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Search of human proteins with 239753123
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo
sapiens]
(875 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 1774 0.0
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 1774 0.0
gi|239747686 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 1416 0.0
gi|40018614 DRE1 protein [Homo sapiens] 364 e-100
gi|55925608 kelch-like 21 [Homo sapiens] 310 3e-84
gi|166235129 kelch-like 3 [Homo sapiens] 294 2e-79
gi|38194229 kelch-like 17 [Homo sapiens] 290 3e-78
gi|194097389 kelch-like 38 [Homo sapiens] 286 4e-77
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 275 1e-73
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 275 1e-73
gi|11056006 kelch-like 12 [Homo sapiens] 274 2e-73
gi|109150407 kelch-like 6 [Homo sapiens] 272 9e-73
gi|40807500 kelch-like 20 [Homo sapiens] 267 3e-71
gi|55925604 kelch-like 18 [Homo sapiens] 265 1e-70
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 249 1e-65
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 249 1e-65
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 248 1e-65
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 247 3e-65
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 247 4e-65
gi|40255071 kelch-like 23 [Homo sapiens] 245 1e-64
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 239 1e-62
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 234 2e-61
gi|14780904 kelch-like 1 protein [Homo sapiens] 233 4e-61
gi|128485503 kelch-like 30 [Homo sapiens] 225 1e-58
gi|148664209 kelch-like 10 [Homo sapiens] 221 3e-57
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 211 2e-54
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 210 4e-54
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 207 3e-53
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 206 6e-53
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 206 8e-53
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 1774 bits (4595), Expect = 0.0
Identities = 875/875 (100%), Positives = 875/875 (100%)
Query: 1 MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVP 60
MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVP
Sbjct: 1 MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVP 60
Query: 61 SRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPI 120
SRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPI
Sbjct: 61 SRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPI 120
Query: 121 NQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQA 180
NQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQA
Sbjct: 121 NQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQA 180
Query: 181 PVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPG 240
PVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPG
Sbjct: 181 PVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPG 240
Query: 241 VGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIG 300
VGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIG
Sbjct: 241 VGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIG 300
Query: 301 VGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR 360
VGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR
Sbjct: 301 VGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR 360
Query: 361 SVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFC 420
SVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFC
Sbjct: 361 SVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFC 420
Query: 421 KVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDF 480
KVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDF
Sbjct: 421 KVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDF 480
Query: 481 IAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNE 540
IAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNE
Sbjct: 481 IAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNE 540
Query: 541 ELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQR 600
ELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQR
Sbjct: 541 ELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQR 600
Query: 601 SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL 660
SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL
Sbjct: 601 SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL 660
Query: 661 DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAV 720
DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAV
Sbjct: 661 DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAV 720
Query: 721 HSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFV 780
HSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFV
Sbjct: 721 HSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFV 780
Query: 781 FILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNM 840
FILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNM
Sbjct: 781 FILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNM 840
Query: 841 EAYEPTTNTWTLLPHMPCPVFRHGCVVIKKYIQSG 875
EAYEPTTNTWTLLPHMPCPVFRHGCVVIKKYIQSG
Sbjct: 841 EAYEPTTNTWTLLPHMPCPVFRHGCVVIKKYIQSG 875
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 1774 bits (4595), Expect = 0.0
Identities = 875/875 (100%), Positives = 875/875 (100%)
Query: 1 MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVP 60
MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVP
Sbjct: 1 MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVP 60
Query: 61 SRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPI 120
SRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPI
Sbjct: 61 SRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPI 120
Query: 121 NQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQA 180
NQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQA
Sbjct: 121 NQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQA 180
Query: 181 PVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPG 240
PVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPG
Sbjct: 181 PVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPG 240
Query: 241 VGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIG 300
VGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIG
Sbjct: 241 VGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIG 300
Query: 301 VGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR 360
VGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR
Sbjct: 301 VGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR 360
Query: 361 SVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFC 420
SVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFC
Sbjct: 361 SVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFC 420
Query: 421 KVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDF 480
KVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDF
Sbjct: 421 KVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDF 480
Query: 481 IAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNE 540
IAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNE
Sbjct: 481 IAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNE 540
Query: 541 ELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQR 600
ELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQR
Sbjct: 541 ELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQR 600
Query: 601 SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL 660
SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL
Sbjct: 601 SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL 660
Query: 661 DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAV 720
DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAV
Sbjct: 661 DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAV 720
Query: 721 HSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFV 780
HSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFV
Sbjct: 721 HSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFV 780
Query: 781 FILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNM 840
FILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNM
Sbjct: 781 FILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNM 840
Query: 841 EAYEPTTNTWTLLPHMPCPVFRHGCVVIKKYIQSG 875
EAYEPTTNTWTLLPHMPCPVFRHGCVVIKKYIQSG
Sbjct: 841 EAYEPTTNTWTLLPHMPCPVFRHGCVVIKKYIQSG 875
>gi|239747686 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 702
Score = 1416 bits (3666), Expect = 0.0
Identities = 702/702 (100%), Positives = 702/702 (100%)
Query: 1 MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVP 60
MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVP
Sbjct: 1 MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVP 60
Query: 61 SRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPI 120
SRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPI
Sbjct: 61 SRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPI 120
Query: 121 NQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQA 180
NQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQA
Sbjct: 121 NQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQA 180
Query: 181 PVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPG 240
PVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPG
Sbjct: 181 PVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPG 240
Query: 241 VGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIG 300
VGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIG
Sbjct: 241 VGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIG 300
Query: 301 VGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR 360
VGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR
Sbjct: 301 VGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR 360
Query: 361 SVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFC 420
SVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFC
Sbjct: 361 SVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFC 420
Query: 421 KVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDF 480
KVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDF
Sbjct: 421 KVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDF 480
Query: 481 IAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNE 540
IAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNE
Sbjct: 481 IAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNE 540
Query: 541 ELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQR 600
ELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQR
Sbjct: 541 ELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQR 600
Query: 601 SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL 660
SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL
Sbjct: 601 SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL 660
Query: 661 DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER 702
DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER
Sbjct: 661 DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER 702
Score = 33.9 bits (76), Expect = 0.68
Identities = 19/59 (32%), Positives = 28/59 (47%), Gaps = 2/59 (3%)
Query: 809 HSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVV 867
+ R+F S V IY +GG+ S G L ++ Y + W L+ M P RH +V
Sbjct: 624 YDREFFSVVSAGDNIYLSGGMES--GVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV 680
Score = 32.0 bits (71), Expect = 2.6
Identities = 28/106 (26%), Positives = 44/106 (41%), Gaps = 8/106 (7%)
Query: 732 IYVFGGVNEAG---RAAGVLQSYVPQTNTWSFIES-PMIDNKYAPAVTLNGFVFILGGAY 787
I + GG G R+ + + PQ N W + S P D ++ V+ +++ GG
Sbjct: 586 IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGME 645
Query: 788 ARATTI----YDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGI 829
+ T Y N M R +++V DGKIY GG+
Sbjct: 646 SGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGL 691
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 364 bits (935), Expect = e-100
Identities = 211/572 (36%), Positives = 317/572 (55%), Gaps = 19/572 (3%)
Query: 304 YEFTD----PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQ 359
+EF D H +L+ N+ R ++ FTD+ I VEG+EF H+ VL++CS YF+ +
Sbjct: 37 HEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFC 96
Query: 360 RSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTF 419
++S RE L + ++ + A+ +E L++VYTG + I + N + L E +S FQ
Sbjct: 97 NDHRES----REML-VEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVL 151
Query: 420 CKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDD 479
C FLE+QL NCLG+ A+ L+ K FALQ F +V+ EE L + KD+
Sbjct: 152 RDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDE 211
Query: 480 FIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDN 539
I Y+ +D L EE+V+E V++W+ + R ELL VRLP +HP+Y + V+
Sbjct: 212 LIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEV 271
Query: 540 EELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQ 599
++LI++S C L++EA+RYH+L + EM +PRTRPR S G +EVIV+VGG + VG
Sbjct: 272 DQLIQNSPECYQLLHEARRYHILGN---EMMSPRTRPRRSTGYSEVIVVVGGCERVG--G 326
Query: 600 RSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSL 659
+L C++P +W LA LP + + ++V + ++I +SGG + DVW Y S
Sbjct: 327 FNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGR---INSRDVWIYNSQ 383
Query: 660 LDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKA 719
L+ W V+ + R RH V GK+Y +GG + VE YD+ +N+W VAPL +A
Sbjct: 384 LNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEA 443
Query: 720 VHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGF 779
V S A T C GK++V GG + + +QSY P+TN+W + I + AV+LN
Sbjct: 444 VSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNL 503
Query: 780 VFILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGN 839
+++ GG +A YDP + N ++ C V +GKIY GG G A
Sbjct: 504 IYVAGG-LTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGG-RRENGEATDT 561
Query: 840 MEAYEPTTNTWTLLPHMPCPVFRHGCVVIKKY 871
+ Y+P T+ T + MP PV HGCV I +Y
Sbjct: 562 ILCYDPATSIITGVAAMPRPVSYHGCVTIHRY 593
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 310 bits (795), Expect = 3e-84
Identities = 194/569 (34%), Positives = 299/569 (52%), Gaps = 28/569 (4%)
Query: 306 FTDPGHPREMLKELNQQRRAKAFTDLKI-VVEGREFEVHQNVLASCSLYFKDLIQRSVQD 364
F+DP H +L+ L+Q R + F D+ + GR+F H+ VLA+ S YF+ +
Sbjct: 12 FSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMF------ 65
Query: 365 SGQGGREKLELV-LSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
+GQ + E V L + D+L+LLL+F YTG + + NA+ LL AA QF + C
Sbjct: 66 AGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEAC 125
Query: 424 VSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQE-EILSISKDDFIA 482
+FL++QL +NCL + AEA CS L A+ F L+ E+ A++ E L +++ +
Sbjct: 126 GAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLAR--LLR 183
Query: 483 YVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEEL 542
Y+ +D L EE Y+ ++W++ DP R + +LL VRLPF+ YLL V+ E L
Sbjct: 184 YLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPL 243
Query: 543 IKSSEACRDLVNEAKRYHMLPHARQEM-QTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRS 601
+ C L+ EA+ + + R + PR RPR S G+AE++VLVGG
Sbjct: 244 VARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGG---CDQDCDE 300
Query: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLD 661
LV V C+NPQ +W LA P + +S+V+ G++IY++GG + VW Y S ++
Sbjct: 301 LVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVN 360
Query: 662 NWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVH 721
W V+ M R H+S V DG +Y + D ERYD T+ WEA+ P+ +
Sbjct: 361 EWAEVAPMLKAREYHSSSVLDGLLYVVA-------ADSTERYDHTTDSWEALQPMTYPMD 413
Query: 722 SAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDN-KYAP-AVTLNGF 779
+ + T C G++Y G + AG+ V+Q Y P T+ WS ++ + +AP TLNG
Sbjct: 414 NCSTTACRGRLYAIGSL--AGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGL 471
Query: 780 VFILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGN 839
++ + A +Y+P + P+MN S VL GK+Y +GG +
Sbjct: 472 MYFVRDDSAE-VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGG-YDNTFELSDV 529
Query: 840 MEAYEPTTNTWTLLPHMPCPVFRHGCVVI 868
+EAY+P T W+++ +P P F HG V I
Sbjct: 530 VEAYDPETRAWSVVGRLPEPTFWHGSVSI 558
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 294 bits (753), Expect = 2e-79
Identities = 176/553 (31%), Positives = 280/553 (50%), Gaps = 19/553 (3%)
Query: 308 DPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQ 367
+P H + K +N+ R + D+ IV E E E H+ VLA+CS YF + D +
Sbjct: 29 NPAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMF---TGDMSE 85
Query: 368 GGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
+K+E+ ++ L L++++YT + + N + LL AAS Q + C FL
Sbjct: 86 SKAKKIEI--KDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFL 143
Query: 428 EKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSND 487
+ QL +NCLG+ A A+ C++L A A+A Q FPEV EE LS+S D + +S+D
Sbjct: 144 QSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSD 203
Query: 488 SLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSE 547
L +EE V+E VI WI + TR ++ A+L+ VRLP + YL+ V+ E LIK++
Sbjct: 204 KLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNN 263
Query: 548 ACRDLVNEAKRYHMLP-HARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVT 606
C+D + EA +YH+LP R ++ PRT+PR + +V+++VGG+ +++ +V
Sbjct: 264 TCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQ-----APKAIRSVE 318
Query: 607 CWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLV 666
C++ + ++W +A LP R VV ++Y GG + + V Y + D W +
Sbjct: 319 CYDFEEDRWDQIAELP-SRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSI 377
Query: 667 SRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAAT 726
+ M R + V + +Y +GG + + VE Y TN+W VAP+ S
Sbjct: 378 ASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVG 437
Query: 727 VCGGKIYVFGGVNEAGR-AAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG 785
V GK+Y GG + A R ++ Y P TN W ++ A L+G ++ GG
Sbjct: 438 VVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGG 497
Query: 786 ----AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNME 841
++ +YDP K +MN R+ ++G +Y GG S L ++E
Sbjct: 498 HDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN--LASVE 555
Query: 842 AYEPTTNTWTLLP 854
Y P T+ WTLLP
Sbjct: 556 YYNPVTDKWTLLP 568
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 290 bits (743), Expect = 3e-78
Identities = 182/596 (30%), Positives = 274/596 (45%), Gaps = 18/596 (3%)
Query: 259 GPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIGVGKYEFTDPGHPREMLKE 318
GP PPPPP QP A P +Q+L G H +
Sbjct: 23 GPEAPPPPPPQPPAPEAERTRPRQARPAAPMEGAVQLLSREG-HSVAHNSKRHYHDAFVA 81
Query: 319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLS 378
+++ R+ D+ + V +E H+ VLASCS YF + + +S Q + L
Sbjct: 82 MSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQ-----THVTLH 136
Query: 379 NLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
++ L+ L++F YT +V+ N +TLL AAS Q + C FL QL SNCLG
Sbjct: 137 DIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLG 196
Query: 439 VLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVY 498
+ A+A CS+L A + LQ F +VA EE + + + VS+DSLN +EE VY
Sbjct: 197 IRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVY 256
Query: 499 ETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKR 558
V+ W+K D R Q+ L+ VRLP + +LL VD E L++ C+DL+ EA +
Sbjct: 257 RAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALK 316
Query: 559 YHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPL 618
+H+LP R + T RTRPR G V+ VGG + + ++ + ++W+ +
Sbjct: 317 FHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHG----DCEAYDTRTDRWHVV 372
Query: 619 ASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNS 678
AS+ R V + G+ +Y GG + LA V Y + + W M R
Sbjct: 373 ASMS-TRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGV 431
Query: 679 LVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGV 738
G +Y+ GG A ++ ERYD +T W +VA + G +Y GG
Sbjct: 432 AALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGY 491
Query: 739 NEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG----AYARATTIY 794
+ + A V + Y PQ N WS + S + A L G +++ GG + + Y
Sbjct: 492 DSSSHLATV-EKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERY 550
Query: 795 DPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTW 850
P+ G ++ MN R V +DG +YA GG + +L ++E Y P TN W
Sbjct: 551 SPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGG--NDGSSSLNSIEKYNPRTNKW 604
Score = 75.9 bits (185), Expect = 2e-13
Identities = 53/177 (29%), Positives = 77/177 (43%), Gaps = 9/177 (5%)
Query: 685 IYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRA 744
++ +GG + E YDT T++W VA + G ++Y GG +
Sbjct: 344 LFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDL 403
Query: 745 AGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYARATTI-----YDPEKG 799
A V +SY P TNTW S L+G ++ GG Y A+ + YDP G
Sbjct: 404 ATV-ESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGG-YDGASCLNSAERYDPLTG 461
