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Search of human proteins with 21362105
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
(589 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 1204 0.0
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 929 0.0
gi|40807500 kelch-like 20 [Homo sapiens] 286 5e-77
gi|40018614 DRE1 protein [Homo sapiens] 280 3e-75
gi|194097389 kelch-like 38 [Homo sapiens] 267 2e-71
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 267 2e-71
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 267 2e-71
gi|166235129 kelch-like 3 [Homo sapiens] 267 2e-71
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 259 6e-69
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 259 6e-69
gi|40255071 kelch-like 23 [Homo sapiens] 258 1e-68
gi|11056006 kelch-like 12 [Homo sapiens] 258 1e-68
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 248 9e-66
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 248 9e-66
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 246 6e-65
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 245 9e-65
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 245 9e-65
gi|38194229 kelch-like 17 [Homo sapiens] 244 1e-64
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 244 2e-64
gi|109150407 kelch-like 6 [Homo sapiens] 242 6e-64
gi|128485503 kelch-like 30 [Homo sapiens] 242 8e-64
gi|55925608 kelch-like 21 [Homo sapiens] 239 4e-63
gi|55925604 kelch-like 18 [Homo sapiens] 237 3e-62
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 233 3e-61
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 233 3e-61
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 225 1e-58
gi|14780904 kelch-like 1 protein [Homo sapiens] 224 1e-58
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 222 9e-58
gi|148664209 kelch-like 10 [Homo sapiens] 214 2e-55
gi|223890235 intracisternal A particle-promoted polypeptide isof... 213 3e-55
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 1204 bits (3116), Expect = 0.0
Identities = 589/589 (100%), Positives = 589/589 (100%)
Query: 1 MSVSVHETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCH 60
MSVSVHETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCH
Sbjct: 1 MSVSVHETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCH 60
Query: 61 RAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESL 120
RAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESL
Sbjct: 61 RAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESL 120
Query: 121 LEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVR 180
LEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVR
Sbjct: 121 LEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVR 180
Query: 181 QSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLAL 240
QSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLAL
Sbjct: 181 QSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLAL 240
Query: 241 LPSDCLQEAVSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAGHTLLIL 300
LPSDCLQEAVSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAGHTLLIL
Sbjct: 241 LPSDCLQEAVSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAGHTLLIL 300
Query: 301 GGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWV 360
GGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWV
Sbjct: 301 GGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWV 360
Query: 361 YDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPG 420
YDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPG
Sbjct: 361 YDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPG 420
Query: 421 ANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQ 480
ANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQ
Sbjct: 421 ANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQ 480
Query: 481 PWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKL 540
PWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKL
Sbjct: 481 PWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKL 540
Query: 541 YVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVSTWKHLPA 589
YVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVSTWKHLPA
Sbjct: 541 YVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVSTWKHLPA 589
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 929 bits (2400), Expect = 0.0
Identities = 440/589 (74%), Positives = 512/589 (86%)
Query: 1 MSVSVHETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCH 60
MSVSVHE RKSR+S+GS+N+ LFHK+S+ D VL HLN LR+ +FTDV L AG+R FPCH
Sbjct: 1 MSVSVHENRKSRASSGSINIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCH 60
Query: 61 RAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESL 120
RAVLAA SRYFEAMFS GL+ES+D VNF +++HPEVLELLLD+AYSSR+ INEENAESL
Sbjct: 61 RAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESL 120
Query: 121 LEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVR 180
LEAGDML+F D+RDA AEFLEKNL P+NCLGM+LLSDAHQC +LYE SWRMCL +F+T+R
Sbjct: 121 LEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIR 180
Query: 181 QSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLAL 240
++EDF L +D ++ L+SS+ELETEDER+V+E+ + W+ +DL+ R +LPELL++VRLAL
Sbjct: 181 KNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLAL 240
Query: 241 LPSDCLQEAVSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAGHTLLIL 300
LP+ L E V+ E L+ ++K I++EA+RCK +ILQNDGVVTS CARPRK GH L +L
Sbjct: 241 LPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLL 300
Query: 301 GGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWV 360
GGQTFMCDK+Y VD KAKEIIPKAD+PSPRKEFSA AIGCKVY+TGGRGSENGVSKDVWV
Sbjct: 301 GGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWV 360
Query: 361 YDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPG 420
YDT+HEEWSKAAPML+ARFGHGSAEL++CLYVVGGHT+ G PASPSVSLKQVE YDP
Sbjct: 361 YDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPT 420
Query: 421 ANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQ 480
NKW MVAPLR+GVSNAAVVSAKLKLF FGGTS+ D + KVQCYD ENRWT+ A CPQ
Sbjct: 421 INKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQ 480
Query: 481 PWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKL 540
PWRYTAAAVLG+QIFIMGGDTEF+A SAY+F+ ET QWT++GD+TAKRMSCHA+ASGNKL
Sbjct: 481 PWRYTAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKL 540
Query: 541 YVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVSTWKHLPA 589
YVVGGYFG QRCKTLDCYDPT D WN ITTVPYSLIPTAFVSTWKHLP+
Sbjct: 541 YVVGGYFGIQRCKTLDCYDPTLDVWNSITTVPYSLIPTAFVSTWKHLPS 589
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 286 bits (731), Expect = 5e-77
Identities = 188/547 (34%), Positives = 277/547 (50%), Gaps = 24/547 (4%)
Query: 28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTV 87
HP L +N LRKH DV L G + HR +L+A S YF AMF+ L ESR V
Sbjct: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 109
Query: 88 NFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPS 147
+D + +ELL+DFAY+S+I + E N ++LL A +LQ ++++A EFL++ L PS
Sbjct: 110 VIRD-IDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPS 168
Query: 148 NCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDE 207
NCLG+ +D H CR L + + +F+ V +SE+F L + L+D+ISSDEL E
Sbjct: 169 NCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSE 228
Query: 208 RVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMD 267
VF A++ WVK+ ++ R+ LP++L+ VRL LL L V S+ L+ +DE + ++D
Sbjct: 229 EQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVD 288
Query: 268 EALRCKTRIL--QNDGVVTSPCARPRK---AGHTLLILGG--QTFMCDKIYQVDHKAKEI 320
EA K +L Q ++ P RPRK G L +GG + + D + E
Sbjct: 289 EA---KNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEW 345
Query: 321 IPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSK-AAPMLIARF 379
A + R S + +Y GG + ++ V YD +WS AP R
Sbjct: 346 RMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLN-SVERYDPKTNQWSSDVAPTSTCRT 404
Query: 380 GHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAV 439
G A L LY VGG ++ L VE+YDP NKW VA + AV
Sbjct: 405 SVGVAVLGGFLYAVGGQDGVS---------CLNIVERYDPKENKWTRVASMSTRRLGVAV 455
Query: 440 VSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG 499
L+ GG S ++ V+ Y+P ENRW A ++ AV I+ +GG
Sbjct: 456 AVLGGFLYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGG 514
Query: 500 DTEFT-AASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCY 558
+ T +SA R++ TNQW+ + MT++R +L VGG+ GT KT++ +
Sbjct: 515 RDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVF 574
Query: 559 DPTSDTW 565
DP ++TW
Sbjct: 575 DPDANTW 581
Score = 83.6 bits (205), Expect = 5e-16
Identities = 53/181 (29%), Positives = 83/181 (45%), Gaps = 12/181 (6%)
Query: 390 LYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVF 449
L+ VGG S ++ VE+YDP N+W MVA + V L+
Sbjct: 320 LFAVGGWCS---------GDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAV 370
Query: 450 GGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAA-AVLGSQIFIMGGDTEFTAASA 508
GG ++ V+ YDP N+W+ R + AVLG ++ +GG + +
Sbjct: 371 GGHD-GSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNI 429
Query: 509 Y-RFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNC 567
R+D + N+WTR+ M+ +R+ G LY VGG GT T++ Y+P + W+
Sbjct: 430 VERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHT 489
Query: 568 I 568
I
Sbjct: 490 I 490
Score = 39.3 bits (90), Expect = 0.010
Identities = 28/103 (27%), Positives = 40/103 (38%), Gaps = 10/103 (9%)
Query: 324 ADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGS 383
A + + RK + +Y GGR +S Y+ +WS M R G G
Sbjct: 491 APMGTRRKHLGCAVYQDMIYAVGGRDDTTELSS-AERYNPRTNQWSPVVAMTSRRSGVGL 549
Query: 384 AELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMM 426
A + L VGG + LK +E +DP AN W +
Sbjct: 550 AVVNGQLMAVGGFDG---------TTYLKTIEVFDPDANTWRL 583
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 280 bits (715), Expect = 3e-75
Identities = 189/574 (32%), Positives = 283/574 (49%), Gaps = 39/574 (6%)
Query: 12 RSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYF 71
+S TG +SH + +L N R +FTDV + + FPCHRAVL+A S YF
Sbjct: 32 KSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYF 91
Query: 72 EAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHD 131
AMF + RESR+ V L E +E L + Y+ ++ I EN + L E + Q
Sbjct: 92 RAMFCNDHRESREMLVEINGIL-AEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISV 150
Query: 132 VRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKD 191
+RDA A+FLE+ L P NCLG+ +D H + L+ L FE V Q E+F L KD
Sbjct: 151 LRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKD 210
Query: 192 TLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVS 251
L+D I SDEL E +VFEA+++WV ++ R+ L ELL VRL LL + + V
Sbjct: 211 ELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVE 270
Query: 252 SEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKA---GHTLLILGGQTFMCD 308
+ L+ ++ EA R IL N+ + SP RPR++ ++++GG C+
Sbjct: 271 VDQLIQNSPECYQLLHEARR--YHILGNE--MMSPRTRPRRSTGYSEVIVVVGG----CE 322
Query: 309 KI--------YQVDHKAKEIIPKADLPS-PRKEFSASAIGCKVYVTGGRGSENGVSKDVW 359
++ D E A LP + E++ A+ + V+GGR + S+DVW
Sbjct: 323 RVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRIN----SRDVW 378
Query: 360 VYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDP 419
+Y++ W + A + R+ H A L +YVVGG+ L VE YD
Sbjct: 379 IYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDG---------QNRLSSVECYDS 429
Query: 420 GANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECP 479
+N+W VAPL++ VS+ AV S KLFV GG KVQ YDP N W ++A P
Sbjct: 430 FSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIP 489
Query: 480 QPWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNK 539
R A L + I++ GG T+ + Y +D + W + + +++ +C K
