Search of human proteins with 10947061

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
         (1115 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]             2222   0.0  
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]             2198   0.0  
gi|34486092 adenylate cyclase 5 [Homo sapiens]                       1424   0.0  
gi|4557257 adenylate cyclase 8 [Homo sapiens]                         736   0.0  
gi|31083193 adenylate cyclase 1 [Homo sapiens]                        727   0.0  
gi|115387102 adenylate cyclase 2 [Homo sapiens]                       677   0.0  
gi|24497587 adenylate cyclase 4 [Homo sapiens]                        643   0.0  
gi|4557255 adenylate cyclase 7 [Homo sapiens]                         638   0.0  
gi|148536830 adenylate cyclase 3 [Homo sapiens]                       619   e-177
gi|50959205 adenylate cyclase 9 [Homo sapiens]                        216   7e-56
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom...   119   2e-26
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]    119   2e-26
gi|134152694 guanylate cyclase 2F [Homo sapiens]                      118   3e-26
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]            117   8e-26
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]       114   4e-25
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho...   109   2e-23
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho...   109   2e-23
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho...   109   2e-23
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom...   109   2e-23
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho...   109   2e-23
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho...   108   4e-23
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]        105   3e-22
gi|222080083 guanylate cyclase 2C [Homo sapiens]                      100   8e-21
gi|225579067 solute carrier family 12, member 4 isoform e [Homo ...    37   0.080
gi|225579065 solute carrier family 12, member 4 isoform d [Homo ...    37   0.080
gi|225579061 solute carrier family 12, member 4 isoform b [Homo ...    37   0.080
gi|4827006 solute carrier family 12, member 4 isoform a [Homo sa...    37   0.080
gi|225579063 solute carrier family 12, member 4 isoform c [Homo ...    36   0.23 
gi|239754370 PREDICTED: hypothetical protein [Homo sapiens]            35   0.40 
gi|239748924 PREDICTED: hypothetical protein [Homo sapiens]            35   0.40 

>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
          Length = 1115

 Score = 2222 bits (5759), Expect = 0.0
 Identities = 1115/1115 (100%), Positives = 1115/1115 (100%)

Query: 1    MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP 60
            MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
Sbjct: 1    MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP 60

Query: 61   PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR 120
            PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
Sbjct: 61   PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR 120

Query: 121  RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY 180
            RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
Sbjct: 121  RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY 180

Query: 181  VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW 240
            VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
Sbjct: 181  VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW 240

Query: 241  CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN 300
            CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
Sbjct: 241  CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN 300

Query: 301  VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT 360
            VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
Sbjct: 301  VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT 360

Query: 361  KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC 420
            KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
Sbjct: 361  KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC 420

Query: 421  LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV 480
            LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
Sbjct: 421  LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV 480

Query: 481  HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA 540
            HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
Sbjct: 481  HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA 540

Query: 541  YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR 600
            YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
Sbjct: 541  YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR 600

Query: 601  QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK 660
            QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
Sbjct: 601  QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK 660

Query: 661  YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC 720
            YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
Sbjct: 661  YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC 720

Query: 721  GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLASSVFLHI 780
            GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLASSVFLHI
Sbjct: 721  GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLASSVFLHI 780

Query: 781  SSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVA 840
            SSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVA
Sbjct: 781  SSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVA 840

Query: 841  LKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILP 900
            LKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILP
Sbjct: 841  LKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILP 900

Query: 901  KDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIA 960
            KDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIA
Sbjct: 901  KDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIA 960

Query: 961  DFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHI 1020
            DFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHI
Sbjct: 961  DFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHI 1020

Query: 1021 NEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLY 1080
            NEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLY
Sbjct: 1021 NEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLY 1080

Query: 1081 QVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS 1115
            QVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS
Sbjct: 1081 QVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS 1115


>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
          Length = 1168

 Score = 2198 bits (5695), Expect = 0.0
 Identities = 1115/1168 (95%), Positives = 1115/1168 (95%), Gaps = 53/1168 (4%)

Query: 1    MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP 60
            MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
Sbjct: 1    MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP 60

Query: 61   PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR 120
            PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
Sbjct: 61   PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR 120

Query: 121  RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY 180
            RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
Sbjct: 121  RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY 180

Query: 181  VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW 240
            VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
Sbjct: 181  VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW 240

Query: 241  CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN 300
            CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
Sbjct: 241  CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN 300

Query: 301  VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT 360
            VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
Sbjct: 301  VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT 360

Query: 361  KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC 420
            KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
Sbjct: 361  KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC 420

Query: 421  LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV 480
            LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
Sbjct: 421  LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV 480

Query: 481  HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA 540
            HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
Sbjct: 481  HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA 540

Query: 541  YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR 600
            YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
Sbjct: 541  YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR 600

Query: 601  QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK 660
            QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
Sbjct: 601  QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK 660

Query: 661  YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC 720
            YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
Sbjct: 661  YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC 720

Query: 721  GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANM------------------- 761
            GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANM                   
Sbjct: 721  GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLT 780

Query: 762  ----------------------------------YFIGNMLLSLLASSVFLHISSIGKLA 787
                                              YFIGNMLLSLLASSVFLHISSIGKLA
Sbjct: 781  PADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA 840

Query: 788  MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV 847
            MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
Sbjct: 841  MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV 900

Query: 848  ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF 907
            ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF
Sbjct: 901  ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF 960

Query: 908  LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS 967
            LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS
Sbjct: 961  LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS 1020

Query: 968  EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN 1027
            EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
Sbjct: 1021 EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN 1080

Query: 1028 FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG 1087
            FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG
Sbjct: 1081 FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG 1140

Query: 1088 YQLECRGVVKVKGKGEMTTYFLNGGPSS 1115
            YQLECRGVVKVKGKGEMTTYFLNGGPSS
Sbjct: 1141 YQLECRGVVKVKGKGEMTTYFLNGGPSS 1168


>gi|34486092 adenylate cyclase 5 [Homo sapiens]
          Length = 1261

 Score = 1424 bits (3687), Expect = 0.0
 Identities = 765/1165 (65%), Positives = 871/1165 (74%), Gaps = 73/1165 (6%)

Query: 16   KTAWGERNGQ-----KRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAF 70
            K+AW ER G       R +RRG  +GG            +   + +  G    P   +  
Sbjct: 100  KSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVG 159

Query: 71   I--RRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQS 128
            +  RRG      EL   AV  G    +  ++A   +   P AV   G +C   L+Q+F+S
Sbjct: 160  LEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLG-ACCLALLQIFRS 218

Query: 129  KQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAYVALLACAA 188
            K+F S KLERLYQRYFF++NQSSLT+LMAVLVL+  V+LAFHAA    Q  Y+A+LA A 
Sbjct: 219  KKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAV 278

Query: 189  ALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYI 248
             + + + V+CNR +F QD M +  Y ++ ++ AVQV G L   PRS S G+W  VFF+Y 
Sbjct: 279  GVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYT 338

Query: 249  AYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHY 308
             YTLLP+RMRAAVLSG+ LS LHL +A + N  D FL KQL +NVL+F CTN++G+CTHY
Sbjct: 339  IYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHY 398

Query: 309  PAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFH 368
            PAEVSQRQAFQETR  IQARLH Q EN+QQERLLLSVLP+HVAMEMK DIN K+EDMMFH
Sbjct: 399  PAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFH 458

Query: 369  KIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGD 428
            KIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGD
Sbjct: 459  KIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGD 518

Query: 429  CYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR 488
            CYYCVSGLPEARADHAHCCVEMG+DMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR
Sbjct: 519  CYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR 578

Query: 489  KWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIE 548
            KWQFDVWSNDVTLANHMEAGG+AGRIHIT+ATL YLNGDYEVEPG GGERNAYLKE  IE
Sbjct: 579  KWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIE 638

Query: 549  TFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAF----SRTKDSKAFRQMGI 604
            TFLIL  +QKRKEEKAM+AK+ R R NS+    P W  +R F       + SK  ++MG 
Sbjct: 639  TFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGF 698

Query: 605  DDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRK 664
            +D    N   Q++ NPEDEVDEFL RAIDARSID+LR +HVR+FLLTF+  DLEKKYS++
Sbjct: 699  EDPKDKN--AQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQ 756

Query: 665  VDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLF 724
            VD RFGAYVACA LVF FICF+Q+ I PHS  ML  Y +  LLL + V +  +YSC  LF
Sbjct: 757  VDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLF 816

Query: 725  PKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNM-LLSLLAS--------- 774
            P  LQ LSR IVRS+ +ST VG+F++ LVF +A  NM+   +  LL  LA          
Sbjct: 817  PSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQV 876

Query: 775  ------------------------------------SVFL---------HISSIGKLAMI 789
                                                SV L          IS IGKL ++
Sbjct: 877  NACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLM 936

Query: 790  FVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPA-AGRVALKYMTPVI 848
              + LIY VL++  P  T+FDN DLL+  + +   N       CP  A +VALK +TP+I
Sbjct: 937  LAIELIY-VLIVEVPGVTLFDNADLLVTANAIDFFNNGTS--QCPEHATKVALKVVTPII 993

Query: 849  LLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFL 908
            + VF LALYLHAQQVESTARLDFLWKLQAT EKEEMEELQAYNRRLLHNILPKDVAAHFL
Sbjct: 994  ISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFL 1053

Query: 909  ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE 968
            ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE
Sbjct: 1054 ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE 1113

Query: 969  ERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNF 1028
            +RFRQLEKIKTIGSTYMAASGLN STYD+VG++HI ALAD+AM+LM+QMK+INEHSFNNF
Sbjct: 1114 DRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNF 1173

Query: 1029 QMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGY 1088
            QMKIGLN+GPVVAGVIGARKPQYDIWGNTVNV+SRMDSTGVPDRIQVTTD+YQVLAA  Y
Sbjct: 1174 QMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTY 1233

Query: 1089 QLECRGVVKVKGKGEMTTYFLNGGP 1113
            QLECRGVVKVKGKGEM TYFLNGGP
Sbjct: 1234 QLECRGVVKVKGKGEMMTYFLNGGP 1258


