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Search of human proteins with 115583663
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115583663 alpha-2-plasmin inhibitor [Homo sapiens]
(491 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115583663 alpha-2-plasmin inhibitor [Homo sapiens] 990 0.0
gi|39725934 serine (or cysteine) proteinase inhibitor, clade F (... 173 3e-43
gi|73858570 serpin peptidase inhibitor, clade G, member 1 precur... 166 4e-41
gi|73858568 serpin peptidase inhibitor, clade G, member 1 precur... 166 4e-41
gi|13489087 serine (or cysteine) proteinase inhibitor, clade B (... 157 3e-38
gi|156071456 serpin peptidase inhibitor, clade B, member 11 [Hom... 154 1e-37
gi|4758906 serpin peptidase inhibitor, clade B, member 9 [Homo s... 139 4e-33
gi|50659080 serpin peptidase inhibitor, clade A, member 3 precur... 139 4e-33
gi|4502261 serpin peptidase inhibitor, clade C, member 1 [Homo s... 139 6e-33
gi|73858566 heparin cofactor II precursor [Homo sapiens] 138 1e-32
gi|189163542 serine proteinase inhibitor, clade A, member 1 [Hom... 137 2e-32
gi|189163540 serine proteinase inhibitor, clade A, member 1 [Hom... 137 2e-32
gi|189163538 serine proteinase inhibitor, clade A, member 1 [Hom... 137 2e-32
gi|189163536 serine proteinase inhibitor, clade A, member 1 [Hom... 137 2e-32
gi|189163534 serine proteinase inhibitor, clade A, member 1 [Hom... 137 2e-32
gi|189163532 serine proteinase inhibitor, clade A, member 1 [Hom... 137 2e-32
gi|189163530 serine proteinase inhibitor, clade A, member 1 [Hom... 137 2e-32
gi|189163528 serine proteinase inhibitor, clade A, member 1 [Hom... 137 2e-32
gi|50363219 serine proteinase inhibitor, clade A, member 1 [Homo... 137 2e-32
gi|50363221 serine proteinase inhibitor, clade A, member 1 [Homo... 137 2e-32
gi|50363217 serine proteinase inhibitor, clade A, member 1 [Homo... 137 2e-32
gi|17998551 serine (or cysteine) proteinase inhibitor, clade B (... 135 6e-32
gi|28076869 serine (or cysteine) proteinase inhibitor, clade B (... 134 1e-31
gi|27777657 serine (or cysteine) proteinase inhibitor, clade A (... 134 2e-31
gi|5902072 serine (or cysteine) proteinase inhibitor, clade B (o... 133 3e-31
gi|4826902 serine (or cysteine) proteinase inhibitor, clade B (o... 130 2e-30
gi|5453886 serpin peptidase inhibitor, clade I (pancpin), member... 130 2e-30
gi|38504669 serine (or cysteine) proteinase inhibitor, clade B (... 129 5e-30
gi|38504673 serine (or cysteine) proteinase inhibitor, clade B (... 129 5e-30
gi|170295807 neuroserpin precursor [Homo sapiens] 127 3e-29
>gi|115583663 alpha-2-plasmin inhibitor [Homo sapiens]
Length = 491
Score = 990 bits (2560), Expect = 0.0
Identities = 491/491 (100%), Positives = 491/491 (100%)
Query: 1 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ 60
MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ
Sbjct: 1 MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQ 60
Query: 61 TALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHL 120
TALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHL
Sbjct: 61 TALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHL 120
Query: 121 ALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE 180
ALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE
Sbjct: 121 ALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE 180
Query: 181 QSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGF 240
QSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGF
Sbjct: 181 QSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGF 240
Query: 241 WRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVV 300
WRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVV
Sbjct: 241 WRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVV 300
Query: 301 LVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF 360
LVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF
Sbjct: 301 LVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF 360
Query: 361 QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIF 420
QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIF
Sbjct: 361 QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIF 420
Query: 421 EDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPM 480
EDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPM
Sbjct: 421 EDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPM 480
Query: 481 EEDYPQFGSPK 491
EEDYPQFGSPK
Sbjct: 481 EEDYPQFGSPK 491
>gi|39725934 serine (or cysteine) proteinase inhibitor, clade F
(alpha-2 antiplasmin, pigment epithelium derived
factor), member 1 [Homo sapiens]
Length = 418
Score = 173 bits (439), Expect = 3e-43
Identities = 110/367 (29%), Positives = 190/367 (51%), Gaps = 13/367 (3%)
Query: 80 HRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLHAG 139
++LA A+ F DL+ + + TS N++LSPLSVA ALS L+LGA+ T + + L+
Sbjct: 52 NKLAAAVSNFGYDLYRVRSSTSPTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYD 111
Query: 140 --SGPCLPHLLSRLCQDLGPGAFRL--AARMYLQKGFPIKEDFLEQSEQLFGAKPVSLTG 195
S P + L + L A+R+ +K IK F+ E+ +G +P LTG
Sbjct: 112 LISSPDIHGTYKELLDTVTAPQKNLKSASRIVFEKKLRIKSSFVAPLEKSYGTRPRVLTG 171
Query: 196 KQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWRNKFDPSLTQRDSF 255
DL IN WV+ +GK+ +P++ +LLL HF+G W KFD T + F
Sbjct: 172 NPRLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGVAHFKGQWVTKFDSRKTSLEDF 231
Query: 256 HLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLVPTHFEWNVSQVLA 315
+LDE+ TV V MM LR+ L ++A P +MS + +P N++ +
Sbjct: 232 YLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSIIFFLPLKVTQNLTLIEE 291
Query: 316 NLSWDTLHPPLVWERPTK-----VRLPKLYLKHQMDLVATLSQLGLQELFQAPDLRGISE 370
+L+ + +H +R K + +PKL L ++ ++ +L ++ LQ LF +PD I+
Sbjct: 292 SLTSEFIHD---IDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLFDSPDFSKITG 348
Query: 371 QSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLS-SFSVNRPFLFFIFEDTTGLPLF 429
+ + ++ V+H++ E +E G + + + ++ + +N+PF+F + + TG LF
Sbjct: 349 KPIKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLNQPFIFVLRDTDTGALLF 408
Query: 430 VGSVRNP 436
+G + +P
Sbjct: 409 IGKILDP 415
>gi|73858570 serpin peptidase inhibitor, clade G, member 1 precursor
[Homo sapiens]
Length = 500
Score = 166 bits (420), Expect = 4e-41
Identities = 116/409 (28%), Positives = 204/409 (49%), Gaps = 13/409 (3%)
Query: 36 TSGPNQEQVSPLTLLKLGNQ-EPGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLF 94
T+ P + P T L + +P + P +CS + L A++ F+ L+
