Guide to the Human Genome
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Search of human proteins with 24041029

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24041029 nitric oxide synthase 2A [Homo sapiens]
         (1153 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|24041029 nitric oxide synthase 2A [Homo sapiens]                  2377   0.0  
gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]         1232   0.0  
gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens]         1158   0.0  
gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens]         637   0.0  
gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens]         637   0.0  
gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens]         636   0.0  
gi|127139033 cytochrome P450 reductase [Homo sapiens]                 258   3e-68
gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b [...   191   4e-48
gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens]   188   3e-47
gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens]   188   3e-47
gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a...   187   6e-47
gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c...   183   7e-46
gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d...   176   1e-43
gi|50726981 radical S-adenosyl methionine and flavodoxin domains...    37   0.11 
gi|18496983 CAP-GLY domain containing linker protein 3 [Homo sap...    33   1.2  
gi|19923669 sel-1 suppressor of lin-12-like [Homo sapiens]             32   4.5  
gi|224282123 tRNA-yW synthesizing protein 1 homolog B isoform 1 ...    32   4.5  
gi|157426896 tripartite motif-containing 10 isoform 2 [Homo sapi...    32   4.5  
gi|29570798 phosphoribosyl pyrophosphate amidotransferase propro...    31   7.8  
gi|68348723 zinc finger protein 711 [Homo sapiens]                     31   7.8  

>gi|24041029 nitric oxide synthase 2A [Homo sapiens]
          Length = 1153

 Score = 2377 bits (6160), Expect = 0.0
 Identities = 1153/1153 (100%), Positives = 1153/1153 (100%)

Query: 1    MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPL 60
            MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPL
Sbjct: 1    MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPL 60

Query: 61   VETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIM 120
            VETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIM
Sbjct: 61   VETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIM 120

Query: 121  TPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ 180
            TPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ
Sbjct: 121  TPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ 180

Query: 181  LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNI 240
            LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNI
Sbjct: 181  LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNI 240

Query: 241  RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG 300
            RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG
Sbjct: 241  RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG 300

Query: 301  RFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVG 360
            RFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVG
Sbjct: 301  RFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVG 360

Query: 361  GLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINI 420
            GLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINI
Sbjct: 361  GLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINI 420

Query: 421  AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEM 480
            AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEM
Sbjct: 421  AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEM 480

Query: 481  LNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVT 540
            LNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVT
Sbjct: 481  LNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVT 540

Query: 541  ILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPG 600
            ILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPG
Sbjct: 541  ILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPG 600

Query: 601  NGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGD 660
            NGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGD
Sbjct: 601  NGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGD 660

Query: 661  ELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDL 720
            ELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDL
Sbjct: 661  ELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDL 720

Query: 721  SKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQ 780
            SKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQ
Sbjct: 721  SKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQ 780

Query: 781  PALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQ 840
            PALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQ
Sbjct: 781  PALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQ 840

Query: 841  LLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQL 900
            LLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQL
Sbjct: 841  LLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQL 900

Query: 901  PILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCF 960
            PILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCF
Sbjct: 901  PILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCF 960

Query: 961  VRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPD 1020
            VRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPD
Sbjct: 961  VRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPD 1020

Query: 1021 EDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLY 1080
            EDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLY
Sbjct: 1021 EDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLY 1080

Query: 1081 VCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDR 1140
            VCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDR
Sbjct: 1081 VCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDR 1140

Query: 1141 VAVQPSSLEMSAL 1153
            VAVQPSSLEMSAL
Sbjct: 1141 VAVQPSSLEMSAL 1153


>gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]
          Length = 1434

 Score = 1232 bits (3187), Expect = 0.0
 Identities = 615/1133 (54%), Positives = 779/1133 (68%), Gaps = 58/1133 (5%)

Query: 49   LSKQQNESPQPLVETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGIL 108
            L+   +E  QP   +GK+SP      + +P   PR +++KNW + +   DTLH K+    
Sbjct: 275  LNNPYSEKEQPPT-SGKQSPTK----NGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLET 329

Query: 109  TCRSKSCLGSIMTPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEA 168
             C    C+GSIM P    R P D  T   +L P A EF++QYY S K    + H+ R+E 
Sbjct: 330  GCTEYICMGSIMHPSQHARRPEDVRTK-GQLFPLAKEFIDQYYSSIKRFGSKAHMERLEE 388

Query: 169  VTKEIETTGTYQLTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHIC 228
            V KEI+TT TYQL   ELI+  K AWRNA RC+GRIQWS LQVFDAR C+TA  MF +IC
Sbjct: 389  VNKEIDTTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYIC 448

Query: 229  RHVRYSTNNGNIRSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQ 288
             HV+Y+TN GN+RSAIT+FPQR+DGKHDFRVWN+QLIRYAGY+ PDGS  GDPANV+FT+
Sbjct: 449  NHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTE 508

Query: 289  LCIDLGWKPKYGRFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYA 348
            +CI  GWKP  GRFDV+PL+LQANG DPELF+IPP+LVLEV + HPK+EWF++L LKWY 
Sbjct: 509  ICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYG 568

Query: 349  LPAVANMLLEVGGLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLAS 408
            LPAV+NMLLE+GGLEF  CPF+GWYMGTEIGVRD+CD  RYNILEEV ++M L+  K +S
Sbjct: 569  LPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSS 628

Query: 409  LWKDQAVVEINIAVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPM 468
            LWKDQA+VEINIAVL+SFQ   VTI+DHHSA ESF+K+M+NEYR RGGCPADW+W+VPPM
Sbjct: 629  LWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPM 688

Query: 469  SGSITPVFHQEMLNYVLSPFYYYQVEAWKTHVWQDEKRRP-KRREIPLKVLVKAVLFACM 527
            SGSITPVFHQEMLNY L+P + YQ + W THVW+     P KRR I  K L +AV F+  
Sbjct: 689  SGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAK 748

Query: 528  LMRKTMASRVRVTILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLL 587
            LM + MA RV+ TIL+ATETGKS+A A  L  +F  AF+ KV+ M++Y +  LE E L+L
Sbjct: 749  LMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVL 808

Query: 588  VVTSTFGNGDCPGNGEKLKKSLFMLKELNN------------------------------ 617
            VVTSTFGNGD P NGEK   +L  ++  N+                              
Sbjct: 809  VVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPD 868