Query: 800 NIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHM 856
+ M+ R++ LDG +YA GG SS L +E YEP N W+ + M
Sbjct: 462 TWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSH--LATVEKYEPQVNVWSPVASM 516
Score = 63.2 bits (152), Expect = 1e-09
Identities = 47/164 (28%), Positives = 72/164 (43%), Gaps = 7/164 (4%)
Query: 553 VNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRS--LVAVTCWNP 610
+N A+RY L + TR R V L G VG S L V + P
Sbjct: 450 LNSAERYDPLTGTWTSVAAMSTRRRY----VRVATLDGNLYAVGGYDSSSHLATVEKYEP 505
Query: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMT 670
Q N W P+AS+ R V +Y++GG + L V Y W V+ M
Sbjct: 506 QVNVWSPVASM-LSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMN 564
Query: 671 VPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVA 714
+ R H+ + DG +Y +GG + +++ +E+Y+ TN+W A +
Sbjct: 565 IRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAAS 608
>gi|194097389 kelch-like 38 [Homo sapiens]
Length = 581
Score = 286 bits (733), Expect = 4e-77
Identities = 185/580 (31%), Positives = 294/580 (50%), Gaps = 34/580 (5%)
Query: 306 FTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDS 365
F D ++L++LN R+++ TD+ I RE H+NVLAS S YF+ + S ++
Sbjct: 11 FKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREK 70
Query: 366 GQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVS 425
+ ++ L + L+ ++ +VYTG I + N ++EAAS QF + C S
Sbjct: 71 SEA-----KVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSS 125
Query: 426 FLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVS 485
+L+ QL SNCLG++ ++E + C L A+ AL FPEVAA ++ + + Y+
Sbjct: 126 YLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLG 185
Query: 486 NDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKS 545
+D L EE V+E ++ WIK D R +Y EL VRL +IHP++ + + N+ L++S
Sbjct: 186 DDGL-CGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQS 244
Query: 546 SEACRDLVNEAKRYHM------LPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQ 599
S AC+ ++ AKR +P + + P PR S + ++L+GGR+ T
Sbjct: 245 SPACQIILETAKRQMFSLCGTTVPDCKLLLHVP---PRNS--YQDFLILLGGRKDSQQTT 299
Query: 600 RSLVAVTCWNPQNNKWYPLASLP--FYDREFFSVVSAGDNIYLSGGM--ESGVTLA--DV 653
R V ++ Q +W LA LP Y S ++ +IY+ GGM SG +L +V
Sbjct: 300 RD---VLLYSKQTGQWQSLAKLPTRLYKA---SAITLHRSIYVLGGMAVSSGRSLVSHNV 353
Query: 654 WCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGN-VDHVERYDTITNQWEA 712
+ + L+ W L M V R H S + I+++GG+G + +ERYD+I N WE+
Sbjct: 354 YIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWES 413
Query: 713 VAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAP 772
+A +P V A V ++Y+FGG + ++Q Y N+W +E+ MI N AP
Sbjct: 414 MASMPVGVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAP 473
Query: 773 AVTLNGFVFILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGG---I 829
AV L + I+GG Y R YDP+ +M R A V+ K+Y TGG
Sbjct: 474 AVVLGERIVIVGG-YTRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLT 532
Query: 830 VSSEGPALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVIK 869
+ + Y+P T+TWT +P +F H C+ ++
Sbjct: 533 TDCNIEDSASFDCYDPETDTWTSQGQLPHKLFDHACLTLQ 572
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 275 bits (703), Expect = 1e-73
Identities = 168/552 (30%), Positives = 274/552 (49%), Gaps = 19/552 (3%)
Query: 308 DPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQ 367
+P H ++ K +N+ R D+ IV E E H+ VLA+CS YF + + +S
Sbjct: 39 NPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSES-- 96
Query: 368 GGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
R K + + + L +L+++VYT + + N + LL AA Q K C FL
Sbjct: 97 --RAK-RVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFL 153
Query: 428 EKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSND 487
E QL NCLG+ A A+ C++L + A +A Q F +V EE L++ + + +S+D
Sbjct: 154 ESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSD 213
Query: 488 SLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSE 547
L +EE V+E VI W+ D R ++ A L+ VRLP + YL+ V+ E L+K+S
Sbjct: 214 KLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSS 273
Query: 548 ACRDLVNEAKRYHMLP-HARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVT 606
AC+D + EA +YH+LP R M++ RTR R + +++V+VGG+ +++ +V
Sbjct: 274 ACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQ-----APKAIRSVE 328
Query: 607 CWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLV 666
C++ + +W+ +A LP V AG ++ GG + + V Y + D W V
Sbjct: 329 CYDFKEERWHQVAELPSRRCRAGMVYMAG-LVFAVGGFNGSLRVRTVDSYDPVKDQWTSV 387
Query: 667 SRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAAT 726
+ M R + V +G +Y +GG + + VE Y+ +N+W VAP+ S
Sbjct: 388 ANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVG 447
Query: 727 VCGGKIYVFGGVNEAGR-AAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG 785
V GG +Y GG + A R ++ Y TN W++I A LN ++ +GG
Sbjct: 448 VVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG 507
Query: 786 ----AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNME 841
++ +YDP + +MN R+ ++G +Y GG S L ++E
Sbjct: 508 HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN--LASVE 565
Query: 842 AYEPTTNTWTLL 853
Y PTT+ WT++
Sbjct: 566 YYNPTTDKWTVV 577
Score = 72.0 bits (175), Expect = 2e-12
Identities = 80/344 (23%), Positives = 128/344 (37%), Gaps = 29/344 (8%)
Query: 528 IHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHARQEM-QTPRTRPRLSAGVAEVI 586
+HP L + AC DL+N+A Y A Q + L+ G+ +V
Sbjct: 157 LHPVNCLGI----RAFADMHACTDLLNKANTY-----AEQHFADVVLSEEFLNLGIEQVC 207
Query: 587 VLVGGRQM-VGMTQRSLVAVTCWNPQNN--------KWYPLASLPFYDREFFSVVSAGDN 637
L+ ++ + ++ AV W + + LP RE+ V +
Sbjct: 208 SLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYL-VQRVEEE 266
Query: 638 IYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNV 697
+ L + Y L ++ + R R + + K+ + G +
Sbjct: 267 ALVKNSSACKDYLIEAMKYHLLPTEQRILMKSV--RTRLRTPMNLPKLMVVVGGQAPKAI 324
Query: 698 DHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNT 757
VE YD +W VA LP A G ++ GG N + R V SY P +
Sbjct: 325 RSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTV-DSYDPVKDQ 383
Query: 758 WSFIESPMIDNKYAPAVTLNGFVFILGGAYARATTIYDPEKGNIKAGP-----NMNHSRQ 812
W+ + + A LNG ++ +GG + +T + E NIK+ MN R
Sbjct: 384 WTSVANMRDRRSTLGAAVLNGLLYAVGG-FDGSTGLSSVEAYNIKSNEWFHVAPMNTRRS 442
Query: 813 FCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHM 856
V+ G +YA GG + L +E Y TTN WT + M
Sbjct: 443 SVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM 486
Score = 50.1 bits (118), Expect = 9e-06
Identities = 42/148 (28%), Positives = 67/148 (45%), Gaps = 10/148 (6%)
Query: 572 PRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREF 628
P R S GV V + VGG G +++ L V C+N N+W +A + R
Sbjct: 436 PMNTRRSSVGVGVVGGLLYAVGGYD--GASRQCLSTVECYNATTNEWTYIAEMSTR-RSG 492
Query: 629 FSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV--YDGKIY 686
V + +Y GG + + V Y + W V+ M + CR N+ V +G +Y
Sbjct: 493 AGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNM--CRRNAGVCAVNGLLY 550
Query: 687 TLGGLGVAGNVDHVERYDTITNQWEAVA 714
+GG + N+ VE Y+ T++W V+
Sbjct: 551 VVGGDDGSCNLASVEYYNPTTDKWTVVS 578
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 275 bits (703), Expect = 1e-73
Identities = 168/552 (30%), Positives = 274/552 (49%), Gaps = 19/552 (3%)
Query: 308 DPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQ 367
+P H ++ K +N+ R D+ IV E E H+ VLA+CS YF + + +S
Sbjct: 35 NPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSES-- 92
Query: 368 GGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
R K + + + L +L+++VYT + + N + LL AA Q K C FL
Sbjct: 93 --RAK-RVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFL 149
Query: 428 EKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSND 487
E QL NCLG+ A A+ C++L + A +A Q F +V EE L++ + + +S+D
Sbjct: 150 ESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSD 209
Query: 488 SLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSE 547
L +EE V+E VI W+ D R ++ A L+ VRLP + YL+ V+ E L+K+S
Sbjct: 210 KLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSS 269
Query: 548 ACRDLVNEAKRYHMLP-HARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVT 606
AC+D + EA +YH+LP R M++ RTR R + +++V+VGG+ +++ +V
Sbjct: 270 ACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQ-----APKAIRSVE 324
Query: 607 CWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLV 666
C++ + +W+ +A LP V AG ++ GG + + V Y + D W V
Sbjct: 325 CYDFKEERWHQVAELPSRRCRAGMVYMAG-LVFAVGGFNGSLRVRTVDSYDPVKDQWTSV 383
Query: 667 SRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAAT 726
+ M R + V +G +Y +GG + + VE Y+ +N+W VAP+ S
Sbjct: 384 ANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVG 443
Query: 727 VCGGKIYVFGGVNEAGR-AAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG 785
V GG +Y GG + A R ++ Y TN W++I A LN ++ +GG
Sbjct: 444 VVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG 503
Query: 786 ----AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNME 841
++ +YDP + +MN R+ ++G +Y GG S L ++E
Sbjct: 504 HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN--LASVE 561
Query: 842 AYEPTTNTWTLL 853
Y PTT+ WT++
Sbjct: 562 YYNPTTDKWTVV 573
Score = 72.0 bits (175), Expect = 2e-12
Identities = 80/344 (23%), Positives = 128/344 (37%), Gaps = 29/344 (8%)
Query: 528 IHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHARQEM-QTPRTRPRLSAGVAEVI 586
+HP L + AC DL+N+A Y A Q + L+ G+ +V
Sbjct: 153 LHPVNCLGI----RAFADMHACTDLLNKANTY-----AEQHFADVVLSEEFLNLGIEQVC 203
Query: 587 VLVGGRQM-VGMTQRSLVAVTCWNPQNN--------KWYPLASLPFYDREFFSVVSAGDN 637
L+ ++ + ++ AV W + + LP RE+ V +
Sbjct: 204 SLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYL-VQRVEEE 262
Query: 638 IYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNV 697
+ L + Y L ++ + R R + + K+ + G +
Sbjct: 263 ALVKNSSACKDYLIEAMKYHLLPTEQRILMKSV--RTRLRTPMNLPKLMVVVGGQAPKAI 320
Query: 698 DHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNT 757
VE YD +W VA LP A G ++ GG N + R V SY P +
Sbjct: 321 RSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTV-DSYDPVKDQ 379
Query: 758 WSFIESPMIDNKYAPAVTLNGFVFILGGAYARATTIYDPEKGNIKAGP-----NMNHSRQ 812
W+ + + A LNG ++ +GG + +T + E NIK+ MN R
Sbjct: 380 WTSVANMRDRRSTLGAAVLNGLLYAVGG-FDGSTGLSSVEAYNIKSNEWFHVAPMNTRRS 438
Query: 813 FCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHM 856
V+ G +YA GG + L +E Y TTN WT + M
Sbjct: 439 SVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM 482
