ+ + + M V G G
Sbjct: 223 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHA---------SRSNNMGIVGGFTQMIREGGA 273
Query: 298 KGLYRGLSLNYIRCIPSQAVAFTTYELMKQ 327
+ L+RG +N ++ P A+ F YE +K+
Sbjct: 274 RSLWRGNGINVLKIAPESAIKFMAYEQIKR 303
>gi|56699407 solute carrier family 25, member 25 isoform c [Homo
sapiens]
Length = 489
Score = 171 bits (434), Expect = 6e-43
Identities = 102/296 (34%), Positives = 164/296 (55%), Gaps = 15/296 (5%)
Query: 31 RRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFL 90
R+ W R +AGG AG ++T APLDR+KVL+Q H ++G+ + ++ G
Sbjct: 201 RQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGAR 260
Query: 91 GLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYP 150
L++GNG +++I P AI+FMA+E K L+ + RL+AGS+AG A YP
Sbjct: 261 SLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYP 320
Query: 151 LDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTF 210
+++++ R+A + G+ Y+G++ + I A+E G FY+G +P +LG+ PYAG+ +
Sbjct: 321 MEVLKTRMALRKTGQ--YSGMLDCARRILARE-GVAAFYKGYVPNMLGIIPYAGIDLAVY 377
Query: 211 GTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQL 270
TLK+ L H +S +P V VL L CG ++ Q SYP + R RMQ
Sbjct: 378 ETLKNAWLQHYAV-----NSADPGVFVL-----LACGTMSSTCGQLASYPLALVRTRMQA 427
Query: 271 GTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMK 326
+ E +TM K++ G GLYRGL+ N+++ IP+ ++++ YE +K
Sbjct: 428 QASI-EGAPEVTMSSLFKHILRTEG-AFGLYRGLAPNFMKVIPAVSISYVVYENLK 481
Score = 37.7 bits (86), Expect = 0.014
Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 14/90 (15%)
Query: 243 NLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYG-----HHGIR 297
+L+ GG AGA+++T + P D + MQ+ + + M V G G
Sbjct: 209 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHA---------SRSNNMGIVGGFTQMIREGGA 259
Query: 298 KGLYRGLSLNYIRCIPSQAVAFTTYELMKQ 327
+ L+RG +N ++ P A+ F YE +K+
Sbjct: 260 RSLWRGNGINVLKIAPESAIKFMAYEQIKR 289
>gi|56699401 solute carrier family 25, member 25 isoform a [Homo
sapiens]
Length = 469
Score = 171 bits (434), Expect = 6e-43
Identities = 102/296 (34%), Positives = 164/296 (55%), Gaps = 15/296 (5%)
Query: 31 RRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFL 90
R+ W R +AGG AG ++T APLDR+KVL+Q H ++G+ + ++ G
Sbjct: 181 RQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGAR 240
Query: 91 GLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYP 150
L++GNG +++I P AI+FMA+E K L+ + RL+AGS+AG A YP
Sbjct: 241 SLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYP 300
Query: 151 LDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTF 210
+++++ R+A + G+ Y+G++ + I A+E G FY+G +P +LG+ PYAG+ +
Sbjct: 301 MEVLKTRMALRKTGQ--YSGMLDCARRILARE-GVAAFYKGYVPNMLGIIPYAGIDLAVY 357
Query: 211 GTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQL 270
TLK+ L H +S +P V VL L CG ++ Q SYP + R RMQ
Sbjct: 358 ETLKNAWLQHYAV-----NSADPGVFVL-----LACGTMSSTCGQLASYPLALVRTRMQA 407
Query: 271 GTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMK 326
+ E +TM K++ G GLYRGL+ N+++ IP+ ++++ YE +K
Sbjct: 408 QASI-EGAPEVTMSSLFKHILRTEG-AFGLYRGLAPNFMKVIPAVSISYVVYENLK 461
Score = 37.7 bits (86), Expect = 0.014
Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 14/90 (15%)
Query: 243 NLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYG-----HHGIR 297
+L+ GG AGA+++T + P D + MQ+ + + M V G G
Sbjct: 189 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHA---------SRSNNMGIVGGFTQMIREGGA 239
Query: 298 KGLYRGLSLNYIRCIPSQAVAFTTYELMKQ 327
+ L+RG +N ++ P A+ F YE +K+
Sbjct: 240 RSLWRGNGINVLKIAPESAIKFMAYEQIKR 269
>gi|56699405 solute carrier family 25, member 25 isoform d [Homo
sapiens]
Length = 366
Score = 171 bits (434), Expect = 6e-43
Identities = 102/296 (34%), Positives = 164/296 (55%), Gaps = 15/296 (5%)
Query: 31 RRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFL 90
R+ W R +AGG AG ++T APLDR+KVL+Q H ++G+ + ++ G
Sbjct: 78 RQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGAR 137
Query: 91 GLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYP 150
L++GNG +++I P AI+FMA+E K L+ + RL+AGS+AG A YP
Sbjct: 138 SLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYP 197
Query: 151 LDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTF 210
+++++ R+A + G+ Y+G++ + I A+E G FY+G +P +LG+ PYAG+ +
Sbjct: 198 MEVLKTRMALRKTGQ--YSGMLDCARRILARE-GVAAFYKGYVPNMLGIIPYAGIDLAVY 254
Query: 211 GTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQL 270
TLK+ L H +S +P V VL L CG ++ Q SYP + R RMQ
Sbjct: 255 ETLKNAWLQHYAV-----NSADPGVFVL-----LACGTMSSTCGQLASYPLALVRTRMQA 304
Query: 271 GTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMK 326
+ E +TM K++ G GLYRGL+ N+++ IP+ ++++ YE +K
Sbjct: 305 QASI-EGAPEVTMSSLFKHILRTEG-AFGLYRGLAPNFMKVIPAVSISYVVYENLK 358
Score = 37.7 bits (86), Expect = 0.014
Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 14/90 (15%)
Query: 243 NLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYG-----HHGIR 297
+L+ GG AGA+++T + P D + MQ+ + + M V G G
Sbjct: 86 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHA---------SRSNNMGIVGGFTQMIREGGA 136
Query: 298 KGLYRGLSLNYIRCIPSQAVAFTTYELMKQ 327
+ L+RG +N ++ P A+ F YE +K+
Sbjct: 137 RSLWRGNGINVLKIAPESAIKFMAYEQIKR 166
>gi|56699403 solute carrier family 25, member 25 isoform b [Homo
sapiens]
Length = 503
Score = 171 bits (434), Expect = 6e-43
Identities = 102/296 (34%), Positives = 164/296 (55%), Gaps = 15/296 (5%)
Query: 31 RRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFL 90
R+ W R +AGG AG ++T APLDR+KVL+Q H ++G+ + ++ G
Sbjct: 215 RQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGAR 274
Query: 91 GLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYP 150
L++GNG +++I P AI+FMA+E K L+ + RL+AGS+AG A YP
Sbjct: 275 SLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYP 334
Query: 151 LDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTF 210
+++++ R+A + G+ Y+G++ + I A+E G FY+G +P +LG+ PYAG+ +
Sbjct: 335 MEVLKTRMALRKTGQ--YSGMLDCARRILARE-GVAAFYKGYVPNMLGIIPYAGIDLAVY 391
Query: 211 GTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQL 270
TLK+ L H +S +P V VL L CG ++ Q SYP + R RMQ
Sbjct: 392 ETLKNAWLQHYAV-----NSADPGVFVL-----LACGTMSSTCGQLASYPLALVRTRMQA 441
Query: 271 GTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMK 326
+ E +TM K++ G GLYRGL+ N+++ IP+ ++++ YE +K
Sbjct: 442 QASI-EGAPEVTMSSLFKHILRTEG-AFGLYRGLAPNFMKVIPAVSISYVVYENLK 495
Score = 37.7 bits (86), Expect = 0.014
Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 14/90 (15%)
Query: 243 NLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYG-----HHGIR 297
+L+ GG AGA+++T + P D + MQ+ + + M V G G
