Search of human proteins with 21359929

Search of human proteins with 21359929

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21359929 X-prolyl aminopeptidase (aminopeptidase P) 1,
soluble [Homo sapiens]
         (623 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21359929 X-prolyl aminopeptidase (aminopeptidase P) 1, solubl...  1277   0.0  
gi|93141226 X-prolyl aminopeptidase 2, membrane-bound [Homo sapi...   492   e-139
gi|149589008 peptidase D [Homo sapiens]                                48   3e-05
gi|11559925 X-prolyl aminopeptidase (aminopeptidase P) 3, putati...    46   1e-04
gi|22325377 sudD suppressor of bimD6 homolog [Homo sapiens]            37   0.042
gi|40385867 methionine aminopeptidase 1D [Homo sapiens]                35   0.27 
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  30   5.1  
gi|5803092 methionyl aminopeptidase 2 [Homo sapiens]                   30   6.6  
gi|4826669 cadherin 15 preproprotein [Homo sapiens]                    30   8.7  

>gi|21359929 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
           [Homo sapiens]
          Length = 623

 Score = 1277 bits (3305), Expect = 0.0
 Identities = 623/623 (100%), Positives = 623/623 (100%)

Query: 1   MPPKVTSELLRQLRQAMRNSEYVTEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSA 60
           MPPKVTSELLRQLRQAMRNSEYVTEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSA
Sbjct: 1   MPPKVTSELLRQLRQAMRNSEYVTEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSA 60

Query: 61  GTAIITEEHAAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVD 120
           GTAIITEEHAAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVD
Sbjct: 61  GTAIITEEHAAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVD 120

Query: 121 PLIIPTDYWKKMAKVLRSAGHHLIPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKD 180
           PLIIPTDYWKKMAKVLRSAGHHLIPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKD
Sbjct: 121 PLIIPTDYWKKMAKVLRSAGHHLIPVKENLVDKIWTDRPERPCKPLLTLGLDYTGISWKD 180

Query: 181 KVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGD 240
           KVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGD
Sbjct: 181 KVADLRLKMAERNVMWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGD 240

Query: 241 RIDAPSVKEHLLLDLGLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSDKASYAVSE 300
           RIDAPSVKEHLLLDLGLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSDKASYAVSE
Sbjct: 241 RIDAPSVKEHLLLDLGLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSDKASYAVSE 300

Query: 301 TIPKDHRCCMPYTPICIAKAVKNSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEI 360
           TIPKDHRCCMPYTPICIAKAVKNSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEI
Sbjct: 301 TIPKDHRCCMPYTPICIAKAVKNSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEI 360

Query: 361 SAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQY 420
           SAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQY
Sbjct: 361 SAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQY 420

Query: 421 KDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSG 480
           KDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSG
Sbjct: 421 KDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSG 480

Query: 481 LDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVV 540
           LDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVV
Sbjct: 481 LDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVV 540

Query: 541 LVVPVKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKEL 600
           LVVPVKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKEL
Sbjct: 541 LVVPVKTKYNFNNRGSLTFEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKEL 600

Query: 601 QKQGRQEALEWLIRETQPISKQH 623
           QKQGRQEALEWLIRETQPISKQH
Sbjct: 601 QKQGRQEALEWLIRETQPISKQH 623


>gi|93141226 X-prolyl aminopeptidase 2, membrane-bound [Homo
           sapiens]
          Length = 674

 Score =  492 bits (1266), Expect = e-139
 Identities = 262/620 (42%), Positives = 384/620 (61%), Gaps = 25/620 (4%)

Query: 6   TSELLRQLRQAMRNSEYVTEPIQAYIIPSGDAHQSEYIAPCDCRRAFVSGFDGSAGTAII 65
           T+  L  LRQ M+     T+ + AYIIP  DAH +EYI   D RRA+++GF GSAGTA++
Sbjct: 50  TTMSLTALRQQMQ-----TQNLSAYIIPGTDAHMNEYIGQHDERRAWITGFTGSAGTAVV 104

