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Search of human proteins with 227497736
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|227497736 T-cell activation kelch repeat protein [Homo
sapiens]
(601 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|227497736 T-cell activation kelch repeat protein [Homo sapiens] 1240 0.0
gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Hom... 332 6e-91
gi|21359972 kelch repeat and BTB (POZ) domain containing 7 [Homo... 243 3e-64
gi|45333883 kelch repeat and BTB (POZ) domain-containing 6 [Homo... 243 4e-64
gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Hom... 224 2e-58
gi|109150407 kelch-like 6 [Homo sapiens] 216 4e-56
gi|40018614 DRE1 protein [Homo sapiens] 215 8e-56
gi|148664248 kelch domain containing 6 [Homo sapiens] 213 4e-55
gi|11056006 kelch-like 12 [Homo sapiens] 197 2e-50
gi|38194229 kelch-like 17 [Homo sapiens] 191 1e-48
gi|40807500 kelch-like 20 [Homo sapiens] 190 4e-48
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 182 8e-46
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 182 8e-46
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 181 1e-45
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 181 1e-45
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 181 2e-45
gi|40255071 kelch-like 23 [Homo sapiens] 179 5e-45
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 177 2e-44
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 177 2e-44
gi|223890235 intracisternal A particle-promoted polypeptide isof... 176 4e-44
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 176 7e-44
gi|166235129 kelch-like 3 [Homo sapiens] 175 1e-43
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 173 4e-43
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 173 4e-43
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 173 5e-43
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 172 6e-43
gi|34101268 kelch-like 8 [Homo sapiens] 172 8e-43
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 171 2e-42
gi|55925608 kelch-like 21 [Homo sapiens] 167 3e-41
gi|8922854 kelch-like 26 [Homo sapiens] 167 3e-41
>gi|227497736 T-cell activation kelch repeat protein [Homo sapiens]
Length = 601
Score = 1240 bits (3209), Expect = 0.0
Identities = 601/601 (100%), Positives = 601/601 (100%)
Query: 1 MAASADLSKSSPTPNGIPSSDPASDAMDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKT 60
MAASADLSKSSPTPNGIPSSDPASDAMDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKT
Sbjct: 1 MAASADLSKSSPTPNGIPSSDPASDAMDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKT 60
Query: 61 FSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANV 120
FSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANV
Sbjct: 61 FSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANV 120
Query: 121 QALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFL 180
QALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFL
Sbjct: 121 QALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFL 180
Query: 181 CVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCI 240
CVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCI
Sbjct: 181 CVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCI 240
Query: 241 RFPLMEDTFIEKIPPQFAQAIAKSCVEKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGK 300
RFPLMEDTFIEKIPPQFAQAIAKSCVEKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGK
Sbjct: 241 RFPLMEDTFIEKIPPQFAQAIAKSCVEKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGK 300
Query: 301 KQTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDF 360
KQTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDF
Sbjct: 301 KQTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDF 360
Query: 361 WMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENC 420
WMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENC
Sbjct: 361 WMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENC 420
Query: 421 WTTVCAMPVAMEFHNAVEYKEKIYVLQGEFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYK 480
WTTVCAMPVAMEFHNAVEYKEKIYVLQGEFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYK
Sbjct: 421 WTTVCAMPVAMEFHNAVEYKEKIYVLQGEFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYK 480
Query: 481 DSIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRA 540
DSIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRA
Sbjct: 481 DSIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRA 540
Query: 541 TQVTVEEHVFRTSRKNSLYQYDDIADQWMKVYETPDRLWDLGRHFECAVAKLYPQCLQKV 600
TQVTVEEHVFRTSRKNSLYQYDDIADQWMKVYETPDRLWDLGRHFECAVAKLYPQCLQKV
Sbjct: 541 TQVTVEEHVFRTSRKNSLYQYDDIADQWMKVYETPDRLWDLGRHFECAVAKLYPQCLQKV 600
Query: 601 L 601
L
Sbjct: 601 L 601
>gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Homo
sapiens]
Length = 623
Score = 332 bits (851), Expect = 6e-91
Identities = 199/594 (33%), Positives = 307/594 (51%), Gaps = 38/594 (6%)
Query: 31 HACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKE 90
+A S+L+QLK Y++ TDIV+ V+ G F CH+ VLA S YFR+MF SGL+ES Q
Sbjct: 13 YAVSLLEQLKLFYEQQLFTDIVLIVE-GTEFPCHKMVLATCSSYFRAMFMSGLSESKQTH 71
Query: 91 VRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQ 150
V + V+A ++ +++ YAYT + + ++ V+ L+ A Q+ + +C +Y+I ++ +
Sbjct: 72 VHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAE 131
Query: 151 NSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDRE 210
N + + FAD + +EL +K + KF V + F+QL+ D LI IL SD+LNV++E
Sbjct: 132 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKE 191
Query: 211 EHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDT---FIEKIPPQFAQAIAKSCVE 267
E V E+ + W E+ R +L + ++ L E T + + +PP + + +
Sbjct: 192 ETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSVVVQGLYK 251
Query: 268 KGPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREV 327
P RLGMT EM+I +A+ ++ + C +V+KLC PP DL +V
Sbjct: 252 SMPKFFK---PRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKV 308
Query: 328 GILVSPDNDIYIAGGYRP---------SSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLR 378
G +V+PDNDIYIAGG P +S++ + N F+ +D N W K +L
Sbjct: 309 GTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLF 368
Query: 379 ARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVE 438
RI LV C G +YAIGG G+ + ++VE YD+ ++ WT V +P A ++ AV
Sbjct: 369 VRIKPSLVCCEGYIYAIGGDSVGGE--LNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVV 426
Query: 439 YKEKIYVLQGEFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAG---TCGNHQR 495
+ IYV+ Y P+ D W + R AA + D I+YI G + R
Sbjct: 427 VHDCIYVMTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIR 486
Query: 496 M---------FTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRATQVTVE 546
+ TVE YD+ N+W + P + +P ++ V+ N L +F+R T +
Sbjct: 487 LPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHL--- 543
Query: 547 EHVFRTSRKNSLYQYDDIADQWMKVYETPDR-LWDLGRHFECAVAKLYPQCLQK 599
K YQYD D+W +R LWDLGR F C V KLYP CL++
Sbjct: 544 ----NERAKYVTYQYDLELDRWSLRQHISERVLWDLGRDFRCTVGKLYPSCLEE 593
>gi|21359972 kelch repeat and BTB (POZ) domain containing 7 [Homo
sapiens]
Length = 684
Score = 243 bits (621), Expect = 3e-64
Identities = 176/622 (28%), Positives = 280/622 (45%), Gaps = 90/622 (14%)
Query: 28 DPFHACSILKQLKTMYDEGQLTDIVVEV-------DHGKTFSCHRNVLAAISPYFRSMFT 80
D H+ ++L QLK+ YD L D+ +EV G+ FSC+RNVLAA PYF+SMFT
Sbjct: 42 DTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFT 101
Query: 81 SGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCA 140
G+ ES Q V + V+AES +++++Y YT RV L+EANVQ L+ A+ + Q+ +++ CA
Sbjct: 102 GGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACA 161
Query: 141 KYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTK-----EQEFLQLTKDQ 195
++ LD N + FAD + H +L +++ YI F +++ E+ LT Q
Sbjct: 162 SFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQ 221
Query: 196 LISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRF------------- 242
L+++L D L+++ E V ++W E ER E+F KC+R+
Sbjct: 222 LLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVF-KCVRWMHFTEEDQDYLEG 280
Query: 243 ----PLME----DTFIEKIPPQFAQAIAKSCVEKGPSNTNGCT------------QRLGM 282
P+++ D + ++ + KS V S+++ + QRLGM
Sbjct: 281 LLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGM 340
Query: 283 TASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREV------GILVSPDND 336
A EM+I F + C D +G ++ + P + VSPD+D
Sbjct: 341 CAKEMVIFF------GHPRDPFLCYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHD 394
Query: 337 IYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIG 396
IY+A R D W+Y + N W L R G + Y G +Y +G
Sbjct: 395 IYLAAQPR-------------KDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILG 441
Query: 397 GRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQGEFFLFYEP 456
GR + LK VECY + N W V +P + + + +Y + + L Y+P
Sbjct: 442 GR--DPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNSKRMLCYDP 499
Query: 457 QKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDFP 516
+ W + Q A V+ D IY I + ++ Y+ +W R + P
Sbjct: 500 SHNMWLNCASLKRSDFQE-ACVFNDEIYCICD-------IPVMKVYNPARGEWRRISNIP 551
Query: 517 CDQSINPYLKLVLFQNKLHLFVRATQVTVEEHVFRTSRKNSLYQYDDIADQWMKVYETPD 576
D + Y ++V KL L T + V ++Y+YD DQW+ + T
Sbjct: 552 LDSETHNY-QIVNHDQKLLLITSTTPQWKKNRV-------TVYEYDTREDQWINI-GTML 602
Query: 577 RLWDLGRHFECAVAKLYPQCLQ 598
L F C A++YP CL+
Sbjct: 603 GLLQFDSGFICLCARVYPSCLE 624
>gi|45333883 kelch repeat and BTB (POZ) domain-containing 6 [Homo
sapiens]
Length = 674
Score = 243 bits (620), Expect = 4e-64
Identities = 174/622 (27%), Positives = 288/622 (46%), Gaps = 90/622 (14%)
Query: 28 DPFHACSILKQLKTMYDEGQLTDIVVEV-------DHGKTFSCHRNVLAAISPYFRSMFT 80
D H+ ++L QLK+ YD L D+ +EV G+ F C+RNVLAA PYF+SMFT
Sbjct: 42 DTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFT 101
Query: 81 SGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCA 140
G+ ES Q V + V+AES +++++Y YT RV L+EANV+ L+ A+ + Q+ +++ CA
Sbjct: 102 GGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACA 161
Query: 141 KYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVT-----KEQEFLQLTKDQ 195
++ LD N + FAD +GH++L +++ YI + F ++ +E+ LT Q
Sbjct: 162 SFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQ 221
Query: 196 LISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRF------------- 242