Score = 50.1 bits (118), Expect = 9e-06
Identities = 42/148 (28%), Positives = 67/148 (45%), Gaps = 10/148 (6%)
Query: 572 PRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREF 628
P R S GV V + VGG G +++ L V C+N N+W +A + R
Sbjct: 432 PMNTRRSSVGVGVVGGLLYAVGGYD--GASRQCLSTVECYNATTNEWTYIAEMSTR-RSG 488
Query: 629 FSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV--YDGKIY 686
V + +Y GG + + V Y + W V+ M + CR N+ V +G +Y
Sbjct: 489 AGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNM--CRRNAGVCAVNGLLY 546
Query: 687 TLGGLGVAGNVDHVERYDTITNQWEAVA 714
+GG + N+ VE Y+ T++W V+
Sbjct: 547 VVGGDDGSCNLASVEYYNPTTDKWTVVS 574
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 274 bits (701), Expect = 2e-73
Identities = 173/553 (31%), Positives = 268/553 (48%), Gaps = 21/553 (3%)
Query: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
H + +L +N R++ D+ + VE ++F H+ VLA+CS YF + + + G
Sbjct: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKG---- 70
Query: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
K + + L A +E+LL+FVYT ++ + N + LL AA Q + C FLE Q
Sbjct: 71 -KPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQ 129
Query: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
L SNCLG+ AE C +L A+ F+ + FPEV EE + +S+ + + D +
Sbjct: 130 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQ 189
Query: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
+EE V+E VI W+K R + LL VR+P + P Y+ +V+D E I+ S CR
Sbjct: 190 VDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCR 249
Query: 551 DLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNP 610
DLV+EAK++H+ P R +MQ PRTR RL G EV+++VGG G Q + V ++P
Sbjct: 250 DLVDEAKKFHLRPELRSQMQGPRTRARL--GANEVLLVVGG---FGSQQSPIDVVEKYDP 304
Query: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDN---WNLVS 667
+ +W L S+ R + + VS D IY+ GG + L+ V C D W V+
Sbjct: 305 KTQEWSFLPSIT-RKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVA 363
Query: 668 RMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATV 727
M V R + IY GG + +ERYD +QW + + A A V
Sbjct: 364 PMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVV 423
Query: 728 CGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG-- 785
G IY GG + V + Y P T W+ + A LN ++++GG
Sbjct: 424 ASGVIYCLGGYDGLNILNSV-EKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFD 482
Query: 786 --AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAY 843
A+ + Y+ + +M R + A VL G++YA G + L ++E Y
Sbjct: 483 GTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNS--LLSSIECY 540
Query: 844 EPTTNTWTLLPHM 856
+P ++W ++ M
Sbjct: 541 DPIIDSWEVVTSM 553
Score = 64.3 bits (155), Expect = 5e-10
Identities = 57/215 (26%), Positives = 90/215 (41%), Gaps = 10/215 (4%)
Query: 665 LVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGN-VDHVERYDTITNQWEAVAPLPKAVHSA 723
L S+M PR R L + + +GG G + +D VE+YD T +W + + +
Sbjct: 264 LRSQMQGPRTRAR-LGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYV 322
Query: 724 AATVCGGKIYVFGGVNEAGRAAGV--LQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVF 781
A+ +IYV GG + R + V L + W + + A A TL ++
Sbjct: 323 ASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIY 382
Query: 782 ILGG--AYARATTI--YDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPAL 837
+ GG R T++ YDP +M +R+ VV G IY GG L
Sbjct: 383 VSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLN--IL 440
Query: 838 GNMEAYEPTTNTWTLLPHMPCPVFRHGCVVIKKYI 872
++E Y+P T WT + M G ++ +I
Sbjct: 441 NSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHI 475
Score = 41.2 bits (95), Expect = 0.004
Identities = 32/128 (25%), Positives = 55/128 (42%), Gaps = 11/128 (8%)
Query: 551 DLVNEAKRYHMLPHARQEMQ-TPRTRPRLSAGVA---EVIVLVGGRQMVGMTQRSLVAVT 606
+++N ++Y PH TP R AGVA + I +VGG L +V
Sbjct: 438 NILNSVEKYD--PHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA----HLSSVE 491
Query: 607 CWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLV 666
+N + + W + S+ R + +Y G + L+ + CY ++D+W +V
Sbjct: 492 AYNIRTDSWTTVTSMTT-PRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVV 550
Query: 667 SRMTVPRC 674
+ M RC
Sbjct: 551 TSMGTQRC 558
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 272 bits (696), Expect = 9e-73
Identities = 173/602 (28%), Positives = 286/602 (47%), Gaps = 29/602 (4%)
Query: 278 APATNGPPTTDSAHGLQMLRTIGVGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEG 337
AP+T+ P ++ + K +F D G + L R A TD+ + V+
Sbjct: 25 APSTDEPSQKTG----DLVEILNGEKVKFDDAGLSLILQNGLETLRMENALTDVILCVDI 80
Query: 338 REFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSL 397
+EF H+ VLA+ S YF+ + +++ + + +++ + A+ + LL++ YT
Sbjct: 81 QEFSCHRVVLAAASNYFRAMFCNDLKE-----KYEKRIIIKGVDAETMHTLLDYTYTSKA 135
Query: 398 VIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKA 457
+I N + +LEAA+ FQF C SFL + L NC+G+L +A+ L ++
Sbjct: 136 LITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQS 195
Query: 458 FALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAA 517
+ +Q F ++ EE L + D + +D L E V+ETV+ W++ P+ R
Sbjct: 196 YIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLP 255
Query: 518 ELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPR 577
+L VRLP + P Y + V+ + LI+ L+ EA+ YH+ + E+ + RT+PR
Sbjct: 256 YVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHL---SGNEIISERTKPR 312
Query: 578 LSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREF--------- 628
+ +EV +++GG +R + VTC +P +A LP + E
Sbjct: 313 MHEFQSEVFMIIGG---CTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVE 369
Query: 629 FSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTL 688
F+ V+ + +Y+SGG E T DVW Y S ++ W + + + R RH +V GK+Y +
Sbjct: 370 FACVTLKNEVYISGGKE---TQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVI 426
Query: 689 GGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVL 748
GG +++VE YD N W APL V S AAT K+YV GG A
Sbjct: 427 GGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKT 486
Query: 749 QSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYARATTIYDPEKGNIKAGPNMN 808
Q Y P TN WS + ++ K AV+ ++++GGA RA Y P + + ++
Sbjct: 487 QCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGA-MRALYAYSPLEDSWCLVTQLS 545
Query: 809 HSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVI 868
H R C + ++Y TGG + + + ++P T +P V HG V I
Sbjct: 546 HERASCGIAPCNNRLYITGG-RDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTI 604
Query: 869 KK 870
+K
Sbjct: 605 RK 606
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 267 bits (683), Expect = 3e-71
Identities = 174/564 (30%), Positives = 268/564 (47%), Gaps = 18/564 (3%)
Query: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
HPR+ L+ +N R+ + D+ +VV ++ H+ +L++CS YF+ + + +S Q
Sbjct: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQ--- 106
Query: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
E+V+ ++ +ELL++F YT + ++ N +TLL AA Q + C FL++Q
Sbjct: 107 --TEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQ 164
Query: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
L SNCLG+ A A+ C EL +A F F EV EE + + + I +S+D LN
Sbjct: 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELN 224
Query: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
++EE V+ V+ W+K R ++L VRLP + P +L+ V ++ LIKS E CR
Sbjct: 225 VRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECR 284
Query: 551 DLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNP 610
DLV+EAK Y +LP R MQ PRTRPR EV+ VGG + ++ +V ++P
Sbjct: 285 DLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGG----WCSGDAISSVERYDP 340
Query: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNL-VSRM 669
Q N+W +AS+ R V D +Y GG + L V Y + W+ V+
Sbjct: 341 QTNEWRMVASMS-KRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPT 399
Query: 670 TVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCG 729
+ R V G +Y +GG ++ VERYD N+W VA + A V G
Sbjct: 400 STCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLG 459
Query: 730 GKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG---- 785
G +Y GG ++ ++ Y PQ N W I K+ ++ +GG
Sbjct: 460 GFLYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDT 518
Query: 786 AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEP 845
+ Y+P M R V++G++ A GG + L +E ++P
Sbjct: 519 TELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGT--TYLKTIEVFDP 576
Query: 846 TTNTWTLLPHMPCPVFRHGCVVIK 869
NTW L M G VIK
Sbjct: 577 DANTWRLYGGMNYRRLGGGVGVIK 600
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 265 bits (678), Expect = 1e-70
Identities = 169/544 (31%), Positives = 253/544 (46%), Gaps = 16/544 (2%)
Query: 319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLS 378
+ + RR D+ + + +F H+ VLA+ YF + + + Q E+V+
Sbjct: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQD-----EIVMQ 82
Query: 379 NLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
+ LE L+ F Y G+L ID N ++LL AS Q + C +FL ++L NCLG
Sbjct: 83 GMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLG 142
Query: 439 VLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVY 498
V AE M C+ LY A +F Q F EV+ EE L++ +D + VS D LN K+EE V+
Sbjct: 143 VRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVF 202
Query: 499 ETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKR 558
E + W++ D R Y ELL+ +RLP P +L + V ++L++ CRDLV+EAK
Sbjct: 203 EAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKD 262
Query: 559 YHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPL 618
YH++P R + RTRPR +A +I VGG G SL V ++P N W
Sbjct: 263 YHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAG---DSLNVVEVFDPIANCWERC 319
Query: 619 ASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNS 678
+ R V +Y GG + + L+ V Y D W V M R +
Sbjct: 320 RPMT-TARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGT 378
Query: 679 LVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGV 738
+V DG+IY GG ++ VE Y T++W V + +A TV G+IYV GG
Sbjct: 379 VVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGG- 437
Query: 739 NEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG----AYARATTIY 794
++ + ++ Y T TW + A +L +F+ GG + +Y
Sbjct: 438 HDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMY 497
Query: 795 DPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLP 854
M+ R S V G++YA GG L ++E Y+P T+ WT +
Sbjct: 498 SSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSN--LSSVEMYDPETDCWTFMA 555
Query: 855 HMPC 858
M C
Sbjct: 556 PMAC 559
Score = 37.0 bits (84), Expect = 0.080