Sbjct: 223 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHA---------SRSNNMGIVGGFTQMIREGGA 273
Query: 298 KGLYRGLSLNYIRCIPSQAVAFTTYELMKQ 327
+ L+RG +N ++ P A+ F YE +K+
Sbjct: 274 RSLWRGNGINVLKIAPESAIKFMAYEQIKR 303
>gi|21687151 mitochondrial solute carrier protein [Homo sapiens]
Length = 341
Score = 140 bits (352), Expect = 2e-33
Identities = 90/295 (30%), Positives = 144/295 (48%), Gaps = 27/295 (9%)
Query: 41 LAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAMM 100
L G+AG + + APL+ VL Q G ++ V + EG L+KGN
Sbjct: 17 LCAGLAGTLSLSLTAPLELATVLAQVGVVRGHARGPWATGHRVWRAEGLRALWKGNAVAC 76
Query: 101 IRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMVRVRLAF 160
+R+FP A+Q A+ + L T LG +MAGS+AGM + I TYP D+++ RL
Sbjct: 77 LRLFPCSAVQLAAYRKFVVLFTDDLGHISQWSSIMAGSLAGMVSTIVTYPTDLIKTRLIM 136
Query: 161 QVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVGLSH 220
Q E SY G++HAF TIY +E GF YRG+ T++G P++ S + L+ +
Sbjct: 137 QNILEPSYRGLLHAFSTIYQQE-GFLALYRGVSLTVVGALPFSAGSLLVYMNLEKIW--- 192
Query: 221 APTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQL--------GT 272
+ + + N+ +A A+ QT+S+PF+ +R+MQ G
Sbjct: 193 --------NGPRDQFSLPQNFANVC---LAAAVTQTLSFPFETVKRKMQAQSPYLPHSGG 241
Query: 273 VLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQ 327
V F + D + + G+ GL+ GL+ N ++ +P + F+T+E K+
Sbjct: 242 VDVHFSGAV---DCFRQIVKAQGV-LGLWNGLTANLLKIVPYFGIMFSTFEFCKR 292
Score = 58.9 bits (141), Expect = 6e-09
Identities = 45/188 (23%), Positives = 78/188 (41%), Gaps = 9/188 (4%)
Query: 39 SFLAGGIAGCCAKTTVAPLDRVKVLLQAHN-HHYKHLGVFSALRAVPQKEGFLGLYKGNG 97
S +AG +AG + P D +K L N + G+ A + Q+EGFL LY+G
Sbjct: 109 SIMAGSLAGMVSTIVTYPTDLIKTRLIMQNILEPSYRGLLHAFSTIYQQEGFLALYRGVS 168
Query: 98 AMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMVRVR 157
++ P+ A + + + + + +A ++P + V+ +
Sbjct: 169 LTVVGALPFSAGSLLVYMNLEKIWNGPRDQFSLPQNFANVCLAAAVTQTLSFPFETVKRK 228
Query: 158 LAFQVKG-EHS------YTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTF 210
+ Q HS ++G + F+ I K G G + GL +L + PY G+ F TF
Sbjct: 229 MQAQSPYLPHSGGVDVHFSGAVDCFRQI-VKAQGVLGLWNGLTANLLKIVPYFGIMFSTF 287
Query: 211 GTLKSVGL 218
K + L
Sbjct: 288 EFCKRICL 295
Score = 41.2 bits (95), Expect = 0.001
Identities = 27/98 (27%), Positives = 43/98 (43%), Gaps = 8/98 (8%)
Query: 31 RRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLG--------VFSALRA 82
R F ++F +A +T P + VK +QA + + H G R
Sbjct: 196 RDQFSLPQNFANVCLAAAVTQTLSFPFETVKRKMQAQSPYLPHSGGVDVHFSGAVDCFRQ 255
Query: 83 VPQKEGFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTL 120
+ + +G LGL+ G A +++I PY I F FE K +
Sbjct: 256 IVKAQGVLGLWNGLTANLLKIVPYFGIMFSTFEFCKRI 293
Score = 39.7 bits (91), Expect = 0.004
Identities = 42/202 (20%), Positives = 83/202 (41%), Gaps = 27/202 (13%)
Query: 133 RLMAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGL 192
RL+ +AG ++ T PL++ V V H+ + A+ G ++G
Sbjct: 15 RLLCAGLAGTLSLSLTAPLELATVLAQVGVVRGHARGPWATGHRVWRAE--GLRALWKGN 72
Query: 193 MPTILGMAPYAGV---SFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGV 249
L + P + V ++ F L + L H + +++ G +
Sbjct: 73 AVACLRLFPCSAVQLAAYRKFVVLFTDDLGH-----------------ISQWSSIMAGSL 115
Query: 250 AGAIAQTISYPFDVTRRRMQLGTVL-PEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNY 308
AG ++ ++YP D+ + R+ + +L P + L T +Y G LYRG+SL
Sbjct: 116 AGMVSTIVTYPTDLIKTRLIMQNILEPSYRGLLHAFST---IYQQEGFL-ALYRGVSLTV 171
Query: 309 IRCIPSQAVAFTTYELMKQFFH 330
+ +P A + Y +++ ++
Sbjct: 172 VGALPFSAGSLLVYMNLEKIWN 193
>gi|186928856 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 126 bits (317), Expect = 2e-29
Identities = 91/311 (29%), Positives = 148/311 (47%), Gaps = 40/311 (12%)
Query: 41 LAGGIAGCCAKTTVAPLDRVKVLLQAHNHHY-------KHLGVFSALRAVPQKEGFLGLY 93
+AG ++G + ++P D +K+ Q + K+ G+ A R + Q+EG +
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 94 KGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVH-------RLMAGSMAGMTAVI 146
KG+ I YGA+QF++FE + T+L G V+ + G +A A +
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFE-----MLTELVHRGSVYDAREFSVHFVCGGLAACMATL 134
Query: 147 CTYPLDMVRVRLAFQVKGEHS-YTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGV 205
+P+D++R R A Q GE Y + HA T+Y EG FY+GL PT++ + PYAG+
Sbjct: 135 TVHPVDVLRTRFAAQ--GEPKVYNTLRHAVGTMYRSEGPQV-FYKGLAPTLIAIFPYAGL 191
Query: 206 SFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTR 265
F + +LK + P N N+ NLLCG AG I++T++YP D+ +
Sbjct: 192 QFSCYSSLKHLYKWAIPA----EGKKNENLQ------NLLCGSGAGVISKTLTYPLDLFK 241
Query: 266 RRMQLG------TVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAF 319
+R+Q+G + + + D K V G G ++GLS + ++ S F
Sbjct: 242 KRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEG-ALGFFKGLSPSLLKAALSTGFMF 300
Query: 320 TTYELMKQFFH 330
+YE FH
Sbjct: 301 FSYEFFCNVFH 311
Score = 87.8 bits (216), Expect = 1e-17
Identities = 60/185 (32%), Positives = 91/185 (49%), Gaps = 17/185 (9%)
Query: 40 FLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAM 99
F+ GG+A C A TV P+D ++ A + + A+ + + EG YKG
Sbjct: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPT 181
Query: 100 MIRIFPYGAIQFMAFEHYKTLITTKLGISG----HVHRLMAGSMAGMTAVICTYPLDMVR 155
+I IFPY +QF + K L + G ++ L+ GS AG+ + TYPLD+ +
Sbjct: 182 LIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFK 241
Query: 156 VRLAFQVKG-EHS---------YTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGV 205
RL QV G EH+ Y G++ K + KEG GF++GL P++L A G
Sbjct: 242 KRL--QVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGA-LGFFKGLSPSLLKAALSTGF 298
Query: 206 SFFTF 210
FF++
Sbjct: 299 MFFSY 303
Score = 40.0 bits (92), Expect = 0.003
Identities = 25/90 (27%), Positives = 40/90 (44%), Gaps = 9/90 (10%)
Query: 37 LRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHY---------KHLGVFSALRAVPQKE 87
L++ L G AG +KT PLD K LQ + ++ G+ + V QKE
Sbjct: 217 LQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKE 276
Query: 88 GFLGLYKGNGAMMIRIFPYGAIQFMAFEHY 117
G LG +KG +++ F ++E +
Sbjct: 277 GALGFFKGLSPSLLKAALSTGFMFFSYEFF 306
>gi|186928860 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 126 bits (317), Expect = 2e-29
Identities = 91/311 (29%), Positives = 148/311 (47%), Gaps = 40/311 (12%)
Query: 41 LAGGIAGCCAKTTVAPLDRVKVLLQAHNHHY-------KHLGVFSALRAVPQKEGFLGLY 93
+AG ++G + ++P D +K+ Q + K+ G+ A R + Q+EG +
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 94 KGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVH-------RLMAGSMAGMTAVI 146
KG+ I YGA+QF++FE + T+L G V+ + G +A A +
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFE-----MLTELVHRGSVYDAREFSVHFVCGGLAACMATL 134