L+++L D L+V+ E+ V ++W E ER E+F KC+R+
Sbjct: 222 LLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVF-KCVRWMHFTEEDQDYLEG 280
Query: 243 ----PLME----DTFIEKIPPQFAQAIAKSCVEKGPSNTNGCT------------QRLGM 282
P+++ D + ++ + KS V S+++ + QRLGM
Sbjct: 281 LLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGM 340
Query: 283 TASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLRE------VGILVSPDND 336
A EM+I F + C D +G ++K+ P L + + +SPD+D
Sbjct: 341 CAKEMVIFF------GHPRDPFLCCDPYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHD 394
Query: 337 IYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIG 396
IY+A R D W+Y + N W L R G + Y G +Y +G
Sbjct: 395 IYLAAQPR-------------TDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILG 441
Query: 397 GRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQGEFFLFYEP 456
GR + LK VECY+ + N W V +P + + + ++ +Y L + Y+P
Sbjct: 442 GR--DPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYALNSKRMFCYDP 499
Query: 457 QKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDFP 516
+ W + Q A V+ + IY I + ++ Y+ +W + + P
Sbjct: 500 SHNMWLKCVSLKRNDFQE-ACVFNEEIYCICD-------IPVMKVYNPVRAEWRQMNNIP 551
Query: 517 CDQSINPYLKLVLFQNKLHLFVRATQVTVEEHVFRTSRKNSLYQYDDIADQWMKVYETPD 576
N Y +++ KL L T + V ++Y+YD DQW+ + T
Sbjct: 552 LVSETNNY-RIIKHGQKLLLITSRTPQWKKNRV-------TVYEYDIRGDQWINIGTTLG 603
Query: 577 RLWDLGRHFECAVAKLYPQCLQ 598
L +F C A++YP CL+
Sbjct: 604 -LLQFDSNFFCLSARVYPSCLE 624
>gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Homo
sapiens]
Length = 606
Score = 224 bits (571), Expect = 2e-58
Identities = 158/574 (27%), Positives = 259/574 (45%), Gaps = 62/574 (10%)
Query: 39 LKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEA 98
LK + DE + D ++ K+ CHR +L+A SPYFR F S + E+ +KEV + V+
Sbjct: 23 LKDLLDEKKFIDCTLKAGD-KSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDP 81
Query: 99 ESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIF 158
+DL++ Y Y++ + L + NVQ +F AS FQIPS+ C Y+ L P N + +
Sbjct: 82 AILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRL 141
Query: 159 ADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESII 218
L ++E++ +F+ + KE++F+QL+ +LIS++ +D LNV++EE V+E+++
Sbjct: 142 GLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVM 201
Query: 219 RWFEHEQNEREVHLPEIFAKCIRFPLMEDTF---------IEKIPPQFAQAI-------- 261
+W ++ R +L E+F CIRF LM + + I K P + I
Sbjct: 202 KWVRTDKENRVKNLSEVF-DCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFA 260
Query: 262 ------AKSCVEKGPSNTNGCT-------------QRLGMTASEMIICFDAAHKHSGKKQ 302
+K+ + G NG R GM ++I+ +
Sbjct: 261 GKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVN--------DT 312
Query: 303 TVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWM 362
D + R +V+ N IY+ GG E + D ++ F+
Sbjct: 313 AAVAYDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGL--YVDEENKDQPLQSYFFQ 370
Query: 363 YDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWT 422
D + W+ P L AR L K+Y + G+ + + SL SV CYD W
Sbjct: 371 LDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEA--SLDSVLCYDPVAAKWN 428
Query: 423 TVCAMPVAMEFHNAVEYKEKIYVLQGEF--------FLFYEPQKDYWGFLTPMTVPRIQG 474
V +P+ + HN + +K IY L G+ + P+K W L PM +PR
Sbjct: 429 EVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMF 488
Query: 475 LAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKL 534
AV+K I IAG +VEA+D+ NKW +FP ++S + LV L
Sbjct: 489 GVAVHKGKI-VIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERS---SISLVSLAGSL 544
Query: 535 HLFVRATQVTVEEHVFRTSRKNSLYQYDDIADQW 568
+ + +E F + N +++Y+D +W
Sbjct: 545 YAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEW 578
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 216 bits (551), Expect = 4e-56
Identities = 148/482 (30%), Positives = 232/482 (48%), Gaps = 52/482 (10%)
Query: 39 LKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEA 98
L+T+ E LTD+++ VD + FSCHR VLAA S YFR+MF + L E +K + I GV+A
Sbjct: 62 LETLRMENALTDVILCVDI-QEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDA 120
Query: 99 ESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIF 158
E+M +L+Y YTS+ ++T+ NVQ + AA++FQ + D CA ++ L+P+N +G+
Sbjct: 121 ETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRL 180
Query: 159 ADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESII 218
AD + L + + YI + F+ + +EFL L D L IL SDDL V E V+E+++
Sbjct: 181 ADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVM 240
Query: 219 RWFEHEQNEREVHLPEIFAKCIRFPLMED-TFIEKIPPQFAQAIAKSCVEKGP------- 270
W H+ +ER LP + +R PL++ F+E + A + + C E P
Sbjct: 241 SWVRHKPSERLCLLPYVLEN-VRLPLLDPWYFVETVE---ADPLIRQCPEVFPLLQEARM 296
Query: 271 -------SNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPND 323
+ R+ SE+ + K V CLD + ++ K P
Sbjct: 297 YHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLT 356
Query: 324 LREVG---------ILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKP 374
E+ V+ N++YI+GG + ++D W Y+ S N+W+
Sbjct: 357 EHELESENKKWVEFACVTLKNEVYISGG-----------KETQHDVWKYNSSINKWIQIE 405
Query: 375 SLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFH 434
L R K+V GK+Y IGG DG + +VE YD NCW+ + V +
Sbjct: 406 YLNIGRWRHKMVVLGGKVYVIGG----FDGLQRINNVETYDPFHNCWSEAAPLLVHVSSF 461
Query: 435 NAVEYKEKIYVLQG--------EFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYI 486
A +K+K+YV+ G + Y+P + W M V A ++D IY +
Sbjct: 462 AATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVV 521
Query: 487 AG 488
G
Sbjct: 522 GG 523
Score = 36.6 bits (83), Expect = 0.068
Identities = 27/112 (24%), Positives = 43/112 (38%), Gaps = 18/112 (16%)
Query: 331 VSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCG 390
VS + IY+ GG A + Y + W L R C + C
Sbjct: 512 VSFRDRIYVVGG-------------AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNN 558
Query: 391 KMYAIGGRVYEGDGRNS-LKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKE 441
++Y GGR D +N + +V C+D T C +P + H +V ++
Sbjct: 559 RLYITGGR----DEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTIRK 606
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 215 bits (548), Expect = 8e-56
Identities = 151/489 (30%), Positives = 238/489 (48%), Gaps = 59/489 (12%)
Query: 31 HACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKE 90
HA +IL+ D TD+++ V+ GK F CHR VL+A S YFR+MF + ES +
Sbjct: 48 HAENILQIFNEFRDSRLFTDVIICVE-GKEFPCHRAVLSACSSYFRAMFCNDHRESREML 106
Query: 91 VRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQ 150
V I G+ AE+M+ L Y YT +V +T NVQ LF +S+FQI ++D CAK++ LDP
Sbjct: 107 VEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPC 166
Query: 151 NSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDRE 210
N +G+ FAD + + L + K + + F V++ +EFL+L KD+LI + SD+L + +E
Sbjct: 167 NCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKE 226
Query: 211 EHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSCVEKGP 270
E V+E+++RW + R L E+ +R PL+ P F Q + V++
Sbjct: 227 EMVFEAVMRWVYRAVDLRRPLLHELLTH-VRLPLLH-------PNYFVQTVE---VDQLI 275
Query: 271 SNTNGCTQ------RLGMTASEMIICFDAAHKHSGKKQTV-----------------PCL 307
N+ C Q R + +EM+ + +G + + C
Sbjct: 276 QNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECY 335
Query: 308 DIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHST 367
D VTG L K P + + + NDI ++GG S D W+Y+
Sbjct: 336 DPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINS-----------RDVWIYNSQL 384
Query: 368 NRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAM 427
N W+ SL + R K+ GK+Y +GG DG+N L SVECYDS N WT V +
Sbjct: 385 NIWIRVASLNKGRWRHKMAVLLGKVYVVGGY----DGQNRLSSVECYDSFSNRWTEVAPL 440
Query: 428 PVAMEFHNAVEYKEKIYVLQG--------EFFLFYEPQKDYWGFLTPMTVPRIQGLAAVY 479
A+ K++V+ G + Y+P+ + W + + + + + AV
Sbjct: 441 KEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAK-RCITAVS 499
Query: 480 KDSIYYIAG 488
+++ Y+AG
Sbjct: 500 LNNLIYVAG 508
Score = 51.6 bits (122), Expect = 2e-06
Identities = 34/119 (28%), Positives = 53/119 (44%), Gaps = 19/119 (15%)
Query: 331 VSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCG 390
VS +N IY+AGG + + YD + W+ + + C + C G
Sbjct: 498 VSLNNLIYVAGGLTKA-------------IYCYDPVEDYWMHVQNTFSRQENCGMSVCNG 544
Query: 391 KMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAV---EYKEKIYVL 446
K+Y +GGR G+ + ++ CYD + T V AMP + +H V Y EK + L
Sbjct: 545 KIYILGGRRENGEATD---TILCYDPATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL 600
Score = 39.3 bits (90), Expect = 0.010
Identities = 49/215 (22%), Positives = 77/215 (35%), Gaps = 37/215 (17%)
Query: 404 GRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAV-EYKEKIYVLQGEF----FLFYEPQK 458
G +L ECYD W ++ +P + AV + I V G Y Q
Sbjct: 325 GGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRDVWIYNSQL 384
Query: 459 DYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWTR------- 511
+ W + + R + AV +Y + G G + R+ +VE YD N+WT
Sbjct: 385 NIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQN-RLSSVECYDSFSNRWTEVAPLKEA 443
Query: 512 -------------------KKDFPCD---QSINPYLKLVLFQNKLHLFVRA-TQVTVEEH 548
D C QS +P L + + + R T V++
Sbjct: 444 VSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNL 503
Query: 549 VF-RTSRKNSLYQYDDIADQWMKVYETPDRLWDLG 582
++ ++Y YD + D WM V T R + G
Sbjct: 504 IYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQENCG 538
>gi|148664248 kelch domain containing 6 [Homo sapiens]
Length = 623
Score = 213 bits (542), Expect = 4e-55
Identities = 137/491 (27%), Positives = 233/491 (47%), Gaps = 37/491 (7%)
Query: 31 HACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKE 90
H+ ++L +++ M + ++ D+V+ + G+ F CHR VLAA SPYF++MFT GL E Q+E
Sbjct: 13 HSLNLLNKIQNMKELAEMIDVVLTAE-GEKFPCHRLVLAAFSPYFKAMFTCGLLECNQRE 71
Query: 91 VRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQ 150
V + + AES+ ++LNY Y + + + ANVQ + AA Q+ + C KYM+ H+D
Sbjct: 72 VILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYMMDHMDAS 131
Query: 151 NSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDRE 210
N +G++ FA G ++L DRSK+Y+ + F V+ +E L++ Q ++++ SDDLN+ RE
Sbjct: 132 NCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTLIKSDDLNISRE 191
Query: 211 EHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKS-CVE-- 267
E + + ++RW H + R VHL E+ K +R L+ +F+ + + + + CV+
Sbjct: 192 ESILDLVLRWVNHNKELRTVHLVELL-KQVRLELVNPSFLRQALRRNTMLLCDADCVDII 250