Query: 618  ------------KFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGDELSGQ 665
                          R++VFGLGS  YP FCAF H +D  L  LG  ++  M EGDEL GQ
Sbjct: 869  LRDNFESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQ 928

Query: 666  EDAFRSWAVQTFKAACETFDVRGKQHIQIP--KLYTSNVTWDPHHYRLVQDSQPLDLSKA 723
            E+AFR+WA + FKAAC+ F V    +I+     L +++ +W  + +RL   ++  +L++ 
Sbjct: 929  EEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPELTQG 988

Query: 724  LSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQPAL 783
            LS++H K V   RL SRQNLQSP SSR+TI V L     Q L Y PG+HLGV PGN   L
Sbjct: 989  LSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDL 1048

Query: 784  VQGILERVVDGPTPHQTVRLEALDESG------SYWVSDKRLPPCSLSQALTYFLDITTP 837
            V  ++ER+ D P  +Q V++E L+E        S W  + RLPPC++ QA  Y+LDITTP
Sbjct: 1049 VNALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLPPCTIFQAFKYYLDITTP 1108

Query: 838  PTQLLLQKLAQVATEEPERQRLEALCQP-SEYSKWKFTNSPTFLEVLEEFPSLRVSAGFL 896
            PT L LQ+ A +AT E E+QRL  L +   EY +WK+  +PT +EVLEEFPS+++ A  L
Sbjct: 1109 PTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPATLL 1168

Query: 897  LSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDP 956
            L+QL +L+PR+YSISSS D  P E+HLTVA+V+Y TRDG+GP+HHGVCS+WLN ++  + 
Sbjct: 1169 LTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQADEL 1228

Query: 957  VPCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGC 1016
            VPCFVR A  FHLP +P  PCIL+GPGTGIAPFRSFWQQR  D QHKG+    M LVFGC
Sbjct: 1229 VPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGC 1288

Query: 1017 RRPDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEP 1076
            R+   DHIY+EE L+   KGV   ++TAYSR P KPK YVQDIL++QLA  V R L ++ 
Sbjct: 1289 RQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVYRALKEQG 1348

Query: 1077 GHLYVCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFG 1129
            GH+YVCGDV MA DV   +++++  + KL+ E    +  +++   RYHEDIFG
Sbjct: 1349 GHIYVCGDVTMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHEDIFG 1401


>gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens]
          Length = 1203

 Score = 1158 bits (2996), Expect = 0.0
 Identities = 578/1123 (51%), Positives = 744/1123 (66%), Gaps = 54/1123 (4%)

Query: 78   PLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIMTPKSLTRGPRDKPTPPD 137
            P   P+  R+KNW  G    DTL  +A+    C  + CLGS++ P+ L   P   P  P+
Sbjct: 62   PPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAPE 121

Query: 138  ELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQLTGDELIFATKQAWRNA 197
            +LL QA +F+NQYY S K +  + H  R++ V  E+  TGTYQL   EL+F  KQAWRNA
Sbjct: 122  QLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNA 181

Query: 198  PRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNIRSAITVFPQRSDGKHDF 257
            PRC+GRIQW  LQVFDAR C +A+EMF +IC H++Y+TN GN+RSAITVFPQR  G+ DF
Sbjct: 182  PRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDF 241

Query: 258  RVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYGRFDVVPLVLQANGRDPE 317
            R+WN+QL+RYAGY+  DGS+RGDPANVE T+LCI  GW P  GRFDV+PL+LQA    PE
Sbjct: 242  RIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDDPPE 301

Query: 318  LFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVGGLEFPGCPFNGWYMGTE 377
            LF +PP+LVLEV +EHP  EWF  L L+WYALPAV+NMLLE+GGLEFP  PF+GWYM TE
Sbjct: 302  LFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTE 361

Query: 378  IGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINIAVLHSFQKQNVTIMDHH 437
            IG R+ CD  RYNILE+V   M L+T   +SLWKD+A VEIN+AVLHS+Q   VTI+DHH
Sbjct: 362  IGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHH 421

Query: 438  SAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEMLNYVLSPFYYYQVEAWK 497
            +A  SFMK+++NE ++RGGCPADW W+VPP+SGS+TPVFHQEM+NY LSP + YQ + WK
Sbjct: 422  AATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWK 481

Query: 498  THVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVTILFATETGKSEALAWDL 557
                   K     R+   K +  AV  +  LM   MA RV+ TIL+ +ETG++++ A  L
Sbjct: 482  GSA---AKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQL 538

Query: 558  GALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPGNGEKLKKSLFML----- 612
            G LF  AF+P+V+CMD+Y +  LE E L+LVVTSTFGNGD P NGE    +L  +     
Sbjct: 539  GRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYN 598

Query: 613  --------------------------------KELNN--------KFRYAVFGLGSSMYP 632
                                            KE +N          R+ VFGLGS  YP
Sbjct: 599  SSPRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYP 658

Query: 633  RFCAFAHDIDQKLSHLGASQLTPMGEGDELSGQEDAFRSWAVQTFKAACETFDVRGKQHI 692
             FCAFA  +D +L  LG  +L  +G+GDEL GQE+AFR WA   F+AACETF V      
Sbjct: 659  HFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKA 718

Query: 693  QIPKLYTSNVTWDPHHYRLVQDSQPLDLSKALSSMHAKNVFTMRLKSRQNLQSPTSSRAT 752
                +++   +W    YRL   ++ L L   L  +H + +F   ++S +NLQS  S+RAT
Sbjct: 719  AARDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATIRSVENLQSSKSTRAT 778

Query: 753  ILVELSCEDGQGLNYLPGEHLGVCPGNQPALVQGILERVVDGPTPHQTVRLEALDESG-- 810
            ILV L     +GL Y PG+H+GVCP N+P LV+ +L RV D P P + V +E L++    
Sbjct: 779  ILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPG 838

Query: 811  ---SYWVSDKRLPPCSLSQALTYFLDITTPPTQLLLQKLAQVATEEPERQRLEALCQ-PS 866
                 WV D RLPPC+L QALT+FLDIT+PP+  LL+ L+ +A E  E+Q LEAL Q P 
Sbjct: 839  GPPPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPR 898