>gi|4557257 adenylate cyclase 8 [Homo sapiens]
          Length = 1251

 Score =  736 bits (1901), Expect = 0.0
 Identities = 438/1055 (41%), Positives = 623/1055 (59%), Gaps = 83/1055 (7%)

Query: 114  SGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFH--- 170
            +G   +R ++       F+S  LERLYQRYF    + S  ++  + VL    LL  H   
Sbjct: 144  NGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSL 203

Query: 171  -AAPARPQPAYVALLACAAALFVGLMVVCNR----HSFRQDSMWVVSYVVLGILAAVQVG 225
             +AP  P    +        + +  +VV  +    H++ Q S  V    +   + A  +G
Sbjct: 204  ASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLG 263

Query: 226  GALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFL 285
              L  D      G+   +F ++  Y++LP+ +  A+L+GLG S L +IL   + R     
Sbjct: 264  YGLLGD------GIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVIS 317

Query: 286  WKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSV 345
              Q+ A  +LF+C N  GI   Y ++ +QRQAF ETR  ++ARL L+ EN++QERL+LSV
Sbjct: 318  INQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSV 377

Query: 346  LPQHVAMEMKEDINTKKEDMM---FHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVM 402
            LP+ V +EM  D+   +++ +   FH+IYI +++NVSILFAD++GFT+L++  +AQELV 
Sbjct: 378  LPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVR 437

Query: 403  TLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVR 462
             LNELFARFD+LA E+HCLRIKILGDCYYCVSGLPE R DHAHCCVEMG+ MI+ I  VR
Sbjct: 438  MLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVR 497

Query: 463  EVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQ 522
              T  +V+MR+GIHSG V CGVLGLRKWQFDVWS DV +AN +E+GG  GRIHI++ATL 
Sbjct: 498  SRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLD 557

Query: 523  YLNGDYEVEPGRGGERNAYLKEQHIETFLI-------LGASQKRKEEKAMLAKLQRTRAN 575
             LNGDY VE G G ERN +L++ +IET+LI       L   +   +E    +  + + A 
Sbjct: 558  CLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGAT 617

Query: 576  SMEGLMPRWVP-DRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDA 634
              EG     +P D    +     A  +  I+             +  +E+++ +   ID 
Sbjct: 618  FTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDL 677

Query: 635  RSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHS 694
            RS D+LR++H++ F L F+   LE KYS+  D  F + + CA +V  FI  IQ L+    
Sbjct: 678  RSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSR 737

Query: 695  TLMLGIYASIFLLL---LITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVL 751
             + + I  SI ++L   L+ +     Y C    P  L++    I  +      +   S+L
Sbjct: 738  VMPMTIQFSILIMLHSALVLITTAEDYKC---LPLILRKTCCWINETYLARNVIIFASIL 794

Query: 752  LVFTSAIANM------------------------------YFIGNMLLSLLASSVFLHIS 781
            + F  AI N+                              YF+   +L+++  +VFL ++
Sbjct: 795  INFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLN 854

Query: 782  SIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVAL 841
            S+ KLA++ ++  IY  LL     A +F  YD       L  S E F G           
Sbjct: 855  SVLKLAVLLIMIAIY-ALLTETVYAGLFLRYD------NLNHSGEDFLG----------T 897

Query: 842  KYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPK 901
            K ++ +++ +F LA++ H QQ+E TARLDFLW++QA  E  EM+EL+ +N  +L NILP 
Sbjct: 898  KEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPS 957

Query: 902  DVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIAD 961
             VA HFL ++R N+ELY QS + V VMFASI  F++FY + E NN+GVECLRLLNEIIAD
Sbjct: 958  HVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIAD 1017

Query: 962  FDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGR-SHITALADYAMRLMEQMKHI 1020
            FDE++ E+RF+ +EKIKTIGSTYMA SGL+        +  H+ ALAD+++ L E ++ I
Sbjct: 1018 FDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEI 1077

Query: 1021 NEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLY 1080
            N+HSFNNF+++IG++ G VVAGVIGA+KPQYDIWG TVN++SRMDSTGV  RIQV  + Y
Sbjct: 1078 NKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETY 1137

Query: 1081 QVLAAKGYQLECRGVVKVKG----KGEMTTYFLNG 1111
             +L  +G+  + RG + VKG    +G++ TYFL G
Sbjct: 1138 LILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLG 1172


>gi|31083193 adenylate cyclase 1 [Homo sapiens]
          Length = 1119

 Score =  727 bits (1877), Expect = 0.0
 Identities = 444/1061 (41%), Positives = 620/1061 (58%), Gaps = 65/1061 (6%)

Query: 101  GGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLV 160
            GG     P    R+  +  RR ++    ++F   +LE L++ Y  ++ Q++    +AVL 
Sbjct: 11   GGGGAGEPGGAERAAGTSRRRGLRACD-EEFACPELEALFRGYTLRLEQAATLKALAVLS 69

Query: 161  LLTAVL-LAFHAAPARPQPAYV-ALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLG- 217
            LL   L LA       P P            LF+ L+VV N  S +   +  V  + L  
Sbjct: 70   LLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQQVGQLALLF 129

Query: 218  ------ILAAVQVGG------ALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGL 265
                  +     +GG        A  P +   G+W  +   +++Y LLP+R   A+  GL
Sbjct: 130  SLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVRSLLAIGFGL 189

Query: 266  GLSTLHLILAWQLNRGDA-FLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGY 324
             ++  HL++   L       LW+ LGAN LLF+  N+ G+      E SQR+AF + R  
Sbjct: 190  VVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVRILTERSQRKAFLQARSC 249

Query: 325  IQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFAD 384
            I+ RL L+ EN +QERLL+S+LP++VAMEMKED   K  + +FHKIYIQ+HDNVSILFAD
Sbjct: 250  IEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDF-LKPPERIFHKIYIQRHDNVSILFAD 308

Query: 385  IEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHA 444
            I GFT LASQCTAQELV  LNELF +FD+LA ENHC RIKILGDCYYCVSGL + + DHA
Sbjct: 309  IVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHA 368

Query: 445  HCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANH 504
            HCCVEMG+DMI+ I+ V E T V++NMRVG+H+GRV CGVLGLRKWQ+DVWSNDVTLAN 
Sbjct: 369  HCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANV 428

Query: 505  MEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKA 564
            MEA G  G++HIT+ TL  LNGDYEVEPG G ERN++LK  +IETF I+ + +++     
Sbjct: 429  MEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIVPSHRRKIFPGL 488

Query: 565  MLAKLQRTRANSMEG-------------LMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDN 611
            +L+ ++  +    +              +    +P       +D    R +        N
Sbjct: 489  ILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRN 548

Query: 612  RGTQDA----LNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDP 667
            R +         P   V+ ++SR ++AR  + L    +  F L ++  + E+KY +  D 
Sbjct: 549  RSSFSTNVVYTTPGTRVNRYISRLLEARQTE-LEMADLNFFTLKYKHVEREQKYHQLQDE 607

Query: 668  RFGAYVACALLVFCFICFIQLLIFPHST--LMLGIYASIFLLLLITVLICAVYSCGSLFP 725
             F + V   L++      + LLIFP S   L+L ++   FL+  +  L      C   FP
Sbjct: 608  YFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRVQC---FP 664

Query: 726  KALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLASSVFLHISSIGK 785
              L    R         T + IF V+L+++ A   +        S   +S  + +SS G+
Sbjct: 665  GCLTIQIR---------TVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLSSGGQ 715

Query: 786  LAMIFVLGLIY----LVLLLLGP-PATIF---DNYDLLLGVHGLASSNET---FDGLDCP 834
               +  L        L+  L+G  P  IF    +   ++ + GL +S        G    
Sbjct: 716  RTALPTLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTSYILVLELSGYTRT 775

Query: 835  AAGRVALKYMTPVI-LLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRR 893
              G V+ +   P++ +L+F+ AL LHA+QV+   RLD+LW  QA  E+E+ME+++  NRR
Sbjct: 776  GGGAVSGRSYEPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRR 835

Query: 894  LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLR 953
            +L N+LP  VA HFL    RN +LYYQS   V VMFASI NF++FY+EL+ NN GVECLR
Sbjct: 836  ILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLR 895

Query: 954  LLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGR---SHITALADYA 1010
            LLNEIIADFDE++ ++ ++ +EKIKTIGSTYMAA GL  ++  +  +   SH++ LAD+A
Sbjct: 896  LLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFA 955

Query: 1011 MRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVP 1070
            + + + +  IN  S+N+F +++G+N+GPVVAGVIGAR+PQYDIWGNTVNV+SRMDSTGV 
Sbjct: 956  IEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQ 1015

Query: 1071 DRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNG 1111
             RIQVT +++++L    Y   CRG V VKGKGEM TYFL G
Sbjct: 1016 GRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEG 1056


>gi|115387102 adenylate cyclase 2 [Homo sapiens]
          Length = 1091

 Score =  677 bits (1748), Expect = 0.0
 Identities = 409/1061 (38%), Positives = 613/1061 (57%), Gaps = 105/1061 (9%)

Query: 139  LYQRYFFQMNQSSLTLLMAVLVL--LTAVLLAFHAAPARPQP--AYVALLACAAALFVGL 194
            LY+ Y+    Q  L + + ++V+    A+L  F A     +   A++  +  A A+F  +
Sbjct: 33   LYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAI 92

Query: 195  MVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLP 254
             ++    S  +  + + S V+   L A+           SP   +   +F +++ YT+LP
Sbjct: 93   FILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLP 152

Query: 255  IRMRAAVLSGLGLSTLH-LILAWQLNR---GDAFLWKQLGANVLLFLCTNVIGICTHYPA 310
              MR A+++ +  S+ H ++L+  L+    G   L  Q+ ANV++F+C N+ G    +  
Sbjct: 153  FNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLM 212

Query: 311  EVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTK----KEDMM 366
            E++ +Q +Q+T   I++R+ L+ E RQQERLLLS+LP H+AMEMK +I  +    K   M
Sbjct: 213  ELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQM 272

