Search of human proteins with 21237732

Search of human proteins with 21237732

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21237732 megalencephalic leukoencephalopathy with
subcortical cysts 1 gene product [Homo sapiens]
         (377 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14589896 megalencephalic leukoencephalopathy with subcortical...   740   0.0  
gi|21237732 megalencephalic leukoencephalopathy with subcortical...   740   0.0  
gi|119395748 potassium voltage-gated channel subfamily A member ...    37   0.029
gi|32528268 glutamate receptor, metabotropic 7 isoform b precurs...    30   2.7  
gi|4504147 glutamate receptor, metabotropic 7 isoform a precurso...    30   2.7  
gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens]             30   3.6  
gi|88758565 potassium voltage-gated channel, shaker-related subf...    30   4.6  
gi|157419142 tumor necrosis factor (ligand) superfamily, member ...    30   4.6  
gi|239751670 PREDICTED: similar to hCG16318 [Homo sapiens]             29   6.1  
gi|148596974 TXK tyrosine kinase [Homo sapiens]                        29   6.1  
gi|24475816 glycoprotein, synaptic 2 [Homo sapiens]                    29   6.1  
gi|4826782 potassium voltage-gated channel, shaker-related subfa...    29   7.9  

>gi|14589896 megalencephalic leukoencephalopathy with subcortical
           cysts 1 gene product [Homo sapiens]
          Length = 377

 Score =  740 bits (1911), Expect = 0.0
 Identities = 377/377 (100%), Positives = 377/377 (100%)

Query: 1   MTQEPFREELAYDRMPTLERGRQDPASYAPDAKPSDLQLSKRLPPCFSHKTWVFSVLMGS 60
           MTQEPFREELAYDRMPTLERGRQDPASYAPDAKPSDLQLSKRLPPCFSHKTWVFSVLMGS
Sbjct: 1   MTQEPFREELAYDRMPTLERGRQDPASYAPDAKPSDLQLSKRLPPCFSHKTWVFSVLMGS 60

Query: 61  CLLVTSGFSLYLGNVFPAEMDYLRCAAGSCIPSAIVSFTVSRRNANVIPNFQILFVSTFA 120
           CLLVTSGFSLYLGNVFPAEMDYLRCAAGSCIPSAIVSFTVSRRNANVIPNFQILFVSTFA
Sbjct: 61  CLLVTSGFSLYLGNVFPAEMDYLRCAAGSCIPSAIVSFTVSRRNANVIPNFQILFVSTFA 120

Query: 121 VTTTCLIWFGCKLVLNPSAININFNLILLLLLELLMAATVIIAARSSEEDCKKKKGSMSD 180
           VTTTCLIWFGCKLVLNPSAININFNLILLLLLELLMAATVIIAARSSEEDCKKKKGSMSD
Sbjct: 121 VTTTCLIWFGCKLVLNPSAININFNLILLLLLELLMAATVIIAARSSEEDCKKKKGSMSD 180

Query: 181 SANILDEVPFPARVLKSYSVVEVIAGISAVLGGIIALNVDDSVSGPHLSVTFFWILVACF 240
           SANILDEVPFPARVLKSYSVVEVIAGISAVLGGIIALNVDDSVSGPHLSVTFFWILVACF
Sbjct: 181 SANILDEVPFPARVLKSYSVVEVIAGISAVLGGIIALNVDDSVSGPHLSVTFFWILVACF 240

Query: 241 PSAIASHVAAECPSKCLVEVLIAISSLTSPLLFTASGYLSFSIMRIVEMFKDYPPAIKPS 300
           PSAIASHVAAECPSKCLVEVLIAISSLTSPLLFTASGYLSFSIMRIVEMFKDYPPAIKPS
Sbjct: 241 PSAIASHVAAECPSKCLVEVLIAISSLTSPLLFTASGYLSFSIMRIVEMFKDYPPAIKPS 300

Query: 301 YDVLLLLLLLVLLLQAGLNTGTAIQCVRFKVSARLQGASWDTQNGPQERLAGEVARSPLK 360
           YDVLLLLLLLVLLLQAGLNTGTAIQCVRFKVSARLQGASWDTQNGPQERLAGEVARSPLK
Sbjct: 301 YDVLLLLLLLVLLLQAGLNTGTAIQCVRFKVSARLQGASWDTQNGPQERLAGEVARSPLK 360