Sbjct: 490 IAKRCITAVSLNNLIYVAGGLTK----AIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGK 545
Query: 540 LYVVGG-YFGTQRCKTLDCYDPTSDTWNCITTVP 572
+Y++GG + T+ CYDP + + +P
Sbjct: 546 IYILGGRRENGEATDTILCYDPATSIITGVAAMP 579
Score = 58.5 bits (140), Expect = 2e-08
Identities = 42/149 (28%), Positives = 62/149 (41%), Gaps = 15/149 (10%)
Query: 336 SAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGG 395
S +G K++V GG +N S V YD W A + IA+ + L N +YV GG
Sbjct: 451 SCVG-KLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG 509
Query: 396 HTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIH 455
T K + YDP + WM V N + K+++ GG +
Sbjct: 510 LT--------------KAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRREN 555
Query: 456 RDMVSKVQCYDPSENRWTIKAECPQPWRY 484
+ + CYDP+ + T A P+P Y
Sbjct: 556 GEATDTILCYDPATSIITGVAAMPRPVSY 584
Score = 58.2 bits (139), Expect = 2e-08
Identities = 32/121 (26%), Positives = 54/121 (44%), Gaps = 3/121 (2%)
Query: 463 QCYDPSENRWTIKAECPQPWRYT-AAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRI 521
+CYDP W A+ P+ + A L + I + GG + + ++ + N W R+
Sbjct: 333 ECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGG--RINSRDVWIYNSQLNIWIRV 390
Query: 522 GDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFV 581
+ R K+YVVGGY G R +++CYD S+ W + + ++ A
Sbjct: 391 ASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVT 450
Query: 582 S 582
S
Sbjct: 451 S 451
>gi|194097389 kelch-like 38 [Homo sapiens]
Length = 581
Score = 267 bits (683), Expect = 2e-71
Identities = 187/588 (31%), Positives = 284/588 (48%), Gaps = 50/588 (8%)
Query: 17 SMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFS 76
S++ LF +L LN+LR+ + TDV++ AG R PCHR VLA+SS YF AMF
Sbjct: 5 SLDGLLFKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFC 64
Query: 77 HGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAA 136
RE + V + + P L+ ++ + Y+ I +N ++EA MLQF + +A
Sbjct: 65 SSFREKSEAKVQLK-GIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEAC 123
Query: 137 AEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDL 196
+ +L+ L PSNCLGM+ LS+ C L + + + L F V S D L L D
Sbjct: 124 SSYLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDY 183
Query: 197 ISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALL 256
+ D L E+E+ VFEA++ W+KHDL+ RK ++ EL + VRL + ++++ALL
Sbjct: 184 LGDDGLCGEEEK-VFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALL 242
Query: 257 MADERTKLIMDEALRCKTRILQNDGVVTSPC-----ARPRKAGHTLLILGG------QTF 305
+ ++I++ A K ++ G C PR + LIL G QT
Sbjct: 243 QSSPACQIILETA---KRQMFSLCGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTT 299
Query: 306 MCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENG---VSKDVWVYD 362
+Y + + K LP+ + SA + +YV GG +G VS +V+++
Sbjct: 300 RDVLLYSKQTGQWQSLAK--LPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFS 357
Query: 363 TVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGAN 422
+W PML+AR+ H S +N ++ +GG + +E+YD N
Sbjct: 358 LKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGG--------IGEGQELMGSMERYDSICN 409
Query: 423 KWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRW------TIKA 476
W +A + GV + AV +L++FGG I ++ V +Q Y S N W IK
Sbjct: 410 VWESMASMPVGVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKN 469
Query: 477 ECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALAS 536
C A VLG +I I+GG T A +D ++N++ + DM +RM A
Sbjct: 470 VC------APAVVLGERIVIVGGYTRRILA----YDPQSNKFVKCADMKDRRMHHGATVM 519
Query: 537 GNKLYVVGGYFGTQRCK-----TLDCYDPTSDTWNCITTVPYSLIPTA 579
GNKLYV GG T C + DCYDP +DTW +P+ L A
Sbjct: 520 GNKLYVTGGRRLTTDCNIEDSASFDCYDPETDTWTSQGQLPHKLFDHA 567
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 267 bits (682), Expect = 2e-71
Identities = 172/553 (31%), Positives = 270/553 (48%), Gaps = 24/553 (4%)
Query: 23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRES 82
F +H + + +H DV L AGDR P HR VL++ S YF AMF++ +RE+
Sbjct: 151 FQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREA 210
Query: 83 RDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEK 142
R + + + + P L L+ +AY+ R+ + E+N E LL +LQ V +A +FL K
Sbjct: 211 RQEEIKME-GVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMK 269
Query: 143 NLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDEL 202
L PSNCLG+ +DA C L++ + + HF V ++++F L + L++SD++
Sbjct: 270 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDM 329
Query: 203 ETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERT 262
+E + A+L WV+HDLE R+ L +LL +RL LL L + ++ E
Sbjct: 330 NIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQ 389
Query: 263 KLIMDEALRCKTRILQNDGVVTSPCARPRKAG-HTLLILGG--QTFMCDKIYQVDHKAKE 319
KLIM EA++ + + ++ SP +PRK+ TL +GG T I + D +
Sbjct: 390 KLIM-EAMKYHL-LPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNM 447
Query: 320 IIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARF 379
P A++ R +F + + K+YV GGR ++ V Y+ + WS PM R
Sbjct: 448 WTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLN-TVECYNPKTKTWSVMPPMSTHRH 506
Query: 380 GHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAV 439
G G A LE +Y VGGH + L VE++DP A +W VA + S V
Sbjct: 507 GLGVAVLEGPMYAVGGHDGWS---------YLNTVERWDPQARQWNFVATMSTPRSTVGV 557
Query: 440 VSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG 499
KL+ GG + V+C+DP N+WT+ A+ + ++ +GG
Sbjct: 558 AVLSGKLYAVGGRD-GSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG 616
Query: 500 D-------TEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRC 552
T + R+D +T+ WT + M+ R + G+KLY VGGY G
Sbjct: 617 HDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYL 676
Query: 553 KTLDCYDPTSDTW 565
T++ YDP ++ W
Sbjct: 677 NTVEAYDPQTNEW 689
Score = 65.9 bits (159), Expect = 1e-10
Identities = 48/162 (29%), Positives = 71/162 (43%), Gaps = 9/162 (5%)
Query: 314 DHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAP 373
D +A++ A + +PR + + K+Y GGR + + K V +D +W+ A
Sbjct: 536 DPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCL-KSVECFDPHTNKWTLCAQ 594
Query: 374 MLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQ--VEKYDPGANKWMMVAPLR 431
M R G G LY +GGH + PAS S VE+YDP + W VA +
Sbjct: 595 MSKRRGGVGVTTWNGLLYAIGGHDA-----PASNLTSRLSDCVERYDPKTDMWTAVASMS 649
Query: 432 DGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWT 473
V KL+ GG + ++ V+ YDP N WT
Sbjct: 650 ISRDAVGVCLLGDKLYAVGGYD-GQAYLNTVEAYDPQTNEWT 690
Score = 59.7 bits (143), Expect = 7e-09
Identities = 27/74 (36%), Positives = 43/74 (58%), Gaps = 1/74 (1%)
Query: 494 IFIMGG-DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRC 552
+F +GG D+ A S ++D TN WT + +M +R+ +KLYVVGG G +
Sbjct: 423 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 482
Query: 553 KTLDCYDPTSDTWN 566
T++CY+P + TW+
Sbjct: 483 NTVECYNPKTKTWS 496
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/140 (26%), Positives = 62/140 (44%), Gaps = 4/140 (2%)
Query: 446 LFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFT 504
LF GG + S ++ YD N WT A AVL +++++GG D T
Sbjct: 423 LFAVGGMDSTKGATS-IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKT 481
Query: 505 AASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDT 564
+ ++ +T W+ + M+ R +Y VGG+ G T++ +DP +
Sbjct: 482 LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQ 541
Query: 565 WNCITTV--PYSLIPTAFVS 582
WN + T+ P S + A +S
Sbjct: 542 WNFVATMSTPRSTVGVAVLS 561
Score = 31.2 bits (69), Expect = 2.8
Identities = 19/75 (25%), Positives = 32/75 (42%), Gaps = 1/75 (1%)
Query: 306 MCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVH 365
+ D + + D K A + R +G K+Y GG + ++ V YD
Sbjct: 628 LSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNT-VEAYDPQT 686
Query: 366 EEWSKAAPMLIARFG 380
EW++ AP+ + R G
Sbjct: 687 NEWTQVAPLCLGRAG 701
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 267 bits (682), Expect = 2e-71
Identities = 172/553 (31%), Positives = 270/553 (48%), Gaps = 24/553 (4%)
Query: 23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRES 82
F +H + + +H DV L AGDR P HR VL++ S YF AMF++ +RE+
Sbjct: 197 FQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREA 256
Query: 83 RDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEK 142
R + + + + P L L+ +AY+ R+ + E+N E LL +LQ V +A +FL K
Sbjct: 257 RQEEIKME-GVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMK 315
Query: 143 NLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDEL 202
L PSNCLG+ +DA C L++ + + HF V ++++F L + L++SD++
Sbjct: 316 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDM 375
Query: 203 ETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERT 262
+E + A+L WV+HDLE R+ L +LL +RL LL L + ++ E
Sbjct: 376 NIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQ 435
Query: 263 KLIMDEALRCKTRILQNDGVVTSPCARPRKAG-HTLLILGG--QTFMCDKIYQVDHKAKE 319
KLIM EA++ + + ++ SP +PRK+ TL +GG T I + D +
Sbjct: 436 KLIM-EAMKYHL-LPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNM 493
Query: 320 IIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARF 379
P A++ R +F + + K+YV GGR ++ V Y+ + WS PM R
Sbjct: 494 WTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLN-TVECYNPKTKTWSVMPPMSTHRH 552
Query: 380 GHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAV 439
G G A LE +Y VGGH + L VE++DP A +W VA + S V
Sbjct: 553 GLGVAVLEGPMYAVGGHDGWS---------YLNTVERWDPQARQWNFVATMSTPRSTVGV 603
Query: 440 VSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG 499
KL+ GG + V+C+DP N+WT+ A+ + ++ +GG
Sbjct: 604 AVLSGKLYAVGGRD-GSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG 662
Query: 500 D-------TEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRC 552
T + R+D +T+ WT + M+ R + G+KLY VGGY G
Sbjct: 663 HDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYL 722
Query: 553 KTLDCYDPTSDTW 565
T++ YDP ++ W
Sbjct: 723 NTVEAYDPQTNEW 735
Score = 65.9 bits (159), Expect = 1e-10
Identities = 48/162 (29%), Positives = 71/162 (43%), Gaps = 9/162 (5%)
Query: 314 DHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAP 373
D +A++ A + +PR + + K+Y GGR + + K V +D +W+ A
Sbjct: 582 DPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCL-KSVECFDPHTNKWTLCAQ 640
Query: 374 MLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQ--VEKYDPGANKWMMVAPLR 431
M R G G LY +GGH + PAS S VE+YDP + W VA +
Sbjct: 641 MSKRRGGVGVTTWNGLLYAIGGHDA-----PASNLTSRLSDCVERYDPKTDMWTAVASMS 695
Query: 432 DGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWT 473
V KL+ GG + ++ V+ YDP N WT
Sbjct: 696 ISRDAVGVCLLGDKLYAVGGYD-GQAYLNTVEAYDPQTNEWT 736
Score = 59.7 bits (143), Expect = 7e-09
Identities = 27/74 (36%), Positives = 43/74 (58%), Gaps = 1/74 (1%)
Query: 494 IFIMGG-DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRC 552
+F +GG D+ A S ++D TN WT + +M +R+ +KLYVVGG G +
Sbjct: 469 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 528
Query: 553 KTLDCYDPTSDTWN 566
T++CY+P + TW+
Sbjct: 529 NTVECYNPKTKTWS 542
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/140 (26%), Positives = 62/140 (44%), Gaps = 4/140 (2%)
Query: 446 LFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFT 504
LF GG + S ++ YD N WT A AVL +++++GG D T
Sbjct: 469 LFAVGGMDSTKGATS-IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKT 527
Query: 505 AASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDT 564
+ ++ +T W+ + M+ R +Y VGG+ G T++ +DP +
Sbjct: 528 LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQ 587
Query: 565 WNCITTV--PYSLIPTAFVS 582
WN + T+ P S + A +S
Sbjct: 588 WNFVATMSTPRSTVGVAVLS 607
Score = 31.2 bits (69), Expect = 2.8
Identities = 19/75 (25%), Positives = 32/75 (42%), Gaps = 1/75 (1%)
Query: 306 MCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVH 365
+ D + + D K A + R +G K+Y GG + ++ V YD