Query: 147 CTYPLDMVRVRLAFQVKGEHS-YTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGV 205
+P+D++R R A Q GE Y + HA T+Y EG FY+GL PT++ + PYAG+
Sbjct: 135 TVHPVDVLRTRFAAQ--GEPKVYNTLRHAVGTMYRSEGPQV-FYKGLAPTLIAIFPYAGL 191
Query: 206 SFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTR 265
F + +LK + P N N+ NLLCG AG I++T++YP D+ +
Sbjct: 192 QFSCYSSLKHLYKWAIPA----EGKKNENLQ------NLLCGSGAGVISKTLTYPLDLFK 241
Query: 266 RRMQLG------TVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAF 319
+R+Q+G + + + D K V G G ++GLS + ++ S F
Sbjct: 242 KRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEG-ALGFFKGLSPSLLKAALSTGFMF 300
Query: 320 TTYELMKQFFH 330
+YE FH
Sbjct: 301 FSYEFFCNVFH 311
Score = 87.8 bits (216), Expect = 1e-17
Identities = 60/185 (32%), Positives = 91/185 (49%), Gaps = 17/185 (9%)
Query: 40 FLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAM 99
F+ GG+A C A TV P+D ++ A + + A+ + + EG YKG
Sbjct: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPT 181
Query: 100 MIRIFPYGAIQFMAFEHYKTLITTKLGISG----HVHRLMAGSMAGMTAVICTYPLDMVR 155
+I IFPY +QF + K L + G ++ L+ GS AG+ + TYPLD+ +
Sbjct: 182 LIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFK 241
Query: 156 VRLAFQVKG-EHS---------YTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGV 205
RL QV G EH+ Y G++ K + KEG GF++GL P++L A G
Sbjct: 242 KRL--QVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGA-LGFFKGLSPSLLKAALSTGF 298
Query: 206 SFFTF 210
FF++
Sbjct: 299 MFFSY 303
Score = 40.0 bits (92), Expect = 0.003
Identities = 25/90 (27%), Positives = 40/90 (44%), Gaps = 9/90 (10%)
Query: 37 LRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHY---------KHLGVFSALRAVPQKE 87
L++ L G AG +KT PLD K LQ + ++ G+ + V QKE
Sbjct: 217 LQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKE 276
Query: 88 GFLGLYKGNGAMMIRIFPYGAIQFMAFEHY 117
G LG +KG +++ F ++E +
Sbjct: 277 GALGFFKGLSPSLLKAALSTGFMFFSYEFF 306
>gi|186928858 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 126 bits (317), Expect = 2e-29
Identities = 91/311 (29%), Positives = 148/311 (47%), Gaps = 40/311 (12%)
Query: 41 LAGGIAGCCAKTTVAPLDRVKVLLQAHNHHY-------KHLGVFSALRAVPQKEGFLGLY 93
+AG ++G + ++P D +K+ Q + K+ G+ A R + Q+EG +
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 94 KGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVH-------RLMAGSMAGMTAVI 146
KG+ I YGA+QF++FE + T+L G V+ + G +A A +
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFE-----MLTELVHRGSVYDAREFSVHFVCGGLAACMATL 134
Query: 147 CTYPLDMVRVRLAFQVKGEHS-YTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGV 205
+P+D++R R A Q GE Y + HA T+Y EG FY+GL PT++ + PYAG+
Sbjct: 135 TVHPVDVLRTRFAAQ--GEPKVYNTLRHAVGTMYRSEGPQV-FYKGLAPTLIAIFPYAGL 191
Query: 206 SFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTR 265
F + +LK + P N N+ NLLCG AG I++T++YP D+ +
Sbjct: 192 QFSCYSSLKHLYKWAIPA----EGKKNENLQ------NLLCGSGAGVISKTLTYPLDLFK 241
Query: 266 RRMQLG------TVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAF 319
+R+Q+G + + + D K V G G ++GLS + ++ S F
Sbjct: 242 KRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEG-ALGFFKGLSPSLLKAALSTGFMF 300
Query: 320 TTYELMKQFFH 330
+YE FH
Sbjct: 301 FSYEFFCNVFH 311
Score = 87.8 bits (216), Expect = 1e-17
Identities = 60/185 (32%), Positives = 91/185 (49%), Gaps = 17/185 (9%)
Query: 40 FLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAM 99
F+ GG+A C A TV P+D ++ A + + A+ + + EG YKG
Sbjct: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPT 181
Query: 100 MIRIFPYGAIQFMAFEHYKTLITTKLGISG----HVHRLMAGSMAGMTAVICTYPLDMVR 155
+I IFPY +QF + K L + G ++ L+ GS AG+ + TYPLD+ +
Sbjct: 182 LIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFK 241
Query: 156 VRLAFQVKG-EHS---------YTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGV 205
RL QV G EH+ Y G++ K + KEG GF++GL P++L A G
Sbjct: 242 KRL--QVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGA-LGFFKGLSPSLLKAALSTGF 298
Query: 206 SFFTF 210
FF++
Sbjct: 299 MFFSY 303
Score = 40.0 bits (92), Expect = 0.003
Identities = 25/90 (27%), Positives = 40/90 (44%), Gaps = 9/90 (10%)
Query: 37 LRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHY---------KHLGVFSALRAVPQKE 87
L++ L G AG +KT PLD K LQ + ++ G+ + V QKE
Sbjct: 217 LQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKE 276
Query: 88 GFLGLYKGNGAMMIRIFPYGAIQFMAFEHY 117
G LG +KG +++ F ++E +
Sbjct: 277 GALGFFKGLSPSLLKAALSTGFMFFSYEFF 306
>gi|13775208 solute carrier family 25 (mitochondrial carrier;
adenine nucleotide translocator), member 31 [Homo
sapiens]
Length = 315
Score = 125 bits (313), Expect = 7e-29
Identities = 96/311 (30%), Positives = 144/311 (46%), Gaps = 37/311 (11%)
Query: 38 RSFLAGGIAGCCAKTTVAPLDRVKVLLQAH------NHHYKHLGVFSALRAVPQKEGFLG 91
+ LAGG+A +KT VAP++RVK+LLQ + ++ G+ L +P+++GF
Sbjct: 22 KDLLAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPREQGFFS 81
Query: 92 LYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHR-----LMAGSMAGMTAVI 146
++GN A +IR FP A+ F + YK L + + R L +G AG T++
Sbjct: 82 FWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGATSLC 141
Query: 147 CTYPLDMVRVRLAFQV-KG--EHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYA 203
YPLD R RL + KG E + G+ I AK G G Y+G ++ G+ Y
Sbjct: 142 VVYPLDFARTRLGVDIGKGPEERQFKGLGDCIMKI-AKSDGIAGLYQGFGVSVQGIIVYR 200
Query: 204 GVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDV 263
F + T+K LL +P V V C G+ +SYPFD
Sbjct: 201 ASYFGAYDTVKG--------LLPKPKKTPFLVSFFIAQVVTTCSGI-------LSYPFDT 245
Query: 264 TRRR--MQLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTT 321
RRR MQ G +++ L D +Y H GI +RG N +R A+
Sbjct: 246 VRRRMMMQSGEAKRQYKGTL---DCFVKIYQHEGI-SSFFRGAFSNVLRG-TGGALVLVL 300
Query: 322 YELMKQFFHLN 332
Y+ +K+FFH++
Sbjct: 301 YDKIKEFFHID 311
Score = 57.0 bits (136), Expect = 2e-08
Identities = 46/170 (27%), Positives = 74/170 (43%), Gaps = 11/170 (6%)
Query: 35 YWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQA------HNHHYKHLGVFSALRAVPQKEG 88
++L + +GG AG + V PLD + L +K LG + + + +G
Sbjct: 124 WFLANLASGGAAGATSLCVVYPLDFARTRLGVDIGKGPEERQFKGLG--DCIMKIAKSDG 181
Query: 89 FLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICT 148
GLY+G G + I Y A F A++ K L+ V +A + + ++ +
Sbjct: 182 IAGLYQGFGVSVQGIIVYRASYFGAYDTVKGLLPKPKKTPFLVSFFIAQVVTTCSGIL-S 240
Query: 149 YPLDMVRVRLAFQV-KGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTIL 197
YP D VR R+ Q + + Y G + F IY E G F+RG +L
Sbjct: 241 YPFDTVRRRMMMQSGEAKRQYKGTLDCFVKIYQHE-GISSFFRGAFSNVL 289
>gi|149274607 solute carrier family 25, member 41 [Homo sapiens]
Length = 370
Score = 124 bits (311), Expect = 1e-28
