Search of human proteins with 88196794

Search of human proteins with 88196794

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|88196794 kelch-like 35 [Homo sapiens]
         (363 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|88196794 kelch-like 35 [Homo sapiens]                              750   0.0  
gi|40018614 DRE1 protein [Homo sapiens]                               384   e-107
gi|109150407 kelch-like 6 [Homo sapiens]                              295   3e-80
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]     199   3e-51
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai...   199   3e-51
gi|55925608 kelch-like 21 [Homo sapiens]                              179   5e-45
gi|40807500 kelch-like 20 [Homo sapiens]                              154   2e-37
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]                     153   2e-37
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]                     153   2e-37
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]                     153   2e-37
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]            148   7e-36
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]            148   7e-36
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]            148   7e-36
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]               145   6e-35
gi|128485503 kelch-like 30 [Homo sapiens]                             142   4e-34
gi|38194229 kelch-like 17 [Homo sapiens]                              142   6e-34
gi|166235129 kelch-like 3 [Homo sapiens]                              141   1e-33
gi|11056006 kelch-like 12 [Homo sapiens]                              137   1e-32
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo...   136   3e-32
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]                     135   7e-32
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]                     135   7e-32
gi|14780904 kelch-like 1 protein [Homo sapiens]                       134   1e-31
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]              134   1e-31
gi|148664209 kelch-like 10 [Homo sapiens]                             126   3e-29
gi|55925604 kelch-like 18 [Homo sapiens]                              124   1e-28
gi|194097389 kelch-like 38 [Homo sapiens]                             124   2e-28
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]        122   7e-28
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]        122   7e-28
gi|40255071 kelch-like 23 [Homo sapiens]                              121   9e-28
gi|8922854 kelch-like 26 [Homo sapiens]                               117   2e-26

>gi|88196794 kelch-like 35 [Homo sapiens]
          Length = 363

 Score =  750 bits (1936), Expect = 0.0
 Identities = 363/363 (100%), Positives = 363/363 (100%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI
Sbjct: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60

Query: 61  LGREAGALRTRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTR 120
           LGREAGALRTRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTR
Sbjct: 61  LGREAGALRTRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTR 120

Query: 121 SEFAACALRNDVYVSGGHINSHDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVG 180
           SEFAACALRNDVYVSGGHINSHDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVG
Sbjct: 121 SEFAACALRNDVYVSGGHINSHDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVG 180

Query: 181 GFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVNTDKVQ 240
           GFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVNTDKVQ
Sbjct: 181 GFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVNTDKVQ 240

Query: 241 CFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGLMSKIFTYDPGTDVWGEAAVLPSP 300
           CFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGLMSKIFTYDPGTDVWGEAAVLPSP
Sbjct: 241 CFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGLMSKIFTYDPGTDVWGEAAVLPSP 300

Query: 301 VESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQPSLQRCTSSHGCVTIIQS 360
           VESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQPSLQRCTSSHGCVTIIQS
Sbjct: 301 VESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQPSLQRCTSSHGCVTIIQS 360

Query: 361 LGR 363
           LGR
Sbjct: 361 LGR 363


>gi|40018614 DRE1 protein [Homo sapiens]
          Length = 600

 Score =  384 bits (987), Expect = e-107
 Identities = 189/357 (52%), Positives = 240/357 (67%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           MRWV      RR  L  LL HVRLPLL P YF++ VE D+L+Q   EC  LL EAR   I
Sbjct: 234 MRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHI 293

Query: 61  LGREAGALRTRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTR 120
           LG E  + RTRPRR    +EVIVV+GGC+R G   LP+ + Y P +  W  L  LP +T+
Sbjct: 294 LGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTK 353

Query: 121 SEFAACALRNDVYVSGGHINSHDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVG 180
           SE+A CALRND+ VSGG INS DVW+++S L+ WI+VASL+KGRWRHKMAV+ G+++ VG
Sbjct: 354 SEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVG 413

Query: 181 GFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVNTDKVQ 240
           G+DG  RL SVE YD FSN W   APL EAVSS AV SC GKLFVIGG       +DKVQ
Sbjct: 414 GYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQ 473

Query: 241 CFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGLMSKIFTYDPGTDVWGEAAVLPSP 300
            +DP+ + W LR+  P ++RC+ AVSL + IYV GGL   I+ YDP  D W       S 
Sbjct: 474 SYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSR 533

Query: 301 VESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQPSLQRCTSSHGCVTI 357
            E+CG++VC+GK++ILGGR + GE+TD +  +DP++  +    ++ R  S HGCVTI
Sbjct: 534 QENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTI 590


>gi|109150407 kelch-like 6 [Homo sapiens]
          Length = 621

 Score =  295 bits (756), Expect = 3e-80
 Identities = 156/368 (42%), Positives = 216/368 (58%), Gaps = 8/368 (2%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           M WVRH    R   L  +LE+VRLPLL P YF+E VEAD L++ C E  PLL EAR   +
Sbjct: 240 MSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHL 299

Query: 61  LGREAGALRTRPRRFMDLAEVIVVIGGC--DRKGLLKLPFADAYHPESQRWTPLPSLPGY 118
            G E  + RT+PR     +EV ++IGGC  D + + ++   D           LP     
Sbjct: 300 SGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHE 359

Query: 119 TRSE------FAACALRNDVYVSGGHINSHDVWMFSSHLHTWIKVASLHKGRWRHKMAVV 172
             SE      FA   L+N+VY+SGG    HDVW ++S ++ WI++  L+ GRWRHKM V+
Sbjct: 360 LESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVL 419

Query: 173 QGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQG 232
            G+++ +GGFDGL+R+++VE YDPF N W+ AAPL   VSS A  S   KL+VIGG   G
Sbjct: 420 GGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNG 479

Query: 233 GVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGLMSKIFTYDPGTDVWG 292
            + TDK QC+DP  ++WSL++  P   +C+ AVS  D IYV+GG M  ++ Y P  D W 
Sbjct: 480 KLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLEDSWC 539

Query: 293 EAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQPSLQRCTSSH 352
               L     SCG+  C+ +++I GGRD++ E    V  +DP + ++  +  L R  S H
Sbjct: 540 LVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHH 599

Query: 353 GCVTIIQS 360
           G VTI +S
Sbjct: 600 GSVTIRKS 607


>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
          Length = 875

 Score =  199 bits (506), Expect = 3e-51
 Identities = 116/367 (31%), Positives = 185/367 (50%), Gaps = 10/367 (2%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           ++W++ D   R      LL  VRLP + P+Y L  V+ +EL+++   CR L+ EA+   +
Sbjct: 502 IKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHM 561

Query: 61  LG---REAGALRTRPRRFMDLAEVIVVIGGCDRKGLLK--LPFADAYHPESQRWTPLPSL 115
           L    +E    RTRPR    +AEVIV++GG    G+ +  L     ++P++ +W PL SL
Sbjct: 562 LPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASL 621

Query: 116 PGYTRSEFAACALRNDVYVSGGH---INSHDVWMFSSHLHTWIKVASLHKGRWRHKMAVV 172
           P Y R  F+  +  +++Y+SGG    +   DVW + S L  W  V+ +   R RH   V 
Sbjct: 622 PFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVY 681

Query: 173 QGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQG 232
            G+++ +GG      +  VERYD  +N W A APLP+AV SAA   C GK++V GG  + 
Sbjct: 682 DGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEA 741

Query: 233 GVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGLMSKIFT-YDPGTDVW 291
           G     +Q + P+ + WS         +   AV+L   ++++GG  ++  T YDP     
Sbjct: 742 GRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYARATTIYDPEKGNI 801

Query: 292 GEAAVLPSPVESCGVTVCDGKVHILGG-RDDRGESTDKVFTFDPSSGQVEVQPSLQRCTS 350
                +    + C   V DGK++  GG     G +   +  ++P++    + P +     
Sbjct: 802 KAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHMPCPVF 861

Query: 351 SHGCVTI 357
            HGCV I
Sbjct: 862 RHGCVVI 868


>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
           containing 9 [Homo sapiens]
          Length = 875

 Score =  199 bits (506), Expect = 3e-51
 Identities = 116/367 (31%), Positives = 185/367 (50%), Gaps = 10/367 (2%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           ++W++ D   R      LL  VRLP + P+Y L  V+ +EL+++   CR L+ EA+   +
Sbjct: 502 IKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHM 561

Query: 61  LG---REAGALRTRPRRFMDLAEVIVVIGGCDRKGLLK--LPFADAYHPESQRWTPLPSL 115
           L    +E    RTRPR    +AEVIV++GG    G+ +  L     ++P++ +W PL SL
Sbjct: 562 LPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASL 621

Query: 116 PGYTRSEFAACALRNDVYVSGGH---INSHDVWMFSSHLHTWIKVASLHKGRWRHKMAVV 172
           P Y R  F+  +  +++Y+SGG    +   DVW + S L  W  V+ +   R RH   V 
Sbjct: 622 PFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVY 681

Query: 173 QGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQG 232
            G+++ +GG      +  VERYD  +N W A APLP+AV SAA   C GK++V GG  + 
Sbjct: 682 DGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEA 741