Query: 361 EFDKEKAWRAVVVQMAQ 377
           EFDKEKAWRAVVVQMAQ
Sbjct: 361 EFDKEKAWRAVVVQMAQ 377


>gi|21237732 megalencephalic leukoencephalopathy with subcortical
           cysts 1 gene product [Homo sapiens]
          Length = 377

 Score =  740 bits (1911), Expect = 0.0
 Identities = 377/377 (100%), Positives = 377/377 (100%)

Query: 1   MTQEPFREELAYDRMPTLERGRQDPASYAPDAKPSDLQLSKRLPPCFSHKTWVFSVLMGS 60
           MTQEPFREELAYDRMPTLERGRQDPASYAPDAKPSDLQLSKRLPPCFSHKTWVFSVLMGS
Sbjct: 1   MTQEPFREELAYDRMPTLERGRQDPASYAPDAKPSDLQLSKRLPPCFSHKTWVFSVLMGS 60

Query: 61  CLLVTSGFSLYLGNVFPAEMDYLRCAAGSCIPSAIVSFTVSRRNANVIPNFQILFVSTFA 120
           CLLVTSGFSLYLGNVFPAEMDYLRCAAGSCIPSAIVSFTVSRRNANVIPNFQILFVSTFA
Sbjct: 61  CLLVTSGFSLYLGNVFPAEMDYLRCAAGSCIPSAIVSFTVSRRNANVIPNFQILFVSTFA 120

Query: 121 VTTTCLIWFGCKLVLNPSAININFNLILLLLLELLMAATVIIAARSSEEDCKKKKGSMSD 180
           VTTTCLIWFGCKLVLNPSAININFNLILLLLLELLMAATVIIAARSSEEDCKKKKGSMSD
Sbjct: 121 VTTTCLIWFGCKLVLNPSAININFNLILLLLLELLMAATVIIAARSSEEDCKKKKGSMSD 180

Query: 181 SANILDEVPFPARVLKSYSVVEVIAGISAVLGGIIALNVDDSVSGPHLSVTFFWILVACF 240
           SANILDEVPFPARVLKSYSVVEVIAGISAVLGGIIALNVDDSVSGPHLSVTFFWILVACF
Sbjct: 181 SANILDEVPFPARVLKSYSVVEVIAGISAVLGGIIALNVDDSVSGPHLSVTFFWILVACF 240

Query: 241 PSAIASHVAAECPSKCLVEVLIAISSLTSPLLFTASGYLSFSIMRIVEMFKDYPPAIKPS 300
           PSAIASHVAAECPSKCLVEVLIAISSLTSPLLFTASGYLSFSIMRIVEMFKDYPPAIKPS
Sbjct: 241 PSAIASHVAAECPSKCLVEVLIAISSLTSPLLFTASGYLSFSIMRIVEMFKDYPPAIKPS 300

Query: 301 YDVLLLLLLLVLLLQAGLNTGTAIQCVRFKVSARLQGASWDTQNGPQERLAGEVARSPLK 360
           YDVLLLLLLLVLLLQAGLNTGTAIQCVRFKVSARLQGASWDTQNGPQERLAGEVARSPLK
Sbjct: 301 YDVLLLLLLLVLLLQAGLNTGTAIQCVRFKVSARLQGASWDTQNGPQERLAGEVARSPLK 360

Query: 361 EFDKEKAWRAVVVQMAQ 377
           EFDKEKAWRAVVVQMAQ
Sbjct: 361 EFDKEKAWRAVVVQMAQ 377


>gi|119395748 potassium voltage-gated channel subfamily A member 1
           [Homo sapiens]
          Length = 495

 Score = 37.0 bits (84), Expect = 0.029
 Identities = 38/155 (24%), Positives = 66/155 (42%), Gaps = 11/155 (7%)

Query: 104 NANVIPNFQILFVSTFAVTTTCLIWFGCKLVLN----PSAININFNLILLLLLELLMAAT 159
           N  VI N  I     F V T C+IWF  +LV+     PS  +   N++  + +  ++   
Sbjct: 207 NTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYF 266