Query: 66  TEEHAAMWTDGRYFLQAAKQMDSNWTLMKMGLKDTPTQEDWLVSVLPEGSRVGVDPLIIP 125
           T + AA+WTD RY+ QA +QMD NW L K  +  TP    WL++ +P G RVG DP ++ 
Sbjct: 105 TMKKAAVWTDSRYWTQAERQMDCNWELHKE-VGTTPIVT-WLLTEIPAGGRVGFDPFLLS 162

Query: 126 TDYWKKMAKVLRSAGHHLIPVKENLVDKIW-TDRPERPCKPLLTLGLDYTGISWKDKVAD 184
            D W+     L+ +   L+ +  NLVD +W ++RP  P +P+  L   +TG +W++KV+ 
Sbjct: 163 IDTWESYDLALQGSNRQLVSITTNLVDLVWGSERPPVPNQPIYALQEAFTGSTWQEKVSG 222

Query: 185 LRLKMAERNVMWFVV--TALDEIAWLFNLRGSDVEHNPVFFSYAIIGLETIMLFIDGDRI 242
           +R +M +   +   V  +AL+E AWLFNLR SD+ +NP F+SY ++   +I LF +  R 
Sbjct: 223 VRSQMQKHQKVPTAVLLSALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIRLFANKSRF 282

Query: 243 DAPSVKEHLLLDLGLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSDKAS-YAVSET 301
            + ++     L+        +Q+  Y  +   ++A         ++W+    + Y + E 
Sbjct: 283 SSETLS---YLNSSCTGPMCVQIEDYSQVRDSIQAYSLG---DVRIWIGTSYTMYGIYEM 336

Query: 302 IPKDHRCCMPYTPICIAKAVKNSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEIS 361
           IPK+      Y+P+ + KAVKNS E   ++ +H++DAVA+     WLEK VPKG V E S
Sbjct: 337 IPKEKLVTDTYSPVMMTKAVKNSKEQALLKASHVRDAVAVIRYLVWLEKNVPKGTVDEFS 396

Query: 362 AADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQYK 421
            A+  ++FR ++      SF TIS++G N A+ HY+P  E NR LS DE+YL+DSG QY 
Sbjct: 397 GAEIVDKFRGEEQFSSGPSFETISASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYW 456

Query: 422 DGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGL 481
           DGTTD+TRT+H+GTP+A++KE +T VL G+I +S  +FP  T G ++++FAR ALWD+GL
Sbjct: 457 DGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGL 516

Query: 482 DYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVL 541
           +Y HGTGHG+G+FL VHE P G      +   +  GM  + EPGYY+DG FGIR+E+V L
Sbjct: 517 NYGHGTGHGIGNFLCVHEWPVGFQSNNIA---MAKGMFTSIEPGYYKDGEFGIRLEDVAL 573

Query: 542 VVPVKTKYNFNNRGS-LTFEPLTLVPIQTKMIDVDSLTDKECDWLNNYHLTCRDVIGKEL 600
           VV  KTKY     GS LTFE ++ VP    +IDV  L+ +   +LN Y+ T R+ +G EL
Sbjct: 574 VVEAKTKY----PGSYLTFEVVSFVPYDRNLIDVSLLSPEHLQYLNRYYQTIREKVGPEL 629

Query: 601 QKQGRQEALEWLIRETQPIS 620
           Q++   E  EWL + T+P++
Sbjct: 630 QRRQLLEEFEWLQQHTEPLA 649


>gi|149589008 peptidase D [Homo sapiens]
          Length = 493

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 54/209 (25%), Positives = 85/209 (40%), Gaps = 41/209 (19%)

Query: 354 KGGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETN-RTLSLDEVY 412
           K G+ E       E +   +      S+  I  +G N A++HY      N RT+   ++ 
Sbjct: 214 KVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMC 273