Query: 268 -------KGPSNTNGCTQRLGMTASEMIICF-----DAAHKHSGKKQTVPCLDIVTGRVF 315
K P + R GM + +++C +H C D V+ + +
Sbjct: 251 QNAFKAIKTPQQ-HSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDASFCYDPVSRKTY 309
Query: 316 KLCKPP--NDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSK 373
+ P L V V +N+ I G S+S++S + + Y N++ K
Sbjct: 310 FISSPKYGEGLGTVCTGVVMENNTIIVAG-EASASKLSRQKNKNVEIYRYHDRGNQFWEK 368
Query: 374 PSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEF 433
R L +Y IGG++ + V+ Y + W V +P+ +
Sbjct: 369 LCTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLAC 428
Query: 434 HNAVEYKEKIYVLQG----------------EFFLFYEPQKDYWGFLTPMTVPRIQGLAA 477
H V K+YV+ G L Y+P +D W PM + + A
Sbjct: 429 HAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTA 488
Query: 478 VYKDSIYYIAG 488
V IY + G
Sbjct: 489 VVNSEIYVLGG 499
Score = 36.6 bits (83), Expect = 0.068
Identities = 33/125 (26%), Positives = 56/125 (44%), Gaps = 11/125 (8%)
Query: 449 EFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCG-NHQRMFT--VEAYDIE 505
E + +++ +W L + L +++ D +Y I G +Q + T V+ Y +E
Sbjct: 354 EIYRYHDRGNQFWEKLCTAEFRELYALGSIHND-LYVIGGQMKIKNQYLITNCVDKYSVE 412
Query: 506 LNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRAT-QVTV-EEHVFRTSRKNSLYQYDD 563
+ W R P + + +V NKL++ T Q+ + +E R S N L QYD
Sbjct: 413 RDNWKRVSPLPLQLACHA---VVTVNNKLYVIGGWTPQMDLPDEEPDRLS--NKLLQYDP 467
Query: 564 IADQW 568
DQW
Sbjct: 468 SQDQW 472
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 197 bits (501), Expect = 2e-50
Identities = 153/554 (27%), Positives = 244/554 (44%), Gaps = 84/554 (15%)
Query: 25 DAMDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLT 84
D M HA SIL + ++ L D+ + V+ K F HR VLAA S YF +MFTS L+
Sbjct: 9 DIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQ-KDFPAHRIVLAACSDYFCAMFTSELS 67
Query: 85 ESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMI 144
E + V I G+ A +M+++L++ YT V +T NVQ L AA + Q+ ++ C +++
Sbjct: 68 EKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLE 127
Query: 145 SHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDD 204
S LDP N +G+ FA+ + +L ++ + +K F V + +EF+ L++ ++ ++ D+
Sbjct: 128 SQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDE 187
Query: 205 LNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKI----PPQFAQA 260
+ VD EE V+E++I W +H + ERE LP + + +R PL+ +I + P
Sbjct: 188 IQVDSEEPVFEAVINWVKHAKKEREESLPNLL-QYVRMPLLTPRYITDVIDAEPFIRCSL 246
Query: 261 IAKSCVEKGP---------SNTNGCTQRLGMTASEMIIC----------FDAAHKHSGKK 301
+ V++ S G R + A+E+++ D K+ K
Sbjct: 247 QCRDLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKT 306
Query: 302 Q-------------------------------------TVPCLDIVTGR--VFKLCKPPN 322
Q +V CLD V+ P N
Sbjct: 307 QEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMN 366
Query: 323 DLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIG 382
R + + + IY++GG+ S S++ YD + ++W + AR G
Sbjct: 367 VRRGLAGATTLGDMIYVSGGFDGSRRHTSMER--------YDPNIDQWSMLGDMQTAREG 418
Query: 383 CKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEK 442
LV G +Y +GG DG N L SVE YD WT V M +
Sbjct: 419 AGLVVASGVIYCLGGY----DGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDH 474
Query: 443 IYVLQG-------EFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQR 495
IYV+ G Y + D W +T MT PR A V + +Y IAG GN
Sbjct: 475 IYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGN-SL 533
Query: 496 MFTVEAYDIELNKW 509
+ ++E YD ++ W
Sbjct: 534 LSSIECYDPIIDSW 547
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 191 bits (486), Expect = 1e-48
Identities = 134/493 (27%), Positives = 223/493 (45%), Gaps = 39/493 (7%)
Query: 39 LKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEA 98
+ M G L DIV+ V K H+ VLA+ SPYF +MFT+ ++ES Q V + ++
Sbjct: 82 MSRMRQRGLLCDIVLHVA-AKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDP 140
Query: 99 ESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIF 158
+++D ++ +AYT+ +++ E NVQ L AAS+ Q+ ++D C K+++S LDP N +G+ F
Sbjct: 141 QALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGF 200
Query: 159 ADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESII 218
AD + +L + Y+ + F+ V K +EF+ L Q++ ++ SD LNV EE VY +++
Sbjct: 201 ADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVL 260
Query: 219 RWFEHEQNEREVHLPEIFAKCIRFPLMEDTF---------IEKIPPQFAQAIAKSC---- 265
W +H+ + R H+P + KC+R PL+ F + + P + ++
Sbjct: 261 SWVKHDVDARRQHVPRLM-KCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHL 319
Query: 266 --VEKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPND 323
++G T+ R A ++ + D T R +
Sbjct: 320 LPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFA-IHGDCEAYDTRTDRWHVVASMSTR 378
Query: 324 LREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGC 383
VG+ + N +Y GGY +S +++ YD TN W + S+ R
Sbjct: 379 RARVGV-AAVGNRLYAVGGYDGTSDLATVE--------SYDPVTNTWQPEVSMGTRRSCL 429
Query: 384 KLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKI 443
+ G +Y+ GG DG + L S E YD WT+V AM + +
Sbjct: 430 GVAALHGLLYSAGGY----DGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNL 485
Query: 444 YVLQG-------EFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRM 496
Y + G YEPQ + W + M R AV + ++Y G G +
Sbjct: 486 YAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGT-SCL 544
Query: 497 FTVEAYDIELNKW 509
+VE Y + W
Sbjct: 545 NSVERYSPKAGAW 557
Score = 49.3 bits (116), Expect = 1e-05
Identities = 31/115 (26%), Positives = 47/115 (40%), Gaps = 12/115 (10%)
Query: 334 DNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMY 393
D ++Y GGY SS +++ Y+ N W S+L R + G +Y
Sbjct: 482 DGNLYAVGGYDSSSHLATVEK--------YEPQVNVWSPVASMLSRRSSAGVAVLEGALY 533
Query: 394 AIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQG 448
GG DG + L SVE Y + W +V M + H+ V +Y + G
Sbjct: 534 VAGGN----DGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGG 584
Score = 48.5 bits (114), Expect = 2e-05
Identities = 41/157 (26%), Positives = 64/157 (40%), Gaps = 16/157 (10%)
Query: 363 YDHSTNRW--LSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENC 420
YD T+RW ++ S RAR+G V ++YA+GG DG + L +VE YD N
Sbjct: 362 YDTRTDRWHVVASMSTRRARVGVAAV--GNRLYAVGGY----DGTSDLATVESYDPVTNT 415
Query: 421 WTTVCAMPVAMEFHNAVEYKEKIYVLQG-------EFFLFYEPQKDYWGFLTPMTVPRIQ 473
W +M +Y G Y+P W + M+ R
Sbjct: 416 WQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRY 475
Query: 474 GLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWT 510
A ++Y + G + + TVE Y+ ++N W+
Sbjct: 476 VRVATLDGNLYAVGG-YDSSSHLATVEKYEPQVNVWS 511
Score = 39.3 bits (90), Expect = 0.010
Identities = 28/91 (30%), Positives = 39/91 (42%), Gaps = 12/91 (13%)
Query: 337 IYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIG 396
+Y+AGG +S S++ Y W S + R LV G +YA+G
Sbjct: 532 LYVAGGNDGTSCLNSVER--------YSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVG 583
Query: 397 GRVYEGDGRNSLKSVECYDSRENCWTTVCAM 427
G DG +SL S+E Y+ R N W M
Sbjct: 584 GN----DGSSSLNSIEKYNPRTNKWVAASCM 610
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 190 bits (482), Expect = 4e-48
Identities = 149/531 (28%), Positives = 240/531 (45%), Gaps = 85/531 (16%)
Query: 14 PNGIPSSDPASDAMDPF----HACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLA 69
PN +P P M P+ H L+ + + +L D+V+ V K ++ HR +L+
Sbjct: 30 PNKLPEGVPQPARM-PYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYA-HRVILS 87
Query: 70 AISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASI 129
A SPYFR+MFT L ES Q EV I ++ +M+L++++AYTS++ + E NVQ L AA +
Sbjct: 88 ACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACL 147
Query: 130 FQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFL 189
Q+ IQ+ C +++ LDP N +G+ FAD + +EL + ++ + F V + +EF+
Sbjct: 148 LQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFM 207
Query: 190 QLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTF 249
L +QLI I+ SD+LNV EE V+ +++ W ++ ER LP++ +R PL+ F
Sbjct: 208 LLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQH-VRLPLLSPKF 266
Query: 250 IEKIPPQFAQAIAKSCVEKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDI 309
+ +G S+ +I K C D+
Sbjct: 267 L-----------------------------VGTVGSDPLI-----------KSDEECRDL 286
Query: 310 VTGRVFKLCKPPNDLREVGILVSPDNDI------YIAGGYRPSSSEVSIDHKAENDFWMY 363
V L P G P I + GG+ + S++ Y
Sbjct: 287 VDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVER--------Y 338
Query: 364 DHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCW-- 421
D TN W S+ + R G + +YA+GG DG + L SVE YD + N W
Sbjct: 339 DPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGH----DGSSYLNSVERYDPKTNQWSS 394
Query: 422 ----TTVCAMPVAME----FHNAVEYKEKIYVLQGEFFLFYEPQKDYWGFLTPMTVPRIQ 473
T+ C V + F AV ++ + L Y+P+++ W + M+ R+
Sbjct: 395 DVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCL--NIVERYDPKENKWTRVASMSTRRLG 452
Query: 474 GLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKW-------TRKKDFPC 517
AV +Y + G+ G + TVE Y+ + N+W TR+K C
Sbjct: 453 VAVAVLGGFLYAVGGSDGT-SPLNTVERYNPQENRWHTIAPMGTRRKHLGC 502
Score = 63.2 bits (152), Expect = 7e-10
Identities = 42/154 (27%), Positives = 66/154 (42%), Gaps = 12/154 (7%)
Query: 363 YDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWT 422
YD N+W S+ R+G + G +YA+GG DG + L +VE Y+ +EN W
Sbjct: 433 YDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGG----SDGTSPLNTVERYNPQENRWH 488
Query: 423 TVCAMPVAMEFHNAVEYKEKIYVLQGEFFLF-------YEPQKDYWGFLTPMTVPRIQGL 475
T+ M + Y++ IY + G Y P+ + W + MT R
Sbjct: 489 TIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVG 548
Query: 476 AAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKW 509
AV + + G G + T+E +D + N W
Sbjct: 549 LAVVNGQLMAVGGFDGT-TYLKTIEVFDPDANTW 581
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 182 bits (462), Expect = 8e-46
Identities = 148/583 (25%), Positives = 254/583 (43%), Gaps = 88/583 (15%)
Query: 2 AASADLSKSSPTPNGIPSSDPASDAMDPF-----HACSILKQLKTMYDEGQLTDIVVEVD 56
++S S SS T + + +P + D F HA K+++ QL D+++ V
Sbjct: 124 SSSCRTSNSSQTLSSCHTMEPCTS--DEFFQALNHAEQTFKKMENYLRHKQLCDVIL-VA 180
Query: 57 HGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILT 116
+ HR VL+++S YF +MFT+ + E+ Q+E+++ GVE S+ ++ YAYT R+ L
Sbjct: 181 GDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELK 240
Query: 117 EANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIR 176
