Search of human proteins with 221316663

Search of human proteins with 221316663

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|221316663 RNA pseudouridylate synthase domain containing 4
isoform a [Homo sapiens]
         (377 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|221316663 RNA pseudouridylate synthase domain containing 4 is...   761   0.0  
gi|221316667 RNA pseudouridylate synthase domain containing 4 is...   682   0.0  
gi|216548145 RNA pseudouridylate synthase domain containing 3 is...   111   9e-25
gi|216548152 RNA pseudouridylate synthase domain containing 3 is...    91   2e-18
gi|23308689 RNA pseudouridylate synthase domain containing 2 [Ho...    76   6e-14
gi|17158025 RNA pseudouridylate synthase domain containing 1 [Ho...    52   7e-07
gi|115387118 hypothetical protein LOC57562 [Homo sapiens]              31   1.6  
gi|197304744 RUN domain containing 3B isoform b [Homo sapiens]         30   4.6  
gi|19923090 RUN domain containing 3B isoform a [Homo sapiens]          30   4.6  
gi|116686122 kinesin family member 4 [Homo sapiens]                    29   6.1  

>gi|221316663 RNA pseudouridylate synthase domain containing 4
           isoform a [Homo sapiens]
          Length = 377

 Score =  761 bits (1964), Expect = 0.0
 Identities = 377/377 (100%), Positives = 377/377 (100%)

Query: 1   MAAPRWSASGPWIRGNGQGCGSLFTLVSKPFCAAAAASTAINAQRLAEKLRAQKREQDTK 60
           MAAPRWSASGPWIRGNGQGCGSLFTLVSKPFCAAAAASTAINAQRLAEKLRAQKREQDTK
Sbjct: 1   MAAPRWSASGPWIRGNGQGCGSLFTLVSKPFCAAAAASTAINAQRLAEKLRAQKREQDTK 60

Query: 61  KEPVSTNAVQRRVQEIVRFTRQLQRVHPNVLAKALTRGILHQDKNLVVINKPYGLPVHGG 120
           KEPVSTNAVQRRVQEIVRFTRQLQRVHPNVLAKALTRGILHQDKNLVVINKPYGLPVHGG
Sbjct: 61  KEPVSTNAVQRRVQEIVRFTRQLQRVHPNVLAKALTRGILHQDKNLVVINKPYGLPVHGG 120

Query: 121 PGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQ 180
           PGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQ
Sbjct: 121 PGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQ 180

Query: 181 VVKKYWAITVHVPMPSAGVVDIPIVEKEAQGQQQHHKMTLSPSYRMDDGKMVKVRRSRNA 240
           VVKKYWAITVHVPMPSAGVVDIPIVEKEAQGQQQHHKMTLSPSYRMDDGKMVKVRRSRNA
Sbjct: 181 VVKKYWAITVHVPMPSAGVVDIPIVEKEAQGQQQHHKMTLSPSYRMDDGKMVKVRRSRNA 240

Query: 241 QVAVTQYQVLSSTLSSALVELQPITGIKHQLRVHLSFGLDCPILGDHKYSDWNRLAPQKL 300
           QVAVTQYQVLSSTLSSALVELQPITGIKHQLRVHLSFGLDCPILGDHKYSDWNRLAPQKL
Sbjct: 241 QVAVTQYQVLSSTLSSALVELQPITGIKHQLRVHLSFGLDCPILGDHKYSDWNRLAPQKL 300

Query: 301 SVGTLKKLGLEQSKARYIPLHLHARQLILPALGSGKEELNLVCKLPRFFVHSLHRLRLEM 360
           SVGTLKKLGLEQSKARYIPLHLHARQLILPALGSGKEELNLVCKLPRFFVHSLHRLRLEM
Sbjct: 301 SVGTLKKLGLEQSKARYIPLHLHARQLILPALGSGKEELNLVCKLPRFFVHSLHRLRLEM 360

