Guide to the Human Genome
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Search of human proteins with 7019333

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7019333 nuclear receptor binding protein [Homo sapiens]
         (535 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7019333 nuclear receptor binding protein [Homo sapiens]           1067   0.0  
gi|30794272 nuclear receptor binding protein 2 [Homo sapiens]         264   2e-70
gi|50845418 WNK lysine deficient protein kinase 3 isoform 1 [Hom...   153   4e-37
gi|50845416 WNK lysine deficient protein kinase 3 isoform 2 [Hom...   153   4e-37
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]      151   1e-36
gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]      145   1e-34
gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens]     144   2e-34
gi|191252782 p21-activated kinase 6 [Homo sapiens]                     71   2e-12
gi|191252780 p21-activated kinase 6 [Homo sapiens]                     71   2e-12
gi|9910476 p21-activated kinase 6 [Homo sapiens]                       71   2e-12
gi|19424132 NIMA-related kinase 7 [Homo sapiens]                       69   1e-11
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]            68   2e-11
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]           66   9e-11
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]           65   1e-10
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]           65   1e-10
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]           65   1e-10
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]           65   1e-10
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]           65   1e-10
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]             65   1e-10
gi|222136641 NIMA-related kinase 9 [Homo sapiens]                      65   1e-10
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]           65   2e-10
gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]           65   2e-10
gi|38327568 serine/threonine protein kinase 6 [Homo sapiens]           65   2e-10
gi|38327566 serine/threonine protein kinase 6 [Homo sapiens]           65   2e-10
gi|38327564 serine/threonine protein kinase 6 [Homo sapiens]           65   2e-10
gi|38327562 serine/threonine protein kinase 6 [Homo sapiens]           65   2e-10
gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens]            65   2e-10
gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens]            65   2e-10
gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens]            65   2e-10
gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens]            65   2e-10

>gi|7019333 nuclear receptor binding protein [Homo sapiens]
          Length = 535

 Score = 1067 bits (2759), Expect = 0.0
 Identities = 535/535 (100%), Positives = 535/535 (100%)

Query: 1   MSEGESQTVLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEESP 60
           MSEGESQTVLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEESP
Sbjct: 1   MSEGESQTVLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEESP 60

Query: 61  CGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDN 120
           CGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDN
Sbjct: 61  CGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDN 120

Query: 121 LIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRW 180
           LIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRW
Sbjct: 121 LIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRW 180

Query: 181 CTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNL 240
           CTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNL
Sbjct: 181 CTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNL 240

Query: 241 HFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQLLEDPLQ 300
           HFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQLLEDPLQ
Sbjct: 241 HFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQLLEDPLQ 300

Query: 301 REFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNM 360
           REFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNM
Sbjct: 301 REFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNM 360

Query: 361 DTSAVLAEIPAGPGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEV 420
           DTSAVLAEIPAGPGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEV
Sbjct: 361 DTSAVLAEIPAGPGREPVQTLYSQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEV 420

Query: 421 TSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHLTLLLKLEDKLNRHLSCDL 480
           TSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHLTLLLKLEDKLNRHLSCDL
Sbjct: 421 TSPVVPPSVKTPTPEPAEVETRKVVLMQCNIESVEEGVKHHLTLLLKLEDKLNRHLSCDL 480

Query: 481 MPNENIPELAAELVQLGFISEADQSRLTSLLEETLNKFNFARNSTLNSAAVTVSS 535
           MPNENIPELAAELVQLGFISEADQSRLTSLLEETLNKFNFARNSTLNSAAVTVSS
Sbjct: 481 MPNENIPELAAELVQLGFISEADQSRLTSLLEETLNKFNFARNSTLNSAAVTVSS 535


>gi|30794272 nuclear receptor binding protein 2 [Homo sapiens]
          Length = 258

 Score =  264 bits (674), Expect = 2e-70
 Identities = 146/261 (55%), Positives = 179/261 (68%), Gaps = 14/261 (5%)

Query: 264 MCALEMAVLEIQGNGESSYVPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLF 323
           MCALEMAVLEIQ NG++  V +EAI+ A   L DP  REFI  CL  +PARRP+A  LLF
Sbjct: 1   MCALEMAVLEIQTNGDTR-VTEEAIARARHSLSDPNMREFILCCLARDPARRPSAHSLLF 59

Query: 324 HPALFEVPSLKLLAAHCIVGHQHMIPENALEEITKNMDTSAVLAEIPAGPGREPVQTLYS 383
           H  LFEV SLKLLAAHC + HQ+++PEN +EE TK MD  AVLAE+P  P R P+Q  YS
Sbjct: 60  HRVLFEVHSLKLLAAHCFIQHQYLMPENVVEEKTKAMDLHAVLAELPR-PRRPPLQWRYS 118

Query: 384 QSPALELDKFLEDVRNGIYPLTAF------GLPRPQQPQQEEVTSPVVPPSVKTPTPEPA 437
           +   +ELDKFLEDVRNGIYPL  F      GLPR   P  EEV         KTPTPEP 
Sbjct: 119 EVSFMELDKFLEDVRNGIYPLMNFAATRPLGLPRVLAPPPEEV------QKAKTPTPEPF 172

Query: 438 EVETRKVVLMQCNIESVEEGVKHHLTLLLKLEDKLNRHLSCDLMPNENIPELAAELVQLG 497
           + ETRKV+ MQCN+E  E+  + HLTLLL LED+L+R L+ DL+P ++  +LA+ELV  G
Sbjct: 173 DSETRKVIQMQCNLERSEDKARWHLTLLLVLEDRLHRQLTYDLLPTDSAQDLASELVHYG 232

Query: 498 FISEADQSRLTSLLEETLNKF 518
           F+ E D+ +L + LE T  K+
Sbjct: 233 FLHEDDRMKLAAFLESTFLKY 253


>gi|50845418 WNK lysine deficient protein kinase 3 isoform 1 [Homo
           sapiens]
          Length = 1800

 Score =  153 bits (386), Expect = 4e-37
 Identities = 108/334 (32%), Positives = 164/334 (49%), Gaps = 24/334 (7%)

Query: 9   VLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEESPCGRWQKRR 68
           VL  G + K E  S +      +  ++        E+E E E E + +  SP GR+ K  
Sbjct: 97  VLRGGQEVKYEQCSKS------TSEISKDCFKEKNEKEMEEEAEMKAVATSPSGRFLKFD 150