E N++ L + A + Q+ + + C K+++ L P N +G+ FAD G +L + Y
Sbjct: 241 EDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTM 300
Query: 177 KKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIF 236
+ F+ V + QEF+ L ++ +L SDD+N+ EE + +++ W H+ +R L ++
Sbjct: 301 EHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLL 360
Query: 237 AKCIRFPLMEDTFIEKIPPQFAQAIAKSC-------------VEKGPSNTNGCTQRLGMT 283
A IR PL+ F+ + C E+ P + T+ T
Sbjct: 361 A-YIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKST 419
Query: 284 ASEMIICFDAAHKHSGKKQT-VPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGG 342
+ F S K T + D+ T + + G+ V D+ +Y+ GG
Sbjct: 420 VGTL---FAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVL-DDKLYVVGG 475
Query: 343 ------------YRPSSSEVSI-----DHK---------------AENDFWMYDHSTNRW 370
Y P + S+ H+ +D W Y ++ RW
Sbjct: 476 RDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERW 535
Query: 371 ---------LSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCW 421
++ S R+ +G ++ GK+YA+GGR DG + LKSVEC+D N W
Sbjct: 536 DPQARQWNFVATMSTPRSTVGVAVL--SGKLYAVGGR----DGSSCLKSVECFDPHTNKW 589
Query: 422 TTVCAMPVAMEFHNAVEYKEKIYVLQG-------------EFFLFYEPQKDYWGFLTPMT 468
T M + +Y + G + Y+P+ D W + M+
Sbjct: 590 TLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMS 649
Query: 469 VPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWTR 511
+ R + D +Y + G G + TVEAYD + N+WT+
Sbjct: 650 ISRDAVGVCLLGDKLYAVGGYDG-QAYLNTVEAYDPQTNEWTQ 691
Score = 43.9 bits (102), Expect = 4e-04
Identities = 36/127 (28%), Positives = 61/127 (48%), Gaps = 9/127 (7%)
Query: 302 QTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDI-YIAGGYRPSSSEVSIDHKAENDF 360
++V C D T + + LC + R G+ V+ N + Y GG+ +S ++ + +
Sbjct: 577 KSVECFDPHTNK-WTLCAQMSK-RRGGVGVTTWNGLLYAIGGHDAPASNLT--SRLSDCV 632
Query: 361 WMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENC 420
YD T+ W + S+ +R + K+YA+GG DG+ L +VE YD + N
Sbjct: 633 ERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGY----DGQAYLNTVEAYDPQTNE 688
Query: 421 WTTVCAM 427
WT V +
Sbjct: 689 WTQVAPL 695
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 182 bits (462), Expect = 8e-46
Identities = 148/583 (25%), Positives = 254/583 (43%), Gaps = 88/583 (15%)
Query: 2 AASADLSKSSPTPNGIPSSDPASDAMDPF-----HACSILKQLKTMYDEGQLTDIVVEVD 56
++S S SS T + + +P + D F HA K+++ QL D+++ V
Sbjct: 170 SSSCRTSNSSQTLSSCHTMEPCTS--DEFFQALNHAEQTFKKMENYLRHKQLCDVIL-VA 226
Query: 57 HGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILT 116
+ HR VL+++S YF +MFT+ + E+ Q+E+++ GVE S+ ++ YAYT R+ L
Sbjct: 227 GDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELK 286
Query: 117 EANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIR 176
E N++ L + A + Q+ + + C K+++ L P N +G+ FAD G +L + Y
Sbjct: 287 EDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTM 346
Query: 177 KKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIF 236
+ F+ V + QEF+ L ++ +L SDD+N+ EE + +++ W H+ +R L ++
Sbjct: 347 EHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLL 406
Query: 237 AKCIRFPLMEDTFIEKIPPQFAQAIAKSC-------------VEKGPSNTNGCTQRLGMT 283
A IR PL+ F+ + C E+ P + T+ T
Sbjct: 407 A-YIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKST 465
Query: 284 ASEMIICFDAAHKHSGKKQT-VPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGG 342
+ F S K T + D+ T + + G+ V D+ +Y+ GG
Sbjct: 466 VGTL---FAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVL-DDKLYVVGG 521
Query: 343 ------------YRPSSSEVSI-----DHK---------------AENDFWMYDHSTNRW 370
Y P + S+ H+ +D W Y ++ RW
Sbjct: 522 RDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERW 581
Query: 371 ---------LSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCW 421
++ S R+ +G ++ GK+YA+GGR DG + LKSVEC+D N W
Sbjct: 582 DPQARQWNFVATMSTPRSTVGVAVL--SGKLYAVGGR----DGSSCLKSVECFDPHTNKW 635
Query: 422 TTVCAMPVAMEFHNAVEYKEKIYVLQG-------------EFFLFYEPQKDYWGFLTPMT 468
T M + +Y + G + Y+P+ D W + M+
Sbjct: 636 TLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMS 695
Query: 469 VPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWTR 511
+ R + D +Y + G G + TVEAYD + N+WT+
Sbjct: 696 ISRDAVGVCLLGDKLYAVGGYDG-QAYLNTVEAYDPQTNEWTQ 737
Score = 43.9 bits (102), Expect = 4e-04
Identities = 36/127 (28%), Positives = 61/127 (48%), Gaps = 9/127 (7%)
Query: 302 QTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDI-YIAGGYRPSSSEVSIDHKAENDF 360
++V C D T + + LC + R G+ V+ N + Y GG+ +S ++ + +
Sbjct: 623 KSVECFDPHTNK-WTLCAQMSK-RRGGVGVTTWNGLLYAIGGHDAPASNLT--SRLSDCV 678
Query: 361 WMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENC 420
YD T+ W + S+ +R + K+YA+GG DG+ L +VE YD + N
Sbjct: 679 ERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGY----DGQAYLNTVEAYDPQTNE 734
Query: 421 WTTVCAM 427
WT V +
Sbjct: 735 WTQVAPL 741
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 181 bits (460), Expect = 1e-45
Identities = 150/562 (26%), Positives = 252/562 (44%), Gaps = 99/562 (17%)
Query: 31 HACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKE 90
HA L++++ E QL D+++ H + HR VL+A+S YF +MFT+ + E+ Q+E
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLR-IPAHRLVLSAVSDYFAAMFTNDVLEAKQEE 222
Query: 91 VRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQ 150
VR+ GV+ +++ ++ YAYT + L E +++L AA + Q+ + D C+ ++I L P
Sbjct: 223 VRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPS 282
Query: 151 NSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDRE 210
N +G+ F D G EL + + +Y + F+ V K QEFL L +++ +L SDD+NV E
Sbjct: 283 NCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDE 342
Query: 211 EHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSCVEKGP 270
E ++ ++++W H+ R+ L + + IR PL +PPQ + S + G
Sbjct: 343 ETIFHALMQWVGHDVQNRQGELGMLLS-YIRLPL--------LPPQLLADLETSSMFTGD 393
Query: 271 SNTNGCTQRLGMTASEMIICFD-----AAHKHSGKKQTVPCLDIVTG--------RVFKL 317
Q+L M A + + + + + +K TV L V G + K
Sbjct: 394 LE----CQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKY 449
Query: 318 CKPPNDLREVGIL---------VSPDNDIYIAGG------------YRP----------- 345
N +G + DN +Y+ GG + P
Sbjct: 450 DLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPM 509
Query: 346 ---------SSSEVSIDHKAENDFWMYDHSTNRW---------LSKPSLLRARIGCKLVY 387
++ E + +D W Y ++ RW ++ S R+ +G +V
Sbjct: 510 STHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVG--VVA 567
Query: 388 CCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQ 447
K+YAIGGR DG + LKS+E +D N W+ M Y +YV+
Sbjct: 568 LNNKLYAIGGR----DGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVG 623
Query: 448 G-------------EFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQ 494
G + Y+P+ D W + P++VPR D +Y + G G H
Sbjct: 624 GHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDG-HT 682
Query: 495 RMFTVEAYDIELNKWTRKKDFP 516
+ TVE+YD + N+W K++ P
Sbjct: 683 YLNTVESYDAQRNEW--KEEVP 702
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 181 bits (460), Expect = 1e-45
Identities = 152/568 (26%), Positives = 256/568 (45%), Gaps = 59/568 (10%)
Query: 31 HACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKE 90
H+ +L+ L + +L DI++ V K + H+ VLA++SPYF++MFT L+E E
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHA-HKVVLASVSPYFKAMFTGNLSEKENSE 75
Query: 91 VRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQ 150
V ++ ++ ++ YAYT V +++ V++L AA++ QI + +C ++ S LDP
Sbjct: 76 VEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPG 135
Query: 151 NSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDRE 210
N IG+ FA+ YG ++L + +YI + F V + +EF +LT L I+ +D LNV E
Sbjct: 136 NCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATE 195
Query: 211 EHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKI--------PPQFAQAIA 262
E V+ ++ W +++ ER+ +L ++ +R PL+ F+ ++ + + +
Sbjct: 196 ETVFYALESWIKYDVQERQKYLAQLL-NSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLL 254
Query: 263 KSCVEKGPSNTNGCT-QRLGMT---ASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLC 318
++ + + Q + MT + ++C GK CLD V ++
Sbjct: 255 NEALKYHFMPEHRLSHQTVLMTRPRCAPKVLC-----AVGGKSGLFACLDSV-----EMY 304
Query: 319 KPPND-----------LREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHST 367
P ND E GI V D +Y+ GG + K EN ++ T
Sbjct: 305 FPQNDSWIGLAPLNIPRYEFGICVL-DQKVYVIGGIATNVRPGVTIRKHENSVECWNPDT 363
Query: 368 NRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAM 427
N W S + +R +V G++YA+GG DG++ L+SVE Y + W V M
Sbjct: 364 NTWTSLERMNESRSTLGVVVLAGELYALGGY----DGQSYLQSVEKYIPKIRKWQPVAPM 419
Query: 428 PVAMEFHNAVEYKEKIYVLQG------EFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKD 481
A IY + G Y+P KD W + M RI V
Sbjct: 420 TTTRSCFAAAVLDGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLG 479
Query: 482 SIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRAT 541
I+ + G G + ++E YD N+WT C P + +L+V
Sbjct: 480 FIFVVGGHNG-VSHLSSIERYDPHQNQWT-----VCRPMKEPRTGVGAAVIDNYLYV--- 530
Query: 542 QVTVEEHVFRTSRKNSLYQYDDIADQWM 569
V H +S N++ +YD I+D W+
Sbjct: 531 ---VGGH-SGSSYLNTVQKYDPISDTWL 554
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 181 bits (459), Expect = 2e-45
Identities = 148/555 (26%), Positives = 248/555 (44%), Gaps = 97/555 (17%)
Query: 31 HACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKE 90
HA L++++ E QL D+++ H + HR VL+A+S YF +MFT+ + E+ Q+E
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLR-IPAHRLVLSAVSDYFAAMFTNDVLEAKQEE 222
Query: 91 VRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQ 150
VR+ GV+ +++ ++ YAYT + L E +++L AA + Q+ + D C+ ++I L P
Sbjct: 223 VRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPS 282
Query: 151 NSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDRE 210
N +G+ F D G EL + + +Y + F+ V K QEFL L +++ +L SDD+NV E
Sbjct: 283 NCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDE 342
Query: 211 EHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSCVEKGP 270
E ++ ++++W H+ R+ L + + IR PL +PPQ + S + G
Sbjct: 343 ETIFHALMQWVGHDVQNRQGELGMLLS-YIRLPL--------LPPQLLADLETSSMFTGD 393
Query: 271 SNTNGCTQRLGMTASEMIICFD-----AAHKHSGKKQTVPCLDIVTG--------RVFKL 317
Q+L M A + + + + + +K TV L V G + K
Sbjct: 394 LE----CQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKY 449
Query: 318 CKPPNDLREVGIL---------VSPDNDIYIAGG------------YRP----------- 345