Identities = 26/99 (26%), Positives = 44/99 (44%), Gaps = 7/99 (7%)
Query: 775 TLNGFVFILGGAYARATT-----IYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGI 829
++ G ++ +GG + + ++DP + M +R V++G +YA GG
Sbjct: 285 SIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGY 344
Query: 830 VSSEGPALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVI 868
L +EAY P T+TWT + M G VV+
Sbjct: 345 DGQL--RLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVL 381
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 249 bits (635), Expect = 1e-65
Identities = 168/606 (27%), Positives = 281/606 (46%), Gaps = 33/606 (5%)
Query: 276 SGAPATNGPPTTDSAHGLQMLRTIGVGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVV 335
S +N T S H ++ + F H + K++ R K D+ +V
Sbjct: 125 SSCRTSNSSQTLSSCHTMEPCTSDEF----FQALNHAEQTFKKMENYLRHKQLCDVILVA 180
Query: 336 EGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTG 395
R H+ VL+S S YF + V+++ Q E+ + ++ + L L+++ YTG
Sbjct: 181 GDRRIPAHRLVLSSVSDYFAAMFTNDVREARQE-----EIKMEGVEPNSLWSLIQYAYTG 235
Query: 396 SLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMA 455
L + N + LL A Q + C FL KQL SNCLG+ + A+A C++L+ +A
Sbjct: 236 RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVA 295
Query: 456 KAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQY 515
+ ++ F EV +E + + + +++D +N EE + ++ W++ D R +
Sbjct: 296 HNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKD 355
Query: 516 AAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTR 575
++LLA +RLP + P +L + ++N L + C+ L+ EA +YH+LP R +Q+PRT+
Sbjct: 356 LSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTK 414
Query: 576 PRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAG 635
PR S + VGG + + ++ ++ + N W P+A++ R F V
Sbjct: 415 PRKS--TVGTLFAVGGMD----STKGATSIEKYDLRTNMWTPVANMN-GRRLQFGVAVLD 467
Query: 636 DNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAG 695
D +Y+ GG + TL V CY W+++ M+ R V +G +Y +GG
Sbjct: 468 DKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS 527
Query: 696 NVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQT 755
++ VER+D QW VA + + V GK+Y GG + ++ + P T
Sbjct: 528 YLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG-RDGSSCLKSVECFDPHT 586
Query: 756 NTWSFIESPMIDNKYAPAVTLNGFVFILGGAYARATTI----------YDPEKGNIKAGP 805
N W+ T NG ++ +GG A A+ + YDP+ A
Sbjct: 587 NKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVA 646
Query: 806 NMNHSRQFCSAVVLDGKIYATGGIVSSEGPA-LGNMEAYEPTTNTWTLLPHMPCPVFRHG 864
+M+ SR +L K+YA GG +G A L +EAY+P TN WT + + C
Sbjct: 647 SMSISRDAVGVCLLGDKLYAVGGY---DGQAYLNTVEAYDPQTNEWTQVAPL-CLGRAGA 702
Query: 865 CVVIKK 870
CVV K
Sbjct: 703 CVVTVK 708
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 249 bits (635), Expect = 1e-65
Identities = 168/606 (27%), Positives = 281/606 (46%), Gaps = 33/606 (5%)
Query: 276 SGAPATNGPPTTDSAHGLQMLRTIGVGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVV 335
S +N T S H ++ + F H + K++ R K D+ +V
Sbjct: 171 SSCRTSNSSQTLSSCHTMEPCTSDEF----FQALNHAEQTFKKMENYLRHKQLCDVILVA 226
Query: 336 EGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTG 395
R H+ VL+S S YF + V+++ Q E+ + ++ + L L+++ YTG
Sbjct: 227 GDRRIPAHRLVLSSVSDYFAAMFTNDVREARQE-----EIKMEGVEPNSLWSLIQYAYTG 281
Query: 396 SLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMA 455
L + N + LL A Q + C FL KQL SNCLG+ + A+A C++L+ +A
Sbjct: 282 RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVA 341
Query: 456 KAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQY 515
+ ++ F EV +E + + + +++D +N EE + ++ W++ D R +
Sbjct: 342 HNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKD 401
Query: 516 AAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTR 575
++LLA +RLP + P +L + ++N L + C+ L+ EA +YH+LP R +Q+PRT+
Sbjct: 402 LSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTK 460
Query: 576 PRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAG 635
PR S + VGG + + ++ ++ + N W P+A++ R F V
Sbjct: 461 PRKS--TVGTLFAVGGMD----STKGATSIEKYDLRTNMWTPVANMN-GRRLQFGVAVLD 513
Query: 636 DNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAG 695
D +Y+ GG + TL V CY W+++ M+ R V +G +Y +GG
Sbjct: 514 DKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS 573
Query: 696 NVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQT 755
++ VER+D QW VA + + V GK+Y GG + ++ + P T
Sbjct: 574 YLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG-RDGSSCLKSVECFDPHT 632
Query: 756 NTWSFIESPMIDNKYAPAVTLNGFVFILGGAYARATTI----------YDPEKGNIKAGP 805
N W+ T NG ++ +GG A A+ + YDP+ A
Sbjct: 633 NKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVA 692
Query: 806 NMNHSRQFCSAVVLDGKIYATGGIVSSEGPA-LGNMEAYEPTTNTWTLLPHMPCPVFRHG 864
+M+ SR +L K+YA GG +G A L +EAY+P TN WT + + C
Sbjct: 693 SMSISRDAVGVCLLGDKLYAVGGY---DGQAYLNTVEAYDPQTNEWTQVAPL-CLGRAGA 748
Query: 865 CVVIKK 870
CVV K
Sbjct: 749 CVVTVK 754
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 248 bits (634), Expect = 1e-65
Identities = 171/567 (30%), Positives = 273/567 (48%), Gaps = 32/567 (5%)
Query: 306 FTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDS 365
F HP +L LN R+ FTD+ + R F H+ VLA+ S YF+ + +++S
Sbjct: 23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRES 82
Query: 366 GQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVS 425
R+ NL +VLELLL+F Y+ + I+ NA++LLEA QFH
Sbjct: 83 ----RDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAE 138
Query: 426 FLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVS 485
FLEK L SNCLG++ +++A QC LY + L F V E+ S+SKD + +S
Sbjct: 139 FLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLIS 198
Query: 486 NDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKS 545
+D L T+ E +V+E +++W+K D R + ELL VRL + L V +E L+ +
Sbjct: 199 SDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMA 258
Query: 546 SEACRDLVNEAKRYHMLPHARQEMQT-PRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVA 604
E + +++EA R + T P RPR + ++++GG+ +
Sbjct: 259 DERTKLIMDEALRCKTRILQNDGVVTSPCARPRKA---GHTLLILGGQTFM------CDK 309
Query: 605 VTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSG--GMESGVTLADVWCYMSLLDN 662
+ + + + P A LP R+ FS + G +Y++G G E+GV+ DVW Y ++ +
Sbjct: 310 IYQVDHKAKEIIPKADLP-SPRKEFSASAIGCKVYVTGGRGSENGVS-KDVWVYDTVHEE 367
Query: 663 WNLVSRMTVPRCRHNSLVYDGKIYTLGG-LGVAG--------NVDHVERYDTITNQWEAV 713
W+ + M + R H S + +Y +GG +AG ++ VE+YD N+W V
Sbjct: 368 WSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMV 427
Query: 714 APLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPA 773
APL V +AA K++VFGG + +Q Y P N W+ +Y A
Sbjct: 428 APLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAA 487
Query: 774 VTLNGFVFILGG---AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIV 830
L +FI+GG A + +D E +M R C A+ K+Y GG
Sbjct: 488 AVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYF 547
Query: 831 SSEGPALGNMEAYEPTTNTWTLLPHMP 857
++ ++ Y+PT++TW + +P
Sbjct: 548 GTQ--RCKTLDCYDPTSDTWNCITTVP 572
Score = 36.6 bits (83), Expect = 0.10
Identities = 41/189 (21%), Positives = 64/189 (33%), Gaps = 37/189 (19%)
Query: 672 PRCRHNSLVYDGKIYTLGGLGVAGNVDH-VERYDTITNQWEAVAPLPKAVHSAAATVCGG 730
PR ++ K+Y GG G V V YDT+ +W AP+ A +
Sbjct: 329 PRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELEN 388
Query: 731 KIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYARA 790
+YV GG AGV + +P+V+L +
Sbjct: 389 CLYVVGGHTSL---AGVFPA--------------------SPSVSL------------KQ 413
Query: 791 TTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTW 850
YDP + + V K++ GG S + ++ Y+P+ N W
Sbjct: 414 VEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGG-TSIHRDMVSKVQCYDPSENRW 472
Query: 851 TLLPHMPCP 859
T+ P P
Sbjct: 473 TIKAECPQP 481
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 247 bits (631), Expect = 3e-65
Identities = 147/475 (30%), Positives = 239/475 (50%), Gaps = 14/475 (2%)
Query: 385 LELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAE 444
L +L+++VYT + + N + LL AA Q K C FLE QL NCLG+ A A+
Sbjct: 19 LRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFAD 78
Query: 445 AMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKW 504
C++L + A +A Q F +V EE L++ + + +S+D L +EE V+E VI W
Sbjct: 79 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAW 138
Query: 505 IKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLP- 563
+ D R ++ A L+ VRLP + YL+ V+ E L+K+S AC+D + EA +YH+LP
Sbjct: 139 VNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPT 198
Query: 564 HARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPF 623
R M++ RTR R + +++V+VGG+ +++ +V C++ + +W+ +A LP
Sbjct: 199 EQRILMKSVRTRLRTPMNLPKLMVVVGGQ-----APKAIRSVECYDFKEERWHQVAELPS 253
Query: 624 YDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDG 683
V AG ++ GG + + V Y + D W V+ M R + V +G
Sbjct: 254 RRCRAGMVYMAG-LVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNG 312
Query: 684 KIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGR 743
+Y +GG + + VE Y+ +N+W VAP+ S V GG +Y GG + A R
Sbjct: 313 LLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASR 372
Query: 744 -AAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG----AYARATTIYDPEK 798
++ Y TN W++I A LN ++ +GG ++ +YDP
Sbjct: 373 QCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTT 432
Query: 799 GNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLL 853
+ +MN R+ ++G +Y GG S L ++E Y PTT+ WT++
Sbjct: 433 NAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN--LASVEYYNPTTDKWTVV 485
Score = 72.0 bits (175), Expect = 2e-12
Identities = 80/344 (23%), Positives = 128/344 (37%), Gaps = 29/344 (8%)
Query: 528 IHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHARQEM-QTPRTRPRLSAGVAEVI 586
+HP L + AC DL+N+A Y A Q + L+ G+ +V
Sbjct: 65 LHPVNCLGI----RAFADMHACTDLLNKANTY-----AEQHFADVVLSEEFLNLGIEQVC 115
Query: 587 VLVGGRQM-VGMTQRSLVAVTCWNPQNN--------KWYPLASLPFYDREFFSVVSAGDN 637
L+ ++ + ++ AV W + + LP RE+ V +
Sbjct: 116 SLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYL-VQRVEEE 174
Query: 638 IYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNV 697
+ L + Y L ++ + R R + + K+ + G +
Sbjct: 175 ALVKNSSACKDYLIEAMKYHLLPTEQRILMKSV--RTRLRTPMNLPKLMVVVGGQAPKAI 232
Query: 698 DHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNT 757
VE YD +W VA LP A G ++ GG N + R V SY P +
Sbjct: 233 RSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTV-DSYDPVKDQ 291
Query: 758 WSFIESPMIDNKYAPAVTLNGFVFILGGAYARATTIYDPEKGNIKAGP-----NMNHSRQ 812