Query: 69  EEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLN 128
            E+ +       + Y  +DTE  VEV W E+Q  +RK  K ++++ +   + L  L+H N
Sbjct: 151 IELGRG---AFKTVYKGLDTETWVEVAWCELQ--DRKLTKAEQQRFKEEAEMLKGLQHPN 205

Query: 129 IVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSAL 188
           IV+F+  W  I + K  ++ +TE M+SG+LK +LK+     K M  K  + WC QIL  L
Sbjct: 206 IVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR----FKVMKPKVLRSWCRQILKGL 261

Query: 189 SYLHSCDPPIIHGNLTCDTIFIQ-HNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEY 247
            +LH+  PPIIH +L CD IFI    G +KIG +   T+       +       F APE 
Sbjct: 262 QFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL-MRTSFAKSVIGTPEFMAPEM 320

Query: 248 GEVTNVTTAVDIYSFGMCALEMAVLEIQ----GNGESSY--VPQEAISSAIQLLEDPLQR 301
            E  +   +VD+Y+FGMC LEMA  E       N    Y  V      ++   + DP  +
Sbjct: 321 YE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVK 379

Query: 302 EFIQKCLQSEPARRPTARELLFHPALFEVPSLKL 335
           E I+ C++   + R + R+LL H    E   L++
Sbjct: 380 EIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRV 413


>gi|50845416 WNK lysine deficient protein kinase 3 isoform 2 [Homo
           sapiens]
          Length = 1743

 Score =  153 bits (386), Expect = 4e-37
 Identities = 108/334 (32%), Positives = 164/334 (49%), Gaps = 24/334 (7%)

Query: 9   VLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEESPCGRWQKRR 68
           VL  G + K E  S +      +  ++        E+E E E E + +  SP GR+ K  
Sbjct: 97  VLRGGQEVKYEQCSKS------TSEISKDCFKEKNEKEMEEEAEMKAVATSPSGRFLKFD 150

Query: 69  EEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLN 128
            E+ +       + Y  +DTE  VEV W E+Q  +RK  K ++++ +   + L  L+H N
Sbjct: 151 IELGRG---AFKTVYKGLDTETWVEVAWCELQ--DRKLTKAEQQRFKEEAEMLKGLQHPN 205

Query: 129 IVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSAL 188
           IV+F+  W  I + K  ++ +TE M+SG+LK +LK+     K M  K  + WC QIL  L
Sbjct: 206 IVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR----FKVMKPKVLRSWCRQILKGL 261

Query: 189 SYLHSCDPPIIHGNLTCDTIFIQ-HNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEY 247
            +LH+  PPIIH +L CD IFI    G +KIG +   T+       +       F APE 
Sbjct: 262 QFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL-MRTSFAKSVIGTPEFMAPEM 320

Query: 248 GEVTNVTTAVDIYSFGMCALEMAVLEIQ----GNGESSY--VPQEAISSAIQLLEDPLQR 301
            E  +   +VD+Y+FGMC LEMA  E       N    Y  V      ++   + DP  +
Sbjct: 321 YE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVK 379

Query: 302 EFIQKCLQSEPARRPTARELLFHPALFEVPSLKL 335
           E I+ C++   + R + R+LL H    E   L++
Sbjct: 380 EIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRV 413


>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
          Length = 2217

 Score =  151 bits (382), Expect = 1e-36
 Identities = 102/299 (34%), Positives = 152/299 (50%), Gaps = 18/299 (6%)

Query: 33  PVTSTTSAASPEEEEESEDESEILEESPCGRWQKRREEVNQRNVPGIDSAYLAMDTEEGV 92
           P    T    PEEEE+ ED+ + +  S  GR+ K   E+ + +     + Y  +DTE  V
Sbjct: 163 PEPGRTRRDEPEEEEDDEDDLKAVATSLDGRFLKFDIELGRGS---FKTVYKGLDTETWV 219

Query: 93  EVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEY 152
           EV W E+Q  +RK  KL+ ++ +   + L  L+H NIV+F+ +W    + K  ++ +TE 
Sbjct: 220 EVAWCELQ--DRKLTKLERQRFKEEAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTEL 277

Query: 153 MSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQ- 211
           M+SG+LK +LK+     K M  K  + WC QIL  L +LH+  PPIIH +L CD IFI  
Sbjct: 278 MTSGTLKTYLKR----FKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITG 333

Query: 212 HNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAV 271
             G +KIG +   T+       +       F APE  E  +   +VD+Y+FGMC LEMA 
Sbjct: 334 PTGSVKIGDLGLATL-KRASFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMAT 391

Query: 272 LEIQ----GNGESSY--VPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFH 324
            E       N    Y  V      ++ + + DP  +E I +C+      R   ++LL H
Sbjct: 392 SEYPYSECQNAAQIYRKVTCGIKPASFEKVHDPEIKEIIGECICKNKEERYEIKDLLSH 450


>gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]
          Length = 1243

 Score =  145 bits (365), Expect = 1e-34
 Identities = 129/488 (26%), Positives = 210/488 (43%), Gaps = 67/488 (13%)

Query: 2   SEGESQTVLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEESPC 61
           +EG         + P++  S+  PG         +       E+EE+ + E++ +  SP 
Sbjct: 111 TEGAPVKAAEDSARPELPDSAVGPGSREPLRVPEAVALERRREQEEKEDMETQAVATSPD 170

Query: 62  GRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNL 121
           GR+ K   E+ + +     + Y  +DT+  VEV W E+Q   RK  + + ++     + L
Sbjct: 171 GRYLKFDIEIGRGS---FKTVYRGLDTDTTVEVAWCELQ--TRKLSRAERQRFSEEVEML 225

Query: 122 IQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWC 181
             L+H NIV+F+  W  +   +  ++ +TE M+SG+LK +L++ ++    M  +  +RW 
Sbjct: 226 KGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFRE----MKPRVLQRWS 281

Query: 182 TQILSALSYLHSCDPPIIHGNLTCDTIFIQ-HNGLIKIGSVAPDTINNHVKTCREEQKNL 240
            QIL  L +LHS  PPI+H +L CD +FI    G +KIG +   T+       +      
Sbjct: 282 RQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATL-KRASFAKSVIGTP 340

Query: 241 HFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQ----GNGESSY--VPQEAISSAIQL 294
            F APE  E      AVD+Y+FGMC LEMA  E       N    Y  V      ++   
Sbjct: 341 EFMAPEMYE-EKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHK 399