N +G + DN +Y+ GG + P
Sbjct: 450 DLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPM 509
Query: 346 ---------SSSEVSIDHKAENDFWMYDHSTNRW---------LSKPSLLRARIGCKLVY 387
++ E + +D W Y ++ RW ++ S R+ +G +V
Sbjct: 510 STHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVG--VVA 567
Query: 388 CCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQ 447
K+YAIGGR DG + LKS+E +D N W+ M Y +YV+
Sbjct: 568 LNNKLYAIGGR----DGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVG 623
Query: 448 G-------------EFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQ 494
G + Y+P+ D W + P++VPR D +Y + G G H
Sbjct: 624 GHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDG-HT 682
Query: 495 RMFTVEAYDIELNKW 509
+ TVE+YD + N+W
Sbjct: 683 YLNTVESYDAQRNEW 697
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 179 bits (455), Expect = 5e-45
Identities = 148/531 (27%), Positives = 234/531 (44%), Gaps = 81/531 (15%)
Query: 28 DPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTEST 87
D H L +T Y +G TDI ++ G F CHR VLAA S YF++MFT+ + E
Sbjct: 15 DSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKF 74
Query: 88 QKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHL 147
+ ++++ G+ + ++ ++NYAYTS++ +T+ NVQ+L AA + Q S++ C ++++ HL
Sbjct: 75 KNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHL 134
Query: 148 DPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNV 207
D N IG+ FA+ + EL S+ + KF V +++EFL+++ ++ + IL +L+V
Sbjct: 135 DIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNLSV 194
Query: 208 DREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSCVE 267
+EE + E +I+W H+ R +C+ + L+ I+ P A+
Sbjct: 195 WKEEAIIEPVIKWTAHDVENR--------IECL-YNLLSYINIDIDPVYLKTALGLQ--- 242
Query: 268 KGPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREV 327
C S + + HK ++ T
Sbjct: 243 ------RSCLLTENKIRSLIYNALNPMHKEISQRSTAT---------------------- 274
Query: 328 GILVSPDNDIYIAGGYR-PSSSEVSIDHKAENDFWMYDHSTNRWLSK---PSLLRARIGC 383
+YI GGY SEV I +D TN W+ P R G
Sbjct: 275 ---------MYIIGGYYWHPLSEVHI----------WDPLTNVWIQGAEIPDYTRESYG- 314
Query: 384 KLVYCCG-KMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEK 442
V C G +Y GG Y D +L +V Y+S + WT M A +H AV
Sbjct: 315 --VTCLGPNIYVTGG--YRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGC 370
Query: 443 IYVLQG-------EFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQR 495
+Y L G E FY+P K+ W + M A V D IY I G CG
Sbjct: 371 VYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGS 430
Query: 496 MF--TVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRATQVT 544
V++Y+ ++N+W+ P + L V F+NKL+L T +T
Sbjct: 431 CTYDKVQSYNSDINEWSLITSSPHPEY---GLCSVPFENKLYLVGGQTTIT 478
Score = 43.1 bits (100), Expect = 7e-04
Identities = 32/113 (28%), Positives = 44/113 (38%), Gaps = 16/113 (14%)
Query: 326 EVGILVSP-DNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCK 384
E G+ P +N +Y+ GG + YD N W ++ R+ C
Sbjct: 456 EYGLCSVPFENKLYLVGGQTTITE-------------CYDPEQNEWREIAPMMERRMECG 502
Query: 385 LVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAV 437
V G +Y GG Y L+S+E YD N W V +P AM H V
Sbjct: 503 AVIMNGCIYVTGGYSYSKG--TYLQSIEKYDPDLNKWEIVGNLPSAMRSHGCV 553
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 177 bits (449), Expect = 2e-44
Identities = 133/475 (28%), Positives = 210/475 (44%), Gaps = 64/475 (13%)
Query: 47 QLTDIVVEVDH----GKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMD 102
QL D+ ++V + F H+ VLA+ SP F++MFT+GL E + V I G+ + M+
Sbjct: 75 QLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVME 134
Query: 103 LVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHY 162
++ +AYT+ + + E V + A ++QI S+ C+ +++ LDP N+IG+ FA+
Sbjct: 135 RLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQI 194
Query: 163 GHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFE 222
G EL R++EYI F V K++EF L+ QL++++ DDLNV E V+ + I W +
Sbjct: 195 GCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVK 254
Query: 223 HEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSCVEKGPSNTNGCTQRLGM 282
++ +R ++ L+ + P F Q + C + + + C L
Sbjct: 255 YDCEQRRFYVQ---------ALLRAVRCHSLTPNFLQMQLQKC--EILQSDSRCKDYLVK 303
Query: 283 TASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGG 342
E+ + HK + Q +PC GR+ IY AGG
Sbjct: 304 IFEELTL-----HKPT---QVMPCRAPKVGRL----------------------IYTAGG 333
Query: 343 Y-RPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYE 401
Y R S S + Y+ S WL L R G G +YA+GGR
Sbjct: 334 YFRQSLSYLE----------AYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNS 383
Query: 402 GDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQGEFFLF-------Y 454
DG +++CY+ N W+ M V IY + G Y
Sbjct: 384 PDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERY 443
Query: 455 EPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKW 509
EP++D W + PM RI AV +Y + G G + R+ + E Y E N+W
Sbjct: 444 EPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTN-RLNSAECYYPERNEW 497
Score = 59.7 bits (143), Expect = 7e-09
Identities = 56/203 (27%), Positives = 78/203 (38%), Gaps = 26/203 (12%)
Query: 318 CKP---PNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKP 374
C P P + VG++ D IY GG S I H N Y+ + W
Sbjct: 406 CAPMSVPRNRIGVGVI---DGHIYAVGG-----SHGCIHH---NSVERYEPERDEWHLVA 454
Query: 375 SLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFH 434
+L RIG + +YA+GG DG N L S ECY N W + AM
Sbjct: 455 PMLTRRIGVGVAVLNRLLYAVGGF----DGTNRLNSAECYYPERNEWRMITAMNTIRSGA 510
Query: 435 NAVEYKEKIYVLQG-------EFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIA 487
IY G Y+ + + W F+ PM R V++ IY +
Sbjct: 511 GVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLG 570
Query: 488 GTCGNHQRMFTVEAYDIELNKWT 510
G G H + +VE YD + + W+
Sbjct: 571 GYDG-HTFLDSVECYDPDTDTWS 592
Score = 47.8 bits (112), Expect = 3e-05
Identities = 45/156 (28%), Positives = 71/156 (45%), Gaps = 22/156 (14%)
Query: 325 REVGILVSPDNDI-YIAGGYRPSSSEVSID-HKAENDFWMYDHSTNRWLSKPSLLRARIG 382
R +G+ V+ N + Y GG+ ++ S + + E + W R ++ + +R+ G
Sbjct: 459 RRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEW-------RMITAMNTIRSGAG 511
Query: 383 CKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEK 442
+++ C +YA GG DG++ L SVE YD WT V M ++ +
Sbjct: 512 VCVLHNC--IYAAGGY----DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGR 565
Query: 443 IYVL---QGEFFL----FYEPQKDYWGFLTPMTVPR 471
IYVL G FL Y+P D W +T MT R
Sbjct: 566 IYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGR 601
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 177 bits (449), Expect = 2e-44
Identities = 133/475 (28%), Positives = 210/475 (44%), Gaps = 64/475 (13%)
Query: 47 QLTDIVVEVDH----GKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMD 102
QL D+ ++V + F H+ VLA+ SP F++MFT+GL E + V I G+ + M+
Sbjct: 75 QLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVME 134
Query: 103 LVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHY 162
++ +AYT+ + + E V + A ++QI S+ C+ +++ LDP N+IG+ FA+
Sbjct: 135 RLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQI 194
Query: 163 GHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFE 222
G EL R++EYI F V K++EF L+ QL++++ DDLNV E V+ + I W +
Sbjct: 195 GCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVK 254
Query: 223 HEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSCVEKGPSNTNGCTQRLGM 282
++ +R ++ L+ + P F Q + C + + + C L
Sbjct: 255 YDCEQRRFYVQ---------ALLRAVRCHSLTPNFLQMQLQKC--EILQSDSRCKDYLVK 303
Query: 283 TASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGG 342
E+ + HK + Q +PC GR+ IY AGG
Sbjct: 304 IFEELTL-----HKPT---QVMPCRAPKVGRL----------------------IYTAGG 333
Query: 343 Y-RPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYE 401
Y R S S + Y+ S WL L R G G +YA+GGR
Sbjct: 334 YFRQSLSYLE----------AYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNS 383
Query: 402 GDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQGEFFLF-------Y 454
DG +++CY+ N W+ M V IY + G Y
Sbjct: 384 PDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERY 443
Query: 455 EPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKW 509
EP++D W + PM RI AV +Y + G G + R+ + E Y E N+W
Sbjct: 444 EPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTN-RLNSAECYYPERNEW 497
Score = 59.7 bits (143), Expect = 7e-09
Identities = 56/203 (27%), Positives = 78/203 (38%), Gaps = 26/203 (12%)
Query: 318 CKP---PNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKP 374
C P P + VG++ D IY GG S I H N Y+ + W
Sbjct: 406 CAPMSVPRNRIGVGVI---DGHIYAVGG-----SHGCIHH---NSVERYEPERDEWHLVA 454
Query: 375 SLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFH 434
+L RIG + +YA+GG DG N L S ECY N W + AM
Sbjct: 455 PMLTRRIGVGVAVLNRLLYAVGGF----DGTNRLNSAECYYPERNEWRMITAMNTIRSGA 510
Query: 435 NAVEYKEKIYVLQG-------EFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIA 487
IY G Y+ + + W F+ PM R V++ IY +
Sbjct: 511 GVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLG 570
Query: 488 GTCGNHQRMFTVEAYDIELNKWT 510
G G H + +VE YD + + W+
Sbjct: 571 GYDG-HTFLDSVECYDPDTDTWS 592
Score = 47.8 bits (112), Expect = 3e-05
Identities = 45/156 (28%), Positives = 71/156 (45%), Gaps = 22/156 (14%)
Query: 325 REVGILVSPDNDI-YIAGGYRPSSSEVSID-HKAENDFWMYDHSTNRWLSKPSLLRARIG 382
R +G+ V+ N + Y GG+ ++ S + + E + W R ++ + +R+ G
Sbjct: 459 RRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEW-------RMITAMNTIRSGAG 511
Query: 383 CKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEK 442
+++ C +YA GG DG++ L SVE YD WT V M ++ +
Sbjct: 512 VCVLHNC--IYAAGGY----DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGR 565
Query: 443 IYVL---QGEFFL----FYEPQKDYWGFLTPMTVPR 471
IYVL G FL Y+P D W +T MT R
Sbjct: 566 IYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGR 601
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 176 bits (447), Expect = 4e-44
Identities = 162/594 (27%), Positives = 244/594 (41%), Gaps = 102/594 (17%)
Query: 31 HACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKE 90
HA IL Q+ M + D+ ++V ++F HR VLAA SPYF ++FT G+ ES++
Sbjct: 19 HAQLILAQINKMRNGQHFCDVQLQVGQ-ESFKAHRLVLAASSPYFAALFTGGMKESSKDV 77
Query: 91 VRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQ 150
V I+G+EA ++L++ YT V + NVQ L AA + Q+ + C +++ +DP
