Search of human proteins with 20127652

Search of human proteins with 20127652

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|20127652 presenilin associated, rhomboid-like isoform 1
preproprotein [Homo sapiens]
         (379 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|20127652 presenilin associated, rhomboid-like isoform 1 prepr...   786   0.0  
gi|83641878 presenilin associated, rhomboid-like isoform 2 prepr...   662   0.0  
gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens]           35   0.11 
gi|190341097 rhomboid family 1 [Homo sapiens]                          35   0.15 
gi|10863903 thyroid hormone receptor interactor 12 [Homo sapiens]      30   3.6  
gi|210147475 zinc finger protein 92 homolog [Homo sapiens]             30   4.7  
gi|148839292 ATPase type 13A3 [Homo sapiens]                           29   8.0  

>gi|20127652 presenilin associated, rhomboid-like isoform 1
           preproprotein [Homo sapiens]
          Length = 379

 Score =  786 bits (2030), Expect = 0.0
 Identities = 379/379 (100%), Positives = 379/379 (100%)

Query: 1   MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV 60
           MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV
Sbjct: 1   MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV 60

Query: 61  EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ 120
           EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ
Sbjct: 61  EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ 120

Query: 121 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF 180
           YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF
Sbjct: 121 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF 180

Query: 181 CLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNIL 240
           CLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNIL
Sbjct: 181 CLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNIL 240

Query: 241 GQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIF 300
           GQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIF
Sbjct: 241 GQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIF 300

Query: 301 LPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPL 360
           LPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPL
Sbjct: 301 LPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPL 360

Query: 361 VKIWHEIRTNGPKKGGGSK 379
           VKIWHEIRTNGPKKGGGSK
Sbjct: 361 VKIWHEIRTNGPKKGGGSK 379


>gi|83641878 presenilin associated, rhomboid-like isoform 2
           preproprotein [Homo sapiens]
          Length = 329

 Score =  662 bits (1709), Expect = 0.0
 Identities = 328/379 (86%), Positives = 328/379 (86%), Gaps = 50/379 (13%)

Query: 1   MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV 60
           MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV
Sbjct: 1   MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV 60

Query: 61  EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ 120
           EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ
Sbjct: 61  EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ 120

Query: 121 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF 180
           YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF
Sbjct: 121 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF 180

Query: 181 CLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNIL 240
           CLWRVPSLQRTMIRYFTSNPAS V                                    
Sbjct: 181 CLWRVPSLQRTMIRYFTSNPASSV------------------------------------ 204

Query: 241 GQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIF 300
                         ISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIF
Sbjct: 205 --------------ISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIF 250

Query: 301 LPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPL 360
           LPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPL
Sbjct: 251 LPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPL 310

Query: 361 VKIWHEIRTNGPKKGGGSK 379
           VKIWHEIRTNGPKKGGGSK
Sbjct: 311 VKIWHEIRTNGPKKGGGSK 329


>gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens]
          Length = 590

 Score = 35.0 bits (79), Expect = 0.11
 Identities = 48/187 (25%), Positives = 82/187 (43%), Gaps = 30/187 (16%)

Query: 169 VTGIIA-----ANVLVFCLWRVPSLQRTMIRYFTSNPASKVLC----SPMLLSTF---SH 216
           +TGI+A      N+LV   ++V    +T+  YF  + A   L     S  L +T+   + 
Sbjct: 74  LTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNR 133

Query: 217 FSLFHMAANMYVLWSF---SSSIVNILGQEQFMAVYLSAGVISNFVSYVGKVATGRYGPS 273
           ++L ++A ++++   +   ++S++N+L        Y S   I+  ++Y  K  T R G  
Sbjct: 134 WALGNLACDLWLAIDYVASNASVMNLLVIS--FDRYFS---ITRPLTYRAKRTTKRAGVM 188

Query: 274 LGASGAIMTVLAAVCT----------KIPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGM 323
           +G +  I  VL A              +P G   I FL   T T G A+ A     T   
Sbjct: 189 IGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMT 248

Query: 324 ILGWKFF 330
           IL W+ +
Sbjct: 249 ILYWRIY 255


>gi|190341097 rhomboid family 1 [Homo sapiens]
          Length = 855

 Score = 34.7 bits (78), Expect = 0.15
 Identities = 31/154 (20%), Positives = 67/154 (43%), Gaps = 17/154 (11%)

Query: 211 LSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYVGKVATGRY 270
           LS F H  + H   ++    +    +  + G  +   +YL +GV  N  S +       Y
Sbjct: 658 LSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFL----PY 713

Query: 271 GPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFF 330
              +G +G+   +LA +  ++ +    I+  P   F     L  ++ + T G++    + 
Sbjct: 714 RAEVGPAGSQFGILACLFVELFQS-WQILARPWRAFF--KLLAVVLFLFTFGLL---PWI 767

Query: 331 DHAAHLGGALFGIW-------YVTYGHELIWKNR 357
           D+ AH+ G + G++       Y+++G   +++ R
Sbjct: 768 DNFAHISGFISGLFLSFAFLPYISFGKFDLYRKR 801


>gi|10863903 thyroid hormone receptor interactor 12 [Homo sapiens]
          Length = 1992

 Score = 30.0 bits (66), Expect = 3.6
 Identities = 20/57 (35%), Positives = 27/57 (47%), Gaps = 2/57 (3%)

Query: 7  AQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKVEPR 63
          +QR     Q    S+GGRSC   +AV+ P      R N   +QK G  + P+K   R
Sbjct: 16 SQRNTAGAQPQDDSIGGRSCSSSSAVIVPQPEDPDRANTSERQKTG--QVPKKDNSR 70


>gi|210147475 zinc finger protein 92 homolog [Homo sapiens]
          Length = 416

 Score = 29.6 bits (65), Expect = 4.7
 Identities = 19/54 (35%), Positives = 24/54 (44%), Gaps = 2/54 (3%)

Query: 40  GRRFNFFIQQKCGFRKAPRKVEPRR--SDPGTSGEAYKRSALIPPVEETVFYPS 91
           GRR N F  Q     + P K E  R  + PG++G     +A  PP   T   PS
Sbjct: 358 GRRANLFKHQAVHGARRPAKAETARRLAGPGSTGPGSAVAATSPPRPSTAARPS 411


>gi|148839292 ATPase type 13A3 [Homo sapiens]
          Length = 1226

 Score = 28.9 bits (63), Expect = 8.0
 Identities = 20/71 (28%), Positives = 35/71 (49%), Gaps = 6/71 (8%)

Query: 296  LAIIFLPMFTFTAGNALKAIIAM-DTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIW 354
            LAII + +FT +   A K ++A    +G+I G   F   + L   +  I + + G    W
Sbjct: 973  LAIILVVVFTMSLNPAWKELVAQRPPSGLISGALLF---SVLSQIIICIGFQSLG--FFW 1027

Query: 355  KNREPLVKIWH 365
              ++P  ++WH
Sbjct: 1028 VKQQPWYEVWH 1038


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.138    0.451 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,184,572
Number of Sequences: 37866
Number of extensions: 661263
Number of successful extensions: 1827
Number of sequences better than 10.0: 7
Number of HSP's better than 10.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1822
Number of HSP's gapped (non-prelim): 8
length of query: 379
length of database: 18,247,518
effective HSP length: 104
effective length of query: 275
effective length of database: 14,309,454
effective search space: 3935099850
effective search space used: 3935099850
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.