Sbjct: 95 TTQPTIQPTQPTTQLPTDSPTQPTTGSFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLY 154
Query: 95 -SLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQ 153
+ A N+ SP S+A L+ + LGA +T L+ +L H +
Sbjct: 155 HAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDFTCVHQALKGFT 214
Query: 154 DLGPGAFRLAARMYLQKGFPIKEDFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATE 213
G + ++++ I++ F+ S L+ + P L+ + +L IN WV + T
Sbjct: 215 TKGVTS---VSQIFHSPDLAIRDTFVNASRTLYSSSPRVLSNNSDANLELINTWVAKNTN 271
Query: 214 GKIQEFLSGLPEDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTY 273
KI L LP DT L+LLNAI+ W+ FDP T+ + FH + + V MM ++ Y
Sbjct: 272 NKISRLLDSLPSDTRLVLLNAIYLSAKWKTTFDPKKTRMEPFHF-KNSVIKVPMMNSKKY 330
Query: 274 PLRWFLLEQPEIQVAHFPFKNNMSFVVLVPTHFEW---NVSQVLANLSWDTLHPPLVWER 330
P+ F+ + + +V +N+S V+LVP + + ++ Q L+ + + L +
Sbjct: 331 PVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLKHRLEDMEQALSPSVFKAIMEKLEMSK 390
Query: 331 --PTKVRLPKLYLKHQMDLVATLSQLGLQELFQAPDLRGISEQ-SLVVSGVQHQSTLELS 387
PT + LP++ + D+++ + +L + +L G++E L VS +QHQ+ LEL+
Sbjct: 391 FQPTLLTLPRIKVTTSQDMLSIMEKLEFFDFSYDLNLCGLTEDPDLQVSAMQHQTVLELT 450
Query: 388 EVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
E GVEAAAA++I+++R +L F V +PFLF +++ P+F+G V +P
Sbjct: 451 ETGVEAAAASAISVAR-TLLVFEVQQPFLFVLWDQQHKFPVFMGRVYDP 498
>gi|73858568 serpin peptidase inhibitor, clade G, member 1 precursor
[Homo sapiens]
Length = 500
Score = 166 bits (420), Expect = 4e-41
Identities = 116/409 (28%), Positives = 204/409 (49%), Gaps = 13/409 (3%)
Query: 36 TSGPNQEQVSPLTLLKLGNQ-EPGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLF 94
T+ P + P T L + +P + P +CS + L A++ F+ L+
Sbjct: 95 TTQPTIQPTQPTTQLPTDSPTQPTTGSFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLY 154
Query: 95 -SLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQ 153
+ A N+ SP S+A L+ + LGA +T L+ +L H +
Sbjct: 155 HAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDFTCVHQALKGFT 214
Query: 154 DLGPGAFRLAARMYLQKGFPIKEDFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATE 213
G + ++++ I++ F+ S L+ + P L+ + +L IN WV + T
Sbjct: 215 TKGVTS---VSQIFHSPDLAIRDTFVNASRTLYSSSPRVLSNNSDANLELINTWVAKNTN 271
Query: 214 GKIQEFLSGLPEDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTY 273
KI L LP DT L+LLNAI+ W+ FDP T+ + FH + + V MM ++ Y
Sbjct: 272 NKISRLLDSLPSDTRLVLLNAIYLSAKWKTTFDPKKTRMEPFHF-KNSVIKVPMMNSKKY 330
Query: 274 PLRWFLLEQPEIQVAHFPFKNNMSFVVLVPTHFEW---NVSQVLANLSWDTLHPPLVWER 330
P+ F+ + + +V +N+S V+LVP + + ++ Q L+ + + L +
Sbjct: 331 PVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLKHRLEDMEQALSPSVFKAIMEKLEMSK 390
Query: 331 --PTKVRLPKLYLKHQMDLVATLSQLGLQELFQAPDLRGISEQ-SLVVSGVQHQSTLELS 387
PT + LP++ + D+++ + +L + +L G++E L VS +QHQ+ LEL+
Sbjct: 391 FQPTLLTLPRIKVTTSQDMLSIMEKLEFFDFSYDLNLCGLTEDPDLQVSAMQHQTVLELT 450
Query: 388 EVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
E GVEAAAA++I+++R +L F V +PFLF +++ P+F+G V +P
Sbjct: 451 ETGVEAAAASAISVAR-TLLVFEVQQPFLFVLWDQQHKFPVFMGRVYDP 498
>gi|13489087 serine (or cysteine) proteinase inhibitor, clade B
(ovalbumin), member 1 [Homo sapiens]
Length = 379
Score = 157 bits (396), Expect = 3e-38
Identities = 119/381 (31%), Positives = 204/381 (53%), Gaps = 29/381 (7%)
Query: 81 RLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGS 140
+L+ A F DLF +++ + N+ +SP S++ A++ + LG + +T +L + H +
Sbjct: 3 QLSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHFNT 62
Query: 141 GPCLPHLLSRLCQDLGP-GA---FRLAARMYLQKGFPIKEDFLEQSEQLFGA--KPVSLT 194
+ L D+ GA +LA R+Y +K + +FL +++ +GA V
Sbjct: 63 VEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQ 122
Query: 195 GKQEDDLANINQWVKEATEGKIQEFL-SGLPED-TVLLLLNAIHFQGFWRNKFDPSLTQR 252
ED INQWVK TEGKI E L SG+ ++ T L+L+NAI+F+G W++KF T
Sbjct: 123 HASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTN 182
Query: 253 DSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFK-NNMSFVVLVPTHFE---W 308
F L+++ V+MM + + +E + +V P++ +S V+L+P E
Sbjct: 183 APFRLNKKDRKTVKMMYQKK-KFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDEST 241
Query: 309 NVSQVLANLSWDTLHPPLVWERP-------TKVRLPKLYLKHQMDLVATLSQLGLQELFQ 361
+ ++ L+ + LH W +P V LP+ L+ L + L++LG+Q+LF
Sbjct: 242 GLKKIEEQLTLEKLHE---WTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFN 298
Query: 362 A--PDLRGIS-EQSLVVSGVQHQSTLELSEVGVEAAAATS-IAMSRMSL--SSFSVNRPF 415
+ DL G+S + + +S + H+S +E++E G EAAAAT+ IA M + +F+ + PF
Sbjct: 299 SSKADLSGMSGARDIFISKIVHKSFVEVNEEGTEAAAATAGIATFCMLMPEENFTADHPF 358
Query: 416 LFFIFEDTTGLPLFVGSVRNP 436
LFFI +++G LF+G +P
Sbjct: 359 LFFIRHNSSGSILFLGRFSSP 379
>gi|156071456 serpin peptidase inhibitor, clade B, member 11 [Homo
sapiens]
Length = 392
Score = 154 bits (390), Expect = 1e-37
Identities = 124/392 (31%), Positives = 197/392 (50%), Gaps = 40/392 (10%)
Query: 82 LARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLHAG-- 139
L+ A + F D+F + + N+ S LS+ ALS + LGA+ T ++L++VLH
Sbjct: 4 LSTANVEFCLDVFKELNSNNIGDNIFFSSLSLLYALSMVLLGARGETEEQLEKVLHFSHT 63
Query: 140 ----------SGPCLPH---------LLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLE 180
S C S++ Q +A R+Y K + +L
Sbjct: 64 VDSLKPGFKDSPKCSQAGRIHSEFGVEFSQINQPDSNCTLSIANRLYGTKTMAFHQQYLS 123
Query: 181 QSEQLFGAKPVSLTGKQ--EDDLANINQWVKEATEGKIQEFL--SGLPEDTVLLLLNAIH 236
SE+ + A+ ++ +Q E+ IN WV+ T GK+ S + +V++L+NAI+
Sbjct: 124 CSEKWYQARLQTVDFEQSTEETRKTINAWVENKTNGKVANLFGKSTIDPSSVMVLVNAIY 183
Query: 237 FQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMM-QARTYPLRWFLLEQPEIQVAHFPFKNN 295
F+G W+NKF T + F L E V VEMM Q T+ L + +++P++QV P+ NN
Sbjct: 184 FKGQWQNKFQVRETVKSPFQLSEGKNVTVEMMYQIGTFKLAF--VKEPQMQVLELPYVNN 241
Query: 296 -MSFVVLVPTHFEWNVSQVLANLSWDTLH----PPLVWERPTKVRLPKLYLKHQMDLVAT 350
+S ++L+P N+ Q+ L+ T H + ER +V LP+ L+ + +L +
Sbjct: 242 KLSMIILLPVGIA-NLKQIEKQLNSGTFHEWTSSSNMMEREVEVHLPRFKLETKYELNSL 300
Query: 351 LSQLGLQELFQ--APDLRGIS-EQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSL- 406
L LG+ +LF DL G+S + L +S H+S L++SE G EAAAAT +++ SL
Sbjct: 301 LKSLGVTDLFNQVKADLSGMSPTKGLYLSKAIHKSYLDVSEEGTEAAAATGDSIAVKSLP 360
Query: 407 --SSFSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
+ F N PFLFFI T LF G + +P
Sbjct: 361 MRAQFKANHPFLFFIRHTHTNTILFCGKLASP 392
>gi|4758906 serpin peptidase inhibitor, clade B, member 9 [Homo
sapiens]
Length = 376
Score = 139 bits (351), Expect = 4e-33
Identities = 113/379 (29%), Positives = 188/379 (49%), Gaps = 30/379 (7%)
Query: 82 LARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGSG 141
