Search of human proteins with 10835059

Search of human proteins with 10835059

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|10835059 farnesyltransferase, CAAX box, beta [Homo sapiens]
         (437 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|10835059 farnesyltransferase, CAAX box, beta [Homo sapiens]        915   0.0  
gi|21359854 RAB geranylgeranyltransferase, beta subunit [Homo sa...   146   3e-35
gi|167860116 geranylgeranyltransferase type 1 beta [Homo sapiens]     115   6e-26
gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo ...    30   3.3  
gi|150378478 PR domain containing 8 [Homo sapiens]                     30   4.3  
gi|150378439 PR domain containing 8 [Homo sapiens]                     30   4.3  
gi|238624124 trafficking protein particle complex 9 isoform b [H...    29   7.4  
gi|238624122 trafficking protein particle complex 9 isoform a [H...    29   7.4  
gi|33188445 microfilament and actin filament cross-linker protei...    29   9.6  
gi|5453998 importin 7 [Homo sapiens]                                   29   9.6  

>gi|10835059 farnesyltransferase, CAAX box, beta [Homo sapiens]
          Length = 437

 Score =  915 bits (2364), Expect = 0.0
 Identities = 437/437 (100%), Positives = 437/437 (100%)

Query: 1   MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS 60
           MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS
Sbjct: 1   MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS 60

Query: 61  SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ 120
           SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ
Sbjct: 61  SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ 120

Query: 121 IVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQY 180
           IVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQY
Sbjct: 121 IVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQY 180

Query: 181 LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG 240
           LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG
Sbjct: 181 LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG 240

Query: 241 GVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY 300
           GVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY
Sbjct: 241 GVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY 300

Query: 301 SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF 360
           SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF
Sbjct: 301 SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF 360

Query: 361 YHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPV 420
           YHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPV
Sbjct: 361 YHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPV 420

Query: 421 PGFEELKDETSAEPATD 437
           PGFEELKDETSAEPATD
Sbjct: 421 PGFEELKDETSAEPATD 437


>gi|21359854 RAB geranylgeranyltransferase, beta subunit [Homo
           sapiens]
          Length = 331

 Score =  146 bits (369), Expect = 3e-35
 Identities = 96/336 (28%), Positives = 164/336 (48%), Gaps = 36/336 (10%)

Query: 76  EKHFHYLKRGLRQLTDAYECL-DASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQ 134
           EKH  Y+     +  D   C+ +  R    YW L  ++L+ + + ++   ++  F++ CQ
Sbjct: 21  EKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQ-LHRMNREEILAFIKSCQ 79

Query: 135 SPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFLMH 194
              GG     G  PHL  T +AV  L +    ++ ++I+  K+++Y+  L++ DGSF   
Sbjct: 80  HECGGISASIGHDPHLLYTLSAVQILTLY---DSINVIDVNKVVEYVKGLQKEDGSFAGD 136

Query: 195 VGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFC 254
           + GE+D R ++CA +  +L   +     E   E++  C N++GG G  PG E+H G  +C
Sbjct: 137 IWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYC 196

Query: 255 GLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRA 314
               L I  +   +N   L  W+  RQ+   GG  GR  KL D CYS+W    L ++ R 
Sbjct: 197 CTGFLAITSQLHQVNSDLLGWWLCERQLP-SGGLNGRPEKLPDVCYSWWVLASLKIIGRL 255

Query: 315 LHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQ 374
                       HW+  ++ L+ +IL C     GG  D+PG   D +HT + ++GLS+  
Sbjct: 256 ------------HWI-DREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSL-- 300

Query: 375 HFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQ 410
                         + E  ++P +PV+ + P++V+Q
Sbjct: 301 --------------LGEEQIKPVNPVFCM-PEEVLQ 321


>gi|167860116 geranylgeranyltransferase type 1 beta [Homo sapiens]
          Length = 377

 Score =  115 bits (289), Expect = 6e-26
 Identities = 95/335 (28%), Positives = 150/335 (44%), Gaps = 42/335 (12%)

Query: 70  RLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLD--------EPIPQI 121
           RL   R++H  + +R L+ L + Y  L+ SR  + ++ L  L++LD        + I  I
Sbjct: 17  RLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWI 76

Query: 122 VATDVCQFLELCQSPEGGFGGG--------PGQYP---------HLAPTYAAVNALCIIG 164
            +  V    +       GF G         P + P         H+A TY  ++ L I+G
Sbjct: 77  YSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILG 136

Query: 165 TEEAYDIINREKLLQYLYSLKQPDGSFL-MHVGGEVDVRSAYCAASVASLTNIITPDLFE 223
            + +   +N+E  L  L +L+  DGSF  +  G E D+R  YCA+ +  + N  +    +
Sbjct: 137 DDLSR--VNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMK 194

Query: 224 GTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVIL-KRERSLNLKSLLQWVTSRQM 282
               +I R  +++ G+    G+E+HGG TFCG+A+L ++ K E   + K L +      M
Sbjct: 195 KAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIM 254