W+ + + A LNG ++ +GG + +T + E NIK+ MN R
Sbjct: 292 WTSVANMRDRRSTLGAAVLNGLLYAVGG-FDGSTGLSSVEAYNIKSNEWFHVAPMNTRRS 350
Query: 813 FCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHM 856
V+ G +YA GG + L +E Y TTN WT + M
Sbjct: 351 SVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM 394
Score = 50.1 bits (118), Expect = 9e-06
Identities = 42/148 (28%), Positives = 67/148 (45%), Gaps = 10/148 (6%)
Query: 572 PRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREF 628
P R S GV V + VGG G +++ L V C+N N+W +A + R
Sbjct: 344 PMNTRRSSVGVGVVGGLLYAVGGYD--GASRQCLSTVECYNATTNEWTYIAEMSTR-RSG 400
Query: 629 FSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV--YDGKIY 686
V + +Y GG + + V Y + W V+ M + CR N+ V +G +Y
Sbjct: 401 AGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNM--CRRNAGVCAVNGLLY 458
Query: 687 TLGGLGVAGNVDHVERYDTITNQWEAVA 714
+GG + N+ VE Y+ T++W V+
Sbjct: 459 VVGGDDGSCNLASVEYYNPTTDKWTVVS 486
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 247 bits (630), Expect = 4e-65
Identities = 166/555 (29%), Positives = 260/555 (46%), Gaps = 33/555 (5%)
Query: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
H ++L+ LN R+ D+ + V + H+ VLAS S YFK + ++ + +
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSE-----K 71
Query: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
E E+ + L+ ++E+ YTG++ I ++LL AA+ Q K C +FLE Q
Sbjct: 72 ENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQ 131
Query: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
L NC+G+ AE C +LY A + Q F V EE ++ D VSND LN
Sbjct: 132 LDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLN 191
Query: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
EE V+ + WIK D R +Y A+LL VRLP + +L + + LI+ C+
Sbjct: 192 VATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCK 251
Query: 551 DLVNEAKRYHMLPHARQEMQTP-RTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWN 609
L+NEA +YH +P R QT TRPR + +V+ VGG+ + L +V +
Sbjct: 252 HLLNEALKYHFMPEHRLSHQTVLMTRPRCA---PKVLCAVGGKSGL---FACLDSVEMYF 305
Query: 610 PQNNKWYPLA--SLPFYDREFFSVVSAGDNIYLSGGMES----GVTLA----DVWCYMSL 659
PQN+ W LA ++P Y+ F + +Y+ GG+ + GVT+ V C+
Sbjct: 306 PQNDSWIGLAPLNIPRYE---FGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPD 362
Query: 660 LDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKA 719
+ W + RM R +V G++Y LGG + VE+Y +W+ VAP+
Sbjct: 363 TNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTT 422
Query: 720 VHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGF 779
AA V G IY GG A + ++ Y P ++W + S + + GF
Sbjct: 423 RSCFAAAVLDGMIYAIGGYGPAHMNS--VERYDPSKDSWEMVASMADKRIHFGVGVMLGF 480
Query: 780 VFILGG----AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGP 835
+F++GG ++ + YDP + M R A V+D +Y GG S
Sbjct: 481 IFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGG--HSGSS 538
Query: 836 ALGNMEAYEPTTNTW 850
L ++ Y+P ++TW
Sbjct: 539 YLNTVQKYDPISDTW 553
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 245 bits (626), Expect = 1e-64
Identities = 175/570 (30%), Positives = 258/570 (45%), Gaps = 30/570 (5%)
Query: 304 YEFTDPGHPREMLKELNQQRRAKAFTDLKIVV-EGREFEVHQNVLASCSLYFKDLIQRSV 362
Y F D HP + L FTD+ + G F H+ VLA+CS YFK + +
Sbjct: 11 YLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADM 70
Query: 363 QDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKV 422
++ + K ++ LS + D+LE L+ + YT + I N ++LLEAA QF + K
Sbjct: 71 KE-----KFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKA 125
Query: 423 CVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIA 482
C FL + L NC+G+ + AE C EL ++ F EV QEE L IS + F+
Sbjct: 126 CERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLF 185
Query: 483 YVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEEL 542
+S +L+ EE + E VIKW D R + LL+ + + I P YL +
Sbjct: 186 ILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINID-IDPVYL------KTA 238
Query: 543 IKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSL 602
+ +C L+ E K ++ +A M +S + ++GG L
Sbjct: 239 LGLQRSC--LLTENKIRSLIYNALNPM-----HKEISQRSTATMYIIGGYYW-----HPL 286
Query: 603 VAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESG--VTLADVWCYMSLL 660
V W+P N W A +P Y RE + V G NIY++GG + L VW Y S
Sbjct: 287 SEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSES 346
Query: 661 DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAV 720
D W M R H ++ G +Y LGG + E YD + +W +A + K V
Sbjct: 347 DEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGV 406
Query: 721 HSAAATVCGGKIYVFGG--VNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNG 778
+A A V IYV GG +QSY N WS I S +V
Sbjct: 407 GNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFEN 466
Query: 779 FVFILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALG 838
++++GG T YDPE+ + M R C AV+++G IY TGG S+G L
Sbjct: 467 KLYLVGG-QTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQ 525
Query: 839 NMEAYEPTTNTWTLLPHMPCPVFRHGCVVI 868
++E Y+P N W ++ ++P + HGCV +
Sbjct: 526 SIEKYDPDLNKWEIVGNLPSAMRSHGCVCV 555
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 239 bits (609), Expect = 1e-62
Identities = 176/593 (29%), Positives = 280/593 (47%), Gaps = 46/593 (7%)
Query: 304 YEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQ 363
Y F + +L LN R+ + FTD+ + R F H+ VLA+CS YF+ + ++
Sbjct: 21 YLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLK 80
Query: 364 DSGQGGREKLELVLSN-LQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKV 422
+S + E+ N + +VLELLL++ Y+ ++I+ NA++LLEA +F
Sbjct: 81 ES-----QDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDA 135
Query: 423 CVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIA 482
C FLEK L +NCLG+L +++A QC++LY ++ L F + E+ L + +D +
Sbjct: 136 CAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQ 195
Query: 483 YVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEEL 542
+S++ L T+ E LVYE+ I WI D R Y ELL VRL + YL+ V EEL
Sbjct: 196 LLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEEL 255
Query: 543 IKSSEACRDLVNEAKRYHMLPHARQEMQTPR-TRPRLSAGVAEVIVLVGGRQMVGMTQRS 601
I +++V EA R + + T RPR + + L+GG+ + +
Sbjct: 256 ITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKT---GHALFLLGGQTFM-CDKLY 311
Query: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSG--GMESGVTLADVWCYMSL 659
LV + + + P A +P R+ FS + G +Y++G G E+GV+ DVW Y +L
Sbjct: 312 LV-----DQKAKEIIPKADIP-SPRKEFSACAIGCKVYITGGRGSENGVS-KDVWVYDTL 364
Query: 660 LDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAG---------NVDHVERYDTITNQW 710
+ W+ + M V R H S +Y +GG A ++ VE YD N+W
Sbjct: 365 HEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKW 424
Query: 711 EAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKY 770
VAPL + V +AA K++ FGG + + +Q Y N W+ + +Y
Sbjct: 425 TMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRY 484
Query: 771 APAVTLNGFVFILGG--------AYARATTIYDPEK-GNIKAGPNMNHSRQFCSAVVLDG 821
A L +FI+GG AY + Y K G++ A R C AV
Sbjct: 485 TAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTA------KRMSCHAVASGN 538
Query: 822 KIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVIKKYIQS 874
K+Y GG + ++ Y+PT + W + +P + V K++ S
Sbjct: 539 KLYVVGGYFGIQ--RCKTLDCYDPTLDVWNSITTVPYSLIPTAFVSTWKHLPS 589
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 234 bits (598), Expect = 2e-61
Identities = 154/536 (28%), Positives = 257/536 (47%), Gaps = 29/536 (5%)
Query: 346 VLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAK 405
VL+S S YF + V+++ Q E+ + ++ + L L+++ YTG L + N +
Sbjct: 176 VLSSVSDYFAAMFTNDVREARQE-----EIKMEGVEPNSLWSLIQYAYTGRLELKEDNIE 230
Query: 406 TLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPE 465
LL A Q + C FL KQL SNCLG+ + A+A C++L+ +A + ++ F E
Sbjct: 231 CLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFME 290
Query: 466 VAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRL 525
V +E + + + +++D +N EE + ++ W++ D R + ++LLA +RL
Sbjct: 291 VIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRL 350
Query: 526 PFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEV 585
P + P +L + ++N L + C+ L+ EA +YH+LP R +Q+PRT+PR S
Sbjct: 351 PLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKS--TVGT 407
Query: 586 IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGME 645
+ VGG + + ++ ++ + N W P+A++ R F V D +Y+ GG +
Sbjct: 408 LFAVGGMD----STKGATSIEKYDLRTNMWTPVANMN-GRRLQFGVAVLDDKLYVVGGRD 462
Query: 646 SGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDT 705
TL V CY W+++ M+ R V +G +Y +GG ++ VER+D
Sbjct: 463 GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDP 522
Query: 706 ITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPM 765
QW VA + + V GK+Y GG + ++ + P TN W+
Sbjct: 523 QARQWNFVATMSTPRSTVGVAVLSGKLYAVGG-RDGSSCLKSVECFDPHTNKWTLCAQMS 581
Query: 766 IDNKYAPAVTLNGFVFILGGAYARATTI----------YDPEKGNIKAGPNMNHSRQFCS 815
T NG ++ +GG A A+ + YDP+ A +M+ SR
Sbjct: 582 KRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG 641
Query: 816 AVVLDGKIYATGGIVSSEGPA-LGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVIKK 870
+L K+YA GG +G A L +EAY+P TN WT + + C CVV K
Sbjct: 642 VCLLGDKLYAVGGY---DGQAYLNTVEAYDPQTNEWTQVAPL-CLGRAGACVVTVK 693
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 233 bits (595), Expect = 4e-61
Identities = 163/572 (28%), Positives = 267/572 (46%), Gaps = 31/572 (5%)
Query: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
H + +++ + + D+ ++V R+ H+ VL+S S YF + V ++ Q
Sbjct: 194 HAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQE-- 251
Query: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
E+ + + + L L++F YTG L + + LL AA Q +VC FL K
Sbjct: 252 ---EIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKL 308
Query: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
L SNCLG+ A A+A C EL +A ++ ++ EV +E L + ++ +++D +N
Sbjct: 309 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVN 368
Query: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
EE ++ ++ W+K D +R + LLA +RLP + P L + ++N L K+ C+
Sbjct: 369 VPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQ 427
Query: 551 DLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNP 610
L+ EA +YH+LP R MQ+PRT+PR S + VGG + + ++
Sbjct: 428 KLILEAMKYHLLPERRTLMQSPRTKPRKS--TVGTLYAVGGMD----NNKGATTIEKYDL 481
Query: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMT 670
+ N W A + R F V D +++ GG + TL V CY W ++ M+
Sbjct: 482 RTNLWIQ-AGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMS 540