L+ A F L ++ Q + N+ SP+S++ AL+ + LGA+ +T ++ Q L +
Sbjct: 4 LSNASGTFAIRLLKILCQDNPSHNVFCSPVSISSALAMVLLGAKGNTATQMAQALSLNTE 63
Query: 142 PCLPHLLSRLCQDLGPGA----FRLAARMYLQKGFPIKEDFLEQSEQLFGA--KPVSLTG 195
+ L ++ R A R++ +K F E Q + A K +S
Sbjct: 64 EDIHRAFQSLLTEVNKAGTQYLLRTANRLFGEKTCQFLSTFKESCLQFYHAELKELSFIR 123
Query: 196 KQEDDLANINQWVKEATEGKIQEFLSG--LPEDTVLLLLNAIHFQGFWRNKFDPSLTQRD 253
E+ +IN WV + TEGKI+E L G + +T L+L+NAI+F+G W FD + T+
Sbjct: 124 AAEESRKHINTWVSKKTEGKIEELLPGSSIDAETRLVLVNAIYFKGKWNEPFDETYTREM 183
Query: 254 SFHLDEQFTVPVEMM-QARTYPLRWFLLEQPEIQVAHFPF-KNNMSFVVLVPTHFEWNVS 311
F ++++ PV+MM Q T+ L + + Q+ P+ + +S +VL+P +S
Sbjct: 184 PFKINQEEQRPVQMMYQEATFKLAH--VGEVRAQLLELPYARKELSLLVLLPDD-GVELS 240
Query: 312 QVLANLSWDTLHPPLVWERP-------TKVRLPKLYLKHQMDLVATLSQLGLQELFQ--A 362
V +L+++ L W +P +V LPK L+ D+ + L LG+ + FQ
Sbjct: 241 TVEKSLTFEKL---TAWTKPDCMKSTEVEVLLPKFKLQEDYDMESVLRHLGIVDAFQQGK 297
Query: 363 PDLRGIS-EQSLVVSGVQHQSTLELSEVGVEAAAATS-IAMSRMSLSS---FSVNRPFLF 417
DL +S E+ L +S H+S +E++E G EAAAA+S ++ + S F + PFLF
Sbjct: 298 ADLSAMSAERDLCLSKFVHKSFVEVNEEGTEAAAASSCFVVAECCMESGPRFCADHPFLF 357
Query: 418 FIFEDTTGLPLFVGSVRNP 436
FI + LF G +P
Sbjct: 358 FIRHNRANSILFCGRFSSP 376
>gi|50659080 serpin peptidase inhibitor, clade A, member 3 precursor
[Homo sapiens]
Length = 423
Score = 139 bits (351), Expect = 4e-33
Identities = 111/375 (29%), Positives = 182/375 (48%), Gaps = 23/375 (6%)
Query: 82 LARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQR--------LQ 133
LA A + F L+ + + N+I SPLS++ AL+ L+LGA N TL L
Sbjct: 49 LASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLT 108
Query: 134 QVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQSEQLFGAKPVSL 193
+ A HLL L Q + M++++ + + F E +++L+G++ +
Sbjct: 109 ETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFA- 167
Query: 194 TGKQEDDLAN--INQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWRNKFDPSLTQ 251
T Q+ A IN +VK T GKI + + L T+++L+N I F+ W FDP T
Sbjct: 168 TDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKWEMPFDPQDTH 227
Query: 252 RDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLVPTHFEWNVS 311
+ F+L ++ V V MM + +F E+ V + N S + ++P + +
Sbjct: 228 QSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVELKYTGNASALFILPD--QDKME 285
Query: 312 QVLANLSWDTL---HPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELFQA-PDLRG 367
+V A L +TL L + ++ LPK + +L L QLG++E F + DL G
Sbjct: 286 EVEAMLLPETLKRWRDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSG 345
Query: 368 IS-EQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSL-----SSFSVNRPFLFFIFE 421
I+ ++L VS V H++ L++ E G EA+AAT++ ++ +S + NRPFL I
Sbjct: 346 ITGARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRFNRPFLMIIVP 405
Query: 422 DTTGLPLFVGSVRNP 436
T F+ V NP
Sbjct: 406 TDTQNIFFMSKVTNP 420
>gi|4502261 serpin peptidase inhibitor, clade C, member 1 [Homo
sapiens]
Length = 464
Score = 139 bits (350), Expect = 6e-33
Identities = 117/396 (29%), Positives = 193/396 (48%), Gaps = 32/396 (8%)
Query: 71 SRDPTPEQTHR----LARAMMAFTADLFSLVAQTSTC-PNLILSPLSVALALSHLALGAQ 125
S PE T+R L++A F + +A + N+ LSPLS++ A + LGA
Sbjct: 68 SEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGAC 127
Query: 126 NHTLQRLQQVLHAGSGP---------CLPHLLSRLCQDLGPGAFRLAA-RMYLQKGFPIK 175
N TLQ+L +V + L RL + + ++A R++ K
Sbjct: 128 NDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFN 187
Query: 176 EDFLEQSEQLFGAK--PVSLTGKQEDDLANINQWVKEATEGKIQEFL--SGLPEDTVLLL 231
E + + SE ++GAK P+ E A IN+WV TEG+I + + + E TVL+L
Sbjct: 188 ETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVL 247
Query: 232 LNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFP 291
+N I+F+G W++KF P T+++ F+ + + MM + R+ + + QV P
Sbjct: 248 VNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMY-QEGKFRYRRVAE-GTQVLELP 305
Query: 292 FKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPL--VWERPTKVRLPKLYLKHQMDLVA 349
FK + +VL+ E ++++V L+ + L L + E V +P+ ++ L
Sbjct: 306 FKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKE 365
Query: 350 TLSQLGLQELF-----QAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRM 404
L +GL +LF + P + L VS H++ LE++E G EAAA+T++ ++
Sbjct: 366 QLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGR 425
Query: 405 SLS----SFSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
SL+ +F NRPFL FI E +F+G V NP
Sbjct: 426 SLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANP 461
>gi|73858566 heparin cofactor II precursor [Homo sapiens]
Length = 499
Score = 138 bits (347), Expect = 1e-32
Identities = 102/366 (27%), Positives = 184/366 (50%), Gaps = 35/366 (9%)
Query: 99 QTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLH------AGSG---PCLPHLLS 149
Q +T N+ ++P+ ++ A+ ++LG + T +++ +LH A S + +L
Sbjct: 144 QVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFR 203
Query: 150 RLCQDLGPGAFRLAAR----MYLQKGFPIKEDFLEQSEQLFGAKPVSLTGKQEDDLANIN 205
+L L F R +Y+QK FPI DF + + + A+ ++ N
Sbjct: 204 KLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTN 263
Query: 206 QWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPV 265
+ + T+G I++ L + T +++LN I+F+G W NKF +T +F L+E+ V V
Sbjct: 264 NHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKV 323
Query: 266 EMMQARTYPLRWFLL---EQPEIQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTL 322
MMQ + FL ++ + + + +S +++VP H + + A L+
Sbjct: 324 SMMQTKGN----FLAANDQELDCDILQLEYVGGISMLIVVP-HKMSGMKTLEAQLT---- 374
Query: 323 HPPLV--WE-----RPTKVRLPKLYLKHQMDLVATLSQLGLQELF-QAPDLRGISEQSLV 374
P +V W+ R +V LPK L+ +LV +L +G++ LF + ++ GIS+Q +
Sbjct: 375 -PRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIA 433
Query: 375 VSGVQHQSTLELSEVGVEAAAATSIAMSRMSLS-SFSVNRPFLFFIFEDTTGLPLFVGSV 433
+ +HQ T+ ++E G +A T++ +S F+V+RPFLF I+E T LF+G V
Sbjct: 434 IDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRV 493
Query: 434 RNPNPS 439
NP+ S
Sbjct: 494 ANPSRS 499
>gi|189163542 serine proteinase inhibitor, clade A, member 1 [Homo
sapiens]
Length = 418
Score = 137 bits (345), Expect = 2e-32
Identities = 112/397 (28%), Positives = 187/397 (47%), Gaps = 21/397 (5%)
Query: 55 QEPGGQTALKSPPGVCSRD-PTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSV 113
++P G A K+ +D PT +++ + F L+ +A S N+ SP+S+
Sbjct: 25 EDPQGDAAQKTDTSHHDQDHPT---FNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSI 81
Query: 114 ALALSHLALGAQNHTLQR--------LQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAAR 165
A A + L+LG + T L ++ A LL L Q
Sbjct: 82 ATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNG 141