Query: 867  EYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVA 926
             Y +WK+   PT LEVLE+FPS+ + A  LL+QLP+L+PR+YS+SS+    P EIHLTVA
Sbjct: 899  RYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVA 958

Query: 927  VVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCFVRNASGFHLPEDPSHPCILIGPGTGI 986
            V+ Y T+DG GPLH+GVCSTWL+ LKP DPVPCF+R A  F LP DPS PCIL+GPGTGI
Sbjct: 959  VLAYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGI 1018

Query: 987  APFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPDEDHIYQEEMLEMAQKGVLHAVHTAYS 1046
            APFR FWQ+RLHD + KG++   MTLVFGCR    DH+Y++E+    Q+GV   V TA+S
Sbjct: 1019 APFRGFWQERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFS 1078

Query: 1047 RLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLYVCGDVRMARDVAHTLKQLVAAKLKLN 1106
            R P  PK YVQDILR +LA+EV RVL  E GH++VCGDV MA +V  T+++++A +  + 
Sbjct: 1079 REPDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDME 1138

Query: 1107 EEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDRVAVQPSSLE 1149
             ++  D    L+ Q+RYHEDIFG     +    R+  Q  SL+
Sbjct: 1139 LDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQ 1181


>gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens]
          Length = 629

 Score =  637 bits (1642), Expect = 0.0
 Identities = 302/528 (57%), Positives = 380/528 (71%), Gaps = 3/528 (0%)

Query: 78  PLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIMTPKSLTRGPRDKPTPPD 137
           P   P+  R+KNW  G    DTL  +A+    C  + CLGS++ P+ L   P   P  P+
Sbjct: 62  PPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAPE 121

Query: 138 ELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQLTGDELIFATKQAWRNA 197
           +LL QA +F+NQYY S K +  + H  R++ V  E+  TGTYQL   EL+F  KQAWRNA
Sbjct: 122 QLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNA 181

Query: 198 PRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNIRSAITVFPQRSDGKHDF 257
           PRC+GRIQW  LQVFDAR C +A+EMF +IC H++Y+TN GN+RSAITVFPQR  G+ DF
Sbjct: 182 PRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDF 241

Query: 258 RVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYGRFDVVPLVLQANGRDPE 317
           R+WN+QL+RYAGY+  DGS+RGDPANVE T+LCI  GW P  GRFDV+PL+LQA    PE
Sbjct: 242 RIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDDPPE 301

Query: 318 LFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVGGLEFPGCPFNGWYMGTE 377
           LF +PP+LVLEV +EHP  EWF  L L+WYALPAV+NMLLE+GGLEFP  PF+GWYM TE
Sbjct: 302 LFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTE 361

Query: 378 IGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINIAVLHSFQKQNVTIMDHH 437
           IG R+ CD  RYNILE+V   M L+T   +SLWKD+A VEIN+AVLHS+Q   VTI+DHH
Sbjct: 362 IGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHH 421

Query: 438 SAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEMLNYVLSPFYYYQVEAWK 497
           +A  SFMK+++NE ++RGGCPADW W+VPP+SGS+TPVFHQEM+NY LSP + YQ + WK
Sbjct: 422 AATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWK 481

Query: 498 THVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVTILFATETGKSEALAWDL 557
                  K     R+   K +  AV  +  LM   MA RV+ TIL+ +ETG++++ A  L
Sbjct: 482 GSA---AKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQL 538

Query: 558 GALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPGNGEKL 605
           G LF  AF+P+V+CMD+Y +  LE E L+LVVTSTFGNGD P NGE L
Sbjct: 539 GRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGEGL 586


>gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens]
          Length = 614

 Score =  637 bits (1642), Expect = 0.0
 Identities = 301/527 (57%), Positives = 380/527 (72%), Gaps = 3/527 (0%)

Query: 78  PLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIMTPKSLTRGPRDKPTPPD 137
           P   P+  R+KNW  G    DTL  +A+    C  + CLGS++ P+ L   P   P  P+
Sbjct: 62  PPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAPE 121

Query: 138 ELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQLTGDELIFATKQAWRNA 197
           +LL QA +F+NQYY S K +  + H  R++ V  E+  TGTYQL   EL+F  KQAWRNA
Sbjct: 122 QLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNA 181

Query: 198 PRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNIRSAITVFPQRSDGKHDF 257
           PRC+GRIQW  LQVFDAR C +A+EMF +IC H++Y+TN GN+RSAITVFPQR  G+ DF
Sbjct: 182 PRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDF 241

Query: 258 RVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYGRFDVVPLVLQANGRDPE 317
           R+WN+QL+RYAGY+  DGS+RGDPANVE T+LCI  GW P  GRFDV+PL+LQA    PE
Sbjct: 242 RIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDDPPE 301

Query: 318 LFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVGGLEFPGCPFNGWYMGTE 377
           LF +PP+LVLEV +EHP  EWF  L L+WYALPAV+NMLLE+GGLEFP  PF+GWYM TE
Sbjct: 302 LFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTE 361

Query: 378 IGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINIAVLHSFQKQNVTIMDHH 437
           IG R+ CD  RYNILE+V   M L+T   +SLWKD+A VEIN+AVLHS+Q   VTI+DHH
Sbjct: 362 IGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHH 421

Query: 438 SAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEMLNYVLSPFYYYQVEAWK 497
           +A  SFMK+++NE ++RGGCPADW W+VPP+SGS+TPVFHQEM+NY LSP + YQ + WK
Sbjct: 422 AATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWK 481

Query: 498 THVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVTILFATETGKSEALAWDL 557
                  K     R+   K +  AV  +  LM   MA RV+ TIL+ +ETG++++ A  L
Sbjct: 482 GSA---AKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQL 538

Query: 558 GALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPGNGEK 604
           G LF  AF+P+V+CMD+Y +  LE E L+LVVTSTFGNGD P NGE+
Sbjct: 539 GRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGER 585


>gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens]
          Length = 596

 Score =  636 bits (1641), Expect = 0.0
 Identities = 301/528 (57%), Positives = 380/528 (71%), Gaps = 3/528 (0%)

Query: 78  PLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIMTPKSLTRGPRDKPTPPD 137
           P   P+  R+KNW  G    DTL  +A+    C  + CLGS++ P+ L   P   P  P+
Sbjct: 62  PPEGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPPAPE 121