Query: 233 GVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGLMSKIFT-YDPGTDVW 291
           G     +Q + P+ + WS         +   AV+L   ++++GG  ++  T YDP     
Sbjct: 742 GRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYARATTIYDPEKGNI 801

Query: 292 GEAAVLPSPVESCGVTVCDGKVHILGG-RDDRGESTDKVFTFDPSSGQVEVQPSLQRCTS 350
                +    + C   V DGK++  GG     G +   +  ++P++    + P +     
Sbjct: 802 KAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHMPCPVF 861

Query: 351 SHGCVTI 357
            HGCV I
Sbjct: 862 RHGCVVI 868


>gi|55925608 kelch-like 21 [Homo sapiens]
          Length = 597

 Score =  179 bits (453), Expect = 5e-45
 Identities = 117/371 (31%), Positives = 181/371 (48%), Gaps = 25/371 (6%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEAR---- 56
           +RWVR D P R     +LLE VRLP +   Y L  VEA+ L+  C  C  LL EAR    
Sbjct: 203 LRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQA 262

Query: 57  ACFILGREAGALRTRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLP 116
           A +         R RPR    LAE++V++GGCD +   +L   D Y+P++ +W  L   P
Sbjct: 263 ARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCD-QDCDELVTVDCYNPQTGQWRYLAEFP 321

Query: 117 GYTRSEFAACALRNDVYVSGGHINSH---DVWMFSSHLHTWIKVASLHKGRWRHKMAVVQ 173
            +    ++  AL ND+YV+GG   S     VW ++S ++ W +VA + K R  H  +V+ 
Sbjct: 322 DHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLD 381

Query: 174 GQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGG 233
           G L+ V          S ERYD  +++W A  P+   + + +  +C G+L+ IG     G
Sbjct: 382 GLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSL--AG 432

Query: 234 VNTDKVQCFDPKEDRWSL-----RSPAPFSQRCLEAVSLEDTIYVMGGLMSKIFTYDPGT 288
             T  +QC+DP  D WSL       P  F+ +     +L   +Y +    +++  Y+P  
Sbjct: 433 KETMVMQCYDPDTDLWSLVDCGQLPPWSFAPK---TATLNGLMYFVRDDSAEVDVYNPTR 489

Query: 289 DVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQPSLQRC 348
           + W +   +        + V  GK+++ GG D+  E +D V  +DP +    V   L   
Sbjct: 490 NEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEP 549

Query: 349 TSSHGCVTIIQ 359
           T  HG V+I +
Sbjct: 550 TFWHGSVSIFR 560


>gi|40807500 kelch-like 20 [Homo sapiens]
          Length = 609

 Score =  154 bits (388), Expect = 2e-37
 Identities = 105/333 (31%), Positives = 167/333 (50%), Gaps = 18/333 (5%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           M WV++    RR QL ++L+HVRLPLL+P + +  V +D L+++  ECR L+ EA+   +
Sbjct: 236 MAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLL 295

Query: 61  LGREAGAL---RTRPRRFMDLAEVIVVIGG-CDRKGLLKLPFADAYHPESQRWTPLPSLP 116
           L +E   +   RTRPR+ +   EV+  +GG C    +  +   + Y P++  W  + S+ 
Sbjct: 296 LPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSV---ERYDPQTNEWRMVASM- 351

Query: 117 GYTRSEFAACALRNDVYVSGGHINS---HDVWMFSSHLHTWIK-VASLHKGRWRHKMAVV 172
              R       L + +Y  GGH  S   + V  +    + W   VA     R    +AV+
Sbjct: 352 SKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVL 411

Query: 173 QGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQG 232
            G L+AVGG DG+  L+ VERYDP  N W   A +       AVA   G L+ +GG+  G
Sbjct: 412 GGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGS-DG 470

Query: 233 GVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGL-----MSKIFTYDPG 287
               + V+ ++P+E+RW   +P    ++ L     +D IY +GG      +S    Y+P 
Sbjct: 471 TSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPR 530

Query: 288 TDVWGEAAVLPSPVESCGVTVCDGKVHILGGRD 320
           T+ W     + S     G+ V +G++  +GG D
Sbjct: 531 TNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFD 563



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 42/128 (32%), Positives = 65/128 (50%), Gaps = 8/128 (6%)

Query: 78  LAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRND-VYVSG 136
           L   +  +GG D  G   L   + Y+P+  RW  +   P  TR +   CA+  D +Y  G
Sbjct: 458 LGGFLYAVGGSD--GTSPLNTVERYNPQENRWHTIA--PMGTRRKHLGCAVYQDMIYAVG 513

Query: 137 GHINSHDVWM---FSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVER 193
           G  ++ ++     ++   + W  V ++   R    +AVV GQL AVGGFDG   L ++E 
Sbjct: 514 GRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEV 573

Query: 194 YDPFSNTW 201
           +DP +NTW
Sbjct: 574 FDPDANTW 581


>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
          Length = 709

 Score =  153 bits (387), Expect = 2e-37
 Identities = 107/356 (30%), Positives = 174/356 (48%), Gaps = 27/356 (7%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           + WVRHD   RR  L +LL ++RLPLLAP  FL  +E + L +   EC+ L++EA    +
Sbjct: 342 LTWVRHDLEQRRKDLSKLLAYIRLPLLAPQ-FLADMENNVLFRDDIECQKLIMEAMKYHL 400

Query: 61  LGREAGAL---RTRPRRFMDLAEVIVVIGGCDR-KGLLKLPFADAYHPESQRWTPLPSLP 116
           L      L   RT+PR+       +  +GG D  KG   +   + Y   +  WTP+ ++ 
Sbjct: 401 LPERRPMLQSPRTKPRK--STVGTLFAVGGMDSTKGATSI---EKYDLRTNMWTPVANMN 455

Query: 117 GYTRSEFAACALRNDVYVSGGHINS---HDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQ 173
           G  R +F    L + +YV GG       + V  ++    TW  +  +   R    +AV++
Sbjct: 456 G-RRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLE 514

Query: 174 GQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGG 233
           G ++AVGG DG   L++VER+DP +  W   A +    S+  VA  +GKL+ +GG R G 
Sbjct: 515 GPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG-RDGS 573

Query: 234 VNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG-----------LMSKIF 282
                V+CFDP  ++W+L +     +  +   +    +Y +GG           L   + 
Sbjct: 574 SCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVE 633

Query: 283 TYDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQ 338
            YDP TD+W   A +    ++ GV +   K++ +GG D +    + V  +DP + +
Sbjct: 634 RYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQA-YLNTVEAYDPQTNE 688



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 42/150 (28%), Positives = 64/150 (42%), Gaps = 12/150 (8%)

Query: 78  LAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGG 137
           L+  +  +GG D    LK    + + P + +WT L +     R           +Y  GG
Sbjct: 560 LSGKLYAVGGRDGSSCLKS--VECFDPHTNKWT-LCAQMSKRRGGVGVTTWNGLLYAIGG 616

Query: 138 HIN---------SHDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRL 188
           H           S  V  +      W  VAS+   R    + ++  +L+AVGG+DG   L
Sbjct: 617 HDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYL 676

Query: 189 HSVERYDPFSNTWAAAAPLPEAVSSAAVAS 218
           ++VE YDP +N W   APL    + A V +
Sbjct: 677 NTVEAYDPQTNEWTQVAPLCLGRAGACVVT 706


>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
          Length = 694

 Score =  153 bits (387), Expect = 2e-37
 Identities = 107/356 (30%), Positives = 174/356 (48%), Gaps = 27/356 (7%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           + WVRHD   RR  L +LL ++RLPLLAP  FL  +E + L +   EC+ L++EA    +
Sbjct: 327 LTWVRHDLEQRRKDLSKLLAYIRLPLLAPQ-FLADMENNVLFRDDIECQKLIMEAMKYHL 385

Query: 61  LGREAGAL---RTRPRRFMDLAEVIVVIGGCDR-KGLLKLPFADAYHPESQRWTPLPSLP 116
           L      L   RT+PR+       +  +GG D  KG   +   + Y   +  WTP+ ++ 
Sbjct: 386 LPERRPMLQSPRTKPRK--STVGTLFAVGGMDSTKGATSI---EKYDLRTNMWTPVANMN 440

Query: 117 GYTRSEFAACALRNDVYVSGGHINS---HDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQ 173
           G  R +F    L + +YV GG       + V  ++    TW  +  +   R    +AV++
Sbjct: 441 G-RRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLE 499

Query: 174 GQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGG 233
           G ++AVGG DG   L++VER+DP +  W   A +    S+  VA  +GKL+ +GG R G 
Sbjct: 500 GPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG-RDGS 558

Query: 234 VNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG-----------LMSKIF 282
                V+CFDP  ++W+L +     +  +   +    +Y +GG           L   + 
Sbjct: 559 SCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVE 618

Query: 283 TYDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQ 338
            YDP TD+W   A +    ++ GV +   K++ +GG D +    + V  +DP + +
Sbjct: 619 RYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQA-YLNTVEAYDPQTNE 673



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 42/150 (28%), Positives = 64/150 (42%), Gaps = 12/150 (8%)