Query: 367  -----FHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCL 421
                 FH +Y+++H NVSIL+ADI GFT LAS C+  ELV  LNELF +FD++A EN C+
Sbjct: 273  ENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECM 332

Query: 422  RIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVH 481
            RIKILGDCYYCVSGLP +  +HA  CV+MG+DM EAI  VR+ TGV++NMRVG+HSG V 
Sbjct: 333  RIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVL 392

Query: 482  CGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAY 541
            CGV+GL+KWQ+DVWS+DVTLANHMEAGG  GR+HI+  TL++LNG Y+VE G G  R+ Y
Sbjct: 393  CGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPY 452

Query: 542  LKEQHIETFLILGASQKRKEEKAMLAKLQ-----RTRAN-SMEGLMPRWVPDRAFSRT-- 593
            LK+  ++T+ ++    +R+  + +          + RA+  M   +  W   + F+    
Sbjct: 453  LKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHH 512

Query: 594  KDSKAFRQMGIDDS----------SKDNRGTQDALNPEDEVDEFLSRAIDARSIDQ--LR 641
            +DS       I  +          ++  R        E+E++E + +AID  +  +  L+
Sbjct: 513  RDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLK 572

Query: 642  KDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIY 701
             + ++R  L F  + LEK+Y     P F  YV CA L+F  I  +Q+L+ P ++++   +
Sbjct: 573  SEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISF 632

Query: 702  ASIFLLLLITVLIC---AVYSCGSLFPKALQRLSRS--IVRSRA-HSTAVGIFSVLLVFT 755
             + FLLL   + +C    +  C       L  L +S  I+ +R     ++ I +  ++  
Sbjct: 633  GAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILM 692

Query: 756  SAIANM----------------------------------------YFIGNMLLSLLASS 775
             A+ NM                                        YFI + +L L++ S
Sbjct: 693  MAVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCS 752

Query: 776  VFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPA 835
            VFL ++   K+ +I ++ L+    +LL   A +  +Y  +L               + P 
Sbjct: 753  VFLRVNYELKM-LIMMVALVGYNTILLHTHAHVLGDYSQVL--------------FERPG 797

Query: 836  AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLL 895
              +  LK M  V L +F + L +  +Q E   RLDFLWK +   E+EE+E ++  NR LL
Sbjct: 798  IWK-DLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLL 856

Query: 896  HNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLL 955
             N+LP  VA HFLAR  +N+ELY+QS +CV VMFASI +F EFY E + N EG+ECLRLL
Sbjct: 857  ENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLL 916

Query: 956  NEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRS------HITALADY 1009
            NEIIADFD+++S+ +F  +EKIKTIGSTYMAA+GL+A    +  +       HI  + ++
Sbjct: 917  NEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEF 976

Query: 1010 AMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGV 1069
            A  L+ ++  IN+HSFN+F++++G+N GPV+AGVIGA+KPQYDIWGNTVNV+SRMDSTGV
Sbjct: 977  AFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGV 1036

Query: 1070 PDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLN 1110
             D+IQVT +   VL   GY   CRG++ VKGKG++ TYF+N
Sbjct: 1037 LDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVN 1077


>gi|24497587 adenylate cyclase 4 [Homo sapiens]
          Length = 1077

 Score =  643 bits (1659), Expect = 0.0
 Identities = 417/1061 (39%), Positives = 581/1061 (54%), Gaps = 104/1061 (9%)

Query: 140  YQRYFFQMNQSSLTLLMAVLVLLT-AVLLAFHAAPARP---QPAYVALLACAAALFVGLM 195
            Y+ Y+    Q  L LL+  +VL   A LLA   A  R     P+++  + CA   F  L+
Sbjct: 17   YETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLCALGGFSLLL 76

Query: 196  VVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPV----FFVYIAYT 251
             + +R    Q   W      L  +A + +G A        SA  W  V    F ++ AY 
Sbjct: 77   GLASREQRLQ--RWTRPLSGLVWVALLALGHAFLFTGGVVSA--WDQVSYFLFVIFTAYA 132

Query: 252  LLPIRMRAAVLSGLGLSTLHLI-----LAWQLNRGDAFLWKQLGANVLLFLCTNVIGICT 306
            +LP+ MR A ++GL  S  HL+     L  Q +   A L  QL AN +LFLC NV G+  
Sbjct: 133  MLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALL-PQLAANAVLFLCGNVAGVYH 191

Query: 307  HYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTK----- 361
                E + R  F+E    + +R  L  E + QE LLLS+LP ++A EMK +I  +     
Sbjct: 192  KALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQ 251

Query: 362  ----KEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAE 417
                +    FH +Y+++H  VS+L+ADI GFT LAS+C+ +ELV+ LNELF +FD++A E
Sbjct: 252  GSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKE 311

Query: 418  NHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHS 477
            + C+RIKILGDCYYCVSGLP +  DHA  CV MG+DM  AI  +R  TGV++NMRVG+HS
Sbjct: 312  HECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHS 371

Query: 478  GRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGE 537
            G V CGV+GL+KWQ+DVWS+DVTLANHMEAGG  GR+HIT ATL  L G Y VE      
Sbjct: 372  GSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGMEH 431

Query: 538  RNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPR-----------WVP 586
            R+ YL+E    T+L++    + ++EK     L     +S+EGL  R           W  
Sbjct: 432  RDPYLRELGEPTYLVIDPRAEEEDEKGTAGGL----LSSLEGLKMRPSLLMTRYLESWGA 487

Query: 587  DRAFSR---------------TKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRA 631
             + F+                 K   +F      D S+  RG  D L+  D     +   
Sbjct: 488  AKPFAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRTPRGLDDELDTGDAKFFQVIEQ 547

Query: 632  IDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIF 691
            ++++   +  KD      L F+ +++EK+Y     P F  Y AC  LVF     IQ+L+ 
Sbjct: 548  LNSQKQWKQSKD-FNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQMLVT 606

Query: 692  PHSTLMLGIYASIFLLLLITVLIC---AVYSCGSLFPKALQ---RLSRSIVRSRAHSTAV 745
                 +   Y+  FLL L+ + +C    +  C    PK L     LS  +        A+
Sbjct: 607  NRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRPGLRIAL 666

Query: 746  GIFSVLLVFTSAIANMYF-------------IGNML----------LSLLASSVFLHISS 782
            G  ++LLVF  AI +++F             + +M+          L L++    +H  +
Sbjct: 667  GTATILLVFAMAITSLFFFPTSSDCPFQAPNVSSMISNLSWELPGSLPLISVPYSMHCCT 726

Query: 783  IGKLAMIFVLGLIY---LVLLLLGPPATIFDNYDLLLGVHGLASS----NETFDGLDCPA 835
            +G L+    L + +   L+LLLL   A+      L L  H   S           LD   
Sbjct: 727  LGFLSCSLFLHMSFELKLLLLLLWLAASC----SLFLHSHAWLSECLIVRLYLGPLDSRP 782

Query: 836  AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLL 895
                  K M  +   +F   L + A+Q E   RLDFLWK +   E+EE E ++   R LL
Sbjct: 783  GVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLL 842

Query: 896  HNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLL 955
             N+LP  VA  F+ + RRN++LY+QS ECV V+FAS+ +F EFY E   N+EG+ECLRLL
Sbjct: 843  ENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLL 902

Query: 956  NEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGR------SHITALADY 1009
            NEIIADFDE++S+ +F  +EKIKTIGSTYMAA+GLNA++     +      SH+  + ++
Sbjct: 903  NEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEF 962

Query: 1010 AMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGV 1069
            A+ L  ++  IN+HSFNNF++++GLN GPVVAGVIGA+KPQYDIWGNTVNV+SRM+STGV
Sbjct: 963  AVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGV 1022

Query: 1070 PDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLN 1110
              +IQVT +    L + GY    RGV+KVKGKG++ TYFLN
Sbjct: 1023 LGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLN 1063


>gi|4557255 adenylate cyclase 7 [Homo sapiens]
          Length = 1080

 Score =  638 bits (1646), Expect = 0.0
 Identities = 406/1064 (38%), Positives = 580/1064 (54%), Gaps = 106/1064 (9%)

Query: 137  ERLYQRYFFQMNQSSLTL---LMAVLVLLTAVLLAFHAAPARPQPAYVALLACAAALFVG 193
            + LY++Y        L L   L+A    +  +++AF         A + +     A+F  
Sbjct: 19   DALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRHQAILGMAFLVLAVFAA 78

Query: 194  LMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPV----FFVYIA 249
            L V+       +   W+ +  +L     V +G  L  D  + +A  W  V    F V++ 
Sbjct: 79   LSVLMYVECLLR--RWLRALALLTWACLVALGYVLVFDAWTKAACAWEQVPFFLFIVFVV 136

Query: 250  YTLLPIRMRAAVLSGLGLSTLHLILAWQLNRG----DAFLWKQLGANVLLFLCTNVIGIC 305
            YTLLP  MR AV  G   +  HL++   L  G       +  QL AN ++FLC N+ G  
Sbjct: 137  YTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQLLANAVIFLCGNLTGAF 196

Query: 306  THYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKE-- 363
              +  + + R  F  T   IQ R  L+ E RQQE LLLSVLP H++M MK  I  + +  
Sbjct: 197  HKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEH 256

Query: 364  -------DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAA 416
                   D  FH +Y+++H NVSIL+ADI GFT LAS C+ +ELV+ LNELF +FD++A 
Sbjct: 257  GDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAK 316

Query: 417  ENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIH 476
             N C+RIKILGDCYYCVSGLP +   HA  CV+MG+DM +AI  VRE TGV++NMRVGIH
Sbjct: 317  ANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIH 376

Query: 477  SGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGG 536
            SG V CGV+GLRKWQ+DVWS+DV+LAN MEA G  GR+HIT ATL++L+  YEVE G G 
Sbjct: 377  SGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQ 436