Identities = 87/289 (30%), Positives = 142/289 (49%), Gaps = 21/289 (7%)
Query: 41 LAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAMM 100
L+G +AG ++T APLDR KV +Q ++ + L+++ Q+ GF L++GNG +
Sbjct: 97 LSGAMAGAVSRTGTAPLDRAKVYMQVYSSKTNFTNLLGGLQSMVQEGGFRSLWRGNGINV 156
Query: 101 IRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMVRVRLAF 160
++I P AI+F FE K G RL+AGS+A + P+++++ RL
Sbjct: 157 LKIAPEYAIKFSVFEQCKNYFCGIQGSPPFQERLLAGSLAVAISQTLINPMEVLKTRLTL 216
Query: 161 QVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVGLSH 220
+ G+ Y G++ + I +E G YRG +P +LG+ PYA + L+ +
Sbjct: 217 RRTGQ--YKGLLDCARQILQRE-GTRALYRGYLPNMLGIIPYACTDLAVYEMLQCFWVKS 273
Query: 221 APTLLGRPSSDNPNVLVLKTHVNL--LCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFE 278
GR D P+ LV + V L CG Q SYP + R RMQ +
Sbjct: 274 -----GRDMGD-PSGLVSLSSVTLSTTCG-------QMASYPLTLVRTRMQAQDTVEGSN 320
Query: 279 KCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQ 327
TMR ++ + G GLYRG++ ++ +P+ +++ YE MK+
Sbjct: 321 P--TMRGVLQRILAQQG-WLGLYRGMTPTLLKVLPAGGISYVVYEAMKK 366
Score = 58.9 bits (141), Expect = 6e-09
Identities = 52/198 (26%), Positives = 90/198 (45%), Gaps = 25/198 (12%)
Query: 134 LMAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLM 193
L++G+MAG + T PLD +V + + ++T ++ +++ +EGGF +RG
Sbjct: 96 LLSGAMAGAVSRTGTAPLDRAKVYMQVY-SSKTNFTNLLGGLQSM-VQEGGFRSLWRGNG 153
Query: 194 PTILGMAPYAGVSFFTFGTLKSV--GLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAG 251
+L +AP + F F K+ G+ +P R LL G +A
Sbjct: 154 INVLKIAPEYAIKFSVFEQCKNYFCGIQGSPPFQER----------------LLAGSLAV 197
Query: 252 AIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRC 311
AI+QT+ P +V + R+ L +++ L D + + G R LYRG N +
Sbjct: 198 AISQTLINPMEVLKTRLTLRRT-GQYKGLL---DCARQILQREGTR-ALYRGYLPNMLGI 252
Query: 312 IPSQAVAFTTYELMKQFF 329
IP YE+++ F+
Sbjct: 253 IPYACTDLAVYEMLQCFW 270
Score = 42.7 bits (99), Expect = 4e-04
Identities = 33/130 (25%), Positives = 57/130 (43%), Gaps = 12/130 (9%)
Query: 208 FTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVN--------LLCGGVAGAIAQTISY 259
+ FG + L H P+ + + V V V+ LL G +AGA+++T +
Sbjct: 52 YAFGHMHDNNLEHLPSQQVLDTGEQLMVPVEVLEVDNKEALWKFLLSGAMAGAVSRTGTA 111
Query: 260 PFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAF 319
P D + MQ+ + F L +M G + L+RG +N ++ P A+ F
Sbjct: 112 PLDRAKVYMQVYSSKTNFTNLLGGLQSMV----QEGGFRSLWRGNGINVLKIAPEYAIKF 167
Query: 320 TTYELMKQFF 329
+ +E K +F
Sbjct: 168 SVFEQCKNYF 177
>gi|55749577 solute carrier family 25 (mitochondrial carrier;
adenine nucleotide translocator), member 4 [Homo
sapiens]
Length = 298
Score = 111 bits (278), Expect = 8e-25
Identities = 79/251 (31%), Positives = 121/251 (48%), Gaps = 34/251 (13%)
Query: 36 WLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAH------NHHYKHLGVFSALRAVPQKEGF 89
+L+ FLAGG+A +KT VAP++RVK+LLQ + ++ G+ + +P+++GF
Sbjct: 8 FLKDFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGF 67
Query: 90 LGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGH-------VHRLMAGSMAGM 142
L ++GN A +IR FP A+ F + YK L G+ H L +G AG
Sbjct: 68 LSFWRGNLANVIRYFPTQALNFAFKDKYKQLFLG--GVDRHKQFWRYFAGNLASGGAAGA 125
Query: 143 TAVICTYPLDMVRVRLAFQV-KG--EHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGM 199
T++ YPLD R RLA V KG + + G+ I+ K G G Y+G ++ G+
Sbjct: 126 TSLCFVYPLDFARTRLAADVGKGAAQREFHGLGDCIIKIF-KSDGLRGLYQGFNVSVQGI 184
Query: 200 APYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISY 259
Y F + T K + P N ++ V+ + A+A +SY
Sbjct: 185 IIYRAAYFGVYDTAKGM----------LPDPKNVHIF-----VSWMIAQSVTAVAGLVSY 229
Query: 260 PFDVTRRRMQL 270
PFD RRRM +
Sbjct: 230 PFDTVRRRMMM 240
Score = 52.4 bits (124), Expect = 6e-07
Identities = 52/201 (25%), Positives = 80/201 (39%), Gaps = 23/201 (11%)
Query: 135 MAGSMAGMTAVICTYPLDMVRVRLAFQ-----VKGEHSYTGIIHAFKTIYAKEGGFFGFY 189
+AG +A + P++ V++ L Q + E Y GII I KE GF F+
Sbjct: 13 LAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRI-PKEQGFLSFW 71
Query: 190 RGLMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGV 249
RG + ++ P ++F K + L D NL GG
Sbjct: 72 RGNLANVIRYFPTQALNFAFKDKYKQLFLGGV---------DRHKQFWRYFAGNLASGGA 122
Query: 250 AGAIAQTISYPFDVTRRRMQL----GTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLS 305
AGA + YP D R R+ G EF + D + ++ G+R GLY+G +
Sbjct: 123 AGATSLCFVYPLDFARTRLAADVGKGAAQREFHG---LGDCIIKIFKSDGLR-GLYQGFN 178
Query: 306 LNYIRCIPSQAVAFTTYELMK 326
++ I +A F Y+ K
Sbjct: 179 VSVQGIIIYRAAYFGVYDTAK 199
Score = 52.4 bits (124), Expect = 6e-07
Identities = 47/181 (25%), Positives = 82/181 (45%), Gaps = 11/181 (6%)
Query: 26 GGPTTRRDF--YWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAH----NHHYKHLGVFSA 79
GG + F Y+ + +GG AG + V PLD + L A + G+
Sbjct: 101 GGVDRHKQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKGAAQREFHGLGDC 160
Query: 80 LRAVPQKEGFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSM 139
+ + + +G GLY+G + I Y A F ++ K ++ + V ++A S+
Sbjct: 161 IIKIFKSDGLRGLYQGFNVSVQGIIIYRAAYFGVYDTAKGMLPDPKNVHIFVSWMIAQSV 220
Query: 140 AGMTAVICTYPLDMVRVRLAFQV--KG-EHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTI 196
+ ++ +YP D VR R+ Q KG + YTG + ++ I AK+ G F++G +
Sbjct: 221 TAVAGLV-SYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKI-AKDEGAKAFFKGAWSNV 278
Query: 197 L 197
L
Sbjct: 279 L 279
Score = 29.6 bits (65), Expect = 3.9
Identities = 23/90 (25%), Positives = 41/90 (45%), Gaps = 4/90 (4%)
Query: 243 NLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEF---EKCLTMRDTMKYVYGHHGIRKG 299
+ L GGVA A+++T P + + +Q+ + ++ + D + + G
Sbjct: 11 DFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLS- 69
Query: 300 LYRGLSLNYIRCIPSQAVAFTTYELMKQFF 329
+RG N IR P+QA+ F + KQ F
Sbjct: 70 FWRGNLANVIRYFPTQALNFAFKDKYKQLF 99
>gi|156071462 solute carrier family 25, member A6 [Homo sapiens]
Length = 298
Score = 110 bits (274), Expect = 2e-24
Identities = 80/259 (30%), Positives = 120/259 (46%), Gaps = 38/259 (14%)
Query: 30 TRRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQ--------AHNHHYKHLGVFSALR 81
T + + + FLAGGIA +KT VAP++RVK+LLQ A + YK G+ +
Sbjct: 2 TEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYK--GIVDCIV 59
Query: 82 AVPQKEGFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVH-------RL 134
+P+++G L ++GN A +IR FP A+ F + YK + G+ H L
Sbjct: 60 RIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLG--GVDKHTQFWRYFAGNL 117
Query: 135 MAGSMAGMTAVICTYPLDMVRVRLAFQV---KGEHSYTGIIHAFKTIYAKEGGFFGFYRG 191
+G AG T++ YPLD R RLA V E + G+ I K G G Y+G
Sbjct: 118 ASGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKI-TKSDGIRGLYQG 176