Sbjct: 674 LSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNT-VEAYDPQT 732
Query: 366 EEWSKAAPMLIARFG 380
EW++ AP+ + R G
Sbjct: 733 NEWTQVAPLCLGRAG 747
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 267 bits (682), Expect = 2e-71
Identities = 176/541 (32%), Positives = 259/541 (47%), Gaps = 17/541 (3%)
Query: 36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHP 95
+N LR + DV + A D HR VLAA S YF AMF+ + ES+ + +D +
Sbjct: 40 MNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKD-VDG 98
Query: 96 EVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLL 155
+ L L+D+ Y++ I + EEN + LL A +LQ DVR +FL+ L P+NCLG+
Sbjct: 99 QTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAF 158
Query: 156 SDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAIL 215
+D H C L + + HF V E+F SLS D + LISSD+L E VFEA++
Sbjct: 159 ADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVI 218
Query: 216 QWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEALRCKTR 275
W+ ++ E R H+ +L+ VRL LLP D L + V EAL+ + K + EA++
Sbjct: 219 SWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLL 278
Query: 276 ILQNDGVVTSPCARPR---KAGHTLLILGGQTFMCDKIYQ-VDHKAKEIIPKADLPSPRK 331
L ++ +P +PR ++++GGQ + + D + A+LPS R
Sbjct: 279 PLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRC 338
Query: 332 EFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLY 391
+ VY GG V + V VYD V ++W+ A M R G+A L + LY
Sbjct: 339 RAGVVFMAGHVYAVGGFNGSLRV-RTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLY 397
Query: 392 VVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGG 451
VGG S L VE Y N+W VAP+ S+ V + KL+ GG
Sbjct: 398 AVGGFDG---------STGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGG 448
Query: 452 -TSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFTAASAY 509
R +S V+ Y+P+ N W A+ VL Q++ GG D S
Sbjct: 449 YDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVE 508
Query: 510 RFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCIT 569
+D TN W ++ DM R + A LYVVGG G+ +++ Y+P +D W +
Sbjct: 509 VYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLP 568
Query: 570 T 570
T
Sbjct: 569 T 569
Score = 51.2 bits (121), Expect = 3e-06
Identities = 27/105 (25%), Positives = 48/105 (45%), Gaps = 3/105 (2%)
Query: 467 PSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTA 526
P + R IK +P L + ++GG S +D E ++W +I ++ +
Sbjct: 279 PLDQRLLIKNPRTKP---RTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPS 335
Query: 527 KRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTV 571
+R + +Y VGG+ G+ R +T+D YD D W I ++
Sbjct: 336 RRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASM 380
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 259 bits (661), Expect = 6e-69
Identities = 177/543 (32%), Positives = 258/543 (47%), Gaps = 21/543 (3%)
Query: 36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHP 95
+N LR + DVT+ A D HR VLAA S YF AMF+ + ESR V ++ +
Sbjct: 50 MNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKE-VDG 108
Query: 96 EVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLL 155
L +L+D+ Y++ I + EEN + LL A +LQ DV+ EFLE L P NCLG+
Sbjct: 109 WTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAF 168
Query: 156 SDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAIL 215
+D H C L + HF V SE+F +L + + LISSD+L E VFEA++
Sbjct: 169 ADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVI 228
Query: 216 QWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEALR---- 271
WV HD + R+ + L+ VRL LLP + L + V EAL+ K + EA++
Sbjct: 229 AWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLL 288
Query: 272 -CKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQ-VDHKAKEIIPKADLPSP 329
+ RIL V + P ++++GGQ + + D K + A+LPS
Sbjct: 289 PTEQRILMKS--VRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSR 346
Query: 330 RKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENC 389
R + V+ GG V + V YD V ++W+ A M R G+A L
Sbjct: 347 RCRAGMVYMAGLVFAVGGFNGSLRV-RTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGL 405
Query: 390 LYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVF 449
LY VGG S L VE Y+ +N+W VAP+ S+ V L+
Sbjct: 406 LYAVGGFDG---------STGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAV 456
Query: 450 GG-TSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFTAAS 507
GG R +S V+CY+ + N WT AE VL + ++ +GG D S
Sbjct: 457 GGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKS 516
Query: 508 AYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNC 567
+D TN W ++ DM R + A LYVVGG G+ +++ Y+PT+D W
Sbjct: 517 VEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTV 576
Query: 568 ITT 570
+++
Sbjct: 577 VSS 579
Score = 75.5 bits (184), Expect = 1e-13
Identities = 54/176 (30%), Positives = 75/176 (42%), Gaps = 11/176 (6%)
Query: 316 KAKEIIPKADLPSPRKEFSASAIGCKVYVTGGR-GSENGVSKDVWVYDTVHEEWSKAAPM 374
K+ E A + + R +G +Y GG G+ V Y+ EW+ A M
Sbjct: 427 KSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM 486
Query: 375 LIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGV 434
R G G L N LY VGGH P V K VE YDP N W VA +
Sbjct: 487 STRRSGAGVGVLNNLLYAVGGHDG--------PLVR-KSVEVYDPTTNAWRQVADMNMCR 537
Query: 435 SNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVL 490
NA V + L+V GG ++ S V+ Y+P+ ++WT+ + C R A +
Sbjct: 538 RNAGVCAVNGLLYVVGGDDGSCNLAS-VEYYNPTTDKWTVVSSCMSTGRSYAGVTV 592
Score = 48.1 bits (113), Expect = 2e-05
Identities = 18/76 (23%), Positives = 38/76 (50%)
Query: 496 IMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTL 555
++GG S +D + +W ++ ++ ++R + ++ VGG+ G+ R +T+
Sbjct: 315 VVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTV 374
Query: 556 DCYDPTSDTWNCITTV 571
D YDP D W + +
Sbjct: 375 DSYDPVKDQWTSVANM 390
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 259 bits (661), Expect = 6e-69
Identities = 177/543 (32%), Positives = 258/543 (47%), Gaps = 21/543 (3%)
Query: 36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHP 95
+N LR + DVT+ A D HR VLAA S YF AMF+ + ESR V ++ +
Sbjct: 46 MNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKE-VDG 104
Query: 96 EVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLL 155
L +L+D+ Y++ I + EEN + LL A +LQ DV+ EFLE L P NCLG+
Sbjct: 105 WTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAF 164
Query: 156 SDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAIL 215
+D H C L + HF V SE+F +L + + LISSD+L E VFEA++
Sbjct: 165 ADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVI 224
Query: 216 QWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEALR---- 271
WV HD + R+ + L+ VRL LLP + L + V EAL+ K + EA++
Sbjct: 225 AWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLL 284
Query: 272 -CKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQ-VDHKAKEIIPKADLPSP 329
+ RIL V + P ++++GGQ + + D K + A+LPS
Sbjct: 285 PTEQRILMKS--VRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSR 342
Query: 330 RKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENC 389
R + V+ GG V + V YD V ++W+ A M R G+A L
Sbjct: 343 RCRAGMVYMAGLVFAVGGFNGSLRV-RTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGL 401
Query: 390 LYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVF 449
LY VGG S L VE Y+ +N+W VAP+ S+ V L+
Sbjct: 402 LYAVGGFDG---------STGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAV 452
Query: 450 GG-TSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFTAAS 507
GG R +S V+CY+ + N WT AE VL + ++ +GG D S
Sbjct: 453 GGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKS 512
Query: 508 AYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNC 567
+D TN W ++ DM R + A LYVVGG G+ +++ Y+PT+D W
Sbjct: 513 VEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTV 572
Query: 568 ITT 570
+++
Sbjct: 573 VSS 575
Score = 75.5 bits (184), Expect = 1e-13
Identities = 54/176 (30%), Positives = 75/176 (42%), Gaps = 11/176 (6%)
Query: 316 KAKEIIPKADLPSPRKEFSASAIGCKVYVTGGR-GSENGVSKDVWVYDTVHEEWSKAAPM 374
K+ E A + + R +G +Y GG G+ V Y+ EW+ A M
Sbjct: 423 KSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM 482
Query: 375 LIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGV 434
R G G L N LY VGGH P V K VE YDP N W VA +
Sbjct: 483 STRRSGAGVGVLNNLLYAVGGHDG--------PLVR-KSVEVYDPTTNAWRQVADMNMCR 533
Query: 435 SNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVL 490
NA V + L+V GG ++ S V+ Y+P+ ++WT+ + C R A +
Sbjct: 534 RNAGVCAVNGLLYVVGGDDGSCNLAS-VEYYNPTTDKWTVVSSCMSTGRSYAGVTV 588
Score = 48.1 bits (113), Expect = 2e-05
Identities = 18/76 (23%), Positives = 38/76 (50%)
Query: 496 IMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTL 555
++GG S +D + +W ++ ++ ++R + ++ VGG+ G+ R +T+
Sbjct: 311 VVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTV 370
Query: 556 DCYDPTSDTWNCITTV 571
D YDP D W + +
Sbjct: 371 DSYDPVKDQWTSVANM 386
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 258 bits (659), Expect = 1e-68
Identities = 166/564 (29%), Positives = 284/564 (50%), Gaps = 34/564 (6%)
Query: 20 VTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRA-FPCHRAVLAASSRYFEAMFSHG 78
+ LF ++HP L T +FTD+TL F CHRAVLAA S YF+AMF+
Sbjct: 10 IYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTAD 69
Query: 79 LRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAE 138
++E + + +H ++LE L+++AY+S+I I + N +SLLEA D+LQF V+ A
Sbjct: 70 MKEKFKNKIKLS-GIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACER 128
Query: 139 FLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLIS 198
FL ++L NC+GM ++ H C L + S R+ F+ V Q E+F +S + L ++S
Sbjct: 129 FLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILS 188
Query: 199 SDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMA 258
L E + E +++W HD+E R L LL + + + P + L+
Sbjct: 189 RKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDIDPVYLKTALGLQRSCLLT 248
Query: 259 DERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAGHTLLILGGQTF-MCDKIYQVDHKA 317
+ + + ++ AL + + +++ T+ I+GG + +++ D
Sbjct: 249 ENKIRSLIYNALNPMHKEIS------------QRSTATMYIIGGYYWHPLSEVHIWDPLT 296
Query: 318 KEIIPKADLPS-PRKEFSASAIGCKVYVTGGRGSENGVSKD-VWVYDTVHEEWSKAAPML 375
I A++P R+ + + +G +YVTGG ++N + D VW+Y++ +EW++ PML
Sbjct: 297 NVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPML 356
Query: 376 IARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVS 435
AR+ H + L C+Y +GG+ A PA ++ E YDP KW+ +A + GV
Sbjct: 357 NARYYHCAVTLGGCVYALGGYRKGA---PA------EEAEFYDPLKEKWIPIANMIKGVG 407
Query: 436 NAAVVSAKLKLFVFGGTSIHRDMVS--KVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQ 493
NA ++V GG +R + KVQ Y+ N W++ P P + ++
Sbjct: 408 NATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENK 467
Query: 494 IFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQ--R 551
++++GG T T +D E N+W I M +RM C A+ +YV GGY ++
Sbjct: 468 LYLVGGQTTITEC----YDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTY 523
Query: 552 CKTLDCYDPTSDTWNCITTVPYSL 575
++++ YDP + W + +P ++
Sbjct: 524 LQSIEKYDPDLNKWEIVGNLPSAM 547
Score = 59.3 bits (142), Expect = 1e-08
Identities = 45/166 (27%), Positives = 67/166 (40%), Gaps = 17/166 (10%)
Query: 321 IPKADLPSPRKEFSASAIGCKVYVTGGRGSENG--VSKDVWVYDTVHEEWSKAAPMLIAR 378
IP A++ +A + +YV GG G V Y++ EWS
Sbjct: 397 IPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPE 456
Query: 379 FGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAA 438
+G S EN LY+VGG T++ E YDP N+W +AP+ +
Sbjct: 457 YGLCSVPFENKLYLVGGQTTIT--------------ECYDPEQNEWREIAPMMERRMECG 502
Query: 439 VVSAKLKLFVFGGTSIHRDM-VSKVQCYDPSENRWTIKAECPQPWR 483
V ++V GG S + + ++ YDP N+W I P R
Sbjct: 503 AVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMR 548
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 258 bits (658), Expect = 1e-68