Query: 537  ERNAYLKEQHIETFLILGASQKRKEEKAML-------AKLQRTRANSMEGLMPRWVPDRA 589
            +R+ YLKE +I T+L++    ++    +         A L+   +  M   +  W   R 
Sbjct: 437  QRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYLESWGAARP 496

Query: 590  FS------------------RTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRA 631
            F+                  R   S   R     D S   +G  +    +D  D+ +  A
Sbjct: 497  FAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSE----DDSYDDEMLSA 552

Query: 632  IDARSIDQ---LRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQL 688
            I+  S  +    + D    F   F  +  E++Y     PR     ACA L+F  I  + +
Sbjct: 553  IEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVCILLVHV 612

Query: 689  LIFPHSTLM---LGIYASIFLLLL-----------------------------ITVLICA 716
            L+ P +  +    G+ A +  L+L                             +  L  A
Sbjct: 613  LLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISERVETQPLLRLTLA 672

Query: 717  VYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANM-----YFIGNMLLSL 771
            V + GSL   A+  ++  ++  +     VG  + LL  +S    +     Y+  + +L  
Sbjct: 673  VLTIGSLLTVAI--INLPLMPFQVPELPVGNETGLLAASSKTRALCEPLPYYTCSCVLGF 730

Query: 772  LASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLL-LGVHGLASSNETFDG 830
            +A SVFL +S   K+ ++ V  + YLVL  L P       +D    G+  L   N T  G
Sbjct: 731  IACSVFLRMSLEPKVVLLTVALVAYLVLFNLSP----CWQWDCCGQGLGNLTKPNGTTSG 786

Query: 831  LDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAY 890
               P+     LK MT   L++F + L   ++Q++   RLD LWK +   E EE E ++  
Sbjct: 787  --TPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFETMENV 844

Query: 891  NRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVE 950
            NR LL N+LP  VAAHF+  ++ N++ Y+QS +CV VMFAS+ +F  FY E + N EG+E
Sbjct: 845  NRLLLENVLPAHVAAHFIG-DKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLE 903

Query: 951  CLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLN-ASTYD----QVGRSHITA 1005
            CLRLLNEIIADFDE++ + +F  +EKIKTIGSTYMAA+GL+ AS ++    +   +HI  
Sbjct: 904  CLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGV 963

Query: 1006 LADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMD 1065
            + ++++ LM ++  IN HSFN+F++++G+N GPV+AGVIGARKPQYDIWGNTVNV+SRM+
Sbjct: 964  MVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRME 1023

Query: 1066 STGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFL 1109
            STG   +IQVT +   +L   GY  ECRG++ VKGKGE+ TYF+
Sbjct: 1024 STGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFV 1067


>gi|148536830 adenylate cyclase 3 [Homo sapiens]
          Length = 1144

 Score =  619 bits (1597), Expect = e-177
 Identities = 398/1080 (36%), Positives = 596/1080 (55%), Gaps = 104/1080 (9%)

Query: 126  FQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAP-ARPQPAYVALL 184
            F    F    LE LYQ YF +    +L +L+    L    ++   A   +  + A +A+ 
Sbjct: 52   FMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVA 111

Query: 185  ACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALA---ADPRSPSAGLWC 241
                 L + L V+C +          V   VL +L   Q+   L    A   + S  +  
Sbjct: 112  GIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGW 171

Query: 242  PVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAW-------QLNRGDAFLWKQLGANVL 294
             VFFV+  +  LP+ +   V+  +    +H ++         Q       L +++ ANV 
Sbjct: 172  QVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVF 231

Query: 295  LFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEM 354
            L+LC   +GI ++Y A+   R+AF E R  ++ +++L+ +++QQE L+LS+LP+HVA EM
Sbjct: 232  LYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEM 291

Query: 355  KEDIN---TKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARF 411
             +D+    ++K+   F+ +Y+ +H+NVSILFADI GFT L+S C+AQELV  LNELFARF
Sbjct: 292  LKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARF 351

Query: 412  DKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNM 471
            DKLAA+ H LRIKILGDCYYC+ GLP+ R DHA C + MG+ M+EAIS VRE T   V+M
Sbjct: 352  DKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDM 411

Query: 472  RVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVE 531
            RVG+H+G V  GVLG ++WQ+DVWS DVT+AN MEAGG  GR+HI+++T+  L G+++VE
Sbjct: 412  RVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVE 471

Query: 532  PGRGGERNAYLKEQHIETFLILG--------ASQKRKEEKAMLAKLQRTRANSMEGLMPR 583
            PG GG R  YL+E+ IET+LI+         A+Q      A+      +  +S   L+  
Sbjct: 472  PGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIET 531

Query: 584  WVPD---RAFSRTKDSKAFRQMGIDDSSKDNRGTQ-----------DALNPEDEVDEFLS 629
              P+    +   T +    +    D+ S  N   +           DA   E E+++ L+
Sbjct: 532  KEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLN 591

Query: 630  RAIDARSIDQLRKDHVRRFLLT--FQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQ 687
             A+  R   Q+ K     FLL+  F   ++E +YS + + + GA  +C+ +V      ++
Sbjct: 592  EALLERESAQVVKKR-NTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVE 650

Query: 688  LLIFP-----HSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSR--- 739
            +LI P     + T M+G    I LL+L    + A++     FPK L   S  I R+R   
Sbjct: 651  ILIDPWLMTNYVTFMVG---EILLLILTICSLAAIFP--RAFPKKLVAFSTWIDRTRWAR 705

Query: 740  -----------AHSTAVGIFSVLLVFT---SAIANMYFIGNML-----------LSLLAS 774
                         +  V + S L  +T   +A A M   G+ L           LSL+A+
Sbjct: 706  NTWAMLAIFILVMANVVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIAT 765

Query: 775  SVFLHISSIGKLA-MIFVLGLIYLVLLLLGPPATIFDNYD---------LLLGVHGLASS 824
             + + +S + KL  M+ V G +  + L    P  +FD YD          ++ +  +   
Sbjct: 766  IMLVQVSHMVKLTLMLLVAGAVATINLYAWRP--VFDEYDHKRFREHDLPMVALEQMQGF 823

Query: 825  NETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEM 884
            N   +G D      V  KY   V++ +  L+ Y  ++ VE  AR  FLWK++   +KE +
Sbjct: 824  NPGLNGTD--RLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERV 881

Query: 885  EELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEA 944
             E++ +N  L+ N+LP+ VA HFL  ++R++ELY Q+ + + VMFAS+ NF++FY E   
Sbjct: 882  YEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESI 941

Query: 945  NNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGL----------NAST 994
            NN G+ECLR LNEII+DFD ++   +FR + KIKTIGSTYMAASG+          +++ 
Sbjct: 942  NNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNK 1001

Query: 995  YDQVGR---SHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQY 1051
             D+  R    H+  LAD+A+ + + + +IN  SFNNF ++IG+N G V+AGVIGARKP Y
Sbjct: 1002 EDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHY 1061

Query: 1052 DIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNG 1111
            DIWGNTVNV+SRM+STGV   IQV  +   +L   G++   RG + VKGKGE+ T+FL G
Sbjct: 1062 DIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKG 1121


>gi|50959205 adenylate cyclase 9 [Homo sapiens]
          Length = 1353

 Score =  216 bits (551), Expect = 7e-56
 Identities = 130/357 (36%), Positives = 201/357 (56%), Gaps = 36/357 (10%)

Query: 246 VYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQL-------NRGDAFLWKQLGANVLLFLC 298
           +++ YT++ + +  ++  G+  S L     +         + G   L  +L +  LL  C
Sbjct: 231 LFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGC 290

Query: 299 TNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEM---- 354
            + IG+     ++V  R  F +    I     L+ E   +ER++ SV+P+ +A ++    
Sbjct: 291 IHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQG 350

Query: 355 -------------------KEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQC 395
                              K+  + +K  + F    +Q+ + VSILFADI GFT +++  
Sbjct: 351 DEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANK 410

Query: 396 TAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMI 455
           +A  LV  LN+LF RFD+L  E  C +I  LGDCYYCV+G PE RADHA+CC+EMG+ MI
Sbjct: 411 SAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMI 470

Query: 456 EAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIH 515
           +AI    +     VNMRVG+H+G V CG+LG+R+++FDVWSNDV LAN ME  G AG++H
Sbjct: 471 KAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVH 530

Query: 516 ITRATLQYLNGDYEVEPGRGGER--NAYLKEQ--HIETFLILGASQKRKEEKAMLAK 568
           I+ AT +YL+  YE+E G+  ER   + + +Q   ++T+LI G  Q+ KE +   A+
Sbjct: 531 ISEATAKYLDDRYEMEDGKVIERLGQSVVADQLKGLKTYLISG--QRAKESRCSCAE 585



 Score =  197 bits (500), Expect = 6e-50
 Identities = 165/524 (31%), Positives = 254/524 (48%), Gaps = 60/524 (11%)

Query: 632  IDARSIDQLRKDH-----VRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFI 686
            +D    D L KD+     + +F L F  ++LE+ Y               +  F    F 
Sbjct: 729  VDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEE--VIKNSPVKTFASPTFS 786

Query: 687  QLL-IFPHSTLMLGIYASIFLLLLITVL-----ICAVYSCGSLFPKALQRLSRSIVRSRA 740
             LL +F  +T+ L +  + FL      +       AV+S   L    +  L+ SI     
Sbjct: 787  SLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLE--VLSLAVSIRMVFF 844

Query: 741  HSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLASSVFLHISS-----------IGKLAMI 789
                +     LL + +     + IG +L+SL A +V+ H++S            G  A+I
Sbjct: 845  LEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGSAALI 904

Query: 790  FVL---GLIYLVLLLLGPPATIFDNYDLLLGVHGLASSN----------ETFDGLDCPAA 836
             V+       L   +    AT+     LLL    L   +          + F     P  
Sbjct: 905  AVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCN 964

Query: 837  GRVALKYMTPV------ILLVFALALYLH---AQQVESTARLDFLWKLQATGEKEEMEEL 887
              V      P       ++LVF L L L     ++ E + RL +   ++A   + +++ +
Sbjct: 965  SSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSM 1024