Query: 138 ELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQLTGDELIFATKQAWRNA 197
           +LL QA +F+NQYY S K +  + H  R++ V  E+  TGTYQL   EL+F  KQAWRNA
Sbjct: 122 QLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNA 181

Query: 198 PRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNIRSAITVFPQRSDGKHDF 257
           PRC+GRIQW  LQVFDAR C +A+EMF +IC H++Y+TN GN+RSAITVFPQR  G+ DF
Sbjct: 182 PRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDF 241

Query: 258 RVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYGRFDVVPLVLQANGRDPE 317
           R+WN+QL+RYAGY+  DGS+RGDPANVE T+LCI  GW P  GRFDV+PL+LQA    PE
Sbjct: 242 RIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDDPPE 301

Query: 318 LFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVGGLEFPGCPFNGWYMGTE 377
           LF +PP+LVLEV +EHP  EWF  L L+WYALPAV+NMLLE+GGLEFP  PF+GWYM TE
Sbjct: 302 LFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTE 361

Query: 378 IGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINIAVLHSFQKQNVTIMDHH 437
           IG R+ CD  RYNILE+V   M L+T   +SLWKD+A VEIN+AVLHS+Q   VTI+DHH
Sbjct: 362 IGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHH 421

Query: 438 SAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEMLNYVLSPFYYYQVEAWK 497
           +A  SFMK+++NE ++RGGCPADW W+VPP+SGS+TPVFHQEM+NY LSP + YQ + WK
Sbjct: 422 AATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWK 481

Query: 498 THVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVTILFATETGKSEALAWDL 557
                  K     R+   K +  AV  +  LM   MA RV+ TIL+ +ETG++++ A  L
Sbjct: 482 GSA---AKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQL 538

Query: 558 GALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPGNGEKL 605
           G LF  AF+P+V+CMD+Y +  LE E L+LVVTSTFGNGD P NGE +
Sbjct: 539 GRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESV 586


>gi|127139033 cytochrome P450 reductase [Homo sapiens]
          Length = 680

 Score =  258 bits (658), Expect = 3e-68
 Identities = 207/651 (31%), Positives = 312/651 (47%), Gaps = 48/651 (7%)

Query: 507  RPKRREIP----LKVLVKAVLFACMLMRKTMASRVRVTILFATETGKSEALAWDLG---- 558
            R K+ E+P    ++ L  +V  +  + +     R  + + + ++TG +E  A  L     
Sbjct: 48   RKKKEEVPEFTKIQTLTSSVRESSFVEKMKKTGR-NIIVFYGSQTGTAEEFANRLSKDAH 106

Query: 559  --ALFSCAFNPKVVCMDKYRLSCLEEERLLLVV--TSTFGNGDCPGNGEKLKKSLFMLKE 614
               +   + +P+    D   LS L E    LVV   +T+G GD   N +     L     
Sbjct: 107  RYGMRGMSADPEEY--DLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDV 164

Query: 615  LNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGDELSGQEDAFRSWAV 674
              +  ++AVFGLG+  Y  F A    +D++L  LGA ++  +G GD+    E+ F +W  
Sbjct: 165  DLSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWRE 224

Query: 675  QTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLV--QDSQPLDLSKALSSMHAKNV 732
            Q + A CE F V         + Y   V  D    ++   +  +            AKN 
Sbjct: 225  QFWPAVCEHFGVEATGEESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNP 284

Query: 733  FTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQPALVQGILERVV 792
            F   + + + L   T  R  + +EL   D + + Y  G+H+ V P N  ALV  + +  +
Sbjct: 285  FLAAVTTNRKLNQGT-ERHLMHLELDISDSK-IRYESGDHVAVYPANDSALVNQLGK--I 340

Query: 793  DGPTPHQTVRLEALDESGSYWVSDKRLP---PCSLSQALTYFLDITTPPTQLLLQKLAQV 849
             G      + L  LDE      S+K+ P   P S   ALTY+LDIT PP   +L +LAQ 
Sbjct: 341  LGADLDVVMSLNNLDEE-----SNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQY 395

Query: 850  ATEEPERQRLEALCQPSE-----YSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQLPILK 904
            A+E  E++ L  +   S      Y  W        L +L++ PSLR     L   LP L+
Sbjct: 396  ASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQ 455

Query: 905  PRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDP------VP 958
             R+YSI+SS    P  +H+   VV Y T+ G+  ++ GV + WL + +P         VP
Sbjct: 456  ARYYSIASSSKVHPNSVHICAVVVEYETKAGR--INKGVATNWLRAKEPAGENGGRALVP 513

Query: 959  CFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRR 1018
             FVR  S F LP   + P I++GPGTG+APF  F Q+R    Q +G   G   L +GCRR
Sbjct: 514  MFVRK-SQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQ-QGKEVGETLLYYGCRR 571

Query: 1019 PDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGH 1078
             DED++Y+EE+ +  + G L  ++ A+SR     KVYVQ +L+Q    E L  L +   H
Sbjct: 572  SDEDYLYREELAQFHRDGALTQLNVAFSR-EQSHKVYVQHLLKQD--REHLWKLIEGGAH 628

Query: 1079 LYVCGDVR-MARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIF 1128
            +YVCGD R MARDV +T   +VA    +   Q  DY  +L ++ RY  D++
Sbjct: 629  IYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTKGRYSLDVW 679


>gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b [Homo
            sapiens]
          Length = 597

 Score =  191 bits (484), Expect = 4e-48
 Identities = 175/615 (28%), Positives = 292/615 (47%), Gaps = 51/615 (8%)

Query: 538  RVTILFATETGKSEALAWDLGA-----LFSCAFNPKVVCMDKYRLSCLEEERLLLVVTST 592
            ++ +LF ++TG ++ ++  LG         C    +V  +D Y +  L  E L++ V +T
Sbjct: 5    QLLVLFGSQTGTAQDVSERLGREARRRRLGC----RVQALDSYPVVNLINEPLVIFVCAT 60

Query: 593  FGNGDCPGNGEKLKKSLFMLKELNN----KFRYAVFGLGSSMYPRFCAFAHDIDQKLSHL 648
             G GD P N +   + +F  K L +    +  +AV GLG S Y +F   A  + ++L  L
Sbjct: 61   TGQGDPPDNMKNFWRFIFR-KNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQL 119