Query: 361 PNEDQNENNEAKCLGAQ 377
           PNEDQNENNEAKCLGAQ
Sbjct: 361 PNEDQNENNEAKCLGAQ 377


>gi|221316667 RNA pseudouridylate synthase domain containing 4
           isoform b [Homo sapiens]
          Length = 346

 Score =  682 bits (1759), Expect = 0.0
 Identities = 346/377 (91%), Positives = 346/377 (91%), Gaps = 31/377 (8%)

Query: 1   MAAPRWSASGPWIRGNGQGCGSLFTLVSKPFCAAAAASTAINAQRLAEKLRAQKREQDTK 60
           MAAPRWSASGPWIRGNGQGCGSLFTLVSKPFCAAAAASTAINAQRLAEKLRAQKREQDTK
Sbjct: 1   MAAPRWSASGPWIRGNGQGCGSLFTLVSKPFCAAAAASTAINAQRLAEKLRAQKREQDTK 60

Query: 61  KEPVSTNAVQRRVQEIVRFTRQLQRVHPNVLAKALTRGILHQDKNLVVINKPYGLPVHGG 120
           KEPVSTNAVQRRVQEIVRFTRQLQRVHPNVLAKALTRGILHQDKNLVVINKPYGLPVHGG
Sbjct: 61  KEPVSTNAVQRRVQEIVRFTRQLQRVHPNVLAKALTRGILHQDKNLVVINKPYGLPVHGG 120

Query: 121 PGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQ 180
           PGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQ
Sbjct: 121 PGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQ 180

Query: 181 VVKKYWAITVHVPMPSAGVVDIPIVEKEAQGQQQHHKMTLSPSYRMDDGKMVKVRRSRNA 240
           VVKKYWAITVHVPMPSAGVVDIPIVEKEAQ                              
Sbjct: 181 VVKKYWAITVHVPMPSAGVVDIPIVEKEAQ------------------------------ 210

Query: 241 QVAVTQYQVLSSTLSSALVELQPITGIKHQLRVHLSFGLDCPILGDHKYSDWNRLAPQKL 300
            VAVTQYQVLSSTLSSALVELQPITGIKHQLRVHLSFGLDCPILGDHKYSDWNRLAPQKL
Sbjct: 211 -VAVTQYQVLSSTLSSALVELQPITGIKHQLRVHLSFGLDCPILGDHKYSDWNRLAPQKL 269

Query: 301 SVGTLKKLGLEQSKARYIPLHLHARQLILPALGSGKEELNLVCKLPRFFVHSLHRLRLEM 360
           SVGTLKKLGLEQSKARYIPLHLHARQLILPALGSGKEELNLVCKLPRFFVHSLHRLRLEM
Sbjct: 270 SVGTLKKLGLEQSKARYIPLHLHARQLILPALGSGKEELNLVCKLPRFFVHSLHRLRLEM 329

Query: 361 PNEDQNENNEAKCLGAQ 377
           PNEDQNENNEAKCLGAQ
Sbjct: 330 PNEDQNENNEAKCLGAQ 346


>gi|216548145 RNA pseudouridylate synthase domain containing 3
           isoform 1 [Homo sapiens]
          Length = 351

 Score =  111 bits (278), Expect = 9e-25
 Identities = 84/289 (29%), Positives = 142/289 (49%), Gaps = 32/289 (11%)

Query: 91  LAKALTRGILHQDKNLVVINKPYGLPVHGGPGVQLCITDVLPILAKMLHGHKAEPLHLCH 150
           L  AL   ++ +   LV +NKP GLPV G PG +L +  VLP L++ L G + + L +  
Sbjct: 75  LVDALRAAVVDRKGPLVTLNKPQGLPVTGKPG-ELTLFSVLPELSQSL-GLREQELQVVR 132