Query: 192 LMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAG 251
++ G+ Y F + T K + P N +++ V+ +
Sbjct: 177 FSVSVQGIIIYRAAYFGVYDTAKGM----------LPDPKNTHIV-----VSWMIAQTVT 221
Query: 252 AIAQTISYPFDVTRRRMQL 270
A+A +SYPFD RRRM +
Sbjct: 222 AVAGVVSYPFDTVRRRMMM 240
Score = 53.9 bits (128), Expect = 2e-07
Identities = 46/172 (26%), Positives = 78/172 (45%), Gaps = 13/172 (7%)
Query: 35 YWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAH------NHHYKHLGVFSALRAVPQKEG 88
Y+ + +GG AG + V PLD + L A ++ LG L + + +G
Sbjct: 112 YFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLG--DCLVKITKSDG 169
Query: 89 FLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICT 148
GLY+G + I Y A F ++ K ++ V ++A ++ + V+ +
Sbjct: 170 IRGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVV-S 228
Query: 149 YPLDMVRVRLAFQV--KG-EHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTIL 197
YP D VR R+ Q KG + YTG + ++ I+ EGG F++G +L
Sbjct: 229 YPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIFRDEGG-KAFFKGAWSNVL 279
Score = 48.1 bits (113), Expect = 1e-05
Identities = 49/198 (24%), Positives = 77/198 (38%), Gaps = 17/198 (8%)
Query: 135 MAGSMAGMTAVICTYPLDMVRVRLAFQ-----VKGEHSYTGIIHAFKTIYAKEGGFFGFY 189
+AG +A + P++ V++ L Q + + Y GI+ I KE G F+
Sbjct: 13 LAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRI-PKEQGVLSFW 71
Query: 190 RGLMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGV 249
RG + ++ P ++F K + L D NL GG
Sbjct: 72 RGNLANVIRYFPTQALNFAFKDKYKQIFLGGV---------DKHTQFWRYFAGNLASGGA 122
Query: 250 AGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLT-MRDTMKYVYGHHGIRKGLYRGLSLNY 308
AGA + YP D R R+ E+ + D + + GIR GLY+G S++
Sbjct: 123 AGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIR-GLYQGFSVSV 181
Query: 309 IRCIPSQAVAFTTYELMK 326
I +A F Y+ K
Sbjct: 182 QGIIIYRAAYFGVYDTAK 199
Score = 30.8 bits (68), Expect = 1.8
Identities = 23/90 (25%), Positives = 42/90 (46%), Gaps = 4/90 (4%)
Query: 243 NLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEF---EKCLTMRDTMKYVYGHHGIRKG 299
+ L GG+A AI++T P + + +Q+ + ++ + D + + G+
Sbjct: 11 DFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLS- 69
Query: 300 LYRGLSLNYIRCIPSQAVAFTTYELMKQFF 329
+RG N IR P+QA+ F + KQ F
Sbjct: 70 FWRGNLANVIRYFPTQALNFAFKDKYKQIF 99
>gi|156071459 solute carrier family 25, member 5 [Homo sapiens]
Length = 298
Score = 105 bits (263), Expect = 4e-23
Identities = 76/250 (30%), Positives = 115/250 (46%), Gaps = 36/250 (14%)
Query: 38 RSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHL-------GVFSALRAVPQKEGFL 90
+ FLAGG+A +KT VAP++RVK+LLQ H K + G+ + +P+++G L
Sbjct: 10 KDFLAGGVAAAISKTAVAPIERVKLLLQV-QHASKQITADKQYKGIIDCVVRIPKEQGVL 68
Query: 91 GLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVH-------RLMAGSMAGMT 143
++GN A +IR FP A+ F + YK + G+ L +G AG T
Sbjct: 69 SFWRGNLANVIRYFPTQALNFAFKDKYKQIFLG--GVDKRTQFWLYFAGNLASGGAAGAT 126
Query: 144 AVICTYPLDMVRVRLAFQV---KGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMA 200
++ YPLD R RLA V E + G+ IY K G G Y+G ++ G+
Sbjct: 127 SLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIY-KSDGIKGLYQGFNVSVQGII 185
Query: 201 PYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYP 260
Y F + T K + P N +++ ++ + A+A SYP
Sbjct: 186 IYRAAYFGIYDTAKGM----------LPDPKNTHIV-----ISWMIAQTVTAVAGLTSYP 230
Query: 261 FDVTRRRMQL 270
FD RRRM +
Sbjct: 231 FDTVRRRMMM 240
Score = 52.4 bits (124), Expect = 6e-07
Identities = 51/198 (25%), Positives = 79/198 (39%), Gaps = 17/198 (8%)
Query: 135 MAGSMAGMTAVICTYPLDMVRVRLAFQ-----VKGEHSYTGIIHAFKTIYAKEGGFFGFY 189
+AG +A + P++ V++ L Q + + Y GII I KE G F+
Sbjct: 13 LAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRI-PKEQGVLSFW 71
Query: 190 RGLMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGV 249
RG + ++ P ++F K + L D L NL GG
Sbjct: 72 RGNLANVIRYFPTQALNFAFKDKYKQIFLGGV---------DKRTQFWLYFAGNLASGGA 122
Query: 250 AGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLT-MRDTMKYVYGHHGIRKGLYRGLSLNY 308
AGA + YP D R R+ E+ + D + +Y GI KGLY+G +++
Sbjct: 123 AGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGI-KGLYQGFNVSV 181
Query: 309 IRCIPSQAVAFTTYELMK 326
I +A F Y+ K
Sbjct: 182 QGIIIYRAAYFGIYDTAK 199
Score = 51.2 bits (121), Expect = 1e-06
Identities = 52/185 (28%), Positives = 84/185 (45%), Gaps = 19/185 (10%)
Query: 26 GGPTTRRDF--YWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAH----NHHYKHLGVFSA 79
GG R F Y+ + +GG AG + V PLD + L A + G+
Sbjct: 101 GGVDKRTQFWLYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKAGAEREFRGLGDC 160
Query: 80 LRAVPQKEGFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLI----TTKLGISGHVHRLM 135
L + + +G GLY+G + I Y A F ++ K ++ T + IS + + +
Sbjct: 161 LVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAKGMLPDPKNTHIVISWMIAQTV 220
Query: 136 AGSMAGMTAVICTYPLDMVRVRLAFQV--KG-EHSYTGIIHAFKTIYAKEGGFFGFYRGL 192
++AG+T +YP D VR R+ Q KG + YTG + ++ I EGG F++G
Sbjct: 221 T-AVAGLT----SYPFDTVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGG-KAFFKGA 274
Query: 193 MPTIL 197
+L
Sbjct: 275 WSNVL 279
Score = 31.2 bits (69), Expect = 1.3
Identities = 24/90 (26%), Positives = 42/90 (46%), Gaps = 4/90 (4%)
Query: 243 NLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEF---EKCLTMRDTMKYVYGHHGIRKG 299
+ L GGVA AI++T P + + +Q+ + ++ + D + + G+
Sbjct: 11 DFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLS- 69
Query: 300 LYRGLSLNYIRCIPSQAVAFTTYELMKQFF 329
+RG N IR P+QA+ F + KQ F
Sbjct: 70 FWRGNLANVIRYFPTQALNFAFKDKYKQIF 99
>gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens]
Length = 301
Score = 102 bits (253), Expect = 6e-22
Identities = 83/301 (27%), Positives = 130/301 (43%), Gaps = 23/301 (7%)
Query: 37 LRSFLAGGIAGCCAKTTVAPLDRVKVLLQAH-----NHHYKHLGVFSALRAVPQKEGFLG 91
L++ LAGG G C PLD VKV LQ + G F R +EG G
Sbjct: 11 LKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITG 70
Query: 92 LYKGNGAMMIRIFPYGAIQFMAFEHYKTLITT-KLGISGHVHRLMAGSMAGMTAVICTYP 150
LY+G A +I + P A+ F F K L + + AG ++G+ P
Sbjct: 71 LYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTP 130
Query: 151 LDMVRVRLAFQV-KGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFT 209
+ ++ L Q GE YTG + K +Y +E G G Y+G + T++ P +G+ F T
Sbjct: 131 GERIKCLLQIQASSGESKYTGTLDCAKKLY-QEFGIRGIYKGTVLTLMRDVPASGMYFMT 189
Query: 210 FGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQ 269
+ LK++ + + V L L+ GG+AG ++ P DV + R Q
Sbjct: 190 YEWLKNIF-----------TPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQ 238
Query: 270 LGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQFF 329