Query: 649  GASQLTPMGEGDELS--GQEDAFRSWAVQTFKAACETFD-----VRGKQHIQIPKLYTSN 701
            G S L P+  GD+    G + A   W    +      +            + +P  +T  
Sbjct: 120  GGSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFT-- 177

Query: 702  VTWDPHHYRLVQDSQPLDLSKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCED 761
            + +         + Q +    +         F   + S Q +  P+  +   L+E     
Sbjct: 178  LLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDIL- 236

Query: 762  GQGLNYLPGEHLGVCPGNQPALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLP- 820
            G G+++  G+ + + P N  A VQ   +  V G  P Q   L+  +   S   S  RLP 
Sbjct: 237  GSGISFAAGDVVLIQPSNSAAHVQRFCQ--VLGLDPDQLFMLQPREPDVS---SPTRLPQ 291

Query: 821  PCSLSQALTYFLDITTPPTQLLLQKLAQVATEEPERQRL-EALCQPSEYSKWKFTNSP-- 877
            PCS+   ++++LDI + P +   + LA ++  E ER++L E      +   +++ N P  
Sbjct: 292  PCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRR 351

Query: 878  TFLEVLEEFP--SLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDG 935
            T LEVL +FP  +  +   +LL  +P+++PR +SI+SS    P+ + + VAVV + TR  
Sbjct: 352  TILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLK 411

Query: 936  QGPLHHGVCSTWLNSLKP-QDPV--PCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSF 992
            +     G+CS+WL SL P Q PV  P +VR  S    PE P  P I++GPGTG+APFR+ 
Sbjct: 412  EP--RRGLCSSWLASLDPGQGPVRVPLWVRPGS-LAFPETPDTPVIMVGPGTGVAPFRAA 468

Query: 993  WQQRLHDSQHKGVRGGRMTLVFGCRRPDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKP 1052
             Q+R+   Q          L FGCR  D+D  ++ E  E+ ++  L  +  A+SR   + 
Sbjct: 469  IQERVAQGQTGNF------LFFGCRWRDQDFYWEAEWQELEKRDCLTLI-PAFSR-EQEQ 520

Query: 1053 KVYVQDILRQQLASEVLRVLHKEPGHLYVCGDVR-MARDVAHTLKQLVAAKLKLNEEQVE 1111
            KVYVQ  LR +L S V  +L ++  + Y+ G+ + M  DV+  L  +   +  L      
Sbjct: 521  KVYVQHRLR-ELGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAA 579

Query: 1112 DYFFQLKSQKRYHED 1126
             Y  +L+  +R+  +
Sbjct: 580  AYLARLQQTRRFQTE 594


>gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens]
          Length = 698

 Score =  188 bits (477), Expect = 3e-47
 Identities = 138/459 (30%), Positives = 221/459 (48%), Gaps = 33/459 (7%)

Query: 701  NVTWDPHHYRLVQDSQPLDLSKA-LSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSC 759
            N+   P  Y  V   + L   ++ +S   A  VF + +     L +  + + T+LVEL  
Sbjct: 241  NIPGLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDI 300

Query: 760  EDGQGLNYLPGEHLGVCPGNQPALVQGILERV-VDGPTPHQTVRLEALDESGSYWVSDKR 818
             +    +Y PG+   V   N  + VQ +L+R+ ++    H  +     D         + 
Sbjct: 301  SNTD-FSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKGATLPQH 359

Query: 819  LPP-CSLSQALTYFLDITTPPTQLLLQKLAQVATEEPERQRLEALCQP---SEYSKWKFT 874
            +P  CSL    T+ L+I   P +  L+ L    ++  E++RL+ LC     ++YS++   
Sbjct: 360  IPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRD 419

Query: 875  NSPTFLEVLEEFPSLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRD 934
                 L++L  FPS +     LL  LP L+PR YS +SS    P ++H    +V + +  
Sbjct: 420  ACACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTA 479

Query: 935  GQGPLHHGVCSTWL-----NSLKPQ-------------DPVPCFVRNASGFHLPEDPSHP 976
                L  GVC+ WL     + L+P                +    R  + FHLP+DPS P
Sbjct: 480  TTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIP 539

Query: 977  CILIGPGTGIAPFRSFWQQRLH-DSQHKGVRGGRMTLVFGCRRPDEDHIYQEEMLEMAQK 1035
             I++GPGTGIAPF  F Q R     QH     G M L FGCR  D D+++++E+    + 
Sbjct: 540  IIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKH 599

Query: 1036 GVLHAVHTAYSR-----LPGKPKVYVQDILRQQLASEVLRVLHKEPGHLYVCGDVR-MAR 1089
            G+L  +  ++SR         P  YVQD + Q    +V R+L +E GH+YVCGD + MA+
Sbjct: 600  GILTHLKVSFSRDAPVGEEEAPAKYVQDNI-QLHGQQVARILLQENGHIYVCGDAKNMAK 658

Query: 1090 DVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIF 1128
            DV   L Q+++ ++ + + +       LK +KRY +DI+
Sbjct: 659  DVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIW 697



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 52/169 (30%), Positives = 76/169 (44%), Gaps = 22/169 (13%)

Query: 538 RVTILFATETGKSEALAWDL-GALFSCAFNPKVVCM---DKYRLSCLEEERLLLVVTSTF 593
           R  +L+AT+ G+++A+A ++        F+  + C+   DKY L    E   L+VV ST 
Sbjct: 3   RFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKT--ETAPLVVVVSTT 60

Query: 594 GNGDCPGNGEKLKKSLFMLKELNNK---------FRYAVFGLGSSMYPRFCAFAHDIDQK 644
           G GD P    K       +KE+ N+          RY + GLG S Y  FC     ID++
Sbjct: 61  GTGDPPDTARKF------VKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKR 114

Query: 645 LSHLGASQLTPMGEGDELSGQEDAFRSWAVQTFKAACETF-DVRGKQHI 692
           L  LGA      G  D+  G E     W    + A  + F   RG++ I
Sbjct: 115 LQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEI 163


>gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens]
          Length = 725

 Score =  188 bits (477), Expect = 3e-47
 Identities = 138/459 (30%), Positives = 221/459 (48%), Gaps = 33/459 (7%)

Query: 701  NVTWDPHHYRLVQDSQPLDLSKA-LSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSC 759
            N+   P  Y  V   + L   ++ +S   A  VF + +     L +  + + T+LVEL  
Sbjct: 268  NIPGLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDI 327