Query: 78  LAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGG 137
           L+  +  +GG D    LK    + + P + +WT L +     R           +Y  GG
Sbjct: 545 LSGKLYAVGGRDGSSCLKS--VECFDPHTNKWT-LCAQMSKRRGGVGVTTWNGLLYAIGG 601

Query: 138 HIN---------SHDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRL 188
           H           S  V  +      W  VAS+   R    + ++  +L+AVGG+DG   L
Sbjct: 602 HDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYL 661

Query: 189 HSVERYDPFSNTWAAAAPLPEAVSSAAVAS 218
           ++VE YDP +N W   APL    + A V +
Sbjct: 662 NTVEAYDPQTNEWTQVAPLCLGRAGACVVT 691


>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
          Length = 755

 Score =  153 bits (387), Expect = 2e-37
 Identities = 107/356 (30%), Positives = 174/356 (48%), Gaps = 27/356 (7%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           + WVRHD   RR  L +LL ++RLPLLAP  FL  +E + L +   EC+ L++EA    +
Sbjct: 388 LTWVRHDLEQRRKDLSKLLAYIRLPLLAPQ-FLADMENNVLFRDDIECQKLIMEAMKYHL 446

Query: 61  LGREAGAL---RTRPRRFMDLAEVIVVIGGCDR-KGLLKLPFADAYHPESQRWTPLPSLP 116
           L      L   RT+PR+       +  +GG D  KG   +   + Y   +  WTP+ ++ 
Sbjct: 447 LPERRPMLQSPRTKPRK--STVGTLFAVGGMDSTKGATSI---EKYDLRTNMWTPVANMN 501

Query: 117 GYTRSEFAACALRNDVYVSGGHINS---HDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQ 173
           G  R +F    L + +YV GG       + V  ++    TW  +  +   R    +AV++
Sbjct: 502 G-RRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLE 560

Query: 174 GQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGG 233
           G ++AVGG DG   L++VER+DP +  W   A +    S+  VA  +GKL+ +GG R G 
Sbjct: 561 GPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGG-RDGS 619

Query: 234 VNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG-----------LMSKIF 282
                V+CFDP  ++W+L +     +  +   +    +Y +GG           L   + 
Sbjct: 620 SCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVE 679

Query: 283 TYDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQ 338
            YDP TD+W   A +    ++ GV +   K++ +GG D +    + V  +DP + +
Sbjct: 680 RYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQA-YLNTVEAYDPQTNE 734



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 42/150 (28%), Positives = 64/150 (42%), Gaps = 12/150 (8%)

Query: 78  LAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGG 137
           L+  +  +GG D    LK    + + P + +WT L +     R           +Y  GG
Sbjct: 606 LSGKLYAVGGRDGSSCLKS--VECFDPHTNKWT-LCAQMSKRRGGVGVTTWNGLLYAIGG 662

Query: 138 HIN---------SHDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRL 188
           H           S  V  +      W  VAS+   R    + ++  +L+AVGG+DG   L
Sbjct: 663 HDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYL 722

Query: 189 HSVERYDPFSNTWAAAAPLPEAVSSAAVAS 218
           ++VE YDP +N W   APL    + A V +
Sbjct: 723 NTVEAYDPQTNEWTQVAPLCLGRAGACVVT 752


>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
          Length = 505

 Score =  148 bits (374), Expect = 7e-36
 Identities = 111/371 (29%), Positives = 177/371 (47%), Gaps = 22/371 (5%)

Query: 3   WVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFILG 62
           WV HD   R+  + RL+EHVRLPLL   Y +++VE + L++    C+  L+EA    +L 
Sbjct: 138 WVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLP 197

Query: 63  REAGAL----RTRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGY 118
            E   L    RTR R  M+L +++VV+GG   K +  +   + Y  + +RW  +  LP  
Sbjct: 198 TEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSV---ECYDFKEERWHQVAELPS- 253

Query: 119 TRSEFAACALRNDVYVSGGHINSHDVWMFSSH---LHTWIKVASLHKGRWRHKMAVVQGQ 175
            R       +   V+  GG   S  V    S+      W  VA++   R     AV+ G 
Sbjct: 254 RRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGL 313

Query: 176 LFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIG---GARQG 232
           L+AVGGFDG   L SVE Y+  SN W   AP+    SS  V    G L+ +G   GA + 
Sbjct: 314 LYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQ 373

Query: 233 GVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG-----LMSKIFTYDPG 287
            ++T  V+C++   + W+  +     +       L + +Y +GG     +   +  YDP 
Sbjct: 374 CLST--VECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPT 431

Query: 288 TDVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQPSLQR 347
           T+ W + A +     + GV   +G ++++GG DD   +   V  ++P++ +  V  S   
Sbjct: 432 TNAWRQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPTTDKWTVVSSCMS 490

Query: 348 CTSSHGCVTII 358
              S+  VT+I
Sbjct: 491 TGRSYAGVTVI 501


>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
          Length = 597

 Score =  148 bits (374), Expect = 7e-36
 Identities = 111/371 (29%), Positives = 177/371 (47%), Gaps = 22/371 (5%)

Query: 3   WVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFILG 62
           WV HD   R+  + RL+EHVRLPLL   Y +++VE + L++    C+  L+EA    +L 
Sbjct: 230 WVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLP 289

Query: 63  REAGAL----RTRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGY 118
            E   L    RTR R  M+L +++VV+GG   K +  +   + Y  + +RW  +  LP  
Sbjct: 290 TEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSV---ECYDFKEERWHQVAELPS- 345

Query: 119 TRSEFAACALRNDVYVSGGHINSHDVWMFSSH---LHTWIKVASLHKGRWRHKMAVVQGQ 175
            R       +   V+  GG   S  V    S+      W  VA++   R     AV+ G 
Sbjct: 346 RRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGL 405

Query: 176 LFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIG---GARQG 232
           L+AVGGFDG   L SVE Y+  SN W   AP+    SS  V    G L+ +G   GA + 
Sbjct: 406 LYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQ 465

Query: 233 GVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG-----LMSKIFTYDPG 287
            ++T  V+C++   + W+  +     +       L + +Y +GG     +   +  YDP 
Sbjct: 466 CLST--VECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPT 523

Query: 288 TDVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQPSLQR 347
           T+ W + A +     + GV   +G ++++GG DD   +   V  ++P++ +  V  S   
Sbjct: 524 TNAWRQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPTTDKWTVVSSCMS 582

Query: 348 CTSSHGCVTII 358
              S+  VT+I
Sbjct: 583 TGRSYAGVTVI 593


>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
          Length = 593

 Score =  148 bits (374), Expect = 7e-36
 Identities = 111/371 (29%), Positives = 177/371 (47%), Gaps = 22/371 (5%)

Query: 3   WVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFILG 62
           WV HD   R+  + RL+EHVRLPLL   Y +++VE + L++    C+  L+EA    +L 
Sbjct: 226 WVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLP 285

Query: 63  REAGAL----RTRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGY 118
            E   L    RTR R  M+L +++VV+GG   K +  +   + Y  + +RW  +  LP  
Sbjct: 286 TEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSV---ECYDFKEERWHQVAELPS- 341

Query: 119 TRSEFAACALRNDVYVSGGHINSHDVWMFSSH---LHTWIKVASLHKGRWRHKMAVVQGQ 175
            R       +   V+  GG   S  V    S+      W  VA++   R     AV+ G 
Sbjct: 342 RRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGL 401

Query: 176 LFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIG---GARQG 232
           L+AVGGFDG   L SVE Y+  SN W   AP+    SS  V    G L+ +G   GA + 
Sbjct: 402 LYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQ 461

Query: 233 GVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG-----LMSKIFTYDPG 287
            ++T  V+C++   + W+  +     +       L + +Y +GG     +   +  YDP 
Sbjct: 462 CLST--VECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPT 519

Query: 288 TDVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQPSLQR 347
           T+ W + A +     + GV   +G ++++GG DD   +   V  ++P++ +  V  S   
Sbjct: 520 TNAWRQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPTTDKWTVVSSCMS 578

Query: 348 CTSSHGCVTII 358
              S+  VT+I
Sbjct: 579 TGRSYAGVTVI 589


>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
          Length = 589

 Score =  145 bits (366), Expect = 6e-35
 Identities = 107/340 (31%), Positives = 157/340 (46%), Gaps = 31/340 (9%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           ++WV+HD   R+  L  LL  VRL LL      E V ++ LL A    + ++ EA  C  
Sbjct: 215 LQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEALRCKT 274

Query: 61  LGREAGALRTRP-RRFMDLAEVIVVIGG----CDRKGLLKLPFADAYHPESQRWTPLPSL 115
              +   + T P  R       ++++GG    CD     K+   D    E      LPS 
Sbjct: 275 RILQNDGVVTSPCARPRKAGHTLLILGGQTFMCD-----KIYQVDHKAKEIIPKADLPS- 328

Query: 116 PGYTRSEFAACALRNDVYVSGGHIN----SHDVWMFSSHLHTWIKVASLHKGRWRHKMAV 171
               R EF+A A+   VYV+GG  +    S DVW++ +    W K A +   R+ H  A 
Sbjct: 329 ---PRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAE 385

Query: 172 VQGQLFAVGGFDGLR---------RLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGK 222
           ++  L+ VGG   L           L  VE+YDP +N W   APL + VS+AAV S   K
Sbjct: 386 LENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLK 445