P + RD ++ + G+ LY+G + IR P+ A F +E+ +F
Sbjct: 239 ---TAPPGKYPNGFRDVLRELIRDEGV-TSLYKGFNAVMIRAFPANAACFLGFEVAMKFL 294
Query: 330 H 330
+
Sbjct: 295 N 295
>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
sapiens]
Length = 675
Score = 96.3 bits (238), Expect = 3e-20
Identities = 79/299 (26%), Positives = 132/299 (44%), Gaps = 26/299 (8%)
Query: 40 FLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGV------FSALRAVPQKEGFLGLY 93
F G +AG T V P+D VK +Q +G F + V + EGF GLY
Sbjct: 332 FGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLY 391
Query: 94 KGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDM 153
+G ++ + P AI+ + + K G ++AG AG + VI T PL++
Sbjct: 392 RGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPLEI 451
Query: 154 VRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTL 213
V++RL QV GE + + A + ++ GFFG Y+G L P++ + F + +
Sbjct: 452 VKIRL--QVAGEITTGPRVSALSVV--RDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHV 507
Query: 214 KSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTV 273
K+ + +P L LL G +AG A ++ P DV + R+Q+
Sbjct: 508 KA-------SFANEDGQVSPGSL-------LLAGAIAGMPAASLVTPADVIKTRLQVAAR 553
Query: 274 LPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQFFHLN 332
+ + D + + G K L++G R P V TYEL++++F+++
Sbjct: 554 AGQTTYSGVI-DCFRKILREEG-PKALWKGAGARVFRSSPQFGVTLLTYELLQRWFYID 610
Score = 70.1 bits (170), Expect = 3e-12
Identities = 55/213 (25%), Positives = 88/213 (41%), Gaps = 32/213 (15%)
Query: 125 LGISGHVHRLMAGSMAGMTAVICTYPLDMVRVRLAFQ-----VKGEHSYTGIIHAFKTIY 179
L ++ +R GS+AG YP+D+V+ R+ Q GE Y FK +
Sbjct: 323 LQVAESAYRFGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVL 382
Query: 180 AKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLK 239
E GFFG YRGL+P +LG+AP + ++ + + S +
Sbjct: 383 RYE-GFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRD-------KFMHKDGS-------VP 427
Query: 240 THVNLLCGGVAGAIAQTISYPFDVTRRRMQLG---TVLPEFEKCLTMRDTMKYVYGHHGI 296
+L GG AG + P ++ + R+Q+ T P +RD +
Sbjct: 428 LAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALSVVRDLGFF------- 480
Query: 297 RKGLYRGLSLNYIRCIPSQAVAFTTYELMKQFF 329
G+Y+G ++R IP A+ F Y +K F
Sbjct: 481 --GIYKGAKACFLRDIPFSAIYFPCYAHVKASF 511
>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
sapiens]
Length = 676
Score = 96.3 bits (238), Expect = 3e-20
Identities = 79/299 (26%), Positives = 132/299 (44%), Gaps = 26/299 (8%)
Query: 40 FLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGV------FSALRAVPQKEGFLGLY 93
F G +AG T V P+D VK +Q +G F + V + EGF GLY
Sbjct: 333 FGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLY 392
Query: 94 KGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDM 153
+G ++ + P AI+ + + K G ++AG AG + VI T PL++
Sbjct: 393 RGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPLEI 452
Query: 154 VRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTL 213
V++RL QV GE + + A + ++ GFFG Y+G L P++ + F + +
Sbjct: 453 VKIRL--QVAGEITTGPRVSALSVV--RDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHV 508
Query: 214 KSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTV 273
K+ + +P L LL G +AG A ++ P DV + R+Q+
Sbjct: 509 KA-------SFANEDGQVSPGSL-------LLAGAIAGMPAASLVTPADVIKTRLQVAAR 554
Query: 274 LPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQFFHLN 332
+ + D + + G K L++G R P V TYEL++++F+++
Sbjct: 555 AGQTTYSGVI-DCFRKILREEG-PKALWKGAGARVFRSSPQFGVTLLTYELLQRWFYID 611
Score = 70.1 bits (170), Expect = 3e-12
Identities = 55/213 (25%), Positives = 88/213 (41%), Gaps = 32/213 (15%)
Query: 125 LGISGHVHRLMAGSMAGMTAVICTYPLDMVRVRLAFQ-----VKGEHSYTGIIHAFKTIY 179
L ++ +R GS+AG YP+D+V+ R+ Q GE Y FK +
Sbjct: 324 LQVAESAYRFGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVL 383
Query: 180 AKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLK 239
E GFFG YRGL+P +LG+AP + ++ + + S +
Sbjct: 384 RYE-GFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRD-------KFMHKDGS-------VP 428
Query: 240 THVNLLCGGVAGAIAQTISYPFDVTRRRMQLG---TVLPEFEKCLTMRDTMKYVYGHHGI 296
+L GG AG + P ++ + R+Q+ T P +RD +
Sbjct: 429 LAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALSVVRDLGFF------- 481
Query: 297 RKGLYRGLSLNYIRCIPSQAVAFTTYELMKQFF 329
G+Y+G ++R IP A+ F Y +K F
Sbjct: 482 --GIYKGAKACFLRDIPFSAIYFPCYAHVKASF 512
>gi|157388925 solute carrier family 25, member 38 [Homo sapiens]
Length = 304
Score = 94.7 bits (234), Expect = 1e-19
Identities = 79/296 (26%), Positives = 132/296 (44%), Gaps = 34/296 (11%)
Query: 37 LRSFLAGGIAGCCAKTTVAPLDRVKVLLQA---HNHHYKHLGVFSALRAVPQKEGFLGLY 93
+++FL G I+G C+ PLD +K LQ +H + +G+ + L V + E LGL+
Sbjct: 28 IKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGLW 87
Query: 94 KGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGH----VHRLMAGSMAGMTAVICTY 149
KG ++R P I F K + GH + +M G + A +C
Sbjct: 88 KGMSPSIVRCVPGVGIYFGTLYSLKQYF-----LRGHPPTALESVMLGVGSRSVAGVCMS 142
Query: 150 PLDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFT 209
P+ +++ R G++ Y I A ++IY E G G + GL T+L AP++G+
Sbjct: 143 PITVIKTRYE---SGKYGYESIYAALRSIYHSE-GHRGLFSGLTATLLRDAPFSGIYLMF 198
Query: 210 FGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQ 269
+ K++ P L+ T N CG AG +A ++ P DV + MQ
Sbjct: 199 YNQTKNI----------VPHDQVDATLIPIT--NFSCGIFAGILASLVTQPADVIKTHMQ 246
Query: 270 LGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELM 325
L + K + + ++ +G+R G ++G +R A+A+T YE M
Sbjct: 247 LYPL-----KFQWIGQAVTLIFKDYGLR-GFFQGGIPRALRRTLMAAMAWTVYEEM 296
Score = 42.4 bits (98), Expect = 6e-04
Identities = 29/111 (26%), Positives = 52/111 (46%), Gaps = 5/111 (4%)
Query: 222 PTLLGRPSSDNPNVLVLKTHVNL---LCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFE 278
P+LL +P V L H + LCG ++G + + P D+ + R+Q
Sbjct: 7 PSLL-QPQDVGDTVETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGS 65
Query: 279 KCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQFF 329
+ + M + V + GL++G+S + +RC+P + F T +KQ+F
Sbjct: 66 RRVGMLAVLLKVVRTESLL-GLWKGMSPSIVRCVPGVGIYFGTLYSLKQYF 115
>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
Length = 678
Score = 92.0 bits (227), Expect = 6e-19
Identities = 83/318 (26%), Positives = 139/318 (43%), Gaps = 26/318 (8%)
Query: 21 QAAGAGGPTTRRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGV---- 76
Q+ G G P + F G +AG T V P+D VK +Q +G
Sbjct: 311 QSPGLGRPIWLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYK 370
Query: 77 --FSALRAVPQKEGFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRL 134
F + V + EGF GLY+G +I + P AI+ + + T + G +
Sbjct: 371 NSFDCFKKVLRYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEV 430