Query: 760  EDGQGLNYLPGEHLGVCPGNQPALVQGILERV-VDGPTPHQTVRLEALDESGSYWVSDKR 818
             +    +Y PG+   V   N  + VQ +L+R+ ++    H  +     D         + 
Sbjct: 328  SNTD-FSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKGATLPQH 386

Query: 819  LPP-CSLSQALTYFLDITTPPTQLLLQKLAQVATEEPERQRLEALCQP---SEYSKWKFT 874
            +P  CSL    T+ L+I   P +  L+ L    ++  E++RL+ LC     ++YS++   
Sbjct: 387  IPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRD 446

Query: 875  NSPTFLEVLEEFPSLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRD 934
                 L++L  FPS +     LL  LP L+PR YS +SS    P ++H    +V + +  
Sbjct: 447  ACACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTA 506

Query: 935  GQGPLHHGVCSTWL-----NSLKPQ-------------DPVPCFVRNASGFHLPEDPSHP 976
                L  GVC+ WL     + L+P                +    R  + FHLP+DPS P
Sbjct: 507  TTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIP 566

Query: 977  CILIGPGTGIAPFRSFWQQRLH-DSQHKGVRGGRMTLVFGCRRPDEDHIYQEEMLEMAQK 1035
             I++GPGTGIAPF  F Q R     QH     G M L FGCR  D D+++++E+    + 
Sbjct: 567  IIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKH 626

Query: 1036 GVLHAVHTAYSR-----LPGKPKVYVQDILRQQLASEVLRVLHKEPGHLYVCGDVR-MAR 1089
            G+L  +  ++SR         P  YVQD + Q    +V R+L +E GH+YVCGD + MA+
Sbjct: 627  GILTHLKVSFSRDAPVGEEEAPAKYVQDNI-QLHGQQVARILLQENGHIYVCGDAKNMAK 685

Query: 1090 DVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIF 1128
            DV   L Q+++ ++ + + +       LK +KRY +DI+
Sbjct: 686  DVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIW 724



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 52/169 (30%), Positives = 76/169 (44%), Gaps = 22/169 (13%)

Query: 538 RVTILFATETGKSEALAWDL-GALFSCAFNPKVVCM---DKYRLSCLEEERLLLVVTSTF 593
           R  +L+AT+ G+++A+A ++        F+  + C+   DKY L    E   L+VV ST 
Sbjct: 30  RFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKT--ETAPLVVVVSTT 87

Query: 594 GNGDCPGNGEKLKKSLFMLKELNNK---------FRYAVFGLGSSMYPRFCAFAHDIDQK 644
           G GD P    K       +KE+ N+          RY + GLG S Y  FC     ID++
Sbjct: 88  GTGDPPDTARKF------VKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKR 141

Query: 645 LSHLGASQLTPMGEGDELSGQEDAFRSWAVQTFKAACETF-DVRGKQHI 692
           L  LGA      G  D+  G E     W    + A  + F   RG++ I
Sbjct: 142 LQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEI 190


>gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a
            [Homo sapiens]
          Length = 606

 Score =  187 bits (474), Expect = 6e-47
 Identities = 175/623 (28%), Positives = 292/623 (46%), Gaps = 58/623 (9%)

Query: 538  RVTILFATETGKSEALAWDLGA-----LFSCAFNPKVVCMDKYRLSCLEEERLLLVVTST 592
            ++ +LF ++TG ++ ++  LG         C    +V  +D Y +  L  E L++ V +T
Sbjct: 5    QLLVLFGSQTGTAQDVSERLGREARRRRLGC----RVQALDSYPVVNLINEPLVIFVCAT 60

Query: 593  FGNGDCPGNGEKLKKSLFMLKELNN----KFRYAVFGLGSSMYPRFCAFAHDIDQKLSHL 648
             G GD P N +   + +F  K L +    +  +AV GLG S Y +F   A  + ++L  L
Sbjct: 61   TGQGDPPDNMKNFWRFIFR-KNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQL 119

Query: 649  GASQLTPMGEGDELS--GQEDAFRSWAVQTFKAACETFD-----VRGKQHIQIPKLYTSN 701
            G S L P+  GD+    G + A   W    +      +            + +P  +T  
Sbjct: 120  GGSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFT-- 177

Query: 702  VTWDPHHYRLVQDSQPLDLSKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCED 761
            + +         + Q +    +         F   + S Q +  P+  +   L+E     
Sbjct: 178  LLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDIL- 236

Query: 762  GQGLNYLPGEHLGVCPGNQPALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLP- 820
            G G+++  G+ + + P N  A VQ   +  V G  P Q   L+  +   S   S  RLP 
Sbjct: 237  GSGISFAAGDVVLIQPSNSAAHVQRFCQ--VLGLDPDQLFMLQPREPDVS---SPTRLPQ 291

Query: 821  PCSLSQALTYFLDITTPPTQLLLQKLAQVATEEPERQRL-EALCQPSEYSKWKFTNSP-- 877
            PCS+   ++++LDI + P +   + LA ++  E ER++L E      +   +++ N P  
Sbjct: 292  PCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRR 351

Query: 878  TFLEVLEEFP--SLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDG 935
            T LEVL +FP  +  +   +LL  +P+++PR +SI+SS    P+ + + VAVV + TR  
Sbjct: 352  TILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLK 411

Query: 936  QGPLHHGVCSTWLNSLKP-QDPV--PCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSF 992
            +     G+CS+WL SL P Q PV  P +VR  S    PE P  P I++GPGTG+APFR+ 
Sbjct: 412  EP--RRGLCSSWLASLDPGQGPVRVPLWVRPGS-LAFPETPDTPVIMVGPGTGVAPFRAA 468

Query: 993  WQQRLHDSQHKGVRGGRMTLVFGCRRPDEDHIYQEEMLEMAQKGVLHAVHTAYSR----- 1047
             Q+R+   Q          L FGCR  D+D  ++ E  E+ ++  L  +  A+SR     
Sbjct: 469  IQERVAQGQTGNF------LFFGCRWRDQDFYWEAEWQELEKRDCLTLI-PAFSREQPPA 521

