Search of human proteins with 21359854

Search of human proteins with 21359854

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21359854 RAB geranylgeranyltransferase, beta subunit [Homo
sapiens]
         (331 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21359854 RAB geranylgeranyltransferase, beta subunit [Homo sa...   687   0.0  
gi|10835059 farnesyltransferase, CAAX box, beta [Homo sapiens]        146   2e-35
gi|167860116 geranylgeranyltransferase type 1 beta [Homo sapiens]     136   3e-32
gi|224177558 lanosterol synthase isoform 3 [Homo sapiens]              32   0.60 
gi|224177556 lanosterol synthase isoform 2 [Homo sapiens]              32   0.60 
gi|47933395 lanosterol synthase isoform 1 [Homo sapiens]               32   0.60 
gi|47933397 lanosterol synthase isoform 1 [Homo sapiens]               32   0.60 
gi|116812606 zinc finger, H2C2 domain containing [Homo sapiens]        29   6.6  

>gi|21359854 RAB geranylgeranyltransferase, beta subunit [Homo
           sapiens]
          Length = 331

 Score =  687 bits (1773), Expect = 0.0
 Identities = 331/331 (100%), Positives = 331/331 (100%)

Query: 1   MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLM 60
           MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLM
Sbjct: 1   MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLM 60

Query: 61  GQLHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDVNKVV 120
           GQLHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDVNKVV
Sbjct: 61  GQLHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDVNKVV 120

Query: 121 EYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGG 180
           EYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGG
Sbjct: 121 EYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGG 180

Query: 181 FGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVC 240
           FGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVC
Sbjct: 181 FGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVC 240

Query: 241 YSWWVLASLKIIGRLHWIDREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSL 300
           YSWWVLASLKIIGRLHWIDREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSL
Sbjct: 241 YSWWVLASLKIIGRLHWIDREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSL 300

Query: 301 LGEEQIKPVNPVFCMPEEVLQRVNVQPELVS 331
           LGEEQIKPVNPVFCMPEEVLQRVNVQPELVS
Sbjct: 301 LGEEQIKPVNPVFCMPEEVLQRVNVQPELVS 331


>gi|10835059 farnesyltransferase, CAAX box, beta [Homo sapiens]
          Length = 437

 Score =  146 bits (369), Expect = 2e-35
 Identities = 96/336 (28%), Positives = 164/336 (48%), Gaps = 36/336 (10%)

Query: 21  EKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQ-LHRMNREEILAFIKSCQ 79
           EKH  Y+     +  D   C+ +  R    YW L  ++L+ + + ++   ++  F++ CQ
Sbjct: 76  EKHFHYLKRGLRQLTDAYECL-DASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQ 134

Query: 80  HECGGISASIGHDPHLLYTLSAVQILTLY---DSINVIDVNKVVEYVKGLQKEDGSFAGD 136
              GG     G  PHL  T +AV  L +    ++ ++I+  K+++Y+  L++ DGSF   
Sbjct: 135 SPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFLMH 194

Query: 137 IWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYC 196
           + GE+D R ++CA +  +L   +     E   E++  C N++GG G  PG E+H G  +C
Sbjct: 195 VGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFC 254

Query: 197 CTGFLAITSQLHQVNSDLLGWWLCERQLP-SGGLNGRPEKLPDVCYSWWVLASLKIIGRL 255
               L I  +   +N   L  W+  RQ+   GG  GR  KL D CYS+W    L ++ R 
Sbjct: 255 GLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRA 314

Query: 256 ------------HWI-DREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSL-- 300
                       HW+  ++ L+ +IL C     GG  D+PG   D +HT + ++GLS+  
Sbjct: 315 LHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQ 374

Query: 301 --------------LGEEQIKPVNPVFCM-PEEVLQ 321
                         + E  ++P +PV+ + P++V+Q
Sbjct: 375 HFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQ 410


>gi|167860116 geranylgeranyltransferase type 1 beta [Homo sapiens]
          Length = 377

 Score =  136 bits (342), Expect = 3e-32
 Identities = 95/317 (29%), Positives = 152/317 (47%), Gaps = 34/317 (10%)

Query: 39  YCMSEYLRMSGIYWGLTVMDLMGQLHRMNREEILAFIKSCQ----------HECG----- 83
           Y   E  R++  ++ L+ +D++  L  +N+++I+ +I S Q          + CG     
Sbjct: 40  YSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSS 99

Query: 84  --GISASIGHDP---------HLLYTLSAVQILTLY-DSINVIDVNKVVEYVKGLQKEDG 131
             GI  +    P         H+  T + +  L +  D ++ ++    +  ++ LQ EDG
Sbjct: 100 YLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDG 159

Query: 132 SFAGDIWG-EIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESH 190
           SF     G E D RF +CA     +L     ++++KAI ++   M++D G     G ESH
Sbjct: 160 SFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESH 219

Query: 191 AGQIYCCTGFLAITSQLHQVNSDL----LGWWLCERQLPSGGLNGRPEKLPDVCYSWWVL 246
            G  +C    L +  +L +V S+     +  W   RQ    G +GRP K  D CYS+WV 
Sbjct: 220 GGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQ--QNGYHGRPNKPVDTCYSFWVG 277

Query: 247 ASLKIIGRLHWIDREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQI 306
           A+LK++    + + EK RN+IL+ QD   GGFA  P    D  H  FGI GLSL+ E  I
Sbjct: 278 ATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGI 337

Query: 307 KPVNPVFCMPEEVLQRV 323
             V+P   +     +R+
Sbjct: 338 CKVHPALNVSTRTSERL 354


>gi|224177558 lanosterol synthase isoform 3 [Homo sapiens]
          Length = 652

 Score = 32.3 bits (72), Expect = 0.60
 Identities = 34/123 (27%), Positives = 57/123 (46%), Gaps = 16/123 (13%)

Query: 120 VEYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKL-----DAINVEKAIEFVLSC 174
           +E+ +  Q+ DGS+ G  WG   T  ++  +   A +G+          V +A +F+LS 
Sbjct: 484 LEFCRRQQRADGSWEGS-WGVCFTYGTWFGLEAFACMGQTYRDGTACAEVSRACDFLLSR 542

Query: 175 MNFDGGFG-----C--RPGSESHAGQIY-CCTGFLAITSQLH-QVNSDLLG-WWLCERQL 224
              DGG+G     C  R   +S   QI+  C   + + +  H  + +   G   L E+QL
Sbjct: 543 QMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQL 602

Query: 225 PSG 227
           P+G
Sbjct: 603 PNG 605


>gi|224177556 lanosterol synthase isoform 2 [Homo sapiens]
          Length = 721

 Score = 32.3 bits (72), Expect = 0.60
 Identities = 34/123 (27%), Positives = 57/123 (46%), Gaps = 16/123 (13%)

Query: 120 VEYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKL-----DAINVEKAIEFVLSC 174
           +E+ +  Q+ DGS+ G  WG   T  ++  +   A +G+          V +A +F+LS 
Sbjct: 553 LEFCRRQQRADGSWEGS-WGVCFTYGTWFGLEAFACMGQTYRDGTACAEVSRACDFLLSR 611

Query: 175 MNFDGGFG-----C--RPGSESHAGQIY-CCTGFLAITSQLH-QVNSDLLG-WWLCERQL 224
              DGG+G     C  R   +S   QI+  C   + + +  H  + +   G   L E+QL
Sbjct: 612 QMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQL 671

Query: 225 PSG 227
           P+G
Sbjct: 672 PNG 674


>gi|47933395 lanosterol synthase isoform 1 [Homo sapiens]
          Length = 732

 Score = 32.3 bits (72), Expect = 0.60
 Identities = 34/123 (27%), Positives = 57/123 (46%), Gaps = 16/123 (13%)

Query: 120 VEYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKL-----DAINVEKAIEFVLSC 174
           +E+ +  Q+ DGS+ G  WG   T  ++  +   A +G+          V +A +F+LS 
Sbjct: 564 LEFCRRQQRADGSWEGS-WGVCFTYGTWFGLEAFACMGQTYRDGTACAEVSRACDFLLSR 622

Query: 175 MNFDGGFG-----C--RPGSESHAGQIY-CCTGFLAITSQLH-QVNSDLLG-WWLCERQL 224
              DGG+G     C  R   +S   QI+  C   + + +  H  + +   G   L E+QL
Sbjct: 623 QMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQL 682

Query: 225 PSG 227
           P+G
Sbjct: 683 PNG 685


>gi|47933397 lanosterol synthase isoform 1 [Homo sapiens]
          Length = 732

 Score = 32.3 bits (72), Expect = 0.60
 Identities = 34/123 (27%), Positives = 57/123 (46%), Gaps = 16/123 (13%)

Query: 120 VEYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKL-----DAINVEKAIEFVLSC 174
           +E+ +  Q+ DGS+ G  WG   T  ++  +   A +G+          V +A +F+LS 
Sbjct: 564 LEFCRRQQRADGSWEGS-WGVCFTYGTWFGLEAFACMGQTYRDGTACAEVSRACDFLLSR 622

Query: 175 MNFDGGFG-----C--RPGSESHAGQIY-CCTGFLAITSQLH-QVNSDLLG-WWLCERQL 224
              DGG+G     C  R   +S   QI+  C   + + +  H  + +   G   L E+QL
Sbjct: 623 QMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQL 682

Query: 225 PSG 227
           P+G
Sbjct: 683 PNG 685


>gi|116812606 zinc finger, H2C2 domain containing [Homo sapiens]
          Length = 522

 Score = 28.9 bits (63), Expect = 6.6
 Identities = 11/24 (45%), Positives = 13/24 (54%)

Query: 52  WGLTVMDLMGQLHRMNREEILAFI 75
           W L  +DLMG  H  NR  + A I
Sbjct: 140 WSLVTVDLMGPFHTSNRSHVYAII 163


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.140    0.443 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,269,777
Number of Sequences: 37866
Number of extensions: 591995
Number of successful extensions: 996
Number of sequences better than 10.0: 8
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 969
Number of HSP's gapped (non-prelim): 12
length of query: 331
length of database: 18,247,518
effective HSP length: 103
effective length of query: 228
effective length of database: 14,347,320
effective search space: 3271188960
effective search space used: 3271188960
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.