Query: 223 LFVIGGARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG----LM 278
           LFV GG         KVQC+DP E+RW++++  P   R   A  L   I++MGG      
Sbjct: 446 LFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTA 505

Query: 279 SKIFTYDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGG 318
           +  + +D  T+ W     + +   SC       K++++GG
Sbjct: 506 ASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGG 545



 Score = 55.5 bits (132), Expect = 8e-08
 Identities = 42/151 (27%), Positives = 65/151 (43%), Gaps = 18/151 (11%)

Query: 203 AAAPLPEAVSSAAVASCAGKLFVIGG-ARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRC 261
           A  P P    SA+   C  K++V GG   + GV+ D V  +D   + WS  +P   ++  
Sbjct: 324 ADLPSPRKEFSASAIGC--KVYVTGGRGSENGVSKD-VWVYDTVHEEWSKAAPMLIARFG 380

Query: 262 LEAVSLEDTIYVMGGLMS--------------KIFTYDPGTDVWGEAAVLPSPVESCGVT 307
             +  LE+ +YV+GG  S              ++  YDPG + W   A L   V +  V 
Sbjct: 381 HGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVV 440

Query: 308 VCDGKVHILGGRDDRGESTDKVFTFDPSSGQ 338
               K+ + GG     +   KV  +DPS  +
Sbjct: 441 SAKLKLFVFGGTSIHRDMVSKVQCYDPSENR 471



 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 30/119 (25%), Positives = 51/119 (42%), Gaps = 3/119 (2%)

Query: 102 YHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGG--HINSHDVWMFSSHLHTWIKVAS 159
           Y P   RWT     P   R   AA  L + +++ GG     +   + F    + W ++  
Sbjct: 465 YDPSENRWTIKAECPQPWRYT-AAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGD 523

Query: 160 LHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVAS 218
           +   R          +L+ VGG+ G +R  +++ YDP S+TW     +P ++   A  S
Sbjct: 524 MTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVS 582



 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 43/171 (25%), Positives = 71/171 (41%), Gaps = 11/171 (6%)

Query: 94  LKLPFADAYHPESQRWTPL-PSLPGYTRSEFAACALRNDVYVSGGHINSHD----VWMFS 148
           + L   + Y P + +W  + P   G + +   +  L+  ++V GG     D    V  + 
Sbjct: 409 VSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLK--LFVFGGTSIHRDMVSKVQCYD 466

Query: 149 SHLHTWIKVASLHKGRWRHKMAVVQG-QLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPL 207
              + W   A   +  WR+  A V G Q+F +GG D      S  R+D  +N W     +
Sbjct: 467 PSENRWTIKAECPQP-WRYTAAAVLGSQIFIMGG-DTEFTAASAYRFDCETNQWTRIGDM 524

Query: 208 PEAVSSAAVASCAGKLFVIGGARQGGVNTDKVQCFDPKEDRWSLRSPAPFS 258
                S    +   KL+V+GG   G      + C+DP  D W+  +  P+S
Sbjct: 525 TAKRMSCHALASGNKLYVVGGYF-GTQRCKTLDCYDPTSDTWNCITTVPYS 574


>gi|128485503 kelch-like 30 [Homo sapiens]
          Length = 560

 Score =  142 bits (359), Expect = 4e-34
 Identities = 96/339 (28%), Positives = 162/339 (47%), Gaps = 38/339 (11%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           MRWVRHD  AR   L  LL  V L  +      + + ++ L+Q    CR  L +      
Sbjct: 183 MRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQ------ 236

Query: 61  LGREAGALRTRPRRFMDLAEVIVVIGGCDRK----------GLLKLPFADAYHPESQRWT 110
            G +   L  + +    L EV+VV+GG   +          GL    F   Y+ +++RW 
Sbjct: 237 -GHDGAPLALQQK----LEEVLVVVGGQALEEEEAGEEPTPGLGNFAF---YNSKAKRWM 288

Query: 111 PLPSLPGYTRSEFAACALRNDVYVSGGHINSH-------DVWMFSSHLHTWIKVASLHKG 163
            LP  P Y +  F+  AL N++YV+GG   +          W F     +W  VA + K 
Sbjct: 289 ALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKP 348

Query: 164 RWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKL 223
           R  H  A + G+++ +GG      +  VE YDP++++W   +P  + VS+ + A C G+L
Sbjct: 349 RTNHASAALNGEIYVIGGTT--LDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRL 406

Query: 224 FVIGGARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEA---VSLEDTIYVMGGLMSK 280
           +++G +     N   +QC++P  D WS+ + +PF  + L +    +L   +Y++G    K
Sbjct: 407 YLVGSS-ACKYNALALQCYNPVTDAWSVIA-SPFLPKYLSSPRCAALHGELYLIGDNTKK 464

Query: 281 IFTYDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGGR 319
           ++ YDPG ++W +     S  E+  +      +++ GGR
Sbjct: 465 VYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGR 503



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 46/182 (25%), Positives = 77/182 (42%), Gaps = 17/182 (9%)

Query: 82  IVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGGHI-- 139
           I VIGG      L +   ++Y P +  WTP+     Y  S F+A   R  +Y+ G     
Sbjct: 361 IYVIGGTT----LDVVEVESYDPYTDSWTPVSPALKYV-SNFSAAGCRGRLYLVGSSACK 415

Query: 140 -NSHDVWMFSSHLHTWIKVAS--LHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDP 196
            N+  +  ++     W  +AS  L K     + A + G+L+ +G  D  ++++    YDP
Sbjct: 416 YNALALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIG--DNTKKVYV---YDP 470

Query: 197 FSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQG--GVNTDKVQCFDPKEDRWSLRSP 254
            +N W           + A+      L+V GG  QG  G    +++ +D   D W+    
Sbjct: 471 GANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTWTRHGA 530

Query: 255 AP 256
            P
Sbjct: 531 LP 532


>gi|38194229 kelch-like 17 [Homo sapiens]
          Length = 642

 Score =  142 bits (357), Expect = 6e-34
 Identities = 100/351 (28%), Positives = 167/351 (47%), Gaps = 20/351 (5%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           + WV+HD  ARR  + RL++ VRLPLL+  + L  V+A+ L++   +C+ LL+EA    +
Sbjct: 260 LSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHL 319

Query: 61  LGREAGAL---RTRPRRFMDLAEVIVVIGGCDRKGLLKLPFAD--AYHPESQRWTPLPSL 115
           L  + G L   RTRPRR      V+  +GG    G L     D  AY   + RW  + S+
Sbjct: 320 LPEQRGVLGTSRTRPRRCEGAGPVLFAVGG----GSLFAIHGDCEAYDTRTDRWHVVASM 375

Query: 116 PGYTRSEFAACALRNDVYVSGGHINSHDVWMFSSH---LHTWIKVASLHKGRWRHKMAVV 172
               R+     A+ N +Y  GG+  + D+    S+    +TW    S+   R    +A +
Sbjct: 376 -STRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAAL 434

Query: 173 QGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQG 232
            G L++ GG+DG   L+S ERYDP + TW + A +        VA+  G L+ +GG    
Sbjct: 435 HGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGG-YDS 493

Query: 233 GVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG-----LMSKIFTYDPG 287
             +   V+ ++P+ + WS  +     +       LE  +YV GG      ++ +  Y P 
Sbjct: 494 SSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPK 553

Query: 288 TDVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQ 338
              W   A +     +  +   DG ++ +GG +D   S + +  ++P + +
Sbjct: 554 AGAWESVAPMNIRRSTHDLVAMDGWLYAVGG-NDGSSSLNSIEKYNPRTNK 603


>gi|166235129 kelch-like 3 [Homo sapiens]
          Length = 587

 Score =  141 bits (355), Expect = 1e-33
 Identities = 104/371 (28%), Positives = 171/371 (46%), Gaps = 22/371 (5%)

Query: 3   WVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFILG 62
           W+ ++   R   + +L+EHVRLPLL   Y ++ VE + L++    C+  L+EA    +L 
Sbjct: 220 WINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLP 279

Query: 63  REAGAL----RTRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGY 118
            +   L    RT+PR  + L +V++V+GG   K +  +   + Y  E  RW  +  LP  
Sbjct: 280 LDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSV---ECYDFEEDRWDQIAELPS- 335

Query: 119 TRSEFAACALRNDVYVSGGHINS---HDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQ 175
            R       +   VY  GG   S     V ++      W  +AS+ + R     AV+   
Sbjct: 336 RRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDL 395

Query: 176 LFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIG---GARQG 232
           L+AVGGFDG   L SVE Y   +N W   AP+    SS  V    GKL+ +G   GA + 
Sbjct: 396 LYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQ 455

Query: 233 GVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG-----LMSKIFTYDPG 287
            ++T  V+ ++P  + W   +     +       L   +Y  GG     +   +  YDPG
Sbjct: 456 CLST--VEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPG 513

Query: 288 TDVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQPSLQR 347
           T+ W + A +     + GV   +G ++++GG DD   +   V  ++P + +  + P+   
Sbjct: 514 TNTWKQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPVTDKWTLLPTNMS 572

Query: 348 CTSSHGCVTII 358
              S+  V +I
Sbjct: 573 TGRSYAGVAVI 583


>gi|11056006 kelch-like 12 [Homo sapiens]
          Length = 568

 Score =  137 bits (346), Expect = 1e-32
 Identities = 102/365 (27%), Positives = 174/365 (47%), Gaps = 24/365 (6%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           + WV+H    R   L  LL++VR+PLL P Y  + ++A+  ++   +CR L+ EA+   +
Sbjct: 201 INWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHL 260

Query: 61  ---LGREAGALRTRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPG 117
              L  +    RTR R  +   EV++V+GG   +    +   + Y P++Q W+ LPS+  
Sbjct: 261 RPELRSQMQGPRTRAR--LGANEVLLVVGGFGSQ-QSPIDVVEKYDPKTQEWSFLPSIT- 316

Query: 118 YTRSEFAACALRNDVYVSGGH-----INSHDVWMFSSHLH-TWIKVASLHKGRWRHKMAV 171
             R   A+ +L + +YV GG+     ++S +   +++     W  VA ++  R       
Sbjct: 317 RKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATT 376

Query: 172 VQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQ 231
           +   ++  GGFDG RR  S+ERYDP  + W+    +  A   A +   +G ++ +GG   
Sbjct: 377 LGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGG--Y 434

Query: 232 GGVN-TDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGL-----MSKIFTYD 285
            G+N  + V+ +DP    W+  +P    +       L D IYV+GG      +S +  Y+
Sbjct: 435 DGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYN 494

Query: 286 PGTDVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQPSL 345
             TD W     + +P    G TV  G+++ + G D        +  +DP     EV  S+
Sbjct: 495 IRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDG-NSLLSSIECYDPIIDSWEVVTSM 553

Query: 346 --QRC 348
             QRC
Sbjct: 554 GTQRC 558


>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
           sapiens]
          Length = 589

 Score =  136 bits (342), Expect = 3e-32
 Identities = 101/340 (29%), Positives = 153/340 (45%), Gaps = 31/340 (9%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           + W+ +D   R   L  LL+ VRL LL   Y +E V  +EL+    + + ++ EA  C +
Sbjct: 215 INWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKL 274

Query: 61  -LGREAGALRTRPRRFMDLAEVIVVIGG----CDRKGLLKLPFADAYHPESQRWTPLPSL 115
            + +  G + +   R       + ++GG    CD     KL   D    E      +PS 
Sbjct: 275 KILQNDGVVTSLCARPRKTGHALFLLGGQTFMCD-----KLYLVDQKAKEIIPKADIPS- 328

Query: 116 PGYTRSEFAACALRNDVYVSGGHIN----SHDVWMFSSHLHTWIKVASLHKGRWRHKMAV 171
               R EF+ACA+   VY++GG  +    S DVW++ +    W K A +   R+ H  A 
Sbjct: 329 ---PRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAE 385

Query: 172 VQGQLFAVGGFDGLR---------RLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGK 222
           ++  L+ VGG               L  VE YDP  N W   APL E VS+AAV S   K
Sbjct: 386 LKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLK 445

Query: 223 LFVIGGARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG----LM 278
           LF  GG         KVQC+D  E+RW++ +  P   R   A  L + I++MGG      
Sbjct: 446 LFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSA 505

Query: 279 SKIFTYDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGG 318
              + ++  T  W +   + +   SC       K++++GG
Sbjct: 506 CSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGG 545



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 34/126 (26%), Positives = 57/126 (45%), Gaps = 3/126 (2%)

Query: 95  KLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGG--HINSHDVWMFSSHLH 152
           KLP    Y     RWT   + P   R   AA  L N +++ GG    ++   + F+S  +
Sbjct: 458 KLPKVQCYDQCENRWTVPATCPQPWRYT-AAAVLGNQIFIMGGDTEFSACSAYKFNSETY 516

Query: 153 TWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVS 212
            W KV  +   R          +L+ VGG+ G++R  +++ YDP  + W +   +P ++ 
Sbjct: 517 QWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTVPYSLI 576

Query: 213 SAAVAS 218
             A  S
Sbjct: 577 PTAFVS 582



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 36/146 (24%), Positives = 58/146 (39%), Gaps = 18/146 (12%)

Query: 203 AAAPLPEAVSSAAVASCAGKLFVIGG-ARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRC 261
           A  P P    SA    C  K+++ GG   + GV+ D V  +D   + WS  +P   ++  
Sbjct: 324 ADIPSPRKEFSACAIGC--KVYITGGRGSENGVSKD-VWVYDTLHEEWSKAAPMLVARFG 380

Query: 262 LEAVSLEDTIYVMGG--------------LMSKIFTYDPGTDVWGEAAVLPSPVESCGVT 307
             +  L+  +YV+GG               + ++  YDP  + W   A L   V +  V 
Sbjct: 381 HGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVV 440

Query: 308 VCDGKVHILGGRDDRGESTDKVFTFD 333
               K+   GG     +   KV  +D
Sbjct: 441 SAKLKLFAFGGTSVSHDKLPKVQCYD 466


>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
          Length = 720

 Score =  135 bits (339), Expect = 7e-32
 Identities = 98/338 (28%), Positives = 155/338 (45%), Gaps = 26/338 (7%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           M+WV HD   R+G+L  LL ++RLPLL P   L  +E   +     EC+ LL+EA    +
Sbjct: 350 MQWVGHDVQNRQGELGMLLSYIRLPLL-PPQLLADLETSSMFTGDLECQKLLMEAMKYHL 408

Query: 61  LGREAGAL---RTRPRRFMDLAEVIVVIGGCD-RKGLLKLPFADAYHPESQRWTPLPSLP 116
           L      +   RT+PR+       +  +GG D  KG   +   + Y   +  W  + ++ 
Sbjct: 409 LPERRSMMQSPRTKPRK--STVGALYAVGGMDAMKGTTTI---EKYDLRTNSWLHIGTMN 463

Query: 117 GYTRSEFAACALRNDVYVSGGH---INSHDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQ 173
           G  R +F    + N +YV GG       + V  F+     W  +  +   R    +A ++
Sbjct: 464 G-RRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLE 522

Query: 174 GQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGG 233
           G ++AVGG DG   L++VER+DP    W   A +    S+  V +   KL+ IGG R G 
Sbjct: 523 GPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGG-RDGS 581

Query: 234 VNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG-----------LMSKIF 282
                ++ FDP  ++WSL +P    +  +   +    +YV+GG           L   + 
Sbjct: 582 SCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVE 641

Query: 283 TYDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGGRD 320
            YDP  D W   A L  P ++  V     K++++GG D
Sbjct: 642 RYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYD 679



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 51/171 (29%), Positives = 84/171 (49%), Gaps = 9/171 (5%)

Query: 174 GQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGG 233
           G L+AVGG D ++   ++E+YD  +N+W     +        VA    KL+V+GG R G 
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGG-RDGL 487

Query: 234 VNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG-----LMSKIFTYDPGT 288
              + V+CF+P    W++  P    +  L   +LE  +Y +GG      ++ +  +DP  
Sbjct: 488 KTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEG 547

Query: 289 DVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFT-FDPSSGQ 338
             W   A + +P  + GV   + K++ +GGRD  G S  K    FDP + +
Sbjct: 548 RQWNYVASMSTPRSTVGVVALNNKLYAIGGRD--GSSCLKSMEYFDPHTNK 596



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 53/174 (30%), Positives = 77/174 (44%), Gaps = 13/174 (7%)

Query: 85  IGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGGHINSH-- 142
           +GG D  G   L   + + PE ++W  + S+    RS     AL N +Y  GG   S   
Sbjct: 528 VGGHD--GWSYLNTVERWDPEGRQWNYVASM-STPRSTVGVVALNNKLYAIGGRDGSSCL 584

Query: 143 -DVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHS------VERYD 195
             +  F  H + W   A + K R    +A   G L+ VGG D     H       VERYD
Sbjct: 585 KSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYD 644

Query: 196 PFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVNTDKVQCFDPKEDRW 249
           P  ++W+  APL     + AV     KL+V+GG   G    + V+ +D + + W
Sbjct: 645 PKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG-YDGHTYLNTVESYDAQRNEW 697


>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
          Length = 718

 Score =  135 bits (339), Expect = 7e-32
 Identities = 98/338 (28%), Positives = 155/338 (45%), Gaps = 26/338 (7%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           M+WV HD   R+G+L  LL ++RLPLL P   L  +E   +     EC+ LL+EA    +
Sbjct: 350 MQWVGHDVQNRQGELGMLLSYIRLPLL-PPQLLADLETSSMFTGDLECQKLLMEAMKYHL 408

Query: 61  LGREAGAL---RTRPRRFMDLAEVIVVIGGCD-RKGLLKLPFADAYHPESQRWTPLPSLP 116
           L      +   RT+PR+       +  +GG D  KG   +   + Y   +  W  + ++ 
Sbjct: 409 LPERRSMMQSPRTKPRK--STVGALYAVGGMDAMKGTTTI---EKYDLRTNSWLHIGTMN 463

Query: 117 GYTRSEFAACALRNDVYVSGGH---INSHDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQ 173
           G  R +F    + N +YV GG       + V  F+     W  +  +   R    +A ++
Sbjct: 464 G-RRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLE 522