Query: 160 VIIAARSSEEDCKKKKGSMSDSANILDEVPFPARVLKSYSVVEVIAGISAVLGGIIALNV 219
           + +    +E++   +KG  + S  IL  +    RV + + +     G+      I+   +
Sbjct: 267 ITLGTEIAEQE-GNQKGEQATSLAILRVIRL-VRVFRIFKLSRHSKGLQ-----ILGQTL 319

Query: 220 DDSVSGPHLSVTFFWILVACFPSAIASHVAAECPS 254
             S+    L + F +I V  F SA+    A E  S
Sbjct: 320 KASMRELGLLIFFLFIGVILFSSAVYFAEAEEAES 354


>gi|32528268 glutamate receptor, metabotropic 7 isoform b precursor
           [Homo sapiens]
          Length = 922

 Score = 30.4 bits (67), Expect = 2.7
 Identities = 26/105 (24%), Positives = 42/105 (40%), Gaps = 12/105 (11%)

Query: 85  CAAGSCIPSAIVSFTVSRRNANVIPNFQILFVSTFAVTTTCLIW-------FGC-----K 132
           C+ G  I   +     + +   V  NF       F + TTC++W       FG      K
Sbjct: 758 CSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEK 817

Query: 133 LVLNPSAININFNLILLLLLELLMAATVIIAARSSEEDCKKKKGS 177
           L +  + + I+ NL   + L +L    V I     E + +K+K S
Sbjct: 818 LYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRS 862


>gi|4504147 glutamate receptor, metabotropic 7 isoform a precursor
           [Homo sapiens]
          Length = 915

 Score = 30.4 bits (67), Expect = 2.7
 Identities = 26/105 (24%), Positives = 42/105 (40%), Gaps = 12/105 (11%)

Query: 85  CAAGSCIPSAIVSFTVSRRNANVIPNFQILFVSTFAVTTTCLIW-------FGC-----K 132
           C+ G  I   +     + +   V  NF       F + TTC++W       FG      K
Sbjct: 758 CSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEK 817

Query: 133 LVLNPSAININFNLILLLLLELLMAATVIIAARSSEEDCKKKKGS 177
           L +  + + I+ NL   + L +L    V I     E + +K+K S
Sbjct: 818 LYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRS 862


>gi|17975768 ephrin receptor EphB3 precursor [Homo sapiens]
          Length = 998

 Score = 30.0 bits (66), Expect = 3.6
 Identities = 14/35 (40%), Positives = 21/35 (60%)

Query: 61  CLLVTSGFSLYLGNVFPAEMDYLRCAAGSCIPSAI 95
           C   T+GF+L+   +  AE   L  A G+CIP+A+
Sbjct: 212 CASTTAGFALFPETLTGAEPTSLVIAPGTCIPNAV 246


>gi|88758565 potassium voltage-gated channel, shaker-related
           subfamily, member 3 [Homo sapiens]
          Length = 575

 Score = 29.6 bits (65), Expect = 4.6
 Identities = 40/173 (23%), Positives = 73/173 (42%), Gaps = 19/173 (10%)

Query: 76  FPAEMDYLRCAAGSCIPSAIVSFTVSRRNANVIPNFQILFVSTFAVTTTCLIWFGCKLVL 135
           F  E DY    +     +A  S + SR  A+   +F   F   F V T C+IWF  +L++
Sbjct: 259 FRDEKDYPASTSQDSFEAAGNSTSGSRAGAS---SFSDPF---FVVETLCIIWFSFELLV 312

Query: 136 N----PSAININFNLILLLLLELLMAATVIIAARSSEEDCKKKKGSMSDSANILDEVPFP 191
                PS    + N++ L+ +  ++   + +    +E   ++  G  + S  IL  +   
Sbjct: 313 RFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAE---RQGNGQQAMSLAILRVIRL- 368

Query: 192 ARVLKSYSVVEVIAGISAVLGGIIALNVDDSVSGPHLSVTFFWILVACFPSAI 244
            RV + + +     G+      I+   +  S+    L + F +I V  F SA+
Sbjct: 369 VRVFRIFKLSRHSKGLQ-----ILGQTLKASMRELGLLIFFLFIGVILFSSAV 416