Identities = 171/558 (30%), Positives = 269/558 (48%), Gaps = 31/558 (5%)
Query: 27 SHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDT 86
+H +L +N+LRK DVTL + FP HR VLAA S YF AMF+ L E
Sbjct: 14 THAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPY 73
Query: 87 VNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFP 146
V+ Q L +E+LLDF Y+ + + EN + LL A +LQ V+ A EFLE L P
Sbjct: 74 VDIQ-GLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDP 132
Query: 147 SNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETED 206
SNCLG+ ++ H C L + + HF V Q E+F LS+ + LI DE++ +
Sbjct: 133 SNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDS 192
Query: 207 ERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIM 266
E VFEA++ WVKH + R+ LP LL+ VR+ LL + + + +E + + + ++
Sbjct: 193 EEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLV 252
Query: 267 DEALRCKTRILQNDGVVTSPCARPR-KAGHTLLILGG---QTFMCDKIYQVDHKAKEIIP 322
DEA + R + + P R R A LL++GG Q D + + D K +E
Sbjct: 253 DEAKKFHLR-PELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSF 311
Query: 323 KADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEE--WSKAAPMLIARFG 380
+ R+ ++ ++ ++YV GG + +S + T E+ W APM + R
Sbjct: 312 LPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGL 371
Query: 381 HGSAELENCLYVVGG------HTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGV 434
G+ L + +YV GG HTS+ E+YDP ++W M+ ++
Sbjct: 372 AGATTLGDMIYVSGGFDGSRRHTSM---------------ERYDPNIDQWSMLGDMQTAR 416
Query: 435 SNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQI 494
A +V A ++ GG ++++ V+ YDP WT A+L I
Sbjct: 417 EGAGLVVASGVIYCLGGYD-GLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHI 475
Query: 495 FIMGG-DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCK 553
+++GG D +S ++ T+ WT + MT R A +LY + GY G
Sbjct: 476 YVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLS 535
Query: 554 TLDCYDPTSDTWNCITTV 571
+++CYDP D+W +T++
Sbjct: 536 SIECYDPIIDSWEVVTSM 553
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 248 bits (634), Expect = 9e-66
Identities = 171/567 (30%), Positives = 273/567 (48%), Gaps = 32/567 (5%)
Query: 23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRES 82
F HP +L LN R+ FTD+ + R F H+ VLA+ S YF+ + +++S
Sbjct: 306 FTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDS 365
Query: 83 ----RDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAE 138
R+ NL +VLELLL+F Y+ + I+ NA++LLEA QFH
Sbjct: 366 GQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVS 425
Query: 139 FLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLIS 198
FLEK L SNCLG++ +++A QC LY + L F V E+ S+SKD + +S
Sbjct: 426 FLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVS 485
Query: 199 SDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMA 258
+D L T+ E +V+E +++W+K D R + ELL VRL + L V +E L+ +
Sbjct: 486 NDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKS 545
Query: 259 DERTKLIMDEALRCKTRILQNDGVVTSPCARPRKA---GHTLLILGGQTFM------CDK 309
E + +++EA R + T P RPR + ++++GG+ +
Sbjct: 546 SEACRDLVNEAKRYHMLPHARQEMQT-PRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVA 604
Query: 310 IYQVDHKAKEIIPKADLP-SPRKEFSASAIGCKVYVTGGRGSENGVS-KDVWVYDTVHEE 367
+ + + + P A LP R+ FS + G +Y++G G E+GV+ DVW Y ++ +
Sbjct: 605 VTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSG--GMESGVTLADVWCYMSLLDN 662
Query: 368 WSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMV 427
W+ + M + R H S + +Y +GG +AG ++ VE+YD N+W V
Sbjct: 663 WNLVSRMTVPRCRHNSLVYDGKIYTLGG-LGVAG--------NVDHVERYDTITNQWEAV 713
Query: 428 APLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAA 487
APL V +AA K++VFGG + +Q Y P N W+ +Y A
Sbjct: 714 APLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPA 773
Query: 488 AVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYF 547
L +FI+GG A + +D E +M R C A+ K+Y GG
Sbjct: 774 VTLNGFVFILGG---AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIV 830
Query: 548 GTQ--RCKTLDCYDPTSDTWNCITTVP 572
++ ++ Y+PT++TW + +P
Sbjct: 831 SSEGPALGNMEAYEPTTNTWTLLPHMP 857
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 248 bits (634), Expect = 9e-66
Identities = 171/567 (30%), Positives = 273/567 (48%), Gaps = 32/567 (5%)
Query: 23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRES 82
F HP +L LN R+ FTD+ + R F H+ VLA+ S YF+ + +++S
Sbjct: 306 FTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDS 365
Query: 83 ----RDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAE 138
R+ NL +VLELLL+F Y+ + I+ NA++LLEA QFH
Sbjct: 366 GQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVS 425
Query: 139 FLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLIS 198
FLEK L SNCLG++ +++A QC LY + L F V E+ S+SKD + +S
Sbjct: 426 FLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVS 485
Query: 199 SDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMA 258
+D L T+ E +V+E +++W+K D R + ELL VRL + L V +E L+ +
Sbjct: 486 NDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKS 545
Query: 259 DERTKLIMDEALRCKTRILQNDGVVTSPCARPRKA---GHTLLILGGQTFM------CDK 309
E + +++EA R + T P RPR + ++++GG+ +
Sbjct: 546 SEACRDLVNEAKRYHMLPHARQEMQT-PRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVA 604
Query: 310 IYQVDHKAKEIIPKADLP-SPRKEFSASAIGCKVYVTGGRGSENGVS-KDVWVYDTVHEE 367
+ + + + P A LP R+ FS + G +Y++G G E+GV+ DVW Y ++ +
Sbjct: 605 VTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSG--GMESGVTLADVWCYMSLLDN 662
Query: 368 WSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMV 427
W+ + M + R H S + +Y +GG +AG ++ VE+YD N+W V
Sbjct: 663 WNLVSRMTVPRCRHNSLVYDGKIYTLGG-LGVAG--------NVDHVERYDTITNQWEAV 713
Query: 428 APLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAA 487
APL V +AA K++VFGG + +Q Y P N W+ +Y A
Sbjct: 714 APLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPA 773
Query: 488 AVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYF 547
L +FI+GG A + +D E +M R C A+ K+Y GG
Sbjct: 774 VTLNGFVFILGG---AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIV 830
Query: 548 GTQ--RCKTLDCYDPTSDTWNCITTVP 572
++ ++ Y+PT++TW + +P
Sbjct: 831 SSEGPALGNMEAYEPTTNTWTLLPHMP 857
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 246 bits (627), Expect = 6e-65
Identities = 178/553 (32%), Positives = 261/553 (47%), Gaps = 31/553 (5%)
Query: 28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTV 87
H + +L LN LR+H D+ L GD H+ VLA+ S YF+AMF+ L E + V
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
Query: 88 NFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPS 147
FQ + L+ ++++AY+ + I+++ ESLL A ++LQ V FLE L P
Sbjct: 77 EFQC-IDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPG 135
Query: 148 NCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDE 207
NC+G+ ++ + CR LY + + +FE V Q+E+F L+ L +++S+D L E
Sbjct: 136 NCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATE 195
Query: 208 RVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMD 267
VF A+ W+K+D++ R+ +L +LL SVRL LL L + L+ D K +++
Sbjct: 196 ETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLN 255
Query: 268 EALRCKTRILQNDGVVTSPCARPRKAGHTLLILGGQT--FMC-DKIYQVDHKAKEIIPKA 324
EAL+ T RPR A L +GG++ F C D + + I A
Sbjct: 256 EALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLA 315
Query: 325 DLPSPRKEFSASAIGCKVYVTGG-----------RGSENGVSKDVWVYDTVHEEWSKAAP 373
L PR EF + KVYV GG R EN V + W DT W+
Sbjct: 316 PLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSV--ECWNPDT--NTWTSLER 371
Query: 374 MLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDG 433
M +R G L LY +GG+ + L+ VEKY P KW VAP+
Sbjct: 372 MNESRSTLGVVVLAGELYALGGYDGQS---------YLQSVEKYIPKIRKWQPVAPMTTT 422
Query: 434 VSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQ 493
S A ++ GG ++ V+ YDPS++ W + A + V+
Sbjct: 423 RSCFAAAVLDGMIYAIGGYGPAH--MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGF 480
Query: 494 IFIMGGDTEFT-AASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRC 552
IF++GG + +S R+D NQWT M R A N LYVVGG+ G+
Sbjct: 481 IFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYL 540
Query: 553 KTLDCYDPTSDTW 565
T+ YDP SDTW
Sbjct: 541 NTVQKYDPISDTW 553
Score = 69.3 bits (168), Expect = 9e-12
Identities = 41/169 (24%), Positives = 74/169 (43%), Gaps = 9/169 (5%)
Query: 411 LKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIH-------RDMVSKVQ 463
L VE Y P + W+ +APL + K++V GG + + R + V+
Sbjct: 298 LDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVE 357
Query: 464 CYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFTAASAYRFDCETNQWTRIG 522
C++P N WT + VL +++ +GG D + S ++ + +W +
Sbjct: 358 CWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVA 417
Query: 523 DMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTV 571
MT R A +Y +GGY G +++ YDP+ D+W + ++
Sbjct: 418 PMTTTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASM 465
Score = 54.3 bits (129), Expect = 3e-07
Identities = 36/104 (34%), Positives = 50/104 (48%), Gaps = 14/104 (13%)
Query: 324 ADLPSPRKEFSASAIGCKVYVTGGRGSENGVS--KDVWVYDTVHEEWSKAAPMLIARFGH 381
A + R F + ++V GG NGVS + YD +W+ PM R G
Sbjct: 463 ASMADKRIHFGVGVMLGFIFVVGGH---NGVSHLSSIERYDPHQNQWTVCRPMKEPRTGV 519
Query: 382 GSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWM 425
G+A ++N LYVVGGH S S L V+KYDP ++ W+
Sbjct: 520 GAAVIDNYLYVVGGH---------SGSSYLNTVQKYDPISDTWL 554
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 245 bits (625), Expect = 9e-65
Identities = 166/569 (29%), Positives = 268/569 (47%), Gaps = 24/569 (4%)
Query: 7 ETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAA 66
+T+ S + + FH +H + L + K DV L AG P HR VL+A
Sbjct: 143 DTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSA 202
Query: 67 SSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDM 126
S YF AMF++ + E++ + V + + P L L+ +AY+ + + E+ ESLL A +
Sbjct: 203 VSDYFAAMFTNDVLEAKQEEVRME-GVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACL 261
Query: 127 LQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFN 186
LQ V D + FL K L PSNCLG+ DA C L + + + HF V ++++F
Sbjct: 262 LQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFL 321
Query: 187 SLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCL 246
L + + L+ SD++ DE +F A++QWV HD++ R+ L LL +RL LLP L
Sbjct: 322 LLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLL 381
Query: 247 QEAVSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAG-HTLLILGGQTF 305
+ +S E KL+M EA++ + + ++ SP +PRK+ L +GG
Sbjct: 382 ADLETSSMFTGDLECQKLLM-EAMKYHL-LPERRSMMQSPRTKPRKSTVGALYAVGGMDA 439
Query: 306 M--CDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDT 363
M I + D + + + R +F + I K+YV GGR ++ V ++
Sbjct: 440 MKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLN-TVECFNP 498
Query: 364 VHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANK 423
V + W+ PM R G G A LE +Y VGGH + L VE++DP +
Sbjct: 499 VGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWS---------YLNTVERWDPEGRQ 549
Query: 424 WMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWR 483
W VA + S VV+ KL+ GG + ++ +DP N+W++ A +
Sbjct: 550 WNYVASMSTPRSTVGVVALNNKLYAIGGRD-GSSCLKSMEYFDPHTNKWSLCAPMSKRRG 608
Query: 484 YTAAAVLGSQIFIMGG-------DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALAS 536
A ++++GG + R+D + + W+ + ++ R +
Sbjct: 609 GVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPL 668
Query: 537 GNKLYVVGGYFGTQRCKTLDCYDPTSDTW 565
G+KLYVVGGY G T++ YD + W
Sbjct: 669 GDKLYVVGGYDGHTYLNTVESYDAQRNEW 697
Score = 75.9 bits (185), Expect = 1e-13
Identities = 46/178 (25%), Positives = 80/178 (44%), Gaps = 11/178 (6%)
Query: 390 LYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVF 449
LY VGG ++ G +EKYD N W+ + + V KL+V
Sbjct: 431 LYAVGGMDAMKGT---------TTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVV 481