Query: 166 MYLQKGFPIKEDFLEQSEQLFGAKPVSLT-GKQEDDLANINQWVKEATEGKIQEFLSGLP 224
++L +G + + FLE ++L+ ++ ++ G E+ IN +V++ T+GKI + + L
Sbjct: 142 LFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELD 201
Query: 225 EDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPE 284
DTV L+N I F+G W F+ T+ + FH+D+ TV V MM+ R ++
Sbjct: 202 RDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMK-RLGMFNIQHCKKLS 260
Query: 285 IQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWE--RPTKVRLPKLYLK 342
V + N + + +P E + + L+ D + L E R + LPKL +
Sbjct: 261 SWVLLMKYLGNATAIFFLPD--EGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318
Query: 343 HQMDLVATLSQLGLQELF-QAPDLRGISEQS-LVVSGVQHQSTLELSEVGVEAAAATSIA 400
DL + L QLG+ ++F DL G++E++ L +S H++ L + E G EAA A +
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLE 378
Query: 401 MSRMSL-SSFSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
MS+ N+PF+F + E T PLF+G V NP
Sbjct: 379 AIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNP 415
>gi|189163540 serine proteinase inhibitor, clade A, member 1 [Homo
sapiens]
Length = 418
Score = 137 bits (345), Expect = 2e-32
Identities = 112/397 (28%), Positives = 187/397 (47%), Gaps = 21/397 (5%)
Query: 55 QEPGGQTALKSPPGVCSRD-PTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSV 113
++P G A K+ +D PT +++ + F L+ +A S N+ SP+S+
Sbjct: 25 EDPQGDAAQKTDTSHHDQDHPT---FNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSI 81
Query: 114 ALALSHLALGAQNHTLQR--------LQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAAR 165
A A + L+LG + T L ++ A LL L Q
Sbjct: 82 ATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNG 141
Query: 166 MYLQKGFPIKEDFLEQSEQLFGAKPVSLT-GKQEDDLANINQWVKEATEGKIQEFLSGLP 224
++L +G + + FLE ++L+ ++ ++ G E+ IN +V++ T+GKI + + L
Sbjct: 142 LFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELD 201
Query: 225 EDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPE 284
DTV L+N I F+G W F+ T+ + FH+D+ TV V MM+ R ++
Sbjct: 202 RDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMK-RLGMFNIQHCKKLS 260
Query: 285 IQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWE--RPTKVRLPKLYLK 342
V + N + + +P E + + L+ D + L E R + LPKL +
Sbjct: 261 SWVLLMKYLGNATAIFFLPD--EGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318
Query: 343 HQMDLVATLSQLGLQELF-QAPDLRGISEQS-LVVSGVQHQSTLELSEVGVEAAAATSIA 400
DL + L QLG+ ++F DL G++E++ L +S H++ L + E G EAA A +
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLE 378
Query: 401 MSRMSL-SSFSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
MS+ N+PF+F + E T PLF+G V NP
Sbjct: 379 AIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNP 415
>gi|189163538 serine proteinase inhibitor, clade A, member 1 [Homo
sapiens]
Length = 418
Score = 137 bits (345), Expect = 2e-32
Identities = 112/397 (28%), Positives = 187/397 (47%), Gaps = 21/397 (5%)
Query: 55 QEPGGQTALKSPPGVCSRD-PTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSV 113
++P G A K+ +D PT +++ + F L+ +A S N+ SP+S+
Sbjct: 25 EDPQGDAAQKTDTSHHDQDHPT---FNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSI 81
Query: 114 ALALSHLALGAQNHTLQR--------LQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAAR 165
A A + L+LG + T L ++ A LL L Q
Sbjct: 82 ATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNG 141
Query: 166 MYLQKGFPIKEDFLEQSEQLFGAKPVSLT-GKQEDDLANINQWVKEATEGKIQEFLSGLP 224
++L +G + + FLE ++L+ ++ ++ G E+ IN +V++ T+GKI + + L
Sbjct: 142 LFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELD 201
Query: 225 EDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPE 284
DTV L+N I F+G W F+ T+ + FH+D+ TV V MM+ R ++
Sbjct: 202 RDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMK-RLGMFNIQHCKKLS 260
Query: 285 IQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWE--RPTKVRLPKLYLK 342
V + N + + +P E + + L+ D + L E R + LPKL +
Sbjct: 261 SWVLLMKYLGNATAIFFLPD--EGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318
Query: 343 HQMDLVATLSQLGLQELF-QAPDLRGISEQS-LVVSGVQHQSTLELSEVGVEAAAATSIA 400
DL + L QLG+ ++F DL G++E++ L +S H++ L + E G EAA A +
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLE 378
Query: 401 MSRMSL-SSFSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
MS+ N+PF+F + E T PLF+G V NP
Sbjct: 379 AIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNP 415
>gi|189163536 serine proteinase inhibitor, clade A, member 1 [Homo
sapiens]
Length = 418
Score = 137 bits (345), Expect = 2e-32
Identities = 112/397 (28%), Positives = 187/397 (47%), Gaps = 21/397 (5%)
Query: 55 QEPGGQTALKSPPGVCSRD-PTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSV 113
++P G A K+ +D PT +++ + F L+ +A S N+ SP+S+
Sbjct: 25 EDPQGDAAQKTDTSHHDQDHPT---FNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSI 81
Query: 114 ALALSHLALGAQNHTLQR--------LQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAAR 165
A A + L+LG + T L ++ A LL L Q
Sbjct: 82 ATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNG 141
Query: 166 MYLQKGFPIKEDFLEQSEQLFGAKPVSLT-GKQEDDLANINQWVKEATEGKIQEFLSGLP 224
++L +G + + FLE ++L+ ++ ++ G E+ IN +V++ T+GKI + + L
Sbjct: 142 LFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELD 201
Query: 225 EDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPE 284
DTV L+N I F+G W F+ T+ + FH+D+ TV V MM+ R ++
Sbjct: 202 RDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMK-RLGMFNIQHCKKLS 260
Query: 285 IQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWE--RPTKVRLPKLYLK 342
V + N + + +P E + + L+ D + L E R + LPKL +
Sbjct: 261 SWVLLMKYLGNATAIFFLPD--EGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318
Query: 343 HQMDLVATLSQLGLQELF-QAPDLRGISEQS-LVVSGVQHQSTLELSEVGVEAAAATSIA 400
DL + L QLG+ ++F DL G++E++ L +S H++ L + E G EAA A +
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLE 378
Query: 401 MSRMSL-SSFSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
MS+ N+PF+F + E T PLF+G V NP
Sbjct: 379 AIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNP 415
>gi|189163534 serine proteinase inhibitor, clade A, member 1 [Homo
sapiens]
Length = 418
Score = 137 bits (345), Expect = 2e-32
Identities = 112/397 (28%), Positives = 187/397 (47%), Gaps = 21/397 (5%)
Query: 55 QEPGGQTALKSPPGVCSRD-PTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSV 113
++P G A K+ +D PT +++ + F L+ +A S N+ SP+S+
Sbjct: 25 EDPQGDAAQKTDTSHHDQDHPT---FNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSI 81
Query: 114 ALALSHLALGAQNHTLQR--------LQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAAR 165