Sbjct: 78 VPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPL 137
Query: 151 NSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDRE 210
N IG+F F++ +L + S+ YI FL V +EFL LTKDQLI IL S++L+++ E
Sbjct: 138 NCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDE 197
Query: 211 EHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSCVEKGP 270
V+ + ++W + +R H+ E+ IRFPL +PP Q + K
Sbjct: 198 YQVFLAAMQWILKDLGKRRKHVVEVLDP-IRFPL--------LPP---QRLLKYIEGVSD 245
Query: 271 SNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREVGIL 330
N Q L E +C K+ C + T +V +P R+
Sbjct: 246 FNLRVALQTLLKEYCE--VC-------KSPKENKFCSFLQTSKV----RPRKKARKY--- 289
Query: 331 VSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIG-------- 382
+Y GGY D +A + +D + W + SL +AR G
Sbjct: 290 ------LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGG 343
Query: 383 ---------------CKLVY------------------------CCGKMYAIGGRVYEGD 403
C Y C G +YA+GG V
Sbjct: 344 MVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWV---- 399
Query: 404 GRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQG--------EFFLFYE 455
G ++E +D EN W V M V+ + E + IYV+ G F Y+
Sbjct: 400 GAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYD 459
Query: 456 PQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDF 515
P W L PM R A D IY + G + TVE Y E KW
Sbjct: 460 PLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASM 519
Query: 516 P------CDQSINPYLKLVLFQNKLHLFVRATQVTVEEHVFRTSRKNSLYQYDD 563
C ++N L + ++ H F+ T VFR +N ++D
Sbjct: 520 KVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPD--THRYEVFRLKWENMCILFND 571
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 176 bits (445), Expect = 7e-44
Identities = 149/530 (28%), Positives = 224/530 (42%), Gaps = 86/530 (16%)
Query: 31 HACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKE 90
HA IL Q+ M + D+ ++V ++F HR VLAA SPYF ++FT G+ ES++
Sbjct: 19 HAQLILAQINKMRNGQHFCDVQLQVGQ-ESFKAHRLVLAASSPYFAALFTGGMKESSKDV 77
Query: 91 VRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQ 150
V I+G+EA ++L++ YT V + NVQ L AA + Q+ + C +++ +DP
Sbjct: 78 VPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPL 137
Query: 151 NSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDRE 210
N IG+F F++ +L + S+ YI FL V +EFL LTKDQLI IL S++L+++ E
Sbjct: 138 NCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDE 197
Query: 211 EHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSCVEKGP 270
V+ + ++W + +R H+ E+ IRFPL+ PPQ + K
Sbjct: 198 YQVFLAAMQWILKDLGKRRKHVVEVLDP-IRFPLL--------PPQ---RLLKYIEGVSD 245
Query: 271 SNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREVGIL 330
N Q L E +C K+ C + T +V +P R+
Sbjct: 246 FNLRVALQTLLKEYCE--VC-------KSPKENKFCSFLQTSKV----RPRKKARKY--- 289
Query: 331 VSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCG 390
+Y GGY D +A + +D + W + SL +AR G + G
Sbjct: 290 ------LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGG 343
Query: 391 KMYAIGGR----------------------------------------VYEGDGRNSLK- 409
+YAIGG +Y G +
Sbjct: 344 MVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEI 403
Query: 410 --SVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQG--------EFFLFYEPQKD 459
++E +D EN W V M V+ + E + IYV+ G F Y+P
Sbjct: 404 GNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSK 463
Query: 460 YWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKW 509
W L PM R A D IY + G + TVE Y E KW
Sbjct: 464 RWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKW 513
Score = 40.8 bits (94), Expect = 0.004
Identities = 42/157 (26%), Positives = 61/157 (38%), Gaps = 27/157 (17%)
Query: 337 IYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSL--LRARIGCKLVYCCGKMYA 394
IY+ GG E+ F +YD + RW P + RA +G + C +Y+
Sbjct: 439 IYVIGGISNEGIEL-------RSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDC--IYS 489
Query: 395 IGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQGEF---- 450
+GG + +++L +VE Y E W V +M V V +YV G
Sbjct: 490 VGGW---NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHD 546
Query: 451 FL---------FYEPQKDYWGFLTPMTVPRIQGLAAV 478
FL Y P D W + M R +G AV
Sbjct: 547 FLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAV 583
Score = 39.7 bits (91), Expect = 0.008
Identities = 31/108 (28%), Positives = 45/108 (41%), Gaps = 10/108 (9%)
Query: 320 PPNDLREVGILVSPDND-IYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLR 378
PP R + V+ ND IY GG+ + + H E Y +W+ S+
Sbjct: 469 PPMGTRRAYLGVAALNDCIYSVGGWNETQDAL---HTVEK----YSFEEEKWVEVASMKV 521
Query: 379 ARIGCKLVYCCGKMYAIGGRVYEGD--GRNSLKSVECYDSRENCWTTV 424
R G +V G +Y GGR D +L SVE Y+ + WT +
Sbjct: 522 PRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEI 569
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 175 bits (443), Expect = 1e-43
Identities = 137/525 (26%), Positives = 232/525 (44%), Gaps = 56/525 (10%)
Query: 4 SADLSKSSPTPNGIPSSDPASDAMDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSC 63
S LS + G + + ++P H K + + + L D+++ V
Sbjct: 5 SVKLSSQTLIQAGDDEKNQRTITVNPAHMGKAFKVMNELRSKQLLCDVMI-VAEDVEIEA 63
Query: 64 HRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQAL 123
HR VLAA SPYF +MFT ++ES K++ I V+ +++ +++Y YT+ + +TE NVQ L
Sbjct: 64 HRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVL 123
Query: 124 FTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVT 183
AAS+ Q+ ++ C ++ S L P N +G+ FAD + +L ++ Y + F V
Sbjct: 124 LPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVM 183
Query: 184 KEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFP 243
+EFL L+ DQ+ S++ SD L V EE V+E++I W +E+ R H+ ++ + +R P
Sbjct: 184 LGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLM-EHVRLP 242
Query: 244 LMEDTFIEKIPPQFAQAIAKSCVEKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQT 303
L+ ++ Q + + + K N N C L ++ D + T
Sbjct: 243 LLPRDYL-------VQTVEEEALIK---NNNTCKDFLIEAMKYHLLPLDQRLLIKNPR-T 291
Query: 304 VPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMY 363
P + P L +V I+V GG P KA Y
Sbjct: 292 KP-------------RTPVSLPKVMIVV---------GGQAP---------KAIRSVECY 320
Query: 364 DHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTT 423
D +RW L R +V+ G +YA+GG +G +++V+ YD ++ WT+
Sbjct: 321 DFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGG----FNGSLRVRTVDVYDGVKDQWTS 376
Query: 424 VCAMPVAMEFHNAVEYKEKIYVLQG-------EFFLFYEPQKDYWGFLTPMTVPRIQGLA 476
+ +M A + +Y + G Y + + W F+ PM R
Sbjct: 377 IASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGV 436
Query: 477 AVYKDSIYYIAGTCG-NHQRMFTVEAYDIELNKWTRKKDFPCDQS 520
V + +Y + G G + Q + TVE Y+ N+W D +S
Sbjct: 437 GVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRS 481
Score = 50.1 bits (118), Expect = 6e-06
Identities = 42/156 (26%), Positives = 63/156 (40%), Gaps = 19/156 (12%)
Query: 334 DNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMY 393
+ +Y GGY +S + + Y+ +TN W+ + R G + G++Y
Sbjct: 440 EGKLYAVGGYDGASRQCL------STVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLY 493
Query: 394 AIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQGE---- 449
A GG DG KSVE YD N W V M + +YV+ G+
Sbjct: 494 ATGGH----DGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSC 549
Query: 450 ---FFLFYEPQKDYWGFL-TPMTVPR-IQGLAAVYK 480
+Y P D W L T M+ R G+A ++K
Sbjct: 550 NLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHK 585
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 173 bits (439), Expect = 4e-43
Identities = 129/492 (26%), Positives = 223/492 (45%), Gaps = 56/492 (11%)
Query: 27 MDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTES 86
++P+H K + + + L D+ + V S HR VLAA SPYF +MFT ++ES
Sbjct: 38 VNPWHMKKAFKVMNELRSQNLLCDVTI-VAEDMEISAHRVVLAACSPYFHAMFTGEMSES 96
Query: 87 TQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISH 146
K VRI V+ ++ ++++Y YT+ + +TE NVQ L AA + Q+ ++ C +++ S
Sbjct: 97 RAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQ 156
Query: 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLN 206
L P N +G+ FAD + +L +++ Y + F V +EFL L +Q+ S++ SD L
Sbjct: 157 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLT 216
Query: 207 VDREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSCV 266
+ EE V+E++I W H+++ R+ + + + +R PL+ ++ Q + + +
Sbjct: 217 ISSEEKVFEAVIAWVNHDKDVRQEFMARLM-EHVRLPLLPREYL-------VQRVEEEAL 268
Query: 267 EKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLRE 326
K N++ C L +A H + + V R+ + P +L +
Sbjct: 269 VK---NSSACKDYL----------IEAMKYHLLPTEQRILMKSVRTRL----RTPMNLPK 311
Query: 327 VGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLV 386
+ ++V GG P KA YD RW L R +V
Sbjct: 312 LMVVV---------GGQAP---------KAIRSVECYDFKEERWHQVAELPSRRCRAGMV 353
Query: 387 YCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVL 446
Y G ++A+GG +G +++V+ YD ++ WT+V M A +Y +
Sbjct: 354 YMAGLVFAVGG----FNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAV 409
Query: 447 QG-------EFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCG-NHQRMFT 498
G Y + + W + PM R V +Y + G G + Q + T
Sbjct: 410 GGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLST 469
Query: 499 VEAYDIELNKWT 510
VE Y+ N+WT
Sbjct: 470 VECYNATTNEWT 481
Score = 56.2 bits (134), Expect = 8e-08
Identities = 44/182 (24%), Positives = 75/182 (41%), Gaps = 20/182 (10%)
Query: 337 IYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIG 396
+Y GG+ S+ S++ Y+ +N W + R + G +YA+G
Sbjct: 406 LYAVGGFDGSTGLSSVE--------AYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVG 457
Query: 397 GRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQG-------E 449
G Y+G R L +VECY++ N WT + M +Y + G +
Sbjct: 458 G--YDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRK 515
Query: 450 FFLFYEPQKDYWGFLTPMTV-PRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNK 508
Y+P + W + M + R G+ AV + + Y+ G + +VE Y+ +K
Sbjct: 516 SVEVYDPTTNAWRQVADMNMCRRNAGVCAV--NGLLYVVGGDDGSCNLASVEYYNPTTDK 573
Query: 509 WT 510
WT
Sbjct: 574 WT 575
Score = 37.7 bits (86), Expect = 0.031
Identities = 28/98 (28%), Positives = 43/98 (43%), Gaps = 15/98 (15%)
Query: 327 VGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLV 386
VG+L +N +Y GG+ S++ +YD +TN W + R +
Sbjct: 495 VGVL---NNLLYAVGGHDGPLVRKSVE--------VYDPTTNAWRQVADMNMCRRNAGVC 543
Query: 387 YCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTV 424