Query: 888  QAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNE 947
            +     LL NI+P     + +A + +  + Y ++ +   V+FASI NFSEFY   E N E
Sbjct: 1025 RDQADWLLRNIIP-----YHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFY---EENYE 1076

Query: 948  G-VECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVG--RSHIT 1004
            G  EC R+LNE+I DFDE++S+  +  +EKIKTIG+TYMAASGLN +        + H+ 
Sbjct: 1077 GGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQ 1136

Query: 1005 ALADYAMRLMEQMKHINEHS-FNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSR 1063
             L ++A  +M  +   N +  + NF++++G N GP+ AGVIG  K  YDIWG+TVN++SR
Sbjct: 1137 ILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASR 1196

Query: 1064 MDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTY 1107
            MD+TGV  RIQV+ + Y+VL+  GY  + RG V VKGKG+M TY
Sbjct: 1197 MDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1240



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 103/508 (20%), Positives = 205/508 (40%), Gaps = 77/508 (15%)

Query: 652  FQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLIT 711
            F   +LE+    +  P+       AL    F C +  + F        ++    L++++ 
Sbjct: 95   FDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYF-------AVHMRSRLIVMVA 147

Query: 712  VLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFI------- 764
              +C +  C   F     +L         H     +   LLVF   +A  + +       
Sbjct: 148  PALCFLLVCVGFFLFTFTKLYAR------HYAWTSLALTLLVFALTLAAQFQVLTPVSGR 201

Query: 765  -GNMLLSLLASSVFLHISSIGKLAM-IFVLGLIYLVLLL-LGPPATIFDNYDLLLGVHGL 821
              +  L+  A      +S +G  +M I VL L+Y V+ L L     +   Y +L    G 
Sbjct: 202  GDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGY 261

Query: 822  ASSNETFDGLDCPAAGRVALKYMTPVIL--LVFALALYLHAQQVESTARLDFLWKLQATG 879
               +E       P AG +  + ++  +L   + A+ ++L     +  +R  FL   Q+  
Sbjct: 262  HFRDEAC--FPSPGAGALHWELLSRGLLHGCIHAIGVHLFVMS-QVRSRSTFLKVGQSIM 318

Query: 880  EKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDE----------------------- 916
              +++E  +A   R++H+++P+ +A   + +     E                       
Sbjct: 319  HGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKA 378

Query: 917  ------LYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEER 970
                     Q  E V+++FA I  F++    + AN      + LLN++   FD +  E +
Sbjct: 379  PIAFRPFKMQQIEEVSILFADIVGFTK----MSANKSAHALVGLLNDLFGRFDRLCEETK 434

Query: 971  FRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQM 1030
                EKI T+G  Y   +G      D     H     +  + +++ ++   +       M
Sbjct: 435  ---CEKISTLGDCYYCVAGCPEPRAD-----HAYCCIEMGLGMIKAIEQFCQEKKEMVNM 486

Query: 1031 KIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVT-------TDLYQVL 1083
            ++G++ G V+ G++G R+ ++D+W N VN+++ M+  GV  ++ ++        D Y++ 
Sbjct: 487  RVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEME 546

Query: 1084 AAKGYQLECRGVVKVKGKGEMTTYFLNG 1111
              K  +   + VV  + KG + TY ++G
Sbjct: 547  DGKVIERLGQSVVADQLKG-LKTYLISG 573



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 104/433 (24%), Positives = 174/433 (40%), Gaps = 80/433 (18%)

Query: 159  LVLLTAVLLAFHAAPARPQPAYVALLACAAALFV-GLMVVCNRHSFRQDSM--------W 209
            L L T   L + AA   P PA +A+ + A  L V  L V      F +D M        W
Sbjct: 799  LTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEW 858

Query: 210  VVSYVVLGILAAVQVG-GALAADPRSPS---AGLWCPVF---------FVYIAYTLLPIR 256
            +  ++    + A+ V   ALA      S     +  PVF           Y  +  L   
Sbjct: 859  IAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSW 918

Query: 257  MRAAVLSGLGLSTLHL----------ILAWQLNRGDAFLWKQLGAN-------------- 292
            MR+++ + +G   L L          +L   L+    F  ++   N              
Sbjct: 919  MRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLI 978

Query: 293  ----VLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLH---LQHENRQQERLLLSV 345
                VL+F    ++    +   EVS R  +    G ++A LH   +Q    Q + LL ++
Sbjct: 979  GQEVVLVFFLLLLLVWFLNREFEVSYRLHYH---GDVEADLHRTKIQSMRDQADWLLRNI 1035

Query: 346  LPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCT--AQELVMT 403
            +P HVA ++K             + Y + HD+  ++FA I  F+    +     +E    
Sbjct: 1036 IPYHVAEQLKVS-----------QTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRV 1084

Query: 404  LNELFARFDKLAAE---NHCLRIKILGDCYYCVSGLPEARA-------DHAHCCVEMGVD 453
            LNEL   FD+L ++   +   +IK +G  Y   SGL  A+A       +H     E   +
Sbjct: 1085 LNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKE 1144

Query: 454  MIEAIS-LVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAG 512
            M+  +      +   N  +RVG + G +  GV+G  K  +D+W + V +A+ M+  G   
Sbjct: 1145 MMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVEC 1204

Query: 513  RIHITRATLQYLN 525
            RI ++  + + L+
Sbjct: 1205 RIQVSEESYRVLS 1217


>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
            sapiens]
          Length = 1103

 Score =  119 bits (298), Expect = 2e-26
 Identities = 83/237 (35%), Positives = 127/237 (53%), Gaps = 25/237 (10%)

Query: 882  EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVE 941
            EE+E  +    RLL  +LP  VA           E + Q    V + F+ I  F+     
Sbjct: 840  EELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQ----VTLYFSDIVGFTT---- 891

Query: 942  LEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRS 1001
            + A +E +E + LLN++   FD II       + K++TIG  YM ASGL        G+ 
Sbjct: 892  ISAMSEPIEVVDLLNDLYTLFDAIIGSH---DVYKVETIGDAYMVASGLPQRN----GQR 944

Query: 1002 HITALADYAMRLME-----QMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGN 1056
            H   +A+ ++ ++      +M+H+ E      +++IGL+ GP VAGV+G   P+Y ++G+
Sbjct: 945  HAAEIANMSLDILSAVGTFRMRHMPEVPV---RIRIGLHSGPCVAGVVGLTMPRYCLFGD 1001

Query: 1057 TVNVSSRMDSTGVPDRIQVTTDLYQVLAA--KGYQLECRGVVKVKGKGEMTTYFLNG 1111
            TVN +SRM+STG+P RI V      +L A   GYQ+E RG  ++KGKG   T++L G
Sbjct: 1002 TVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVG 1058



 Score =  101 bits (251), Expect = 5e-21
 Identities = 67/225 (29%), Positives = 116/225 (51%), Gaps = 23/225 (10%)

Query: 331  LQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTS 390
            L+ E ++ +RLL  +LP  VA  +K     + E            + V++ F+DI GFT+
Sbjct: 842  LELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYF----------EQVTLYFSDIVGFTT 891

Query: 391  LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVE 449
            +++     E+V  LN+L+  FD +   +   +++ +GD Y   SGLP+     HA     
Sbjct: 892  ISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIAN 951

Query: 450  MGVDMIEAISL--VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEA 507
            M +D++ A+    +R +  V V +R+G+HSG    GV+GL   ++ ++ + V  A+ ME+
Sbjct: 952  MSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMES 1011

Query: 508  GGRAGRIHITRAT---LQYLNGDYEVE-------PGRGGERNAYL 542
             G   RIH+  +T   L+ L+  Y+VE        G+G E   +L
Sbjct: 1012 TGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWL 1056


>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
          Length = 1047

 Score =  119 bits (297), Expect = 2e-26
 Identities = 81/241 (33%), Positives = 128/241 (53%), Gaps = 24/241 (9%)

Query: 880  EKEEMEELQAYNRR------LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIA 933
            EK   E  QAY         LL+ ILP  VA       +R + +  ++ + V + F+ I 
Sbjct: 813  EKLVEERTQAYLEEKRKAEALLYQILPHSVAEQL----KRGETVQAEAFDSVTIYFSDIV 868

Query: 934  NFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNAS 993
             F+     L A +  ++ + LLN++   FD II       + K++TIG  YM  SGL   
Sbjct: 869  GFTA----LSAESTPMQVVTLLNDLYTCFDAIIDNF---DVYKVETIGDAYMVVSGLPGR 921

Query: 994  TYDQVGRSHITALADYAMRLMEQMK--HINEHSFNNFQMKIGLNMGPVVAGVIGARKPQY 1051
                 G+ H   +A  A+ L++ +    I     +  +++IG++ GPV AGV+G + P+Y
Sbjct: 922  N----GQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRY 977

Query: 1052 DIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG-YQLECRGVVKVKGKGEMTTYFLN 1110
             ++G+TVN +SRM+S G   +I V++     L   G +QLE RG V++KGKG+M TY+L 
Sbjct: 978  CLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLL 1037

Query: 1111 G 1111
            G
Sbjct: 1038 G 1038



 Score =  106 bits (264), Expect = 1e-22
 Identities = 70/237 (29%), Positives = 124/237 (52%), Gaps = 31/237 (13%)

Query: 319  QETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNV 378
            + T+ Y++       E R+ E LL  +LP  VA ++K     + E            D+V
Sbjct: 818  ERTQAYLE-------EKRKAEALLYQILPHSVAEQLKRGETVQAEAF----------DSV 860

Query: 379  SILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPE 438
            +I F+DI GFT+L+++ T  ++V  LN+L+  FD +       +++ +GD Y  VSGLP 
Sbjct: 861  TIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPG 920

Query: 439  ARAD-HAHCCVEMGVDMIEAIS--LVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVW 495
                 HA     M + +++A+S   +R      + +R+G+H+G V  GV+GL+  ++ ++
Sbjct: 921  RNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLF 980