Query: 135 MAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMP 194
+AG AG + VI T PL++V++RL QV GE + + A + ++ G FG Y+G
Sbjct: 431 LAGGCAGGSQVIFTNPLEIVKIRL--QVAGEITTGPRVSALNVL--RDLGIFGLYKGAKA 486
Query: 195 TILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIA 254
L P++ + F + +H LL + +N +V L L G +AG A
Sbjct: 487 CFLRDIPFSAIYFPVY--------AHCKLLL---ADENGHVGGLNL---LAAGAMAGVPA 532
Query: 255 QTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPS 314
++ P DV + R+Q+ + + D + + G ++G + R P
Sbjct: 533 ASLVTPADVIKTRLQVAARAGQTTYSGVI-DCFRKILREEG-PSAFWKGTAARVFRSSPQ 590
Query: 315 QAVAFTTYELMKQFFHLN 332
V TYEL++++F+++
Sbjct: 591 FGVTLVTYELLQRWFYID 608
>gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo
sapiens]
Length = 325
Score = 90.1 bits (222), Expect = 2e-18
Identities = 80/298 (26%), Positives = 133/298 (44%), Gaps = 25/298 (8%)
Query: 38 RSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNH-------HYKHLGVFSALRAVPQKEGFL 90
+ F+ GG+A A+ P+D K LQ K+ G+F AL + ++EG L
Sbjct: 42 KPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVL 101
Query: 91 GLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYP 150
LY G ++R YG I+ ++ K L +L + ++ G ++G+ + P
Sbjct: 102 ALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANP 161
Query: 151 LDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTF 210
D++++R+ Q +G +I +F IY +E G G +RG++PT A GV +
Sbjct: 162 TDVLKIRM--QAQGSLFQGSMIGSFIDIYQQE-GTRGLWRGVVPTAQRAAIVVGVELPVY 218
Query: 211 GTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTR-RRMQ 269
K +L D +L V+ G+AGA+A S P DV R R M
Sbjct: 219 DITKK------HLILSGMMGDT----ILTHFVSSFTCGLAGALA---SNPVDVVRTRMMN 265
Query: 270 LGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQ 327
++ + D + ++ H G LY+G N++R P + F TYE +K+
Sbjct: 266 QRAIVGHVDLYKGTVDGILKMWKHEGF-FALYKGFWPNWLRLGPWNIIFFITYEQLKR 322
Score = 52.4 bits (124), Expect = 6e-07
Identities = 42/183 (22%), Positives = 83/183 (45%), Gaps = 8/183 (4%)
Query: 37 LRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGN 96
L + + G ++G + T P D +K+ +QA ++ + + + Q+EG GL++G
Sbjct: 142 LINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQG-SMIGSFIDIYQQEGTRGLWRGV 200
Query: 97 GAMMIRIFPYGAIQFMAFEHYK--TLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMV 154
R ++ ++ K +++ +G + H ++ G+ + + P+D+V
Sbjct: 201 VPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTH-FVSSFTCGLAGALASNPVDVV 259
Query: 155 RVRLAFQ---VKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFG 211
R R+ Q V Y G + ++ K GFF Y+G P L + P+ + F T+
Sbjct: 260 RTRMMNQRAIVGHVDLYKGTVDGILKMW-KHEGFFALYKGFWPNWLRLGPWNIIFFITYE 318
Query: 212 TLK 214
LK
Sbjct: 319 QLK 321
Score = 33.9 bits (76), Expect = 0.21
Identities = 23/81 (28%), Positives = 36/81 (44%), Gaps = 7/81 (8%)
Query: 44 GIAGCCAKTTVAPLDRVKVLLQAHNHHYKHL----GVFSALRAVPQKEGFLGLYKGNGAM 99
G+AG A P+D V+ + H+ G + + + EGF LYKG
Sbjct: 246 GLAGALASN---PVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPN 302
Query: 100 MIRIFPYGAIQFMAFEHYKTL 120
+R+ P+ I F+ +E K L
Sbjct: 303 WLRLGPWNIIFFITYEQLKRL 323
>gi|13259543 solute carrier family 25, member 14 isoform UCP5S [Homo
sapiens]
Length = 322
Score = 90.1 bits (222), Expect = 2e-18
Identities = 80/298 (26%), Positives = 133/298 (44%), Gaps = 25/298 (8%)
Query: 38 RSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNH-------HYKHLGVFSALRAVPQKEGFL 90
+ F+ GG+A A+ P+D K LQ K+ G+F AL + ++EG L
Sbjct: 39 KPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVL 98
Query: 91 GLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYP 150
LY G ++R YG I+ ++ K L +L + ++ G ++G+ + P
Sbjct: 99 ALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANP 158
Query: 151 LDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTF 210
D++++R+ Q +G +I +F IY +E G G +RG++PT A GV +
Sbjct: 159 TDVLKIRM--QAQGSLFQGSMIGSFIDIYQQE-GTRGLWRGVVPTAQRAAIVVGVELPVY 215
Query: 211 GTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTR-RRMQ 269
K +L D +L V+ G+AGA+A S P DV R R M
Sbjct: 216 DITKK------HLILSGMMGDT----ILTHFVSSFTCGLAGALA---SNPVDVVRTRMMN 262
Query: 270 LGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQ 327
++ + D + ++ H G LY+G N++R P + F TYE +K+
Sbjct: 263 QRAIVGHVDLYKGTVDGILKMWKHEGF-FALYKGFWPNWLRLGPWNIIFFITYEQLKR 319
Score = 52.4 bits (124), Expect = 6e-07
Identities = 42/183 (22%), Positives = 83/183 (45%), Gaps = 8/183 (4%)
Query: 37 LRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGN 96
L + + G ++G + T P D +K+ +QA ++ + + + Q+EG GL++G
Sbjct: 139 LINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQG-SMIGSFIDIYQQEGTRGLWRGV 197
Query: 97 GAMMIRIFPYGAIQFMAFEHYK--TLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMV 154
R ++ ++ K +++ +G + H ++ G+ + + P+D+V
Sbjct: 198 VPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTH-FVSSFTCGLAGALASNPVDVV 256
Query: 155 RVRLAFQ---VKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFG 211
R R+ Q V Y G + ++ K GFF Y+G P L + P+ + F T+
Sbjct: 257 RTRMMNQRAIVGHVDLYKGTVDGILKMW-KHEGFFALYKGFWPNWLRLGPWNIIFFITYE 315
Query: 212 TLK 214
LK
Sbjct: 316 QLK 318
Score = 33.9 bits (76), Expect = 0.21
Identities = 23/81 (28%), Positives = 36/81 (44%), Gaps = 7/81 (8%)
Query: 44 GIAGCCAKTTVAPLDRVKVLLQAHNHHYKHL----GVFSALRAVPQKEGFLGLYKGNGAM 99
G+AG A P+D V+ + H+ G + + + EGF LYKG
Sbjct: 243 GLAGALASN---PVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPN 299
Query: 100 MIRIFPYGAIQFMAFEHYKTL 120
+R+ P+ I F+ +E K L
Sbjct: 300 WLRLGPWNIIFFITYEQLKRL 320
>gi|86198310 solute carrier family 25, member 29 [Homo sapiens]
Length = 303
Score = 89.7 bits (221), Expect = 3e-18
Identities = 84/286 (29%), Positives = 125/286 (43%), Gaps = 26/286 (9%)
Query: 40 FLAGGIAGCCAKTTVAPLDRVKVLLQAHN-HHYKHLGVFSALRAVPQKEGFLGLYKGNGA 98
FLAG G P D VKV LQ + ++ G +++ ++E LGLYKG G+
Sbjct: 5 FLAGCAGGVAGVLVGHPFDTVKVRLQVQSVEKPQYRGTLHCFKSIIKQESVLGLYKGLGS 64
Query: 99 MMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMVRVRL 158
++ + A+ F TL LG +++ +AG+ AG + P+++ + RL
Sbjct: 65 PLMGLTFINALVFGV--QGNTL--RALGHDSPLNQFLAGAAAGAIQCVICCPMELAKTRL 120
Query: 159 AFQVKGE-HSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVG 217
Q G +Y G + IY EG G RG++ T+L P GV F T+ L
Sbjct: 121 QLQDAGPARTYKGSLDCLAQIYGHEG-LRGVNRGMVSTLLRETPSFGVYFLTYDALTRA- 178
Query: 218 LSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTV--LP 275
LG D +LV K LL GG +G ++ +YP DV + R+Q + P
Sbjct: 179 -------LGCEPGDR--LLVPKL---LLAGGTSGIVSWLSTYPVDVVKSRLQADGLRGAP 226
Query: 276 EFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTT 321
+ L D + Y G R RGL+ +R P A F T