Query: 174 GQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGG 233
           G ++AVGG DG   L++VER+DP    W   A +    S+  V +   KL+ IGG R G 
Sbjct: 523 GPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGG-RDGS 581

Query: 234 VNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG-----------LMSKIF 282
                ++ FDP  ++WSL +P    +  +   +    +YV+GG           L   + 
Sbjct: 582 SCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVE 641

Query: 283 TYDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGGRD 320
            YDP  D W   A L  P ++  V     K++++GG D
Sbjct: 642 RYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYD 679



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 51/171 (29%), Positives = 84/171 (49%), Gaps = 9/171 (5%)

Query: 174 GQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGG 233
           G L+AVGG D ++   ++E+YD  +N+W     +        VA    KL+V+GG R G 
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGG-RDGL 487

Query: 234 VNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG-----LMSKIFTYDPGT 288
              + V+CF+P    W++  P    +  L   +LE  +Y +GG      ++ +  +DP  
Sbjct: 488 KTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEG 547

Query: 289 DVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFT-FDPSSGQ 338
             W   A + +P  + GV   + K++ +GGRD  G S  K    FDP + +
Sbjct: 548 RQWNYVASMSTPRSTVGVVALNNKLYAIGGRD--GSSCLKSMEYFDPHTNK 596



 Score = 75.5 bits (184), Expect = 7e-14
 Identities = 57/194 (29%), Positives = 83/194 (42%), Gaps = 15/194 (7%)

Query: 85  IGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGGHINSH-- 142
           +GG D  G   L   + + PE ++W  + S+    RS     AL N +Y  GG   S   
Sbjct: 528 VGGHD--GWSYLNTVERWDPEGRQWNYVASM-STPRSTVGVVALNNKLYAIGGRDGSSCL 584

Query: 143 -DVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHS------VERYD 195
             +  F  H + W   A + K R    +A   G L+ VGG D     H       VERYD
Sbjct: 585 KSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYD 644

Query: 196 PFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVNTDKVQCFDPKEDRWSLRSPA 255
           P  ++W+  APL     + AV     KL+V+GG   G    + V+ +D + + W    P 
Sbjct: 645 PKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG-YDGHTYLNTVESYDAQRNEWKEEVPV 703

Query: 256 PFSQ--RCLEAVSL 267
              +   C+  V L
Sbjct: 704 NIGRAGACVVVVKL 717


>gi|14780904 kelch-like 1 protein [Homo sapiens]
          Length = 748

 Score =  134 bits (338), Expect = 1e-31
 Identities = 102/377 (27%), Positives = 176/377 (46%), Gaps = 28/377 (7%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           M WV++D  +R   L  LL  +RLPLL P   L  +E   L +   EC+ L+LEA    +
Sbjct: 380 MMWVKYDMQSRCNDLSMLLAFIRLPLLPPQ-ILADLENHALFKNDLECQKLILEAMKYHL 438

Query: 61  LGREAGAL---RTRPRRFMDLAEVIVVIGGCDR-KGLLKLPFADAYHPESQRWTPLPSLP 116
           L      +   RT+PR+       +  +GG D  KG   +   + Y   +  W     + 
Sbjct: 439 LPERRTLMQSPRTKPRK--STVGTLYAVGGMDNNKGATTI---EKYDLRTNLWIQAGMMN 493

Query: 117 GYTRSEFAACALRNDVYVSGGHINS---HDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQ 173
           G  R +F    + + ++V GG       + V  ++    TW  +  +   R    + V++
Sbjct: 494 G-RRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLE 552

Query: 174 GQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGG 233
           G ++AVGG DG   L++VER+DP S  W   A +  A S+  VA+  GKL+ +GG R G 
Sbjct: 553 GPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGG-RDGS 611

Query: 234 VNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG-----------LMSKIF 282
                ++ +DP  ++W++ +P    +  +   + +  +Y +GG           L+  + 
Sbjct: 612 SCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVE 671

Query: 283 TYDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQ 342
            YDP TD W   A L  P ++ GV +   +++ +GG D +    + + ++DP + +    
Sbjct: 672 RYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQ-TYLNTMESYDPQTNEWTQM 730

Query: 343 PSLQRCTSSHGCVTIIQ 359
            SL     +  CV +I+
Sbjct: 731 ASL-NIGRAGACVVVIK 746


>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
          Length = 571

 Score =  134 bits (338), Expect = 1e-31
 Identities = 103/357 (28%), Positives = 159/357 (44%), Gaps = 34/357 (9%)

Query: 3   WVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFILG 62
           W+++D   R+  L +LL  VRLPLL+  +     EA+ L++    C+ LL EA     + 
Sbjct: 205 WIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFMP 264

Query: 63  REA----GALRTRPRRFMDLAEVIVVIGGCDRKGLLK-LPFADAYHPESQRWTPLPSLPG 117
                    L TRPR      +V+  +GG  + GL   L   + Y P++  W  L  L  
Sbjct: 265 EHRLSHQTVLMTRPRC---APKVLCAVGG--KSGLFACLDSVEMYFPQNDSWIGLAPL-N 318

Query: 118 YTRSEFAACALRNDVYVSGG-------------HINSHDVWMFSSHLHTWIKVASLHKGR 164
             R EF  C L   VYV GG             H NS + W  +   +TW  +  +++ R
Sbjct: 319 IPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECW--NPDTNTWTSLERMNESR 376

Query: 165 WRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLF 224
               + V+ G+L+A+GG+DG   L SVE+Y P    W   AP+    S  A A   G ++
Sbjct: 377 STLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIY 436

Query: 225 VIGGARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGG-----LMS 279
            IGG   G  + + V+ +DP +D W + +     +       +   I+V+GG      +S
Sbjct: 437 AIGG--YGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLS 494

Query: 280 KIFTYDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSS 336
            I  YDP  + W     +  P    G  V D  ++++GG        + V  +DP S
Sbjct: 495 SIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSG-SSYLNTVQKYDPIS 550



 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 57/174 (32%), Positives = 85/174 (48%), Gaps = 6/174 (3%)

Query: 78  LAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGG 137
           LA  +  +GG D +  L+    + Y P+ ++W P+  +   TRS FAA  L   +Y  GG
Sbjct: 384 LAGELYALGGYDGQSYLQS--VEKYIPKIRKWQPVAPMTT-TRSCFAAAVLDGMIYAIGG 440

Query: 138 HINSH--DVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYD 195
           +  +H   V  +     +W  VAS+   R    + V+ G +F VGG +G+  L S+ERYD
Sbjct: 441 YGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYD 500

Query: 196 PFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVNTDKVQCFDPKEDRW 249
           P  N W    P+ E  +    A     L+V+GG   G    + VQ +DP  D W
Sbjct: 501 PHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGG-HSGSSYLNTVQKYDPISDTW 553



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 36/128 (28%), Positives = 57/128 (44%), Gaps = 7/128 (5%)

Query: 81  VIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGGHIN 140
           +I  IGG    G   +   + Y P    W  + S+    R  F    +   ++V GGH  
Sbjct: 434 MIYAIGGY---GPAHMNSVERYDPSKDSWEMVASMAD-KRIHFGVGVMLGFIFVVGGHNG 489

Query: 141 -SH--DVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPF 197
            SH   +  +  H + W     + + R     AV+   L+ VGG  G   L++V++YDP 
Sbjct: 490 VSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPI 549

Query: 198 SNTWAAAA 205
           S+TW  +A
Sbjct: 550 SDTWLDSA 557


>gi|148664209 kelch-like 10 [Homo sapiens]
          Length = 608

 Score =  126 bits (317), Expect = 3e-29
 Identities = 88/335 (26%), Positives = 159/335 (47%), Gaps = 25/335 (7%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEA-RACF 59
           ++W+ HD   R+  +  LL  VRL L+   YF+  V+ ++ ++   EC+P+++ A +A +
Sbjct: 208 LKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMY 267

Query: 60  ILGREAGALR------TRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLP 113
            L     +        TRPR  +  A ++  IGG    G       +AY   + RW  + 
Sbjct: 268 DLNMNGPSNSDFTNPLTRPR--LPYA-ILFAIGGWS--GGSPTNAIEAYDARADRWVNVT 322

Query: 114 SLPGYTRSEFAACALRNDVYVSGG-----HINSHDVWMFSSHLHTWIKVASLHKGRWRHK 168
                 R+   A  L+  VY+ GG     + NS  V  F     TW +VA +H  R    
Sbjct: 323 CEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNS--VKRFDPVKKTWHQVAPMHSRRCYVS 380

Query: 169 MAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGG 228
           + V+   ++A+GGFDG  RL++ ERY+P +N W   AP+ E  S A+  +  GK+++ GG
Sbjct: 381 VTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGG 440

Query: 229 ARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGL-----MSKIFT 283
              G       + ++ + ++W++ +P    +  +  ++  + +Y +GG      +     
Sbjct: 441 F-NGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEA 499

Query: 284 YDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGG 318
           Y P  + W     + +P  + G+ V D  + ++GG
Sbjct: 500 YSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGG 534



 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 54/175 (30%), Positives = 85/175 (48%), Gaps = 7/175 (4%)