Query: 1048 ---LPGKPKVYVQDILRQQLASEVLRVLHKEPGHLYVCGDVR-MARDVAHTLKQLVAAKL 1103
                  + KVYVQ  LR +L S V  +L ++  + Y+ G+ + M  DV+  L  +   + 
Sbjct: 522  LFSALQEQKVYVQHRLR-ELGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEG 580

Query: 1104 KLNEEQVEDYFFQLKSQKRYHED 1126
             L       Y  +L+  +R+  +
Sbjct: 581  GLCSPDAAAYLARLQQTRRFQTE 603


>gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c
            [Homo sapiens]
          Length = 590

 Score =  183 bits (465), Expect = 7e-46
 Identities = 174/615 (28%), Positives = 290/615 (47%), Gaps = 58/615 (9%)

Query: 538  RVTILFATETGKSEALAWDLGA-----LFSCAFNPKVVCMDKYRLSCLEEERLLLVVTST 592
            ++ +LF ++TG ++ ++  LG         C    +V  +D Y +  L  E L++ V +T
Sbjct: 5    QLLVLFGSQTGTAQDVSERLGREARRRRLGC----RVQALDSYPVVNLINEPLVIFVCAT 60

Query: 593  FGNGDCPGNGEKLKKSLFMLKELNN----KFRYAVFGLGSSMYPRFCAFAHDIDQKLSHL 648
             G GD P N +   + +F  K L +    +  +AV GLG S Y +F   A  + ++L  L
Sbjct: 61   TGQGDPPDNMKNFWRFIFR-KNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQL 119

Query: 649  GASQLTPMGEGDELS--GQEDAFRSWAVQTFKAACETFD-----VRGKQHIQIPKLYTSN 701
            G S L P+  GD+    G + A   W    +      +            + +P  +T  
Sbjct: 120  GGSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFT-- 177

Query: 702  VTWDPHHYRLVQDSQPLDLSKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCED 761
            + +         + Q +    +         F   + S Q +  P+  +   L+E     
Sbjct: 178  LLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDIL- 236

Query: 762  GQGLNYLPGEHLGVCPGNQPALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLP- 820
            G G+++  G+ + + P N  A VQ   +  V G  P Q   L+  +   S   S  RLP 
Sbjct: 237  GSGISFAAGDVVLIQPSNSAAHVQRFCQ--VLGLDPDQLFMLQPREPDVS---SPTRLPQ 291

Query: 821  PCSLSQALTYFLDITTPPTQLLLQKLAQVATEEPERQRL-EALCQPSEYSKWKFTNSP-- 877
            PCS+   ++++LDI + P +   + LA ++  E ER++L E      +   +++ N P  
Sbjct: 292  PCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRR 351

Query: 878  TFLEVLEEFP--SLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDG 935
            T LEVL +FP  +  +   +LL  +P+++PR +SI+SS       + + VAVV + TR  
Sbjct: 352  TILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASS-------LLILVAVVQFQTRLK 404

Query: 936  QGPLHHGVCSTWLNSLKP-QDPV--PCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSF 992
            +     G+CS+WL SL P Q PV  P +VR  S    PE P  P I++GPGTG+APFR+ 
Sbjct: 405  EP--RRGLCSSWLASLDPGQGPVRVPLWVRPGS-LAFPETPDTPVIMVGPGTGVAPFRAA 461

Query: 993  WQQRLHDSQHKGVRGGRMTLVFGCRRPDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKP 1052
             Q+R+   Q          L FGCR  D+D  ++ E  E+ ++  L  +  A+SR   + 
Sbjct: 462  IQERVAQGQTGNF------LFFGCRWRDQDFYWEAEWQELEKRDCLTLI-PAFSR-EQEQ 513

Query: 1053 KVYVQDILRQQLASEVLRVLHKEPGHLYVCGDVR-MARDVAHTLKQLVAAKLKLNEEQVE 1111
            KVYVQ  LR +L S V  +L ++  + Y+ G+ + M  DV+  L  +   +  L      
Sbjct: 514  KVYVQHRLR-ELGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAA 572

Query: 1112 DYFFQLKSQKRYHED 1126
             Y  +L+  +R+  +
Sbjct: 573  AYLARLQQTRRFQTE 587


>gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d
            [Homo sapiens]
          Length = 521

 Score =  176 bits (446), Expect = 1e-43
 Identities = 166/556 (29%), Positives = 265/556 (47%), Gaps = 70/556 (12%)

Query: 538  RVTILFATETGKSEALAWDLGA-----LFSCAFNPKVVCMDKYRLSCLEEERLLLVVTST 592
            ++ +LF ++TG ++ ++  LG         C    +V  +D Y +  L  E L++ V +T
Sbjct: 5    QLLVLFGSQTGTAQDVSERLGREARRRRLGC----RVQALDSYPVVNLINEPLVIFVCAT 60

Query: 593  FGNGDCPGNGEKLKKSLFMLKELNN----KFRYAVFGLGSSMYPRFCAFAHDIDQKLSHL 648
             G GD P N +   + +F  K L +    +  +AV GLG S Y +F   A  + ++L  L
Sbjct: 61   TGQGDPPDNMKNFWRFIFR-KNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQL 119

Query: 649  GASQLTPMGEGDELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHH 708
            G S L P+  GD+    E    S     F     +    G++               P  
Sbjct: 120  GGSALLPVCLGDDQ--HELGLPSKFTLLFLQEAPSTGSEGQRVAH------------PGS 165

Query: 709  YRLVQDSQPLDLSKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYL 768
                 +S+P               F   + S Q +  P+  +   L+E     G G+++ 
Sbjct: 166  QEPPSESKP---------------FLAPMISNQRVTGPSHFQDVRLIEFDIL-GSGISFA 209

Query: 769  PGEHLGVCPGNQPALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLP-PCSLSQA 827
             G+ + + P N  A VQ   +  V G  P Q   L+  +   S   S  RLP PCS+   
Sbjct: 210  AGDVVLIQPSNSAAHVQRFCQ--VLGLDPDQLFMLQPREPDVS---SPTRLPQPCSMRHL 264

Query: 828  LTYFLDITTPPTQLLLQKLAQVATEEPERQRL-EALCQPSEYSKWKFTNSP--TFLEVLE 884
            ++++LDI + P +   + LA ++  E ER++L E      +   +++ N P  T LEVL 
Sbjct: 265  VSHYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLC 324