Sbjct: 227 RYRGIL---DCVHQSYRAEGWRV-FTRGLASTLLRAFPVNAATFAT 268
Score = 75.5 bits (184), Expect = 6e-14
Identities = 58/192 (30%), Positives = 88/192 (45%), Gaps = 23/192 (11%)
Query: 135 MAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMP 194
+AG G+ V+ +P D V+VRL Q + Y G +H FK+I K+ G Y+GL
Sbjct: 6 LAGCAGGVAGVLVGHPFDTVKVRLQVQSVEKPQYRGTLHCFKSI-IKQESVLGLYKGLGS 64
Query: 195 TILGMAPYAGVSFFTFG-TLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAI 253
++G+ + F G TL+++G D+P L G AGAI
Sbjct: 65 PLMGLTFINALVFGVQGNTLRALG------------HDSP-------LNQFLAGAAAGAI 105
Query: 254 AQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIP 313
I P ++ + R+QL P D + +YGH G+R G+ RG+ +R P
Sbjct: 106 QCVICCPMELAKTRLQLQDAGPA-RTYKGSLDCLAQIYGHEGLR-GVNRGMVSTLLRETP 163
Query: 314 SQAVAFTTYELM 325
S V F TY+ +
Sbjct: 164 SFGVYFLTYDAL 175
Score = 62.4 bits (150), Expect = 5e-10
Identities = 52/179 (29%), Positives = 82/179 (45%), Gaps = 9/179 (5%)
Query: 37 LRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHN----HHYKHLGVFSALRAVPQKEGFLGL 92
L FLAG AG P++ K LQ + YK G L + EG G+
Sbjct: 93 LNQFLAGAAAGAIQCVICCPMELAKTRLQLQDAGPARTYK--GSLDCLAQIYGHEGLRGV 150
Query: 93 YKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHR-LMAGSMAGMTAVICTYPL 151
+G + ++R P + F+ ++ + + G V + L+AG +G+ + + TYP+
Sbjct: 151 NRGMVSTLLRETPSFGVYFLTYDALTRALGCEPGDRLLVPKLLLAGGTSGIVSWLSTYPV 210
Query: 152 DMVRVRL-AFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFT 209
D+V+ RL A ++G Y GI+ Y E G+ F RGL T+L P +F T
Sbjct: 211 DVVKSRLQADGLRGAPRYRGILDCVHQSYRAE-GWRVFTRGLASTLLRAFPVNAATFAT 268
>gi|157388989 solute carrier family 25, member 36 isoform a [Homo
sapiens]
Length = 311
Score = 89.0 bits (219), Expect = 5e-18
Identities = 80/310 (25%), Positives = 132/310 (42%), Gaps = 42/310 (13%)
Query: 42 AGGIAGCCAKTTVAPLDRVKVLLQAHN------------------HHYKHLGVFSALRAV 83
AGG G PL+ VK LQ+ + + G L+ +
Sbjct: 12 AGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPLHCLKVI 71
Query: 84 PQKEGFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMT 143
+KEG L++G G ++ + P AI F A+ + K + +++ +MAG T
Sbjct: 72 LEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVFDPDSTQVHMISAAMAGFT 131
Query: 144 AVICTYPLDMVRVRLAFQVKGE-HSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPY 202
A+ T P+ +++ RL + G + +Y +G GFYRG+ A Y
Sbjct: 132 AITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDG-LKGFYRGMS------ASY 184
Query: 203 AGVS-----FFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNL-LCGGVAGAIAQT 256
AG+S F + ++K L + +D +V V + L + A T
Sbjct: 185 AGISETVIHFVIYESIKQKLLEYKTA--STMENDEESVKEASDFVGMMLAAATSKTCATT 242
Query: 257 ISYPFDVTRRRM-QLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQ 315
I+YP +V R R+ + GT F + L++ + YG LYRGL+ + +R IP+
Sbjct: 243 IAYPHEVVRTRLREEGTKYRSFFQTLSLL-VQEEGYG------SLYRGLTTHLVRQIPNT 295
Query: 316 AVAFTTYELM 325
A+ TYEL+
Sbjct: 296 AIMMATYELV 305
Score = 35.0 bits (79), Expect = 0.093
Identities = 27/103 (26%), Positives = 43/103 (41%), Gaps = 16/103 (15%)
Query: 240 THVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFEKCL--TMRDT----------- 286
T V+L GG G + ++ P +V + R+Q +V + TM
Sbjct: 6 TLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPL 65
Query: 287 --MKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQ 327
+K + G R L+RGL N + PS+A+ F Y K+
Sbjct: 66 HCLKVILEKEGPR-SLFRGLGPNLVGVAPSRAIYFAAYSNCKE 107
>gi|21389315 solute carrier family 25 (mitochondrial carrier;
citrate transporter), member 1 precursor [Homo sapiens]
Length = 311
Score = 88.2 bits (217), Expect = 9e-18
Identities = 87/319 (27%), Positives = 131/319 (41%), Gaps = 32/319 (10%)
Query: 15 PPPAMPQAAGAGGPTTRRD--FYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQA--HNHH 70
P P P+A A P + + + ++ LAGG+AG P + VK LQ +H
Sbjct: 2 PAPRAPRALAAAAPASGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHP 61
Query: 71 YKHLGVFSALRAVPQKEGFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGH 130
++ G+ +R + G LGLY+G +++ P A++F FE + G
Sbjct: 62 PRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDS 121
Query: 131 VHRLMAGSMAGMT-AVICTYPLDMVRVRLAF-QVKGEHSYTGIIHAFKTIYAKEGGFFGF 188
L+ G AG+ AV+ P++ ++V+ Q Y G H + I +E G G
Sbjct: 122 TRGLLCGLGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREI-VREQGLKGT 180
Query: 189 YRGLMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGG 248
Y+GL T+L + FF +L++ DNPN +N L G
Sbjct: 181 YQGLTATVLKQGSNQAIRFFVMTSLRN-----------WYRGDNPN-----KPMNPLITG 224
Query: 249 VAGAIAQTISY----PFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGL 304
V GAIA S P DV + RMQ G E K D + G+ K Y+G
Sbjct: 225 VFGAIAGAASVFGNTPLDVIKTRMQ-GL---EAHKYRNTWDCGLQILKKEGL-KAFYKGT 279
Query: 305 SLNYIRCIPSQAVAFTTYE 323
R A+ F Y+
Sbjct: 280 VPRLGRVCLDVAIVFVIYD 298
Score = 46.6 bits (109), Expect = 3e-05
Identities = 51/206 (24%), Positives = 79/206 (38%), Gaps = 35/206 (16%)
Query: 134 LMAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHS-YTGIIHAFKTIYAKEGGFFGFYRGL 192
++AG +AG + T+P + V+ +L + Y GI + + G G YRGL
Sbjct: 29 ILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQT-VRSHGVLGLYRGL 87
Query: 193 MPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAG- 251
+ G P A V F F L + H GR S LLCG AG
Sbjct: 88 SSLLYGSIPKAAVRFGMFEFLSN----HMRDAQGRLDSTR----------GLLCGLGAGV 133
Query: 252 AIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIR--------KGLYRG 303
A A + P + + + P KY HG+R KG Y+G
Sbjct: 134 AEAVVVVCPMETIKVKFIHDQTSPN----------PKYRGFFHGVREIVREQGLKGTYQG 183
Query: 304 LSLNYIRCIPSQAVAFTTYELMKQFF 329
L+ ++ +QA+ F ++ ++
Sbjct: 184 LTATVLKQGSNQAIRFFVMTSLRNWY 209
Score = 32.0 bits (71), Expect = 0.79
Identities = 22/79 (27%), Positives = 35/79 (44%), Gaps = 1/79 (1%)
Query: 43 GGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAMMIR 102
G IAG + PLD +K +Q H K+ + + +KEG YKG + R
Sbjct: 227 GAIAGAASVFGNTPLDVIKTRMQGLEAH-KYRNTWDCGLQILKKEGLKAFYKGTVPRLGR 285
Query: 103 IFPYGAIQFMAFEHYKTLI 121
+ AI F+ ++ L+
Sbjct: 286 VCLDVAIVFVIYDEVVKLL 304
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.327 0.140 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,307,959
Number of Sequences: 37866
Number of extensions: 532947
Number of successful extensions: 3346
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 2568
Number of HSP's gapped (non-prelim): 283
length of query: 332
length of database: 18,247,518
effective HSP length: 103
effective length of query: 229
effective length of database: 14,347,320
effective search space: 3285536280
effective search space used: 3285536280
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.