Query: 450 GGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAY 509
GG + + + V+C++P WT+ A L ++ +GG ++ +
Sbjct: 482 GGRDGLKTL-NTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV 540
Query: 510 -RFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWN 566
R+D E QW + M+ R + +A NKLY +GG G+ K+++ +DP ++ W+
Sbjct: 541 ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWS 598
Score = 39.3 bits (90), Expect = 0.010
Identities = 28/127 (22%), Positives = 52/127 (40%), Gaps = 2/127 (1%)
Query: 446 LFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFT 504
L+ GG + + ++ YD N W AV+ ++++++GG D T
Sbjct: 431 LYAVGGMDAMKGTTT-IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKT 489
Query: 505 AASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDT 564
+ F+ WT + M+ R +Y VGG+ G T++ +DP
Sbjct: 490 LNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQ 549
Query: 565 WNCITTV 571
WN + ++
Sbjct: 550 WNYVASM 556
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 245 bits (625), Expect = 9e-65
Identities = 166/569 (29%), Positives = 268/569 (47%), Gaps = 24/569 (4%)
Query: 7 ETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAA 66
+T+ S + + FH +H + L + K DV L AG P HR VL+A
Sbjct: 143 DTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSA 202
Query: 67 SSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDM 126
S YF AMF++ + E++ + V + + P L L+ +AY+ + + E+ ESLL A +
Sbjct: 203 VSDYFAAMFTNDVLEAKQEEVRME-GVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACL 261
Query: 127 LQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFN 186
LQ V D + FL K L PSNCLG+ DA C L + + + HF V ++++F
Sbjct: 262 LQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFL 321
Query: 187 SLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCL 246
L + + L+ SD++ DE +F A++QWV HD++ R+ L LL +RL LLP L
Sbjct: 322 LLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLL 381
Query: 247 QEAVSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAG-HTLLILGGQTF 305
+ +S E KL+M EA++ + + ++ SP +PRK+ L +GG
Sbjct: 382 ADLETSSMFTGDLECQKLLM-EAMKYHL-LPERRSMMQSPRTKPRKSTVGALYAVGGMDA 439
Query: 306 M--CDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDT 363
M I + D + + + R +F + I K+YV GGR ++ V ++
Sbjct: 440 MKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLN-TVECFNP 498
Query: 364 VHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANK 423
V + W+ PM R G G A LE +Y VGGH + L VE++DP +
Sbjct: 499 VGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWS---------YLNTVERWDPEGRQ 549
Query: 424 WMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWR 483
W VA + S VV+ KL+ GG + ++ +DP N+W++ A +
Sbjct: 550 WNYVASMSTPRSTVGVVALNNKLYAIGGRD-GSSCLKSMEYFDPHTNKWSLCAPMSKRRG 608
Query: 484 YTAAAVLGSQIFIMGG-------DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALAS 536
A ++++GG + R+D + + W+ + ++ R +
Sbjct: 609 GVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPL 668
Query: 537 GNKLYVVGGYFGTQRCKTLDCYDPTSDTW 565
G+KLYVVGGY G T++ YD + W
Sbjct: 669 GDKLYVVGGYDGHTYLNTVESYDAQRNEW 697
Score = 75.9 bits (185), Expect = 1e-13
Identities = 46/178 (25%), Positives = 80/178 (44%), Gaps = 11/178 (6%)
Query: 390 LYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVF 449
LY VGG ++ G +EKYD N W+ + + V KL+V
Sbjct: 431 LYAVGGMDAMKGT---------TTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVV 481
Query: 450 GGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAY 509
GG + + + V+C++P WT+ A L ++ +GG ++ +
Sbjct: 482 GGRDGLKTL-NTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTV 540
Query: 510 -RFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWN 566
R+D E QW + M+ R + +A NKLY +GG G+ K+++ +DP ++ W+
Sbjct: 541 ERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWS 598
Score = 48.1 bits (113), Expect = 2e-05
Identities = 45/165 (27%), Positives = 58/165 (35%), Gaps = 45/165 (27%)
Query: 324 ADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGS 383
A + +PR A+ K+Y GGR + + K + +D +WS APM R G G
Sbjct: 554 ASMSTPRSTVGVVALNNKLYAIGGRDGSSCL-KSMEYFDPHTNKWSLCAPMSKRRGGVGV 612
Query: 384 AELENCLYVVGGHTSLAG----------------------VFPASPS------------- 408
A LYVVGGH + A V P S
Sbjct: 613 ATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKL 672
Query: 409 ---------VSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKL 444
L VE YD N+W P+ G + A VV KL
Sbjct: 673 YVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVKL 717
Score = 39.3 bits (90), Expect = 0.010
Identities = 28/127 (22%), Positives = 52/127 (40%), Gaps = 2/127 (1%)
Query: 446 LFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFT 504
L+ GG + + ++ YD N W AV+ ++++++GG D T
Sbjct: 431 LYAVGGMDAMKGTTT-IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKT 489
Query: 505 AASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDT 564
+ F+ WT + M+ R +Y VGG+ G T++ +DP
Sbjct: 490 LNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQ 549
Query: 565 WNCITTV 571
WN + ++
Sbjct: 550 WNYVASM 556
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 244 bits (624), Expect = 1e-64
Identities = 167/549 (30%), Positives = 262/549 (47%), Gaps = 24/549 (4%)
Query: 25 KASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRD 84
K + D +A ++ +R+ + D+ L + H+ VLA+ S YF AMF++ + ESR
Sbjct: 72 KRHYHDAFVA-MSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQ 130
Query: 85 DTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNL 144
V D + P+ L+ L+ FAY++ I + E N ++LL A +LQ + VRDA +FL L
Sbjct: 131 THVTLHD-IDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQL 189
Query: 145 FPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELET 204
PSNCLG+ +DAH C L + + R L HF V ++E+F L +L+L+SSD L
Sbjct: 190 DPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNV 249
Query: 205 EDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKL 264
E V+ A+L WVKHD++ R+ H+P L++ VRL LL D L V +E+L+ K
Sbjct: 250 PSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKD 309
Query: 265 IMDEALRCKTRILQNDGVVTSPCARPRK---AGHTLLILGGQTFMC--DKIYQVDHKAKE 319
++ EAL+ + + GV+ + RPR+ AG L +GG + D +
Sbjct: 310 LLIEALKFHL-LPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDR 368
Query: 320 IIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARF 379
A + + R +A+G ++Y GG + ++ V YD V W M R
Sbjct: 369 WHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLA-TVESYDPVTNTWQPEVSMGTRRS 427
Query: 380 GHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAV 439
G A L LY GG+ + L E+YDP W VA + V
Sbjct: 428 CLGVAALHGLLYSAGGYDGAS---------CLNSAERYDPLTGTWTSVAAMSTRRRYVRV 478
Query: 440 VSAKLKLFVFGG--TSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIM 497
+ L+ GG +S H ++ V+ Y+P N W+ A AVL +++
Sbjct: 479 ATLDGNLYAVGGYDSSSH---LATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVA 535
Query: 498 GG-DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLD 556
GG D S R+ + W + M +R + +A LY VGG G+ +++
Sbjct: 536 GGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIE 595
Query: 557 CYDPTSDTW 565
Y+P ++ W
Sbjct: 596 KYNPRTNKW 604
Score = 68.2 bits (165), Expect = 2e-11
Identities = 41/158 (25%), Positives = 68/158 (43%), Gaps = 2/158 (1%)
Query: 415 EKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTI 474
E YD ++W +VA + + V + +L+ GG D+ + V+ YDP N W
Sbjct: 360 EAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLAT-VESYDPVTNTWQP 418
Query: 475 KAECPQPWRYTAAAVLGSQIFIMGG-DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHA 533
+ A L ++ GG D SA R+D T WT + M+ +R
Sbjct: 419 EVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRV 478
Query: 534 LASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTV 571
LY VGGY + T++ Y+P + W+ + ++
Sbjct: 479 ATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASM 516
Score = 50.4 bits (119), Expect = 4e-06
Identities = 36/126 (28%), Positives = 53/126 (42%), Gaps = 10/126 (7%)
Query: 322 PKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGH 381
P A + S R + + +YV GG + ++ V Y W APM I R H
Sbjct: 512 PVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNS-VERYSPKAGAWESVAPMNIRRSTH 570
Query: 382 GSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVS 441
++ LY VGG+ S SL +EKY+P NKW+ + + S+ V
Sbjct: 571 DLVAMDGWLYAVGGNDG---------SSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAV 621
Query: 442 AKLKLF 447
+L F
Sbjct: 622 LELLNF 627
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 244 bits (623), Expect = 2e-64
Identities = 160/515 (31%), Positives = 254/515 (49%), Gaps = 24/515 (4%)
Query: 61 RAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESL 120
R VL++ S YF AMF++ +RE+R + + + + P L L+ +AY+ R+ + E+N E L
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKME-GVEPNSLWSLIQYAYTGRLELKEDNIECL 232
Query: 121 LEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVR 180
L +LQ V +A +FL K L PSNCLG+ +DA C L++ + + HF V
Sbjct: 233 LSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVI 292
Query: 181 QSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLAL 240
++++F L + L++SD++ +E + A+L WV+HDLE R+ L +LL +RL L
Sbjct: 293 RNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPL 352
Query: 241 LPSDCLQEAVSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAG-HTLLI 299
L L + ++ E KLIM EA++ + + ++ SP +PRK+ TL
Sbjct: 353 LAPQFLADMENNVLFRDDIECQKLIM-EAMKYHL-LPERRPMLQSPRTKPRKSTVGTLFA 410
Query: 300 LGG--QTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKD 357
+GG T I + D + P A++ R +F + + K+YV GGR ++
Sbjct: 411 VGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLN-T 469
Query: 358 VWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKY 417
V Y+ + WS PM R G G A LE +Y VGGH + L VE++
Sbjct: 470 VECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS---------YLNTVERW 520
Query: 418 DPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAE 477
DP A +W VA + S V KL+ GG + V+C+DP N+WT+ A+
Sbjct: 521 DPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRD-GSSCLKSVECFDPHTNKWTLCAQ 579
Query: 478 CPQPWRYTAAAVLGSQIFIMGGD-------TEFTAASAYRFDCETNQWTRIGDMTAKRMS 530
+ ++ +GG T + R+D +T+ WT + M+ R +
Sbjct: 580 MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDA 639
Query: 531 CHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTW 565
G+KLY VGGY G T++ YDP ++ W
Sbjct: 640 VGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEW 674
Score = 65.9 bits (159), Expect = 1e-10
Identities = 48/162 (29%), Positives = 71/162 (43%), Gaps = 9/162 (5%)
Query: 314 DHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAP 373
D +A++ A + +PR + + K+Y GGR + + K V +D +W+ A
Sbjct: 521 DPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCL-KSVECFDPHTNKWTLCAQ 579
Query: 374 MLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQ--VEKYDPGANKWMMVAPLR 431
M R G G LY +GGH + PAS S VE+YDP + W VA +
Sbjct: 580 MSKRRGGVGVTTWNGLLYAIGGHDA-----PASNLTSRLSDCVERYDPKTDMWTAVASMS 634
Query: 432 DGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWT 473
V KL+ GG + ++ V+ YDP N WT
Sbjct: 635 ISRDAVGVCLLGDKLYAVGGYD-GQAYLNTVEAYDPQTNEWT 675
Score = 59.7 bits (143), Expect = 7e-09
Identities = 27/74 (36%), Positives = 43/74 (58%), Gaps = 1/74 (1%)
Query: 494 IFIMGG-DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRC 552
+F +GG D+ A S ++D TN WT + +M +R+ +KLYVVGG G +
Sbjct: 408 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 467
Query: 553 KTLDCYDPTSDTWN 566
T++CY+P + TW+
Sbjct: 468 NTVECYNPKTKTWS 481
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/140 (26%), Positives = 62/140 (44%), Gaps = 4/140 (2%)
Query: 446 LFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFT 504
LF GG + S ++ YD N WT A AVL +++++GG D T