Query: 496  SNDVTLANHMEAGGRAGRIHITRATLQYLN----------GDYEVEPGRGGERNAYL 542
             + V  A+ ME+ G+A +IH++  T   L+          GD E++ G+G  R  +L
Sbjct: 981  GDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMK-GKGKMRTYWL 1036


>gi|134152694 guanylate cyclase 2F [Homo sapiens]
          Length = 1108

 Score =  118 bits (296), Expect = 3e-26
 Identities = 79/237 (33%), Positives = 131/237 (55%), Gaps = 25/237 (10%)

Query: 882  EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVE 941
            EE+E  +    +LL  +LP  VA       ++   +  +  + V + F+ I  F+     
Sbjct: 844  EELEIEKQKTEKLLTQMLPPSVAESL----KKGCTVEPEGFDLVTLYFSDIVGFTT---- 895

Query: 942  LEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRS 1001
            + A +E +E + LLN++   FD II       + K++TIG  YM ASGL        G  
Sbjct: 896  ISAMSEPIEVVDLLNDLYTLFDAIIGSH---DVYKVETIGDAYMVASGLPKRN----GSR 948

Query: 1002 HITALADYAMRLME-----QMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGN 1056
            H   +A+ ++ ++      +M+H+ E      +++IGL+ GPVVAGV+G   P+Y ++G+
Sbjct: 949  HAAEIANMSLDILSSVGTFKMRHMPEVPV---RIRIGLHSGPVVAGVVGLTMPRYCLFGD 1005

Query: 1057 TVNVSSRMDSTGVPDRIQVTTDLYQVL--AAKGYQLECRGVVKVKGKGEMTTYFLNG 1111
            TVN +SRM+STG+P RI V+     +L   ++GY++E RG  ++KGKG   T++L G
Sbjct: 1006 TVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIG 1062



 Score =  107 bits (266), Expect = 8e-23
 Identities = 70/225 (31%), Positives = 119/225 (52%), Gaps = 23/225 (10%)

Query: 331  LQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTS 390
            L+ E ++ E+LL  +LP  VA  +K+    + E            D V++ F+DI GFT+
Sbjct: 846  LEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGF----------DLVTLYFSDIVGFTT 895

Query: 391  LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVE 449
            +++     E+V  LN+L+  FD +   +   +++ +GD Y   SGLP+     HA     
Sbjct: 896  ISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIAN 955

Query: 450  MGVDMIEAISL--VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEA 507
            M +D++ ++    +R +  V V +R+G+HSG V  GV+GL   ++ ++ + V  A+ ME+
Sbjct: 956  MSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMES 1015

Query: 508  GGRAGRIHITRAT---LQYLNGDYEVE-------PGRGGERNAYL 542
             G   RIH++ +T   LQ L+  YEVE        G+G E   +L
Sbjct: 1016 TGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWL 1060


>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
          Length = 1061

 Score =  117 bits (292), Expect = 8e-26
 Identities = 73/221 (33%), Positives = 124/221 (56%), Gaps = 18/221 (8%)

Query: 894  LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLR 953
            LL+ ILP  VA       +R + +  ++ + V + F+ I  F+     L A +  ++ + 
Sbjct: 848  LLYQILPHSVAEQL----KRGETVQAEAFDSVTIYFSDIVGFTA----LSAESTPMQVVT 899

Query: 954  LLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRL 1013
            LLN++   FD +I       + K++TIG  YM  SGL        GR H   +A  A+ L
Sbjct: 900  LLNDLYTCFDAVIDNF---DVYKVETIGDAYMVVSGLPVRN----GRLHACEVARMALAL 952

Query: 1014 MEQMK--HINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPD 1071
            ++ ++   I        +++IG++ GPV AGV+G + P+Y ++G+TVN +SRM+S G   
Sbjct: 953  LDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEAL 1012

Query: 1072 RIQVTTDLYQVLAA-KGYQLECRGVVKVKGKGEMTTYFLNG 1111
            +I ++++   VL    G++LE RG V++KGKG++ TY+L G
Sbjct: 1013 KIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLG 1053



 Score =  105 bits (263), Expect = 2e-22
 Identities = 73/238 (30%), Positives = 125/238 (52%), Gaps = 33/238 (13%)

Query: 319  QETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNV 378
            + T+ Y++       E R+ E LL  +LP  VA ++K     + E            D+V
Sbjct: 833  ERTQAYLE-------EKRKAEALLYQILPHSVAEQLKRGETVQAEAF----------DSV 875

Query: 379  SILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPE 438
            +I F+DI GFT+L+++ T  ++V  LN+L+  FD +       +++ +GD Y  VSGLP 
Sbjct: 876  TIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLP- 934

Query: 439  ARADHAHCC--VEMGVDMIEAIS--LVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDV 494
             R    H C    M + +++A+    +R      + +R+GIH+G V  GV+GL+  ++ +
Sbjct: 935  VRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCL 994

Query: 495  WSNDVTLANHMEAGGRAGRIHI---TRATLQ-------YLNGDYEVEPGRGGERNAYL 542
            + + V  A+ ME+ G A +IH+   T+A L+        L GD E++ G+G  R  +L
Sbjct: 995  FGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMK-GKGKVRTYWL 1051


>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
          Length = 732

 Score =  114 bits (286), Expect = 4e-25
 Identities = 64/194 (32%), Positives = 106/194 (54%), Gaps = 10/194 (5%)

Query: 331 LQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTS 390
           L+ E ++   LL S+ P  VA ++ +            ++  +K D+V++LF+DI GFT+
Sbjct: 483 LEEEKKKTVDLLYSIFPGDVAQQLWQG----------QQVQARKFDDVTMLFSDIVGFTA 532

Query: 391 LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM 450
           + +QCT  +++  LNEL+ RFD         +++ +GD Y   +GL      HA     M
Sbjct: 533 ICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALM 592

Query: 451 GVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGR 510
            + M+E    V    G  + MR+GIHSG V  GV+G+R  ++ ++ N+VTLA+  E+G  
Sbjct: 593 ALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSH 652

Query: 511 AGRIHITRATLQYL 524
             RI+++  T Q L
Sbjct: 653 PRRINVSPTTYQLL 666



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 62/212 (29%), Positives = 110/212 (51%), Gaps = 18/212 (8%)

Query: 874  KLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFAS 931
            KL+AT E+  + +EE +     LL++I P DVA        +  ++  +  + V ++F+ 
Sbjct: 471  KLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLW----QGQQVQARKFDDVTMLFSD 526

Query: 932  IANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLN 991
            I  F+    +       ++ + +LNE+   FD       F  + K++TIG  Y  A+GL+
Sbjct: 527  IVGFTAICAQCTP----MQVISMLNELYTRFDHQCG---FLDIYKVETIGDAYCVAAGLH 579

Query: 992  ASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQY 1051
              +       H   +A  A+++ME  + +        QM+IG++ G V+AGV+G R P+Y
Sbjct: 580  RKSL-----CHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRY 634

Query: 1052 DIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1083
             ++GN V ++S+ +S   P RI V+   YQ+L
Sbjct: 635  CLFGNNVTLASKFESGSHPRRINVSPTTYQLL 666


>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
           sapiens]
          Length = 455

 Score =  109 bits (272), Expect = 2e-23
 Identities = 62/199 (31%), Positives = 106/199 (53%), Gaps = 10/199 (5%)

Query: 326 QARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADI 385
           QA   L+ E ++   LL S+ P  VA ++ +             +  +K  NV++LF+DI
Sbjct: 203 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQG----------QVVQAKKFSNVTMLFSDI 252

Query: 386 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 445
            GFT++ SQC+  +++  LN L+ RFD+   E    +++ +GD Y    GL +    HA 
Sbjct: 253 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 312

Query: 446 CCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 505
               M + M+E    V    G  + MR+G+HSG V  GV+G++  ++ ++ N+VTLAN  
Sbjct: 313 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 372

Query: 506 EAGGRAGRIHITRATLQYL 524
           E+     +I+++  T + L
Sbjct: 373 ESCSVPRKINVSPTTYRLL 391



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 58/214 (27%), Positives = 107/214 (50%), Gaps = 18/214 (8%)

Query: 872  LWKLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 929
            L KL+AT E+  + +EE +     LL +I P +VA        +   +  +    V ++F
Sbjct: 194  LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 249

Query: 930  ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASG 989
            + I  F+    +       ++ + +LN +   FD+   E     + K++TIG  Y  A G
Sbjct: 250  SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 302

Query: 990  LNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKP 1049
            L+  +      +H   +A  A+++ME    +        +M+IGL+ G V AGV+G + P
Sbjct: 303  LHKES-----DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 357

Query: 1050 QYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1083
            +Y ++GN V ++++ +S  VP +I V+   Y++L
Sbjct: 358  RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 391


>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
           sapiens]
          Length = 690

 Score =  109 bits (272), Expect = 2e-23
 Identities = 62/199 (31%), Positives = 106/199 (53%), Gaps = 10/199 (5%)

Query: 326 QARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADI 385
           QA   L+ E ++   LL S+ P  VA ++ +             +  +K  NV++LF+DI
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQG----------QVVQAKKFSNVTMLFSDI 487

Query: 386 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 445
            GFT++ SQC+  +++  LN L+ RFD+   E    +++ +GD Y    GL +    HA 
Sbjct: 488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547

Query: 446 CCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 505
               M + M+E    V    G  + MR+G+HSG V  GV+G++  ++ ++ N+VTLAN  
Sbjct: 548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607

Query: 506 EAGGRAGRIHITRATLQYL 524
           E+     +I+++  T + L
Sbjct: 608 ESCSVPRKINVSPTTYRLL 626



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 58/214 (27%), Positives = 107/214 (50%), Gaps = 18/214 (8%)

Query: 872  LWKLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 929
            L KL+AT E+  + +EE +     LL +I P +VA        +   +  +    V ++F
Sbjct: 429  LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 484

Query: 930  ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASG 989
            + I  F+    +       ++ + +LN +   FD+   E     + K++TIG  Y  A G
Sbjct: 485  SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 537

Query: 990  LNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKP 1049
            L+  +      +H   +A  A+++ME    +        +M+IGL+ G V AGV+G + P
Sbjct: 538  LHKES-----DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592