G +Y +GG DG +L SVE Y+ + WT V
Sbjct: 544 AVNGLLYVVGG----DDGSCNLASVEYYNPTTDKWTVV 577
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 173 bits (439), Expect = 4e-43
Identities = 129/492 (26%), Positives = 223/492 (45%), Gaps = 56/492 (11%)
Query: 27 MDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTES 86
++P+H K + + + L D+ + V S HR VLAA SPYF +MFT ++ES
Sbjct: 34 VNPWHMKKAFKVMNELRSQNLLCDVTI-VAEDMEISAHRVVLAACSPYFHAMFTGEMSES 92
Query: 87 TQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISH 146
K VRI V+ ++ ++++Y YT+ + +TE NVQ L AA + Q+ ++ C +++ S
Sbjct: 93 RAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQ 152
Query: 147 LDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLN 206
L P N +G+ FAD + +L +++ Y + F V +EFL L +Q+ S++ SD L
Sbjct: 153 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLT 212
Query: 207 VDREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSCV 266
+ EE V+E++I W H+++ R+ + + + +R PL+ ++ Q + + +
Sbjct: 213 ISSEEKVFEAVIAWVNHDKDVRQEFMARLM-EHVRLPLLPREYL-------VQRVEEEAL 264
Query: 267 EKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLRE 326
K N++ C L +A H + + V R+ + P +L +
Sbjct: 265 VK---NSSACKDYL----------IEAMKYHLLPTEQRILMKSVRTRL----RTPMNLPK 307
Query: 327 VGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLV 386
+ ++V GG P KA YD RW L R +V
Sbjct: 308 LMVVV---------GGQAP---------KAIRSVECYDFKEERWHQVAELPSRRCRAGMV 349
Query: 387 YCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVL 446
Y G ++A+GG +G +++V+ YD ++ WT+V M A +Y +
Sbjct: 350 YMAGLVFAVGG----FNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAV 405
Query: 447 QG-------EFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCG-NHQRMFT 498
G Y + + W + PM R V +Y + G G + Q + T
Sbjct: 406 GGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLST 465
Query: 499 VEAYDIELNKWT 510
VE Y+ N+WT
Sbjct: 466 VECYNATTNEWT 477
Score = 56.2 bits (134), Expect = 8e-08
Identities = 44/182 (24%), Positives = 75/182 (41%), Gaps = 20/182 (10%)
Query: 337 IYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIG 396
+Y GG+ S+ S++ Y+ +N W + R + G +YA+G
Sbjct: 402 LYAVGGFDGSTGLSSVE--------AYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVG 453
Query: 397 GRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQG-------E 449
G Y+G R L +VECY++ N WT + M +Y + G +
Sbjct: 454 G--YDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRK 511
Query: 450 FFLFYEPQKDYWGFLTPMTV-PRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNK 508
Y+P + W + M + R G+ AV + + Y+ G + +VE Y+ +K
Sbjct: 512 SVEVYDPTTNAWRQVADMNMCRRNAGVCAV--NGLLYVVGGDDGSCNLASVEYYNPTTDK 569
Query: 509 WT 510
WT
Sbjct: 570 WT 571
Score = 37.7 bits (86), Expect = 0.031
Identities = 28/98 (28%), Positives = 43/98 (43%), Gaps = 15/98 (15%)
Query: 327 VGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLV 386
VG+L +N +Y GG+ S++ +YD +TN W + R +
Sbjct: 491 VGVL---NNLLYAVGGHDGPLVRKSVE--------VYDPTTNAWRQVADMNMCRRNAGVC 539
Query: 387 YCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTV 424
G +Y +GG DG +L SVE Y+ + WT V
Sbjct: 540 AVNGLLYVVGG----DDGSCNLASVEYYNPTTDKWTVV 573
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 173 bits (438), Expect = 5e-43
Identities = 151/586 (25%), Positives = 246/586 (41%), Gaps = 82/586 (13%)
Query: 31 HACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKE 90
H +L L T+ TD+ + + F CHR VLAA S YF +MF+ GL ES
Sbjct: 28 HPDCVLAHLNTLRKHCMFTDVTLWAGD-RAFPCHRAVLAASSRYFEAMFSHGLRESRDDT 86
Query: 91 VRIV-GVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDP 149
V + E ++L+L++AY+SR+ + E N ++L A + Q ++D A+++ +L P
Sbjct: 87 VNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFP 146
Query: 150 QNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDR 209
N +G+ + +D + + L + S F V + ++F L+KD L+ ++ SD+L +
Sbjct: 147 SNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETED 206
Query: 210 EEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSCVEKG 269
E V+E+I++W +H+ R+VHLPE+ + +R L+ +++ A +A
Sbjct: 207 ERVVFEAILQWVKHDLEPRKVHLPELL-RSVRLALLPSDCLQEAVSSEALLMA------- 258
Query: 270 PSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPC---------LDIVTGRVF---KL 317
+R + E + C ++ G T PC L I+ G+ F K+
Sbjct: 259 -------DERTKLIMDEALRCKTRILQNDG-VVTSPCARPRKAGHTLLILGGQTFMCDKI 310
Query: 318 CKPPNDLREV---GILVSPDND---------IYIAGGYRPSSSEVSIDHKAENDFWMYDH 365
+ + +E+ L SP + +Y+ GG R S + VS D W+YD
Sbjct: 311 YQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGG-RGSENGVS------KDVWVYDT 363
Query: 366 STNRWLSKPSLLRARIGCKLVYCCGKMYAIGGR-----VYEGDGRNSLKSVECYDSRENC 420
W +L AR G +Y +GG V+ SLK VE YD N
Sbjct: 364 VHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANK 423
Query: 421 WTTVCAMPVAMEFHNAVEYKEKIYVLQGEFF--------LFYEPQKDYWGFLTPMTVPRI 472
W V + + V K K++V G Y+P ++ W P
Sbjct: 424 WMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWR 483
Query: 473 QGLAAVYKDSIYYIAGTCGNHQRMFTVEA---YDIELNKWTRKKDFPCDQSINPYLKLVL 529
AAV I+ + G FT + +D E N+WTR D +
Sbjct: 484 YTAAAVLGSQIFIMGG-----DTEFTAASAYRFDCETNQWTRIGDMTAKRM--------- 529
Query: 530 FQNKLHLFVRATQVTVEEHVFRTSRKNSLYQYDDIADQWMKVYETP 575
H ++ V F T R +L YD +D W + P
Sbjct: 530 ---SCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVP 572
Score = 42.0 bits (97), Expect = 0.002
Identities = 32/158 (20%), Positives = 59/158 (37%), Gaps = 14/158 (8%)
Query: 274 NGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREVGILVSP 333
+G + ++A + F H V C D R + P R V
Sbjct: 432 DGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVL- 490
Query: 334 DNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMY 393
+ I+I GG ++ + + +D TN+W + R+ C + K+Y
Sbjct: 491 GSQIFIMGGDTEFTAASA---------YRFDCETNQWTRIGDMTAKRMSCHALASGNKLY 541
Query: 394 AIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAM 431
+GG G K+++CYD + W + +P ++
Sbjct: 542 VVGGYF----GTQRCKTLDCYDPTSDTWNCITTVPYSL 575
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 172 bits (437), Expect = 6e-43
Identities = 136/536 (25%), Positives = 233/536 (43%), Gaps = 80/536 (14%)
Query: 44 DEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDL 103
D ++ D E ++ S R VL+++S YF +MFT+ + E+ Q+E+++ GVE S+
Sbjct: 153 DRPEVDDGTSEEENESDSSSCRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWS 212
Query: 104 VLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYG 163
++ YAYT R+ L E N++ L + A + Q+ + + C K+++ L P N +G+ FAD G
Sbjct: 213 LIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQG 272
Query: 164 HQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEH 223
+L + Y + F+ V + QEF+ L ++ +L SDD+N+ EE + +++ W H
Sbjct: 273 CTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRH 332
Query: 224 EQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSC-------------VEKGP 270
+ +R L ++ A IR PL+ F+ + C E+ P
Sbjct: 333 DLEQRRKDLSKLLA-YIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRP 391
Query: 271 SNTNGCTQRLGMTASEMIICFDAAHKHSGKKQT-VPCLDIVTGRVFKLCKPPNDLREVGI 329
+ T+ T + F S K T + D+ T + + G+
Sbjct: 392 MLQSPRTKPRKSTVGTL---FAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGV 448
Query: 330 LVSPDNDIYIAGG------------YRPSSSEVSI-----DHK---------------AE 357
V D+ +Y+ GG Y P + S+ H+
Sbjct: 449 AVL-DDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG 507
Query: 358 NDFWMYDHSTNRW---------LSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSL 408
+D W Y ++ RW ++ S R+ +G ++ GK+YA+GGR DG + L
Sbjct: 508 HDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVL--SGKLYAVGGR----DGSSCL 561
Query: 409 KSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQG-------------EFFLFYE 455
KSVEC+D N WT M + +Y + G + Y+
Sbjct: 562 KSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYD 621
Query: 456 PQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWTR 511
P+ D W + M++ R + D +Y + G G + TVEAYD + N+WT+
Sbjct: 622 PKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDG-QAYLNTVEAYDPQTNEWTQ 676
Score = 43.9 bits (102), Expect = 4e-04
Identities = 36/127 (28%), Positives = 61/127 (48%), Gaps = 9/127 (7%)
Query: 302 QTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDI-YIAGGYRPSSSEVSIDHKAENDF 360
++V C D T + + LC + R G+ V+ N + Y GG+ +S ++ + +
Sbjct: 562 KSVECFDPHTNK-WTLCAQMSK-RRGGVGVTTWNGLLYAIGGHDAPASNLT--SRLSDCV 617
Query: 361 WMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENC 420
YD T+ W + S+ +R + K+YA+GG DG+ L +VE YD + N
Sbjct: 618 ERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGY----DGQAYLNTVEAYDPQTNE 673
Query: 421 WTTVCAM 427
WT V +
Sbjct: 674 WTQVAPL 680
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 172 bits (436), Expect = 8e-43
Identities = 137/514 (26%), Positives = 231/514 (44%), Gaps = 52/514 (10%)
Query: 23 ASDAMDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSG 82
A++A FH L Y+ G+L D+ ++V K SCH+ VLA + PYFR+MF S
Sbjct: 46 ANEAWKDFHG-----SLLRFYENGELCDVTLKVG-SKLISCHKLVLACVIPYFRAMFLSE 99
Query: 83 LTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKY 142
+ E+ Q + I + ++++ ++ + Y+SR+ LT NVQ L AA I Q+ + C +Y
Sbjct: 100 MAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEY 159
Query: 143 MISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDS 202
M H P N + V FA+ + +L D + +Y F V + ++F+ ++ L +L S
Sbjct: 160 MKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSS 219
Query: 203 DDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIA 262
DLN++ E+ VY + I+W L E A+ +R PL+ F+ + + + I
Sbjct: 220 SDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQ-VRLPLLPVDFLMGVVAK--EQIV 276
Query: 263 KSCVEKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGR--------- 313
K ++ L + +S + F+ + + + +K T L V GR
Sbjct: 277 KQNLKCRDLLDEARNYHLHL-SSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRS 335
Query: 314 --VFKLCKPP--------NDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMY 363
+ + K + R VG+ +S + +Y GG+ + S++ M+
Sbjct: 336 IECYSINKNSWFFGPEMNSRRRHVGV-ISVEGKVYAVGGHDGNEHLGSME--------MF 386
Query: 364 DHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTT 423
D TN+W+ K S+ R G L G +YAIGG D VE YD + W+T
Sbjct: 387 DPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGL----DDNTCFNDVERYDIESDQWST 442
Query: 424 VCAMPVAMEFHNAVEYKEKIYVLQGEFFLF-------YEPQKDYWGFLTPMTVPRI-QGL 475
