Search of human proteins with 93277076

Search of human proteins with 93277076

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|93277076 CDK5 regulatory subunit associated protein 1-like 1
[Homo sapiens]
         (579 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|93277076 CDK5 regulatory subunit associated protein 1-like 1 ...  1172   0.0  
gi|28872782 CDK5 regulatory subunit associated protein 1 isoform...   130   3e-30
gi|28872784 CDK5 regulatory subunit associated protein 1 isoform...   121   2e-27
gi|156616308 SET and MYND domain containing 4 [Homo sapiens]           31   2.7  
gi|24307911 acid sphingomyelinase-like phosphodiesterase 3A [Hom...    31   3.6  
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H...    30   7.9  
gi|23943912 phosphoinositide-3-kinase, regulatory subunit 4 [Hom...    30   7.9  
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]             30   7.9  

>gi|93277076 CDK5 regulatory subunit associated protein 1-like 1
           [Homo sapiens]
          Length = 579

 Score = 1172 bits (3033), Expect = 0.0
 Identities = 579/579 (100%), Positives = 579/579 (100%)

Query: 1   MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTI 60
           MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTI
Sbjct: 1   MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTI 60

Query: 61  PGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFR 120
           PGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFR
Sbjct: 61  PGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFR 120

Query: 121 NSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG 180
           NSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
Sbjct: 121 NSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG 180

Query: 181 QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVD 240
           QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVD
Sbjct: 181 QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVD 240

Query: 241 RAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILE 300
           RAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILE
Sbjct: 241 RAKQSFQEGVCEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILE 300

Query: 301 HLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT 360
           HLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
Sbjct: 301 HLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT 360

Query: 361 DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDL 420
           DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDL
Sbjct: 361 DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDL 420

Query: 421 SRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIY 480
           SRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIY
Sbjct: 421 SRVFHSYSPYDHKIGERQQVLVTEESFDSKFYVAHNQFYEQVLVPKNPAFMGKMVEVDIY 480

Query: 481 ESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSHTSAASQCDS 540
           ESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSHTSAASQCDS
Sbjct: 481 ESGKHFMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSHTSAASQCDS 540

Query: 541 ASSRMVLPMPRLHQDCALRMSVGLALLGLLFAFFVKVYN 579
           ASSRMVLPMPRLHQDCALRMSVGLALLGLLFAFFVKVYN
Sbjct: 541 ASSRMVLPMPRLHQDCALRMSVGLALLGLLFAFFVKVYN 579


>gi|28872782 CDK5 regulatory subunit associated protein 1 isoform a
           [Homo sapiens]
          Length = 587

 Score =  130 bits (327), Expect = 3e-30
 Identities = 116/480 (24%), Positives = 223/480 (46%), Gaps = 71/480 (14%)

Query: 14  EDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPP---SDSTIPGIQKIWIRT 70
           +D  S+  + P  +HF++    P+      +K   E E+ PP    D  +   +K+++ T
Sbjct: 53  KDFSSRLAAGPTFQHFLKSASAPQ------EKLSSEVEDPPPYLMMDELLGRQRKVYLET 106

Query: 71  WGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAED------HFRNSIK 124
           +GC  N +D E     L   GY  T N  +AD+ LL +C+++  AE       H   ++K
Sbjct: 107 YGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKALK 166

Query: 125 KAQEENK---KIVLAGCVPQAQPRQDYLKGLSIIGV-------QQIDRVVEVVEETIKGH 174
             +  ++   +I + GC+ + + +++ L    ++ +       + + R++ V E   +  
Sbjct: 167 TRRPRSRVPLRIGILGCMAE-RLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAA 225

Query: 175 SVRLLGQKKDNGRRLGGARLDLPKIRKNPLIE--IISINTGCLNACTYCKTKHARGNLAS 232
           +V L          L     D+  ++ +       +SI  GC N C+YC     RG   S
Sbjct: 226 NVLL---------SLDETYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERS 276

Query: 233 YPIDELVDRAKQSFQEGVCEIWLTSEDTGAY----------------GRDIGTNLPT--- 273
            PI  +++  K+  ++G+ E+ L  ++  ++                 R   TN  T   
Sbjct: 277 RPIASILEEVKKLSEQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNLSRGFTTNYKTKQG 336

Query: 274 ------LLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNH-PRVYAFLHIPVQSAS 326
                 LL ++  V PE   +R+  T+P +  +  +E+ ++++    +   +H+P QS S
Sbjct: 337 GLRFAHLLDQVSRVDPE---MRIRFTSP-HPKDFPDEVLQLIHERDNICKQIHLPAQSGS 392

Query: 327 DSVLMEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKF 386
             VL  M+R Y    +  +V  ++E +PG+++++D I GF GET++D  +TV L+ E ++
Sbjct: 393 SRVLEAMRRGYSREAYVELVHHIRESIPGVSLSSDFIAGFCGETEEDHVQTVSLLREVQY 452

Query: 387 PSLFINQFYPRPGTPA--AKMEQVPAQVKKQRTKDLSRVFHSYSPYDHK--IGERQQVLV 442
              F+  +  R  T A     + VP +VK +R ++L  +F   +   ++  +G  Q VLV
Sbjct: 453 NMGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELITIFREEATKANQTSVGCTQLVLV 512


>gi|28872784 CDK5 regulatory subunit associated protein 1 isoform b
           [Homo sapiens]
          Length = 497

 Score =  121 bits (304), Expect = 2e-27
 Identities = 104/427 (24%), Positives = 201/427 (47%), Gaps = 62/427 (14%)

Query: 64  QKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAED------ 117
           +K+++ T+GC  N +D E     L   GY  T N  +AD+ LL +C+++  AE       
Sbjct: 10  RKVYLETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRL 69

Query: 118 HFRNSIKKAQEENK---KIVLAGCVPQAQPRQDYLKGLSIIGV-------QQIDRVVEVV 167
           H   ++K  +  ++   +I + GC+ + + +++ L    ++ +       + + R++ V 
Sbjct: 70  HQLKALKTRRPRSRVPLRIGILGCMAE-RLKEEILNREKMVDILAGPDAYRDLPRLLAVA 128

Query: 168 EETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIE--IISINTGCLNACTYCKTKH 225
           E   +  +V L          L     D+  ++ +       +SI  GC N C+YC    
Sbjct: 129 ESGQQAANVLL---------SLDETYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPF 179

Query: 226 ARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAY----------------GRDIGT 269
            RG   S PI  +++  K+  ++G+ E+ L  ++  ++                 R   T
Sbjct: 180 TRGRERSRPIASILEEVKKLSEQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNLSRGFTT 239

Query: 270 NLPT---------LLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNH-PRVYAFLH 319
           N  T         LL ++  V PE   +R+  T+P +  +  +E+ ++++    +   +H
Sbjct: 240 NYKTKQGGLRFAHLLDQVSRVDPE---MRIRFTSP-HPKDFPDEVLQLIHERDNICKQIH 295

Query: 320 IPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVK 379
           +P QS S  VL  M+R Y    +  +V  ++E +PG+++++D I GF GET++D  +TV 
Sbjct: 296 LPAQSGSSRVLEAMRRGYSREAYVELVHHIRESIPGVSLSSDFIAGFCGETEEDHVQTVS 355

Query: 380 LVEEYKFPSLFINQFYPRPGTPA--AKMEQVPAQVKKQRTKDLSRVFHSYSPYDHK--IG 435
           L+ E ++   F+  +  R  T A     + VP +VK +R ++L  +F   +   ++  +G
Sbjct: 356 LLREVQYNMGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELITIFREEATKANQTSVG 415

Query: 436 ERQQVLV 442
             Q VLV
Sbjct: 416 CTQLVLV 422


>gi|156616308 SET and MYND domain containing 4 [Homo sapiens]
          Length = 804

 Score = 31.2 bits (69), Expect = 2.7
 Identities = 21/87 (24%), Positives = 35/87 (40%), Gaps = 2/87 (2%)

Query: 386 FPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKIG--ERQQVLVT 443
           FP + +      P T  + +  V      QR +    + H Y P+  ++G  ERQQ L +
Sbjct: 532 FPVISLLNHSCSPNTSVSFISTVATIRASQRIRKGQEILHCYGPHKSRMGVAERQQKLRS 591

Query: 444 EESFDSKFYVAHNQFYEQVLVPKNPAF 470
           +  FD        + +     P+  AF
Sbjct: 592 QYFFDCACPACQTEAHRMAAGPRWEAF 618