Query: 295 LEDPLQREFIQKCLQSEPARRPTARELLFHPALF----------------EVPSLKLLAA 338
           ++ P  +E I+ C++++   R T ++LL H A F                E P LKL   
Sbjct: 400 VKIPEVKEIIEGCIRTDKNERFTIQDLLAH-AFFREERGVHVELAEEDDGEKPGLKLWLR 458

Query: 339 ------------HCIVGHQHMIPENALEEITKNMDTSAVLAEIPAGP----GREPVQTLY 382
                       +  +     +  +A EE+ + M    ++ E    P     RE V  + 
Sbjct: 459 MEDARRGGRPRDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQ 518

Query: 383 SQSPALELDKFLEDVRNGIYPLTAFGLPRPQQPQQEEVTSPVV--PPSVKTPTPEPAEVE 440
            +   L   + LE +              P +P     T P+   PPSV  P PE  E +
Sbjct: 519 RKREKLRKARELEAL--------------PPEPGPPPATVPMAPGPPSVFPPEPEEPEAD 564

Query: 441 TRKVVLMQ 448
             +  L +
Sbjct: 565 QHQPFLFR 572


>gi|148612809 WNK lysine deficient protein kinase 1 [Homo sapiens]
          Length = 2382

 Score =  144 bits (364), Expect = 2e-34
 Identities = 111/333 (33%), Positives = 162/333 (48%), Gaps = 27/333 (8%)

Query: 8   TVLSSGSDPKVESSSSAPGLTSVSPPVTSTT---SAASPEEEE-ESEDESEILEE----- 58
           TV SS S  +  S  S  G     PP  S +   SA  P+EE  + +D+ E LE      
Sbjct: 155 TVPSSTSKDRPVSQPSLVGSKEEPPPARSGSGGGSAKEPQEERSQQQDDIEELETKAVGM 214

Query: 59  SPCGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVF 118
           S  GR+ K   E+ + +     + Y  +DTE  VEV W E+Q  +RK  K + ++ +   
Sbjct: 215 SNDGRFLKFDIEIGRGS---FKTVYKGLDTETTVEVAWCELQ--DRKLTKSERQRFKEEA 269

Query: 119 DNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWK 178
           + L  L+H NIV+F+  W    + K  ++ +TE M+SG+LK +LK+     K M  K  +
Sbjct: 270 EMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKR----FKVMKIKVLR 325

Query: 179 RWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQ-HNGLIKIGSVAPDTINNHVKTCREEQ 237
            WC QIL  L +LH+  PPIIH +L CD IFI    G +KIG +   T+       +   
Sbjct: 326 SWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL-KRASFAKSVI 384

Query: 238 KNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQ----GNGESSY--VPQEAISSA 291
               F APE  E      +VD+Y+FGMC LEMA  E       N    Y  V      ++
Sbjct: 385 GTPEFMAPEMYE-EKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPAS 443

Query: 292 IQLLEDPLQREFIQKCLQSEPARRPTARELLFH 324
              +  P  +E I+ C++     R + ++LL H
Sbjct: 444 FDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNH 476


>gi|191252782 p21-activated kinase 6 [Homo sapiens]
          Length = 681

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 61/259 (23%), Positives = 118/259 (45%), Gaps = 34/259 (13%)

Query: 84  LAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENK 143
           LA +   G +V    +   +++  +L   +V  + D     +H N+V+ +K +   +E  
Sbjct: 423 LAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRD----YQHFNVVEMYKSYLVGEE-- 476

Query: 144 ARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNL 203
             +  + E++  G+L   + + +     +NE+     C  +L AL+YLH+    +IH ++
Sbjct: 477 --LWVLMEFLQGGALTDIVSQVR-----LNEEQIATVCEAVLQALAYLHA--QGVIHRDI 527

Query: 204 TCDTIFIQHNGLIKIGSVA-PDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSF 262
             D+I +  +G +K+        I+  V   +      ++ APE    +   T VDI+S 
Sbjct: 528 KSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSL 587

Query: 263 GMCALEMAVLEIQGNGESSYVPQEAISSAIQLLEDP------------LQREFIQKCLQS 310
           G+  +EM       +GE  Y     + +  +L + P            + R+F+++ L  
Sbjct: 588 GIMVIEMV------DGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVR 641

Query: 311 EPARRPTARELLFHPALFE 329
           +P  R TA+ELL HP L +
Sbjct: 642 DPQERATAQELLDHPFLLQ 660


>gi|191252780 p21-activated kinase 6 [Homo sapiens]
          Length = 681

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 61/259 (23%), Positives = 118/259 (45%), Gaps = 34/259 (13%)

Query: 84  LAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENK 143
           LA +   G +V    +   +++  +L   +V  + D     +H N+V+ +K +   +E  
Sbjct: 423 LAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRD----YQHFNVVEMYKSYLVGEE-- 476

Query: 144 ARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNL 203
             +  + E++  G+L   + + +     +NE+     C  +L AL+YLH+    +IH ++
Sbjct: 477 --LWVLMEFLQGGALTDIVSQVR-----LNEEQIATVCEAVLQALAYLHA--QGVIHRDI 527

Query: 204 TCDTIFIQHNGLIKIGSVA-PDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSF 262
             D+I +  +G +K+        I+  V   +      ++ APE    +   T VDI+S 
Sbjct: 528 KSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSL 587

Query: 263 GMCALEMAVLEIQGNGESSYVPQEAISSAIQLLEDP------------LQREFIQKCLQS 310
           G+  +EM       +GE  Y     + +  +L + P            + R+F+++ L  
Sbjct: 588 GIMVIEMV------DGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVR 641

Query: 311 EPARRPTARELLFHPALFE 329
           +P  R TA+ELL HP L +
Sbjct: 642 DPQERATAQELLDHPFLLQ 660


>gi|9910476 p21-activated kinase 6 [Homo sapiens]
          Length = 681

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 61/259 (23%), Positives = 118/259 (45%), Gaps = 34/259 (13%)

Query: 84  LAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENK 143
           LA +   G +V    +   +++  +L   +V  + D     +H N+V+ +K +   +E  
Sbjct: 423 LAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRD----YQHFNVVEMYKSYLVGEE-- 476

Query: 144 ARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNL 203
             +  + E++  G+L   + + +     +NE+     C  +L AL+YLH+    +IH ++
Sbjct: 477 --LWVLMEFLQGGALTDIVSQVR-----LNEEQIATVCEAVLQALAYLHA--QGVIHRDI 527