V M +V +Y + G + Y+P D W + M R G+
Sbjct: 443 VAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGV 502
Query: 476 AAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKW 509
+ ++ Y+ G ++ + +VE YD NKW
Sbjct: 503 SKLH--GCLYVVGGFDDNSPLSSVERYDPRSNKW 534
Score = 44.7 bits (104), Expect = 2e-04
Identities = 31/131 (23%), Positives = 52/131 (39%), Gaps = 11/131 (8%)
Query: 387 YCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVL 446
+ G ++ +GGR GD +S+ECY +N W M + + K+Y +
Sbjct: 315 HTAGVLFCVGGRGGSGD---PFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAV 371
Query: 447 QGE-------FFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTV 499
G ++P + W M R +G+A Y G ++ V
Sbjct: 372 GGHDGNEHLGSMEMFDPLTNKWMMKASMNTKR-RGIALASLGGPIYAIGGLDDNTCFNDV 430
Query: 500 EAYDIELNKWT 510
E YDIE ++W+
Sbjct: 431 ERYDIESDQWS 441
Score = 41.6 bits (96), Expect = 0.002
Identities = 43/175 (24%), Positives = 62/175 (35%), Gaps = 53/175 (30%)
Query: 335 NDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYA 394
N +Y GG +S S++ YD ++W+ + + R G + G +Y
Sbjct: 460 NHVYAVGGNDGMASLSSVER--------YDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYV 511
Query: 395 IGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQGEFFLFY 454
+GG D + L SVE YD R N W V A
Sbjct: 512 VGGF----DDNSPLSSVERYDPRSNKWDYVAA---------------------------- 539
Query: 455 EPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKW 509
+T PR A I+ + G GN + TVEA+D LN+W
Sbjct: 540 ------------LTTPRGGVGIATVMGKIFAVGGHNGN-AYLNTVEAFDPVLNRW 581
Score = 40.0 bits (92), Expect = 0.006
Identities = 25/88 (28%), Positives = 41/88 (46%), Gaps = 12/88 (13%)
Query: 337 IYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIG 396
+Y+ GG+ +S S++ YD +N+W +L R G + GK++A+G
Sbjct: 509 LYVVGGFDDNSPLSSVER--------YDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVG 560
Query: 397 GRVYEGDGRNSLKSVECYDSRENCWTTV 424
G +G L +VE +D N W V
Sbjct: 561 GH----NGNAYLNTVEAFDPVLNRWELV 584
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 171 bits (432), Expect = 2e-42
Identities = 153/583 (26%), Positives = 251/583 (43%), Gaps = 76/583 (13%)
Query: 31 HACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKE 90
+A S+L L + + TD+++ + +TF CHR VLAA S YF +MF+ GL ES E
Sbjct: 28 YADSVLTHLNLLRQQRLFTDVLLHAGN-RTFPCHRAVLAACSRYFEAMFSGGLKESQDSE 86
Query: 91 VRIVG-VEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDP 149
V + E ++L+L+YAY+SRVI+ E N ++L A + + I+D CA+++ +L P
Sbjct: 87 VNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHP 146
Query: 150 QNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDR 209
N +G+ + +D + +L + S F + K ++FLQL +D ++ +L S++L +
Sbjct: 147 TNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETED 206
Query: 210 EEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPL------MEDTFIEKIPPQFAQAIAK 263
E VYES I W ++ +R +LPE+ + +R L ME+ +E++ + Q +K
Sbjct: 207 ERLVYESAINWISYDLKKRYCYLPELL-QTVRLALLPAIYLMENVAMEELITK--QRKSK 263
Query: 264 SCVEKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVF---KLCKP 320
VE+ Q G+ S +C + ++T L ++ G+ F KL
Sbjct: 264 EIVEEAIRCKLKILQNDGVVTS---LC-------ARPRKTGHALFLLGGQTFMCDKLYLV 313
Query: 321 PNDLREV---GILVSPDND---------IYIAGGYRPSSSEVSIDHKAENDFWMYDHSTN 368
+E+ + SP + +YI GG R S + VS D W+YD
Sbjct: 314 DQKAKEIIPKADIPSPRKEFSACAIGCKVYITGG-RGSENGVS------KDVWVYDTLHE 366
Query: 369 RWLSKPSLLRARIG---CKLVYCCGKMYAIGGRV-----YEGDGRNSLKSVECYDSRENC 420
W +L AR G +L +C +Y +GG SLK VE YD N
Sbjct: 367 EWSKAAPMLVARFGHGSAELKHC---LYVVGGHTAATGCLPASPSVSLKQVEHYDPTINK 423
Query: 421 WTTVCAMPVAMEFHNAVEYKEKIYVLQGEFFLF--------YEPQKDYWGFLTPMTVPRI 472
WT V + + V K K++ G Y+ ++ W P
Sbjct: 424 WTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWR 483
Query: 473 QGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQN 532
AAV + I+ + G + ++ E +WT+ D +
Sbjct: 484 YTAAAVLGNQIFIMGG--DTEFSACSAYKFNSETYQWTKVGDVTAKRM------------ 529
Query: 533 KLHLFVRATQVTVEEHVFRTSRKNSLYQYDDIADQWMKVYETP 575
H ++ V F R +L YD D W + P
Sbjct: 530 SCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTVP 572
Score = 39.3 bits (90), Expect = 0.010
Identities = 34/159 (21%), Positives = 59/159 (37%), Gaps = 18/159 (11%)
Query: 275 GCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGR--VFKLCKPPNDLREVGILVS 332
G + ++A + F K V C D R V C P +L
Sbjct: 433 GVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVL-- 490
Query: 333 PDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKM 392
N I+I GG S+ + + ++ T +W + R+ C V K+
Sbjct: 491 -GNQIFIMGGDTEFSACSA---------YKFNSETYQWTKVGDVTAKRMSCHAVASGNKL 540
Query: 393 YAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAM 431
Y +GG G K+++CYD + W ++ +P ++
Sbjct: 541 YVVGGYF----GIQRCKTLDCYDPTLDVWNSITTVPYSL 575
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 167 bits (422), Expect = 3e-41
Identities = 139/543 (25%), Positives = 231/543 (42%), Gaps = 75/543 (13%)
Query: 28 DPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTEST 87
DP HA S+L+ L + E + D+ +E G+ F HR VLAA SPYFR+MF L ES
Sbjct: 14 DPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESR 73
Query: 88 QKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHL 147
+ VR+ GV + + L+L+++YT RV ++ N + L AA + Q P++++ C ++ L
Sbjct: 74 AERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQL 133
Query: 148 DPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNV 207
D N + + FA+ + L ++ +I + + EQ +L +L+ L D L V
Sbjct: 134 DLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQ-LERLPLARLLRYLRDDGLCV 192
Query: 208 DREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLME----------DTFIEKIPP-- 255
+EE Y+ +RW + R H P++ + +R P + + + + PP
Sbjct: 193 PKEEAAYQLALRWVRADPPRRAAHWPQLL-EAVRLPFVRRFYLLAHVEAEPLVARCPPCL 251
Query: 256 ------QFAQAIAKSCVEKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDI 309
+ QA ++GP G+ +E+++ + + TV C +
Sbjct: 252 RLLREARDFQAARYDRHDRGPCPRMRPRPSTGL--AEILVLVGGCDQDCDELVTVDCYNP 309
Query: 310 VTGRVFKLCKPPNDLREVGILVSPDNDIYIAGG----------YRPSSS-----EVSIDH 354
TG+ L + P+ L +V+ NDIY+ GG +R +SS EV+
Sbjct: 310 QTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPML 369
Query: 355 KAE-----------------NDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGG 397
KA + YDH+T+ W + + C C G++YAIG
Sbjct: 370 KAREYHSSSVLDGLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGS 429
Query: 398 RVYEGDGRNSLKSVECYDSRENCWTTV-CAMPVAMEFHNAVEYKEKIYVLQGEFFL---- 452
G+ ++ ++CYD + W+ V C F K L G +
Sbjct: 430 LA----GKETM-VMQCYDPDTDLWSLVDCGQLPPWSF------APKTATLNGLMYFVRDD 478
Query: 453 -----FYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELN 507
Y P ++ W + M + G AV +Y G + VEAYD E
Sbjct: 479 SAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETR 538
Query: 508 KWT 510
W+
Sbjct: 539 AWS 541
Score = 40.4 bits (93), Expect = 0.005
Identities = 27/85 (31%), Positives = 39/85 (45%), Gaps = 5/85 (5%)
Query: 353 DHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVE 412
D AE D +Y+ + N W PS+ + +G L GK+Y GG Y+ S VE
Sbjct: 477 DDSAEVD--VYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGG--YDNTFELS-DVVE 531
Query: 413 CYDSRENCWTTVCAMPVAMEFHNAV 437
YD W+ V +P +H +V
Sbjct: 532 AYDPETRAWSVVGRLPEPTFWHGSV 556
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 167 bits (422), Expect = 3e-41
Identities = 142/533 (26%), Positives = 242/533 (45%), Gaps = 66/533 (12%)
Query: 29 PFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQ 88
P H+ S+L+ L T+ +GQL D+V+ ++ + F H+ VLAA S YFR+MFT G+ E++Q
Sbjct: 43 PSHSTSLLQGLATLRAQGQLLDVVLTINR-EAFPAHKVVLAACSDYFRAMFTGGMREASQ 101
Query: 89 KEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLD 148
+ + GV A + ++++AY++ V L VQ + AA Q+ + + C +++ + +
Sbjct: 102 DVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMS 161
Query: 149 PQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVD 208
+ + + A + L + + + FL + +E++FL+L ++L+ L S+ L
Sbjct: 162 VETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSC 221
Query: 209 REEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDT-FIEKIPPQFAQAIAKSCVE 267
E ++ + +RW +H+ R + IRFPLM+ + ++ + Q + + +
Sbjct: 222 AEIDLFRAAVRWLQHDP-ARRPRASHVLCH-IRFPLMQSSELVDSV--QTLDIMVEDVL- 276
Query: 268 KGPSNTNGCTQRLGMTASEMIICFDAAHKHSGK---KQTVPCL------------DIVTG 312
C Q L + ++ F S + + VP L V+
Sbjct: 277 --------CRQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSS 328
Query: 313 RVFKLCKPP----NDLREVGILVSP------DNDIYIAGG----YRPSSSEVSIDHKAEN 358
+V++L +P +L E+ + S DN +Y+AGG YR S E ++D
Sbjct: 329 KVYQLPEPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYR--SGEGAVD----- 381
Query: 359 DFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRE 418
+ YD NRWL ++ +RI +L CG +YA GGR G SL SVE Y R
Sbjct: 382 ACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAG----SLASVERYCPRR 437
Query: 419 NCWTTVCAMPVAMEFHNAVEYKEKIYVLQG--------EFFLFYEPQKDYWGFLTPMTVP 470
N W C++ H ++Y+ G + Y+P D W F PM+ P
Sbjct: 438 NEWGYACSLKRRTWGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEP 497
Query: 471 RIQGLAAVYKDSIYYIAGTCGNHQRMF---TVEAYDIELNKWTRKKDFPCDQS 520
R+ IY + G + R F VE Y E ++WT QS
Sbjct: 498 RVLHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQS 550
Score = 46.6 bits (109), Expect = 7e-05
Identities = 31/112 (27%), Positives = 50/112 (44%), Gaps = 7/112 (6%)
Query: 337 IYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIG 396
+YI+GGY S + H YD ++W K + R+ +V G++YA+G
Sbjct: 462 LYISGGYGISVEDKKALH-------CYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALG 514
Query: 397 GRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQG 448
GR+ D + +VE Y + WT+V M + KIY++ G
Sbjct: 515 GRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGG 566
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,884,478
Number of Sequences: 37866
Number of extensions: 997457
Number of successful extensions: 3060
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 65
Number of HSP's that attempted gapping in prelim test: 2158
Number of HSP's gapped (non-prelim): 438
length of query: 601
length of database: 18,247,518
effective HSP length: 108
effective length of query: 493
effective length of database: 14,157,990
effective search space: 6979889070
effective search space used: 6979889070
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.