Query: 151 RLDKETTGVMVLAWDKDMAHQVQELF----RTRQVVKKYWAITVHVPMPSAGVVDIPIVE 206
              KE++G+++L+     A ++Q+ F    R ++    Y A+T  +P  S G +   +  
Sbjct: 133 ASGKESSGLVLLSSCPQTASRLQKYFTHARRAQRPTATYCAVTDGIPAASEGKIQAALKL 192

Query: 207 KEAQGQQQHHKMTLSPSYRMDDGKMVKVRRSRNAQVAVTQYQVLSSTLSSALVELQPITG 266
           +   G      + L+   +    K +        +  ++ ++V+++    ALV+LQP+T 
Sbjct: 193 EHIDG------VNLTVPVKAPSRKDIL----EGVKKTLSHFRVVATGSGCALVQLQPLTV 242

Query: 267 IKHQLRVHLSFGLDCPILGDHKYS---------------DWNRLAPQKLSVGTLKKLGLE 311
              QL+VH+   L CP+LGDH YS               + N+   Q L    L++L L 
Sbjct: 243 FSSQLQVHMVLQL-CPVLGDHMYSARVGTVLGQRFLLPAENNKPQRQVLDEALLRRLHLT 301

Query: 312 QSKARYIPLHLHARQLILPALGSGKEELNLVCKLPRFFVHSLHRLRLEM 360
            S+A  +PLHLH  +L+LP   +    + L+  LP +F  +L  L L +
Sbjct: 302 PSQAAQLPLHLHLHRLLLPGTRARDTPVELLAPLPPYFSRTLQCLGLRL 350


>gi|216548152 RNA pseudouridylate synthase domain containing 3
           isoform 2 [Homo sapiens]
          Length = 336

 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 72/261 (27%), Positives = 126/261 (48%), Gaps = 32/261 (12%)

Query: 119 GGPGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELF-- 176
           G PG +L +  VLP L++ L G + + L +     KE++G+++L+     A ++Q+ F  
Sbjct: 88  GKPG-ELTLFSVLPELSQSL-GLREQELQVVRASGKESSGLVLLSSCPQTASRLQKYFTH 145

Query: 177 --RTRQVVKKYWAITVHVPMPSAGVVDIPIVEKEAQGQQQHHKMTLSPSYRMDDGKMVKV 234
             R ++    Y A+T  +P  S G +   +  +   G      + L+   +    K +  
Sbjct: 146 ARRAQRPTATYCAVTDGIPAASEGKIQAALKLEHIDG------VNLTVPVKAPSRKDIL- 198

Query: 235 RRSRNAQVAVTQYQVLSSTLSSALVELQPITGIKHQLRVHLSFGLDCPILGDHKYS---- 290
                 +  ++ ++V+++    ALV+LQP+T    QL+VH+   L CP+LGDH YS    
Sbjct: 199 ---EGVKKTLSHFRVVATGSGCALVQLQPLTVFSSQLQVHMVLQL-CPVLGDHMYSARVG 254

Query: 291 -----------DWNRLAPQKLSVGTLKKLGLEQSKARYIPLHLHARQLILPALGSGKEEL 339
                      + N+   Q L    L++L L  S+A  +PLHLH  +L+LP   +    +
Sbjct: 255 TVLGQRFLLPAENNKPQRQVLDEALLRRLHLTPSQAAQLPLHLHLHRLLLPGTRARDTPV 314

Query: 340 NLVCKLPRFFVHSLHRLRLEM 360
            L+  LP +F  +L  L L +
Sbjct: 315 ELLAPLPPYFSRTLQCLGLRL 335


>gi|23308689 RNA pseudouridylate synthase domain containing 2 [Homo
           sapiens]
          Length = 545

 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 73/256 (28%), Positives = 121/256 (47%), Gaps = 35/256 (13%)