Query: 204 TCDTIFIQHNGLIKIGSVA-PDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSF 262
             D+I +  +G +K+        I+  V   +      ++ APE    +   T VDI+S 
Sbjct: 528 KSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSL 587

Query: 263 GMCALEMAVLEIQGNGESSYVPQEAISSAIQLLEDP------------LQREFIQKCLQS 310
           G+  +EM       +GE  Y     + +  +L + P            + R+F+++ L  
Sbjct: 588 GIMVIEMV------DGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVR 641

Query: 311 EPARRPTARELLFHPALFE 329
           +P  R TA+ELL HP L +
Sbjct: 642 DPQERATAQELLDHPFLLQ 660


>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
          Length = 302

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 56/244 (22%), Positives = 111/244 (45%), Gaps = 19/244 (7%)

Query: 83  YLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKEN 142
           Y A    +GV V   +VQ  +  + K + + ++ + D L QL H N++K+  Y + I++N
Sbjct: 49  YRAACLLDGVPVALKKVQIFDLMDAKARADCIKEI-DLLKQLNHPNVIKY--YASFIEDN 105

Query: 143 KARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGN 202
           +  ++   E   +G L + +K  KK  + + E+   ++  Q+ SAL ++HS    ++H +
Sbjct: 106 ELNIVL--ELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHS--RRVMHRD 161

Query: 203 LTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNL-HFFAPEYGEVTNVTTAVDIYS 261
           +    +FI   G++K+G +      +   T         ++ +PE           DI+S
Sbjct: 162 IKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWS 221

Query: 262 FGMCALEMAVLEIQGNGESSYVPQEAISSAIQLLEDP---------LQREFIQKCLQSEP 312
            G    EMA L+    G+   +   ++   I+  + P           R+ +  C+  +P
Sbjct: 222 LGCLLYEMAALQSPFYGDKMNL--YSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDP 279

Query: 313 ARRP 316
            +RP
Sbjct: 280 EKRP 283


>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
          Length = 545

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 78/329 (23%), Positives = 144/329 (43%), Gaps = 43/329 (13%)

Query: 18  VESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEES----PCGRWQKRREEVNQ 73
           V +S  +P   + +PP   T +    +++ +  DE EILE+       G  +K+     +
Sbjct: 217 VATSPISPTENNTTPPDALTRNTEKQKKKPKMSDE-EILEKLRSIVSVGDPKKKYTRFEK 275

Query: 74  RNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFH 133
                  + Y AMD   G EV   ++   ++   +L   ++  + +N    ++ NIV + 
Sbjct: 276 IGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMREN----KNPNIVNYL 331

Query: 134 KYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHS 193
             +    E    +  + EY++ GSL   + +T      M+E      C + L AL +LHS
Sbjct: 332 DSYLVGDE----LWVVMEYLAGGSLTDVVTET-----CMDEGQIAAVCRECLQALEFLHS 382

Query: 194 CDPPIIHGNLTCDTIFIQHNGLIKI---GSVAPDTINNHVKTCREEQKNLHFFAPEYGEV 250
               +IH ++  D I +  +G +K+   G  A  T     ++        ++ APE    
Sbjct: 383 NQ--VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTP--YWMAPEVVTR 438

Query: 251 TNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQL-------LEDP----- 298
                 VDI+S G+ A+EM        GE  Y+ +  + +   +       L++P     
Sbjct: 439 KAYGPKVDIWSLGIMAIEMI------EGEPPYLNENPLRALYLIATNGTPELQNPEKLSA 492

Query: 299 LQREFIQKCLQSEPARRPTARELLFHPAL 327
           + R+F+ +CL+ +  +R +A+ELL H  L
Sbjct: 493 IFRDFLNRCLEMDVEKRGSAKELLQHQFL 521


>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
          Length = 553

 Score = 65.9 bits (159), Expect = 9e-11
 Identities = 76/324 (23%), Positives = 142/324 (43%), Gaps = 43/324 (13%)

Query: 18  VESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEES----PCGRWQKRREEVNQ 73
           V +S  +P   + +PP   T +    +++ +  DE EILE+       G  +K+     +
Sbjct: 217 VATSPISPTENNTTPPDALTRNTEKQKKKPKMSDE-EILEKLRSIVSVGDPKKKYTRFEK 275

Query: 74  RNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFH 133
                  + Y AMD   G EV   ++   ++   +L   ++  + +N    ++ NIV + 
Sbjct: 276 IGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMREN----KNPNIVNYL 331

Query: 134 KYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHS 193
             +    E    +  + EY++ GSL   + +T      M+E      C + L AL +LHS
Sbjct: 332 DSYLVGDE----LWVVMEYLAGGSLTDVVTET-----CMDEGQIAAVCRECLQALEFLHS 382

Query: 194 CDPPIIHGNLTCDTIFIQHNGLIKI---GSVAPDTINNHVKTCREEQKNLHFFAPEYGEV 250
               +IH ++  D I +  +G +K+   G  A  T     ++        ++ APE    
Sbjct: 383 NQ--VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTP--YWMAPEVVTR 438

Query: 251 TNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQL-------LEDP----- 298
                 VDI+S G+ A+EM        GE  Y+ +  + +   +       L++P     
Sbjct: 439 KAYGPKVDIWSLGIMAIEMI------EGEPPYLNENPLRALYLIATNGTPELQNPEKLSA 492

Query: 299 LQREFIQKCLQSEPARRPTARELL 322
           + R+F+ +CL+ +  +R +A+ELL
Sbjct: 493 IFRDFLNRCLEMDVEKRGSAKELL 516


>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
          Length = 559

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 79/341 (23%), Positives = 147/341 (43%), Gaps = 43/341 (12%)

Query: 6   SQTVLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEES----PC 61
           +++V+ S + P V +    P     +   T   +     ++ +  DE EILE+       
Sbjct: 218 TRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDE-EILEKLRSIVSV 276

Query: 62  GRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNL 121
           G  +K+     +       + Y A+D   G EV   ++   ++   +L   ++  + +N 
Sbjct: 277 GDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMREN- 335

Query: 122 IQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWC 181
              ++ NIV +   +    E    +  + EY++ GSL   + +T      M+E      C
Sbjct: 336 ---KNPNIVNYLDSYLVGDE----LWVVMEYLAGGSLTDVVTET-----CMDEGQIAAVC 383

Query: 182 TQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKI---GSVAPDTINNHVKTCREEQK 238
            + L AL +LHS    +IH ++  D I +  +G +K+   G  A  T     ++      
Sbjct: 384 RECLQALDFLHSNQ--VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 441