Query: 413 LIDSGAQYKDGTTDVTRTMHF-GTPTAYEKECFTYVLKGHIAVSAAVFP---------TG 462
           L D G +Y    +D+T +    G  TA +K  +  VL+   AV  A+ P           
Sbjct: 274 LFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLA 333

Query: 463 TKGHLLDSFARSALWDSGLDYL-----------HGTGHGVGSFLNVHE---GPCGISYKT 508
            + H L+  A   +    +D +           HG GH +G  ++VH+    P G+    
Sbjct: 334 DRIH-LEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLG--IDVHDVGGYPEGVER-- 388

Query: 509 FSDEP----------LEAGMIVTDEPGYY 527
             DEP          L+ GM++T EPG Y
Sbjct: 389 -IDEPGLRSLRTARHLQPGMVLTVEPGIY 416


>gi|11559925 X-prolyl aminopeptidase (aminopeptidase P) 3, putative
           [Homo sapiens]
          Length = 507

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 67/255 (26%), Positives = 105/255 (41%), Gaps = 49/255 (19%)

Query: 319 KAVKNSAESEGMRRAHIKDAVALCELFNWLEKEVPKGGVTEISAADKAE-EFRRQQADFV 377
           + +K+ AE E M+ A    + A  E          K  V E     K E E R + AD  
Sbjct: 244 RLIKSPAEIERMQIAGKLTSQAFIETMF-----TSKAPVEEAFLYAKFEFECRARGADI- 297

Query: 378 DLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHF-GTP 436
            L++P + + G     +HY    + N+ +   E+ L+D G +     +D+TRT    G  
Sbjct: 298 -LAYPPVVAGGNRSNTLHYV---KNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRF 353

Query: 437 TAYEKECFTYVLKGHIAVSAAVFPTGTKGH------------------LLDSFARSALWD 478
           TA + E +  VL+      A  FP GT                     ++ +   +  + 
Sbjct: 354 TAPQAELYEAVLEIQRDCLALCFP-GTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFK 412

Query: 479 SGLDYL-HGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGMIVTDEPGYY--EDG----- 530
           +   Y  H  GH +G  ++VH+ P           PL+ GM++T EPG Y  ED      
Sbjct: 413 AARKYCPHHVGHYLG--MDVHDTP-----DMPRSLPLQPGMVITIEPGIYIPEDDKDAPE 465

Query: 531 ---AFGIRIENVVLV 542
                G+RIE+ V+V
Sbjct: 466 KFRGLGVRIEDDVVV 480


>gi|22325377 sudD suppressor of bimD6 homolog [Homo sapiens]
          Length = 519

 Score = 37.4 bits (85), Expect = 0.042
 Identities = 30/115 (26%), Positives = 56/115 (48%), Gaps = 7/115 (6%)

Query: 233 IMLFIDGDRIDAPSVKEHLLLDLGLEAEYRIQVHPYKSILSELKALCADLSPREKVWVSD 292
           +M FI  D++ AP +KE  L    ++  Y   +H  + +  E   + ADLS    +W + 
Sbjct: 358 VMSFIGHDQVPAPKLKEVKLNSEEMKEAYYQTLHLMRQLYHECTLVHADLSEYNMLWHAG 417

Query: 293 KA-SYAVSETIPKDHRCCMPYTPICIAKAVKNSAESEGMRRAHIKDAVALCELFN 346
           K     VS+++   H    P+    + +  +N   S+  ++  +K+A++  ELFN
Sbjct: 418 KVWLIDVSQSVEPTH----PHGLEFLFRDCRN--VSQFFQKGGVKEALSERELFN 466


>gi|40385867 methionine aminopeptidase 1D [Homo sapiens]
          Length = 335

 Score = 34.7 bits (78), Expect = 0.27
 Identities = 47/189 (24%), Positives = 68/189 (35%), Gaps = 19/189 (10%)