Query: 671 VPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGG 730
R V +G IY +GG ++ VER+D + QW VA + A + G
Sbjct: 541 THRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNG 600
Query: 731 KIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAV-TLNGFVFILGGAYAR 789
K+Y GG + ++ Y P TN W+ +PM + V T +GF++ +GG A
Sbjct: 601 KLYSVGG-RDGSSCLSSMEYYDPHTNKWNMC-APMCKRRGGVGVATCDGFLYAVGGHDAP 658
Query: 790 ATT----------IYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGN 839
A+ YDP+ ++ R +L ++YA GG L
Sbjct: 659 ASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQ--TYLNT 716
Query: 840 MEAYEPTTNTWTLLPHMPCPVFRHG-CVVIKK 870
ME+Y+P TN WT + + + R G CVV+ K
Sbjct: 717 MESYDPQTNEWTQMASL--NIGRAGACVVVIK 746
>gi|128485503 kelch-like 30 [Homo sapiens]
Length = 560
Score = 225 bits (574), Expect = 1e-58
Identities = 166/568 (29%), Positives = 267/568 (47%), Gaps = 39/568 (6%)
Query: 315 MLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLE 374
ML L + R D+ ++V GRE H+ +LA S YF + +S E
Sbjct: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVE--- 57
Query: 375 LVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTAS 434
L +++ V+ L++FVYTG L I N + L A++ F + KVC +L++QL A+
Sbjct: 58 --LRDVEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAA 115
Query: 435 NCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAE 494
NCLG+ E + A AF + F VA ++E L + ++ + ++ D L + E
Sbjct: 116 NCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPE 175
Query: 495 ELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVN 554
+ E +++W++ DP R + ELL++V L + + ++ +E LI+ SEACR ++
Sbjct: 176 QSRLEALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALS 235
Query: 555 EAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMV-----GMTQRSLVAVTCWN 609
+ + P A Q+ + EV+V+VGG+ + L +N
Sbjct: 236 QG--HDGAPLALQQK------------LEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYN 281
Query: 610 PQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVT----LADVWCYMSLLDNWNL 665
+ +W L P Y + FS+ + +NIY++GG T WC+ +W
Sbjct: 282 SKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKP 341
Query: 666 VSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAA 725
V+ M PR H S +G+IY +GG + +V VE YD T+ W V+P K V + +A
Sbjct: 342 VAPMLKPRTNHASAALNGEIYVIGGTTL--DVVEVESYDPYTDSWTPVSPALKYVSNFSA 399
Query: 726 TVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPA---VTLNGFVFI 782
C G++Y+ G + A LQ Y P T+ WS I SP + KY + L+G +++
Sbjct: 400 AGCRGRLYLVGS-SACKYNALALQCYNPVTDAWSVIASPFLP-KYLSSPRCAALHGELYL 457
Query: 783 LGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVV-LDGKIYATGG-IVSSEGPALGNM 840
+G + +YDP N+ HS A+V L +Y TGG EG M
Sbjct: 458 IGD-NTKKVYVYDP-GANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEM 515
Query: 841 EAYEPTTNTWTLLPHMPCPVFRHGCVVI 868
EAY+ +TWT +P HG +
Sbjct: 516 EAYDTVRDTWTRHGALPRLWLYHGASTV 543
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 221 bits (562), Expect = 3e-57
Identities = 152/541 (28%), Positives = 242/541 (44%), Gaps = 26/541 (4%)
Query: 320 NQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSN 379
N+ R D+ I V G EF H+N+L SCS YF+ L SG EK +
Sbjct: 30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFT-----SGWNNTEKKVYNIPG 84
Query: 380 LQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
+ D+++L++E+ YT ++ I N + LL AA +F + C FL+ +L NC+G+
Sbjct: 85 ISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGI 144
Query: 440 LAMAEAMQCSELYHMAKAFALQIFPE-VAAQEEILSISKDDFIAYVSNDSLNTKAEELVY 498
+ C EL A F L F E V E L +S + + D LN K E+ V+
Sbjct: 145 CKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVF 204
Query: 499 ETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKR 558
E ++KWI DP R Q+ + LL VRL +H Y +N V + +K SE C+ ++ A +
Sbjct: 205 EAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALK 264
Query: 559 ----YHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNK 614
+M + + P TRPRL ++ +GG T A+ ++ + ++
Sbjct: 265 AMYDLNMNGPSNSDFTNPLTRPRLPYA---ILFAIGGWSGGSPTN----AIEAYDARADR 317
Query: 615 WYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRC 674
W + R + +Y+ GG +S V + + W+ V+ M RC
Sbjct: 318 WVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRC 377
Query: 675 RHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYV 734
+ V IY +GG ++ ERY+ TNQW +AP+ + A+AT GK+Y+
Sbjct: 378 YVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYI 437
Query: 735 FGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNG-FVFILGG----AYAR 789
GG N + Y ++N W+ I +PM + V G V+ +GG R
Sbjct: 438 CGGFN-GNECLFTAEVYNTESNQWTVI-APMRSRRSGIGVIAYGEHVYAVGGFDGANRLR 495
Query: 790 ATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNT 849
+ Y P + P M + R V+D ++ GG + N+E Y+ T+
Sbjct: 496 SAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGF--NGFTTTFNVECYDEKTDE 553
Query: 850 W 850
W
Sbjct: 554 W 554
Score = 32.3 bits (72), Expect = 2.0
Identities = 20/82 (24%), Positives = 34/82 (41%), Gaps = 1/82 (1%)
Query: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLD 661
L + ++P N W + ++ F R F + D +++ GG T +V CY D
Sbjct: 494 LRSAEAYSPVANTWRTIPTM-FNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTD 552
Query: 662 NWNLVSRMTVPRCRHNSLVYDG 683
W M++ R + V G
Sbjct: 553 EWYDAHDMSIYRSALSCCVVPG 574
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 211 bits (538), Expect = 2e-54
Identities = 144/472 (30%), Positives = 230/472 (48%), Gaps = 22/472 (4%)
Query: 319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLS 378
+N R+ K D+ ++V+ R+ H+ VLA+ S +F + ++ +S + E+ L
Sbjct: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLES-----KSFEVELK 88
Query: 379 NLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
+ + D++E L+EF YT + ++S N ++LL+AA+++Q K+CV FL++Q+ ASNCLG
Sbjct: 89 DAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLG 148
Query: 439 VLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVY 498
+ +AE + C EL A F Q F EV +E L + ++ D+L +AE+ VY
Sbjct: 149 ISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVY 208
Query: 499 ETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKR 558
+ ++W+K D R + ++LA VR P I ++L V E LI+ + C +V R
Sbjct: 209 DAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMR 268
Query: 559 YHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPL 618
YH+L +E TRPR I L GG Q + +NP++ W +
Sbjct: 269 YHLLSPEDREELVDGTRPRRKKHDYR-IALFGGSQP--------QSCRYFNPKDYSWTDI 319
Query: 619 ASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNS 678
PF R + V + +Y+ GG + + + CY + D+W PR +
Sbjct: 320 -RCPFEKRRDAACVFWDNVVYILGGSQL-FPIKRMDCYNVVKDSWYSKLGPPTPRDSLAA 377
Query: 679 LVYDGKIYTLGGLGVAGNVDHV-ERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGG 737
+GKIYT GG V + ++ E YDT T W + S G IYV GG
Sbjct: 378 CAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGG 437
Query: 738 V---NEAGRAAGVLQSYVPQTNTWSFIESPMID-NKYAPAVTLNGFVFILGG 785
N +GR + Y P T TW+ + PMI+ K V + +F +GG
Sbjct: 438 SLGNNVSGRVLNSCEVYDPATETWTEL-CPMIEARKNHGLVFVKDKIFAVGG 488
Score = 45.4 bits (106), Expect = 2e-04
Identities = 39/152 (25%), Positives = 61/152 (40%), Gaps = 8/152 (5%)
Query: 564 HARQEMQTPRTRPRLSAGVAE---VIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLAS 620
H + M T R S G+ E +I + GG ++ R L + ++P W L
Sbjct: 411 HTKPSMLTQRC----SHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP 466
Query: 621 LPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV 680
+ R+ +V D I+ GG L +V Y L+ W +VS M
Sbjct: 467 M-IEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAA 525
Query: 681 YDGKIYTLGGLGVAGNVDHVERYDTITNQWEA 712
+Y L G G + H+ Y+T T++W A
Sbjct: 526 VGSIVYVLAGFQGVGRLGHILEYNTETDKWVA 557
Score = 41.2 bits (95), Expect = 0.004
Identities = 41/142 (28%), Positives = 60/142 (42%), Gaps = 15/142 (10%)
Query: 731 KIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAY--- 787
+I +FGG + + P+ +W+ I P + A V + V+ILGG+
Sbjct: 294 RIALFGGSQPQS-----CRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFP 348
Query: 788 ARATTIYDPEKGN--IKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEG-PALGNMEAYE 844
+ Y+ K + K GP R +A +GKIY +GG S G AL E Y+
Sbjct: 349 IKRMDCYNVVKDSWYSKLGPPT--PRDSLAACAAEGKIYTSGG--SEVGNSALYLFECYD 404
Query: 845 PTTNTWTLLPHMPCPVFRHGCV 866
T +W P M HG V
Sbjct: 405 TRTESWHTKPSMLTQRCSHGMV 426
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 210 bits (535), Expect = 4e-54
Identities = 149/572 (26%), Positives = 258/572 (45%), Gaps = 31/572 (5%)
Query: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
H + L+++ + K D+ ++ H+ VL++ S YF + V ++ Q
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQE-- 221
Query: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
E+ + + + L L+++ YTG L + ++LL AA Q VC +FL KQ
Sbjct: 222 ---EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQ 278
Query: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
L SNCLG+ + +A C+EL ++A + ++ F EV +E L + ++ + +D +N
Sbjct: 279 LHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDIN 338
Query: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
EE ++ +++W+ D R LL+ +RLP + P LL ++ + C+
Sbjct: 339 VPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLL-PPQLLADLETSSMFTGDLECQ 397
Query: 551 DLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNP 610
L+ EA +YH+LP R MQ+PRT+PR S + VGG + + ++
Sbjct: 398 KLLMEAMKYHLLPERRSMMQSPRTKPRKS--TVGALYAVGGMD----AMKGTTTIEKYDL 451
Query: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMT 670
+ N W + ++ R F V + +Y+ GG + TL V C+ + W ++ M+
Sbjct: 452 RTNSWLHIGTMN-GRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMS 510
Query: 671 VPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGG 730
R +G +Y +GG ++ VER+D QW VA + +
Sbjct: 511 THRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNN 570
Query: 731 KIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAV-TLNGFVFILGGAYAR 789
K+Y GG + ++ + P TN WS +PM + V T NGF++++GG A
Sbjct: 571 KLYAIGG-RDGSSCLKSMEYFDPHTNKWSLC-APMSKRRGGVGVATYNGFLYVVGGHDAP 628
Query: 790 ATT----------IYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGN 839
A+ YDP+ + ++ R + L K+Y GG L
Sbjct: 629 ASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY--DGHTYLNT 686
Query: 840 MEAYEPTTNTWTLLPHMPCPVFRHG-CVVIKK 870
+E+Y+ N W +P + R G CVV+ K
Sbjct: 687 VESYDAQRNEWK--EEVPVNIGRAGACVVVVK 716
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 207 bits (527), Expect = 3e-53
Identities = 151/568 (26%), Positives = 255/568 (44%), Gaps = 26/568 (4%)