>gi|24307911 acid sphingomyelinase-like phosphodiesterase 3A [Homo
           sapiens]
          Length = 453

 Score = 30.8 bits (68), Expect = 3.6
 Identities = 56/253 (22%), Positives = 100/253 (39%), Gaps = 36/253 (14%)

Query: 196 LPKIRKNPLIEIISINTGCLNAC-TYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIW 254
           +P++  + +I +I+  T  + +     +   A GN   +P D+L     + +   V  +W
Sbjct: 117 VPELSTDTVINVITNMTTTIQSLFPNLQVFPALGNHDYWPQDQLPVVTSKVYN-AVANLW 175

Query: 255 L---------TSEDTGAYGRDIGTNLPTLLWKLVEVIPEGA-MLRLGMTNPPYILEHLEE 304
                     T    G Y + + TN    +  L   +  G  ++ L  T+P    E LE 
Sbjct: 176 KPWLDEEAISTLRKGGFYSQKVTTNPNLRIISLNTNLYYGPNIMTLNKTDPANQFEWLES 235

Query: 305 MAKIL--NHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIATDI 362
                  N  +VY   H+PV     S  +   REY     ++++D  ++        +D+
Sbjct: 236 TLNNSQQNKEKVYIIAHVPVGYLPSSQNITAMREYY---NEKLIDIFQK-------YSDV 285

Query: 363 ICG-FPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLS 421
           I G F G T +D    +   +     SLF+          A  +  V + ++KQ      
Sbjct: 286 IAGQFYGHTHRDSIMVLSDKKGSPVNSLFV----------APAVTPVKSVLEKQTNNPGI 335

Query: 422 RVFHSYSPYDHKI 434
           R+F  Y P D+K+
Sbjct: 336 RLF-QYDPRDYKL 347


>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
            sapiens]
          Length = 1512

 Score = 29.6 bits (65), Expect = 7.9
 Identities = 17/63 (26%), Positives = 29/63 (46%), Gaps = 1/63 (1%)

Query: 486  FMKGQPVSDAKVYTPSISKPLAKGEVSGLTKDFRNGLGNQLSSGSHTSAASQCDSASSRM 545
            F + +P+  + ++ P  S+P   G  S      +N +   L+S S    +  C S SS  
Sbjct: 1046 FTQSRPLPSSNIHRPKPSRP-TPGNTSKQGDPSKNSMTLDLNSSSKCDDSFGCSSNSSNA 1104

Query: 546  VLP 548
            V+P
Sbjct: 1105 VIP 1107


>gi|23943912 phosphoinositide-3-kinase, regulatory subunit 4 [Homo
           sapiens]
          Length = 1358

 Score = 29.6 bits (65), Expect = 7.9
 Identities = 20/70 (28%), Positives = 34/70 (48%), Gaps = 6/70 (8%)

Query: 163 VVEVVEETIKGHSVRLLGQKKDNGRRLGG-ARLDLPKI-----RKNPLIEIISINTGCLN 216
           + +  +ET      R+L  +KD G  +      DLP+      ++N L+ ++S+ T CL 
Sbjct: 328 MAQFAKETFLSADERILVIRKDLGNIIHNLCGHDLPEKAEGEPKENGLVILVSVITSCLQ 387

Query: 217 ACTYCKTKHA 226
              YC +K A
Sbjct: 388 TLKYCDSKLA 397


>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
          Length = 871

 Score = 29.6 bits (65), Expect = 7.9
 Identities = 16/49 (32%), Positives = 28/49 (57%), Gaps = 6/49 (12%)

Query: 345 VVDFLKEKVPGITIATDIICGFPGETD------QDFQETVKLVEEYKFP 387
           VV  L++K  GI+    +I  FPG+ D      +D +E +K++ ++ FP
Sbjct: 438 VVVSLQKKPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFP 486


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,572,095
Number of Sequences: 37866
Number of extensions: 1025838
Number of successful extensions: 2506
Number of sequences better than 10.0: 8
Number of HSP's better than 10.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 2497
Number of HSP's gapped (non-prelim): 10
length of query: 579
length of database: 18,247,518
effective HSP length: 108
effective length of query: 471
effective length of database: 14,157,990
effective search space: 6668413290
effective search space used: 6668413290
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.