A A + L+LG + T L ++ A LL L Q
Sbjct: 82 ATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNG 141
Query: 166 MYLQKGFPIKEDFLEQSEQLFGAKPVSLT-GKQEDDLANINQWVKEATEGKIQEFLSGLP 224
++L +G + + FLE ++L+ ++ ++ G E+ IN +V++ T+GKI + + L
Sbjct: 142 LFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELD 201
Query: 225 EDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPE 284
DTV L+N I F+G W F+ T+ + FH+D+ TV V MM+ R ++
Sbjct: 202 RDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMK-RLGMFNIQHCKKLS 260
Query: 285 IQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWE--RPTKVRLPKLYLK 342
V + N + + +P E + + L+ D + L E R + LPKL +
Sbjct: 261 SWVLLMKYLGNATAIFFLPD--EGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318
Query: 343 HQMDLVATLSQLGLQELF-QAPDLRGISEQS-LVVSGVQHQSTLELSEVGVEAAAATSIA 400
DL + L QLG+ ++F DL G++E++ L +S H++ L + E G EAA A +
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLE 378
Query: 401 MSRMSL-SSFSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
MS+ N+PF+F + E T PLF+G V NP
Sbjct: 379 AIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNP 415
>gi|189163532 serine proteinase inhibitor, clade A, member 1 [Homo
sapiens]
Length = 418
Score = 137 bits (345), Expect = 2e-32
Identities = 112/397 (28%), Positives = 187/397 (47%), Gaps = 21/397 (5%)
Query: 55 QEPGGQTALKSPPGVCSRD-PTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSV 113
++P G A K+ +D PT +++ + F L+ +A S N+ SP+S+
Sbjct: 25 EDPQGDAAQKTDTSHHDQDHPT---FNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSI 81
Query: 114 ALALSHLALGAQNHTLQR--------LQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAAR 165
A A + L+LG + T L ++ A LL L Q
Sbjct: 82 ATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNG 141
Query: 166 MYLQKGFPIKEDFLEQSEQLFGAKPVSLT-GKQEDDLANINQWVKEATEGKIQEFLSGLP 224
++L +G + + FLE ++L+ ++ ++ G E+ IN +V++ T+GKI + + L
Sbjct: 142 LFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELD 201
Query: 225 EDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPE 284
DTV L+N I F+G W F+ T+ + FH+D+ TV V MM+ R ++
Sbjct: 202 RDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMK-RLGMFNIQHCKKLS 260
Query: 285 IQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWE--RPTKVRLPKLYLK 342
V + N + + +P E + + L+ D + L E R + LPKL +
Sbjct: 261 SWVLLMKYLGNATAIFFLPD--EGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318
Query: 343 HQMDLVATLSQLGLQELF-QAPDLRGISEQS-LVVSGVQHQSTLELSEVGVEAAAATSIA 400
DL + L QLG+ ++F DL G++E++ L +S H++ L + E G EAA A +
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLE 378
Query: 401 MSRMSL-SSFSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
MS+ N+PF+F + E T PLF+G V NP
Sbjct: 379 AIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNP 415
>gi|189163530 serine proteinase inhibitor, clade A, member 1 [Homo
sapiens]
Length = 418
Score = 137 bits (345), Expect = 2e-32
Identities = 112/397 (28%), Positives = 187/397 (47%), Gaps = 21/397 (5%)
Query: 55 QEPGGQTALKSPPGVCSRD-PTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSV 113
++P G A K+ +D PT +++ + F L+ +A S N+ SP+S+
Sbjct: 25 EDPQGDAAQKTDTSHHDQDHPT---FNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSI 81
Query: 114 ALALSHLALGAQNHTLQR--------LQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAAR 165
A A + L+LG + T L ++ A LL L Q
Sbjct: 82 ATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNG 141
Query: 166 MYLQKGFPIKEDFLEQSEQLFGAKPVSLT-GKQEDDLANINQWVKEATEGKIQEFLSGLP 224
++L +G + + FLE ++L+ ++ ++ G E+ IN +V++ T+GKI + + L
Sbjct: 142 LFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELD 201
Query: 225 EDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPE 284
DTV L+N I F+G W F+ T+ + FH+D+ TV V MM+ R ++
Sbjct: 202 RDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMK-RLGMFNIQHCKKLS 260
Query: 285 IQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWE--RPTKVRLPKLYLK 342
V + N + + +P E + + L+ D + L E R + LPKL +
Sbjct: 261 SWVLLMKYLGNATAIFFLPD--EGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318
Query: 343 HQMDLVATLSQLGLQELF-QAPDLRGISEQS-LVVSGVQHQSTLELSEVGVEAAAATSIA 400
DL + L QLG+ ++F DL G++E++ L +S H++ L + E G EAA A +
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLE 378
Query: 401 MSRMSL-SSFSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
MS+ N+PF+F + E T PLF+G V NP
Sbjct: 379 AIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNP 415
>gi|189163528 serine proteinase inhibitor, clade A, member 1 [Homo
sapiens]
Length = 418
Score = 137 bits (345), Expect = 2e-32
Identities = 112/397 (28%), Positives = 187/397 (47%), Gaps = 21/397 (5%)
Query: 55 QEPGGQTALKSPPGVCSRD-PTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSV 113
++P G A K+ +D PT +++ + F L+ +A S N+ SP+S+
Sbjct: 25 EDPQGDAAQKTDTSHHDQDHPT---FNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSI 81
Query: 114 ALALSHLALGAQNHTLQR--------LQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAAR 165
A A + L+LG + T L ++ A LL L Q
Sbjct: 82 ATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNG 141
Query: 166 MYLQKGFPIKEDFLEQSEQLFGAKPVSLT-GKQEDDLANINQWVKEATEGKIQEFLSGLP 224
++L +G + + FLE ++L+ ++ ++ G E+ IN +V++ T+GKI + + L
Sbjct: 142 LFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELD 201
Query: 225 EDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPE 284
DTV L+N I F+G W F+ T+ + FH+D+ TV V MM+ R ++
Sbjct: 202 RDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMK-RLGMFNIQHCKKLS 260
Query: 285 IQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWE--RPTKVRLPKLYLK 342
V + N + + +P E + + L+ D + L E R + LPKL +
Sbjct: 261 SWVLLMKYLGNATAIFFLPD--EGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318
Query: 343 HQMDLVATLSQLGLQELF-QAPDLRGISEQS-LVVSGVQHQSTLELSEVGVEAAAATSIA 400
DL + L QLG+ ++F DL G++E++ L +S H++ L + E G EAA A +
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLE 378
Query: 401 MSRMSL-SSFSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
MS+ N+PF+F + E T PLF+G V NP
Sbjct: 379 AIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNP 415
>gi|50363219 serine proteinase inhibitor, clade A, member 1 [Homo
sapiens]
Length = 418
Score = 137 bits (345), Expect = 2e-32
Identities = 112/397 (28%), Positives = 187/397 (47%), Gaps = 21/397 (5%)
Query: 55 QEPGGQTALKSPPGVCSRD-PTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSV 113
++P G A K+ +D PT +++ + F L+ +A S N+ SP+S+