>gi|157419142 tumor necrosis factor (ligand) superfamily, member 18
           [Homo sapiens]
          Length = 199

 Score = 29.6 bits (65), Expect = 4.6
 Identities = 14/50 (28%), Positives = 28/50 (56%), Gaps = 2/50 (4%)

Query: 176 GSMSDSANILDEVPFPARVLKSYSVVEVIAGISAV--LGGIIALNVDDSV 223
           G ++ +AN  D  PF  R+ K+  +++ +   S +  +GG   L+V D++
Sbjct: 121 GQVAPNANYNDVAPFEVRLYKNKDMIQTLTNKSKIQNVGGTYELHVGDTI 170


>gi|239751670 PREDICTED: similar to hCG16318 [Homo sapiens]
          Length = 166

 Score = 29.3 bits (64), Expect = 6.1
 Identities = 18/77 (23%), Positives = 36/77 (46%), Gaps = 7/77 (9%)

Query: 231 TFFWILVAC--FPSAIASHVAAECPSKCLVEVLIAISSLTSPLLFTASGYLSFSIMRIVE 288
           T+ ++LV+C  +   + S +     ++CL   L ++   T   ++    + S+     ++
Sbjct: 95  TWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSY-----LK 149

Query: 289 MFKDYPPAIKPSYDVLL 305
            F+DYPP   P    LL
Sbjct: 150 EFRDYPPLRMPIIPFLL 166


>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score = 29.3 bits (64), Expect = 6.1
 Identities = 12/28 (42%), Positives = 19/28 (67%)

Query: 57  LMGSCLLVTSGFSLYLGNVFPAEMDYLR 84
           LMGSCL  T+GFS     + P+E+ +++
Sbjct: 248 LMGSCLPATAGFSYEKWEIDPSELAFIK 275


>gi|24475816 glycoprotein, synaptic 2 [Homo sapiens]
          Length = 308

 Score = 29.3 bits (64), Expect = 6.1
 Identities = 18/77 (23%), Positives = 36/77 (46%), Gaps = 7/77 (9%)

Query: 231 TFFWILVAC--FPSAIASHVAAECPSKCLVEVLIAISSLTSPLLFTASGYLSFSIMRIVE 288
           T+ ++LV+C  +   + S +     ++CL   L ++   T   ++    + S+     ++
Sbjct: 237 TWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSY-----LK 291

Query: 289 MFKDYPPAIKPSYDVLL 305
            F+DYPP   P    LL
Sbjct: 292 EFRDYPPLRMPIIPFLL 308


>gi|4826782 potassium voltage-gated channel, shaker-related
           subfamily, member 2 [Homo sapiens]
          Length = 499

 Score = 28.9 bits (63), Expect = 7.9
 Identities = 27/130 (20%), Positives = 56/130 (43%), Gaps = 10/130 (7%)

Query: 119 FAVTTTCLIWFGCKLVLN----PSAININFNLILLLLLELLMAATVIIAARSSEEDCKKK 174
           F V T C+IWF  + ++     PS      N++ ++ +  ++   + +    +E+    +
Sbjct: 223 FIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQ 282

Query: 175 KGSMSDSANILDEVPFPARVLKSYSVVEVIAGISAVLGGIIALNVDDSVSGPHLSVTFFW 234
           +G  + S  IL  +    RV + + +     G+      I+   +  S+    L + F +
Sbjct: 283 QGQQAMSLAILRVIRL-VRVFRIFKLSRHSKGLQ-----ILGQTLKASMRELGLLIFFLF 336

Query: 235 ILVACFPSAI 244
           I V  F SA+
Sbjct: 337 IGVILFSSAV 346


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.136    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,655,004
Number of Sequences: 37866
Number of extensions: 545087
Number of successful extensions: 1734
Number of sequences better than 10.0: 12
Number of HSP's better than 10.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1724
Number of HSP's gapped (non-prelim): 13
length of query: 377
length of database: 18,247,518
effective HSP length: 104
effective length of query: 273
effective length of database: 14,309,454
effective search space: 3906480942
effective search space used: 3906480942
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.