Sbjct: 408 LFAVGGMDSTKGATS-IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKT 466
Query: 505 AASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDT 564
+ ++ +T W+ + M+ R +Y VGG+ G T++ +DP +
Sbjct: 467 LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQ 526
Query: 565 WNCITTV--PYSLIPTAFVS 582
WN + T+ P S + A +S
Sbjct: 527 WNFVATMSTPRSTVGVAVLS 546
Score = 31.2 bits (69), Expect = 2.8
Identities = 19/75 (25%), Positives = 32/75 (42%), Gaps = 1/75 (1%)
Query: 306 MCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVH 365
+ D + + D K A + R +G K+Y GG + ++ V YD
Sbjct: 613 LSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNT-VEAYDPQT 671
Query: 366 EEWSKAAPMLIARFG 380
EW++ AP+ + R G
Sbjct: 672 NEWTQVAPLCLGRAG 686
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 242 bits (618), Expect = 6e-64
Identities = 170/553 (30%), Positives = 266/553 (48%), Gaps = 43/553 (7%)
Query: 36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHP 95
L TLR TDV L + F CHR VLAA+S YF AMF + L+E + + + +
Sbjct: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIK-GVDA 120
Query: 96 EVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLL 155
E + LLD+ Y+S+ I ++N + +LEA ++ QF + DA A FL + L P NC+G++ L
Sbjct: 121 ETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRL 180
Query: 156 SDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAIL 215
+D H L + + +F + SE+F L DTL ++ SD+L +E VFE ++
Sbjct: 181 ADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVM 240
Query: 216 QWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEALRCKTR 275
WV+H R LP +L +VRL LL E V ++ L+ ++ EA R
Sbjct: 241 SWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEA-----R 295
Query: 276 ILQNDG-VVTSPCARPRK---AGHTLLILGGQTFMCDKIYQVD----------HKAKEII 321
+ G + S +PR +I+GG T + +V AK +
Sbjct: 296 MYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPL 355
Query: 322 PKADLPSPRK---EFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIAR 378
+ +L S K EF+ + +VY++GG+ +++ DVW Y++ +W + + I R
Sbjct: 356 TEHELESENKKWVEFACVTLKNEVYISGGKETQH----DVWKYNSSINKWIQIEYLNIGR 411
Query: 379 FGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAA 438
+ H L +YV+GG L + VE YDP N W APL VS+ A
Sbjct: 412 WRHKMVVLGGKVYVIGGFDGLQ---------RINNVETYDPFHNCWSEAAPLLVHVSSFA 462
Query: 439 VVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMG 498
S K KL+V GG + K QCYDPS N+W++KA P + A +I+++G
Sbjct: 463 ATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVG 522
Query: 499 GDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGY-FGTQRCKTLDC 557
G + Y + + W + ++ +R SC N+LY+ GG + T+ C
Sbjct: 523 G----AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLC 578
Query: 558 YDPTSD--TWNCI 568
+DP + T C+
Sbjct: 579 WDPEAQKLTEECV 591
Score = 48.1 bits (113), Expect = 2e-05
Identities = 38/138 (27%), Positives = 63/138 (45%), Gaps = 8/138 (5%)
Query: 438 AVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWT-IKAECPQPWRYTAAAVLGSQIFI 496
A V+ K ++++ GG D V Y+ S N+W I+ WR+ VLG ++++
Sbjct: 371 ACVTLKNEVYISGGKETQHD----VWKYNSSINKWIQIEYLNIGRWRHKMV-VLGGKVYV 425
Query: 497 MGG-DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGY-FGTQRCKT 554
+GG D + +D N W+ + S A + KLYV+GG G
Sbjct: 426 IGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDK 485
Query: 555 LDCYDPTSDTWNCITTVP 572
CYDP+++ W+ +P
Sbjct: 486 TQCYDPSTNKWSLKAAMP 503
>gi|128485503 kelch-like 30 [Homo sapiens]
Length = 560
Score = 242 bits (617), Expect = 8e-64
Identities = 166/579 (28%), Positives = 271/579 (46%), Gaps = 55/579 (9%)
Query: 32 VLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQD 91
+L L LR DVTL G R PCHR +LA SS YF AMF+ ES V +D
Sbjct: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRD 60
Query: 92 NLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLG 151
+ P V+ L+DF Y+ R+ I + N E+L L F V+ +L++ L +NCLG
Sbjct: 61 -VEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLG 119
Query: 152 MMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVF 211
+ + + +W +FE V + ++F L ++ L+ ++ D L+ + E+
Sbjct: 120 ICEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRL 179
Query: 212 EAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEALR 271
EA+++WV+HD + R HLPELL V L +P C+Q+ ++SE L+ E + + +
Sbjct: 180 EALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQG-- 237
Query: 272 CKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQ-----------VDHKAKEI 320
+DG +P A +K L+++GGQ ++ + + KAK
Sbjct: 238 -------HDG---APLALQQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRW 287
Query: 321 IPKADLPSPRK-EFSASAIGCKVYVTGG-RGSENGV--SKDVWVYDTVHEEWSKAAPMLI 376
+ D P K FS +A+ +YVTGG RG++ + W + W APML
Sbjct: 288 MALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLK 347
Query: 377 ARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSN 436
R H SA L +YV+GG T + + +VE YDP + W V+P VSN
Sbjct: 348 PRTNHASAALNGEIYVIGGTT-----------LDVVEVESYDPYTDSWTPVSPALKYVSN 396
Query: 437 AAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAE--CPQPWRYTAAAVLGSQI 494
+ + +L++ G ++ + ++ +QCY+P + W++ A P+ A L ++
Sbjct: 397 FSAAGCRGRLYLVGSSACKYNALA-LQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGEL 455
Query: 495 FIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCK- 553
+++G +T+ Y +D N W ++ + + + G+ LYV GG +
Sbjct: 456 YLIGDNTK----KVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDY 511
Query: 554 --TLDCYDPTSDTWNCITTVP----YSLIPTAF--VSTW 584
++ YD DTW +P Y T F VS W
Sbjct: 512 HVEMEAYDTVRDTWTRHGALPRLWLYHGASTVFLDVSKW 550
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 239 bits (611), Expect = 4e-63
Identities = 177/563 (31%), Positives = 268/563 (47%), Gaps = 40/563 (7%)
Query: 23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWA-GDRAFPCHRAVLAASSRYFEAMFSHGLRE 81
F +H +L L+ LR F DVTL A G R FP HRAVLAA+S YF AMF+ LRE
Sbjct: 12 FSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRE 71
Query: 82 SRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
SR + V + P++L+LLLDF+Y+ R+A++ +NAE LL A D+LQF V++A FL+
Sbjct: 72 SRAERVRLH-GVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
Query: 142 KNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDE 201
+ L +NCL M ++A C L + R L H + +E L LL + D
Sbjct: 131 QQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDG 189
Query: 202 LETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADER 261
L E ++ L+WV+ D R H P+LL +VRL + L V +E L+
Sbjct: 190 LCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPP 249
Query: 262 TKLIMDEALRCKTRILQNDGVVTSPCARPRKA---GHTLLILGGQTFMCDKIYQVD---H 315
++ EA + P RPR + L+++GG CD++ VD
Sbjct: 250 CLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNP 309
Query: 316 KAKEIIPKADLPSP-RKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPM 374
+ + A+ P +S A+G +YVTGG + VW Y++ EW++ APM
Sbjct: 310 QTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSR-LYDCVWRYNSSVNEWAEVAPM 368
Query: 375 LIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGV 434
L AR H S+ L+ LYVV ++ E+YD + W + P+ +
Sbjct: 369 LKAREYHSSSVLDGLLYVVAADST----------------ERYDHTTDSWEALQPMTYPM 412
Query: 435 SNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQ--PWRYT--AAAVL 490
N + + + +L+ G + MV +QCYDP + W++ +C Q PW + A +
Sbjct: 413 DNCSTTACRGRLYAIGSLAGKETMV--MQCYDPDTDLWSL-VDCGQLPPWSFAPKTATLN 469
Query: 491 GSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGT- 549
G F+ E + R N+W +I M + G KLYV GGY T
Sbjct: 470 GLMYFVRDDSAEVDVYNPTR-----NEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTF 524
Query: 550 QRCKTLDCYDPTSDTWNCITTVP 572
+ ++ YDP + W+ + +P
Sbjct: 525 ELSDVVEAYDPETRAWSVVGRLP 547
Score = 50.4 bits (119), Expect = 4e-06
Identities = 37/133 (27%), Positives = 57/133 (42%), Gaps = 11/133 (8%)
Query: 446 LFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWR--YTAAAVLGSQIFIMGG-DTE 502
L + GG D + V CY+P +W AE P Y+ A LG+ I++ GG D
Sbjct: 288 LVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVA-LGNDIYVTGGSDGS 346
Query: 503 FTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTS 562
+R++ N+W + M R + LYVV T+R YD T+
Sbjct: 347 RLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAAD-STER------YDHTT 399
Query: 563 DTWNCITTVPYSL 575
D+W + + Y +
Sbjct: 400 DSWEALQPMTYPM 412
Score = 31.2 bits (69), Expect = 2.8
Identities = 17/53 (32%), Positives = 25/53 (47%)
Query: 334 SASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAEL 386
S + +G K+YV+GG + +S V YD WS + F HGS +
Sbjct: 506 SLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSI 558
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 237 bits (604), Expect = 3e-62
Identities = 166/539 (30%), Positives = 253/539 (46%), Gaps = 24/539 (4%)
Query: 36 LNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHP 95
+ +R+ DVTL GD F HR VLAAS YF AMF++ + E + D + Q + P
Sbjct: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQ-GMDP 86
Query: 96 EVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLL 155
LE L++FAY+ +AI+++N +SLL LQ ++DA FL + L P NCLG+
Sbjct: 87 SALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQF 146
Query: 156 SDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVFEAIL 215
++ C LY+ + HF V SE+F +L + +L+L+S DEL + E VFEA L
Sbjct: 147 AETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAAL 206
Query: 216 QWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEALRCKTR 275
WV++D E R +LPELL ++RL L L + V + L+ + + ++DEA K
Sbjct: 207 AWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEA---KDY 263
Query: 276 ILQNDGVVTSPCARPRKAGHT-----LLILGGQTFMCDKIYQV---DHKAKEIIPKADLP 327
L + P R R T + +GG D + V D A +
Sbjct: 264 HLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMT 323
Query: 328 SPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELE 387
+ R + + +Y GG + +S V Y+ + W++ M R G+ L+
Sbjct: 324 TARSRVGVAVVNGLLYAIGGYDGQLRLS-TVEAYNPETDTWTRVGSMNSKRSAMGTVVLD 382
Query: 388 NCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLF 447
+YV GG+ + SL VE Y P +KW +V + S A V + +++
Sbjct: 383 GQIYVCGGYDG---------NSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIY 433
Query: 448 VFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFTAA 506
V GG + S V+ Y+ W A AA LGS++F+ GG D +
Sbjct: 434 VSGGHD-GLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLS 492
Query: 507 SAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTW 565
A + +QW I M +R +AS +LY VGGY G +++ YDP +D W
Sbjct: 493 IAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCW 551
Score = 73.2 bits (178), Expect = 6e-13
Identities = 50/176 (28%), Positives = 80/176 (45%), Gaps = 7/176 (3%)
Query: 397 TSLAGVFPA-----SPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGG 451
TS+AG+ A S SL VE +DP AN W P+ S V L+ GG
Sbjct: 284 TSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGG 343
Query: 452 TSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFTAASAYR 510
+ +S V+ Y+P + WT VL QI++ GG D + +S
Sbjct: 344 YD-GQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVET 402
Query: 511 FDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWN 566
+ ET++WT + M++ R + ++YV GG+ G Q +++ Y+ + TW+
Sbjct: 403 YSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWH 458
Score = 70.1 bits (170), Expect = 5e-12
Identities = 33/127 (25%), Positives = 63/127 (49%), Gaps = 1/127 (0%)
Query: 446 LFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFT 504
++ GG + D ++ V+ +DP N W AV+ ++ +GG D +
Sbjct: 290 IYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLR 349
Query: 505 AASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDT 564
++ ++ ET+ WTR+G M +KR + + ++YV GGY G +++ Y P +D
Sbjct: 350 LSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDK 409
Query: 565 WNCITTV 571
W +T++
Sbjct: 410 WTVVTSM 416