Sbjct: 25 EDPQGDAAQKTDTSHHDQDHPT---FNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSI 81
Query: 114 ALALSHLALGAQNHTLQR--------LQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAAR 165
A A + L+LG + T L ++ A LL L Q
Sbjct: 82 ATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNG 141
Query: 166 MYLQKGFPIKEDFLEQSEQLFGAKPVSLT-GKQEDDLANINQWVKEATEGKIQEFLSGLP 224
++L +G + + FLE ++L+ ++ ++ G E+ IN +V++ T+GKI + + L
Sbjct: 142 LFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELD 201
Query: 225 EDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPE 284
DTV L+N I F+G W F+ T+ + FH+D+ TV V MM+ R ++
Sbjct: 202 RDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMK-RLGMFNIQHCKKLS 260
Query: 285 IQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWE--RPTKVRLPKLYLK 342
V + N + + +P E + + L+ D + L E R + LPKL +
Sbjct: 261 SWVLLMKYLGNATAIFFLPD--EGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318
Query: 343 HQMDLVATLSQLGLQELF-QAPDLRGISEQS-LVVSGVQHQSTLELSEVGVEAAAATSIA 400
DL + L QLG+ ++F DL G++E++ L +S H++ L + E G EAA A +
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLE 378
Query: 401 MSRMSL-SSFSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
MS+ N+PF+F + E T PLF+G V NP
Sbjct: 379 AIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNP 415
>gi|50363221 serine proteinase inhibitor, clade A, member 1 [Homo
sapiens]
Length = 418
Score = 137 bits (345), Expect = 2e-32
Identities = 112/397 (28%), Positives = 187/397 (47%), Gaps = 21/397 (5%)
Query: 55 QEPGGQTALKSPPGVCSRD-PTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSV 113
++P G A K+ +D PT +++ + F L+ +A S N+ SP+S+
Sbjct: 25 EDPQGDAAQKTDTSHHDQDHPT---FNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSI 81
Query: 114 ALALSHLALGAQNHTLQR--------LQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAAR 165
A A + L+LG + T L ++ A LL L Q
Sbjct: 82 ATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNG 141
Query: 166 MYLQKGFPIKEDFLEQSEQLFGAKPVSLT-GKQEDDLANINQWVKEATEGKIQEFLSGLP 224
++L +G + + FLE ++L+ ++ ++ G E+ IN +V++ T+GKI + + L
Sbjct: 142 LFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELD 201
Query: 225 EDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPE 284
DTV L+N I F+G W F+ T+ + FH+D+ TV V MM+ R ++
Sbjct: 202 RDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMK-RLGMFNIQHCKKLS 260
Query: 285 IQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWE--RPTKVRLPKLYLK 342
V + N + + +P E + + L+ D + L E R + LPKL +
Sbjct: 261 SWVLLMKYLGNATAIFFLPD--EGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318
Query: 343 HQMDLVATLSQLGLQELF-QAPDLRGISEQS-LVVSGVQHQSTLELSEVGVEAAAATSIA 400
DL + L QLG+ ++F DL G++E++ L +S H++ L + E G EAA A +
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLE 378
Query: 401 MSRMSL-SSFSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
MS+ N+PF+F + E T PLF+G V NP
Sbjct: 379 AIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNP 415
>gi|50363217 serine proteinase inhibitor, clade A, member 1 [Homo
sapiens]
Length = 418
Score = 137 bits (345), Expect = 2e-32
Identities = 112/397 (28%), Positives = 187/397 (47%), Gaps = 21/397 (5%)
Query: 55 QEPGGQTALKSPPGVCSRD-PTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSV 113
++P G A K+ +D PT +++ + F L+ +A S N+ SP+S+
Sbjct: 25 EDPQGDAAQKTDTSHHDQDHPT---FNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSI 81
Query: 114 ALALSHLALGAQNHTLQR--------LQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAAR 165
A A + L+LG + T L ++ A LL L Q
Sbjct: 82 ATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNG 141
Query: 166 MYLQKGFPIKEDFLEQSEQLFGAKPVSLT-GKQEDDLANINQWVKEATEGKIQEFLSGLP 224
++L +G + + FLE ++L+ ++ ++ G E+ IN +V++ T+GKI + + L
Sbjct: 142 LFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELD 201
Query: 225 EDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPE 284
DTV L+N I F+G W F+ T+ + FH+D+ TV V MM+ R ++
Sbjct: 202 RDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMK-RLGMFNIQHCKKLS 260
Query: 285 IQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWE--RPTKVRLPKLYLK 342
V + N + + +P E + + L+ D + L E R + LPKL +
Sbjct: 261 SWVLLMKYLGNATAIFFLPD--EGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSIT 318
Query: 343 HQMDLVATLSQLGLQELF-QAPDLRGISEQS-LVVSGVQHQSTLELSEVGVEAAAATSIA 400
DL + L QLG+ ++F DL G++E++ L +S H++ L + E G EAA A +
Sbjct: 319 GTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLE 378
Query: 401 MSRMSL-SSFSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
MS+ N+PF+F + E T PLF+G V NP
Sbjct: 379 AIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNP 415
>gi|17998551 serine (or cysteine) proteinase inhibitor, clade B
(ovalbumin), member 12 [Homo sapiens]
Length = 405
Score = 135 bits (341), Expect = 6e-32
Identities = 115/403 (28%), Positives = 185/403 (45%), Gaps = 49/403 (12%)
Query: 82 LARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGS- 140
L A F DLF + + N+ SPLS++ AL + LGA++ + ++ +VLH
Sbjct: 4 LVTANTKFCFDLFQEIGKDDRHKNIFFSPLSLSAALGMVRLGARSDSAHQIDEVLHFNEF 63
Query: 141 --------GPCLP---------------------HLLSRLCQDLGPGAFRLAARMYLQKG 171
PCL LLS+L + +A R+Y ++
Sbjct: 64 SQNESKEPDPCLKSNKQKAGSLNNESGLVSCYFGQLLSKLDRIKTDYTLSIANRLYGEQE 123
Query: 172 FPIKEDFLEQSEQLFGA--KPVSLTGKQEDDLANINQWVKEATEGKIQEFLS--GLPEDT 227
FPI +++L+ Q + + V E IN WV+ ++GKI+E S + +T
Sbjct: 124 FPICQEYLDGVIQFYHTTIESVDFQKNPEKSRQEINFWVECQSQGKIKELFSKDAINAET 183
Query: 228 VLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQV 287
VL+L+NA++F+ W FD T F L+ V+MM + R +E+ + Q+
Sbjct: 184 VLVLVNAVYFKAKWETYFDHENTVDAPFCLNANENKSVKMMTQKGL-YRIGFIEEVKAQI 242
Query: 288 AHFPF-KNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVW-------ERPTKVRLPKL 339
+ K +S VL+P+H + N+ + T + W E + P+
Sbjct: 243 LEMRYTKGKLSMFVLLPSHSKDNLKGLEELERKITYEKMVAWSSSENMSEESVVLSFPRF 302
Query: 340 YLKHQMDLVATLSQLGLQELFQ--APDLRGIS-EQSLVVSGVQHQSTLELSEVGVEAAAA 396
L+ DL + L +G+ ++F DL GIS +L +S + H++ +E+ E G +AAAA
Sbjct: 303 TLEDSYDLNSILQDMGITDIFDETRADLTGISPSPNLYLSKIIHKTFVEVDENGTQAAAA 362
Query: 397 TSIAMSRMSLSS---FSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
T +S SL S F+ N PFLFFI + T LF G V +P
Sbjct: 363 TGAVVSERSLRSWVEFNANHPFLFFIRHNKTQTILFYGRVCSP 405
>gi|28076869 serine (or cysteine) proteinase inhibitor, clade B
(ovalbumin), member 4 [Homo sapiens]
Length = 390
Score = 134 bits (338), Expect = 1e-31
Identities = 106/391 (27%), Positives = 187/391 (47%), Gaps = 40/391 (10%)
Query: 82 LARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLH---- 137