Query: 239 NLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQL---- 294
             ++ APE          VDI+S G+ A+EM        GE  Y+ +  + +   +    
Sbjct: 442 --YWMAPEVVTRKAYGPKVDIWSLGIMAIEMV------EGEPPYLNENPLRALYLIATNG 493

Query: 295 ---LEDPLQ-----REFIQKCLQSEPARRPTARELLFHPAL 327
              L++P +     R+F+ +CL+ +  RR +A+ELL HP L
Sbjct: 494 TPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 534



 Score = 29.6 bits (65), Expect = 7.2
 Identities = 13/27 (48%), Positives = 16/27 (59%)

Query: 28  TSVSPPVTSTTSAASPEEEEESEDESE 54
           T+  PP+    S    EEEEE EDE+E
Sbjct: 175 TASEPPLAPPVSEEEDEEEEEEEDENE 201


>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
          Length = 565

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 79/341 (23%), Positives = 147/341 (43%), Gaps = 43/341 (12%)

Query: 6   SQTVLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEES----PC 61
           +++V+ S + P V +    P     +   T   +     ++ +  DE EILE+       
Sbjct: 224 TRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDE-EILEKLRSIVSV 282

Query: 62  GRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNL 121
           G  +K+     +       + Y A+D   G EV   ++   ++   +L   ++  + +N 
Sbjct: 283 GDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMREN- 341

Query: 122 IQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWC 181
              ++ NIV +   +    E    +  + EY++ GSL   + +T      M+E      C
Sbjct: 342 ---KNPNIVNYLDSYLVGDE----LWVVMEYLAGGSLTDVVTET-----CMDEGQIAAVC 389

Query: 182 TQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKI---GSVAPDTINNHVKTCREEQK 238
            + L AL +LHS    +IH ++  D I +  +G +K+   G  A  T     ++      
Sbjct: 390 RECLQALDFLHSNQ--VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 447

Query: 239 NLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQL---- 294
             ++ APE          VDI+S G+ A+EM        GE  Y+ +  + +   +    
Sbjct: 448 --YWMAPEVVTRKAYGPKVDIWSLGIMAIEMV------EGEPPYLNENPLRALYLIATNG 499

Query: 295 ---LEDPLQ-----REFIQKCLQSEPARRPTARELLFHPAL 327
              L++P +     R+F+ +CL+ +  RR +A+ELL HP L
Sbjct: 500 TPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 540



 Score = 29.6 bits (65), Expect = 7.2
 Identities = 13/27 (48%), Positives = 16/27 (59%)

Query: 28  TSVSPPVTSTTSAASPEEEEESEDESE 54
           T+  PP+    S    EEEEE EDE+E
Sbjct: 181 TASEPPLAPPVSEEEDEEEEEEEDENE 207


>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
          Length = 580

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 79/341 (23%), Positives = 147/341 (43%), Gaps = 43/341 (12%)

Query: 6   SQTVLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEES----PC 61
           +++V+ S + P V +    P     +   T   +     ++ +  DE EILE+       
Sbjct: 239 TRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDE-EILEKLRSIVSV 297

Query: 62  GRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNL 121
           G  +K+     +       + Y A+D   G EV   ++   ++   +L   ++  + +N 
Sbjct: 298 GDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMREN- 356

Query: 122 IQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWC 181
              ++ NIV +   +    E    +  + EY++ GSL   + +T      M+E      C
Sbjct: 357 ---KNPNIVNYLDSYLVGDE----LWVVMEYLAGGSLTDVVTET-----CMDEGQIAAVC 404

Query: 182 TQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKI---GSVAPDTINNHVKTCREEQK 238
            + L AL +LHS    +IH ++  D I +  +G +K+   G  A  T     ++      
Sbjct: 405 RECLQALDFLHSNQ--VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 462

Query: 239 NLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQL---- 294
             ++ APE          VDI+S G+ A+EM        GE  Y+ +  + +   +    
Sbjct: 463 --YWMAPEVVTRKAYGPKVDIWSLGIMAIEMV------EGEPPYLNENPLRALYLIATNG 514

Query: 295 ---LEDPLQ-----REFIQKCLQSEPARRPTARELLFHPAL 327
              L++P +     R+F+ +CL+ +  RR +A+ELL HP L
Sbjct: 515 TPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 555



 Score = 29.6 bits (65), Expect = 7.2
 Identities = 13/27 (48%), Positives = 16/27 (59%)

Query: 28  TSVSPPVTSTTSAASPEEEEESEDESE 54
           T+  PP+    S    EEEEE EDE+E
Sbjct: 196 TASEPPLAPPVSEEEDEEEEEEEDENE 222


>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
          Length = 544

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 79/341 (23%), Positives = 147/341 (43%), Gaps = 43/341 (12%)

Query: 6   SQTVLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEES----PC 61
           +++V+ S + P V +    P     +   T   +     ++ +  DE EILE+       
Sbjct: 203 TRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDE-EILEKLRSIVSV 261

Query: 62  GRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNL 121
           G  +K+     +       + Y A+D   G EV   ++   ++   +L   ++  + +N 
Sbjct: 262 GDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMREN- 320

Query: 122 IQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWC 181
              ++ NIV +   +    E    +  + EY++ GSL   + +T      M+E      C
Sbjct: 321 ---KNPNIVNYLDSYLVGDE----LWVVMEYLAGGSLTDVVTET-----CMDEGQIAAVC 368

Query: 182 TQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKI---GSVAPDTINNHVKTCREEQK 238
            + L AL +LHS    +IH ++  D I +  +G +K+   G  A  T     ++      
Sbjct: 369 RECLQALDFLHSNQ--VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 426

Query: 239 NLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQL---- 294
             ++ APE          VDI+S G+ A+EM        GE  Y+ +  + +   +    
Sbjct: 427 --YWMAPEVVTRKAYGPKVDIWSLGIMAIEMV------EGEPPYLNENPLRALYLIATNG 478

Query: 295 ---LEDPLQ-----REFIQKCLQSEPARRPTARELLFHPAL 327
              L++P +     R+F+ +CL+ +  RR +A+ELL HP L
Sbjct: 479 TPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 519



 Score = 29.6 bits (65), Expect = 7.2
 Identities = 13/27 (48%), Positives = 16/27 (59%)

Query: 28  TSVSPPVTSTTSAASPEEEEESEDESE 54
           T+  PP+    S    EEEEE EDE+E
Sbjct: 160 TASEPPLAPPVSEEEDEEEEEEEDENE 186