Query: 306 FTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDS 365
F+ H + +L ++N+ R + F D+++ V F+ H+ VLA+ S YF L +++S
Sbjct: 14 FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKES 73
Query: 366 GQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVS 425
K + + ++A + ++LL+F+YTG + I N + L+ AA Q +C
Sbjct: 74 S-----KDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCE 128
Query: 426 FLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVS 485
FL+ Q+ NC+G+ +E + C +L ++ + F EV + EE L+++KD I +
Sbjct: 129 FLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILR 188
Query: 486 NDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKS 545
++ L+ + E V+ ++WI KD R ++ E+L +R P + P LL ++
Sbjct: 189 SEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNL 248
Query: 546 SEACRDLVNEAKRYHMLPHARQ---EMQTPRTRPRLSA-----GVAEVIVLVGGRQMVGM 597
A + L+ E P + +QT + RPR A V L GGR
Sbjct: 249 RVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGR---WS 305
Query: 598 TQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYM 657
R+L V ++ + W ++SL R V G +Y GG + + CY
Sbjct: 306 DSRALSCVERFDTFSQYWTTVSSL-HQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYD 364
Query: 658 SLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLP 717
+ W V+ M PRC V G IY LGG A + +ER+D N+WE V +
Sbjct: 365 PVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMA 424
Query: 718 KAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLN 777
+ + G IYV GG++ G + Y P + WS + Y LN
Sbjct: 425 VSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALN 484
Query: 778 GFVFILGGAYARATTIYDPEKGNIKAG-----PNMNHSRQFCSAVVLDGKIYATGGIVSS 832
++ +GG ++ EK + + +M R V ++G +Y +GG SS
Sbjct: 485 DCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
Query: 833 EG----PALGNMEAYEPTTNTWTLLPHM 856
L ++E Y P ++TWT + +M
Sbjct: 545 HDFLAPGTLDSVEVYNPHSDTWTEIGNM 572
Score = 50.4 bits (119), Expect = 7e-06
Identities = 39/142 (27%), Positives = 58/142 (40%), Gaps = 8/142 (5%)
Query: 729 GGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYA 788
GG + GG RA ++ + + W+ + S L G V+ +GG
Sbjct: 294 GGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKD 353
Query: 789 R----ATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGN-MEAY 843
T YDP +MNH R V G IYA GG V +E +GN +E +
Sbjct: 354 SMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAE---IGNTIERF 410
Query: 844 EPTTNTWTLLPHMPCPVFRHGC 865
+P N W ++ +M + GC
Sbjct: 411 DPDENKWEVVGNMAVSRYYFGC 432
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 206 bits (525), Expect = 6e-53
Identities = 142/551 (25%), Positives = 248/551 (45%), Gaps = 28/551 (5%)
Query: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
H + L+++ + K D+ ++ H+ VL++ S YF + V ++ Q
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQE-- 221
Query: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
E+ + + + L L+++ YTG L + ++LL AA Q VC +FL KQ
Sbjct: 222 ---EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQ 278
Query: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
L SNCLG+ + +A C+EL ++A + ++ F EV +E L + ++ + +D +N
Sbjct: 279 LHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDIN 338
Query: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
EE ++ +++W+ D R LL+ +RLP + P LL ++ + C+
Sbjct: 339 VPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLL-PPQLLADLETSSMFTGDLECQ 397
Query: 551 DLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNP 610
L+ EA +YH+LP R MQ+PRT+PR S + VGG + + ++
Sbjct: 398 KLLMEAMKYHLLPERRSMMQSPRTKPRKS--TVGALYAVGGMD----AMKGTTTIEKYDL 451
Query: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMT 670
+ N W + ++ R F V + +Y+ GG + TL V C+ + W ++ M+
Sbjct: 452 RTNSWLHIGTMN-GRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMS 510
Query: 671 VPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGG 730
R +G +Y +GG ++ VER+D QW VA + +
Sbjct: 511 THRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNN 570
Query: 731 KIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAV-TLNGFVFILGGAYAR 789
K+Y GG + ++ + P TN WS +PM + V T NGF++++GG A
Sbjct: 571 KLYAIGG-RDGSSCLKSMEYFDPHTNKWSLC-APMSKRRGGVGVATYNGFLYVVGGHDAP 628
Query: 790 ATT----------IYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGN 839
A+ YDP+ + ++ R + L K+Y GG L
Sbjct: 629 ASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY--DGHTYLNT 686
Query: 840 MEAYEPTTNTW 850
+E+Y+ N W
Sbjct: 687 VESYDAQRNEW 697
Score = 77.4 bits (189), Expect = 5e-14
Identities = 98/426 (23%), Positives = 165/426 (38%), Gaps = 50/426 (11%)
Query: 466 VAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETV---------------IKWIKKDPA 510
+ A +LS D F A +ND L K EE+ E V + +K+D
Sbjct: 193 IPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTI 252
Query: 511 TRTQYAAELLAVVR---------LPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRY-- 559
AA LL + + + +HPS L + ++ C +L+N A +Y
Sbjct: 253 ESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGI----RSFGDAQGCTELLNVAHKYTM 308
Query: 560 -HMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPL 618
H + + + +S + + V + + V N Q L
Sbjct: 309 EHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLL 368
Query: 619 A--SLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLV-SRMTVPRCR 675
+ LP + + + +G +E L + Y L + +++ S T PR
Sbjct: 369 SYIRLPLLPPQLLADLETSS--MFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPR-- 424
Query: 676 HNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVF 735
S V G +Y +GG+ +E+YD TN W + + V K+YV
Sbjct: 425 -KSTV--GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVV 481
Query: 736 GGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAV-TLNGFVFILGG----AYARA 790
GG + + ++ + P W+ + PM +++ V TL G ++ +GG +Y
Sbjct: 482 GG-RDGLKTLNTVECFNPVGKIWT-VMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNT 539
Query: 791 TTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTW 850
+DPE +M+ R V L+ K+YA GG S L +ME ++P TN W
Sbjct: 540 VERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS--CLKSMEYFDPHTNKW 597
Query: 851 TLLPHM 856
+L M
Sbjct: 598 SLCAPM 603
Score = 40.8 bits (94), Expect = 0.006
Identities = 38/145 (26%), Positives = 65/145 (44%), Gaps = 14/145 (9%)
Query: 576 PRLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVV 632
PR + GV + + +GGR L ++ ++P NKW A + R V
Sbjct: 559 PRSTVGVVALNNKLYAIGGRD----GSSCLKSMEYFDPHTNKWSLCAPMS-KRRGGVGVA 613
Query: 633 SAGDNIYLSGGMESGVT-----LAD-VWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIY 686
+ +Y+ GG ++ + L+D V Y D+W+ V+ ++VPR K+Y
Sbjct: 614 TYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLY 673
Query: 687 TLGGLGVAGNVDHVERYDTITNQWE 711
+GG ++ VE YD N+W+
Sbjct: 674 VVGGYDGHTYLNTVESYDAQRNEWK 698
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 206 bits (524), Expect = 8e-53
Identities = 142/465 (30%), Positives = 226/465 (48%), Gaps = 22/465 (4%)
Query: 326 KAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVL 385
K D+ ++V+ R+ H+ VLA+ S +F + ++ +S + E+ L + + D++
Sbjct: 19 KTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLES-----KSFEVELKDAEPDII 73
Query: 386 ELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEA 445
E L+EF YT + ++S N ++LL+AA+++Q K+CV FL++Q+ ASNCLG+ +AE
Sbjct: 74 EQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAEC 133
Query: 446 MQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWI 505
+ C EL A F Q F EV +E L + ++ D+L +AE+ VY+ ++W+
Sbjct: 134 LDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWL 193
Query: 506 KKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHA 565
K D R + ++LA VR P I ++L V E LI+ + C +V RYH+L
Sbjct: 194 KYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPE 253
Query: 566 RQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYD 625
+E TRPR I L GG Q + +NP++ W + PF
Sbjct: 254 DREELVDGTRPRRKKHDYR-IALFGGSQP--------QSCRYFNPKDYSWTDI-RCPFEK 303
Query: 626 REFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKI 685
R + V + +Y+ GG + + + CY + D+W PR + +GKI
Sbjct: 304 RRDAACVFWDNVVYILGGSQL-FPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKI 362
Query: 686 YTLGGLGVAGNVDHV-ERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGV---NEA 741
YT GG V + ++ E YDT T W + S G IYV GG N +
Sbjct: 363 YTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVS 422
Query: 742 GRAAGVLQSYVPQTNTWSFIESPMID-NKYAPAVTLNGFVFILGG 785
GR + Y P T TW+ + PMI+ K V + +F +GG
Sbjct: 423 GRVLNSCEVYDPATETWTEL-CPMIEARKNHGLVFVKDKIFAVGG 466
Score = 45.4 bits (106), Expect = 2e-04
Identities = 39/152 (25%), Positives = 61/152 (40%), Gaps = 8/152 (5%)
Query: 564 HARQEMQTPRTRPRLSAGVAE---VIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLAS 620
H + M T R S G+ E +I + GG ++ R L + ++P W L
Sbjct: 389 HTKPSMLTQRC----SHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP 444
Query: 621 LPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV 680
+ R+ +V D I+ GG L +V Y L+ W +VS M
Sbjct: 445 M-IEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAA 503
Query: 681 YDGKIYTLGGLGVAGNVDHVERYDTITNQWEA 712
+Y L G G + H+ Y+T T++W A
Sbjct: 504 VGSIVYVLAGFQGVGRLGHILEYNTETDKWVA 535
Score = 41.2 bits (95), Expect = 0.004
Identities = 41/142 (28%), Positives = 60/142 (42%), Gaps = 15/142 (10%)
Query: 731 KIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAY--- 787
+I +FGG + + P+ +W+ I P + A V + V+ILGG+
Sbjct: 272 RIALFGGSQPQS-----CRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFP 326
Query: 788 ARATTIYDPEKGN--IKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEG-PALGNMEAYE 844
+ Y+ K + K GP R +A +GKIY +GG S G AL E Y+
Sbjct: 327 IKRMDCYNVVKDSWYSKLGPPT--PRDSLAACAAEGKIYTSGG--SEVGNSALYLFECYD 382
Query: 845 PTTNTWTLLPHMPCPVFRHGCV 866
T +W P M HG V
Sbjct: 383 TRTESWHTKPSMLTQRCSHGMV 404
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,582,080
Number of Sequences: 37866
Number of extensions: 2082917
Number of successful extensions: 21024
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 293
Number of HSP's successfully gapped in prelim test: 984
Number of HSP's that attempted gapping in prelim test: 12322
Number of HSP's gapped (non-prelim): 5999
length of query: 875
length of database: 18,247,518
effective HSP length: 111
effective length of query: 764
effective length of database: 14,044,392
effective search space: 10729915488
effective search space used: 10729915488
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.