L+ A F DLF ++ N+ SP+S+ AL + LGA+++T Q++ +VLH
Sbjct: 4 LSEANTKFMFDLFQQFRKSKE-NNIFYSPISITSALGMVLLGAKDNTAQQISKVLHFDQV 62
Query: 138 ------------AGSGPCLPHLLSRLCQDLGPGA----FRLAARMYLQKGFPIKEDFLEQ 181
+ H +L + ++A +++ +K + +++L+
Sbjct: 63 TENTTEKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYQFLQEYLDA 122
Query: 182 SEQLF--GAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSG--LPEDTVLLLLNAIHF 237
++ + + E+ IN WV+ T KI+ + DT L+L+NAI+F
Sbjct: 123 IKKFYQTSVESTDFANAPEESRKKINSWVESQTNEKIKNLFPDGTIGNDTTLVLVNAIYF 182
Query: 238 QGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFK-NNM 296
+G W NKF T+ + F ++ V+MM+ + + LLE + +V P+K ++
Sbjct: 183 KGQWENKFKKENTKEEKFWPNKNTYKSVQMMR-QYNSFNFALLEDVQAKVLEIPYKGKDL 241
Query: 297 SFVVLVPTHFE--WNVSQVLAN---LSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATL 351
S +VL+P + + + L + W +L + E + LP+ ++ DL TL
Sbjct: 242 SMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQN--MRETCVDLHLPRFKMEESYDLKDTL 299
Query: 352 SQLGLQELFQA-PDLRGIS-EQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSS- 408
+G+ +F DL G++ L VS V H++ +E++E GVEAAAAT++ + +S S
Sbjct: 300 RTMGMVNIFNGDADLSGMTWSHGLSVSKVLHKAFVEVTEEGVEAAAATAVVVVELSSPST 359
Query: 409 ---FSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
F N PFLFFI ++ T LF G +P
Sbjct: 360 NEEFCCNHPFLFFIRQNKTNSILFYGRFSSP 390
>gi|27777657 serine (or cysteine) proteinase inhibitor, clade A
(alpha-1 antiproteinase, antitrypsin), member 12 [Homo
sapiens]
Length = 414
Score = 134 bits (337), Expect = 2e-31
Identities = 103/372 (27%), Positives = 185/372 (49%), Gaps = 25/372 (6%)
Query: 82 LARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGSG 141
LAR M L +A + N+ LSPLS++ A S L LGAQ+ TL ++Q +
Sbjct: 48 LARQNMDLGFKLLKKLAFYNPGRNIFLSPLSISTAFSMLCLGAQDSTLDEIKQGFNFRKM 107
Query: 142 P---------CLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQSEQLFGAKPVS 192
P + H L++ QDL + +++ + + FLE ++ + A+ +
Sbjct: 108 PEKDLHEGFHYIIHELTQKTQDL---KLSIGNTLFIDQRLQPQRKFLEDAKNFYSAETI- 163
Query: 193 LTGKQEDDLAN--INQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWRNKFDPSLT 250
LT Q ++A IN ++ + T GKI + + TV+LL N I F+ W+++FDP++T
Sbjct: 164 LTNFQNLEMAQKQINDFISQKTHGKINNLIENIDPGTVMLLANYIFFRARWKHEFDPNVT 223
Query: 251 QRDSFHLDEQFTVPVEMM-QARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLVPTHFEWN 309
+ + F L++ +V V MM ++ Y + + ++ + P++ N++ + ++P E
Sbjct: 224 KEEDFFLEKNSSVKVPMMFRSGIYQVGYD--DKLSCTILEIPYQKNITAIFILPD--EGK 279
Query: 310 VSQVLANLSWDTLH--PPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELFQA-PDLR 366
+ + L DT L+ R V +P+L++ DL TLS +G+ ++F+ DL
Sbjct: 280 LKHLEKGLQVDTFSRWKTLLSRRVVDVSVPRLHMTGTFDLKKTLSYIGVSKIFEEHGDLT 339
Query: 367 GIS-EQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLS-SFSVNRPFLFFIFEDTT 424
I+ +SL V H++ L++ E G E AA T M +++P+L I+ +
Sbjct: 340 KIAPHRSLKVGEAVHKAELKMDERGTEGAAGTGAQTLPMETPLVVKIDKPYLLLIYSEKI 399
Query: 425 GLPLFVGSVRNP 436
LF+G + NP
Sbjct: 400 PSVLFLGKIVNP 411
>gi|5902072 serine (or cysteine) proteinase inhibitor, clade B
(ovalbumin), member 3 [Homo sapiens]
Length = 390
Score = 133 bits (335), Expect = 3e-31
Identities = 105/391 (26%), Positives = 193/391 (49%), Gaps = 40/391 (10%)
Query: 82 LARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLHAG-- 139
L+ A F DLF ++ N+ SP+S+ AL + LGA+++T Q++++VLH
Sbjct: 4 LSEANTKFMFDLFQQFRKSKE-NNIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQV 62
Query: 140 ----SGPCLPH--------------LLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQ 181
+G + LL+ + ++A +++ +K + +++L+
Sbjct: 63 TENTTGKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLDA 122
Query: 182 SEQLF--GAKPVSLTGKQEDDLANINQWVKEATEGKIQEFL--SGLPEDTVLLLLNAIHF 237
++ + + V E+ IN WV+ T KI+ + + +T L+L+NAI+F
Sbjct: 123 IKKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYF 182
Query: 238 QGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFK-NNM 296
+G W KF+ T+ + F ++ ++MM+ T + LE + +V P+K ++
Sbjct: 183 KGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYT-SFHFASLEDVQAKVLEIPYKGKDL 241
Query: 297 SFVVLVPTHFE--WNVSQVLAN---LSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATL 351
S +VL+P + + + L + W +L + E + LP+ ++ DL TL
Sbjct: 242 SMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQN--MRETRVDLHLPRFKVEESYDLKDTL 299
Query: 352 SQLGLQELFQA-PDLRGIS-EQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSS- 408
+G+ ++F DL G++ + LV+SGV H++ +E++E G EAAAAT++ S +S
Sbjct: 300 RTMGMVDIFNGDADLSGMTGSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFGSSPTST 359
Query: 409 ---FSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
F N PFLFFI ++ T LF G +P
Sbjct: 360 NEEFHCNHPFLFFIRQNKTNSILFYGRFSSP 390
>gi|4826902 serine (or cysteine) proteinase inhibitor, clade B
(ovalbumin), member 10 [Homo sapiens]
Length = 397
Score = 130 bits (328), Expect = 2e-30
Identities = 107/399 (26%), Positives = 194/399 (48%), Gaps = 49/399 (12%)
Query: 82 LARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGSG 141
LA ++ F +L +A+++ N+ S S++ +L+ + LGA+ T ++ QVL
Sbjct: 4 LATSINQFALELSKKLAESAQGKNIFFSSWSISTSLTIVYLGAKGTTAAQMAQVLQFNRD 63
Query: 142 P---CLPH-----------------------LLSRLCQDLGPGAFRLAARMYLQKGFPIK 175
C P L+S + + + A +Y +K +
Sbjct: 64 QGVKCDPESEKKRKMEFNLSNSEEIHSDFQTLISEILKPNDDYLLKTANAIYGEKTYAFH 123
Query: 176 EDFLEQSEQLFGAKP--VSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTV----- 228
+LE + FGA+P V+ + +IN WV+ TEGKIQ L P+D+V
Sbjct: 124 NKYLEDMKTYFGAEPQPVNFVEASDQIRKDINSWVERQTEGKIQNLL---PDDSVDSTTR 180
Query: 229 LLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVA 288
++L+NA++F+G W ++F T F ++E + PV+MM + L F +E+P+
Sbjct: 181 MILVNALYFKGIWEHQFLVQNTTEKPFRINETTSKPVQMMFMKK-KLHIFHIEKPKAVGL 239
Query: 289 HFPFKN-NMSFVVLVPTHFEWNVSQVLANLSWDTLH----PPLVWERPTKVRLPKLYLKH 343
+K+ ++S ++L+P + Q+ ++++ L+ ++ ++ LPK L+
Sbjct: 240 QLYYKSRDLSLLILLPEDIN-GLEQLEKAITYEKLNEWTSADMMELYEVQLHLPKFKLED 298
Query: 344 QMDLVATLSQLGLQELF--QAPDLRGISE-QSLVVSGVQHQSTLELSEVGVEAAAATSIA 400
DL +TLS +G+ + F D G+S ++L +S V H++ +E++E G EAAA +
Sbjct: 299 SYDLKSTLSSMGMSDAFSQSKADFSGMSSARNLFLSNVFHKAFVEINEQGTEAAAGSGSE 358
Query: 401 MS---RMSLSSFSVNRPFLFFIFEDTTGLPLFVGSVRNP 436
+ R+ F+ N PFLFFI + T LF G + +P
Sbjct: 359 IDIRIRVPSIEFNANHPFLFFIRHNKTNTILFYGRLCSP 397
>gi|5453886 serpin peptidase inhibitor, clade I (pancpin), member 2
[Homo sapiens]
Length = 405
Score = 130 bits (328), Expect = 2e-30
Identities = 114/372 (30%), Positives = 182/372 (48%), Gaps = 30/372 (8%)