>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
          Length = 544

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 79/341 (23%), Positives = 147/341 (43%), Gaps = 43/341 (12%)

Query: 6   SQTVLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEES----PC 61
           +++V+ S + P V +    P     +   T   +     ++ +  DE EILE+       
Sbjct: 203 TRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDE-EILEKLRSIVSV 261

Query: 62  GRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNL 121
           G  +K+     +       + Y A+D   G EV   ++   ++   +L   ++  + +N 
Sbjct: 262 GDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMREN- 320

Query: 122 IQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWC 181
              ++ NIV +   +    E    +  + EY++ GSL   + +T      M+E      C
Sbjct: 321 ---KNPNIVNYLDSYLVGDE----LWVVMEYLAGGSLTDVVTET-----CMDEGQIAAVC 368

Query: 182 TQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKI---GSVAPDTINNHVKTCREEQK 238
            + L AL +LHS    +IH ++  D I +  +G +K+   G  A  T     ++      
Sbjct: 369 RECLQALDFLHSNQ--VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 426

Query: 239 NLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQL---- 294
             ++ APE          VDI+S G+ A+EM        GE  Y+ +  + +   +    
Sbjct: 427 --YWMAPEVVTRKAYGPKVDIWSLGIMAIEMV------EGEPPYLNENPLRALYLIATNG 478

Query: 295 ---LEDPLQ-----REFIQKCLQSEPARRPTARELLFHPAL 327
              L++P +     R+F+ +CL+ +  RR +A+ELL HP L
Sbjct: 479 TPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 519



 Score = 29.6 bits (65), Expect = 7.2
 Identities = 13/27 (48%), Positives = 16/27 (59%)

Query: 28  TSVSPPVTSTTSAASPEEEEESEDESE 54
           T+  PP+    S    EEEEE EDE+E
Sbjct: 160 TASEPPLAPPVSEEEDEEEEEEEDENE 186


>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
          Length = 544

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 79/341 (23%), Positives = 147/341 (43%), Gaps = 43/341 (12%)

Query: 6   SQTVLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESEDESEILEES----PC 61
           +++V+ S + P V +    P     +   T   +     ++ +  DE EILE+       
Sbjct: 203 TRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDE-EILEKLRSIVSV 261

Query: 62  GRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNL 121
           G  +K+     +       + Y A+D   G EV   ++   ++   +L   ++  + +N 
Sbjct: 262 GDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMREN- 320

Query: 122 IQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWC 181
              ++ NIV +   +    E    +  + EY++ GSL   + +T      M+E      C
Sbjct: 321 ---KNPNIVNYLDSYLVGDE----LWVVMEYLAGGSLTDVVTET-----CMDEGQIAAVC 368

Query: 182 TQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKI---GSVAPDTINNHVKTCREEQK 238
            + L AL +LHS    +IH ++  D I +  +G +K+   G  A  T     ++      
Sbjct: 369 RECLQALDFLHSNQ--VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 426

Query: 239 NLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQL---- 294
             ++ APE          VDI+S G+ A+EM        GE  Y+ +  + +   +    
Sbjct: 427 --YWMAPEVVTRKAYGPKVDIWSLGIMAIEMV------EGEPPYLNENPLRALYLIATNG 478

Query: 295 ---LEDPLQ-----REFIQKCLQSEPARRPTARELLFHPAL 327
              L++P +     R+F+ +CL+ +  RR +A+ELL HP L
Sbjct: 479 TPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 519



 Score = 29.6 bits (65), Expect = 7.2
 Identities = 13/27 (48%), Positives = 16/27 (59%)

Query: 28  TSVSPPVTSTTSAASPEEEEESEDESE 54
           T+  PP+    S    EEEEE EDE+E
Sbjct: 160 TASEPPLAPPVSEEEDEEEEEEEDENE 186


>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
          Length = 979

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 61/256 (23%), Positives = 111/256 (43%), Gaps = 23/256 (8%)

Query: 82  AYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFDNLI---QLEHLNIVKFHKYWAD 138
           A L   TE+   VVW EV  +     +L E++ R   + ++    L+H NI+ ++ ++ D
Sbjct: 66  ATLYRRTEDDSLVVWKEVDLT-----RLSEKERRDALNEIVILALLQHDNIIAYYNHFMD 120

Query: 139 IKENKARVIFITEYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPI 198
                  ++   EY + G+L  + K  ++  K   E+    +  QI+SA+S +H     I
Sbjct: 121 ----NTTLLIELEYCNGGNL--YDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAG--I 172

Query: 199 IHGNLTCDTIFIQHNGLIKIGSVA-PDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAV 257
           +H ++    IF+    LIK+G       +N+            ++ +PE  +        
Sbjct: 173 LHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKS 232

Query: 258 DIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQLLEDPLQR------EFIQKCLQSE 311
           DI++ G    E+  L+   +  +       I   I+ +E    +      + +  CL  +
Sbjct: 233 DIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQD 292

Query: 312 PARRPTARELLFHPAL 327
           P +RPTA ELL  P L
Sbjct: 293 PEQRPTADELLDRPLL 308


>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
          Length = 403

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 72/290 (24%), Positives = 125/290 (43%), Gaps = 23/290 (7%)

Query: 42  SPEEEEESEDESEILEESPCGRWQKRREEVNQRNVPG-IDSAYLAMDTEEGVEVVWNEVQ 100
           +PEEE  S+ ++E   ES   +W     E+ +    G   + YLA + +    ++  +V 
Sbjct: 109 NPEEELASKQKNE---ESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKF-ILALKVL 164

Query: 101 FSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQ 160
           F  +      E ++R   +    L H NI++ + Y+ D      RV  I EY   G++ +
Sbjct: 165 FKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDA----TRVYLILEYAPLGTVYR 220

Query: 161 FLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGS 220
            L+K  K     +E+    + T++ +ALSY HS    +IH ++  + + +   G +KI  
Sbjct: 221 ELQKLSK----FDEQRTATYITELANALSYCHS--KRVIHRDIKPENLLLGSAGELKIAD 274

Query: 221 VAPDTINNHVKTCREEQK--NLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNG 278
                   H  + R       L +  PE  E       VD++S G+   E  V +     
Sbjct: 275 FGWSV---HAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEA 331

Query: 279 ESSYVPQEAISSAIQLLEDPLQ---REFIQKCLQSEPARRPTARELLFHP 325
            +     + IS       D +    R+ I + L+  P++RP  RE+L HP
Sbjct: 332 NTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHP 381


>gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]
          Length = 403

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 72/290 (24%), Positives = 125/290 (43%), Gaps = 23/290 (7%)

Query: 42  SPEEEEESEDESEILEESPCGRWQKRREEVNQRNVPG-IDSAYLAMDTEEGVEVVWNEVQ 100
           +PEEE  S+ ++E   ES   +W     E+ +    G   + YLA + +    ++  +V 
Sbjct: 109 NPEEELASKQKNE---ESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKF-ILALKVL 164

Query: 101 FSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQ 160
           F  +      E ++R   +    L H NI++ + Y+ D      RV  I EY   G++ +
Sbjct: 165 FKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDA----TRVYLILEYAPLGTVYR 220

Query: 161 FLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGS 220
            L+K  K     +E+    + T++ +ALSY HS    +IH ++  + + +   G +KI  
Sbjct: 221 ELQKLSK----FDEQRTATYITELANALSYCHS--KRVIHRDIKPENLLLGSAGELKIAD 274

Query: 221 VAPDTINNHVKTCREEQK--NLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNG 278
                   H  + R       L +  PE  E       VD++S G+   E  V +     
Sbjct: 275 FGWSV---HAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEA 331

Query: 279 ESSYVPQEAISSAIQLLEDPLQ---REFIQKCLQSEPARRPTARELLFHP 325
            +     + IS       D +    R+ I + L+  P++RP  RE+L HP
Sbjct: 332 NTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHP 381


>gi|38327568 serine/threonine protein kinase 6 [Homo sapiens]
          Length = 403

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 72/290 (24%), Positives = 125/290 (43%), Gaps = 23/290 (7%)

Query: 42  SPEEEEESEDESEILEESPCGRWQKRREEVNQRNVPG-IDSAYLAMDTEEGVEVVWNEVQ 100
           +PEEE  S+ ++E   ES   +W     E+ +    G   + YLA + +    ++  +V 
Sbjct: 109 NPEEELASKQKNE---ESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKF-ILALKVL 164

Query: 101 FSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQ 160
           F  +      E ++R   +    L H NI++ + Y+ D      RV  I EY   G++ +
Sbjct: 165 FKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDA----TRVYLILEYAPLGTVYR 220

Query: 161 FLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGS 220
            L+K  K     +E+    + T++ +ALSY HS    +IH ++  + + +   G +KI  
Sbjct: 221 ELQKLSK----FDEQRTATYITELANALSYCHS--KRVIHRDIKPENLLLGSAGELKIAD 274

Query: 221 VAPDTINNHVKTCREEQK--NLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNG 278
                   H  + R       L +  PE  E       VD++S G+   E  V +     
Sbjct: 275 FGWSV---HAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEA 331

Query: 279 ESSYVPQEAISSAIQLLEDPLQ---REFIQKCLQSEPARRPTARELLFHP 325
            +     + IS       D +    R+ I + L+  P++RP  RE+L HP
Sbjct: 332 NTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHP 381


>gi|38327566 serine/threonine protein kinase 6 [Homo sapiens]
          Length = 403

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 72/290 (24%), Positives = 125/290 (43%), Gaps = 23/290 (7%)

Query: 42  SPEEEEESEDESEILEESPCGRWQKRREEVNQRNVPG-IDSAYLAMDTEEGVEVVWNEVQ 100
           +PEEE  S+ ++E   ES   +W     E+ +    G   + YLA + +    ++  +V 
Sbjct: 109 NPEEELASKQKNE---ESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKF-ILALKVL 164

Query: 101 FSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQ 160
           F  +      E ++R   +    L H NI++ + Y+ D      RV  I EY   G++ +
Sbjct: 165 FKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDA----TRVYLILEYAPLGTVYR 220

Query: 161 FLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGS 220
            L+K  K     +E+    + T++ +ALSY HS    +IH ++  + + +   G +KI  
Sbjct: 221 ELQKLSK----FDEQRTATYITELANALSYCHS--KRVIHRDIKPENLLLGSAGELKIAD 274

Query: 221 VAPDTINNHVKTCREEQK--NLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNG 278
                   H  + R       L +  PE  E       VD++S G+   E  V +     
Sbjct: 275 FGWSV---HAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEA 331

Query: 279 ESSYVPQEAISSAIQLLEDPLQ---REFIQKCLQSEPARRPTARELLFHP 325
            +     + IS       D +    R+ I + L+  P++RP  RE+L HP
Sbjct: 332 NTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHP 381


>gi|38327564 serine/threonine protein kinase 6 [Homo sapiens]
          Length = 403

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 72/290 (24%), Positives = 125/290 (43%), Gaps = 23/290 (7%)

Query: 42  SPEEEEESEDESEILEESPCGRWQKRREEVNQRNVPG-IDSAYLAMDTEEGVEVVWNEVQ 100
           +PEEE  S+ ++E   ES   +W     E+ +    G   + YLA + +    ++  +V 
Sbjct: 109 NPEEELASKQKNE---ESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKF-ILALKVL 164

Query: 101 FSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQ 160
           F  +      E ++R   +    L H NI++ + Y+ D      RV  I EY   G++ +
Sbjct: 165 FKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDA----TRVYLILEYAPLGTVYR 220

Query: 161 FLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGS 220
            L+K  K     +E+    + T++ +ALSY HS    +IH ++  + + +   G +KI  
Sbjct: 221 ELQKLSK----FDEQRTATYITELANALSYCHS--KRVIHRDIKPENLLLGSAGELKIAD 274

Query: 221 VAPDTINNHVKTCREEQK--NLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNG 278
                   H  + R       L +  PE  E       VD++S G+   E  V +     
Sbjct: 275 FGWSV---HAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEA 331

Query: 279 ESSYVPQEAISSAIQLLEDPLQ---REFIQKCLQSEPARRPTARELLFHP 325
            +     + IS       D +    R+ I + L+  P++RP  RE+L HP
Sbjct: 332 NTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHP 381


>gi|38327562 serine/threonine protein kinase 6 [Homo sapiens]
          Length = 403

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 72/290 (24%), Positives = 125/290 (43%), Gaps = 23/290 (7%)

Query: 42  SPEEEEESEDESEILEESPCGRWQKRREEVNQRNVPG-IDSAYLAMDTEEGVEVVWNEVQ 100
           +PEEE  S+ ++E   ES   +W     E+ +    G   + YLA + +    ++  +V 
Sbjct: 109 NPEEELASKQKNE---ESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKF-ILALKVL 164