Query: 38  STAINAQRLA---EKLRAQKREQDTKKEPVSTNAVQRRVQEIVRFTRQLQRVHPNVLAKA 94
           ST   AQ LA     +RA + + + K  PV    +  +  + +R T  + R  P V A+ 
Sbjct: 167 STEFRAQPLAYYEAAVRAGRLQLNEK--PVQDLNIVLKDNDFLRNT--VHRHEPPVTAEP 222

Query: 95  LTRGILHQDKNLVVINKPYGLPVHGGPGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDK 154
           +   +L +++++VV++KP  +PVH  P  +     V+ IL K    H+ + LH  HRLD+
Sbjct: 223 IR--LLAENEDVVVVDKPSSIPVH--PCGRFRHNTVIFILGKE---HQLKELHPLHRLDR 275

Query: 155 ETTGVMVLAWDKDMAHQVQELFRTRQVVKKYWAITVHVPMPSAGVVDIPIVEKEAQGQQQ 214
            T+GV++ A    ++ ++ E  R RQ+ K+Y                        +G+  
Sbjct: 276 LTSGVLMFAKTAAVSERIHEQVRDRQLEKEYVC--------------------RVEGEFP 315

Query: 215 HHKMTLSPSYRMDDGKMVKVRRSRNAQVAVTQYQVLSSTLSSALVELQPITGIKHQLRVH 274
             ++T      +   K+   R     +   T +Q LS    S++V  +P+TG  HQ+RVH
Sbjct: 316 TEEVTCKEPILVVSYKVGVCRVDPRGKPCETVFQRLSYNGQSSVVRCRPLTGRTHQIRVH 375

Query: 275 LSFGLDCPILGDHKYS 290
           L F L  PIL D  Y+
Sbjct: 376 LQF-LGHPILNDPIYN 390


>gi|17158025 RNA pseudouridylate synthase domain containing 1 [Homo
           sapiens]
          Length = 312

 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 43/147 (29%), Positives = 66/147 (44%), Gaps = 18/147 (12%)

Query: 149 CHRLDKETTGVMVLAWDKDMAHQVQELFRTRQVVKKYWAITVHVPMPSAGVVDIPIVEKE 208
           CH+LD  T+G + +A +K  A      F+ R+V K Y A+       S   +   I    
Sbjct: 63  CHQLDFSTSGALCVALNKAAAGSAYRCFKERRVTKAYLALLRGHIQESRVTISHAIGRNS 122

Query: 209 AQGQQQHHKMTLSPSYRMDDGKMVKVRRSRNAQVAVTQYQVLSSTLSS----ALVELQPI 264
            +G+   H M +  S           +   N + ++T   VL   L +    + V L+P+
Sbjct: 123 TEGRA--HTMCIEGS-----------QGCENPKPSLTDLVVLEHGLYAGDPVSKVLLKPL 169

Query: 265 TGIKHQLRVHLSFGLDCPILGDHKYSD 291
           TG  HQLRVH S  L  P++GD  Y +
Sbjct: 170 TGRTHQLRVHCS-ALGHPVVGDLTYGE 195


>gi|115387118 hypothetical protein LOC57562 [Homo sapiens]
          Length = 1117

 Score = 31.2 bits (69), Expect = 1.6
 Identities = 14/62 (22%), Positives = 28/62 (45%)

Query: 26  LVSKPFCAAAAASTAINAQRLAEKLRAQKREQDTKKEPVSTNAVQRRVQEIVRFTRQLQR 85
           L  +  C   A    + + R  +    +++EQ+ K+  +    +Q+R Q+    T + QR
Sbjct: 61  LQQQKICRNRARKYFVESNRRKKAFEEKRKEQEEKEHQIREQILQQRKQKFEEVTEKFQR 120

Query: 86  VH 87
            H
Sbjct: 121 AH 122


>gi|197304744 RUN domain containing 3B isoform b [Homo sapiens]
          Length = 456

 Score = 29.6 bits (65), Expect = 4.6
 Identities = 23/101 (22%), Positives = 43/101 (42%), Gaps = 8/101 (7%)