Query: 89 FTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVL---HAGSGP--- 142
F DL+ V+ S N+I SPL + L L + LGA+ Q+++Q L +G
Sbjct: 29 FAVDLYQEVS-LSHKDNIIFSPLGITLVLEMVQLGAKGKAQQQIRQTLKQQETSAGEEFF 87
Query: 143 CLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQSEQLFGAKPVSLTGKQEDDLA 202
L S + + F LA +YLQ+GF +KE +L +++ F + + L Q+
Sbjct: 88 VLKSFFSAISEKKQEFTFNLANALYLQEGFTVKEQYLHGNKEFFQSA-IKLVDFQDAKAC 146
Query: 203 N--INQWVKEATEGKIQEFLSG--LPEDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLD 258
I+ WV+ T+GKI++ SG T L+L+NAI+F+G W+ KF TQ +F
Sbjct: 147 AEMISTWVERKTDGKIKDMFSGEEFGPLTRLVLVNAIYFKGDWKQKFRKEDTQLINFTKK 206
Query: 259 EQFTVPVEMMQA--RTYPLRWFLLEQPEIQVAHFPFK-NNMSFVVLVPTHFEWNVSQVLA 315
TV + MM+A RT +F QV +K + S ++++P ++ +V
Sbjct: 207 NGSTVKIPMMKALLRT-KYGYFSESSLNYQVLELSYKGDEFSLIIILPAE-GMDIEEVEK 264
Query: 316 NLSWDTLHPPLVW-----ERPTKVRLPKLYLKHQMDLVATLSQLGLQELFQAP-DLRGIS 369
+ T L W E ++ LP+ ++ ++D L L + E+F DL GI+
Sbjct: 265 LI---TAQQILKWLSEMQEEEVEISLPRFKVEQKVDFKDVLYSLNITEIFSGGCDLSGIT 321
Query: 370 EQSLV-VSGVQHQSTLELSEVGVEAAAATSI---AMSRMSLSSFSVNRPFLFFIFEDTTG 425
+ S V VS V + E++E G EAA +T I + ++ S F N PFLF + + T
Sbjct: 322 DSSEVYVSQVTQKVFFEINEDGSEAATSTGIHIPVIMSLAQSQFIANHPFLFIMKHNPTE 381
Query: 426 LPLFVGSVRNPN 437
LF+G V NP+
Sbjct: 382 SILFMGRVTNPD 393
>gi|38504669 serine (or cysteine) proteinase inhibitor, clade B
(ovalbumin), member 8 isoform a [Homo sapiens]
Length = 374
Score = 129 bits (325), Expect = 5e-30
Identities = 113/379 (29%), Positives = 182/379 (48%), Gaps = 32/379 (8%)
Query: 82 LARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVL----- 136
L A F LF ++ + N+ SP+S++ AL+ + +GA+ T ++ Q L
Sbjct: 4 LCEANGTFAISLFKILGEEDNSRNVFFSPMSISSALAMVFMGAKGSTAAQMSQALCLYKD 63
Query: 137 ---HAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQSEQLFGA--KPV 191
H G LLS + + R A R++ +K DF E ++ + A + +
Sbjct: 64 GDIHRG----FQSLLSEVNRTGTQYLLRTANRLFGEKTCDFLPDFKEYCQKFYQAELEEL 119
Query: 192 SLTGKQEDDLANINQWVKEATEGKIQEFLSGLPED--TVLLLLNAIHFQGFWRNKFDPSL 249
S E+ +IN WV E TEGKI E L D T L+L+NAI+F+G W +FD
Sbjct: 120 SFAEDTEECRKHINDWVAEKTEGKISEVLDAGTVDPLTKLVLVNAIYFKGKWNEQFDRKY 179
Query: 250 TQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPF-KNNMSFVVLVPTHFEW 308
T+ F +E+ M + + + + ++ QV P+ + +S V+L+P
Sbjct: 180 TRGMLFKTNEEKKTVQMMFKEAKFKMGY--ADEVHTQVLELPYVEEELSMVILLPDD-NT 236
Query: 309 NVSQVLANLSWDTLHPPLVWERPTK----VRLPKLYLKHQMDLVATLSQLGLQELFQ--A 362
+++ V L+++ E+ TK V LP+L L+ DL L +LG+ + F
Sbjct: 237 DLAVVEKALTYEKFKAWTNSEKLTKSKVQVFLPRLKLEESYDLEPFLRRLGMIDAFDEAK 296
Query: 363 PDLRGIS-EQSLVVSGVQHQSTLELSEVGVEAAAATSIA----MSRMSLSSFSVNRPFLF 417
D G+S E+++ +S V H+ +E++E G EAAAAT++ SRM F + PFLF
Sbjct: 297 ADFSGMSTEKNVPLSKVAHKCFVEVNEEGTEAAAATAVVRNSRCSRME-PRFCADHPFLF 355
Query: 418 FIFEDTTGLPLFVGSVRNP 436
FI T LF G +P
Sbjct: 356 FIRHHKTNCILFCGRFSSP 374
>gi|38504673 serine (or cysteine) proteinase inhibitor, clade B
(ovalbumin), member 8 isoform a [Homo sapiens]
Length = 374
Score = 129 bits (325), Expect = 5e-30
Identities = 113/379 (29%), Positives = 182/379 (48%), Gaps = 32/379 (8%)
Query: 82 LARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVL----- 136
L A F LF ++ + N+ SP+S++ AL+ + +GA+ T ++ Q L
Sbjct: 4 LCEANGTFAISLFKILGEEDNSRNVFFSPMSISSALAMVFMGAKGSTAAQMSQALCLYKD 63
Query: 137 ---HAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQSEQLFGA--KPV 191
H G LLS + + R A R++ +K DF E ++ + A + +
Sbjct: 64 GDIHRG----FQSLLSEVNRTGTQYLLRTANRLFGEKTCDFLPDFKEYCQKFYQAELEEL 119
Query: 192 SLTGKQEDDLANINQWVKEATEGKIQEFLSGLPED--TVLLLLNAIHFQGFWRNKFDPSL 249
S E+ +IN WV E TEGKI E L D T L+L+NAI+F+G W +FD
Sbjct: 120 SFAEDTEECRKHINDWVAEKTEGKISEVLDAGTVDPLTKLVLVNAIYFKGKWNEQFDRKY 179
Query: 250 TQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPF-KNNMSFVVLVPTHFEW 308
T+ F +E+ M + + + + ++ QV P+ + +S V+L+P
Sbjct: 180 TRGMLFKTNEEKKTVQMMFKEAKFKMGY--ADEVHTQVLELPYVEEELSMVILLPDD-NT 236
Query: 309 NVSQVLANLSWDTLHPPLVWERPTK----VRLPKLYLKHQMDLVATLSQLGLQELFQ--A 362
+++ V L+++ E+ TK V LP+L L+ DL L +LG+ + F
Sbjct: 237 DLAVVEKALTYEKFKAWTNSEKLTKSKVQVFLPRLKLEESYDLEPFLRRLGMIDAFDEAK 296
Query: 363 PDLRGIS-EQSLVVSGVQHQSTLELSEVGVEAAAATSIA----MSRMSLSSFSVNRPFLF 417
D G+S E+++ +S V H+ +E++E G EAAAAT++ SRM F + PFLF
Sbjct: 297 ADFSGMSTEKNVPLSKVAHKCFVEVNEEGTEAAAATAVVRNSRCSRME-PRFCADHPFLF 355
Query: 418 FIFEDTTGLPLFVGSVRNP 436
FI T LF G +P
Sbjct: 356 FIRHHKTNCILFCGRFSSP 374
>gi|170295807 neuroserpin precursor [Homo sapiens]
Length = 410
Score = 127 bits (318), Expect = 3e-29
Identities = 107/375 (28%), Positives = 192/375 (51%), Gaps = 25/375 (6%)
Query: 85 AMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGS---- 140
A+ + ++++ + T N++ SPLS+ALA+ + LGAQ T + ++ + S
Sbjct: 25 AIADLSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLKNG 84
Query: 141 --GPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQSEQLFGAKPVSLTGKQE 198
L + + ++A +++Q GF + E+FL+ ++ F A + Q
Sbjct: 85 EEFSFLKEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAAVNHVDFSQN 144
Query: 199 DDLAN-INQWVKEATEGKIQEFLSGLPED--TVLLLLNAIHFQGFWRNKFDPSLTQRDSF 255
+AN IN+WV+ T +++ +S D T L L+NA++F+G W+++F P T+ SF
Sbjct: 145 VAVANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFRPENTRTFSF 204
Query: 256 HLDEQFTVPVEMM-QARTYPLRWFLLEQPE----IQVAHFPFKNNMSFVVLVPTHFEWNV 310
D++ V + MM Q + F E QV P++ + ++LV + E +
Sbjct: 205 TKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLSRQEVPL 264
Query: 311 SQ----VLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELF-QAPDL 365
+ V A L + + V ++ +V LP+ ++ ++DL L LG+ E+F + +L
Sbjct: 265 ATLEPLVKAQLVEEWANS--VKKQKVEVYLPRFTVEQEIDLKDVLKALGITEIFIKDANL 322
Query: 366 RGISE-QSLVVSGVQHQSTLELSEVGVEAAAATS-IAMSRMSL--SSFSVNRPFLFFIFE 421
G+S+ + + +S H+S LE++E G EAAA + IA+SRM++ V+ PF F I
Sbjct: 323 TGLSDNKEIFLSKAIHKSFLEVNEEGSEAAAVSGMIAISRMAVLYPQVIVDHPFFFLIRN 382
Query: 422 DTTGLPLFVGSVRNP 436
TG LF+G V +P
Sbjct: 383 RRTGTILFMGRVMHP 397
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,775,828
Number of Sequences: 37866
Number of extensions: 1017139
Number of successful extensions: 2832
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 56
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2564
Number of HSP's gapped (non-prelim): 72
length of query: 491
length of database: 18,247,518
effective HSP length: 106
effective length of query: 385
effective length of database: 14,233,722
effective search space: 5479982970
effective search space used: 5479982970
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.