Query: 101 FSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQ 160
           F  +      E ++R   +    L H NI++ + Y+ D      RV  I EY   G++ +
Sbjct: 165 FKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDA----TRVYLILEYAPLGTVYR 220

Query: 161 FLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGS 220
            L+K  K     +E+    + T++ +ALSY HS    +IH ++  + + +   G +KI  
Sbjct: 221 ELQKLSK----FDEQRTATYITELANALSYCHS--KRVIHRDIKPENLLLGSAGELKIAD 274

Query: 221 VAPDTINNHVKTCREEQK--NLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNG 278
                   H  + R       L +  PE  E       VD++S G+   E  V +     
Sbjct: 275 FGWSV---HAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEA 331

Query: 279 ESSYVPQEAISSAIQLLEDPLQ---REFIQKCLQSEPARRPTARELLFHP 325
            +     + IS       D +    R+ I + L+  P++RP  RE+L HP
Sbjct: 332 NTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHP 381


>gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens]
          Length = 591

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 59/241 (24%), Positives = 108/241 (44%), Gaps = 36/241 (14%)

Query: 105 KNYKLQEEKVRAVFDNLIQL----EHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQ 160
           K   L++++ R +  N + +    +H N+V+ +  +    E    +  + E++  G+L  
Sbjct: 350 KKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDE----LWVVMEFLEGGALTD 405

Query: 161 FLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGS 220
            +      H  MNE+     C  +L ALS LH+    +IH ++  D+I + H+G +K+  
Sbjct: 406 IV-----THTRMNEEQIAAVCLAVLQALSVLHA--QGVIHRDIKSDSILLTHDGRVKLSD 458

Query: 221 VA-PDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGE 279
                 ++  V   +      ++ APE          VDI+S G+  +EM       +GE
Sbjct: 459 FGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMV------DGE 512

Query: 280 SSYVPQEAISSAIQLLED-------------PLQREFIQKCLQSEPARRPTARELLFHPA 326
             Y  +  +  A++++ D             P  + F+ + L  +PA+R TA ELL HP 
Sbjct: 513 PPYFNEPPLK-AMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPF 571

Query: 327 L 327
           L
Sbjct: 572 L 572


>gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens]
          Length = 438

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 59/241 (24%), Positives = 108/241 (44%), Gaps = 36/241 (14%)

Query: 105 KNYKLQEEKVRAVFDNLIQL----EHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQ 160
           K   L++++ R +  N + +    +H N+V+ +  +    E    +  + E++  G+L  
Sbjct: 197 KKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDE----LWVVMEFLEGGALTD 252

Query: 161 FLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGS 220
            +      H  MNE+     C  +L ALS LH+    +IH ++  D+I + H+G +K+  
Sbjct: 253 IV-----THTRMNEEQIAAVCLAVLQALSVLHA--QGVIHRDIKSDSILLTHDGRVKLSD 305

Query: 221 VA-PDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGE 279
                 ++  V   +      ++ APE          VDI+S G+  +EM       +GE
Sbjct: 306 FGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMV------DGE 359

Query: 280 SSYVPQEAISSAIQLLED-------------PLQREFIQKCLQSEPARRPTARELLFHPA 326
             Y  +  +  A++++ D             P  + F+ + L  +PA+R TA ELL HP 
Sbjct: 360 PPYFNEPPLK-AMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPF 418

Query: 327 L 327
           L
Sbjct: 419 L 419


>gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens]
          Length = 438

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 59/241 (24%), Positives = 108/241 (44%), Gaps = 36/241 (14%)

Query: 105 KNYKLQEEKVRAVFDNLIQL----EHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQ 160
           K   L++++ R +  N + +    +H N+V+ +  +    E    +  + E++  G+L  
Sbjct: 197 KKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDE----LWVVMEFLEGGALTD 252

Query: 161 FLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGS 220
            +      H  MNE+     C  +L ALS LH+    +IH ++  D+I + H+G +K+  
Sbjct: 253 IV-----THTRMNEEQIAAVCLAVLQALSVLHA--QGVIHRDIKSDSILLTHDGRVKLSD 305

Query: 221 VA-PDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGE 279
                 ++  V   +      ++ APE          VDI+S G+  +EM       +GE
Sbjct: 306 FGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMV------DGE 359

Query: 280 SSYVPQEAISSAIQLLED-------------PLQREFIQKCLQSEPARRPTARELLFHPA 326
             Y  +  +  A++++ D             P  + F+ + L  +PA+R TA ELL HP 
Sbjct: 360 PPYFNEPPLK-AMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPF 418

Query: 327 L 327
           L
Sbjct: 419 L 419


>gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens]
          Length = 591

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 59/241 (24%), Positives = 108/241 (44%), Gaps = 36/241 (14%)

Query: 105 KNYKLQEEKVRAVFDNLIQL----EHLNIVKFHKYWADIKENKARVIFITEYMSSGSLKQ 160
           K   L++++ R +  N + +    +H N+V+ +  +    E    +  + E++  G+L  
Sbjct: 350 KKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDE----LWVVMEFLEGGALTD 405

Query: 161 FLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGS 220
            +      H  MNE+     C  +L ALS LH+    +IH ++  D+I + H+G +K+  
Sbjct: 406 IV-----THTRMNEEQIAAVCLAVLQALSVLHA--QGVIHRDIKSDSILLTHDGRVKLSD 458

Query: 221 VA-PDTINNHVKTCREEQKNLHFFAPEYGEVTNVTTAVDIYSFGMCALEMAVLEIQGNGE 279
                 ++  V   +      ++ APE          VDI+S G+  +EM       +GE
Sbjct: 459 FGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMV------DGE 512

Query: 280 SSYVPQEAISSAIQLLED-------------PLQREFIQKCLQSEPARRPTARELLFHPA 326
             Y  +  +  A++++ D             P  + F+ + L  +PA+R TA ELL HP 
Sbjct: 513 PPYFNEPPLK-AMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPF 571

Query: 327 L 327
           L
Sbjct: 572 L 572


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.129    0.369 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,506,892
Number of Sequences: 37866
Number of extensions: 1064382
Number of successful extensions: 8254
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 100
Number of HSP's successfully gapped in prelim test: 410
Number of HSP's that attempted gapping in prelim test: 7311
Number of HSP's gapped (non-prelim): 935
length of query: 535
length of database: 18,247,518
effective HSP length: 107
effective length of query: 428
effective length of database: 14,195,856
effective search space: 6075826368
effective search space used: 6075826368
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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