Query: 885  EFP--SLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHG 942
            +FP  +  +   +LL  +P+++PR +SI+SS    P+ + + VAVV + TR  +     G
Sbjct: 325  DFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEP--RRG 382

Query: 943  VCSTWLNSLKP-QDPV--PCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHD 999
            +CS+WL SL P Q PV  P +VR  S    PE P  P I++GPGTG+APFR+  Q+R+  
Sbjct: 383  LCSSWLASLDPGQGPVRVPLWVRPGS-LAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQ 441

Query: 1000 SQHKGVRGGRMTLVFGCRRPDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDI 1059
             Q          L FGCR  D+D  ++ E  E+ ++  L  +  A+SR   + KVYVQ  
Sbjct: 442  GQTGNF------LFFGCRWRDQDFYWEAEWQELEKRDCLTLI-PAFSR-EQEQKVYVQHR 493

Query: 1060 LRQQLASEVLRVLHKE 1075
            LR +L S V  +L ++
Sbjct: 494  LR-ELGSLVWELLDRQ 508


>gi|50726981 radical S-adenosyl methionine and flavodoxin domains 1
           [Homo sapiens]
          Length = 732

 Score = 37.0 bits (84), Expect = 0.11
 Identities = 24/60 (40%), Positives = 32/60 (53%), Gaps = 7/60 (11%)

Query: 620 RYAVFGLGSSMY-PRFCAFAHDIDQKLSHLGASQLTPMGEGD------ELSGQEDAFRSW 672
           RYAVFGLG+S Y   F     ++D+ L  LGA ++   GEGD      +    E  FR+W
Sbjct: 173 RYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAW 232


>gi|18496983 CAP-GLY domain containing linker protein 3 [Homo sapiens]
          Length = 547

 Score = 33.5 bits (75), Expect = 1.2
 Identities = 28/89 (31%), Positives = 34/89 (38%)

Query: 953  PQDPVPCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTL 1012
            P  P P     A  F  P DP+   IL  P T I    +  +Q +   QHK    G   L
Sbjct: 45   PSAPAPLPKDYAFTFFDPNDPACQEILFDPQTTIPELFAIVRQWVPQVQHKIDVIGNEIL 104

Query: 1013 VFGCRRPDEDHIYQEEMLEMAQKGVLHAV 1041
              GC   D D +    +L  A K   H V
Sbjct: 105  RRGCHVNDRDGLTDMTLLHYACKAGAHGV 133


>gi|19923669 sel-1 suppressor of lin-12-like [Homo sapiens]
          Length = 794

 Score = 31.6 bits (70), Expect = 4.5
 Identities = 17/58 (29%), Positives = 29/58 (50%), Gaps = 6/58 (10%)

Query: 215 RSCSTAREMFEHICRHVRYSTNNGNIRSAITVFPQRSDGKHDFRVWNAQLIRYAGYQM 272
           RSC TA E+F+++C   R+S         +T +    DG ++  V    L+   GY++
Sbjct: 537 RSCHTAVELFKNVCERGRWS------ERLMTAYNSYKDGDYNAAVIQYLLLAEQGYEV 588


>gi|224282123 tRNA-yW synthesizing protein 1 homolog B isoform 1
           [Homo sapiens]
          Length = 668

 Score = 31.6 bits (70), Expect = 4.5
 Identities = 22/60 (36%), Positives = 30/60 (50%), Gaps = 7/60 (11%)

Query: 620 RYAVFGLGSSMY-PRFCAFAHDIDQKLSHLGASQLTPMGEGD------ELSGQEDAFRSW 672
           R AVFGLG+S Y   F     ++D+ L  LG  ++   GEGD      +    E  FR+W
Sbjct: 127 RDAVFGLGNSAYASHFNKVGKNVDKWLWMLGVHRVMSRGEGDCDVVKSKHGSIEANFRAW 186


>gi|157426896 tripartite motif-containing 10 isoform 2 [Homo sapiens]
          Length = 395

 Score = 31.6 bits (70), Expect = 4.5
 Identities = 23/75 (30%), Positives = 31/75 (41%), Gaps = 12/75 (16%)

Query: 959  CFVRNASGFHLPEDP--SHPCILIGPGTGIAPFRSFWQQRLHDSQ----------HKGVR 1006
            CF  +    H+  DP  SHP +L+      A F   WQ    + Q          H G+ 
Sbjct: 302  CFELDYEPAHISLDPQTSHPKLLLSEDHQRAQFSYKWQNSPDNPQRFDRATCVLAHTGIT 361

Query: 1007 GGRMTLVFGCRRPDE 1021
            GGR T V+  R P +
Sbjct: 362  GGRHTWVWMARVPGD 376


>gi|29570798 phosphoribosyl pyrophosphate amidotransferase
           proprotein [Homo sapiens]
          Length = 517

 Score = 30.8 bits (68), Expect = 7.8
 Identities = 13/42 (30%), Positives = 25/42 (59%)

Query: 163 LARVEAVTKEIETTGTYQLTGDELIFATKQAWRNAPRCIGRI 204
           +AR++ + KE  T  +  +   ++I+A +  + N P CIGR+
Sbjct: 170 VARIKNLMKEAPTAYSLLIMHRDVIYAVRDPYGNRPLCIGRL 211


>gi|68348723 zinc finger protein 711 [Homo sapiens]
          Length = 761

 Score = 30.8 bits (68), Expect = 7.8
 Identities = 20/63 (31%), Positives = 29/63 (46%), Gaps = 2/63 (3%)

Query: 640 DIDQKLSHLGASQLTPMGEGDELSGQEDAFRSWAVQT--FKAACETFDVRGKQHIQIPKL 697
           D+ +KL H+G + L    +G +   +ED F S  ++   FKA  E     G   I     
Sbjct: 210 DVGEKLEHMGNTPLKIGSDGSQEDAKEDGFGSEVIKVYIFKAEAEDDVEIGGTEIVTESE 269

Query: 698 YTS 700
           YTS
Sbjct: 270 YTS 272


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,056,117
Number of Sequences: 37866
Number of extensions: 2308429
Number of successful extensions: 5231
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 5149
Number of HSP's gapped (non-prelim): 34
length of query: 1153
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1040
effective length of database: 13,968,660
effective search space: 14527406400
effective search space used: 14527406400
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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