Query: 78  LAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGG 137
           L   I  +GG D  G ++L  A+ Y PE+ +WT +  +    RS+ +A  L   VY+ GG
Sbjct: 384 LGNFIYAMGGFD--GYVRLNTAERYEPETNQWTLIAPMHEQ-RSDASATTLYGKVYICGG 440

Query: 138 HINSHDVW---MFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERY 194
              +  ++   ++++  + W  +A +   R    +      ++AVGGFDG  RL S E Y
Sbjct: 441 FNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAY 500

Query: 195 DPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVNTDKVQCFDPKEDRW 249
            P +NTW     +    S+  +      LFV+GG   G   T  V+C+D K D W
Sbjct: 501 SPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFN-GFTTTFNVECYDEKTDEW 554



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 34/124 (27%), Positives = 57/124 (45%), Gaps = 6/124 (4%)

Query: 99  ADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGGHINSH---DVWMFSSHLHTWI 155
           A+ Y+ ES +WT +  +    RS     A    VY  GG   ++       +S   +TW 
Sbjct: 450 AEVYNTESNQWTVIAPMRS-RRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWR 508

Query: 156 KVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAA 215
            + ++   R    + VV   LF VGGF+G     +VE YD  ++ W  A  +  ++  +A
Sbjct: 509 TIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDM--SIYRSA 566

Query: 216 VASC 219
           ++ C
Sbjct: 567 LSCC 570



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 7/104 (6%)

Query: 223 LFVIGGARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCLE-AVSLEDTIYVMGGLMS-- 279
           LF IGG   GG  T+ ++ +D + DRW   +    S R    A  L+  +Y++GG  S  
Sbjct: 293 LFAIGGW-SGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVD 351

Query: 280 ---KIFTYDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGGRD 320
               +  +DP    W + A + S      VTV    ++ +GG D
Sbjct: 352 YFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFD 395


>gi|55925604 kelch-like 18 [Homo sapiens]
          Length = 574

 Score =  124 bits (312), Expect = 1e-28
 Identities = 93/348 (26%), Positives = 144/348 (41%), Gaps = 59/348 (16%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           + WVR+D   R   L  LL ++RLPL  P +  ++V+ D+L++ C +CR L+ EA+   +
Sbjct: 206 LAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHL 265

Query: 61  LGREAG---ALRTRPRRFMDLAEVIVVIGGCDRKG------------------------- 92
           +        A RTRPR    +A +I  +GG +  G                         
Sbjct: 266 MPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTA 325

Query: 93  ---------------------LLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRND 131
                                 L+L   +AY+PE+  WT + S+    RS      L   
Sbjct: 326 RSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNS-KRSAMGTVVLDGQ 384

Query: 132 VYVSGGHINSHD---VWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRL 188
           +YV GG+  +     V  +S     W  V S+   R    + V +G+++  GG DGL+  
Sbjct: 385 IYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIF 444

Query: 189 HSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVNTDKVQCFDPKEDR 248
            SVE Y+  + TW  AA +         AS   K+FV GG    G      + +    D+
Sbjct: 445 SSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGF-LSIAEMYSSVADQ 503

Query: 249 WSLRSPAPFSQRCLEAVSLEDTIYVMGGL-----MSKIFTYDPGTDVW 291
           W L  P    +  +  V+    +Y +GG      +S +  YDP TD W
Sbjct: 504 WCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCW 551



 Score = 88.6 bits (218), Expect = 8e-18
 Identities = 53/176 (30%), Positives = 80/176 (45%), Gaps = 7/176 (3%)

Query: 82  IVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGGHINS 141
           I V GG D  G   L   + Y PE+ +WT + S+    RS          +YVSGGH   
Sbjct: 385 IYVCGGYD--GNSSLSSVETYSPETDKWTVVTSMSS-NRSAAGVTVFEGRIYVSGGHDGL 441

Query: 142 H---DVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFS 198
                V  ++ H  TW   A +   R RH  A +  ++F  GG+DG   L   E Y   +
Sbjct: 442 QIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVA 501

Query: 199 NTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVNTDKVQCFDPKEDRWSLRSP 254
           + W    P+    S  ++ +  G+L+ +GG   G  N   V+ +DP+ D W+  +P
Sbjct: 502 DQWCLIVPMHTRRSRVSLVASCGRLYAVGGY-DGQSNLSSVEMYDPETDCWTFMAP 556



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 42/129 (32%), Positives = 62/129 (48%), Gaps = 6/129 (4%)

Query: 82  IVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGGHINS 141
           I V GG D  GL      + Y+  +  W P   +    R    A +L + ++V GG+  S
Sbjct: 432 IYVSGGHD--GLQIFSSVEHYNHHTATWHPAAGMLN-KRCRHGAASLGSKMFVCGGYDGS 488

Query: 142 HDVW---MFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFS 198
             +    M+SS    W  +  +H  R R  +    G+L+AVGG+DG   L SVE YDP +
Sbjct: 489 GFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPET 548

Query: 199 NTWAAAAPL 207
           + W   AP+
Sbjct: 549 DCWTFMAPM 557


>gi|194097389 kelch-like 38 [Homo sapiens]
          Length = 581

 Score =  124 bits (310), Expect = 2e-28
 Identities = 101/381 (26%), Positives = 166/381 (43%), Gaps = 34/381 (8%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEAR---- 56
           M W++HD  AR+  ++ L + VRL  + PA+F   +  D LLQ+   C+ +L  A+    
Sbjct: 201 MVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQIILETAKRQMF 260

Query: 57  -ACFILGREAGALRTRPRRFMDLAEVIVVIGG------CDRKGLLKLPFADAYHPESQRW 109
             C     +   L   P R     + ++++GG        R  LL       Y  ++ +W
Sbjct: 261 SLCGTTVPDCKLLLHVPPR-NSYQDFLILLGGRKDSQQTTRDVLL-------YSKQTGQW 312

Query: 110 TPLPSLPGYTR-SEFAACALRNDVYVSGG-------HINSHDVWMFSSHLHTWIKVASLH 161
             L  LP  TR  + +A  L   +YV GG        + SH+V++FS  L+ W     + 
Sbjct: 313 QSLAKLP--TRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLGEPML 370

Query: 162 KGRWRHKMAVVQGQLFAVGGF-DGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCA 220
             R+ H+    +  +F++GG  +G   + S+ERYD   N W + A +P  V   AVA   
Sbjct: 371 VARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVKD 430

Query: 221 GKLFVIGGARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGLMSK 280
            +L++ GG          +Q +    + W           C  AV L + I ++GG   +
Sbjct: 431 QRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGGYTRR 490

Query: 281 IFTYDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGGR----DDRGESTDKVFTFDPSS 336
           I  YDP ++ + + A +       G TV   K+++ GGR    D   E +     +DP +
Sbjct: 491 ILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSASFDCYDPET 550

Query: 337 GQVEVQPSLQRCTSSHGCVTI 357
                Q  L      H C+T+
Sbjct: 551 DTWTSQGQLPHKLFDHACLTL 571


>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
          Length = 624

 Score =  122 bits (305), Expect = 7e-28
 Identities = 94/348 (27%), Positives = 152/348 (43%), Gaps = 21/348 (6%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           + WV++D   RR  ++ LL  VR   L P +   +++  E+LQ+   C+  L++      
Sbjct: 250 INWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELT 309

Query: 61  LGREAGALRTRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTR 120
           L +    +   P R   +  +I   GG  R+ L    + +AY+P    W  L  L    R
Sbjct: 310 LHKPTQVM---PCRAPKVGRLIYTAGGYFRQSL---SYLEAYNPSDGTWLRLADLQ-VPR 362

Query: 121 SEFAACALRNDVYVSGGHINSHDVWMFSSHL-------HTWIKVASLHKGRWRHKMAVVQ 173
           S  A C +   +Y  GG  NS D    SS L       + W   A +   R R  + V+ 
Sbjct: 363 SGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVID 422

Query: 174 GQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGG 233
           G ++AVGG  G    +SVERY+P  + W   AP+        VA     L+ +GG   G 
Sbjct: 423 GHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGF-DGT 481

Query: 234 VNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGL-----MSKIFTYDPGT 288
              +  +C+ P+ + W + +     +       L + IY  GG      ++ +  YD  T
Sbjct: 482 NRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVET 541

Query: 289 DVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSS 336
           + W   A +     + G+TV  G++++LGG D      D V  +DP +
Sbjct: 542 ETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGH-TFLDSVECYDPDT 588



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 51/175 (29%), Positives = 82/175 (46%), Gaps = 13/175 (7%)

Query: 82  IVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDV-YVSGG--- 137
           I  +GG    G +     + Y PE   W  +   P  TR      A+ N + Y  GG   
Sbjct: 425 IYAVGGSH--GCIHHNSVERYEPERDEWHLVA--PMLTRRIGVGVAVLNRLLYAVGGFDG 480

Query: 138 --HINSHDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYD 195
              +NS + +      + W  + +++  R    + V+   ++A GG+DG  +L+SVERYD
Sbjct: 481 TNRLNSAECYY--PERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYD 538