Score = 58.2 bits (139), Expect = 2e-08
Identities = 48/189 (25%), Positives = 82/189 (43%), Gaps = 22/189 (11%)
Query: 298 LILGGQTFMCDKIYQVDHKAKEI---IPKAD-------LPSPRKEFSASAIGCKVYVTGG 347
++L GQ ++C Y + + P+ D + S R + ++YV+GG
Sbjct: 379 VVLDGQIYVCGG-YDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGG 437
Query: 348 RGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASP 407
+ V Y+ W AA ML R HG+A L + ++V GG+
Sbjct: 438 HDGLQ-IFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDG--------- 487
Query: 408 SVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDP 467
S L E Y A++W ++ P+ S ++V++ +L+ GG ++ S V+ YDP
Sbjct: 488 SGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNL-SSVEMYDP 546
Query: 468 SENRWTIKA 476
+ WT A
Sbjct: 547 ETDCWTFMA 555
Score = 46.2 bits (108), Expect = 8e-05
Identities = 40/156 (25%), Positives = 64/156 (41%), Gaps = 17/156 (10%)
Query: 282 VVTSPCARPRKAGHTLL-----ILGGQTFM--CDKIYQVDHKAKEIIPKADLPSPRKEFS 334
VVTS + AG T+ + GG + + +H P A + + R
Sbjct: 412 VVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHG 471
Query: 335 ASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVG 394
A+++G K++V GG +G +Y +V ++W PM R LY VG
Sbjct: 472 AASLGSKMFVCGGYDG-SGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVG 530
Query: 395 GHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPL 430
G+ + +L VE YDP + W +AP+
Sbjct: 531 GYDGQS---------NLSSVEMYDPETDCWTFMAPM 557
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 233 bits (595), Expect = 3e-61
Identities = 162/545 (29%), Positives = 259/545 (47%), Gaps = 27/545 (4%)
Query: 36 LNTLRKHCMFTDVTLW-----AGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQ 90
+N LR DVTL A F H+ VLA+SS F+AMF++GLRE + V+ +
Sbjct: 67 MNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIE 126
Query: 91 DNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCL 150
+HP+V+E L++FAY++ I++ E+ ++ M Q V A ++FL + L PSN +
Sbjct: 127 -GIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Query: 151 GMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVV 210
G+ ++ C L++ + +HF V + E+F +LS L+ LIS D+L E V
Sbjct: 186 GIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEV 245
Query: 211 FEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEAL 270
F A + WVK+D E R+ ++ LLR+VR L + LQ + +L +D R K D +
Sbjct: 246 FHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK---DYLV 302
Query: 271 RCKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQVDHKAKE--IIPKADLPS 328
+ + + PC P K G + GG F Y + + + ADL
Sbjct: 303 KIFEELTLHKPTQVMPCRAP-KVGRLIYTAGGY-FRQSLSYLEAYNPSDGTWLRLADLQV 360
Query: 329 PRKEFSASAIGCKVYVTGGRGSE---NGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAE 385
PR + +G +Y GGR + N S + Y+ + +WS APM + R G
Sbjct: 361 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV 420
Query: 386 LENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLK 445
++ +Y VGG + + VE+Y+P ++W +VAP+ V
Sbjct: 421 IDGHIYAVGG---------SHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
Query: 446 LFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFT 504
L+ GG + ++ +CY P N W + VL + I+ GG D +
Sbjct: 472 LYAVGGFD-GTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQ 530
Query: 505 AASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDT 564
S R+D ET WT + M +R + ++YV+GGY G +++CYDP +DT
Sbjct: 531 LNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDT 590
Query: 565 WNCIT 569
W+ +T
Sbjct: 591 WSEVT 595
Score = 74.3 bits (181), Expect = 3e-13
Identities = 46/166 (27%), Positives = 72/166 (43%), Gaps = 4/166 (2%)
Query: 410 SLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDM---VSKVQCYD 466
SL +E Y+P W+ +A L+ S A L+ GG + D S + CY+
Sbjct: 338 SLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYN 397
Query: 467 PSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTE-FTAASAYRFDCETNQWTRIGDMT 525
P N+W+ A P V+ I+ +GG S R++ E ++W + M
Sbjct: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPML 457
Query: 526 AKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTV 571
+R+ LY VGG+ GT R + +CY P + W IT +
Sbjct: 458 TRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAM 503
Score = 40.0 bits (92), Expect = 0.006
Identities = 28/98 (28%), Positives = 40/98 (40%), Gaps = 10/98 (10%)
Query: 342 VYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAG 401
+Y GG ++ ++ V YD E W+ APM R G + +YV+GG+
Sbjct: 519 IYAAGGYDGQDQLNS-VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDG--- 574
Query: 402 VFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAV 439
L VE YDP + W V + G S V
Sbjct: 575 ------HTFLDSVECYDPDTDTWSEVTRMTSGRSGVGV 606
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 233 bits (595), Expect = 3e-61
Identities = 162/545 (29%), Positives = 259/545 (47%), Gaps = 27/545 (4%)
Query: 36 LNTLRKHCMFTDVTLW-----AGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQ 90
+N LR DVTL A F H+ VLA+SS F+AMF++GLRE + V+ +
Sbjct: 67 MNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIE 126
Query: 91 DNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCL 150
+HP+V+E L++FAY++ I++ E+ ++ M Q V A ++FL + L PSN +
Sbjct: 127 -GIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Query: 151 GMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVV 210
G+ ++ C L++ + +HF V + E+F +LS L+ LIS D+L E V
Sbjct: 186 GIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEV 245
Query: 211 FEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEAL 270
F A + WVK+D E R+ ++ LLR+VR L + LQ + +L +D R K D +
Sbjct: 246 FHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK---DYLV 302
Query: 271 RCKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQVDHKAKE--IIPKADLPS 328
+ + + PC P K G + GG F Y + + + ADL
Sbjct: 303 KIFEELTLHKPTQVMPCRAP-KVGRLIYTAGGY-FRQSLSYLEAYNPSDGTWLRLADLQV 360
Query: 329 PRKEFSASAIGCKVYVTGGRGSE---NGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAE 385
PR + +G +Y GGR + N S + Y+ + +WS APM + R G
Sbjct: 361 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV 420
Query: 386 LENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLK 445
++ +Y VGG + + VE+Y+P ++W +VAP+ V
Sbjct: 421 IDGHIYAVGG---------SHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
Query: 446 LFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFT 504
L+ GG + ++ +CY P N W + VL + I+ GG D +
Sbjct: 472 LYAVGGFD-GTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQ 530
Query: 505 AASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDT 564
S R+D ET WT + M +R + ++YV+GGY G +++CYDP +DT
Sbjct: 531 LNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDT 590
Query: 565 WNCIT 569
W+ +T
Sbjct: 591 WSEVT 595
Score = 74.3 bits (181), Expect = 3e-13
Identities = 46/166 (27%), Positives = 72/166 (43%), Gaps = 4/166 (2%)
Query: 410 SLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDM---VSKVQCYD 466
SL +E Y+P W+ +A L+ S A L+ GG + D S + CY+
Sbjct: 338 SLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYN 397
Query: 467 PSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTE-FTAASAYRFDCETNQWTRIGDMT 525
P N+W+ A P V+ I+ +GG S R++ E ++W + M
Sbjct: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPML 457
Query: 526 AKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTV 571
+R+ LY VGG+ GT R + +CY P + W IT +
Sbjct: 458 TRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAM 503
Score = 40.0 bits (92), Expect = 0.006
Identities = 28/98 (28%), Positives = 40/98 (40%), Gaps = 10/98 (10%)
Query: 342 VYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAG 401
+Y GG ++ ++ V YD E W+ APM R G + +YV+GG+
Sbjct: 519 IYAAGGYDGQDQLNS-VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDG--- 574
Query: 402 VFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAV 439
L VE YDP + W V + G S V
Sbjct: 575 ------HTFLDSVECYDPDTDTWSEVTRMTSGRSGVGV 606
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 225 bits (573), Expect = 1e-58
Identities = 157/500 (31%), Positives = 234/500 (46%), Gaps = 21/500 (4%)
Query: 79 LRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAE 138
+ ESR V ++ + L +L+D+ Y++ I + EEN + LL A +LQ DV+ E
Sbjct: 1 MSESRAKRVRIKE-VDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCE 59
Query: 139 FLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLIS 198
FLE L P NCLG+ +D H C L + HF V SE+F +L + + LIS
Sbjct: 60 FLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLIS 119
Query: 199 SDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMA 258
SD+L E VFEA++ WV HD + R+ + L+ VRL LLP + L + V EAL+
Sbjct: 120 SDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKN 179
Query: 259 DERTKLIMDEALR-----CKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQ- 312
K + EA++ + RIL V + P ++++GGQ + +
Sbjct: 180 SSACKDYLIEAMKYHLLPTEQRILMKS--VRTRLRTPMNLPKLMVVVGGQAPKAIRSVEC 237
Query: 313 VDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAA 372
D K + A+LPS R + V+ GG V + V YD V ++W+ A
Sbjct: 238 YDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRV-RTVDSYDPVKDQWTSVA 296
Query: 373 PMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRD 432
M R G+A L LY VGG S L VE Y+ +N+W VAP+
Sbjct: 297 NMRDRRSTLGAAVLNGLLYAVGGFDG---------STGLSSVEAYNIKSNEWFHVAPMNT 347
Query: 433 GVSNAAVVSAKLKLFVFGG-TSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLG 491
S+ V L+ GG R +S V+CY+ + N WT AE VL
Sbjct: 348 RRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLN 407
Query: 492 SQIFIMGG-DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQ 550
+ ++ +GG D S +D TN W ++ DM R + A LYVVGG G+
Sbjct: 408 NLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSC 467
Query: 551 RCKTLDCYDPTSDTWNCITT 570
+++ Y+PT+D W +++
Sbjct: 468 NLASVEYYNPTTDKWTVVSS 487
Score = 75.5 bits (184), Expect = 1e-13
Identities = 54/176 (30%), Positives = 75/176 (42%), Gaps = 11/176 (6%)
Query: 316 KAKEIIPKADLPSPRKEFSASAIGCKVYVTGGR-GSENGVSKDVWVYDTVHEEWSKAAPM 374
K+ E A + + R +G +Y GG G+ V Y+ EW+ A M
Sbjct: 335 KSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM 394
Query: 375 LIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGV 434
R G G L N LY VGGH P V K VE YDP N W VA +
Sbjct: 395 STRRSGAGVGVLNNLLYAVGGHDG--------PLVR-KSVEVYDPTTNAWRQVADMNMCR 445
Query: 435 SNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVL 490
NA V + L+V GG ++ S V+ Y+P+ ++WT+ + C R A +
Sbjct: 446 RNAGVCAVNGLLYVVGGDDGSCNLAS-VEYYNPTTDKWTVVSSCMSTGRSYAGVTV 500
Score = 48.1 bits (113), Expect = 2e-05
Identities = 18/76 (23%), Positives = 38/76 (50%)
Query: 496 IMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTL 555
++GG S +D + +W ++ ++ ++R + ++ VGG+ G+ R +T+
Sbjct: 223 VVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTV 282
Query: 556 DCYDPTSDTWNCITTV 571
D YDP D W + +
Sbjct: 283 DSYDPVKDQWTSVANM 298
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 224 bits (572), Expect = 1e-58
Identities = 160/577 (27%), Positives = 267/577 (46%), Gaps = 28/577 (4%)
Query: 1 MSVSVHETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCH 60
+S + H S + + H + + + K DV L G+R P H
Sbjct: 167 LSSTGHSMTPQSDLDSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAH 226
Query: 61 RAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESL 120
R VL++ S YF AMF+ + E++ + + + + P L L+ FAY+ + + E+ E+L
Sbjct: 227 RLVLSSVSDYFAAMFTSDVCEAKQEEIKME-GIDPNALWDLVQFAYTGCLELKEDTIENL 285
Query: 121 LEAGDMLQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVR 180
L A +LQ V + FL K L PSNCLG+ +DA C L + + + + V
Sbjct: 286 LAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVI 345
Query: 181 QSEDFNSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLAL 240
++++F L + L L++SD++ DE +F A++ WVK+D++ R L LL +RL L
Sbjct: 346 RNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPL 405
Query: 241 LPSDCLQEAVSSEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAG-HTLLI 299
LP L + + + AL D + ++ EA++ + + ++ SP +PRK+ TL
Sbjct: 406 LPPQILAD-LENHALFKNDLECQKLILEAMKYHL-LPERRTLMQSPRTKPRKSTVGTLYA 463
Query: 300 LGG--QTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKD 357
+GG I + D + I + R +F + I K++V GGR ++
Sbjct: 464 VGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLN-T 522
Query: 358 VWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKY 417
V Y+ + W+ PM R G G LE +Y VGGH + L VE++
Sbjct: 523 VECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWS---------YLNTVERW 573
Query: 418 DPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAE 477
DP + +W VA + S V + KL+ GG +S ++ YDP N+W + A
Sbjct: 574 DPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRD-GSSCLSSMEYYDPHTNKWNMCAP 632
Query: 478 CPQPWRYTAAAVLGSQIFIMGGDTEFTAASAY---------RFDCETNQWTRIGDMTAKR 528
+ A ++ +GG AS + R+D +T+ WT + ++ R
Sbjct: 633 MCKRRGGVGVATCDGFLYAVGGHD--APASNHCSRLLDYVERYDPKTDTWTMVAPLSMPR 690
Query: 529 MSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTW 565
+ G++LY VGGY G T++ YDP ++ W
Sbjct: 691 DAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEW 727
Score = 76.6 bits (187), Expect = 6e-14
Identities = 50/178 (28%), Positives = 77/178 (43%), Gaps = 11/178 (6%)
Query: 390 LYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVF 449
LY VGG + G +EKYD N W+ + V KLFV
Sbjct: 461 LYAVGGMDNNKGA---------TTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVI 511
Query: 450 GGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAY 509
GG + + + V+CY+P WT+ VL I+ +GG ++ +
Sbjct: 512 GGRDGLKTL-NTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTV 570
Query: 510 -RFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWN 566
R+D ++ QWT + M+ R + A KLY VGG G+ +++ YDP ++ WN
Sbjct: 571 ERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWN 628
Score = 53.5 bits (127), Expect = 5e-07
Identities = 23/81 (28%), Positives = 42/81 (51%)
Query: 488 AVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYF 547
+ +G+ + G D A + ++D TN W + G M +R+ +KL+V+GG
Sbjct: 456 STVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRD 515
Query: 548 GTQRCKTLDCYDPTSDTWNCI 568
G + T++CY+P + TW +
Sbjct: 516 GLKTLNTVECYNPKTKTWTVL 536
Score = 44.3 bits (103), Expect = 3e-04
Identities = 29/127 (22%), Positives = 54/127 (42%), Gaps = 2/127 (1%)
Query: 446 LFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFT 504
L+ GG ++ + ++ YD N W AV+ ++F++GG D T
Sbjct: 461 LYAVGGMDNNKGATT-IEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKT 519
Query: 505 AASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDT 564
+ ++ +T WT + M+ R +Y VGG+ G T++ +DP S
Sbjct: 520 LNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQ 579
Query: 565 WNCITTV 571
W + ++
Sbjct: 580 WTFVASM 586
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 222 bits (565), Expect = 9e-58
Identities = 166/567 (29%), Positives = 253/567 (44%), Gaps = 38/567 (6%)
Query: 23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRES 82
F H +LA +N +R F DV L G +F HR VLAASS YF A+F+ G++ES
Sbjct: 14 FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKES 73
Query: 83 RDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEK 142
D V + + ++LLDF Y+ + I N + L+ A DMLQ +V EFL+
Sbjct: 74 SKDVVPIL-GIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKG 132
Query: 143 NLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDEL 202
+ P NC+G+ S+ C L EFS VHF V E+F +L+KD L+ ++ S+EL
Sbjct: 133 QIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEEL 192
Query: 203 ETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQ---EAVSSEALLMAD 259
EDE VF A +QW+ DL R+ H+ E+L +R LLP L E VS L +A
Sbjct: 193 SIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVAL 252
Query: 260 ERTKLIMDEALRCKT-RILQNDGVVTSPCARPR-KAGHTLLILGGQTFMCDKIYQVDHKA 317
+ L+ + CK+ + + + + RPR KA L +GG T + + D +A
Sbjct: 253 Q--TLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWS-DSRA 309
Query: 318 KEIIPKAD-----------LPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHE 366
+ + D L R + +G VY GG ++ + YD V +
Sbjct: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE-KDSMIFDCTECYDPVTK 368
Query: 367 EWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMM 426
+W+ A M R G G +Y +GG + +E++DP NKW +
Sbjct: 369 QWTTVASMNHPRCGLGVCVCYGAIYALGGWVG---------AEIGNTIERFDPDENKWEV 419
Query: 427 VAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTA 486
V + + ++V GG S + + YDP RW+ Y
Sbjct: 420 VGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLG 479
Query: 487 AAVLGSQIFIMGG--DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVG 544
A L I+ +GG +T+ + ++ E +W + M R +A LYV G
Sbjct: 480 VAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSG 539
Query: 545 G------YFGTQRCKTLDCYDPTSDTW 565
G + +++ Y+P SDTW
Sbjct: 540 GRSSSHDFLAPGTLDSVEVYNPHSDTW 566
Score = 52.0 bits (123), Expect = 2e-06
Identities = 31/128 (24%), Positives = 51/128 (39%), Gaps = 5/128 (3%)
Query: 450 GGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTE---FTAA 506
GG +S V+ +D WT + Q VLG ++ +GG+ + F
Sbjct: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT 360
Query: 507 SAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWN 566
Y D T QWT + M R +Y +GG+ G + T++ +DP + W
Sbjct: 361 ECY--DPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWE 418
Query: 567 CITTVPYS 574
+ + S
Sbjct: 419 VVGNMAVS 426
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 214 bits (544), Expect = 2e-55
Identities = 159/569 (27%), Positives = 259/569 (45%), Gaps = 26/569 (4%)
Query: 7 ETRKSRSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAA 66
E + +ST + K S C + N LR DV + F H+ +L +
Sbjct: 2 EMESAAASTRFHQPHMERKMSAMACEI--FNELRLEGKLCDVVIKVNGFEFSAHKNILCS 59
Query: 67 SSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDM 126
S YF A+F+ G + N + P++++L++++AY+ + I +N E LL A D
Sbjct: 60 CSSYFRALFTSGWNNTEKKVYNIP-GISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQ 118
Query: 127 LQFHDVRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFET-VRQSEDF 185
+ EFL+ L NC+G+ +D + C L + ++ L +FE V+ S +F
Sbjct: 119 FNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEF 178
Query: 186 NSLSKDTLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDC 245
LS L D+I DEL + E VFEAIL+W+ HD + RK H+ LL VRLAL+ ++
Sbjct: 179 LELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEY 238
Query: 246 LQEAVSSEALLMADERTKLIMDEALRCKTRILQN---DGVVTSPCARPRKAGHTLLILGG 302
V + E K ++ AL+ + N + T+P RPR L +GG
Sbjct: 239 FMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGG 298
Query: 303 QT--FMCDKIYQVDHKA-KEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVW 359
+ + I D +A + + + SPR A+ + VY+ GG S + V
Sbjct: 299 WSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVD-YFNSVK 357
Query: 360 VYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDP 419
+D V + W + APM R L N +Y +GG V L E+Y+P
Sbjct: 358 RFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGY---------VRLNTAERYEP 408
Query: 420 GANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECP 479
N+W ++AP+ + S+A+ + K+++ GG + + + + Y+ N+WT+ A P
Sbjct: 409 ETNQWTLIAPMHEQRSDASATTLYGKVYICGGFN-GNECLFTAEVYNTESNQWTVIA--P 465
Query: 480 QPWRYTAAAVL--GSQIFIMGG-DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALAS 536
R + V+ G ++ +GG D SA + N W I M R +
Sbjct: 466 MRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVV 525
Query: 537 GNKLYVVGGYFGTQRCKTLDCYDPTSDTW 565
+ L+VVGG+ G ++CYD +D W
Sbjct: 526 DDLLFVVGGFNGFTTTFNVECYDEKTDEW 554
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 213 bits (543), Expect = 3e-55
Identities = 160/541 (29%), Positives = 242/541 (44%), Gaps = 32/541 (5%)
Query: 23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRES 82
F H +LA +N +R F DV L G +F HR VLAASS YF A+F+ G++ES
Sbjct: 14 FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKES 73
Query: 83 RDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEK 142
D V + + ++LLDF Y+ + I N + L+ A DMLQ +V EFL+
Sbjct: 74 SKDVVPIL-GIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKG 132
Query: 143 NLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDEL 202
+ P NC+G+ S+ C L EFS VHF V E+F +L+KD L+ ++ S+EL
Sbjct: 133 QIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEEL 192
Query: 203 ETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQ---EAVSSEALLMAD 259
EDE VF A +QW+ DL R+ H+ E+L +R LLP L E VS L +A
Sbjct: 193 SIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVAL 252
Query: 260 ERTKLIMDEALRCKT-RILQNDGVVTSPCARPR-KAGHTLLILGGQTFMCDKIYQVDHKA 317
+ L+ + CK+ + + + + RPR KA L +GG T + + D +A
Sbjct: 253 Q--TLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWS-DSRA 309
Query: 318 KEIIPKAD-----------LPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHE 366
+ + D L R + +G VY GG ++ + YD V +
Sbjct: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE-KDSMIFDCTECYDPVTK 368
Query: 367 EWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMM 426
+W+ A M R G G +Y +GG + +E++DP NKW +
Sbjct: 369 QWTTVASMNHPRCGLGVCVCYGAIYALGGWVG---------AEIGNTIERFDPDENKWEV 419
Query: 427 VAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTA 486
V + + ++V GG S + + YDP RW+ Y
Sbjct: 420 VGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLG 479
Query: 487 AAVLGSQIFIMGG--DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVG 544
A L I+ +GG +T+ + ++ E +W + M R +A LYV G
Sbjct: 480 VAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSG 539
Query: 545 G 545
G
Sbjct: 540 G 540
Score = 57.4 bits (137), Expect = 4e-08
Identities = 38/119 (31%), Positives = 54/119 (45%), Gaps = 8/119 (6%)
Query: 342 VYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAG 401
+YV GG +E + VYD + + WS PM R G A L +C+Y VGG
Sbjct: 439 IYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQD 498
Query: 402 VFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVS 460
+L VEKY KW+ VA ++ + VV+ L+V GG S D ++
Sbjct: 499 --------ALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLA 549
Score = 52.0 bits (123), Expect = 2e-06
Identities = 31/128 (24%), Positives = 51/128 (39%), Gaps = 5/128 (3%)
Query: 450 GGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTE---FTAA 506
GG +S V+ +D WT + Q VLG ++ +GG+ + F
Sbjct: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT 360
Query: 507 SAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWN 566
Y D T QWT + M R +Y +GG+ G + T++ +DP + W
Sbjct: 361 ECY--DPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWE 418
Query: 567 CITTVPYS 574
+ + S
Sbjct: 419 VVGNMAVS 426
Score = 33.9 bits (76), Expect = 0.43
Identities = 22/85 (25%), Positives = 33/85 (38%)
Query: 314 DHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAP 373
D +K P + + R +A+ +Y GG V Y E+W + A
Sbjct: 459 DPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVAS 518
Query: 374 MLIARFGHGSAELENCLYVVGGHTS 398
M + R G + LYV GG +S
Sbjct: 519 MKVPRAGMCVVAVNGLLYVSGGRSS 543
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.133 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,444,184
Number of Sequences: 37866
Number of extensions: 968636
Number of successful extensions: 3455
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 157
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 1968
Number of HSP's gapped (non-prelim): 420
length of query: 589
length of database: 18,247,518
effective HSP length: 108
effective length of query: 481
effective length of database: 14,157,990
effective search space: 6809993190
effective search space used: 6809993190
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.