Query: 1050 QYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1083
            +Y ++GN V ++++ +S  VP +I V+   Y++L
Sbjct: 593  RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626


>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
           sapiens]
          Length = 690

 Score =  109 bits (272), Expect = 2e-23
 Identities = 62/199 (31%), Positives = 106/199 (53%), Gaps = 10/199 (5%)

Query: 326 QARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADI 385
           QA   L+ E ++   LL S+ P  VA ++ +             +  +K  NV++LF+DI
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQG----------QVVQAKKFSNVTMLFSDI 487

Query: 386 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 445
            GFT++ SQC+  +++  LN L+ RFD+   E    +++ +GD Y    GL +    HA 
Sbjct: 488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547

Query: 446 CCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 505
               M + M+E    V    G  + MR+G+HSG V  GV+G++  ++ ++ N+VTLAN  
Sbjct: 548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607

Query: 506 EAGGRAGRIHITRATLQYL 524
           E+     +I+++  T + L
Sbjct: 608 ESCSVPRKINVSPTTYRLL 626



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 58/214 (27%), Positives = 107/214 (50%), Gaps = 18/214 (8%)

Query: 872  LWKLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 929
            L KL+AT E+  + +EE +     LL +I P +VA        +   +  +    V ++F
Sbjct: 429  LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 484

Query: 930  ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASG 989
            + I  F+    +       ++ + +LN +   FD+   E     + K++TIG  Y  A G
Sbjct: 485  SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 537

Query: 990  LNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKP 1049
            L+  +      +H   +A  A+++ME    +        +M+IGL+ G V AGV+G + P
Sbjct: 538  LHKES-----DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592

Query: 1050 QYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1083
            +Y ++GN V ++++ +S  VP +I V+   Y++L
Sbjct: 593  RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626


>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
           sapiens]
          Length = 690

 Score =  109 bits (272), Expect = 2e-23
 Identities = 62/199 (31%), Positives = 106/199 (53%), Gaps = 10/199 (5%)

Query: 326 QARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADI 385
           QA   L+ E ++   LL S+ P  VA ++ +             +  +K  NV++LF+DI
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQG----------QVVQAKKFSNVTMLFSDI 487

Query: 386 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 445
            GFT++ SQC+  +++  LN L+ RFD+   E    +++ +GD Y    GL +    HA 
Sbjct: 488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547

Query: 446 CCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 505
               M + M+E    V    G  + MR+G+HSG V  GV+G++  ++ ++ N+VTLAN  
Sbjct: 548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607

Query: 506 EAGGRAGRIHITRATLQYL 524
           E+     +I+++  T + L
Sbjct: 608 ESCSVPRKINVSPTTYRLL 626



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 58/214 (27%), Positives = 107/214 (50%), Gaps = 18/214 (8%)

Query: 872  LWKLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 929
            L KL+AT E+  + +EE +     LL +I P +VA        +   +  +    V ++F
Sbjct: 429  LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 484

Query: 930  ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASG 989
            + I  F+    +       ++ + +LN +   FD+   E     + K++TIG  Y  A G
Sbjct: 485  SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 537

Query: 990  LNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKP 1049
            L+  +      +H   +A  A+++ME    +        +M+IGL+ G V AGV+G + P
Sbjct: 538  LHKES-----DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592

Query: 1050 QYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1083
            +Y ++GN V ++++ +S  VP +I V+   Y++L
Sbjct: 593  RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626


>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
           sapiens]
          Length = 690

 Score =  109 bits (272), Expect = 2e-23
 Identities = 62/199 (31%), Positives = 106/199 (53%), Gaps = 10/199 (5%)

Query: 326 QARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADI 385
           QA   L+ E ++   LL S+ P  VA ++ +             +  +K  NV++LF+DI
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQG----------QVVQAKKFSNVTMLFSDI 487

Query: 386 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 445
            GFT++ SQC+  +++  LN L+ RFD+   E    +++ +GD Y    GL +    HA 
Sbjct: 488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547

Query: 446 CCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 505
               M + M+E    V    G  + MR+G+HSG V  GV+G++  ++ ++ N+VTLAN  
Sbjct: 548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607

Query: 506 EAGGRAGRIHITRATLQYL 524
           E+     +I+++  T + L
Sbjct: 608 ESCSVPRKINVSPTTYRLL 626



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 58/214 (27%), Positives = 107/214 (50%), Gaps = 18/214 (8%)

Query: 872  LWKLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 929
            L KL+AT E+  + +EE +     LL +I P +VA        +   +  +    V ++F
Sbjct: 429  LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 484

Query: 930  ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASG 989
            + I  F+    +       ++ + +LN +   FD+   E     + K++TIG  Y  A G
Sbjct: 485  SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 537

Query: 990  LNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKP 1049
            L+  +      +H   +A  A+++ME    +        +M+IGL+ G V AGV+G + P
Sbjct: 538  LHKES-----DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592

Query: 1050 QYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1083
            +Y ++GN V ++++ +S  VP +I V+   Y++L
Sbjct: 593  RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626


>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
           sapiens]
          Length = 624

 Score =  108 bits (269), Expect = 4e-23
 Identities = 61/195 (31%), Positives = 104/195 (53%), Gaps = 10/195 (5%)

Query: 326 QARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADI 385
           QA   L+ E ++   LL S+ P  VA ++ +             +  +K  NV++LF+DI
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQG----------QVVQAKKFSNVTMLFSDI 487

Query: 386 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 445
            GFT++ SQC+  +++  LN L+ RFD+   E    +++ +GD Y    GL +    HA 
Sbjct: 488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547

Query: 446 CCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 505
               M + M+E    V    G  + MR+G+HSG V  GV+G++  ++ ++ N+VTLAN  
Sbjct: 548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607

Query: 506 EAGGRAGRIHITRAT 520
           E+     +I+++  T
Sbjct: 608 ESCSVPRKINVSPTT 622



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 57/212 (26%), Positives = 105/212 (49%), Gaps = 18/212 (8%)

Query: 872  LWKLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 929
            L KL+AT E+  + +EE +     LL +I P +VA        +   +  +    V ++F
Sbjct: 429  LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 484

Query: 930  ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASG 989
            + I  F+    +       ++ + +LN +   FD+   E     + K++TIG  Y  A G
Sbjct: 485  SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 537

Query: 990  LNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKP 1049
            L+  +      +H   +A  A+++ME    +        +M+IGL+ G V AGV+G + P
Sbjct: 538  LHKES-----DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592

Query: 1050 QYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQ 1081
            +Y ++GN V ++++ +S  VP +I V+   Y+
Sbjct: 593  RYCLFGNNVTLANKFESCSVPRKINVSPTTYR 624


>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
          Length = 619

 Score =  105 bits (261), Expect = 3e-22
 Identities = 67/209 (32%), Positives = 109/209 (52%), Gaps = 18/209 (8%)

Query: 331 LQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTS 390
           L+ E ++ + LL SVLP  VA E++              +  +++DNV+ILF+ I GF +
Sbjct: 383 LEDEKKKTDTLLYSVLPPSVANELRHK----------RPVPAKRYDNVTILFSGIVGFNA 432

Query: 391 LASQCT----AQELVMTLNELFARFDKLAAENH---CLRIKILGDCYYCVSGLPEARADH 443
             S+      A ++V  LN+L+ RFD L          +++ +GD Y  VSGLPE    H
Sbjct: 433 FCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHH 492

Query: 444 AHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLAN 503
           A     + +DM+E    V +V G +V + +GIH+G V  GV+G R  ++ ++ N V L +
Sbjct: 493 ARSICHLALDMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTS 551

Query: 504 HMEAGGRAGRIHITRATLQYLNGDYEVEP 532
             E  G  G+I+++  T + L      +P
Sbjct: 552 RTETTGEKGKINVSEYTYRCLMSPENSDP 580



 Score =  100 bits (248), Expect = 1e-20
 Identities = 74/257 (28%), Positives = 129/257 (50%), Gaps = 19/257 (7%)

Query: 861  QQVESTARLDFLW-KLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYY 919
            ++ + T  L+ L  +LQ T     +E+ +     LL+++LP  VA       R    +  
Sbjct: 361  EEYKLTQELEILTDRLQLT--LRALEDEKKKTDTLLYSVLPPSVANEL----RHKRPVPA 414

Query: 920  QSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKT 979
            +  + V ++F+ I  F+ F  +  +    ++ + LLN++   FD +    +   + K++T
Sbjct: 415  KRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVET 474

Query: 980  IGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPV 1039
            +G  YM  SGL           H  ++   A+ +ME    +      + Q+ IG++ G V
Sbjct: 475  VGDKYMTVSGLPEPCIH-----HARSICHLALDMMEIAGQVQVDG-ESVQITIGIHTGEV 528

Query: 1040 VAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAA-----KGYQLECRG 1094
            V GVIG R P+Y ++GNTVN++SR ++TG   +I V+   Y+ L +       + LE RG
Sbjct: 529  VTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRG 588

Query: 1095 VVKVKGKGE-MTTYFLN 1110
             V +KGK E M  +FL+
Sbjct: 589  PVSMKGKKEPMQVWFLS 605


>gi|222080083 guanylate cyclase 2C [Homo sapiens]
          Length = 1073

 Score =  100 bits (249), Expect = 8e-21
 Identities = 72/223 (32%), Positives = 109/223 (48%), Gaps = 19/223 (8%)

Query: 893  RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL 952
            RL   +LP+ V      +     ELY    E V + F+ I  F+         +  +E +
Sbjct: 795  RLNFMLLPRLVVKSLKEKGFVEPELY----EEVTIYFSDIVGFTTIC----KYSTPMEVV 846

Query: 953  RLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMR 1012
             +LN+I   FD I+       + K++TIG  YM ASGL        G  H   +A  A+ 
Sbjct: 847  DMLNDIYKSFDHIVDHH---DVYKVETIGDAYMVASGLPKRN----GNRHAIDIAKMALE 899