Query: 196 PFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVNTDKVQCFDPKEDRWS 250
             + TW   AP+    S+  +    G+++V+GG   G    D V+C+DP  D WS
Sbjct: 539 VETETWTFVAPMKHRRSALGITVHQGRIYVLGG-YDGHTFLDSVECYDPDTDTWS 592



 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 44/143 (30%), Positives = 69/143 (48%), Gaps = 6/143 (4%)

Query: 78  LAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGG 137
           L  ++  +GG D  G  +L  A+ Y+PE   W  + ++    RS    C L N +Y +GG
Sbjct: 468 LNRLLYAVGGFD--GTNRLNSAECYYPERNEWRMITAM-NTIRSGAGVCVLHNCIYAAGG 524

Query: 138 HINS---HDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERY 194
           +      + V  +     TW  VA +   R    + V QG+++ +GG+DG   L SVE Y
Sbjct: 525 YDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECY 584

Query: 195 DPFSNTWAAAAPLPEAVSSAAVA 217
           DP ++TW+    +    S   VA
Sbjct: 585 DPDTDTWSEVTRMTSGRSGVGVA 607


>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
          Length = 624

 Score =  122 bits (305), Expect = 7e-28
 Identities = 94/348 (27%), Positives = 152/348 (43%), Gaps = 21/348 (6%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           + WV++D   RR  ++ LL  VR   L P +   +++  E+LQ+   C+  L++      
Sbjct: 250 INWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELT 309

Query: 61  LGREAGALRTRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTR 120
           L +    +   P R   +  +I   GG  R+ L    + +AY+P    W  L  L    R
Sbjct: 310 LHKPTQVM---PCRAPKVGRLIYTAGGYFRQSL---SYLEAYNPSDGTWLRLADLQ-VPR 362

Query: 121 SEFAACALRNDVYVSGGHINSHDVWMFSSHL-------HTWIKVASLHKGRWRHKMAVVQ 173
           S  A C +   +Y  GG  NS D    SS L       + W   A +   R R  + V+ 
Sbjct: 363 SGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVID 422

Query: 174 GQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGG 233
           G ++AVGG  G    +SVERY+P  + W   AP+        VA     L+ +GG   G 
Sbjct: 423 GHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGF-DGT 481

Query: 234 VNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGL-----MSKIFTYDPGT 288
              +  +C+ P+ + W + +     +       L + IY  GG      ++ +  YD  T
Sbjct: 482 NRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVET 541

Query: 289 DVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSS 336
           + W   A +     + G+TV  G++++LGG D      D V  +DP +
Sbjct: 542 ETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGH-TFLDSVECYDPDT 588



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 51/175 (29%), Positives = 82/175 (46%), Gaps = 13/175 (7%)

Query: 82  IVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDV-YVSGG--- 137
           I  +GG    G +     + Y PE   W  +   P  TR      A+ N + Y  GG   
Sbjct: 425 IYAVGGSH--GCIHHNSVERYEPERDEWHLVA--PMLTRRIGVGVAVLNRLLYAVGGFDG 480

Query: 138 --HINSHDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYD 195
              +NS + +      + W  + +++  R    + V+   ++A GG+DG  +L+SVERYD
Sbjct: 481 TNRLNSAECYY--PERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYD 538

Query: 196 PFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVNTDKVQCFDPKEDRWS 250
             + TW   AP+    S+  +    G+++V+GG   G    D V+C+DP  D WS
Sbjct: 539 VETETWTFVAPMKHRRSALGITVHQGRIYVLGG-YDGHTFLDSVECYDPDTDTWS 592



 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 44/143 (30%), Positives = 69/143 (48%), Gaps = 6/143 (4%)

Query: 78  LAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGG 137
           L  ++  +GG D  G  +L  A+ Y+PE   W  + ++    RS    C L N +Y +GG
Sbjct: 468 LNRLLYAVGGFD--GTNRLNSAECYYPERNEWRMITAM-NTIRSGAGVCVLHNCIYAAGG 524

Query: 138 HINS---HDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERY 194
           +      + V  +     TW  VA +   R    + V QG+++ +GG+DG   L SVE Y
Sbjct: 525 YDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECY 584

Query: 195 DPFSNTWAAAAPLPEAVSSAAVA 217
           DP ++TW+    +    S   VA
Sbjct: 585 DPDTDTWSEVTRMTSGRSGVGVA 607


>gi|40255071 kelch-like 23 [Homo sapiens]
          Length = 558

 Score =  121 bits (304), Expect = 9e-28
 Identities = 92/366 (25%), Positives = 155/366 (42%), Gaps = 24/366 (6%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           ++W  HD   R   L  LL ++ + +  P Y         L  A G  R  LL      I
Sbjct: 205 IKWTAHDVENRIECLYNLLSYINIDI-DPVY---------LKTALGLQRSCLLTENK--I 252

Query: 61  LGREAGALRTRPRRFMDLAEVIV-VIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYT 119
                 AL    +     +   + +IGG     L ++   D   P +  W     +P YT
Sbjct: 253 RSLIYNALNPMHKEISQRSTATMYIIGGYYWHPLSEVHIWD---PLTNVWIQGAEIPDYT 309

Query: 120 RSEFAACALRNDVYVSGGHINSH-----DVWMFSSHLHTWIKVASLHKGRWRHKMAVVQG 174
           R  +    L  ++YV+GG+   +      VW+++S    W +   +   R+ H    + G
Sbjct: 310 RESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGG 369

Query: 175 QLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGG--ARQG 232
            ++A+GG+         E YDP    W   A + + V +A        ++VIGG    +G
Sbjct: 370 CVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRG 429

Query: 233 GVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGLMSKIFTYDPGTDVWG 292
               DKVQ ++   + WSL + +P  +  L +V  E+ +Y++GG  +    YDP  + W 
Sbjct: 430 SCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQTTITECYDPEQNEWR 489

Query: 293 EAAVLPSPVESCGVTVCDGKVHILGGRD-DRGESTDKVFTFDPSSGQVEVQPSLQRCTSS 351
           E A +      CG  + +G +++ GG    +G     +  +DP   + E+  +L     S
Sbjct: 490 EIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRS 549

Query: 352 HGCVTI 357
           HGCV +
Sbjct: 550 HGCVCV 555


>gi|8922854 kelch-like 26 [Homo sapiens]
          Length = 615

 Score =  117 bits (292), Expect = 2e-26
 Identities = 88/346 (25%), Positives = 149/346 (43%), Gaps = 38/346 (10%)

Query: 1   MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
           +RW++HD PARR +   +L H+R PL+  +  ++ V+  +++     CR  LLEA    +
Sbjct: 231 VRWLQHD-PARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQV 289

Query: 61  LGREAGALRTRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTR 120
           L      +++           +V  GG         P+ D+    S +   LP  PG   
Sbjct: 290 LPFRQHEMQSPRTAVRSDVPSLVTFGGT--------PYTDSDRSVSSKVYQLPE-PGARH 340

Query: 121 -----------SEFAACALRNDVYVSGG-HINSHD-------VWMFSSHLHTWIKVASLH 161
                      S      L N VYV+GG H+            + +  HL+ W+++ ++ 
Sbjct: 341 FRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQ 400

Query: 162 KGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAG 221
           + R + ++ V+ G ++A GG +    L SVERY P  N W  A  L       A A+  G
Sbjct: 401 ESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGG 460

Query: 222 KLFVIGGARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGLMSKI 281
           +L++ GG      +   + C+DP  D+W  ++P    +     V     IY +GG M  +
Sbjct: 461 RLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHV 520

Query: 282 FT---------YDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGG 318
                      Y P TD W   + + +     G  + + K++I+GG
Sbjct: 521 DRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGG 566



 Score = 34.7 bits (78), Expect = 0.14
 Identities = 35/153 (22%), Positives = 54/153 (35%), Gaps = 9/153 (5%)

Query: 212 SSAAVASCAGKLFVIGGA----RQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSL 267
           S   VA     ++V GG     R G    D    +DP  +RW        S+   +   L
Sbjct: 352 SHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVL 411

Query: 268 EDTIYVMGGL-----MSKIFTYDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDR 322
              +Y  GG      ++ +  Y P  + WG A  L             G+++I GG    
Sbjct: 412 CGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGGRLYISGGYGIS 471

Query: 323 GESTDKVFTFDPSSGQVEVQPSLQRCTSSHGCV 355
            E    +  +DP + Q E +  +      H  V
Sbjct: 472 VEDKKALHCYDPVADQWEFKAPMSEPRVLHAMV 504



 Score = 28.5 bits (62), Expect = 9.8
 Identities = 12/37 (32%), Positives = 20/37 (54%), Gaps = 1/37 (2%)

Query: 102 YHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGGH 138
           Y PE+ +WT +  +    +SE   C L   +Y+ GG+
Sbjct: 532 YVPETDQWTSVSPMRA-GQSEAGCCLLERKIYIVGGY 567


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.138    0.441 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,334,927
Number of Sequences: 37866
Number of extensions: 719790
Number of successful extensions: 2371
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 1400
Number of HSP's gapped (non-prelim): 246
length of query: 363
length of database: 18,247,518
effective HSP length: 104
effective length of query: 259
effective length of database: 14,309,454
effective search space: 3706148586
effective search space used: 3706148586
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.