Query: 142 KAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQVVKKYWAITVHVP--MPSAGV 199
           + E   L H+L+KE    +++     +        R+RQ       +T H+    PS G 
Sbjct: 293 RIEDSDLAHKLEKEQLEYIIVELQDQLTVLKNNDLRSRQ------ELTAHLTNQWPSPGA 346

Query: 200 VDIPIVEKEAQGQQQHHKMTLSPSYRMDDGKMVKVRRSRNA 240
           +D+  V  +    ++H+K     SY+  D    +V  S+ +
Sbjct: 347 LDVNAVALDTLLYRKHNKQWYEKSYQSLDQLSAEVSLSQTS 387


>gi|19923090 RUN domain containing 3B isoform a [Homo sapiens]
          Length = 473

 Score = 29.6 bits (65), Expect = 4.6
 Identities = 23/101 (22%), Positives = 43/101 (42%), Gaps = 8/101 (7%)

Query: 142 KAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQVVKKYWAITVHVP--MPSAGV 199
           + E   L H+L+KE    +++     +        R+RQ       +T H+    PS G 
Sbjct: 310 RIEDSDLAHKLEKEQLEYIIVELQDQLTVLKNNDLRSRQ------ELTAHLTNQWPSPGA 363

Query: 200 VDIPIVEKEAQGQQQHHKMTLSPSYRMDDGKMVKVRRSRNA 240
           +D+  V  +    ++H+K     SY+  D    +V  S+ +
Sbjct: 364 LDVNAVALDTLLYRKHNKQWYEKSYQSLDQLSAEVSLSQTS 404


>gi|116686122 kinesin family member 4 [Homo sapiens]
          Length = 1232

 Score = 29.3 bits (64), Expect = 6.1
 Identities = 55/254 (21%), Positives = 101/254 (39%), Gaps = 40/254 (15%)

Query: 32  CAAAAAST---AINAQRLAEKLRAQKREQDTKKEPVSTNAVQRRVQEIVRFTRQLQRVHP 88
           C + A S     +N  R A++ R  K +     +P  T  +    Q++ +    L + H 
Sbjct: 312 CVSPADSNLEETLNTLRYADRARKIKNKPIVNIDP-QTAELNHLKQQVQQLQVLLLQAHG 370

Query: 89  NVLAKALT-------RGILHQDKNLVVINKPY--GLPVHGGPGVQLCITDVLPILAKMLH 139
             L  ++T       + ++ ++++LV  N+    GL    G   Q+    +L   A    
Sbjct: 371 GTLPGSITVEPSENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKM 430

Query: 140 GHKAEPL--HLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQVVKKYWAITVHVPMPSA 197
             K E L  H   +LD +   ++    D+++   V+ +   +Q++ +    TV      A
Sbjct: 431 NAKLEELRQHAACKLDLQK--LVETLEDQELKENVEIICNLQQLITQLSDETVAC---MA 485

Query: 198 GVVDIPIVEKEAQGQQQHHKMTLSPSYRMDDGKMVKVRRSRNAQVAVTQYQVLSSTLSSA 257
             +D   VE+EAQ       +  SP              SR++    TQ+ +  + +S  
Sbjct: 486 AAIDTA-VEQEAQ-------VETSPE------------TSRSSDAFTTQHALRQAQMSKE 525

Query: 258 LVELQPITGIKHQL 271
           LVEL     +K  L
Sbjct: 526 LVELNKALALKEAL 539


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.134    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,551,828
Number of Sequences: 37866
Number of extensions: 642306
Number of successful extensions: 1425
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 1409
Number of HSP's gapped (non-prelim): 11
length of query: 377
length of database: 18,247,518
effective HSP length: 104
effective length of query: 273
effective length of database: 14,309,454
effective search space: 3906480942
effective search space used: 3906480942
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.