Query: 1013 LMEQMKHINEHSFNNFQM--KIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVP 1070
            ++  M            +  +IG++ GP  AGV+G + P+Y ++G+TVN +SRM+STG+P
Sbjct: 900  ILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLP 959

Query: 1071 DRIQVTTDLYQVLAAKGYQL--ECRGVVKVKGKGEMTTYFLNG 1111
             RI V+     +L     Q   E RG   +KG+G  TTY+L G
Sbjct: 960  LRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTG 1002



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 75/293 (25%), Positives = 138/293 (47%), Gaps = 34/293 (11%)

Query: 334  ENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLAS 393
            E  + +RL   +LP+ V   +KE    + E           ++ V+I F+DI GFT++  
Sbjct: 789  ERDRADRLNFMLLPRLVVKSLKEKGFVEPE----------LYEEVTIYFSDIVGFTTICK 838

Query: 394  QCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVEMGV 452
              T  E+V  LN+++  FD +   +   +++ +GD Y   SGLP+   + HA    +M +
Sbjct: 839  YSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMAL 898

Query: 453  DMIEAISL--VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGR 510
            +++  +    +  + G+ + +R+G+HSG    GV+G++  ++ ++ + V  A+ ME+ G 
Sbjct: 899  EILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGL 958

Query: 511  AGRIHITRATLQYLNGD-----YEVE-----PGRGGERNAYLKEQHIETF------LILG 554
              RIH++ +T+  L        YEV       GRG E   +L     + F       +  
Sbjct: 959  PLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVEN 1018

Query: 555  ASQKRKEEKAMLA-KLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDD 606
              + + E   M+A  LQ+ +A  +    PR    R  S  K +  + Q+   D
Sbjct: 1019 QQRLQAEFSDMIANSLQKRQAAGIRSQKPR----RVASYKKGTLEYLQLNTTD 1067


>gi|225579067 solute carrier family 12, member 4 isoform e [Homo
           sapiens]
          Length = 1054

 Score = 37.4 bits (85), Expect = 0.080
 Identities = 58/248 (23%), Positives = 101/248 (40%), Gaps = 37/248 (14%)

Query: 603 GIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYS 662
           GID   ++    ++ L+   +V   L + +   ++ Q  K+H         R    +  S
Sbjct: 27  GIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPS 86

Query: 663 RKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGS 722
             +    G Y+ C   +F  I F++L      T M+G  A +   LLI ++ C    C +
Sbjct: 87  --MGTLMGVYLPCLQNIFGVILFLRL------TWMVGT-AGVLQALLIVLICC----CCT 133

Query: 723 LFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLASSVFLHISS 782
           L    L  +S S + +     A G + ++    S      F G + L     + F     
Sbjct: 134 L----LTAISMSAIATNGVVPAGGSYFMI----SRSLGPEFGGAVGLCFYLGTTFA---- 181

Query: 783 IGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALK 842
               A +++LG I ++L  + PPA IF       G H   +SN T + +     G + L 
Sbjct: 182 ----AAMYILGAIEILLTYIAPPAAIF----YPSGAHD--TSNATLNNM--RVYGTIFLT 229

Query: 843 YMTPVILL 850
           +MT V+ +
Sbjct: 230 FMTLVVFV 237


>gi|225579065 solute carrier family 12, member 4 isoform d [Homo
           sapiens]
          Length = 1079

 Score = 37.4 bits (85), Expect = 0.080
 Identities = 58/248 (23%), Positives = 101/248 (40%), Gaps = 37/248 (14%)

Query: 603 GIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYS 662
           GID   ++    ++ L+   +V   L + +   ++ Q  K+H         R    +  S
Sbjct: 52  GIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPS 111

Query: 663 RKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGS 722
             +    G Y+ C   +F  I F++L      T M+G  A +   LLI ++ C    C +
Sbjct: 112 --MGTLMGVYLPCLQNIFGVILFLRL------TWMVGT-AGVLQALLIVLICC----CCT 158

Query: 723 LFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLASSVFLHISS 782
           L    L  +S S + +     A G + ++    S      F G + L     + F     
Sbjct: 159 L----LTAISMSAIATNGVVPAGGSYFMI----SRSLGPEFGGAVGLCFYLGTTFA---- 206

Query: 783 IGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALK 842
               A +++LG I ++L  + PPA IF       G H   +SN T + +     G + L 
Sbjct: 207 ----AAMYILGAIEILLTYIAPPAAIF----YPSGAHD--TSNATLNNM--RVYGTIFLT 254

Query: 843 YMTPVILL 850
           +MT V+ +
Sbjct: 255 FMTLVVFV 262


>gi|225579061 solute carrier family 12, member 4 isoform b [Homo
           sapiens]
          Length = 1079

 Score = 37.4 bits (85), Expect = 0.080
 Identities = 58/248 (23%), Positives = 101/248 (40%), Gaps = 37/248 (14%)

Query: 603 GIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYS 662
           GID   ++    ++ L+   +V   L + +   ++ Q  K+H         R    +  S
Sbjct: 58  GIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPS 117

Query: 663 RKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGS 722
             +    G Y+ C   +F  I F++L      T M+G  A +   LLI ++ C    C +
Sbjct: 118 --MGTLMGVYLPCLQNIFGVILFLRL------TWMVGT-AGVLQALLIVLICC----CCT 164

Query: 723 LFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLASSVFLHISS 782
           L    L  +S S + +     A G + ++    S      F G + L     + F     
Sbjct: 165 L----LTAISMSAIATNGVVPAGGSYFMI----SRSLGPEFGGAVGLCFYLGTTFA---- 212

Query: 783 IGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALK 842
               A +++LG I ++L  + PPA IF       G H   +SN T + +     G + L 
Sbjct: 213 ----AAMYILGAIEILLTYIAPPAAIF----YPSGAHD--TSNATLNNM--RVYGTIFLT 260

Query: 843 YMTPVILL 850
           +MT V+ +
Sbjct: 261 FMTLVVFV 268


>gi|4827006 solute carrier family 12, member 4 isoform a [Homo
           sapiens]
          Length = 1085

 Score = 37.4 bits (85), Expect = 0.080
 Identities = 58/248 (23%), Positives = 101/248 (40%), Gaps = 37/248 (14%)

Query: 603 GIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYS 662
           GID   ++    ++ L+   +V   L + +   ++ Q  K+H         R    +  S
Sbjct: 58  GIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPS 117

Query: 663 RKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGS 722
             +    G Y+ C   +F  I F++L      T M+G  A +   LLI ++ C    C +
Sbjct: 118 --MGTLMGVYLPCLQNIFGVILFLRL------TWMVGT-AGVLQALLIVLICC----CCT 164

Query: 723 LFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLASSVFLHISS 782
           L    L  +S S + +     A G + ++    S      F G + L     + F     
Sbjct: 165 L----LTAISMSAIATNGVVPAGGSYFMI----SRSLGPEFGGAVGLCFYLGTTFA---- 212

Query: 783 IGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALK 842
               A +++LG I ++L  + PPA IF       G H   +SN T + +     G + L 
Sbjct: 213 ----AAMYILGAIEILLTYIAPPAAIF----YPSGAHD--TSNATLNNM--RVYGTIFLT 260

Query: 843 YMTPVILL 850
           +MT V+ +
Sbjct: 261 FMTLVVFV 268


>gi|225579063 solute carrier family 12, member 4 isoform c [Homo
           sapiens]
          Length = 1087

 Score = 35.8 bits (81), Expect = 0.23
 Identities = 47/181 (25%), Positives = 77/181 (42%), Gaps = 35/181 (19%)

Query: 670 GAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQ 729
           G Y+ C   +F  I F++L      T M+G  A +   LLI ++ C    C +L    L 
Sbjct: 125 GVYLPCLQNIFGVILFLRL------TWMVGT-AGVLQALLIVLICC----CCTL----LT 169

Query: 730 RLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLASSVFLHISSIGKLAMI 789
            +S S + +     A G + ++    S      F G + L     + F         A +
Sbjct: 170 AISMSAIATNGVVPAGGSYFMI----SRSLGPEFGGAVGLCFYLGTTFA--------AAM 217

Query: 790 FVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVIL 849
           ++LG I ++L  + PPA IF       G H   +SN T + +     G + L +MT V+ 
Sbjct: 218 YILGAIEILLTYIAPPAAIF----YPSGAHD--TSNATLNNM--RVYGTIFLTFMTLVVF 269

Query: 850 L 850
           +
Sbjct: 270 V 270


>gi|239754370 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 435

 Score = 35.0 bits (79), Expect = 0.40
 Identities = 29/101 (28%), Positives = 41/101 (40%), Gaps = 14/101 (13%)

Query: 25  QKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAFIR--------RGGP 76
           ++R  R G +AGG      +   R   P S  PA    CP   D+F R        +  P
Sbjct: 63  KRRRERAGRKAGGDFRDLSLPLARSLPPESRRPARRANCP---DSFRRVLVNHLAQKRSP 119

Query: 77  GKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRS 117
              +    +AV L   + EV T +GG A   PD    + R+
Sbjct: 120 TPAR---YKAVRLAEREREVRTPSGGAAPCVPDEPAPAART 157


>gi|239748924 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 435

 Score = 35.0 bits (79), Expect = 0.40
 Identities = 29/101 (28%), Positives = 41/101 (40%), Gaps = 14/101 (13%)

Query: 25  QKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAFIR--------RGGP 76
           ++R  R G +AGG      +   R   P S  PA    CP   D+F R        +  P
Sbjct: 63  KRRRERAGRKAGGDFRDLSLPLARSLPPESRRPARRANCP---DSFRRVLVNHLAQKRSP 119

Query: 77  GKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRS 117
              +    +AV L   + EV T +GG A   PD    + R+
Sbjct: 120 TPAR---YKAVRLAEREREVRTPSGGAAPCVPDEPAPAART 157


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.138    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,255,413
Number of Sequences: 37866
Number of extensions: 1792961
Number of successful extensions: 7942
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 28
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 7734
Number of HSP's gapped (non-prelim): 112
length of query: 1115
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1002
effective length of database: 13,968,660
effective search space: 13996597320
effective search space used: 13996597320
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.