Query: 381 FPTISSTGPNGAIIHYAPVPETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYE 440
           FP    T  N  + H  P    +R L   ++  ID    Y     D + T   G      
Sbjct: 147 FPKSVCTSVNNVLCHGIP---DSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGNVDECG 203

Query: 441 KECFTYVLKGH---IAVSAAVFPTGTKGHLLDSFARSALWDSGLDYL-HGTGHGVGSFLN 496
           K+      +     IA   A  P    G+ +          +G     H  GHG+GS+ +
Sbjct: 204 KKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQ----NGFQVCPHFVGHGIGSYFH 259

Query: 497 VHEGPCGISYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPVKTKYNFNNRGS 556
            H  P    +   SD P+E GM  T EP   E       +E+   VV      + +N+ S
Sbjct: 260 GH--PEIWHHANDSDLPMEEGMAFTIEPIITEGSPEFKVLEDAWTVV------SLDNQRS 311

Query: 557 LTFEPLTLV 565
             FE   L+
Sbjct: 312 AQFEHTVLI 320


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 30.4 bits (67), Expect = 5.1
 Identities = 22/78 (28%), Positives = 39/78 (50%), Gaps = 6/78 (7%)

Query: 163 CKPLLTLGLDYTGISWKDKVADLRLKMAERNVMWFVVTALDEIAWLFNLR-----GSDVE 217
           C  L  L L Y  I   +K+ D  LK+ E N+ +  ++ ++ I  + NL+     G+++E
Sbjct: 124 CVKLEVLNLSYNLIGKIEKL-DKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIE 182

Query: 218 HNPVFFSYAIIGLETIML 235
           H PV+    +  L  + L
Sbjct: 183 HIPVWLGKKLKSLRVLNL 200


>gi|5803092 methionyl aminopeptidase 2 [Homo sapiens]
          Length = 478

 Score = 30.0 bits (66), Expect = 6.6
 Identities = 24/84 (28%), Positives = 32/84 (38%), Gaps = 6/84 (7%)

Query: 354 KGGVTEISAADKAEEFRR----QQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLD 409
           K G+T I   +K E+  R    +      L+FPT  S   N    HY P       L  D
Sbjct: 188 KPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSL--NNCAAHYTPNAGDTTVLQYD 245

Query: 410 EVYLIDSGAQYKDGTTDVTRTMHF 433
           ++  ID G        D   T+ F
Sbjct: 246 DICKIDFGTHISGRIIDCAFTVTF 269


>gi|4826669 cadherin 15 preproprotein [Homo sapiens]
          Length = 814

 Score = 29.6 bits (65), Expect = 8.7
 Identities = 40/165 (24%), Positives = 56/165 (33%), Gaps = 21/165 (12%)

Query: 354 KGGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPVPETNRTLSLDEVYL 413
           +GG  E   A    + R   A  + L  P +    P G + H  P P    T  LD    
Sbjct: 657 QGGGEEDQDAYDISQLRHPTALSLPLGPPPLRRDAPQGRL-HPQP-PRVLPTSPLDIADF 714

Query: 414 IDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFAR 473
           I+ G +  D    V     + T   Y+     Y   G +A        GT   +L S   
Sbjct: 715 INDGLEAADSDPSVPP---YDTALIYD-----YEGDGSVA--------GTLSSILSSQGD 758

Query: 474 SALWDSGLDYLHGTGHGVGSFLNVHEGPCGISYKTFSDEPLEAGM 518
               D   DYL   G       +++  PCG+ Y    D     G+
Sbjct: 759 E---DQDYDYLRDWGPRFARLADMYGHPCGLEYGARWDHQAREGL 800


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,522,462
Number of Sequences: 37866
Number of extensions: 1107294
Number of successful extensions: 2033
Number of sequences better than 10.0: 9
Number of HSP's better than 10.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 2021
Number of HSP's gapped (non-prelim): 10
length of query: 623
length of database: 18,247,518
effective HSP length: 108
effective length of query: 515
effective length of database: 14,157,990
effective search space: 7291364850
effective search space used: 7291364850
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.