Query: 283 RFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMC 342
           R + G+ GR NK VD CYSFW    L LL               +  F +   + YIL  
Sbjct: 255 RQQNGYHGRPNKPVDTCYSFWVGATLKLLK-----------IFQYTNFEKN--RNYILST 301

Query: 343 CQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFG 377
                GG    P    D  H  + + GLS+ +  G
Sbjct: 302 QDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESG 336


>gi|76443679 proprotein convertase subtilisin/kexin type 4 [Homo
           sapiens]
          Length = 755

 Score = 30.4 bits (67), Expect = 3.3
 Identities = 25/96 (26%), Positives = 38/96 (39%), Gaps = 9/96 (9%)

Query: 304 QAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHT 363
           Q  L P     LH + +P +    W F QQ LQ  +      P       P  S+ +Y  
Sbjct: 80  QQSLTPHWGHRLHLKKNPKVQ---W-FQQQTLQRRVKRSVVVPTD-----PWFSKQWYMN 130

Query: 364 CYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHP 399
                 LSI Q +  G     +V+ V ++ ++  HP
Sbjct: 131 SEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHP 166


>gi|150378478 PR domain containing 8 [Homo sapiens]
          Length = 689

 Score = 30.0 bits (66), Expect = 4.3
 Identities = 18/65 (27%), Positives = 30/65 (46%)

Query: 371 SIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFEELKDET 430
           + +Q   S + L  +VLG    AL+P HP   +GP ++  A    L   + G  +L    
Sbjct: 500 AFSQPARSFSQLSPLVLGQKLGALEPCHPADGVGPTRLYPAAADPLAVKLQGAADLNGGC 559

Query: 431 SAEPA 435
            + P+
Sbjct: 560 GSLPS 564


>gi|150378439 PR domain containing 8 [Homo sapiens]
          Length = 689

 Score = 30.0 bits (66), Expect = 4.3
 Identities = 18/65 (27%), Positives = 30/65 (46%)

Query: 371 SIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFEELKDET 430
           + +Q   S + L  +VLG    AL+P HP   +GP ++  A    L   + G  +L    
Sbjct: 500 AFSQPARSFSQLSPLVLGQKLGALEPCHPADGVGPTRLYPAAADPLAVKLQGAADLNGGC 559

Query: 431 SAEPA 435
            + P+
Sbjct: 560 GSLPS 564


>gi|238624124 trafficking protein particle complex 9 isoform b [Homo
           sapiens]
          Length = 1148

 Score = 29.3 bits (64), Expect = 7.4
 Identities = 15/45 (33%), Positives = 25/45 (55%), Gaps = 3/45 (6%)

Query: 298 GCYSFWQAGLLPLLHRALHAQ---GDPALSMSHWMFHQQALQEYI 339
           G +  W A  + LLH  ++A    G+PALS+ H  F  Q + +++
Sbjct: 451 GTHRGWAAVQMRLLHELVYASRRMGNPALSVRHLSFLLQTMLDFL 495


>gi|238624122 trafficking protein particle complex 9 isoform a [Homo
           sapiens]
          Length = 1246

 Score = 29.3 bits (64), Expect = 7.4
 Identities = 15/45 (33%), Positives = 25/45 (55%), Gaps = 3/45 (6%)

Query: 298 GCYSFWQAGLLPLLHRALHAQ---GDPALSMSHWMFHQQALQEYI 339
           G +  W A  + LLH  ++A    G+PALS+ H  F  Q + +++
Sbjct: 549 GTHRGWAAVQMRLLHELVYASRRMGNPALSVRHLSFLLQTMLDFL 593


>gi|33188445 microfilament and actin filament cross-linker protein
           isoform a [Homo sapiens]
          Length = 5430

 Score = 28.9 bits (63), Expect = 9.6
 Identities = 19/79 (24%), Positives = 38/79 (48%), Gaps = 10/79 (12%)

Query: 11  CPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSI--EQAKVEEKIQEVFSSYKFNHLV 68
           CPP  +  W+ PL+  +   +++ + D +   V  +  E+ +V++K    F+ +   HL 
Sbjct: 37  CPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKK---TFTKWVNKHL- 92

Query: 69  PRLVLQREKHFHYLKRGLR 87
               ++  KH + L   LR
Sbjct: 93  ----MKVRKHINDLYEDLR 107


>gi|5453998 importin 7 [Homo sapiens]
          Length = 1038

 Score = 28.9 bits (63), Expect = 9.6
 Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 2/50 (4%)

Query: 16   SPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFN 65
            +PVW + L     E  R++LQD  + T+    +A  E K+ E    YKF+
Sbjct: 973  NPVWYQALTHGLNEEQRKQLQD--IATLADQRRAAHESKMIEKHGGYKFS 1020


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.440 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,419,434
Number of Sequences: 37866
Number of extensions: 938163
Number of successful extensions: 2029
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 2002
Number of HSP's gapped (non-prelim): 13
length of query: 437
length of database: 18,247,518
effective HSP length: 105
effective length of query: 332
effective length of database: 14,271,588
effective search space: 4738167216
effective search space used: 4738167216
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.